ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.99024886
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.83572427
3	cytidine deamination (GO:0009972)	6.81969475
4	cytidine metabolic process (GO:0046087)	6.81969475
5	cytidine catabolic process (GO:0006216)	6.81969475
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.90923136
7	positive thymic T cell selection (GO:0045059)	4.71004857
8	ribosomal small subunit assembly (GO:0000028)	4.69445005
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.48295948
10	positive T cell selection (GO:0043368)	4.35542739
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.09233647
12	ATP synthesis coupled proton transport (GO:0015986)	4.09233647
13	negative regulation of T cell apoptotic process (GO:0070233)	3.76350705
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.71769337
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70982534
16	sequestering of actin monomers (GO:0042989)	3.67025120
17	negative T cell selection (GO:0043383)	3.64898119
18	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.54922742
19	negative regulation by host of viral transcription (GO:0043922)	3.53865328
20	actin nucleation (GO:0045010)	3.51624280
21	respiratory electron transport chain (GO:0022904)	3.50656043
22	electron transport chain (GO:0022900)	3.48168980
23	response to pheromone (GO:0019236)	3.39091155
24	regulation of regulatory T cell differentiation (GO:0045589)	3.33535951
25	regulation of B cell receptor signaling pathway (GO:0050855)	3.30589014
26	viral transcription (GO:0019083)	3.24081672
27	regulation of activation of Janus kinase activity (GO:0010533)	3.20607244
28	positive regulation of B cell differentiation (GO:0045579)	3.19573111
29	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.17202496
30	translational termination (GO:0006415)	3.16581233
31	pyrimidine nucleoside catabolic process (GO:0046135)	3.12890599
32	T cell migration (GO:0072678)	3.09992792
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.09689818
34	positive regulation of calcium-mediated signaling (GO:0050850)	3.08755447
35	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.07057409
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.05837927
37	proteasome assembly (GO:0043248)	3.04662953
38	maturation of SSU-rRNA (GO:0030490)	3.04109344
39	translational elongation (GO:0006414)	3.02761999
40	negative thymic T cell selection (GO:0045060)	3.01996123
41	regulation of T cell receptor signaling pathway (GO:0050856)	3.00258832
42	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.98595494
43	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.96210134
44	response to interferon-beta (GO:0035456)	2.94541701
45	immunoglobulin mediated immune response (GO:0016064)	2.92359512
46	thymic T cell selection (GO:0045061)	2.91597831
47	protein targeting to ER (GO:0045047)	2.91247350
48	cotranslational protein targeting to membrane (GO:0006613)	2.90150090
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.88646862
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.88646862
51	protein neddylation (GO:0045116)	2.86305734
52	regulation of T cell mediated cytotoxicity (GO:0001914)	2.86112352
53	positive regulation of interleukin-8 secretion (GO:2000484)	2.85835864
54	cytolysis (GO:0019835)	2.85184453
55	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.84206666
56	protein complex biogenesis (GO:0070271)	2.83700947
57	regulation of B cell differentiation (GO:0045577)	2.83433338
58	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.82108400
59	behavioral response to nicotine (GO:0035095)	2.81927532
60	platelet dense granule organization (GO:0060155)	2.81238930
61	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.81110127
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.80214429
63	negative regulation of mast cell activation (GO:0033004)	2.80018311
64	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.79181096
65	protein localization to endoplasmic reticulum (GO:0070972)	2.77776526
66	negative regulation of viral genome replication (GO:0045071)	2.77193285
67	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.76232485
68	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.75229966
69	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73214572
70	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73214572
