ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.60604860
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.89608738
3	ATP synthesis coupled proton transport (GO:0015986)	4.89608738
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.43949532
5	valine metabolic process (GO:0006573)	4.36328673
6	cytidine metabolic process (GO:0046087)	4.12886210
7	cytidine catabolic process (GO:0006216)	4.12886210
8	cytidine deamination (GO:0009972)	4.12886210
9	chaperone-mediated protein transport (GO:0072321)	4.05526094
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00737789
11	protein neddylation (GO:0045116)	3.86403628
12	signal peptide processing (GO:0006465)	3.79665523
13	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.72268293
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.65179704
15	rRNA modification (GO:0000154)	3.62678900
16	branched-chain amino acid catabolic process (GO:0009083)	3.57052318
17	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.56041022
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.53153652
19	protein-cofactor linkage (GO:0018065)	3.51414570
20	prenylation (GO:0097354)	3.49802103
21	protein prenylation (GO:0018342)	3.49802103
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.46986696
23	pseudouridine synthesis (GO:0001522)	3.46677577
24	electron transport chain (GO:0022900)	3.45076415
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.43762502
26	respiratory electron transport chain (GO:0022904)	3.40585222
27	maturation of SSU-rRNA (GO:0030490)	3.35334347
28	proteasome assembly (GO:0043248)	3.34849347
29	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.31660064
30	L-fucose catabolic process (GO:0042355)	3.30254143
31	fucose catabolic process (GO:0019317)	3.30254143
32	L-fucose metabolic process (GO:0042354)	3.30254143
33	ribosomal large subunit biogenesis (GO:0042273)	3.24117169
34	regulation of regulatory T cell differentiation (GO:0045589)	3.23695815
35	GTP biosynthetic process (GO:0006183)	3.22712536
36	synapsis (GO:0007129)	3.19055038
37	respiratory chain complex IV assembly (GO:0008535)	3.18288251
38	rRNA methylation (GO:0031167)	3.16044120
39	branched-chain amino acid metabolic process (GO:0009081)	3.11658824
40	negative regulation of execution phase of apoptosis (GO:1900118)	3.06801422
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.06330851
42	ribosomal small subunit assembly (GO:0000028)	3.05547896
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05212287
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.04749812
45	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.03389711
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.02539888
47	termination of RNA polymerase III transcription (GO:0006386)	3.02539888
48	cytochrome complex assembly (GO:0017004)	3.01916146
49	activated T cell proliferation (GO:0050798)	3.01524349
50	ATP biosynthetic process (GO:0006754)	3.01157687
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97829740
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97829740
53	protein complex biogenesis (GO:0070271)	2.92163320
54	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91916859
55	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91916859
56	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91916859
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.91287704
58	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.90766880
59	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.90766880
60	isotype switching (GO:0045190)	2.90766880
61	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.89847390
62	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.89847390
63	piRNA metabolic process (GO:0034587)	2.87034886
64	tRNA processing (GO:0008033)	2.86054811
65	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.85360072
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.83073151
67	behavioral response to nicotine (GO:0035095)	2.82681091
68	DNA demethylation (GO:0080111)	2.78839261
69	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.78231233
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.77803041
71	indolalkylamine metabolic process (GO:0006586)	2.76252291
72	inner mitochondrial membrane organization (GO:0007007)	2.75912355
73	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.71649174
74	translation (GO:0006412)	2.71481241
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71317759
76	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71317759
77	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.67643211
78	adaptation of signaling pathway (GO:0023058)	2.67582476
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.67380523
80	ribosomal small subunit biogenesis (GO:0042274)	2.66565286
81	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.65113216
82	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64524884
83	amino acid salvage (GO:0043102)	2.63960502
84	L-methionine salvage (GO:0071267)	2.63960502
85	L-methionine biosynthetic process (GO:0071265)	2.63960502
