ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of chronic inflammatory response (GO:0002676)	5.88077712
2	positive regulation of granulocyte differentiation (GO:0030854)	5.43161151
3	DNA deamination (GO:0045006)	5.30852853
4	T-helper cell differentiation (GO:0042093)	4.88366880
5	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	4.88366880
6	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.80984312
7	negative regulation of cAMP-mediated signaling (GO:0043951)	4.80455783
8	response to mercury ion (GO:0046689)	4.53110476
9	ribosomal small subunit assembly (GO:0000028)	4.49753561
10	ribosomal small subunit biogenesis (GO:0042274)	4.49503546
11	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.45428859
12	urate metabolic process (GO:0046415)	4.36387478
13	viral transcription (GO:0019083)	4.34054715
14	histone H2A acetylation (GO:0043968)	4.33474204
15	alpha-beta T cell differentiation involved in immune response (GO:0002293)	4.31918221
16	alpha-beta T cell activation involved in immune response (GO:0002287)	4.31918221
17	T cell differentiation involved in immune response (GO:0002292)	4.31918221
18	translational termination (GO:0006415)	4.28522321
19	ribosomal large subunit biogenesis (GO:0042273)	4.22474458
20	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.09954743
21	phosphate ion transport (GO:0006817)	4.05536374
22	peptidyl-tyrosine autophosphorylation (GO:0038083)	4.00674201
23	maturation of SSU-rRNA (GO:0030490)	4.00104506
24	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.99758769
25	GTP biosynthetic process (GO:0006183)	3.98292254
26	regulation of interleukin-13 production (GO:0032656)	3.91598555
27	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.81389076
28	CTP metabolic process (GO:0046036)	3.80608824
29	CTP biosynthetic process (GO:0006241)	3.80608824
30	UTP biosynthetic process (GO:0006228)	3.79743997
31	regulation of immunoglobulin secretion (GO:0051023)	3.74729752
32	cotranslational protein targeting to membrane (GO:0006613)	3.73010427
33	translational elongation (GO:0006414)	3.72345546
34	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.68366099
35	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.68195273
36	protein targeting to ER (GO:0045047)	3.65721037
37	cytokine production involved in immune response (GO:0002367)	3.64025769
38	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.58493250
39	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.53642942
40	regulation of isotype switching to IgG isotypes (GO:0048302)	3.49406154
41	alanine transport (GO:0032328)	3.48767089
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.45214313
43	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.42415478
44	isotype switching (GO:0045190)	3.42415478
45	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.42415478
46	tachykinin receptor signaling pathway (GO:0007217)	3.41981931
47	protein localization to endoplasmic reticulum (GO:0070972)	3.41336694
48	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.35366421
49	UTP metabolic process (GO:0046051)	3.34365647
50	behavioral response to nicotine (GO:0035095)	3.33578890
51	regulation of uterine smooth muscle contraction (GO:0070472)	3.32853911
52	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.32040531
53	DNA methylation involved in gamete generation (GO:0043046)	3.22906468
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.22704232
55	cellular protein complex disassembly (GO:0043624)	3.21993169
56	maturation of 5.8S rRNA (GO:0000460)	3.18932660
57	positive regulation of activated T cell proliferation (GO:0042104)	3.18059318
58	ribonucleoprotein complex biogenesis (GO:0022613)	3.15819826
59	folic acid metabolic process (GO:0046655)	3.13479697
60	positive regulation of DNA recombination (GO:0045911)	3.11895439
61	rRNA modification (GO:0000154)	3.11007932
62	trivalent inorganic anion homeostasis (GO:0072506)	3.10346268
63	phosphate ion homeostasis (GO:0055062)	3.10346268
64	rRNA methylation (GO:0031167)	3.06643170
65	interferon-gamma production (GO:0032609)	3.04042975
66	negative regulation of nitric oxide biosynthetic process (GO:0045019)	3.03718656
67	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.03472435
68	alpha-beta T cell differentiation (GO:0046632)	3.03329366
69	rRNA processing (GO:0006364)	3.00472267
70	viral life cycle (GO:0019058)	3.00355122
71	rRNA metabolic process (GO:0016072)	2.99149057
72	methionine biosynthetic process (GO:0009086)	2.98867876
73	regulation of granulocyte differentiation (GO:0030852)	2.95600217
74	CD4-positive, alpha-beta T cell differentiation (GO:0043367)	2.93437468
75	oxidative demethylation (GO:0070989)	2.93394358
76	meiotic chromosome segregation (GO:0045132)	2.92096516
77	phosphate ion transmembrane transport (GO:0035435)	2.90552451
78	protein-cofactor linkage (GO:0018065)	2.88949329
79	positive regulation of immunoglobulin production (GO:0002639)	2.86667904
80	pentose metabolic process (GO:0019321)	2.85631281
81	positive regulation of isotype switching (GO:0045830)	2.83944901
82	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.83482790
83	aminoglycoside antibiotic metabolic process (GO:0030647)	2.83294578
84	translation (GO:0006412)	2.83213474
85	aspartate family amino acid biosynthetic process (GO:0009067)	2.82930529
86	rRNA transcription (GO:0009303)	2.81701354
87	cellular response to interleukin-15 (GO:0071350)	2.80104190
88	T cell lineage commitment (GO:0002360)	2.80051847
89	CD4-positive, alpha-beta T cell activation (GO:0035710)	2.79723735
90	T cell mediated immunity (GO:0002456)	2.78243537
91	negative regulation of heart rate (GO:0010459)	2.77382036
92	deoxyribose phosphate biosynthetic process (GO:0046385)	2.77210638
93	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.77210638
94	piRNA metabolic process (GO:0034587)	2.76247570
95	translational initiation (GO:0006413)	2.76221977
96	regulation of gamma-delta T cell differentiation (GO:0045586)	2.73603331
97	regulation of hippo signaling (GO:0035330)	2.73480882
98	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.71339888
99	mucosal-associated lymphoid tissue development (GO:0048537)	2.69659470
100	Peyers patch development (GO:0048541)	2.69659470

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.14279709
2	GATA1_22025678_ChIP-Seq_K562_Human	6.95810303
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.64430243
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.00535842
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.68474488
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51203929
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42388927
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39809919
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31510868
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31097860
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.25163361
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.04333224
13	RUNX_20019798_ChIP-Seq_JUKART_Human	1.99502681
14	MYC_18940864_ChIP-ChIP_HL60_Human	1.89665585
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.88258577
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86785927
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.82449743
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.80941599
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.71242077
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.60067353
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.59764421
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.55451520
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55268108
24	NCOR_22424771_ChIP-Seq_293T_Human	1.48633115
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48178420
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.47685261
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.46340826
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40277765
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.37325436
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.36684381
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35668862
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32175057
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.31958852
34	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31722294
35	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.31661947
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.30093481
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28207851
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26310737
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25763003
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.25295739
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.24271597
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21773989
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21773989
44	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.21033362
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20982190
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19152675
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18829380
48	GATA3_26560356_Chip-Seq_TH2_Human	1.18441915
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.17614407
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17371810
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17371810
52	MYB_26560356_Chip-Seq_TH2_Human	1.16012121
53	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.14900819
54	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.12408253
55	BCL6_27268052_Chip-Seq_Bcells_Human	1.12202201
56	EWS_26573619_Chip-Seq_HEK293_Human	1.11663155
57	SPI1_20517297_ChIP-Seq_HL60_Human	1.11558159
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09244764
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09027193
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08832440
61	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.06884071
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06673305
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06124906
64	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05326996
65	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03512388
66	FUS_26573619_Chip-Seq_HEK293_Human	1.03214789
67	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02690109
68	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02271971
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99689660
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98713394
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98497349
72	STAT1_20625510_ChIP-Seq_HELA_Human	0.98443709
73	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98203750
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98116992
75	ELK1_19687146_ChIP-ChIP_HELA_Human	0.96494952
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94593802
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94271005
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93099862
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92325763
80	ER_23166858_ChIP-Seq_MCF-7_Human	0.92000618
81	ERA_21632823_ChIP-Seq_H3396_Human	0.90777540
82	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.90451007
83	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.90068735
84	XRN2_22483619_ChIP-Seq_HELA_Human	0.89881913
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89847889
86	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.89400311
87	SMRT_27268052_Chip-Seq_Bcells_Human	0.89196089
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88967280
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88514793
90	SA1_27219007_Chip-Seq_Bcells_Human	0.87767652
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.87511960
92	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.86711562
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85459854
94	ZNF263_19887448_ChIP-Seq_K562_Human	0.85045045
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.84717135
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84299065
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83141592
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81867974
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.80778988
100	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.80195934

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.57276335
2	MP0005377_hearing/vestibular/ear_phenot	5.57276335
3	MP0001348_abnormal_lacrimal_gland	4.67987515
4	MP0003646_muscle_fatigue	3.69148217
5	MP0005645_abnormal_hypothalamus_physiol	3.34033932
6	MP0004145_abnormal_muscle_electrophysio	2.98049803
7	MP0008875_abnormal_xenobiotic_pharmacok	2.64399097
8	MP0002163_abnormal_gland_morphology	2.63518206
9	MP0002102_abnormal_ear_morphology	2.55333432
10	MP0000685_abnormal_immune_system	2.46044648
11	MP0001501_abnormal_sleep_pattern	2.39015629
12	MP0001873_stomach_inflammation	2.34435836
13	MP0003763_abnormal_thymus_physiology	2.23515448
14	MP0004381_abnormal_hair_follicle	2.19467938
15	MP0002160_abnormal_reproductive_system	2.17081517
16	MP0005671_abnormal_response_to	2.15287234
17	MP0008872_abnormal_physiological_respon	2.04781952
18	MP0006292_abnormal_olfactory_placode	2.00855121
19	MP0001835_abnormal_antigen_presentation	1.84899570
20	MP0004147_increased_porphyrin_level	1.80691047
21	MP0001984_abnormal_olfaction	1.72807851
22	MP0002837_dystrophic_cardiac_calcinosis	1.69202254
23	MP0002138_abnormal_hepatobiliary_system	1.67164289
24	MP0005389_reproductive_system_phenotype	1.59647883
25	MP0003045_fibrosis	1.52712222
26	MP0004858_abnormal_nervous_system	1.49655651
27	MP0005379_endocrine/exocrine_gland_phen	1.49620057
28	MP0003136_yellow_coat_color	1.46476646
29	MP0009333_abnormal_splenocyte_physiolog	1.46343693
30	MP0001764_abnormal_homeostasis	1.45733221
31	MP0009785_altered_susceptibility_to	1.45459030
32	MP0001790_abnormal_immune_system	1.41015829
33	MP0005387_immune_system_phenotype	1.41015829
34	MP0001485_abnormal_pinna_reflex	1.38279733
35	MP0005551_abnormal_eye_electrophysiolog	1.36722831
36	MP0003786_premature_aging	1.34684870
37	MP0002653_abnormal_ependyma_morphology	1.32351701
38	MP0000427_abnormal_hair_cycle	1.31144647
39	MP0003693_abnormal_embryo_hatching	1.29351396
40	MP0001800_abnormal_humoral_immune	1.26067624
41	MP0008877_abnormal_DNA_methylation	1.23876228
42	MP0001486_abnormal_startle_reflex	1.21528287
43	MP0002148_abnormal_hypersensitivity_rea	1.20561904
44	MP0001963_abnormal_hearing_physiology	1.19414393
45	MP0004142_abnormal_muscle_tone	1.18115251
46	MP0004019_abnormal_vitamin_homeostasis	1.17410674
47	MP0009046_muscle_twitch	1.16845985
48	MP0002272_abnormal_nervous_system	1.06680792
49	MP0005646_abnormal_pituitary_gland	1.05046844
50	MP0010094_abnormal_chromosome_stability	1.04381869
51	MP0009379_abnormal_foot_pigmentation	1.03359737
52	MP0002006_tumorigenesis	1.03264041
53	MP0005075_abnormal_melanosome_morpholog	1.03209824
54	MP0005000_abnormal_immune_tolerance	1.01889572
55	MP0005319_abnormal_enzyme/_coenzyme	1.00173688
56	MP0000026_abnormal_inner_ear	0.99657458
57	MP0006072_abnormal_retinal_apoptosis	0.96050871
58	MP0002723_abnormal_immune_serum	0.96007908
59	MP0003806_abnormal_nucleotide_metabolis	0.95963055
60	MP0005025_abnormal_response_to	0.95590077
61	MP0006036_abnormal_mitochondrial_physio	0.94937007
62	MP0003195_calcinosis	0.93061342
63	MP0000703_abnormal_thymus_morphology	0.92550628
64	MP0002398_abnormal_bone_marrow	0.92040145
65	MP0002420_abnormal_adaptive_immunity	0.88130151
66	MP0004885_abnormal_endolymph	0.85819830
67	MP0005253_abnormal_eye_physiology	0.84240116
68	MP0002332_abnormal_exercise_endurance	0.83599680
69	MP0001970_abnormal_pain_threshold	0.83420525
70	MP0001819_abnormal_immune_cell	0.83155646
71	MP0001919_abnormal_reproductive_system	0.82471112
72	MP0006082_CNS_inflammation	0.81406942
73	MP0000604_amyloidosis	0.80723862
74	MP0002735_abnormal_chemical_nociception	0.78643547
75	MP0002733_abnormal_thermal_nociception	0.77800452
76	MP0006276_abnormal_autonomic_nervous	0.77171769
77	MP0005310_abnormal_salivary_gland	0.76390789
78	MP0002229_neurodegeneration	0.74692463
79	MP0001529_abnormal_vocalization	0.74662425
80	MP0000716_abnormal_immune_system	0.73617487
81	MP0002452_abnormal_antigen_presenting	0.73070210
82	MP0002722_abnormal_immune_system	0.72120893
83	MP0000678_abnormal_parathyroid_gland	0.70600131
84	MP0005332_abnormal_amino_acid	0.69795168
85	MP0010386_abnormal_urinary_bladder	0.69579314
86	MP0003959_abnormal_lean_body	0.69575082
87	MP0002166_altered_tumor_susceptibility	0.68344586
88	MP0008469_abnormal_protein_level	0.68038026
89	MP0009745_abnormal_behavioral_response	0.67001143
90	MP0001765_abnormal_ion_homeostasis	0.65349447
91	MP0002429_abnormal_blood_cell	0.63317984
92	MP0005397_hematopoietic_system_phenotyp	0.61453687
93	MP0001545_abnormal_hematopoietic_system	0.61453687
94	MP0001986_abnormal_taste_sensitivity	0.61165549
95	MP0001881_abnormal_mammary_gland	0.60907194
96	MP0002405_respiratory_system_inflammati	0.60363878
97	MP0009765_abnormal_xenobiotic_induced	0.59984866
98	MP0005195_abnormal_posterior_eye	0.57477917
99	MP0005171_absent_coat_pigmentation	0.55452397
100	MP0000689_abnormal_spleen_morphology	0.55018998

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	5.18645326
2	Aplastic anemia (HP:0001915)	4.69374725
3	Congenital stationary night blindness (HP:0007642)	4.44135364
4	Generalized aminoaciduria (HP:0002909)	4.30852311
5	Pigmentary retinal degeneration (HP:0001146)	3.81338048
6	Severe visual impairment (HP:0001141)	3.75568932
7	Homocystinuria (HP:0002156)	3.50612201
8	Abnormality of homocysteine metabolism (HP:0010919)	3.50612201
9	Stomatitis (HP:0010280)	3.40342330
10	Pancreatic cysts (HP:0001737)	3.35233537
11	Dyschromatopsia (HP:0007641)	3.18338833
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.12066134
13	3-Methylglutaconic aciduria (HP:0003535)	3.07123557
14	Increased IgM level (HP:0003496)	3.05055769
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98793692
16	IgG deficiency (HP:0004315)	2.79033140
17	Parakeratosis (HP:0001036)	2.77438116
18	Abnormality of methionine metabolism (HP:0010901)	2.72960369
19	Abnormal number of erythroid precursors (HP:0012131)	2.71664290
20	Proximal tubulopathy (HP:0000114)	2.71444160
21	Macrocytic anemia (HP:0001972)	2.65943247
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.63299673
23	Increased corneal curvature (HP:0100692)	2.62929098
24	Keratoconus (HP:0000563)	2.62929098
25	Acute necrotizing encephalopathy (HP:0006965)	2.58259514
26	True hermaphroditism (HP:0010459)	2.51569269
27	Gastrointestinal infarctions (HP:0005244)	2.47825416
28	Absent thumb (HP:0009777)	2.45741805
29	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.45626313
30	Popliteal pterygium (HP:0009756)	2.42495036
31	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.39726947
32	Abnormality of the labia minora (HP:0012880)	2.39698929
33	Neonatal respiratory distress (HP:0002643)	2.39073338
34	Attenuation of retinal blood vessels (HP:0007843)	2.38414522
35	Palpitations (HP:0001962)	2.37572137
36	Abnormality of the renal cortex (HP:0011035)	2.36115166
37	Colon cancer (HP:0003003)	2.33763487
38	Mitochondrial inheritance (HP:0001427)	2.33583030
39	Chorioretinal atrophy (HP:0000533)	2.33475191
40	Abnormality of the renal collecting system (HP:0004742)	2.32249777
41	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.29194558
42	Amelogenesis imperfecta (HP:0000705)	2.27608163
43	Abnormality of T cell physiology (HP:0011840)	2.27039353
44	Submucous cleft hard palate (HP:0000176)	2.26547596
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25318601
46	Type 2 muscle fiber atrophy (HP:0003554)	2.25054406
47	Abnormality of vitamin B metabolism (HP:0004340)	2.24027066
48	Overlapping toe (HP:0001845)	2.22058582
49	Acute encephalopathy (HP:0006846)	2.19494139
50	Unilateral renal agenesis (HP:0000122)	2.18893933
51	Impaired proprioception (HP:0010831)	2.16438355
52	Myokymia (HP:0002411)	2.14412679
53	Hypoproteinemia (HP:0003075)	2.12745049
54	Constricted visual fields (HP:0001133)	2.12573851
55	Pancreatic fibrosis (HP:0100732)	2.11614939
56	Autoimmune hemolytic anemia (HP:0001890)	2.10615294
57	Glycosuria (HP:0003076)	2.08856518
58	Abnormality of urine glucose concentration (HP:0011016)	2.08856518
59	Abnormality of T cells (HP:0002843)	2.08492410
60	Congenital, generalized hypertrichosis (HP:0004540)	2.07637099
61	Central scotoma (HP:0000603)	2.06283123
62	Abnormal number of incisors (HP:0011064)	2.05521135
63	Decreased circulating renin level (HP:0003351)	2.04925428
64	Muscle fiber atrophy (HP:0100295)	2.04689847
65	Abnormality of placental membranes (HP:0011409)	2.02552785
66	Amniotic constriction ring (HP:0009775)	2.02552785
67	Clumsiness (HP:0002312)	2.02494736
68	Paralysis (HP:0003470)	2.02464148
69	Progressive macrocephaly (HP:0004481)	2.01637392
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01141982
71	Aplasia/Hypoplasia of the patella (HP:0006498)	2.00889562
72	Abnormality of T cell number (HP:0011839)	2.00735206
73	Reticulocytopenia (HP:0001896)	2.00685078
74	Hypokalemic alkalosis (HP:0001949)	1.97317379
75	Abolished electroretinogram (ERG) (HP:0000550)	1.95379131
76	Hypoplasia of the uterus (HP:0000013)	1.95191172
77	Autoimmune thrombocytopenia (HP:0001973)	1.95012986
78	Cystic liver disease (HP:0006706)	1.93804190
79	Genetic anticipation (HP:0003743)	1.87658326
80	Hepatic necrosis (HP:0002605)	1.87134479
81	Increased intramyocellular lipid droplets (HP:0012240)	1.86566671
82	Sclerocornea (HP:0000647)	1.85247867
83	Megaloblastic anemia (HP:0001889)	1.84039733
84	Pallor (HP:0000980)	1.83732269
85	Abnormal biliary tract physiology (HP:0012439)	1.83723347
86	Bile duct proliferation (HP:0001408)	1.83723347
87	Alkalosis (HP:0001948)	1.82977748
88	Acute lymphatic leukemia (HP:0006721)	1.82728236
89	Abnormality of DNA repair (HP:0003254)	1.81966924
90	Increased CSF lactate (HP:0002490)	1.81008753
91	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.78933523
92	J-shaped sella turcica (HP:0002680)	1.77806416
93	Abnormality of the middle phalanges of the toes (HP:0010183)	1.76698414
94	T lymphocytopenia (HP:0005403)	1.76604570
95	Squamous cell carcinoma (HP:0002860)	1.76032369
96	Type II lissencephaly (HP:0007260)	1.75833187
97	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.75122190
98	Hepatocellular necrosis (HP:0001404)	1.74597327
99	Hypokalemia (HP:0002900)	1.74364795
100	Stenosis of the external auditory canal (HP:0000402)	1.74131428

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	7.11437744
2	PRKD3	3.71804813
3	PASK	3.49319366
4	MAP4K1	3.30199411
5	ADRBK2	3.24902400
6	MAP3K12	2.80965701
7	CDK19	2.77173281
8	FRK	2.69010307
9	NLK	2.57210743
10	WNK4	2.25494244
11	TAOK3	2.09321503
12	PBK	1.98112268
13	BCKDK	1.87086060
14	ZAK	1.86226078
15	VRK2	1.78122513
16	GRK1	1.68148173
17	MAP4K2	1.68123194
18	OXSR1	1.63036932
19	NUAK1	1.53914202
20	STK39	1.48501406
21	GRK7	1.36147943
22	AURKA	1.29504151
23	TLK1	1.23316774
24	NME1	1.20762323
25	NEK1	1.18950387
26	MAP3K11	1.18825223
27	GRK6	1.14164970
28	IKBKB	1.09019135
29	SCYL2	1.07664945
30	JAK3	1.06667397
31	MAP2K2	1.00657715
32	EIF2AK3	0.96455443
33	STK38L	0.96253015
34	IKBKE	0.95204504
35	RPS6KA6	0.93283172
36	ITK	0.92576714
37	TGFBR1	0.90261590
38	TRIM28	0.89043923
39	SYK	0.88053047
40	DAPK1	0.87366602
41	ADRBK1	0.84114254
42	CDK8	0.83868826
43	VRK1	0.83597235
44	RPS6KL1	0.82308862
45	RPS6KC1	0.82308862
46	CHEK2	0.80866495
47	SRPK1	0.80517701
48	LATS2	0.80354129
49	LATS1	0.79259554
50	CAMKK1	0.78278385
51	BMPR1B	0.77607295
52	PRKCG	0.75517550
53	TAF1	0.70246378
54	DYRK2	0.68982111
55	EIF2AK1	0.68934097
56	STK11	0.66793352
57	EIF2AK2	0.63883543
58	PRKCD	0.63513422
59	FGFR2	0.62877988
60	LCK	0.62684884
61	DAPK3	0.62415782
62	GRK5	0.61564985
63	TNIK	0.61416087
64	CSNK1G3	0.61214269
65	PHKG1	0.61168115
66	PHKG2	0.61168115
67	CSF1R	0.60467746
68	BUB1	0.57527679
69	BTK	0.56911110
70	PIK3CG	0.56525084
71	PIM1	0.55817243
72	PAK1	0.54646618
73	INSRR	0.54452904
74	PRKCH	0.54141792
75	PLK1	0.51707843
76	LYN	0.49268212
77	PRKACA	0.48551219
78	CSNK1A1L	0.47600805
79	MUSK	0.46956890
80	MELK	0.44609706
81	PRKCB	0.44111488
82	PLK3	0.43185722
83	MOS	0.42427591
84	IGF1R	0.41768775
85	CSNK2A1	0.37794243
86	MAPKAPK5	0.37707907
87	PRKG1	0.37541539
88	CHEK1	0.37337446
89	PRKAA2	0.36425690
90	CSNK1G1	0.35404640
91	FES	0.35046226
92	IRAK4	0.35006894
93	TSSK6	0.34028307
94	PRKCA	0.33723062
95	LRRK2	0.33373161
96	KDR	0.33000509
97	OBSCN	0.31241448
98	TIE1	0.29859947
99	AURKB	0.28639329
100	RPS6KA4	0.28408468

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.44767462
2	Asthma_Homo sapiens_hsa05310	3.48305669
3	Proteasome_Homo sapiens_hsa03050	3.19978014
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12309784
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.74766306
6	Allograft rejection_Homo sapiens_hsa05330	2.62889792
7	One carbon pool by folate_Homo sapiens_hsa00670	2.62150192
8	Phototransduction_Homo sapiens_hsa04744	2.49345637
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.47426476
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.46221754
11	Sulfur relay system_Homo sapiens_hsa04122	2.22808629
12	Nicotine addiction_Homo sapiens_hsa05033	2.17287330
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.96321367
14	Renin-angiotensin system_Homo sapiens_hsa04614	1.88910390
15	Protein export_Homo sapiens_hsa03060	1.80494205
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.75299797
17	Homologous recombination_Homo sapiens_hsa03440	1.71291063
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.70311819
19	RNA polymerase_Homo sapiens_hsa03020	1.69418186
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.65458126
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60095450
22	Caffeine metabolism_Homo sapiens_hsa00232	1.59572037
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.56631300
24	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.49315584
25	Parkinsons disease_Homo sapiens_hsa05012	1.45768811
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45696188
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.44801051
28	Taste transduction_Homo sapiens_hsa04742	1.43646842
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37105333
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36650817
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.34056526
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.33570823
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31323471
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29694331
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27873397
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.20950553
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.20738036
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15139458
39	Retinol metabolism_Homo sapiens_hsa00830	1.10690508
40	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09506902
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08460714
42	RNA degradation_Homo sapiens_hsa03018	1.07722344
43	Mismatch repair_Homo sapiens_hsa03430	1.04379782
44	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.03508480
45	Morphine addiction_Homo sapiens_hsa05032	1.01947701
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01359058
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98803976
48	Alzheimers disease_Homo sapiens_hsa05010	0.98680138
49	Antigen processing and presentation_Homo sapiens_hsa04612	0.96225831
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94185349
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93211453
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92494484
53	Olfactory transduction_Homo sapiens_hsa04740	0.91461457
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89199288
55	Basal transcription factors_Homo sapiens_hsa03022	0.86567738
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85175725
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81563515
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.80482310
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76324641
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75698607
61	Butanoate metabolism_Homo sapiens_hsa00650	0.70445465
62	Spliceosome_Homo sapiens_hsa03040	0.70434352
63	Purine metabolism_Homo sapiens_hsa00230	0.69783597
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.68405555
65	Malaria_Homo sapiens_hsa05144	0.68001778
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65755930
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64714094
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63498222
69	GABAergic synapse_Homo sapiens_hsa04727	0.63442496
70	Huntingtons disease_Homo sapiens_hsa05016	0.63274448
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60575497
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60345647
73	DNA replication_Homo sapiens_hsa03030	0.58263464
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57060985
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56312412
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51629536
77	African trypanosomiasis_Homo sapiens_hsa05143	0.50217541
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.46717595
79	Metabolic pathways_Homo sapiens_hsa01100	0.45037452
80	Arginine biosynthesis_Homo sapiens_hsa00220	0.44854864
81	Sulfur metabolism_Homo sapiens_hsa00920	0.43475150
82	RNA transport_Homo sapiens_hsa03013	0.40830980
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40031627
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37973149
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36937745
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36188799
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.35975112
88	Viral myocarditis_Homo sapiens_hsa05416	0.35567249
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35476124
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.35283572
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.34591424
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32942436
93	Measles_Homo sapiens_hsa05162	0.30859239
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30640185
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28884981
96	Salivary secretion_Homo sapiens_hsa04970	0.27454329
97	Circadian rhythm_Homo sapiens_hsa04710	0.26686714
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26605643
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25943905
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23032271

RPL23AP20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »