ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.84641510
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.51747623
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.31819610
4	ATP synthesis coupled proton transport (GO:0015986)	6.31819610
5	ribosomal small subunit assembly (GO:0000028)	4.97298678
6	protein complex biogenesis (GO:0070271)	4.93236380
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.71565816
8	protein localization to microtubule (GO:0035372)	4.70840604
9	mitochondrial respiratory chain complex assembly (GO:0033108)	4.70585558
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.68195049
11	NADH dehydrogenase complex assembly (GO:0010257)	4.68195049
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.68195049
13	signal peptide processing (GO:0006465)	4.59331984
14	electron transport chain (GO:0022900)	4.37575419
15	respiratory electron transport chain (GO:0022904)	4.36337902
16	viral transcription (GO:0019083)	4.17932107
17	translational termination (GO:0006415)	4.17115055
18	chaperone-mediated protein transport (GO:0072321)	4.08498993
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.91123139
20	cotranslational protein targeting to membrane (GO:0006613)	3.90627815
21	protein neddylation (GO:0045116)	3.87230981
22	protein targeting to ER (GO:0045047)	3.86636575
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.76551511
24	protein localization to endoplasmic reticulum (GO:0070972)	3.62911337
25	hydrogen ion transmembrane transport (GO:1902600)	3.62191309
26	protein localization to kinetochore (GO:0034501)	3.58531717
27	protein localization to cytoskeleton (GO:0044380)	3.58363713
28	ATP biosynthetic process (GO:0006754)	3.55045970
29	axonemal dynein complex assembly (GO:0070286)	3.54008587
30	inner mitochondrial membrane organization (GO:0007007)	3.47711544
31	maturation of SSU-rRNA (GO:0030490)	3.46892716
32	regulation of mitochondrial translation (GO:0070129)	3.44584073
33	protein-cofactor linkage (GO:0018065)	3.40274331
34	epithelial cilium movement (GO:0003351)	3.36455166
35	urinary tract smooth muscle contraction (GO:0014848)	3.35805476
36	cellular response to ATP (GO:0071318)	3.32875331
37	ribosomal small subunit biogenesis (GO:0042274)	3.27973943
38	pyrimidine nucleobase catabolic process (GO:0006208)	3.18332148
39	translational elongation (GO:0006414)	3.17186055
40	cellular protein complex disassembly (GO:0043624)	3.14094515
41	proton transport (GO:0015992)	3.12516229
42	protein localization to microtubule cytoskeleton (GO:0072698)	3.11922934
43	attachment of spindle microtubules to kinetochore (GO:0008608)	3.10335130
44	viral life cycle (GO:0019058)	3.09948559
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.09638524
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.08149639
47	axon ensheathment in central nervous system (GO:0032291)	3.06231387
48	central nervous system myelination (GO:0022010)	3.06231387
49	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05137735
50	hydrogen transport (GO:0006818)	3.04982492
51	startle response (GO:0001964)	2.99553278
52	resolution of meiotic recombination intermediates (GO:0000712)	2.95503579
53	sequestering of actin monomers (GO:0042989)	2.89857139
54	pantothenate metabolic process (GO:0015939)	2.89024507
55	translational initiation (GO:0006413)	2.84375962
56	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.80866293
57	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77907051
58	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.77076004
59	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.76292551
60	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.75717548
61	dopamine transport (GO:0015872)	2.75339409
62	cellular component biogenesis (GO:0044085)	2.74574433
63	rRNA modification (GO:0000154)	2.73736994
64	activated T cell proliferation (GO:0050798)	2.72945861
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.67421585
66	translation (GO:0006412)	2.65349407
67	centriole replication (GO:0007099)	2.61564086
68	pseudouridine synthesis (GO:0001522)	2.60773619
69	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.60349432
70	DNA deamination (GO:0045006)	2.58160857
71	protein complex disassembly (GO:0043241)	2.57925518
72	behavioral response to nicotine (GO:0035095)	2.57354895
73	intracellular protein transmembrane import (GO:0044743)	2.54927630
74	platelet dense granule organization (GO:0060155)	2.54324336
75	nucleoside diphosphate catabolic process (GO:0009134)	2.53335549
76	regulation of cilium movement (GO:0003352)	2.53079045
77	nucleobase catabolic process (GO:0046113)	2.52564416
78	cilium movement (GO:0003341)	2.51175212
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.50916329
80	organelle disassembly (GO:1903008)	2.50764081
81	glycerophospholipid catabolic process (GO:0046475)	2.49577757
82	termination of RNA polymerase III transcription (GO:0006386)	2.49389222
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.49389222
84	macromolecular complex disassembly (GO:0032984)	2.48139033
85	glycerol ether metabolic process (GO:0006662)	2.47036680
86	nucleoside triphosphate biosynthetic process (GO:0009142)	2.45852772
87	neuronal action potential propagation (GO:0019227)	2.45620356
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.45128436
89	chromatin remodeling at centromere (GO:0031055)	2.45047731
90	protein K6-linked ubiquitination (GO:0085020)	2.42798384
91	postsynaptic membrane organization (GO:0001941)	2.41551167
92	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.41518819
93	negative regulation of heart rate (GO:0010459)	2.39300380
94	replication fork processing (GO:0031297)	2.38772925
95	ether metabolic process (GO:0018904)	2.37977813
96	rRNA methylation (GO:0031167)	2.36983217
97	protein targeting to membrane (GO:0006612)	2.36370820
98	signal transduction involved in regulation of gene expression (GO:0023019)	2.35383343
99	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.34748977
100	ribosomal large subunit biogenesis (GO:0042273)	2.34729548

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.23649574
2	VDR_22108803_ChIP-Seq_LS180_Human	3.47976476
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.27315782
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.18164350
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.04500592
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01520308
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.80458530
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.77749500
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49904268
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44673109
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.41648027
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38495141
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.35352196
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.25893361
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24664068
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.22196947
17	EWS_26573619_Chip-Seq_HEK293_Human	2.17387446
18	FUS_26573619_Chip-Seq_HEK293_Human	2.16423074
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09632289
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.03970982
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.02660654
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.84426860
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82564074
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80124062
25	P300_19829295_ChIP-Seq_ESCs_Human	1.79500946
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78990874
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78892464
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.70894279
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65037573
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61094792
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.60938750
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58052783
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54999340
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53862560
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49928383
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47585542
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47261101
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.46303679
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46050787
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41888990
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39063198
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.34791502
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33551736