71	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73214572
72	T cell receptor signaling pathway (GO:0050852)	2.72978724
73	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71724501
74	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71724501
75	positive regulation of defense response to virus by host (GO:0002230)	2.71260599
76	positive regulation of prostaglandin secretion (GO:0032308)	2.68856704
77	mannosylation (GO:0097502)	2.68195784
78	positive regulation of gamma-delta T cell activation (GO:0046645)	2.68118157
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67565939
80	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.66104228
81	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.63795785
82	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.62718338
83	T cell selection (GO:0045058)	2.61802410
84	positive regulation of lymphocyte migration (GO:2000403)	2.61085820
85	DNA demethylation (GO:0080111)	2.59446594
86	mast cell activation (GO:0045576)	2.59225164
87	positive regulation of cell killing (GO:0031343)	2.58319482
88	regulation of alpha-beta T cell proliferation (GO:0046640)	2.57251039
89	hydrogen ion transmembrane transport (GO:1902600)	2.55566184
90	proton transport (GO:0015992)	2.55276189
91	regulation of interleukin-8 secretion (GO:2000482)	2.55001469
92	purine deoxyribonucleotide catabolic process (GO:0009155)	2.54735467
93	piRNA metabolic process (GO:0034587)	2.54499319
94	T cell costimulation (GO:0031295)	2.54013677
95	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.53520497
96	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.53472862
97	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.53472862
98	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.53284678
99	antigen receptor-mediated signaling pathway (GO:0050851)	2.52602148
100	lymphocyte costimulation (GO:0031294)	2.51295378

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.49754031
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.53794398
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.40566754
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.19466910
5	VDR_22108803_ChIP-Seq_LS180_Human	3.08954815
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93716351
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.77813757
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.76833991
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.75968123
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.73880686
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65506972
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64163962
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.55904316
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47024410
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.46010402
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42038844
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.38860841
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27349856
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.19886729
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99060789
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99011855
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97657341
23	MYB_26560356_Chip-Seq_TH2_Human	1.88165172
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86038896
25	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.84104534
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69593484
27	GATA3_26560356_Chip-Seq_TH2_Human	1.64756728
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61786550
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60350016
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58370448
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.56256624
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56133284
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.55634012
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55317224
35	GATA3_27048872_Chip-Seq_THYMUS_Human	1.51170916
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.51091497
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50957702
38	RUNX_20019798_ChIP-Seq_JUKART_Human	1.50841658
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45760456
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41436741
41	EWS_26573619_Chip-Seq_HEK293_Human	1.41085180
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39623330
43	AR_20517297_ChIP-Seq_VCAP_Human	1.38019880
44	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.37134826
45	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.37028850
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36963241
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36863314
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36863314
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.35308502
50	FUS_26573619_Chip-Seq_HEK293_Human	1.35026366
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31822577
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31822577
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29949839
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29132017
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28393466
56	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27299539
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.26484502
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24681649
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24394446
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24302947
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21507743
62	NCOR_22424771_ChIP-Seq_293T_Human	1.19869242
63	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.19370062
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15627275
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15078582
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14856968
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14332848
68	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13191471
69	P300_19829295_ChIP-Seq_ESCs_Human	1.12976205
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12910667
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12237513
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12219497
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10475490
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10152860
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09629437
76	TAF15_26573619_Chip-Seq_HEK293_Human	1.09447787
77	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.09202772
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08657586
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07246816
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.07246816
81	MYB_26560356_Chip-Seq_TH1_Human	1.05793101
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04046019
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03671051
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02865329
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02113632
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.01085076
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00184374
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97443546
89	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97229265
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95178948
91	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95081684
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.94964585
93	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94464208
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94336033
95	GBX2_23144817_ChIP-Seq_PC3_Human	0.93897356
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93072772
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89592419
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.89401911
99	GATA3_26560356_Chip-Seq_TH1_Human	0.88870750
100	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.88571128

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.88439877
2	MP0001835_abnormal_antigen_presentation	3.02421870
3	MP0009379_abnormal_foot_pigmentation	2.91172163
4	MP0009785_altered_susceptibility_to	2.86195459
5	MP0005645_abnormal_hypothalamus_physiol	2.29165813
6	MP0002148_abnormal_hypersensitivity_rea	2.27085129
7	MP0003763_abnormal_thymus_physiology	2.26673755
8	MP0001800_abnormal_humoral_immune	2.19307895
9	MP0000566_synostosis	2.15936366
10	MP0006072_abnormal_retinal_apoptosis	2.08503091
11	MP0005000_abnormal_immune_tolerance	2.08269303
12	MP0009333_abnormal_splenocyte_physiolog	2.08034667
13	MP0005075_abnormal_melanosome_morpholog	2.05412933
14	MP0005646_abnormal_pituitary_gland	1.96870486
15	MP0002102_abnormal_ear_morphology	1.93235489
16	MP0000685_abnormal_immune_system	1.86596464
17	MP0002723_abnormal_immune_serum	1.85601485
18	MP0002420_abnormal_adaptive_immunity	1.83607748
19	MP0008875_abnormal_xenobiotic_pharmacok	1.82864134
20	MP0002166_altered_tumor_susceptibility	1.79314529
21	MP0001819_abnormal_immune_cell	1.77881796
22	MP0000372_irregular_coat_pigmentation	1.75586941
23	MP0008872_abnormal_physiological_respon	1.72577723
24	MP0004147_increased_porphyrin_level	1.70550419
25	MP0001790_abnormal_immune_system	1.66713122
26	MP0005387_immune_system_phenotype	1.66713122
27	MP0005025_abnormal_response_to	1.62570635
28	MP0003866_abnormal_defecation	1.62315803
29	MP0002452_abnormal_antigen_presenting	1.61607248
30	MP0008995_early_reproductive_senescence	1.61378224
31	MP0005551_abnormal_eye_electrophysiolog	1.53898511
32	MP0003011_delayed_dark_adaptation	1.50587049
33	MP0003646_muscle_fatigue	1.47617441
34	MP0006082_CNS_inflammation	1.46647468
35	MP0002006_tumorigenesis	1.43226286
36	MP0000716_abnormal_immune_system	1.42925297
37	MP0002398_abnormal_bone_marrow	1.42119078
38	MP0006292_abnormal_olfactory_placode	1.39483528
39	MP0005253_abnormal_eye_physiology	1.35748746
40	MP0001873_stomach_inflammation	1.35669461
41	MP0001968_abnormal_touch/_nociception	1.35592532
42	MP0004145_abnormal_muscle_electrophysio	1.33852122
43	MP0010155_abnormal_intestine_physiology	1.31434449
44	MP0001919_abnormal_reproductive_system	1.30908479
45	MP0003806_abnormal_nucleotide_metabolis	1.30733640
46	MP0008877_abnormal_DNA_methylation	1.29267430
47	MP0001905_abnormal_dopamine_level	1.23518910
48	MP0005389_reproductive_system_phenotype	1.21219340
49	MP0003195_calcinosis	1.19655827
50	MP0002405_respiratory_system_inflammati	1.18956445
51	MP0002837_dystrophic_cardiac_calcinosis	1.18910659
52	MP0003786_premature_aging	1.16454755
53	MP0002234_abnormal_pharynx_morphology	1.16433181
54	MP0000689_abnormal_spleen_morphology	1.15791425
55	MP0002638_abnormal_pupillary_reflex	1.13528041
56	MP0003724_increased_susceptibility_to	1.13165946
57	MP0002736_abnormal_nociception_after	1.12061717
58	MP0002095_abnormal_skin_pigmentation	1.10950651
59	MP0002722_abnormal_immune_system	1.08112766
60	MP0000703_abnormal_thymus_morphology	1.07764497
61	MP0006276_abnormal_autonomic_nervous	1.06712327
62	MP0005410_abnormal_fertilization	1.06322213
63	MP0002933_joint_inflammation	1.05113519
64	MP0002429_abnormal_blood_cell	1.04600526
65	MP0001984_abnormal_olfaction	1.03176762
66	MP0004885_abnormal_endolymph	1.02045122
67	MP0001845_abnormal_inflammatory_respons	1.01740287
68	MP0004142_abnormal_muscle_tone	1.01481641
69	MP0002138_abnormal_hepatobiliary_system	1.01357472
70	MP0001764_abnormal_homeostasis	0.99532753
71	MP0002277_abnormal_respiratory_mucosa	0.99198256
72	MP0003880_abnormal_central_pattern	0.97120890
73	MP0002876_abnormal_thyroid_physiology	0.94655335
74	MP0009764_decreased_sensitivity_to	0.91158479
75	MP0000631_abnormal_neuroendocrine_gland	0.90890915
76	MP0005377_hearing/vestibular/ear_phenot	0.90348020
77	MP0003878_abnormal_ear_physiology	0.90348020
78	MP0002419_abnormal_innate_immunity	0.89224593
79	MP0008469_abnormal_protein_level	0.86977997
80	MP0001986_abnormal_taste_sensitivity	0.86630061
81	MP0002160_abnormal_reproductive_system	0.85404310
82	MP0001501_abnormal_sleep_pattern	0.85284089
83	MP0006036_abnormal_mitochondrial_physio	0.84285882
84	MP0005084_abnormal_gallbladder_morpholo	0.83962841
85	MP0008058_abnormal_DNA_repair	0.82988452
86	MP0001765_abnormal_ion_homeostasis	0.82963844
87	MP0001485_abnormal_pinna_reflex	0.81071198
88	MP0005464_abnormal_platelet_physiology	0.80983787
89	MP0002693_abnormal_pancreas_physiology	0.78731461
90	MP0003252_abnormal_bile_duct	0.76730756
91	MP0005423_abnormal_somatic_nervous	0.76288636
92	MP0003283_abnormal_digestive_organ	0.75373094
93	MP0001853_heart_inflammation	0.74983443
94	MP0005636_abnormal_mineral_homeostasis	0.74927283
95	MP0004742_abnormal_vestibular_system	0.73479918
96	MP0009763_increased_sensitivity_to	0.70975294
97	MP0010386_abnormal_urinary_bladder	0.69009793
98	MP0003137_abnormal_impulse_conducting	0.68249876
99	MP0000569_abnormal_digit_pigmentation	0.66472520
100	MP0009745_abnormal_behavioral_response	0.66372339

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.72537502
2	Congenital stationary night blindness (HP:0007642)	4.44249821
3	Severe combined immunodeficiency (HP:0004430)	3.92850767
4	Mitochondrial inheritance (HP:0001427)	3.80785642
5	IgG deficiency (HP:0004315)	3.79915299
6	3-Methylglutaconic aciduria (HP:0003535)	3.65597730
7	Hypoproteinemia (HP:0003075)	3.59908746
8	T lymphocytopenia (HP:0005403)	3.59477942
9	Acute necrotizing encephalopathy (HP:0006965)	3.59256614
10	Abnormality of T cell number (HP:0011839)	3.57471150
11	Abnormality of B cell number (HP:0010975)	3.54526905
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.44745103
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.36617571
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.31865464
15	Thyroiditis (HP:0100646)	3.27391404
16	Hepatocellular necrosis (HP:0001404)	3.23406150
17	Attenuation of retinal blood vessels (HP:0007843)	3.22915189
18	Increased CSF lactate (HP:0002490)	3.21066689
19	Progressive macrocephaly (HP:0004481)	3.19505610
20	Stomatitis (HP:0010280)	3.18085105
21	B lymphocytopenia (HP:0010976)	3.10044430
22	Increased hepatocellular lipid droplets (HP:0006565)	3.08276595
23	Acute encephalopathy (HP:0006846)	3.04308795
24	Increased intramyocellular lipid droplets (HP:0012240)	2.98856502
25	Combined immunodeficiency (HP:0005387)	2.94944749
26	Abnormality of T cells (HP:0002843)	2.92737157
27	Autoimmune hemolytic anemia (HP:0001890)	2.86663914
28	Lipid accumulation in hepatocytes (HP:0006561)	2.84197905
29	Hepatic necrosis (HP:0002605)	2.84012787
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.83900506
31	Abnormality of the prostate (HP:0008775)	2.81265957
32	Concave nail (HP:0001598)	2.77863155
33	Renal Fanconi syndrome (HP:0001994)	2.70835734
34	Optic disc pallor (HP:0000543)	2.68176938
35	Agammaglobulinemia (HP:0004432)	2.64572894
36	Increased IgM level (HP:0003496)	2.63378633
37	Pancreatic cysts (HP:0001737)	2.61971476
38	Abnormality of eosinophils (HP:0001879)	2.54409329
39	Decreased central vision (HP:0007663)	2.53286738
40	Abolished electroretinogram (ERG) (HP:0000550)	2.53160612
41	Panhypogammaglobulinemia (HP:0003139)	2.49937947
42	Increased muscle lipid content (HP:0009058)	2.49753442
43	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.46950834
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.46950834
45	Stomach cancer (HP:0012126)	2.44693193
46	True hermaphroditism (HP:0010459)	2.43167231
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.41202027
48	Cerebral edema (HP:0002181)	2.37541581
49	Abnormal number of erythroid precursors (HP:0012131)	2.36357825
50	Methylmalonic acidemia (HP:0002912)	2.30567955
51	Eosinophilia (HP:0001880)	2.25202979
52	Type II lissencephaly (HP:0007260)	2.25087174
53	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.24195599
54	Pancreatic fibrosis (HP:0100732)	2.23280344
55	Abnormality of cells of the erythroid lineage (HP:0012130)	2.23204599
56	Exertional dyspnea (HP:0002875)	2.16773166
57	Abnormality of midbrain morphology (HP:0002418)	2.16470507
58	Molar tooth sign on MRI (HP:0002419)	2.16470507
59	Pancytopenia (HP:0001876)	2.15904954
60	Renal cortical cysts (HP:0000803)	2.15772012
61	Increased serum lactate (HP:0002151)	2.12955277
62	Meningitis (HP:0001287)	2.12417632
63	Recurrent cutaneous fungal infections (HP:0011370)	2.06449547
64	Chronic mucocutaneous candidiasis (HP:0002728)	2.06449547
65	Encephalitis (HP:0002383)	2.06179199
66	Type 2 muscle fiber atrophy (HP:0003554)	2.05255793
67	Autoimmune thrombocytopenia (HP:0001973)	2.05057667
68	Type I transferrin isoform profile (HP:0003642)	2.03971199
69	Lactic acidosis (HP:0003128)	2.02162043
70	Chronic diarrhea (HP:0002028)	1.97689190
71	Constricted visual fields (HP:0001133)	1.96850301
72	Congenital, generalized hypertrichosis (HP:0004540)	1.96713576
73	Abnormality of T cell physiology (HP:0011840)	1.96604581
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96530559
75	Recurrent bronchitis (HP:0002837)	1.95440853
76	Leukocytosis (HP:0001974)	1.95271212
77	Lethargy (HP:0001254)	1.94404014
78	Methylmalonic aciduria (HP:0012120)	1.90748703
79	Medial flaring of the eyebrow (HP:0010747)	1.90717367
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90068690
81	Abnormality of the renal cortex (HP:0011035)	1.89845156
82	Oral leukoplakia (HP:0002745)	1.87447960
83	Chronic sinusitis (HP:0011109)	1.87258587
84	Recurrent corneal erosions (HP:0000495)	1.83023094
85	Increased corneal curvature (HP:0100692)	1.80089400
86	Keratoconus (HP:0000563)	1.80089400
87	IgM deficiency (HP:0002850)	1.78163736
88	Pendular nystagmus (HP:0012043)	1.75395619
89	Recurrent fungal infections (HP:0002841)	1.74838665
90	Respiratory failure (HP:0002878)	1.74295387
91	Hypoplasia of the thymus (HP:0000778)	1.73298643
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73006009
93	Pulmonary infiltrates (HP:0002113)	1.70366144
94	Stenosis of the external auditory canal (HP:0000402)	1.70115295
95	Abnormality of male internal genitalia (HP:0000022)	1.69765302
96	Macrocytic anemia (HP:0001972)	1.69306668
97	Granulocytopenia (HP:0001913)	1.69248211
98	Bronchitis (HP:0012387)	1.68371552
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.67167257
100	Ketosis (HP:0001946)	1.65015825

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.14015602
2	KDR	4.08921582
3	TESK2	3.65501082
4	TAOK3	2.94335498
5	ZAK	2.57168767
6	BCKDK	2.55149044
7	INSRR	2.47566049
8	PINK1	2.45192207
9	TLK1	2.37113060
10	ADRBK2	2.29304869
11	VRK2	2.24128687
12	NUAK1	2.06142934
13	GRK1	2.05710180
14	MAP4K1	2.05347025
15	MAP4K2	2.03300814
16	CDK19	1.99311844
17	ITK	1.95304109
18	MAP3K12	1.85113877
19	VRK1	1.82007875
20	FES	1.75376047
21	KIT	1.64686633
22	SYK	1.61059708
23	FRK	1.59239350
24	MST4	1.52637922
25	SCYL2	1.49318142
26	BUB1	1.48181053
27	TEC	1.43013910
28	PASK	1.36032365
29	GRK6	1.20123804
30	TNK2	1.17084396
31	WNK4	1.11602307
32	WNK3	1.07952097
33	EIF2AK3	1.06685192
34	ERBB3	1.06586069
35	BTK	1.00170349
36	PRKCQ	0.99136450
37	LCK	0.98176884
38	CSF1R	0.98041227
39	NME1	0.94955001
40	BMPR1B	0.94676947
41	OXSR1	0.91110259
42	MAP2K7	0.90290574
43	MAPKAPK3	0.88338227
44	LYN	0.87486337
45	MAP3K11	0.84617224
46	LIMK1	0.81789417
47	DAPK1	0.81478669
48	MAP3K4	0.79672579
49	IKBKB	0.79407731
50	TRPM7	0.79209028
51	RPS6KA5	0.77468488
52	GRK7	0.76776268
53	OBSCN	0.75347318
54	PIK3CG	0.74090393
55	STK16	0.73950293
56	BMPR2	0.72054357
57	MYLK	0.69592227
58	STK39	0.69319705
59	TAF1	0.68924940
60	TESK1	0.68171316
61	IKBKE	0.66286748
62	FGFR2	0.66276106
63	MUSK	0.65371205
64	CSK	0.62297781
65	TIE1	0.58222233
66	ADRBK1	0.57268850
67	CSNK1G3	0.57156721
68	MAPK13	0.57022218
69	DYRK2	0.54971893
70	MATK	0.54908235
71	MAP2K6	0.52759012
72	PHKG1	0.52563060
73	PHKG2	0.52563060
74	CLK1	0.52535199
75	HCK	0.52200947
76	FLT3	0.51533031
77	MAPK15	0.51399539
78	JAK3	0.51239771
79	PIM1	0.50904675
80	IGF1R	0.50399098
81	RPS6KA4	0.50308988
82	GRK5	0.49012579
83	PRKCA	0.42838911
84	ZAP70	0.42325000
85	DAPK3	0.40971817
86	TRIM28	0.40203955
87	TBK1	0.39155920
88	MAPKAPK5	0.38959233
89	CSNK2A1	0.38116993
90	PRKACA	0.37402819
91	AURKA	0.36924764
92	WEE1	0.36218519
93	CSNK1G1	0.35550235
94	NTRK3	0.33043822
95	PLK3	0.31346321
96	CSNK1G2	0.31141029
97	DAPK2	0.30219378
98	FYN	0.29918285
99	CSNK2A2	0.29417569
100	INSR	0.28558444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.38680851
2	Proteasome_Homo sapiens_hsa03050	3.68422587
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33146682
4	Ribosome_Homo sapiens_hsa03010	3.19428529
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.14880018
6	Allograft rejection_Homo sapiens_hsa05330	3.13497821
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.09405614
8	Asthma_Homo sapiens_hsa05310	2.71717140
9	Parkinsons disease_Homo sapiens_hsa05012	2.71244100
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.68462734
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.46242309
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.29875721
13	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.89895509
14	Alzheimers disease_Homo sapiens_hsa05010	1.82156242
15	RNA polymerase_Homo sapiens_hsa03020	1.81169695
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.78992937
17	Phototransduction_Homo sapiens_hsa04744	1.77033681
18	Caffeine metabolism_Homo sapiens_hsa00232	1.74926609
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.68167749
20	Protein export_Homo sapiens_hsa03060	1.66794932
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60715994
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.57910424
23	Huntingtons disease_Homo sapiens_hsa05016	1.57515903
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52233124
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.44727332
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.28339129
27	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.27549449
28	Homologous recombination_Homo sapiens_hsa03440	1.26271247
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17519477
30	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.17079776
31	Viral myocarditis_Homo sapiens_hsa05416	1.15391978
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11768341
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08344417
34	One carbon pool by folate_Homo sapiens_hsa00670	1.08195865
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01621424
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00277857
37	Olfactory transduction_Homo sapiens_hsa04740	0.98878831
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98827907
39	Peroxisome_Homo sapiens_hsa04146	0.93103168
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92575758
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90710768
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88833399
43	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.85636260
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84206800
45	RNA degradation_Homo sapiens_hsa03018	0.82876059
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80947551
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78174412
48	Purine metabolism_Homo sapiens_hsa00230	0.76333923
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75032099
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73383587
51	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.70638895
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69989441
53	Regulation of autophagy_Homo sapiens_hsa04140	0.69157471
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68880658
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68729582
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68362246
57	Leishmaniasis_Homo sapiens_hsa05140	0.68034548
58	Basal transcription factors_Homo sapiens_hsa03022	0.67604357
59	Retinol metabolism_Homo sapiens_hsa00830	0.65541198
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65516343
61	Measles_Homo sapiens_hsa05162	0.64572881
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.62532576
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62380010
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62041442
65	Mismatch repair_Homo sapiens_hsa03430	0.62034963
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61661295
67	Herpes simplex infection_Homo sapiens_hsa05168	0.60634776
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59515580
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59485663
70	Propanoate metabolism_Homo sapiens_hsa00640	0.57528596
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56877237
72	Taste transduction_Homo sapiens_hsa04742	0.54868484
73	Spliceosome_Homo sapiens_hsa03040	0.53486937
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52202508
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.52054843
76	Butanoate metabolism_Homo sapiens_hsa00650	0.51517028
77	Nicotine addiction_Homo sapiens_hsa05033	0.50272320
78	Malaria_Homo sapiens_hsa05144	0.48924158
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48747937
80	DNA replication_Homo sapiens_hsa03030	0.47310797
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46482547
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.45736933
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41875060
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41107136
85	Metabolic pathways_Homo sapiens_hsa01100	0.38674760
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38482079
87	Base excision repair_Homo sapiens_hsa03410	0.35841171
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.32926347
89	RNA transport_Homo sapiens_hsa03013	0.32230970
90	Salivary secretion_Homo sapiens_hsa04970	0.30766114
91	Salmonella infection_Homo sapiens_hsa05132	0.28344075
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25953849
93	Morphine addiction_Homo sapiens_hsa05032	0.25930430
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24907400
95	African trypanosomiasis_Homo sapiens_hsa05143	0.24603788
96	Shigellosis_Homo sapiens_hsa05131	0.23945037
97	Sulfur metabolism_Homo sapiens_hsa00920	0.23795778
98	Serotonergic synapse_Homo sapiens_hsa04726	0.19095509
99	Alcoholism_Homo sapiens_hsa05034	0.17761131
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.15860655

RPL23AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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