86	cotranslational protein targeting to membrane (GO:0006613)	2.62377438
87	proton transport (GO:0015992)	2.60974719
88	rRNA processing (GO:0006364)	2.59764534
89	auditory receptor cell stereocilium organization (GO:0060088)	2.59302575
90	rRNA metabolic process (GO:0016072)	2.58976490
91	UTP biosynthetic process (GO:0006228)	2.58964814
92	protein targeting to ER (GO:0045047)	2.57158599
93	maturation of 5.8S rRNA (GO:0000460)	2.56913115
94	hydrogen ion transmembrane transport (GO:1902600)	2.56222828
95	resolution of meiotic recombination intermediates (GO:0000712)	2.56206886
96	viral transcription (GO:0019083)	2.55795824
97	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.54025985
98	hydrogen transport (GO:0006818)	2.53800179
99	negative regulation of ligase activity (GO:0051352)	2.51235835
100	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.51235835

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.92968752
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.77062209
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.60227983
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.36714784
5	VDR_22108803_ChIP-Seq_LS180_Human	3.24443541
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.19916421
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.02444251
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98682279
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92015561
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70428718
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.68141521
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.66826628
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30782349
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.29574567
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28189856
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.26977736
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.22826723
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17744446
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.15933840
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96248742
21	EWS_26573619_Chip-Seq_HEK293_Human	1.89319706
22	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.74430205
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73637431
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71624956
25	FUS_26573619_Chip-Seq_HEK293_Human	1.68472700
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.65707927
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.62841768
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60413707
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59973323
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.59004267
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58010027
32	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.57690701
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55010866
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50808947
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.49212997
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44300346
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43720371
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43432135
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.42482716
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.42286010
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.41926785
42	P300_19829295_ChIP-Seq_ESCs_Human	1.41475117
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.41253426
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38977466
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.38745601
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37853520
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35578638
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33393311
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33393311
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31470114
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26060988
52	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24839392
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22762551
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21119068
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21119068
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17376894
57	GATA3_26560356_Chip-Seq_TH2_Human	1.17210651
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16862926
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16299133
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15626924
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15257353
62	AR_20517297_ChIP-Seq_VCAP_Human	1.15030098
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14042633
64	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.11961580
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10670129
66	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07894198
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06983366
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04747900
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03316263
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02723781
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02655360
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.02655360
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01444372
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99559064
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99083535
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98642199
77	NCOR_22424771_ChIP-Seq_293T_Human	0.97551836
78	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96387912
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96358787
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.95664131
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95467003
82	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95303429
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95147294
84	EZH2_22144423_ChIP-Seq_EOC_Human	0.94863853
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94758192
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94334240
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93982935
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93918852
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93857998
90	P300_18555785_Chip-Seq_ESCs_Mouse	0.93267669
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93007886
92	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92909422
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.88850508
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88417826
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.88108254
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87479411
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87430516
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.87393049
99	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.87289632
100	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.87240836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.61661029
2	MP0009379_abnormal_foot_pigmentation	3.31505097
3	MP0008877_abnormal_DNA_methylation	3.14785625
4	MP0001873_stomach_inflammation	2.93339445
5	MP0003011_delayed_dark_adaptation	2.76468313
6	MP0001835_abnormal_antigen_presentation	2.50287923
7	MP0002254_reproductive_system_inflammat	2.32800426
8	MP0008058_abnormal_DNA_repair	2.31417225
9	MP0002876_abnormal_thyroid_physiology	2.30533345
10	MP0005645_abnormal_hypothalamus_physiol	2.28216565
11	MP0005670_abnormal_white_adipose	2.26097022
12	MP0006072_abnormal_retinal_apoptosis	2.25586068
13	MP0002163_abnormal_gland_morphology	2.18143646
14	MP0003646_muscle_fatigue	1.94037056
15	MP0008875_abnormal_xenobiotic_pharmacok	1.91364661
16	MP0003195_calcinosis	1.87476993
17	MP0003183_abnormal_peptide_metabolism	1.86028313
18	MP0008872_abnormal_physiological_respon	1.84114698
19	MP0009333_abnormal_splenocyte_physiolog	1.83038814
20	MP0002837_dystrophic_cardiac_calcinosis	1.79791085
21	MP0006292_abnormal_olfactory_placode	1.77786607
22	MP0005387_immune_system_phenotype	1.74844560
23	MP0001790_abnormal_immune_system	1.74844560
24	MP0002102_abnormal_ear_morphology	1.74162911
25	MP0002638_abnormal_pupillary_reflex	1.73288823
26	MP0009785_altered_susceptibility_to	1.71563715
27	MP0005360_urolithiasis	1.67499102
28	MP0000685_abnormal_immune_system	1.63351095
29	MP0001919_abnormal_reproductive_system	1.60182588
30	MP0001800_abnormal_humoral_immune	1.58673813
31	MP0005389_reproductive_system_phenotype	1.58434898
32	MP0003693_abnormal_embryo_hatching	1.58154062
33	MP0004145_abnormal_muscle_electrophysio	1.57873345
34	MP0005551_abnormal_eye_electrophysiolog	1.55702740
35	MP0002148_abnormal_hypersensitivity_rea	1.50203258
36	MP0000372_irregular_coat_pigmentation	1.49655863
37	MP0005084_abnormal_gallbladder_morpholo	1.43429706
38	MP0005379_endocrine/exocrine_gland_phen	1.39268552
39	MP0002166_altered_tumor_susceptibility	1.35730382
40	MP0004142_abnormal_muscle_tone	1.30116738
41	MP0003718_maternal_effect	1.29190794
42	MP0001905_abnormal_dopamine_level	1.27230688
43	MP0003806_abnormal_nucleotide_metabolis	1.26793915
44	MP0002138_abnormal_hepatobiliary_system	1.26383896
45	MP0001984_abnormal_olfaction	1.25606168
46	MP0001986_abnormal_taste_sensitivity	1.25508241
47	MP0002277_abnormal_respiratory_mucosa	1.22887221
48	MP0001663_abnormal_digestive_system	1.19721537
49	MP0006036_abnormal_mitochondrial_physio	1.19087375
50	MP0002736_abnormal_nociception_after	1.17484559
51	MP0005253_abnormal_eye_physiology	1.16511977
52	MP0003787_abnormal_imprinting	1.15990828
53	MP0001968_abnormal_touch/_nociception	1.15184520
54	MP0001188_hyperpigmentation	1.13269732
55	MP0005410_abnormal_fertilization	1.11647278
56	MP0003786_premature_aging	1.11141568
57	MP0003045_fibrosis	1.08567774
58	MP0005636_abnormal_mineral_homeostasis	1.07824713
59	MP0002723_abnormal_immune_serum	1.04810846
60	MP0001485_abnormal_pinna_reflex	1.03382270
61	MP0010094_abnormal_chromosome_stability	1.02771383
62	MP0010155_abnormal_intestine_physiology	1.02318278
63	MP0002160_abnormal_reproductive_system	1.01775493
64	MP0002210_abnormal_sex_determination	1.01374317
65	MP0002938_white_spotting	1.00574880
66	MP0002452_abnormal_antigen_presenting	0.99304944
67	MP0002420_abnormal_adaptive_immunity	0.99067256
68	MP0005332_abnormal_amino_acid	0.98041238
69	MP0003763_abnormal_thymus_physiology	0.97539230
70	MP0001819_abnormal_immune_cell	0.94187704
71	MP0005000_abnormal_immune_tolerance	0.94151377
72	MP0002006_tumorigenesis	0.91387180
73	MP0002693_abnormal_pancreas_physiology	0.90339138
74	MP0003866_abnormal_defecation	0.90104333
75	MP0001929_abnormal_gametogenesis	0.89229932
76	MP0009745_abnormal_behavioral_response	0.88143956
77	MP0008995_early_reproductive_senescence	0.87896833
78	MP0001853_heart_inflammation	0.87256576
79	MP0001845_abnormal_inflammatory_respons	0.86708901
80	MP0005085_abnormal_gallbladder_physiolo	0.83078593
81	MP0000653_abnormal_sex_gland	0.82144412
82	MP0009764_decreased_sensitivity_to	0.81990191
83	MP0006276_abnormal_autonomic_nervous	0.81640648
84	MP0006082_CNS_inflammation	0.79798701
85	MP0001145_abnormal_male_reproductive	0.78659668
86	MP0003936_abnormal_reproductive_system	0.77822001
87	MP0002405_respiratory_system_inflammati	0.77736593
88	MP0001764_abnormal_homeostasis	0.76733254
89	MP0001881_abnormal_mammary_gland	0.76647357
90	MP0000613_abnormal_salivary_gland	0.76323554
91	MP0003941_abnormal_skin_development	0.74387849
92	MP0003186_abnormal_redox_activity	0.72981615
93	MP0001529_abnormal_vocalization	0.72831147
94	MP0002272_abnormal_nervous_system	0.72298562
95	MP0005174_abnormal_tail_pigmentation	0.71191796
96	MP0002095_abnormal_skin_pigmentation	0.70445156
97	MP0005075_abnormal_melanosome_morpholog	0.70444674
98	MP0001502_abnormal_circadian_rhythm	0.70346367
99	MP0000689_abnormal_spleen_morphology	0.69533321
100	MP0002398_abnormal_bone_marrow	0.68865138

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.93384824
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.62431623
3	3-Methylglutaconic aciduria (HP:0003535)	3.84506070
4	Acute necrotizing encephalopathy (HP:0006965)	3.74628734
5	Progressive macrocephaly (HP:0004481)	3.48599298
6	Hypoproteinemia (HP:0003075)	3.45854337
7	Stomatitis (HP:0010280)	3.42678320
8	Mitochondrial inheritance (HP:0001427)	3.30849794
9	Acute encephalopathy (HP:0006846)	3.25916580
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23329796
11	Increased CSF lactate (HP:0002490)	3.11202390
12	Renal cortical cysts (HP:0000803)	3.05438660
13	Congenital stationary night blindness (HP:0007642)	2.96903584
14	IgG deficiency (HP:0004315)	2.96104200
15	Dyschromatopsia (HP:0007641)	2.84248320
16	Attenuation of retinal blood vessels (HP:0007843)	2.83695445
17	Pancreatic cysts (HP:0001737)	2.81446147
18	Aplastic anemia (HP:0001915)	2.79562563
19	Lipid accumulation in hepatocytes (HP:0006561)	2.76811515
20	True hermaphroditism (HP:0010459)	2.73315668
21	Increased hepatocellular lipid droplets (HP:0006565)	2.72137085
22	Abnormality of the renal cortex (HP:0011035)	2.71825431
23	Decreased central vision (HP:0007663)	2.71148814
24	Optic disc pallor (HP:0000543)	2.64040418
25	Pendular nystagmus (HP:0012043)	2.62685012
26	Pancreatic fibrosis (HP:0100732)	2.54507519
27	Molar tooth sign on MRI (HP:0002419)	2.51516350
28	Abnormality of midbrain morphology (HP:0002418)	2.51516350
29	Abolished electroretinogram (ERG) (HP:0000550)	2.49931248
30	Methylmalonic acidemia (HP:0002912)	2.47675497
31	Colon cancer (HP:0003003)	2.47169573
32	Hepatocellular necrosis (HP:0001404)	2.41020665
33	Methylmalonic aciduria (HP:0012120)	2.38772876
34	Cerebral edema (HP:0002181)	2.36208297
35	Lethargy (HP:0001254)	2.33621404
36	Autoimmune hemolytic anemia (HP:0001890)	2.33160026
37	Hepatic necrosis (HP:0002605)	2.32591987
38	Constricted visual fields (HP:0001133)	2.32563003
39	Type II lissencephaly (HP:0007260)	2.27917315
40	Increased serum lactate (HP:0002151)	2.26702326
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24342036
42	Asplenia (HP:0001746)	2.24136971
43	Nephronophthisis (HP:0000090)	2.21341477
44	Absent/shortened dynein arms (HP:0200106)	2.18746018
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18746018
46	Lactic acidosis (HP:0003128)	2.14182441
47	Carpal bone hypoplasia (HP:0001498)	2.12447742
48	Exertional dyspnea (HP:0002875)	2.12118469
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07579955
50	Abnormality of B cell number (HP:0010975)	2.05477167
51	Abnormality of the prostate (HP:0008775)	2.01718676
52	Recurrent cutaneous fungal infections (HP:0011370)	2.01568469
53	Chronic mucocutaneous candidiasis (HP:0002728)	2.01568469
54	Hyperglycinemia (HP:0002154)	1.99558598
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98913765
56	Abnormality of alanine metabolism (HP:0010916)	1.98913765
57	Hyperalaninemia (HP:0003348)	1.98913765
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97217017
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97217017
60	Elevated erythrocyte sedimentation rate (HP:0003565)	1.96935259
61	Abnormal albumin level (HP:0012116)	1.95948616
62	Hypoalbuminemia (HP:0003073)	1.95948616