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30257943
45	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27729285
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25871794
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23085857
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23085857
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22920085
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20712499
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20383111
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18425636
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18425636
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18391852
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17367856
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17141649
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16364125
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15192216
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.14919752
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12125691
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12125691
62	AR_25329375_ChIP-Seq_VCAP_Human	1.11933988
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11138646
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11121060
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11070753
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09567172
67	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07709566
68	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04364587
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01224593
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00776787
71	NCOR_22424771_ChIP-Seq_293T_Human	0.99466461
72	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98807999
73	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98275970
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97462192
75	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96234618
76	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96011824
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95614787
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95395718
79	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93946565
80	PHF8_20622853_ChIP-Seq_HELA_Human	0.93675444
81	NFYA_21822215_ChIP-Seq_K562_Human	0.93356123
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93236938
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93095233
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93013692
85	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92657742
86	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92296624
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.92066223
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91966209
89	TBL1_22424771_ChIP-Seq_293T_Human	0.91597373
90	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.89508941
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.88165259
92	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88014752
93	IGF1R_20145208_ChIP-Seq_DFB_Human	0.87961922
94	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.87422512
95	NFYB_21822215_ChIP-Seq_K562_Human	0.87229088
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.86678932
97	JUN_21703547_ChIP-Seq_K562_Human	0.85655016
98	AR_20517297_ChIP-Seq_VCAP_Human	0.85603510
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.84493867
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83621587

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.24305855
2	MP0006292_abnormal_olfactory_placode	3.12641698
3	MP0009379_abnormal_foot_pigmentation	2.94976331
4	MP0003787_abnormal_imprinting	2.74897331
5	MP0004147_increased_porphyrin_level	2.66092895
6	MP0004133_heterotaxia	2.64636546
7	MP0002938_white_spotting	2.52188672
8	MP0004742_abnormal_vestibular_system	2.49348959
9	MP0001529_abnormal_vocalization	2.45784622
10	MP0003123_paternal_imprinting	2.20988673
11	MP0004142_abnormal_muscle_tone	2.20483300
12	MP0002139_abnormal_hepatobiliary_system	2.19864437
13	MP0001968_abnormal_touch/_nociception	2.17344270
14	MP0002736_abnormal_nociception_after	2.10438197
15	MP0000566_synostosis	2.07867601
16	MP0001293_anophthalmia	1.91445864
17	MP0004885_abnormal_endolymph	1.88153313
18	MP0008872_abnormal_physiological_respon	1.83408482
19	MP0003718_maternal_effect	1.80204389
20	MP0001905_abnormal_dopamine_level	1.76224283
21	MP0003136_yellow_coat_color	1.75787975
22	MP0002735_abnormal_chemical_nociception	1.75480437
23	MP0005646_abnormal_pituitary_gland	1.71266939
24	MP0000631_abnormal_neuroendocrine_gland	1.70735851
25	MP0002272_abnormal_nervous_system	1.68694061
26	MP0005084_abnormal_gallbladder_morpholo	1.67614126
27	MP0009745_abnormal_behavioral_response	1.65859433
28	MP0002733_abnormal_thermal_nociception	1.57378045
29	MP0008004_abnormal_stomach_pH	1.56579236
30	MP0002277_abnormal_respiratory_mucosa	1.56341530
31	MP0001485_abnormal_pinna_reflex	1.54776712
32	MP0003121_genomic_imprinting	1.51449344
33	MP0003567_abnormal_fetal_cardiomyocyte	1.51424834
34	MP0006035_abnormal_mitochondrial_morpho	1.47579607
35	MP0002837_dystrophic_cardiac_calcinosis	1.46914979
36	MP0001984_abnormal_olfaction	1.45726371
37	MP0009046_muscle_twitch	1.43821105
38	MP0002064_seizures	1.43408264
39	MP0001440_abnormal_grooming_behavior	1.36851559
40	MP0002067_abnormal_sensory_capabilities	1.34373605
41	MP0002734_abnormal_mechanical_nocicepti	1.33161109
42	MP0001501_abnormal_sleep_pattern	1.26107089
43	MP0003890_abnormal_embryonic-extraembry	1.21191393
44	MP0003646_muscle_fatigue	1.21114755
45	MP0006036_abnormal_mitochondrial_physio	1.19552357
46	MP0001486_abnormal_startle_reflex	1.19292763
47	MP0002572_abnormal_emotion/affect_behav	1.18777873
48	MP0002822_catalepsy	1.18143582
49	MP0001970_abnormal_pain_threshold	1.17742427
50	MP0002102_abnormal_ear_morphology	1.17698449
51	MP0005410_abnormal_fertilization	1.15924774
52	MP0000569_abnormal_digit_pigmentation	1.15483211
53	MP0006276_abnormal_autonomic_nervous	1.14922537
54	MP0006072_abnormal_retinal_apoptosis	1.14896170
55	MP0008058_abnormal_DNA_repair	1.14294514
56	MP0005377_hearing/vestibular/ear_phenot	1.09946930
57	MP0003878_abnormal_ear_physiology	1.09946930
58	MP0003186_abnormal_redox_activity	1.09202267
59	MP0002693_abnormal_pancreas_physiology	1.08884548
60	MP0003122_maternal_imprinting	1.07234091
61	MP0005379_endocrine/exocrine_gland_phen	1.06300916
62	MP0000049_abnormal_middle_ear	1.00608193
63	MP0003635_abnormal_synaptic_transmissio	1.00142088
64	MP0001188_hyperpigmentation	0.97769399
65	MP0001944_abnormal_pancreas_morphology	0.97258925
66	MP0003195_calcinosis	0.96970895
67	MP0000778_abnormal_nervous_system	0.96468591
68	MP0003938_abnormal_ear_development	0.96217347
69	MP0002210_abnormal_sex_determination	0.95980078
70	MP0009697_abnormal_copulation	0.95214821
71	MP0003942_abnormal_urinary_system	0.94962607
72	MP0002557_abnormal_social/conspecific_i	0.94309949
73	MP0005551_abnormal_eye_electrophysiolog	0.94014624
74	MP0002184_abnormal_innervation	0.94013221
75	MP0000026_abnormal_inner_ear	0.92753646
76	MP0003937_abnormal_limbs/digits/tail_de	0.91416548
77	MP0002163_abnormal_gland_morphology	0.88637644
78	MP0001986_abnormal_taste_sensitivity	0.88025073
79	MP0002653_abnormal_ependyma_morphology	0.86615496
80	MP0000230_abnormal_systemic_arterial	0.85979392
81	MP0004924_abnormal_behavior	0.85508717
82	MP0005386_behavior/neurological_phenoty	0.85508717
83	MP0003880_abnormal_central_pattern	0.83222088
84	MP0008875_abnormal_xenobiotic_pharmacok	0.80844249
85	MP0003693_abnormal_embryo_hatching	0.80498821
86	MP0005645_abnormal_hypothalamus_physiol	0.80361824
87	MP0000372_irregular_coat_pigmentation	0.79896191
88	MP0003315_abnormal_perineum_morphology	0.79790013
89	MP0002234_abnormal_pharynx_morphology	0.79332356
90	MP0001919_abnormal_reproductive_system	0.79270910
91	MP0003959_abnormal_lean_body	0.78555047
92	MP0005389_reproductive_system_phenotype	0.75053844
93	MP0004145_abnormal_muscle_electrophysio	0.74629707
94	MP0001963_abnormal_hearing_physiology	0.74288117
95	MP0005332_abnormal_amino_acid	0.73323806
96	MP0010030_abnormal_orbit_morphology	0.72389070
97	MP0005464_abnormal_platelet_physiology	0.72380529
98	MP0004215_abnormal_myocardial_fiber	0.71986845
99	MP0001286_abnormal_eye_development	0.70017287
100	MP0001929_abnormal_gametogenesis	0.69631945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.74706514
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.23208879
3	Acute encephalopathy (HP:0006846)	4.06578771
4	Progressive macrocephaly (HP:0004481)	4.02926984
5	Septo-optic dysplasia (HP:0100842)	3.96740248
6	Mitochondrial inheritance (HP:0001427)	3.49159874
7	Nephronophthisis (HP:0000090)	3.37467212
8	Reticulocytopenia (HP:0001896)	3.35107018
9	Rib fusion (HP:0000902)	3.31171762
10	Abnormality of midbrain morphology (HP:0002418)	3.17224583
11	Molar tooth sign on MRI (HP:0002419)	3.17224583
12	Increased CSF lactate (HP:0002490)	3.06055625
13	Pancreatic fibrosis (HP:0100732)	3.05216807
14	Large for gestational age (HP:0001520)	2.98874657
15	Macrocytic anemia (HP:0001972)	2.97015808
16	Pancreatic cysts (HP:0001737)	2.95991887
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.95638021
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.95638021
19	Abnormal respiratory epithelium morphology (HP:0012253)	2.86352277
20	Abnormal respiratory motile cilium morphology (HP:0005938)	2.86352277
21	Abnormality of cells of the erythroid lineage (HP:0012130)	2.84540269
22	Optic nerve hypoplasia (HP:0000609)	2.81392907
23	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.79382986
24	Drooling (HP:0002307)	2.77798911
25	True hermaphroditism (HP:0010459)	2.77715871
26	Abnormal ciliary motility (HP:0012262)	2.77114801
27	Cerebral edema (HP:0002181)	2.74739652
28	Abnormal pupillary function (HP:0007686)	2.74039698
29	Congenital, generalized hypertrichosis (HP:0004540)	2.63213213
30	Constricted visual fields (HP:0001133)	2.62598112
31	Abnormal number of erythroid precursors (HP:0012131)	2.62262117
32	Agitation (HP:0000713)	2.59816256
33	Abnormality of the renal medulla (HP:0100957)	2.56630520
34	Focal motor seizures (HP:0011153)	2.56561962
35	Excessive salivation (HP:0003781)	2.55227443
36	3-Methylglutaconic aciduria (HP:0003535)	2.49508753
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.48614283
38	Renal Fanconi syndrome (HP:0001994)	2.47666907
39	Increased hepatocellular lipid droplets (HP:0006565)	2.46054368
40	Colon cancer (HP:0003003)	2.31845603
41	Absence seizures (HP:0002121)	2.25883787
42	Abnormality of the renal cortex (HP:0011035)	2.25509950
43	Poor suck (HP:0002033)	2.22408715
44	Stomatitis (HP:0010280)	2.21862757
45	Limb dystonia (HP:0002451)	2.20431192
46	Optic disc pallor (HP:0000543)	2.19463629
47	Bony spicule pigmentary retinopathy (HP:0007737)	2.17749823
48	Sclerocornea (HP:0000647)	2.15554516
49	Hepatocellular necrosis (HP:0001404)	2.15308916
50	Hyperinsulinemic hypoglycemia (HP:0000825)	2.14293475
51	Absent septum pellucidum (HP:0001331)	2.10777344
52	Degeneration of anterior horn cells (HP:0002398)	2.07730776
53	Abnormality of the anterior horn cell (HP:0006802)	2.07730776
54	Medial flaring of the eyebrow (HP:0010747)	2.07688065
55	Hepatic necrosis (HP:0002605)	2.04837733
56	Decreased muscle mass (HP:0003199)	2.04044224
57	Dialeptic seizures (HP:0011146)	2.03310731
58	Leukodystrophy (HP:0002415)	2.02178416
59	Lactic acidosis (HP:0003128)	2.00919900
60	Rhinitis (HP:0012384)	1.98798326
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97109661
62	Lipid accumulation in hepatocytes (HP:0006561)	1.96634531
63	Maternal diabetes (HP:0009800)	1.95973859
64	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.94312844
65	Male pseudohermaphroditism (HP:0000037)	1.93920181
66	Methylmalonic acidemia (HP:0002912)	1.91210801
67	Bile duct proliferation (HP:0001408)	1.90778252
68	Abnormal biliary tract physiology (HP:0012439)	1.90778252
69	Increased serum lactate (HP:0002151)	1.89841387
70	Tubular atrophy (HP:0000092)	1.89739269
71	Progressive microcephaly (HP:0000253)	1.88257293
72	Delayed myelination (HP:0012448)	1.87590632
73	Renal cortical cysts (HP:0000803)	1.87561213
74	Spastic tetraplegia (HP:0002510)	1.85839658
75	Rimmed vacuoles (HP:0003805)	1.85616550
76	Broad-based gait (HP:0002136)	1.85591565
77	Abnormality of the pons (HP:0007361)	1.84178593
78	Pallor (HP:0000980)	1.83765640
79	Abolished electroretinogram (ERG) (HP:0000550)	1.82580005
80	Occipital encephalocele (HP:0002085)	1.80452593
81	X-linked dominant inheritance (HP:0001423)	1.80045177
82	Increased mean platelet volume (HP:0011877)	1.79890201
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78660248
84	Chorioretinal coloboma (HP:0000567)	1.77137044
85	Growth hormone deficiency (HP:0000824)	1.74533215
86	Febrile seizures (HP:0002373)	1.73653136
87	Chronic hepatic failure (HP:0100626)	1.71467258
88	Hypothermia (HP:0002045)	1.71441259
89	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71412998
90	Absent/shortened dynein arms (HP:0200106)	1.71412998
91	Abnormality of renal resorption (HP:0011038)	1.69967392
92	Exertional dyspnea (HP:0002875)	1.69610705
93	Gonadotropin excess (HP:0000837)	1.69404044
94	Hypoplasia of the pons (HP:0012110)	1.68427075
95	Furrowed tongue (HP:0000221)	1.68221138
96	Respiratory failure (HP:0002878)	1.68042055
97	Hemiparesis (HP:0001269)	1.67470614
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.67348678
99	Abnormal rod and cone electroretinograms (HP:0008323)	1.66999657
100	Abnormality of the septum pellucidum (HP:0007375)	1.66508322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	3.84479934
2	PNCK	3.83258967
3	NUAK1	3.75076133
4	VRK2	2.53740651
5	MAP3K12	2.46417928
6	WNK4	2.35527551
7	ZAK	2.34687069
8	VRK1	2.33069631
9	WNK3	2.31696440
10	PLK4	2.26204287
11	STK16	2.14038428
12	PIK3CA	2.11984748
13	BMPR1B	2.07823701
14	TNIK	1.90868225
15	DYRK2	1.87507785
16	CDC7	1.87088934
17	BUB1	1.80556276
18	MST4	1.77940315
19	ADRBK2	1.76826447
20	GRK1	1.73217239
21	CASK	1.69528829
22	WEE1	1.53253466
23	PAK3	1.49285652
24	TEC	1.44533067
25	MKNK1	1.42855506
26	BCKDK	1.37051267
27	LATS1	1.36860596
28	MAPK13	1.34067196
29	NME1	1.31977050
30	PLK3	1.31129116
31	TYRO3	1.30998671
32	PRKCG	1.29464303
33	PINK1	1.14599869
34	MARK1	1.10804654
35	TIE1	1.08936227
36	EIF2AK1	1.07842634
37	MYLK	1.03733863
38	MAP3K4	0.97563178
39	DAPK2	0.96575160
40	STK3	0.94472741
41	STK39	0.92070271
42	ITK	0.91313512
43	TLK1	0.90451142
44	FRK	0.87195275
45	DAPK3	0.86686866
46	BRSK2	0.82336036
47	MKNK2	0.81770489
48	CDK3	0.76209024
49	CDK19	0.75866002
50	MAPKAPK5	0.74595245
51	ADRBK1	0.73543805
52	UHMK1	0.72838077
53	PLK2	0.70692919
54	CHEK2	0.70306814
55	MINK1	0.67490850
56	PRKCE	0.66931051
57	PKN1	0.66510031
58	TAOK3	0.65430716
59	CAMK2A	0.64848759
60	DYRK1A	0.64634880
61	WNK1	0.62796110
62	EIF2AK2	0.61819332
63	IKBKB	0.60901903
64	PLK1	0.59329236
65	CSNK2A2	0.58761160
66	CSNK1G2	0.55838701
67	CDK8	0.52274915
68	CAMK1	0.48950609
69	EPHB2	0.48900786
70	CSNK2A1	0.48166281
71	PTK2B	0.48109461
72	PRKCQ	0.47988233
73	MAPK15	0.46950671
74	MAP2K7	0.46733157
75	CSNK1E	0.46048502
76	NTRK3	0.45332320
77	CSNK1G1	0.44918482
78	DYRK3	0.43497398
79	MAP2K6	0.43217959
80	PRKACA	0.42257899
81	PRKACB	0.41396905
82	INSRR	0.38477230
83	MAP4K2	0.37755524
84	BTK	0.37580508
85	PRKG1	0.37091557
86	GRK5	0.37003345
87	CHUK	0.36803190
88	NEK1	0.36761517
89	CAMK1G	0.36089519
90	CSNK1A1	0.35392038
91	PHKG2	0.33994428
92	PHKG1	0.33994428
93	ILK	0.33347255
94	PRKCA	0.33100550
95	CAMK2D	0.31621301
96	IRAK4	0.31507893
97	MAP3K9	0.30488954
98	ACVR1B	0.29721249
99	STK38L	0.29602813
100	PASK	0.28620667

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.48826581
2	Ribosome_Homo sapiens_hsa03010	4.15257489
3	Parkinsons disease_Homo sapiens_hsa05012	3.86646940
4	Protein export_Homo sapiens_hsa03060	3.56849185
5	Alzheimers disease_Homo sapiens_hsa05010	2.56950694
6	Huntingtons disease_Homo sapiens_hsa05016	2.46005221
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.43965853
8	Proteasome_Homo sapiens_hsa03050	2.26498802
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.23010453
10	Mismatch repair_Homo sapiens_hsa03430	2.20685985
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.15363416
12	RNA polymerase_Homo sapiens_hsa03020	2.12290865
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.06415784
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99462199
15	Homologous recombination_Homo sapiens_hsa03440	1.95271020
16	Basal transcription factors_Homo sapiens_hsa03022	1.77915122
17	Asthma_Homo sapiens_hsa05310	1.67892697
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.64490557
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64489368
20	One carbon pool by folate_Homo sapiens_hsa00670	1.53941781
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53339686
22	RNA degradation_Homo sapiens_hsa03018	1.52116129
23	Folate biosynthesis_Homo sapiens_hsa00790	1.48701509
24	DNA replication_Homo sapiens_hsa03030	1.41097303
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.39770413
26	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.38529761
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35637374
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32702795
29	Nicotine addiction_Homo sapiens_hsa05033	1.30614981
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30602098
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30428498
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30141259
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.25678628
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.23069533
35	Butanoate metabolism_Homo sapiens_hsa00650	1.21193596
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.17430157
37	Serotonergic synapse_Homo sapiens_hsa04726	1.15887740
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14135560
39	Base excision repair_Homo sapiens_hsa03410	1.11415588
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.07754169
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04596346
42	Sulfur metabolism_Homo sapiens_hsa00920	1.03125429
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02156195
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.99525284
45	Phototransduction_Homo sapiens_hsa04744	0.97497865
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.96012805
47	GABAergic synapse_Homo sapiens_hsa04727	0.86021825
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.84362913
49	Olfactory transduction_Homo sapiens_hsa04740	0.82728830
50	Purine metabolism_Homo sapiens_hsa00230	0.75190038
51	Morphine addiction_Homo sapiens_hsa05032	0.72818249
52	Spliceosome_Homo sapiens_hsa03040	0.72328897
53	Circadian entrainment_Homo sapiens_hsa04713	0.70649509
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69992736
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.66311141
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.65708286
57	RNA transport_Homo sapiens_hsa03013	0.64565473
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62693900
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62426113
60	Metabolic pathways_Homo sapiens_hsa01100	0.62334214
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61926635
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60833178
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60323310
64	Allograft rejection_Homo sapiens_hsa05330	0.56855224
65	Insulin secretion_Homo sapiens_hsa04911	0.56787853
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52761672
67	Propanoate metabolism_Homo sapiens_hsa00640	0.52143823
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50550451
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.50361949
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50353497
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48481208
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.48445932
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47064464
74	Cocaine addiction_Homo sapiens_hsa05030	0.45492785
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44300915
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.43796707
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41991154
78	Amphetamine addiction_Homo sapiens_hsa05031	0.40629987
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.40185750
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38725640
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38433874
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37921184
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36747568
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34933733
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.34549339
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34493194
87	Taste transduction_Homo sapiens_hsa04742	0.32857928
88	p53 signaling pathway_Homo sapiens_hsa04115	0.32552493
89	Peroxisome_Homo sapiens_hsa04146	0.31590117
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29100162
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28209586
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27447402
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26063595
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25949199
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.25737065
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.25533419
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25460432
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24108622
99	Fatty acid elongation_Homo sapiens_hsa00062	0.24067736
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23561760

RPL23AP24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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