ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.09582075
2	activated T cell proliferation (GO:0050798)	7.78376326
3	positive regulation of glycoprotein biosynthetic process (GO:0010560)	7.71034605
4	regulation of protein glycosylation (GO:0060049)	7.00756964
5	positive regulation of glycoprotein metabolic process (GO:1903020)	6.37364678
6	transcription from RNA polymerase I promoter (GO:0006360)	5.72979313
7	ncRNA 3-end processing (GO:0043628)	5.38755629
8	diacylglycerol metabolic process (GO:0046339)	5.05238556
9	regulation of regulatory T cell differentiation (GO:0045589)	4.97430051
10	ribosomal small subunit biogenesis (GO:0042274)	4.79574411
11	heterotypic cell-cell adhesion (GO:0034113)	4.78577132
12	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.67940899
13	negative regulation of execution phase of apoptosis (GO:1900118)	4.67650855
14	viral transcription (GO:0019083)	4.35587748
15	regulation of metalloenzyme activity (GO:0048552)	4.25531413
16	xenobiotic catabolic process (GO:0042178)	4.17300920
17	translational termination (GO:0006415)	4.03051568
18	ubiquinone biosynthetic process (GO:0006744)	3.88528922
19	maturation of SSU-rRNA (GO:0030490)	3.81556320
20	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.64370604
21	translational elongation (GO:0006414)	3.55240641
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54961387
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54961387
24	NADH dehydrogenase complex assembly (GO:0010257)	3.54961387
25	protein polyglutamylation (GO:0018095)	3.54114980
26	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.52333643
27	deoxyribose phosphate biosynthetic process (GO:0046385)	3.52333643
28	cellular anion homeostasis (GO:0030002)	3.50961060
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.48830580
30	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.48373045
31	ubiquinone metabolic process (GO:0006743)	3.47501727
32	nonmotile primary cilium assembly (GO:0035058)	3.45117762
33	cotranslational protein targeting to membrane (GO:0006613)	3.44763157
34	eosinophil chemotaxis (GO:0048245)	3.42675345
35	isoprenoid biosynthetic process (GO:0008299)	3.42636810
36	protein targeting to ER (GO:0045047)	3.40270398
37	leukocyte cell-cell adhesion (GO:0007159)	3.39075354
38	ATP synthesis coupled proton transport (GO:0015986)	3.38856889
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.38856889
40	chaperone-mediated protein transport (GO:0072321)	3.37459736
41	protein localization to endoplasmic reticulum (GO:0070972)	3.34147207
42	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.34047034
43	embryonic body morphogenesis (GO:0010172)	3.33317836
44	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.32658459
45	oxygen transport (GO:0015671)	3.31028708
46	protein-cofactor linkage (GO:0018065)	3.24518186
47	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.22472759
48	regulation of interleukin-8 secretion (GO:2000482)	3.20971316
49	termination of RNA polymerase I transcription (GO:0006363)	3.19964270
50	water-soluble vitamin biosynthetic process (GO:0042364)	3.17816193
51	response to nitrosative stress (GO:0051409)	3.15468753
52	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	3.13696264
53	protein heterotetramerization (GO:0051290)	3.13042998
54	quinone biosynthetic process (GO:1901663)	3.12914955
55	endodermal cell differentiation (GO:0035987)	3.11764963
56	eosinophil migration (GO:0072677)	3.11158182
57	DNA deamination (GO:0045006)	3.10662606
58	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.05015873
59	glycerophospholipid catabolic process (GO:0046475)	3.04753602
60	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.04119331
61	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.99582409
62	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.94569334
63	regulation of immunoglobulin secretion (GO:0051023)	2.92124209
64	viral life cycle (GO:0019058)	2.91454064
65	protein complex biogenesis (GO:0070271)	2.90594054
66	positive regulation of calcium-mediated signaling (GO:0050850)	2.89300393
67	cellular protein complex disassembly (GO:0043624)	2.88526121
68	translational initiation (GO:0006413)	2.86547792
69	disruption of cells of other organism (GO:0044364)	2.83400672
70	killing of cells of other organism (GO:0031640)	2.83400672
71	spermatid nucleus differentiation (GO:0007289)	2.81521003