63	Pancytopenia (HP:0001876)	1.95504781
64	Respiratory failure (HP:0002878)	1.92883723
65	Hyperventilation (HP:0002883)	1.91902861
66	Alveolar cell carcinoma (HP:0006519)	1.91693481
67	Abnormality of T cells (HP:0002843)	1.90093270
68	Renal Fanconi syndrome (HP:0001994)	1.89047709
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.87459399
70	Abnormality of the renal medulla (HP:0100957)	1.86759110
71	Glycosuria (HP:0003076)	1.84642686
72	Abnormality of urine glucose concentration (HP:0011016)	1.84642686
73	B lymphocytopenia (HP:0010976)	1.83871753
74	Tubular atrophy (HP:0000092)	1.83204315
75	Respiratory difficulties (HP:0002880)	1.78133892
76	Clubbing of toes (HP:0100760)	1.78084150
77	Increased corneal curvature (HP:0100692)	1.77448301
78	Keratoconus (HP:0000563)	1.77448301
79	Abnormality of vitamin B metabolism (HP:0004340)	1.76978936
80	Congenital, generalized hypertrichosis (HP:0004540)	1.75671704
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71484284
82	Flat capital femoral epiphysis (HP:0003370)	1.71332160
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.69526696
84	Increased intramyocellular lipid droplets (HP:0012240)	1.68928573
85	Abnormality of T cell number (HP:0011839)	1.68457010
86	Hypoplasia of the thymus (HP:0000778)	1.67512266
87	Abnormal number of erythroid precursors (HP:0012131)	1.67258389
88	Limb hypertonia (HP:0002509)	1.66088323
89	Hypothermia (HP:0002045)	1.65902662
90	T lymphocytopenia (HP:0005403)	1.65739388
91	Disproportionate short-trunk short stature (HP:0003521)	1.65658058
92	Abnormality of cells of the erythroid lineage (HP:0012130)	1.65198610
93	Macrocytic anemia (HP:0001972)	1.64372563
94	Stenosis of the external auditory canal (HP:0000402)	1.63799475
95	Abnormality of T cell physiology (HP:0011840)	1.62480305
96	Medial flaring of the eyebrow (HP:0010747)	1.62170194
97	Absent thumb (HP:0009777)	1.61677798
98	Hyperglycinuria (HP:0003108)	1.61466253
99	Cerebral hypomyelination (HP:0006808)	1.60188398
100	Increased IgM level (HP:0003496)	1.59534822

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.81930047
2	FRK	3.42369298
3	MST4	3.20943146
4	BMPR1B	2.83355462
5	MAP3K12	2.80572496
6	BMPR2	2.70390373
7	NUAK1	2.44636532
8	GRK1	2.43662572
9	ZAK	2.33894330
10	ADRBK2	2.28793663
11	EIF2AK3	2.24014756
12	TLK1	2.16376346
13	VRK2	2.14797294
14	WNK3	1.99074405
15	TAOK3	1.79754479
16	BUB1	1.69837468
17	MAP4K1	1.60853518
18	TAF1	1.60775959
19	NME2	1.60646639
20	OXSR1	1.59226366
21	TNIK	1.54956670
22	STK16	1.52637954
23	EIF2AK1	1.48319233
24	ACVR1B	1.41551183
25	BRSK2	1.35966475
26	TRIM28	1.31226233
27	AKT3	1.29516685
28	STK39	1.27399707
29	PLK4	1.24657213
30	WNK4	1.22376773
31	BCKDK	1.12732047
32	NEK1	1.08047192
33	MYLK	1.07854792
34	MAP2K6	1.06062656
35	IKBKB	1.05789671
36	CAMKK2	1.04109747
37	VRK1	1.03618140
38	CASK	1.03354228
39	TEC	0.99146310
40	PLK3	0.93738673
41	PRKCQ	0.91527587
42	INSRR	0.88103304
43	PINK1	0.86075638
44	MUSK	0.84096874
45	FES	0.82659473
46	EIF2AK2	0.80054680
47	ITK	0.78674924
48	CDK19	0.78487768
49	PDK2	0.78257607
50	DAPK2	0.77699530
51	WEE1	0.75157864
52	MAPK13	0.75040990
53	MAP4K2	0.74843994
54	DYRK2	0.68978202
55	NME1	0.68359061
56	STK3	0.66707595
57	MKNK2	0.64914920
58	BRSK1	0.64814376
59	PRKCE	0.62702259
60	PLK2	0.60622467
61	PRKCG	0.59570755
62	RIPK4	0.57359887
63	DAPK1	0.57228018
64	CDC7	0.56364827
65	ADRBK1	0.54395229
66	SYK	0.53898726
67	PHKG2	0.52672625
68	PHKG1	0.52672625
69	PIK3CG	0.50821723
70	ERBB3	0.48524386
71	TGFBR1	0.48419250
72	PBK	0.46490331
73	DAPK3	0.45830620
74	PLK1	0.45500146
75	PRKACA	0.44921886
76	CSNK1G3	0.44498617
77	FLT3	0.43423912
78	CSNK1G1	0.43302788
79	CSNK2A1	0.43237636
80	CSNK1A1L	0.42913910
81	IKBKE	0.41527641
82	CSNK2A2	0.40594252
83	ATM	0.40401448
84	BTK	0.40290614
85	GRK5	0.39934449
86	OBSCN	0.39440260
87	CSNK1A1	0.37958285
88	KIT	0.37947695
89	GRK7	0.36363074
90	PRKCA	0.36296538
91	ATR	0.35979245
92	NLK	0.35835999
93	PRKG1	0.34654984
94	CHEK2	0.34552668
95	RPS6KA5	0.34468709
96	TSSK6	0.33659166
97	MKNK1	0.31830386
98	CAMK2A	0.31189177
99	EPHA3	0.30573183
100	CSNK1G2	0.30368246

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.71141266
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.12925829
3	Ribosome_Homo sapiens_hsa03010	2.94594110
4	Allograft rejection_Homo sapiens_hsa05330	2.68186069
5	Asthma_Homo sapiens_hsa05310	2.65342478
6	Protein export_Homo sapiens_hsa03060	2.62702729
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.57405486
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56249222
9	Parkinsons disease_Homo sapiens_hsa05012	2.50326245
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.48672043
11	RNA polymerase_Homo sapiens_hsa03020	2.34733720
12	Homologous recombination_Homo sapiens_hsa03440	2.17357263
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14947097
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.13702678
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.00164855
16	One carbon pool by folate_Homo sapiens_hsa00670	1.92799772
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86643436
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73635965
19	RNA degradation_Homo sapiens_hsa03018	1.72199810
20	Huntingtons disease_Homo sapiens_hsa05016	1.71031038
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66347585
22	Alzheimers disease_Homo sapiens_hsa05010	1.50689399
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.50017625
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43646868
25	Caffeine metabolism_Homo sapiens_hsa00232	1.38673134
26	Propanoate metabolism_Homo sapiens_hsa00640	1.38187290
27	Basal transcription factors_Homo sapiens_hsa03022	1.37656035
28	Phototransduction_Homo sapiens_hsa04744	1.33055188
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32123699
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29380190
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28026966
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27087263
33	Mismatch repair_Homo sapiens_hsa03430	1.25963552
34	Non-homologous end-joining_Homo sapiens_hsa03450	1.25518375
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.22395783
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.16167495
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13361822
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12126840
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10108927
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.09579111
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08246367
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07060262
43	RNA transport_Homo sapiens_hsa03013	1.05959452
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05606553
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01516174
46	Folate biosynthesis_Homo sapiens_hsa00790	1.01453153
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.94921257
48	Butanoate metabolism_Homo sapiens_hsa00650	0.91645589
49	Sulfur relay system_Homo sapiens_hsa04122	0.88802699
50	Purine metabolism_Homo sapiens_hsa00230	0.87026597
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83352594
52	Regulation of autophagy_Homo sapiens_hsa04140	0.81950205
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.79419490
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78533838
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78310402
56	Base excision repair_Homo sapiens_hsa03410	0.75702175
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75423132
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.75365694
59	Retinol metabolism_Homo sapiens_hsa00830	0.73256337
60	Spliceosome_Homo sapiens_hsa03040	0.72460875
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72180780
62	Olfactory transduction_Homo sapiens_hsa04740	0.71443164
63	Peroxisome_Homo sapiens_hsa04146	0.69832736
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66435525
65	Viral myocarditis_Homo sapiens_hsa05416	0.65550869
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65390048
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64505226
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63616257
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63497622
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.63465535
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61765003
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61122219
73	Metabolic pathways_Homo sapiens_hsa01100	0.59508193
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57522027
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56470349
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56462866
77	DNA replication_Homo sapiens_hsa03030	0.55495989
78	Sulfur metabolism_Homo sapiens_hsa00920	0.54804935
79	Mineral absorption_Homo sapiens_hsa04978	0.54486356
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.53850766
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53559484
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52491573
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.50159473
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49961634
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.47790974
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47636057
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47129545
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46562938
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44629205
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41188675
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40563346
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39475521
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37398129
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36694243
95	Fatty acid degradation_Homo sapiens_hsa00071	0.34465906
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33803603
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30322631
98	Glutathione metabolism_Homo sapiens_hsa00480	0.29478035
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28875811
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28565921

RPL23AP18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »