ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.76180439
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.07178452
3	regulation of meiosis I (GO:0060631)	4.93713309
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.85573621
5	ATP synthesis coupled proton transport (GO:0015986)	4.85573621
6	terpenoid biosynthetic process (GO:0016114)	4.80824002
7	positive regulation of mitochondrial fission (GO:0090141)	4.42878557
8	DNA double-strand break processing (GO:0000729)	4.32852947
9	negative regulation of appetite (GO:0032099)	4.19636945
10	negative regulation of response to food (GO:0032096)	4.19636945
11	positive regulation of catecholamine secretion (GO:0033605)	4.00638233
12	regulation of transmission of nerve impulse (GO:0051969)	3.95470977
13	maturation of 5.8S rRNA (GO:0000460)	3.90140059
14	rRNA modification (GO:0000154)	3.82023739
15	isoprenoid biosynthetic process (GO:0008299)	3.58663822
16	rRNA methylation (GO:0031167)	3.56559482
17	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.52980788
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48369054
19	regulation of mitochondrial fission (GO:0090140)	3.46255124
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.45641075
21	respiratory electron transport chain (GO:0022904)	3.41779011
22	electron transport chain (GO:0022900)	3.39246171
23	adult feeding behavior (GO:0008343)	3.36083512
24	protein targeting to mitochondrion (GO:0006626)	3.35618284
25	piRNA metabolic process (GO:0034587)	3.35358677
26	oxidative phosphorylation (GO:0006119)	3.34023324
27	base-excision repair, AP site formation (GO:0006285)	3.33628742
28	DNA methylation involved in gamete generation (GO:0043046)	3.32541704
29	ATP biosynthetic process (GO:0006754)	3.30165592
30	S-adenosylmethionine metabolic process (GO:0046500)	3.27452174
31	protein K11-linked ubiquitination (GO:0070979)	3.27028493
32	tRNA aminoacylation for protein translation (GO:0006418)	3.24200588
33	positive regulation of histone H3-K4 methylation (GO:0051571)	3.24056565
34	IMP biosynthetic process (GO:0006188)	3.21878588
35	DNA catabolic process, exonucleolytic (GO:0000738)	3.19491928
36	mannosylation (GO:0097502)	3.16875605
37	amino acid activation (GO:0043038)	3.16802394
38	tRNA aminoacylation (GO:0043039)	3.16802394
39	synapsis (GO:0007129)	3.15821858
40	protein localization to mitochondrion (GO:0070585)	3.14561390
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11839651
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11063908
43	protein K6-linked ubiquitination (GO:0085020)	3.09737035
44	establishment of protein localization to mitochondrion (GO:0072655)	3.07925297
45	male meiosis (GO:0007140)	3.06496148
46	pyrimidine nucleotide catabolic process (GO:0006244)	3.05317471
47	mismatch repair (GO:0006298)	3.04155893
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03940208
49	protein complex biogenesis (GO:0070271)	3.03625544
50	positive regulation of meiosis (GO:0045836)	3.03598292
51	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.00559342
52	histone mRNA metabolic process (GO:0008334)	2.99232004
53	protoporphyrinogen IX metabolic process (GO:0046501)	2.97294707
54	DNA replication checkpoint (GO:0000076)	2.96845681
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.94674583
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.94674583
57	NADH dehydrogenase complex assembly (GO:0010257)	2.94674583
58	negative regulation of telomere maintenance (GO:0032205)	2.94578170
59	purine nucleobase biosynthetic process (GO:0009113)	2.93508304
60	protein polyglutamylation (GO:0018095)	2.92173701
61	pseudouridine synthesis (GO:0001522)	2.90974975
62	tRNA modification (GO:0006400)	2.87376616
63	transcription from mitochondrial promoter (GO:0006390)	2.87338109
64	cellular protein catabolic process (GO:0044257)	2.86612826
65	response to nitrosative stress (GO:0051409)	2.85847079
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.85144755
67	mitochondrial RNA metabolic process (GO:0000959)	2.84591474
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.83727613
69	nucleobase biosynthetic process (GO:0046112)	2.83037393
70	IMP metabolic process (GO:0046040)	2.82912519
71	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.82867978
72	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.82867978
