RPL23AP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of regulatory T cell differentiation (GO:0045589)5.48016139
2response to pheromone (GO:0019236)5.31280613
3regulation of isotype switching to IgG isotypes (GO:0048302)4.65474497
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.55720615
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.55720615
6modulation by symbiont of host immune response (GO:0052553)4.55720615
7positive regulation by symbiont of host defense response (GO:0052509)4.55720615
8modulation by symbiont of host defense response (GO:0052031)4.55720615
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.55720615
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.52300929
11detection of molecule of bacterial origin (GO:0032490)4.49530022
12negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.44847564
13positive regulation of toll-like receptor signaling pathway (GO:0034123)4.35656819
14positive regulation of interleukin-17 production (GO:0032740)4.22477580
15positive regulation of gamma-delta T cell activation (GO:0046645)4.10356413
16microglial cell activation (GO:0001774)4.07338226
17regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.99554469
18prenylation (GO:0097354)3.91674830
19protein prenylation (GO:0018342)3.91674830
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.89417601
21regulation of translation, ncRNA-mediated (GO:0045974)3.89417601
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89417601
23cellular response to interleukin-15 (GO:0071350)3.87913836
24negative regulation of T cell mediated immunity (GO:0002710)3.51812186
25regulation of interleukin-17 production (GO:0032660)3.50322330
26protein K11-linked deubiquitination (GO:0035871)3.47238147
27regulation of B cell receptor signaling pathway (GO:0050855)3.35945817
28regulation of immunoglobulin secretion (GO:0051023)3.32790512
29N-terminal protein amino acid acetylation (GO:0006474)3.30674992
30regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.30534241
31embryonic hemopoiesis (GO:0035162)3.30206710
32regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.27150529
33positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.27150529
34male sex determination (GO:0030238)3.23060793
35interferon-gamma production (GO:0032609)3.22459853
36positive regulation of granulocyte differentiation (GO:0030854)3.22442626
37regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.21679477
38positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.21679477
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19517545
40positive regulation of mRNA processing (GO:0050685)3.19010874
41response to host immune response (GO:0052572)3.18829331
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18829331
43response to interleukin-15 (GO:0070672)3.16845689
44regulation of gamma-delta T cell activation (GO:0046643)3.13105037
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11865020
46T cell migration (GO:0072678)3.11647906
47tolerance induction (GO:0002507)3.09037208
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.05717128
49neural tube formation (GO:0001841)3.05364894
50negative T cell selection (GO:0043383)3.03392979
51positive regulation of DNA recombination (GO:0045911)3.03161580
52T-helper cell differentiation (GO:0042093)3.02723403
53CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.02723403
54positive regulation of mRNA metabolic process (GO:1903313)3.02454855
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02296329
56negative regulation of T-helper cell differentiation (GO:0045623)3.02296329
57negative thymic T cell selection (GO:0045060)3.00388799
58positive regulation of isotype switching (GO:0045830)2.99994866
59positive regulation of insulin receptor signaling pathway (GO:0046628)2.99408003
60positive regulation of mRNA catabolic process (GO:0061014)2.96282854
61negative regulation of interleukin-12 production (GO:0032695)2.95160177
62negative regulation of mast cell activation (GO:0033004)2.92611201
63cellular response to ethanol (GO:0071361)2.89719708
64regulation of memory T cell differentiation (GO:0043380)2.87513314
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87364193
66protein K63-linked deubiquitination (GO:0070536)2.86986035
67histone H3-K9 modification (GO:0061647)2.86967972
68negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.86398313
69interkinetic nuclear migration (GO:0022027)2.85466662
70fibroblast migration (GO:0010761)2.84273618
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84198412
72face development (GO:0060324)2.83702624
73response to host (GO:0075136)2.83326883
74response to host defenses (GO:0052200)2.83326883
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83326883
76CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.78908017
77hepatocyte apoptotic process (GO:0097284)2.77778295
78negative regulation of interleukin-17 production (GO:0032700)2.75919964
79L-fucose catabolic process (GO:0042355)2.74762175
80fucose catabolic process (GO:0019317)2.74762175
81L-fucose metabolic process (GO:0042354)2.74762175
82negative regulation of cell killing (GO:0031342)2.74309423
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74309423
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73804144
85protein K48-linked deubiquitination (GO:0071108)2.72154775
86RNA destabilization (GO:0050779)2.71629913
87macrophage activation involved in immune response (GO:0002281)2.71540983
88negative regulation of B cell apoptotic process (GO:0002903)2.65891520
89pericardium development (GO:0060039)2.63953108
90pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.63313481
91UMP biosynthetic process (GO:0006222)2.63313481
92pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.63313481
93UMP metabolic process (GO:0046049)2.63313481
94macrophage activation (GO:0042116)2.62877198
95positive regulation of interleukin-12 production (GO:0032735)2.62145371
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.60082074
97positive regulation of B cell mediated immunity (GO:0002714)2.60082074
98T cell differentiation involved in immune response (GO:0002292)2.59866311
99alpha-beta T cell differentiation involved in immune response (GO:0002293)2.59866311
100alpha-beta T cell activation involved in immune response (GO:0002287)2.59866311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82519405
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51342190
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04756483
4GBX2_23144817_ChIP-Seq_PC3_Human2.96625106
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.85255111
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74212396
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51480079
8TAF15_26573619_Chip-Seq_HEK293_Human2.48849615
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38634339
10RUNX_20019798_ChIP-Seq_JUKART_Human2.26775935
11EWS_26573619_Chip-Seq_HEK293_Human2.26065100
12IRF1_19129219_ChIP-ChIP_H3396_Human2.20761589
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03092262
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90713821
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.90453888
16ZNF274_21170338_ChIP-Seq_K562_Hela1.88897296
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79597240
18P300_19829295_ChIP-Seq_ESCs_Human1.79258952
19VDR_22108803_ChIP-Seq_LS180_Human1.78325180
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.74467110
21TP53_16413492_ChIP-PET_HCT116_Human1.73808567
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.72540301
23ER_23166858_ChIP-Seq_MCF-7_Human1.72458233
24AR_21572438_ChIP-Seq_LNCaP_Human1.70925952
25MYB_26560356_Chip-Seq_TH2_Human1.69555035
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69318728
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66277551
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63410094
29IGF1R_20145208_ChIP-Seq_DFB_Human1.63351272
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54275141
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53881410
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50595931
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48421713
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45873567
35GATA3_26560356_Chip-Seq_TH2_Human1.45497509
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45393816
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44540998
38STAT3_23295773_ChIP-Seq_U87_Human1.44357237
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.42685313
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40003383
41SMAD4_21799915_ChIP-Seq_A2780_Human1.39331986
42CBP_20019798_ChIP-Seq_JUKART_Human1.38779061
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38779061
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37736491
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37037435
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.35696936
47BCAT_22108803_ChIP-Seq_LS180_Human1.34684016
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.34340632
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34127139
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33939273
51GATA3_27048872_Chip-Seq_THYMUS_Human1.32399176
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31000551
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30723152
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30140598
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29379950
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29295534
57FUS_26573619_Chip-Seq_HEK293_Human1.28228425
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26955789
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25633047
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25249261
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.25053078
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24883268
63VDR_24787735_ChIP-Seq_THP-1_Human1.22944752
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.22620548
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21977204
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19662133
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18490030
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.17995917
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17931252
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17576711
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.15241301
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.14477083
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13097498
74CDX2_22108803_ChIP-Seq_LS180_Human1.12276727
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11800086
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10058765
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.09209116
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08850867
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.08741386
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08712689
81P53_22387025_ChIP-Seq_ESCs_Mouse1.07993275
82TP53_18474530_ChIP-ChIP_U2OS_Human1.07209701
83MYB_26560356_Chip-Seq_TH1_Human1.06936747
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06563537
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06290017
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04467888
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02684310
88TCF4_23295773_ChIP-Seq_U87_Human1.02668639
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02641150
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00650870
91KDM2B_26808549_Chip-Seq_REH_Human0.98503855
92CMYC_18555785_Chip-Seq_ESCs_Mouse0.98228290
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.97759287
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.97427910
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96604137
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.96508760
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96399270
98RUNX2_22187159_ChIP-Seq_PCA_Human0.95683656
99SOX2_19829295_ChIP-Seq_ESCs_Human0.94113880
100NANOG_19829295_ChIP-Seq_ESCs_Human0.94113880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.34073789
2MP0008057_abnormal_DNA_replication5.01747977
3MP0003724_increased_susceptibility_to4.38769575
4MP0003183_abnormal_peptide_metabolism4.17467764
5MP0001835_abnormal_antigen_presentation3.34348398
6MP0000465_gastrointestinal_hemorrhage3.11649786
7MP0002822_catalepsy2.63264627
8MP0002009_preneoplasia2.54170211
9MP0001853_heart_inflammation2.53865798
10MP0003763_abnormal_thymus_physiology2.40326978
11MP0004381_abnormal_hair_follicle2.34671378
12MP0003300_gastrointestinal_ulcer2.34532370
13MP0008260_abnormal_autophagy2.33440953
14MP0008877_abnormal_DNA_methylation2.11093679
15MP0006054_spinal_hemorrhage2.06235410
16MP0000015_abnormal_ear_pigmentation2.05300031
17MP0002163_abnormal_gland_morphology2.03807256
18MP0001800_abnormal_humoral_immune1.98314185
19MP0000685_abnormal_immune_system1.96947196
20MP0003436_decreased_susceptibility_to1.91658679
21MP0005671_abnormal_response_to1.86617173
22MP0002405_respiratory_system_inflammati1.85682172
23MP0003828_pulmonary_edema1.84888315
24MP0005174_abnormal_tail_pigmentation1.81852458
25MP0005083_abnormal_biliary_tract1.81027622
26MP0000604_amyloidosis1.67359105
27MP0005000_abnormal_immune_tolerance1.67268094
28MP0001790_abnormal_immune_system1.67216119
29MP0005387_immune_system_phenotype1.67216119
30MP0003656_abnormal_erythrocyte_physiolo1.60004186
31MP0000427_abnormal_hair_cycle1.55029896
32MP0002166_altered_tumor_susceptibility1.53038894
33MP0002933_joint_inflammation1.51485693
34MP0004742_abnormal_vestibular_system1.49379564
35MP0002723_abnormal_immune_serum1.49194125
36MP0002452_abnormal_antigen_presenting1.43048535
37MP0002420_abnormal_adaptive_immunity1.40629469
38MP0002398_abnormal_bone_marrow1.39103430
39MP0001819_abnormal_immune_cell1.38464149
40MP0002234_abnormal_pharynx_morphology1.35742941
41MP0000516_abnormal_urinary_system1.34466081
42MP0005367_renal/urinary_system_phenotyp1.34466081
43MP0002722_abnormal_immune_system1.31719587
44MP0000689_abnormal_spleen_morphology1.27311374
45MP0000703_abnormal_thymus_morphology1.27077037
46MP0009764_decreased_sensitivity_to1.24677550
47MP0009785_altered_susceptibility_to1.23210266
48MP0002148_abnormal_hypersensitivity_rea1.19142839
49MP0002751_abnormal_autonomic_nervous1.17766610
50MP0000383_abnormal_hair_follicle1.16773009
51MP0002419_abnormal_innate_immunity1.14089558
52MP0000716_abnormal_immune_system1.13960851
53MP0004883_abnormal_blood_vessel1.13052567
54MP0002006_tumorigenesis1.12275669
55MP0002332_abnormal_exercise_endurance1.09180289
56MP0005025_abnormal_response_to1.08603007
57MP0004484_altered_response_of1.04157978
58MP0006292_abnormal_olfactory_placode1.04001908
59MP0003787_abnormal_imprinting1.03456571
60MP0004885_abnormal_endolymph1.00673301
61MP0002928_abnormal_bile_duct1.00045235
62MP0005075_abnormal_melanosome_morpholog0.99255761
63MP0001968_abnormal_touch/_nociception0.98887043
64MP0008872_abnormal_physiological_respon0.97000521
65MP0001533_abnormal_skeleton_physiology0.96959563
66MP0005379_endocrine/exocrine_gland_phen0.92789588
67MP0001879_abnormal_lymphatic_vessel0.91701042
68MP0002138_abnormal_hepatobiliary_system0.91477964
69MP0003195_calcinosis0.91265606
70MP0005164_abnormal_response_to0.90621404
71MP0002736_abnormal_nociception_after0.89351366
72MP0001845_abnormal_inflammatory_respons0.89312722
73MP0002095_abnormal_skin_pigmentation0.87971784
74MP0009278_abnormal_bone_marrow0.87296666
75MP0002429_abnormal_blood_cell0.85238553
76MP0002971_abnormal_brown_adipose0.84223808
77MP0000858_altered_metastatic_potential0.80963078
78MP0008775_abnormal_heart_ventricle0.78598105
79MP0010155_abnormal_intestine_physiology0.77378571
80MP0003221_abnormal_cardiomyocyte_apopto0.76456553
81MP0009115_abnormal_fat_cell0.75737563
82MP0005389_reproductive_system_phenotype0.75694759
83MP0003646_muscle_fatigue0.74572036
84MP0003866_abnormal_defecation0.74441332
85MP0000613_abnormal_salivary_gland0.73900894
86MP0000647_abnormal_sebaceous_gland0.73514156
87MP0001501_abnormal_sleep_pattern0.73106615
88MP0004947_skin_inflammation0.72247826
89MP0005388_respiratory_system_phenotype0.71017511
90MP0002133_abnormal_respiratory_system0.71017511
91MP0008995_early_reproductive_senescence0.70081842
92MP0001502_abnormal_circadian_rhythm0.68497581
93MP0003786_premature_aging0.68430556
94MP0000249_abnormal_blood_vessel0.61761681
95MP0005266_abnormal_metabolism0.61457382
96MP0001919_abnormal_reproductive_system0.60820796
97MP0004130_abnormal_muscle_cell0.60455940
98MP0005310_abnormal_salivary_gland0.60066942
99MP0010307_abnormal_tumor_latency0.58177376