72	gas transport (GO:0015669)	2.81049717
73	regulation of glycoprotein biosynthetic process (GO:0010559)	2.76785017
74	acrosome assembly (GO:0001675)	2.75516993
75	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.74475424
76	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.73749009
77	regulation of lipoprotein metabolic process (GO:0050746)	2.71451897
78	arachidonic acid secretion (GO:0050482)	2.71185491
79	icosanoid secretion (GO:0032309)	2.71185491
80	defense response to fungus (GO:0050832)	2.71054230
81	receptor clustering (GO:0043113)	2.69292451
82	autophagic vacuole fusion (GO:0000046)	2.66641951
83	regulation of isotype switching to IgG isotypes (GO:0048302)	2.65622370
84	positive regulation of fatty acid oxidation (GO:0046321)	2.63693712
85	positive regulation of organelle assembly (GO:1902117)	2.63207819
86	formation of translation preinitiation complex (GO:0001731)	2.62310073
87	translation (GO:0006412)	2.61504394
88	response to misfolded protein (GO:0051788)	2.60437941
89	GPI anchor metabolic process (GO:0006505)	2.55949414
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.55893320
91	body morphogenesis (GO:0010171)	2.55190543
92	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.53186663
93	granulocyte chemotaxis (GO:0071621)	2.52350612
94	cellular defense response (GO:0006968)	2.52111463
95	histone H2B ubiquitination (GO:0033523)	2.51281830
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51157303
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50612622
98	positive regulation of Ras protein signal transduction (GO:0046579)	2.49739899
99	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.49572167
100	regulation of chronic inflammatory response (GO:0002676)	2.48324495

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.97321317
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.39597245
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.35134405
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.97633554
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82525998
6	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.72714852
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.71044464
8	VDR_22108803_ChIP-Seq_LS180_Human	2.62360043
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.59302376
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.59058979
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.56108482
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.45847957
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.34949171
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.32453364
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.09772904
16	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.96078304
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.85046844
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84182228
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.80140655
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.68547215
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.64161258
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63315421
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59687766
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.54436893
25	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.52872902
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49320875
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.48833272
28	TAF2_19829295_ChIP-Seq_ESCs_Human	1.43117506
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.43094248
30	GATA3_26560356_Chip-Seq_TH2_Human	1.41978830
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41331211
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.39891449
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37044301
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.34716566
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34385635
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32581934
37	GATA1_22025678_ChIP-Seq_K562_Human	1.30007687
38	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.24738525
39	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.23606539
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23553013
41	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21346960
42	RBPJ_21746931_ChIP-Seq_IB4_Human	1.20652450
43	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.18272106
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17786618
45	SA1_27219007_Chip-Seq_Bcells_Human	1.17711790
46	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.17502867
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15970439
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12868360
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.12571517
50	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.11196182
51	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.11196182
52	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.11196182
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.11117384
54	PHF8_20622853_ChIP-Seq_HELA_Human	1.10489629
55	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.10112627
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.09563564
57	MYC_19829295_ChIP-Seq_ESCs_Human	1.06612676
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06431555
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06431555
60	GATA3_26560356_Chip-Seq_TH1_Human	1.06300841
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06222472
62	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.05570751
63	EZH2_22144423_ChIP-Seq_EOC_Human	1.04459332
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04325223
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04080818
66	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02803397
67	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02523819
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02324959
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02324517
70	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.02036165
71	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.01451623
72	ERA_21632823_ChIP-Seq_H3396_Human	1.00844216
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99650291
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98837384
75	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97597384
76	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97588403
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97192917
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93536184
79	BCOR_27268052_Chip-Seq_Bcells_Human	0.93466421
80	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92302724
81	AR_20517297_ChIP-Seq_VCAP_Human	0.92113597
82	P300_27268052_Chip-Seq_Bcells_Human	0.90646093
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89837664
84	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.88698315
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.88533714
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88365831
87	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.88232986
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87792068
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87727865
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.87063685
91	SPI1_20517297_ChIP-Seq_HL60_Human	0.86239716
92	PHF8_20622854_ChIP-Seq_HELA_Human	0.85925692
93	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.85018012
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.83418267
95	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.82840426
96	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82761625
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82520604
98	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.81504930
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80903960
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.80844107

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.18141612
2	MP0002933_joint_inflammation	3.07138588
3	MP0004147_increased_porphyrin_level	3.01882120
4	MP0005671_abnormal_response_to	2.86063884
5	MP0004885_abnormal_endolymph	2.55023871
6	MP0001835_abnormal_antigen_presentation	2.52898052
7	MP0010386_abnormal_urinary_bladder	2.49441852
8	MP0005646_abnormal_pituitary_gland	2.41803632
9	MP0006082_CNS_inflammation	2.33815305
10	MP0003878_abnormal_ear_physiology	2.29935083
11	MP0005377_hearing/vestibular/ear_phenot	2.29935083
12	MP0004142_abnormal_muscle_tone	2.28770433
13	MP0001529_abnormal_vocalization	2.27180424
14	MP0009379_abnormal_foot_pigmentation	2.21861192
15	MP0002163_abnormal_gland_morphology	2.19321670
16	MP0001905_abnormal_dopamine_level	2.10251059
17	MP0001851_eye_inflammation	2.09965739