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81189858
74	positive regulation of meiotic cell cycle (GO:0051446)	2.80654198
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.79931050
76	negative regulation of bone resorption (GO:0045779)	2.79799796
77	regulation of response to food (GO:0032095)	2.79784609
78	tRNA metabolic process (GO:0006399)	2.77719184
79	viral mRNA export from host cell nucleus (GO:0046784)	2.75485662
80	cholesterol biosynthetic process (GO:0006695)	2.74584560
81	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.74452143
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74095669
83	termination of RNA polymerase III transcription (GO:0006386)	2.74095669
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.74033054
85	erythrocyte maturation (GO:0043249)	2.73596056
86	prenylation (GO:0097354)	2.72340013
87	protein prenylation (GO:0018342)	2.72340013
88	ribonucleoprotein complex disassembly (GO:0032988)	2.72154478
89	protein-cofactor linkage (GO:0018065)	2.71635375
90	peptidyl-histidine modification (GO:0018202)	2.70923579
91	organelle disassembly (GO:1903008)	2.69741473
92	protein neddylation (GO:0045116)	2.69420135
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.68649703
94	tRNA processing (GO:0008033)	2.65062826
95	regulation of translational elongation (GO:0006448)	2.64886895
96	pteridine-containing compound biosynthetic process (GO:0042559)	2.63823808
97	cysteine metabolic process (GO:0006534)	2.61712526
98	attachment of spindle microtubules to kinetochore (GO:0008608)	2.61284549
99	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.56259696
100	regulation of mitochondrial translation (GO:0070129)	2.55485815

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.74703220
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.42293525
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.17825169
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.40560241
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.22515689
6	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.01364149
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97441001
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.91223222
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.87195732
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84796904
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.76190393
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.65259949
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.62707749
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.49220607
15	E2F7_22180533_ChIP-Seq_HELA_Human	2.32171435
16	DCP1A_22483619_ChIP-Seq_HELA_Human	2.31597662
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31398139
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.29050518
19	VDR_22108803_ChIP-Seq_LS180_Human	2.21317223
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.20689292
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14621608
22	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.12851256
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09132667
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.08497808
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02962941
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.02081803
27	TTF2_22483619_ChIP-Seq_HELA_Human	2.00798352
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.99065069
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.93083574
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.92622429
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.90886804
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.89364452
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.86514166
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.84229435
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78499359
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.78327189
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.75145224
38	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.74471059
39	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.72134938
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.72089471
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70411388
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.64741938
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58310535
44	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.55970749
45	EWS_26573619_Chip-Seq_HEK293_Human	1.55155250
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54034036
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48873864
48	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.43755923
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43012797
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42406681
51	KDM5A_27292631_Chip-Seq_BREAST_Human	1.35507222
52	PHF8_20622853_ChIP-Seq_HELA_Human	1.35275056
53	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34878236
54	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.32674909
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.32338319
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.31861073
57	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30209901
58	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.29909124
59	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.28748800
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.26351163
61	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26309266
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22586693
63	ETV1_20927104_ChIP-Seq_GIST48_Human	1.18817961
64	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.16494723
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12847365
66	AR_21909140_ChIP-Seq_LNCAP_Human	1.12730710
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12528873
68	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.11269704
69	ZNF263_19887448_ChIP-Seq_K562_Human	1.10678057
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.07592349
71	NFYB_21822215_ChIP-Seq_K562_Human	1.06542751
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06207368
73	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05913399
74	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.05165057
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.04520154
76	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04360292
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02376553
78	FUS_26573619_Chip-Seq_HEK293_Human	1.00863300
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.98010989
80	NFYA_21822215_ChIP-Seq_K562_Human	0.97421604
81	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93728571
82	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92284887
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92206661
84	GATA1_22025678_ChIP-Seq_K562_Human	0.91622840
85	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.90177533
86	NCOR_22424771_ChIP-Seq_293T_Human	0.90057788
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89403738
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.88153243
89	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88139094
90	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88120850
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86190212
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84801982
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84801982
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84199738
95	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83851709
96	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.83328509
97	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.81513580
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81341225
99	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.81068647
100	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.81058295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.69833640
2	MP0004147_increased_porphyrin_level	4.43516319
3	MP0003786_premature_aging	3.37533928
4	MP0008877_abnormal_DNA_methylation	3.28274406
5	MP0008058_abnormal_DNA_repair	3.27233577
6	MP0008995_early_reproductive_senescence	2.82913862
7	MP0004957_abnormal_blastocyst_morpholog	2.71138935
8	MP0003693_abnormal_embryo_hatching	2.35073435
9	MP0002102_abnormal_ear_morphology	2.28056716
10	MP0006036_abnormal_mitochondrial_physio	2.24711077
11	MP0002837_dystrophic_cardiac_calcinosis	2.17332931
12	MP0001661_extended_life_span	2.07818849
13	MP0001529_abnormal_vocalization	2.07395437
14	MP0006072_abnormal_retinal_apoptosis	2.03236376
15	MP0003186_abnormal_redox_activity	2.00866000
16	MP0003718_maternal_effect	1.99422804
17	MP0004145_abnormal_muscle_electrophysio	1.94678480
18	MP0006035_abnormal_mitochondrial_morpho	1.93088044
19	MP0002938_white_spotting	1.87827106
20	MP0005084_abnormal_gallbladder_morpholo	1.86911016
21	MP0003111_abnormal_nucleus_morphology	1.75833145
22	MP0008932_abnormal_embryonic_tissue	1.65303864
23	MP0006276_abnormal_autonomic_nervous	1.65068148
24	MP0005171_absent_coat_pigmentation	1.64858664
25	MP0003646_muscle_fatigue	1.59702522
26	MP0010094_abnormal_chromosome_stability	1.58124839
27	MP0002210_abnormal_sex_determination	1.55498628
28	MP0005408_hypopigmentation	1.54318466
29	MP0005389_reproductive_system_phenotype	1.48458240
30	MP0009046_muscle_twitch	1.46114604
31	MP0001929_abnormal_gametogenesis	1.45932588
32	MP0004142_abnormal_muscle_tone	1.44928331
33	MP0002160_abnormal_reproductive_system	1.40021516
34	MP0003567_abnormal_fetal_cardiomyocyte	1.38161673
35	MP0001188_hyperpigmentation	1.36297074
36	MP0005332_abnormal_amino_acid	1.35825360
37	MP0003195_calcinosis	1.30565697
38	MP0008057_abnormal_DNA_replication	1.29074839
39	MP0003880_abnormal_central_pattern	1.27934469
40	MP0005253_abnormal_eye_physiology	1.23136560
41	MP0003077_abnormal_cell_cycle	1.20383608
42	MP0000358_abnormal_cell_content/	1.19560845
43	MP0000653_abnormal_sex_gland	1.19179446
44	MP0008007_abnormal_cellular_replicative	1.16464950
45	MP0004215_abnormal_myocardial_fiber	1.15550518
46	MP0000678_abnormal_parathyroid_gland	1.13819416
47	MP0008775_abnormal_heart_ventricle	1.13617644
48	MP0003698_abnormal_male_reproductive	1.13605174
49	MP0001919_abnormal_reproductive_system	1.13496155
50	MP0001145_abnormal_male_reproductive	1.13177682
51	MP0005174_abnormal_tail_pigmentation	1.12005703
52	MP0002229_neurodegeneration	1.10505931
53	MP0002095_abnormal_skin_pigmentation	1.10376478
54	MP0005083_abnormal_biliary_tract	1.08606310
55	MP0003656_abnormal_erythrocyte_physiolo	1.04889131
56	MP0003137_abnormal_impulse_conducting	1.04858308
57	MP0004885_abnormal_endolymph	1.03989385
58	MP0004233_abnormal_muscle_weight	1.03025978
59	MP0002138_abnormal_hepatobiliary_system	1.02415172
60	MP0005410_abnormal_fertilization	1.02002427
61	MP0000749_muscle_degeneration	1.01383384
62	MP0001984_abnormal_olfaction	1.00983597
63	MP0005645_abnormal_hypothalamus_physiol	0.99811162
64	MP0001542_abnormal_bone_strength	0.96720706
65	MP0004484_altered_response_of	0.96612996
66	MP0002254_reproductive_system_inflammat	0.96284112
67	MP0005360_urolithiasis	0.93652558
68	MP0005636_abnormal_mineral_homeostasis	0.92758499
69	MP0005551_abnormal_eye_electrophysiolog	0.91768974
70	MP0001485_abnormal_pinna_reflex	0.90910257
71	MP0002751_abnormal_autonomic_nervous	0.89891518
72	MP0005075_abnormal_melanosome_morpholog	0.85987062
73	MP0002067_abnormal_sensory_capabilities	0.85759846
74	MP0000631_abnormal_neuroendocrine_gland	0.85565926
75	MP0001986_abnormal_taste_sensitivity	0.85166059
76	MP0002269_muscular_atrophy	0.84768572
77	MP0002822_catalepsy	0.84726789
78	MP0001764_abnormal_homeostasis	0.84512768
79	MP0005330_cardiomyopathy	0.84274279
80	MP0009745_abnormal_behavioral_response	0.83547379
81	MP0001293_anophthalmia	0.82284016
82	MP0004742_abnormal_vestibular_system	0.81130131
83	MP0002090_abnormal_vision	0.80993000
84	MP0000516_abnormal_urinary_system	0.78273600
85	MP0005367_renal/urinary_system_phenotyp	0.78273600
86	MP0002638_abnormal_pupillary_reflex	0.78268202
87	MP0000015_abnormal_ear_pigmentation	0.78211440
88	MP0002272_abnormal_nervous_system	0.76051308
89	MP0003136_yellow_coat_color	0.74995143
90	MP0001905_abnormal_dopamine_level	0.74580021
91	MP0005379_endocrine/exocrine_gland_phen	0.74536346
92	MP0004270_analgesia	0.74258237
93	MP0001968_abnormal_touch/_nociception	0.74247916
94	MP0003122_maternal_imprinting	0.73822404
95	MP0002735_abnormal_chemical_nociception	0.72856332
96	MP0002161_abnormal_fertility/fecundity	0.69610011
97	MP0001486_abnormal_startle_reflex	0.69606543
98	MP0001119_abnormal_female_reproductive	0.69462252
99	MP0002734_abnormal_mechanical_nocicepti	0.69456563
100	MP0000647_abnormal_sebaceous_gland	0.69135753

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.60383777
2	Lipid accumulation in hepatocytes (HP:0006561)	4.30850457
3	Abnormal gallbladder physiology (HP:0012438)	3.60092585
4	Cholecystitis (HP:0001082)	3.60092585
5	Renal Fanconi syndrome (HP:0001994)	3.54812430
6	Entropion (HP:0000621)	3.40737117
7	Increased CSF lactate (HP:0002490)	3.27874844
8	Mitochondrial inheritance (HP:0001427)	3.21371744
9	CNS hypomyelination (HP:0003429)	3.18726242
10	Acute necrotizing encephalopathy (HP:0006965)	3.11757855
11	Exertional dyspnea (HP:0002875)	3.06651836
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.02662907
13	Acute encephalopathy (HP:0006846)	2.92169737
14	Increased intramyocellular lipid droplets (HP:0012240)	2.91824616
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86049570
16	Methylmalonic acidemia (HP:0002912)	2.85944431
17	Renal cortical cysts (HP:0000803)	2.84936425
18	Increased serum pyruvate (HP:0003542)	2.79225001
19	Homocystinuria (HP:0002156)	2.77809793
20	Abnormality of homocysteine metabolism (HP:0010919)	2.77809793
21	Abnormality of the labia minora (HP:0012880)	2.77091654
22	Submucous cleft hard palate (HP:0000176)	2.72999624
23	Progressive macrocephaly (HP:0004481)	2.70451016
24	Pancreatic fibrosis (HP:0100732)	2.70365275
25	Abnormality of the renal cortex (HP:0011035)	2.66555631
26	Molar tooth sign on MRI (HP:0002419)	2.63974767
27	Abnormality of midbrain morphology (HP:0002418)	2.63974767
28	Abnormality of urine glucose concentration (HP:0011016)	2.59899592
29	Glycosuria (HP:0003076)	2.59899592
30	Hepatic necrosis (HP:0002605)	2.58550736
31	Amniotic constriction ring (HP:0009775)	2.56004218
32	Abnormality of placental membranes (HP:0011409)	2.56004218
33	Hepatocellular necrosis (HP:0001404)	2.52498137
34	Abnormality of glycolysis (HP:0004366)	2.51955795
35	Abnormal glycosylation (HP:0012345)	2.51642383
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.51642383
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.51642383
38	Abnormal protein glycosylation (HP:0012346)	2.51642383
39	Type I transferrin isoform profile (HP:0003642)	2.51490761
40	Truncus arteriosus (HP:0001660)	2.47580787
41	Pancreatic cysts (HP:0001737)	2.47004414
42	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.46377810
43	Increased muscle lipid content (HP:0009058)	2.45921639
44	Increased serum lactate (HP:0002151)	2.42978798
45	Upper limb muscle weakness (HP:0003484)	2.42648583
46	Type II lissencephaly (HP:0007260)	2.37332017
47	Retinal dysplasia (HP:0007973)	2.35100126
48	Congenital, generalized hypertrichosis (HP:0004540)	2.31861382
49	Hypoplasia of the uterus (HP:0000013)	2.28561508
50	Methylmalonic aciduria (HP:0012120)	2.26012568
51	Respiratory difficulties (HP:0002880)	2.26007542
52	Reticulocytosis (HP:0001923)	2.21665062
53	Stomatitis (HP:0010280)	2.20529986
54	Poor suck (HP:0002033)	2.19755722
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.18940870
56	Hyperthyroidism (HP:0000836)	2.18802282
57	Abnormality of renal resorption (HP:0011038)	2.17958206
58	Nephronophthisis (HP:0000090)	2.17432280
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.16120854
60	Chronic hepatic failure (HP:0100626)	2.14395753
61	Hyperglycinemia (HP:0002154)	2.14132351
62	Hyperphosphaturia (HP:0003109)	2.12757242
63	Abnormality of DNA repair (HP:0003254)	2.10615944
64	True hermaphroditism (HP:0010459)	2.08810353
65	Sclerocornea (HP:0000647)	2.08298889
66	Medial flaring of the eyebrow (HP:0010747)	2.05291647
67	Type 2 muscle fiber atrophy (HP:0003554)	2.03631876
68	Lactic acidosis (HP:0003128)	2.02228804
69	Adrenal hypoplasia (HP:0000835)	2.00224700
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96770772
71	Cerebral hypomyelination (HP:0006808)	1.96764802
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94260437
73	Meckel diverticulum (HP:0002245)	1.91369824
74	Abnormality of methionine metabolism (HP:0010901)	1.89619849
75	Abnormal hemoglobin (HP:0011902)	1.89562774
76	Abnormality of the ileum (HP:0001549)	1.88059731
77	Exercise intolerance (HP:0003546)	1.87973804
78	Muscle fiber atrophy (HP:0100295)	1.86603157
79	Tachypnea (HP:0002789)	1.86466996
80	Generalized aminoaciduria (HP:0002909)	1.86094774
81	Chromsome breakage (HP:0040012)	1.83122693
82	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82767161
83	Hypoplasia of the fovea (HP:0007750)	1.82767161
84	Azoospermia (HP:0000027)	1.82396733
85	Prominent nasal bridge (HP:0000426)	1.81785673
86	Oculomotor apraxia (HP:0000657)	1.81057607
87	Tubular atrophy (HP:0000092)	1.80600970
88	Lethargy (HP:0001254)	1.80457388
89	Limb dystonia (HP:0002451)	1.79985815
90	Optic disc pallor (HP:0000543)	1.78782908
91	Cerebral edema (HP:0002181)	1.77330553
92	Spastic paraparesis (HP:0002313)	1.76391808
93	Abnormal number of erythroid precursors (HP:0012131)	1.75112649
94	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.74266616
95	Aganglionic megacolon (HP:0002251)	1.73529826
96	Abnormality of reticulocytes (HP:0004312)	1.73329831
97	Aplastic anemia (HP:0001915)	1.72297845
98	Gait imbalance (HP:0002141)	1.70847569
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70658987
100	Congenital primary aphakia (HP:0007707)	1.69958048

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	5.61182507
2	EIF2AK3	3.73537247
3	BUB1	3.31372494
4	TRIM28	2.89330699
5	NEK1	2.81474504
6	SRPK1	2.78234324
7	PINK1	2.73627526
8	NUAK1	2.50686531
9	PNCK	2.50006637
10	ZAK	2.46823642
11	MAP4K2	2.40713442
12	NME1	2.30196207
13	MST4	2.13418366
14	PLK2	1.92749697
15	TTK	1.84167676
16	SIK3	1.75308865
17	PLK3	1.70955911
18	MAP3K4	1.65080843
19	BCR	1.61892043
20	CLK1	1.59118836
21	NTRK3	1.41661222
22	PLK4	1.41052846
23	MAPK13	1.38934584
24	FRK	1.34499998
25	TSSK6	1.32859561
26	ADRBK2	1.29640311
27	RAF1	1.26987682
28	PBK	1.26193548
29	DYRK2	1.25544665
30	NEK2	1.24981635
31	BCKDK	1.24257732
32	WEE1	1.16632444
33	TNIK	1.10667162
34	EPHA3	1.06866202
35	GRK1	1.05878385
36	PDK2	1.05622919
37	STK16	1.05569546
38	DAPK2	1.04457540
39	RPS6KA4	0.96312046
40	FLT3	0.92768857
41	PLK1	0.92174774
42	WNK4	0.89894425
43	TLK1	0.89213078
44	PKN2	0.88832516
45	MAP3K9	0.86859139
46	NME2	0.85674958
47	CSNK1G3	0.82761684
48	CSNK1A1L	0.77546068
49	PHKG2	0.77530791
50	PHKG1	0.77530791
51	MATK	0.77314219
52	MAP2K7	0.77169974
53	TAOK3	0.70993983
54	SCYL2	0.70802862
55	CSNK1G1	0.70716501
56	CSNK1G2	0.69851875
57	VRK1	0.69226677
58	KSR1	0.68216136
59	ILK	0.62400266
60	ATR	0.62018006
61	ERBB3	0.61579308
62	BRSK1	0.59541063
63	BRAF	0.58397410
64	WNK3	0.57933247
65	KSR2	0.54535857
66	MINK1	0.54314243
67	TRPM7	0.53098408
68	TXK	0.52878178
69	CSNK2A2	0.52557882
70	PAK3	0.52198262
71	CSNK1E	0.51747789
72	PTK2B	0.50784649
73	EIF2AK2	0.50192936
74	CHEK2	0.49587291
75	PRKD3	0.47608340
76	CSNK2A1	0.46521074
77	MAPKAPK3	0.46348568
78	STK3	0.44244047
79	MAPKAPK5	0.43517172
80	MAP3K8	0.43458976
81	ATM	0.42861071
82	RPS6KA5	0.42763141
83	BMPR1B	0.42745461
84	ALK	0.42027586
85	CHEK1	0.40488236
86	CAMK1G	0.40255204
87	CAMK2A	0.37590915
88	MARK1	0.34531329
89	DYRK3	0.34509996
90	AURKB	0.33768728
91	AURKA	0.33138243
92	PRKCG	0.33129317
93	PRKCE	0.29655625
94	RPS6KB1	0.27442902
95	MARK3	0.27196980
96	BRSK2	0.26212309
97	DMPK	0.26070087
98	PRKACB	0.26040641
99	CDK8	0.24588440
100	CDK1	0.24420983

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.63461196
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.38085349
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.28603573
4	Parkinsons disease_Homo sapiens_hsa05012	3.02696379
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.68670564
6	RNA polymerase_Homo sapiens_hsa03020	2.66409696
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.60271578
8	Proteasome_Homo sapiens_hsa03050	2.52653193
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.34397279
10	One carbon pool by folate_Homo sapiens_hsa00670	2.20806334
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.13760633
12	Mismatch repair_Homo sapiens_hsa03430	2.13067014
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11274599
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.09931441
15	RNA transport_Homo sapiens_hsa03013	1.99756358
16	Huntingtons disease_Homo sapiens_hsa05016	1.99539830
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.93040868
18	DNA replication_Homo sapiens_hsa03030	1.87486450
19	RNA degradation_Homo sapiens_hsa03018	1.86989306
20	Base excision repair_Homo sapiens_hsa03410	1.83584393
21	Sulfur relay system_Homo sapiens_hsa04122	1.79859736
22	Spliceosome_Homo sapiens_hsa03040	1.79825882
23	Propanoate metabolism_Homo sapiens_hsa00640	1.78923103
24	Alzheimers disease_Homo sapiens_hsa05010	1.75182578
25	Fatty acid elongation_Homo sapiens_hsa00062	1.73244757
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.68123756
27	Homologous recombination_Homo sapiens_hsa03440	1.65285724
28	Ribosome_Homo sapiens_hsa03010	1.64285373
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.63960687
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.63701305
31	Basal transcription factors_Homo sapiens_hsa03022	1.63235903
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52072785
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51685894
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44798305
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44327924
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.39210043
37	Purine metabolism_Homo sapiens_hsa00230	1.38044354
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.28308898
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.27671188
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26959086
41	Oocyte meiosis_Homo sapiens_hsa04114	1.26305440
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.25872619
43	Butanoate metabolism_Homo sapiens_hsa00650	1.25587306
44	Glutathione metabolism_Homo sapiens_hsa00480	1.22874489
45	Sulfur metabolism_Homo sapiens_hsa00920	1.19834747
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10522748
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.07207871
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.03527411
49	Cell cycle_Homo sapiens_hsa04110	1.02797095
50	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96899738
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93826296
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89233794
53	Regulation of autophagy_Homo sapiens_hsa04140	0.86922208
54	Metabolic pathways_Homo sapiens_hsa01100	0.86673762
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.86047597
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.82297281
57	Peroxisome_Homo sapiens_hsa04146	0.79578018
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.75696463
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75439581
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74479705
61	Nicotine addiction_Homo sapiens_hsa05033	0.71307501
62	Phototransduction_Homo sapiens_hsa04744	0.69995324
63	Folate biosynthesis_Homo sapiens_hsa00790	0.64750016
64	Carbon metabolism_Homo sapiens_hsa01200	0.62210866
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61748277
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59758812
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57530643
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56476934
69	p53 signaling pathway_Homo sapiens_hsa04115	0.56224955
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.54496639
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52604014
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51913579
73	GABAergic synapse_Homo sapiens_hsa04727	0.49578751
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47580139
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44688647
76	Olfactory transduction_Homo sapiens_hsa04740	0.43295092
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.43160887
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43065678
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40392081
80	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37259098
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.37181198
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37037964
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33047174
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31497061
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28930073
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27258671
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.26853165
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26364901
89	Fatty acid degradation_Homo sapiens_hsa00071	0.25304344
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23008803
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.21380164
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.20585478
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.20257093
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.18171663
95	Malaria_Homo sapiens_hsa05144	0.17901800
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.17412558
97	Morphine addiction_Homo sapiens_hsa05032	0.16084552
98	Taste transduction_Homo sapiens_hsa04742	0.15679279
99	Mineral absorption_Homo sapiens_hsa04978	0.13935253
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.12853145

RPL23AP21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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