100MP0000631_abnormal_neuroendocrine_gland0.57916458

Predicted human phenotypes

RankGene SetZ-score
1Fair hair (HP:0002286)4.54446566
2Stomatitis (HP:0010280)4.06046784
3T lymphocytopenia (HP:0005403)4.00302967
4Tented upper lip vermilion (HP:0010804)3.64389594
5Generalized hypopigmentation of hair (HP:0011358)3.64186524
6Abnormality of T cell number (HP:0011839)3.57413456
7Papilledema (HP:0001085)3.42057284
8Clumsiness (HP:0002312)3.35647084
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34802715
10Retrobulbar optic neuritis (HP:0100654)3.32199207
11Optic neuritis (HP:0100653)3.32199207
12IgG deficiency (HP:0004315)3.20641160
13Diastasis recti (HP:0001540)3.14730513
14Renal cortical cysts (HP:0000803)2.96485240
15Recurrent fungal infections (HP:0002841)2.89300532
16Protruding tongue (HP:0010808)2.86738094
17Abnormality of the renal cortex (HP:0011035)2.83943421
18Elevated erythrocyte sedimentation rate (HP:0003565)2.83433312
19Stomach cancer (HP:0012126)2.80450073
20Recurrent bronchitis (HP:0002837)2.78276198
21Eczematoid dermatitis (HP:0000976)2.76505835
22Thyroiditis (HP:0100646)2.74900100
23Thyroid-stimulating hormone excess (HP:0002925)2.73292234
24Absent speech (HP:0001344)2.70958715
25Genetic anticipation (HP:0003743)2.67821482
26Myositis (HP:0100614)2.62540244
27Severe combined immunodeficiency (HP:0004430)2.59733487
28Abnormal rod and cone electroretinograms (HP:0008323)2.58621181
29Abnormality of incisor morphology (HP:0011063)2.58407895
30Congenital, generalized hypertrichosis (HP:0004540)2.56777145
31Carpal bone hypoplasia (HP:0001498)2.56293709
32Orchitis (HP:0100796)2.56056008
33Attenuation of retinal blood vessels (HP:0007843)2.54237733
34Constricted visual fields (HP:0001133)2.52421271
35Thoracolumbar scoliosis (HP:0002944)2.48707001
36Conical tooth (HP:0000698)2.46532965
37Eosinophilia (HP:0001880)2.46314540
38True hermaphroditism (HP:0010459)2.43325412
39B lymphocytopenia (HP:0010976)2.42877473
40Small hand (HP:0200055)2.34950250
41Abnormality of T cells (HP:0002843)2.34070976
42Increased IgM level (HP:0003496)2.30913866
43Abnormality of eosinophils (HP:0001879)2.30794423
44Febrile seizures (HP:0002373)2.26508333
45Broad ribs (HP:0000885)2.24858180
46Vertebral arch anomaly (HP:0008438)2.23559489
47Abnormality of B cell number (HP:0010975)2.22974346
48Keratoconjunctivitis (HP:0001096)2.22146137
49Abnormality of alanine metabolism (HP:0010916)2.21768071
50Hyperalaninemia (HP:0003348)2.21768071
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21768071
52Broad-based gait (HP:0002136)2.11549448
53Keratoconjunctivitis sicca (HP:0001097)2.11321105
54Pancreatic cysts (HP:0001737)2.11126047
55Chronic diarrhea (HP:0002028)2.10550637
56Macroglossia (HP:0000158)2.08077922
57Hyperventilation (HP:0002883)2.06628375
58Congenital stationary night blindness (HP:0007642)2.06580533
59IgA deficiency (HP:0002720)2.04922121
60Thickened calvaria (HP:0002684)2.03835600
61Decreased central vision (HP:0007663)2.02819291
62Gaze-evoked nystagmus (HP:0000640)2.00846700
63Leukocytosis (HP:0001974)2.00843554
64Panhypogammaglobulinemia (HP:0003139)2.00248615
65Bony spicule pigmentary retinopathy (HP:0007737)1.97202913
66Spontaneous hematomas (HP:0007420)1.96955421
67Nonprogressive disorder (HP:0003680)1.96322788
68Encephalitis (HP:0002383)1.95901381
69Abnormality of pyrimidine metabolism (HP:0004353)1.95789476
70Recurrent cutaneous fungal infections (HP:0011370)1.95731494
71Chronic mucocutaneous candidiasis (HP:0002728)1.95731494
72Hypoplastic iliac wings (HP:0002866)1.90804059
73Abnormality of secondary sexual hair (HP:0009888)1.90173141
74Abnormality of the axillary hair (HP:0100134)1.90173141
75Albinism (HP:0001022)1.88388761
76Combined immunodeficiency (HP:0005387)1.87608218
77Flat occiput (HP:0005469)1.87522568
78Progressive cerebellar ataxia (HP:0002073)1.84081132
79Hemoptysis (HP:0002105)1.83544683
80Widely spaced teeth (HP:0000687)1.82154231
81Anomalous pulmonary venous return (HP:0010772)1.82013107
82Pancreatic fibrosis (HP:0100732)1.79284202
83Abnormality of DNA repair (HP:0003254)1.77204658
84Hematochezia (HP:0002573)1.76225260
85Clitoromegaly (HP:0000057)1.75706981
86Muscle fibrillation (HP:0010546)1.75518812
87Recurrent viral infections (HP:0004429)1.73956083
88Ectopic kidney (HP:0000086)1.72875301
89Hemiplegia (HP:0002301)1.71104626
90Medulloblastoma (HP:0002885)1.70557661
91Abnormality of chromosome stability (HP:0003220)1.70349079
92Poikilocytosis (HP:0004447)1.68282049
93Blue irides (HP:0000635)1.68217334
94Prolonged bleeding time (HP:0003010)1.67556553
95Arterial thrombosis (HP:0004420)1.66327575
96Cupped ear (HP:0000378)1.65007575
97Broad alveolar ridges (HP:0000187)1.64043295
98Clubbing of toes (HP:0100760)1.63883361
99Dyschromatopsia (HP:0007641)1.63822751
100Bronchitis (HP:0012387)1.63536932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.24006173
2FRK3.77541830
3BRD43.61602574
4BMPR1B3.28897379
5ACVR1B3.05041719
6IRAK12.42391744
7NLK2.37637212
8TAOK32.37612324
9TNIK2.29510890
10TXK2.26754089
11BLK2.15227770
12MAP4K12.09540977
13GRK62.08341766
14MKNK21.79624858
15IRAK41.71975463
16ZAP701.71949806
17MAP3K141.60195909
18EPHA31.46253691
19MELK1.45455779
20TEC1.39268982
21IKBKE1.35447974
22TLK11.25289660
23SGK21.22254181
24JAK11.18671754
25OXSR11.10193778
26SYK1.07135797
27IKBKB1.06175611
28TGFBR11.05937558
29IRAK21.04278526
30CAMKK21.03929199
31ADRBK21.03911638
32AKT31.02499820
33NUAK11.00805500
34BTK0.99470588
35ZAK0.98145341
36CSK0.94414758
37PTK2B0.93827825
38EPHB10.93469243
39MKNK10.92724780
40LATS10.89719425
41FES0.89370754
42DYRK30.86807579
43RPS6KA40.85231844
44MAP4K20.84662080
45BRSK20.84480009
46PINK10.83770659
47MAP2K30.82573131
48CHUK0.81782776
49FGFR20.81634624
50ADRBK10.80754290
51PAK30.79944433
52HIPK20.76618471
53PIM10.76009384
54MAP2K20.75435405
55STK380.69808451
56SGK4940.69291727
57SGK2230.69291727
58GRK10.68096381
59HCK0.67604263
60WNK30.65269302
61ITK0.64307204
62SGK30.60945273
63NEK90.60873536
64PIK3CA0.60605717
65CSF1R0.58879681
66LYN0.58600126
67MAP3K30.56857366
68NEK60.55668833
69RPS6KA50.55085782
70FGFR30.53660019
71TRPM70.52899942
72PRKCE0.51965135
73EPHA40.47403858
74MATK0.47020889
75CDK80.46839610
76STK390.45789171
77DYRK1A0.44805746
78FGR0.44512598
79JAK20.44001759
80STK40.43761317
81CAMK40.41546041
82MARK30.41441322
83MAP3K50.39385708
84FER0.39035332
85LCK0.38881578
86STK110.37646647
87MAP3K20.37332215
88CDK40.37176465
89TIE10.35159891
90ERBB30.34131263
91SCYL20.32701220
92TAOK10.31787054
93MAPKAPK20.29524550
94PRKG10.28155153
95ERBB20.28015700
96PIK3CG0.27474502
97TBK10.27414225
98PRKCQ0.27175799
99MAP2K10.24613567
100CDK60.24348719

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046602.72666990
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68218664
3Primary immunodeficiency_Homo sapiens_hsa053402.64187370
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.40800582
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.24663004
6Jak-STAT signaling pathway_Homo sapiens_hsa046302.05604716
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90234039
8Hematopoietic cell lineage_Homo sapiens_hsa046401.89709713
9Graft-versus-host disease_Homo sapiens_hsa053321.86102152
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80001329
11Allograft rejection_Homo sapiens_hsa053301.79884000
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77137326
13Dorso-ventral axis formation_Homo sapiens_hsa043201.70250788
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68534070
15Autoimmune thyroid disease_Homo sapiens_hsa053201.63843656
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63588268
17TNF signaling pathway_Homo sapiens_hsa046681.55713679
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52765413
19Asthma_Homo sapiens_hsa053101.48371201
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46710825
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45408349
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43067622
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34893953
24Measles_Homo sapiens_hsa051621.31975701
25Fanconi anemia pathway_Homo sapiens_hsa034601.30079147
26B cell receptor signaling pathway_Homo sapiens_hsa046621.26984492
27Leishmaniasis_Homo sapiens_hsa051401.26535319
28Osteoclast differentiation_Homo sapiens_hsa043801.25074358
29Malaria_Homo sapiens_hsa051441.21844150
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18324403
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17675737
32Basal transcription factors_Homo sapiens_hsa030221.17288649
33Platelet activation_Homo sapiens_hsa046111.13027107
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10572850
35FoxO signaling pathway_Homo sapiens_hsa040681.08435408
36Linoleic acid metabolism_Homo sapiens_hsa005911.07681742
37Type I diabetes mellitus_Homo sapiens_hsa049401.03081525
38Legionellosis_Homo sapiens_hsa051341.00500575
39Prostate cancer_Homo sapiens_hsa052150.98556830
40Salivary secretion_Homo sapiens_hsa049700.93773826
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93372516
42Regulation of autophagy_Homo sapiens_hsa041400.90659517
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90308540
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87898883
45Chemokine signaling pathway_Homo sapiens_hsa040620.86763173
46Staphylococcus aureus infection_Homo sapiens_hsa051500.85663838
47Tuberculosis_Homo sapiens_hsa051520.84778257
48Taste transduction_Homo sapiens_hsa047420.84103871
49Nitrogen metabolism_Homo sapiens_hsa009100.83336715
50Circadian rhythm_Homo sapiens_hsa047100.82711257
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82436114
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82160868
53Phototransduction_Homo sapiens_hsa047440.81718417
54Hepatitis B_Homo sapiens_hsa051610.81211178
55Acute myeloid leukemia_Homo sapiens_hsa052210.80480268
56Viral carcinogenesis_Homo sapiens_hsa052030.80439774
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75977363
58Amphetamine addiction_Homo sapiens_hsa050310.69738042
59Prolactin signaling pathway_Homo sapiens_hsa049170.69570531
60Ether lipid metabolism_Homo sapiens_hsa005650.69219950
61Systemic lupus erythematosus_Homo sapiens_hsa053220.69184456
62Antigen processing and presentation_Homo sapiens_hsa046120.67758287
63Non-small cell lung cancer_Homo sapiens_hsa052230.67136358
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66849156
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.65910796
66Caffeine metabolism_Homo sapiens_hsa002320.65249800
67MAPK signaling pathway_Homo sapiens_hsa040100.64380127
68Apoptosis_Homo sapiens_hsa042100.63761419
69RNA degradation_Homo sapiens_hsa030180.63389709
70TGF-beta signaling pathway_Homo sapiens_hsa043500.62902041
71Renin secretion_Homo sapiens_hsa049240.62805136
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60858006
73Rheumatoid arthritis_Homo sapiens_hsa053230.60507646
74Toxoplasmosis_Homo sapiens_hsa051450.60494850
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60175606
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58489549
77Calcium signaling pathway_Homo sapiens_hsa040200.58292309
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57890719
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57654857
80Selenocompound metabolism_Homo sapiens_hsa004500.56413821
81HTLV-I infection_Homo sapiens_hsa051660.55759200
82Inositol phosphate metabolism_Homo sapiens_hsa005620.55734018
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.55247791
84Type II diabetes mellitus_Homo sapiens_hsa049300.54976606
85Ovarian steroidogenesis_Homo sapiens_hsa049130.54647879
86Colorectal cancer_Homo sapiens_hsa052100.51757304
87Olfactory transduction_Homo sapiens_hsa047400.50679200
88Mineral absorption_Homo sapiens_hsa049780.50100431
89cAMP signaling pathway_Homo sapiens_hsa040240.49313094
90Nicotine addiction_Homo sapiens_hsa050330.47447676
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46157532
92Choline metabolism in cancer_Homo sapiens_hsa052310.41732455
93Alcoholism_Homo sapiens_hsa050340.40942716
94MicroRNAs in cancer_Homo sapiens_hsa052060.40266854
95p53 signaling pathway_Homo sapiens_hsa041150.39539285
96Ras signaling pathway_Homo sapiens_hsa040140.39444208
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37092305
98Herpes simplex infection_Homo sapiens_hsa051680.36962157
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36706456
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35939584

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