18	MP0001873_stomach_inflammation	2.08034128
19	MP0005670_abnormal_white_adipose	2.03777483
20	MP0003011_delayed_dark_adaptation	1.98362940
21	MP0002277_abnormal_respiratory_mucosa	1.91611913
22	MP0006292_abnormal_olfactory_placode	1.91038960
23	MP0008872_abnormal_physiological_respon	1.87161731
24	MP0008875_abnormal_xenobiotic_pharmacok	1.82669977
25	MP0001800_abnormal_humoral_immune	1.75191276
26	MP0005000_abnormal_immune_tolerance	1.74591645
27	MP0004947_skin_inflammation	1.74222664
28	MP0002148_abnormal_hypersensitivity_rea	1.70791709
29	MP0001727_abnormal_embryo_implantation	1.68296020
30	MP0005253_abnormal_eye_physiology	1.61109174
31	MP0003567_abnormal_fetal_cardiomyocyte	1.52028993
32	MP0002723_abnormal_immune_serum	1.49612144
33	MP0005025_abnormal_response_to	1.48494207
34	MP0006035_abnormal_mitochondrial_morpho	1.44018959
35	MP0000685_abnormal_immune_system	1.41868630
36	MP0008260_abnormal_autophagy	1.41792157
37	MP0002876_abnormal_thyroid_physiology	1.40886355
38	MP0004381_abnormal_hair_follicle	1.36447921
39	MP0001790_abnormal_immune_system	1.34771366
40	MP0005387_immune_system_phenotype	1.34771366
41	MP0003195_calcinosis	1.34182524
42	MP0006036_abnormal_mitochondrial_physio	1.31896633
43	MP0005595_abnormal_vascular_smooth	1.31276699
44	MP0003866_abnormal_defecation	1.30608558
45	MP0005197_abnormal_uvea_morphology	1.27022028
46	MP0002452_abnormal_antigen_presenting	1.26289932
47	MP0003724_increased_susceptibility_to	1.25703793
48	MP0005636_abnormal_mineral_homeostasis	1.24720569
49	MP0004145_abnormal_muscle_electrophysio	1.24154219
50	MP0000230_abnormal_systemic_arterial	1.23938292
51	MP0001502_abnormal_circadian_rhythm	1.18886646
52	MP0001191_abnormal_skin_condition	1.18418311
53	MP0002420_abnormal_adaptive_immunity	1.17268537
54	MP0003763_abnormal_thymus_physiology	1.16470818
55	MP0009785_altered_susceptibility_to	1.16283613
56	MP0002095_abnormal_skin_pigmentation	1.16246197
57	MP0001819_abnormal_immune_cell	1.12378684
58	MP0002419_abnormal_innate_immunity	1.11320260
59	MP0000538_abnormal_urinary_bladder	1.10670644
60	MP0009046_muscle_twitch	1.08336144
61	MP0005379_endocrine/exocrine_gland_phen	1.07149171
62	MP0001440_abnormal_grooming_behavior	1.06467467
63	MP0008877_abnormal_DNA_methylation	1.05463413
64	MP0008469_abnormal_protein_level	1.05140450
65	MP0001845_abnormal_inflammatory_respons	1.04633062
66	MP0000015_abnormal_ear_pigmentation	1.03700208
67	MP0005386_behavior/neurological_phenoty	1.02811773
68	MP0004924_abnormal_behavior	1.02811773
69	MP0001986_abnormal_taste_sensitivity	1.01265598
70	MP0001853_heart_inflammation	0.99856791
71	MP0005551_abnormal_eye_electrophysiolog	0.97782078
72	MP0002398_abnormal_bone_marrow	0.96146117
73	MP0002877_abnormal_melanocyte_morpholog	0.95609446
74	MP0000465_gastrointestinal_hemorrhage	0.93216214
75	MP0000367_abnormal_coat/_hair	0.92684771
76	MP0005448_abnormal_energy_balance	0.90927413
77	MP0003045_fibrosis	0.89754231
78	MP0002138_abnormal_hepatobiliary_system	0.89136025
79	MP0000716_abnormal_immune_system	0.88332756
80	MP0000689_abnormal_spleen_morphology	0.82644341
81	MP0000703_abnormal_thymus_morphology	0.82108203
82	MP0001293_anophthalmia	0.81006104
83	MP0001324_abnormal_eye_pigmentation	0.80156385
84	MP0008873_increased_physiological_sensi	0.77589465
85	MP0001663_abnormal_digestive_system	0.77367820
86	MP0005075_abnormal_melanosome_morpholog	0.76967655
87	MP0005381_digestive/alimentary_phenotyp	0.76940651
88	MP0002837_dystrophic_cardiac_calcinosis	0.76189560
89	MP0002722_abnormal_immune_system	0.75949665
90	MP0002405_respiratory_system_inflammati	0.74160898
91	MP0009745_abnormal_behavioral_response	0.73638535
92	MP0001765_abnormal_ion_homeostasis	0.72002506
93	MP0003186_abnormal_redox_activity	0.71749244
94	MP0003436_decreased_susceptibility_to	0.71267233
95	MP0005195_abnormal_posterior_eye	0.70884574
96	MP0002160_abnormal_reproductive_system	0.70605902
97	MP0002429_abnormal_blood_cell	0.70604745
98	MP0003137_abnormal_impulse_conducting	0.69699989
99	MP0009333_abnormal_splenocyte_physiolog	0.68909032
100	MP0008775_abnormal_heart_ventricle	0.67047177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Recurrent gram-negative bacterial infections (HP:0005420)	7.89835699
2	Periodontitis (HP:0000704)	6.17626408
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.12498506
4	Sparse scalp hair (HP:0002209)	4.75011090
5	Chronic bronchitis (HP:0004469)	4.70121894
6	Leukocytosis (HP:0001974)	4.59232125
7	Recurrent abscess formation (HP:0002722)	4.48368224
8	Acute necrotizing encephalopathy (HP:0006965)	4.45210674
9	Gingivitis (HP:0000230)	4.23776963
10	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.09337332
11	Abnormality of the intervertebral disk (HP:0005108)	3.96825711
12	3-Methylglutaconic aciduria (HP:0003535)	3.92984630
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.88499501
14	Progressive macrocephaly (HP:0004481)	3.72052343
15	Increased IgM level (HP:0003496)	3.71574973
16	Acute encephalopathy (HP:0006846)	3.65104865
17	Nasal speech (HP:0001611)	3.47641402
18	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.44094099
19	Autoimmune hemolytic anemia (HP:0001890)	3.37021326
20	Attenuation of retinal blood vessels (HP:0007843)	3.32554702
21	Cerebellar dysplasia (HP:0007033)	3.29711202
22	Hypoproteinemia (HP:0003075)	3.21890473
23	Eosinophilia (HP:0001880)	3.16347399
24	Abnormality of macular pigmentation (HP:0008002)	3.16053654
25	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.14330715
26	Maternal diabetes (HP:0009800)	3.08100723
27	Hypochromic anemia (HP:0001931)	3.05254919
28	Autoimmune thrombocytopenia (HP:0001973)	3.04717533
29	Abnormal hemoglobin (HP:0011902)	3.03926344
30	Microcytic anemia (HP:0001935)	2.96751923
31	Deep philtrum (HP:0002002)	2.95027965
32	Mitochondrial inheritance (HP:0001427)	2.94490799
33	Optic disc pallor (HP:0000543)	2.87630768
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76932527
35	Stomatitis (HP:0010280)	2.71987196
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.65281566
37	Increased CSF lactate (HP:0002490)	2.62239647
38	Abnormality of eosinophils (HP:0001879)	2.60298100
39	Hyperglycinemia (HP:0002154)	2.46789820
40	Cerebral edema (HP:0002181)	2.46262822
41	Granulocytopenia (HP:0001913)	2.39474504
42	Rhinitis (HP:0012384)	2.38160486
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.38065773
44	Bronchitis (HP:0012387)	2.32296200
45	Abnormality of T cell number (HP:0011839)	2.31122380
46	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29531820
47	Congenital stationary night blindness (HP:0007642)	2.29214783
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24394654
49	Cupped ribs (HP:0000887)	2.24357097
50	Abolished electroretinogram (ERG) (HP:0000550)	2.21504863
51	Pallor (HP:0000980)	2.20561397
52	Abnormal number of erythroid precursors (HP:0012131)	2.20545947
53	Hypoplastic toenails (HP:0001800)	2.19522178
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.18394153
55	Asplenia (HP:0001746)	2.17188242
56	Absent hand (HP:0004050)	2.16633003
57	Recurrent otitis media (HP:0000403)	2.14976788
58	Constricted visual fields (HP:0001133)	2.09732359
59	Hepatocellular necrosis (HP:0001404)	2.09603395
60	Reticulocytopenia (HP:0001896)	2.06711574
61	Hypoplasia of the uterus (HP:0000013)	2.05503065
62	IgG deficiency (HP:0004315)	2.02530325
63	Bronchiectasis (HP:0002110)	2.00502762
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.00057401
65	Cone-rod dystrophy (HP:0000548)	1.95530027
66	Muscle fiber atrophy (HP:0100295)	1.94956984
67	Increased serum lactate (HP:0002151)	1.94401704
68	Congenital, generalized hypertrichosis (HP:0004540)	1.92450146
69	Abnormality of magnesium homeostasis (HP:0004921)	1.91748943
70	Status epilepticus (HP:0002133)	1.90712361
71	Anencephaly (HP:0002323)	1.90022512
72	Panhypogammaglobulinemia (HP:0003139)	1.88780148
73	Macrocytic anemia (HP:0001972)	1.85331244
74	Abnormality of T cell physiology (HP:0011840)	1.82909022
75	Hepatic necrosis (HP:0002605)	1.79372098
76	Abnormality of midbrain morphology (HP:0002418)	1.79063449
77	Molar tooth sign on MRI (HP:0002419)	1.79063449
78	Partial agenesis of the corpus callosum (HP:0001338)	1.77796838
79	Cortical visual impairment (HP:0100704)	1.75571678
80	Abnormality of the fovea (HP:0000493)	1.74236375
81	Type II lissencephaly (HP:0007260)	1.73180298
82	Lethargy (HP:0001254)	1.72109222
83	Pendular nystagmus (HP:0012043)	1.70729786
84	Papilledema (HP:0001085)	1.70387713
85	Encephalitis (HP:0002383)	1.70011559
86	Hemiplegia (HP:0002301)	1.69759329
87	Alveolar cell carcinoma (HP:0006519)	1.69587847
88	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.68099696
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.67916313
90	Leukodystrophy (HP:0002415)	1.67824936
91	Methylmalonic acidemia (HP:0002912)	1.67801440
92	Lipid accumulation in hepatocytes (HP:0006561)	1.67057448
93	Chorioretinal atrophy (HP:0000533)	1.66825080
94	Abnormality of DNA repair (HP:0003254)	1.66743190
95	Abnormality of T cells (HP:0002843)	1.66494614
96	Hypoplasia of the fovea (HP:0007750)	1.64833963
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.64833963
98	Amelogenesis imperfecta (HP:0000705)	1.63809321
99	Nonprogressive disorder (HP:0003680)	1.63758384
100	Increased hepatocellular lipid droplets (HP:0006565)	1.63653045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	6.72049595
2	PRKCH	5.39674648
3	TXK	4.43408620
4	MAP4K1	4.15812091
5	TAOK3	3.57500962
6	FES	2.88745460
7	DAPK1	2.53356370
8	TYRO3	2.45896811
9	ZAK	2.22513722
10	GRK1	1.93739127
11	ADRBK2	1.82950225
12	ICK	1.62089458
13	CSK	1.58019311
14	ADRBK1	1.47536339
15	TLK1	1.45891655
16	EPHA3	1.44449737
17	PRKCQ	1.39282213
18	LCK	1.31718094
19	MAP4K2	1.27652513
20	STK16	1.26723569
21	NTRK3	1.24443422
22	IKBKB	1.16496665
23	DYRK2	1.15871615
24	FRK	1.11035795
25	MAPKAPK3	1.10517320
26	TEC	1.06651139
27	NUAK1	1.03354936
28	NME2	0.96300159
29	MAP3K11	0.93409228
30	MAP2K6	0.91881217
31	ITK	0.86975160
32	IRAK1	0.86313605
33	BCKDK	0.86052870
34	INSRR	0.85685561
35	RPS6KA2	0.84855316
36	PIK3CG	0.84289378
37	MAPK13	0.83114223
38	ABL2	0.82804231
39	PHKG2	0.79103354
40	PHKG1	0.79103354
41	RPS6KA6	0.77869763
42	CSF1R	0.77566976
43	WNK4	0.77145298
44	BMPR1B	0.76240973
45	RPS6KA5	0.71452131
46	MAPK4	0.71330134
47	MAP3K8	0.69636369
48	PRKCD	0.69625473
49	SYK	0.68283913
50	CAMK2A	0.68053537
51	MAP3K12	0.67387365
52	RPS6KC1	0.66688335
53	RPS6KL1	0.66688335
54	FLT3	0.66518078
55	CAMK2G	0.64319511
56	CAMK2D	0.63662501
57	PDK2	0.61919468
58	CAMKK2	0.61762174
59	VRK2	0.61554141
60	TSSK6	0.61059647
61	STK4	0.57530181
62	PRKCG	0.56655608
63	EIF2AK1	0.55583053
64	BTK	0.55098901
65	CAMK2B	0.54222481
66	JAK3	0.53940200
67	PDK1	0.53868179
68	PRKCB	0.52595863
69	MAP2K1	0.52461055
70	ALK	0.51645865
71	RPS6KB1	0.50253951
72	NLK	0.49451462
73	OXSR1	0.49418078
74	PRKACA	0.46482680
75	RET	0.46432820
76	VRK1	0.46422320
77	WNK3	0.43682969
78	IGF1R	0.43454697
79	OBSCN	0.40403879
80	MAP3K2	0.39463757
81	PRKCA	0.38421373
82	LYN	0.37924884
83	BMPR2	0.37784764
84	KSR2	0.37036692
85	KDR	0.36922689
86	CSNK2A2	0.35722516
87	CSNK1A1	0.33623673
88	GSK3A	0.32824039
89	PTK6	0.32194490
90	CSNK1E	0.32016592
91	ERBB2	0.31997241
92	TIE1	0.31475986
93	PAK3	0.31230349
94	ATM	0.30685380
95	PIK3CA	0.29145867
96	HCK	0.27964015
97	ZAP70	0.27734215
98	SRC	0.26712547
99	ATR	0.26517687
100	MAPK3	0.25857622

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	5.82116068
2	Ribosome_Homo sapiens_hsa03010	3.40541386
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.08042232
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.86736829
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.82362662
6	Allograft rejection_Homo sapiens_hsa05330	2.73332795
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.45687071
8	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.42243176
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.39023265
10	Viral myocarditis_Homo sapiens_hsa05416	2.34138534
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26545265
12	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.23939042
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21164982
14	Malaria_Homo sapiens_hsa05144	2.18531195
15	Parkinsons disease_Homo sapiens_hsa05012	2.13264317
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.02371699
17	Legionellosis_Homo sapiens_hsa05134	1.88631147
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.83495196
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.73699384
20	Leishmaniasis_Homo sapiens_hsa05140	1.66818635
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.61568971
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.60843417
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.58345549
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.50973352
25	Purine metabolism_Homo sapiens_hsa00230	1.46045327
26	Phototransduction_Homo sapiens_hsa04744	1.42625522
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38188606
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.36834055
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29918961
30	Huntingtons disease_Homo sapiens_hsa05016	1.29774960
31	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.28201782
32	Pertussis_Homo sapiens_hsa05133	1.10555945
33	Asthma_Homo sapiens_hsa05310	1.07950343
34	Proteasome_Homo sapiens_hsa03050	1.06533388
35	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.05885507
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.04282508
37	Basal transcription factors_Homo sapiens_hsa03022	1.03510836
38	Alzheimers disease_Homo sapiens_hsa05010	1.01678411
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98745477
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.98187006
41	Nicotine addiction_Homo sapiens_hsa05033	0.97806280
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97234512
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95947987
44	One carbon pool by folate_Homo sapiens_hsa00670	0.94623345
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88797785
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.88735143
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.88470211
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87709544
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.87162747
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85945264
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.83258749
52	Non-small cell lung cancer_Homo sapiens_hsa05223	0.81243816
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80634899
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79833115
55	Spliceosome_Homo sapiens_hsa03040	0.79315170
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78821167
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76752979
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75594685
59	Caffeine metabolism_Homo sapiens_hsa00232	0.75215725
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73252013
61	Measles_Homo sapiens_hsa05162	0.73241848
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73048250
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70289058
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62211461
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61430539
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61363681
67	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61269999
68	Olfactory transduction_Homo sapiens_hsa04740	0.56020605
69	RNA degradation_Homo sapiens_hsa03018	0.51884605
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48816342
71	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.46853767
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.45970664
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45140852
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44336251
75	ABC transporters_Homo sapiens_hsa02010	0.42950171
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41498938
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40750911
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39146561
79	Metabolic pathways_Homo sapiens_hsa01100	0.37793638
80	African trypanosomiasis_Homo sapiens_hsa05143	0.37436987
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33621321
82	Homologous recombination_Homo sapiens_hsa03440	0.33581031
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.30589573
84	Glutathione metabolism_Homo sapiens_hsa00480	0.28008163
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27511560
86	Ras signaling pathway_Homo sapiens_hsa04014	0.24902821
87	Tuberculosis_Homo sapiens_hsa05152	0.24852611
88	RNA transport_Homo sapiens_hsa03013	0.24723650
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.24328727
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.24048496
91	Retinol metabolism_Homo sapiens_hsa00830	0.20772136
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.19890334
93	Melanoma_Homo sapiens_hsa05218	0.17182059
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15872916
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.15159239
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.14509696
97	Serotonergic synapse_Homo sapiens_hsa04726	0.14495865
98	Morphine addiction_Homo sapiens_hsa05032	0.12376477
99	Phagosome_Homo sapiens_hsa04145	0.11993879
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.11979615

RPL23AP19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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