ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	7.05297468
2	protein neddylation (GO:0045116)	6.53433980
3	piRNA metabolic process (GO:0034587)	6.07625928
4	chromosome organization involved in meiosis (GO:0070192)	5.93450811
5	regulation of meiosis I (GO:0060631)	5.41665143
6	male meiosis I (GO:0007141)	5.32958463
7	synaptonemal complex assembly (GO:0007130)	5.31844527
8	meiosis I (GO:0007127)	5.27711047
9	acrosome reaction (GO:0007340)	5.25434497
10	fusion of sperm to egg plasma membrane (GO:0007342)	5.10415827
11	synaptonemal complex organization (GO:0070193)	4.84562462
12	microtubule depolymerization (GO:0007019)	4.76545419
13	male meiosis (GO:0007140)	4.69838808
14	neutrophil activation involved in immune response (GO:0002283)	4.56892042
15	binding of sperm to zona pellucida (GO:0007339)	4.42387317
16	DNA synthesis involved in DNA repair (GO:0000731)	4.38743058
17	DNA methylation involved in gamete generation (GO:0043046)	4.30619966
18	microtubule polymerization or depolymerization (GO:0031109)	4.19703364
19	meiotic nuclear division (GO:0007126)	4.17944406
20	protoporphyrinogen IX metabolic process (GO:0046501)	4.16674918
21	protein maturation by protein folding (GO:0022417)	4.13896158
22	histone exchange (GO:0043486)	4.09380905
23	sperm-egg recognition (GO:0035036)	4.08602217
24	meiotic cell cycle process (GO:1903046)	4.04549417
25	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.92168847
26	meiotic chromosome segregation (GO:0045132)	3.91403567
27	gonadal mesoderm development (GO:0007506)	3.81203067
28	polyamine biosynthetic process (GO:0006596)	3.80307894
29	resolution of meiotic recombination intermediates (GO:0000712)	3.75474435
30	CENP-A containing nucleosome assembly (GO:0034080)	3.69633774
31	negative regulation of heart rate (GO:0010459)	3.69416096
32	plasma membrane fusion (GO:0045026)	3.68743247
33	sperm motility (GO:0030317)	3.66061388
34	regulation of cilium movement (GO:0003352)	3.65406738
35	negative regulation of appetite (GO:0032099)	3.58994835
36	negative regulation of response to food (GO:0032096)	3.58994835
37	proteasome assembly (GO:0043248)	3.53462944
38	centriole replication (GO:0007099)	3.46822401
39	chromatin remodeling at centromere (GO:0031055)	3.45652131
40	DNA packaging (GO:0006323)	3.42120473
41	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.40212015
42	telomere maintenance via semi-conservative replication (GO:0032201)	3.39766873
43	DNA replication checkpoint (GO:0000076)	3.38362480
44	deoxyribonucleotide biosynthetic process (GO:0009263)	3.35786108
45	protein-cofactor linkage (GO:0018065)	3.32259639
46	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.31337379
47	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	3.30225559
48	oxygen transport (GO:0015671)	3.27358867
49	spermatid nucleus differentiation (GO:0007289)	3.23617986
50	multicellular organism reproduction (GO:0032504)	3.22781977
51	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.22713801
52	chromosome condensation (GO:0030261)	3.13635794
53	cell-cell recognition (GO:0009988)	3.13410453
54	mitotic metaphase plate congression (GO:0007080)	3.10437099
55	deoxyribose phosphate biosynthetic process (GO:0046385)	3.09614888
56	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.09614888
57	mitotic chromosome condensation (GO:0007076)	3.09479763
58	IMP biosynthetic process (GO:0006188)	3.01816236
59	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.01603129
60	DNA double-strand break processing (GO:0000729)	3.00488355
61	reciprocal DNA recombination (GO:0035825)	2.98654305
62	reciprocal meiotic recombination (GO:0007131)	2.98654305
63	centriole assembly (GO:0098534)	2.97682988
64	DNA catabolic process, exonucleolytic (GO:0000738)	2.95298519
65	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.95104851
66	gas transport (GO:0015669)	2.94635181
67	neurofilament cytoskeleton organization (GO:0060052)	2.90857922
68	DNA replication-independent nucleosome organization (GO:0034724)	2.89589905
69	DNA replication-independent nucleosome assembly (GO:0006336)	2.89589905
70	kinetochore assembly (GO:0051382)	2.84956878
71	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.83404046
72	adenosine receptor signaling pathway (GO:0001973)	2.82326804
73	meiotic cell cycle (GO:0051321)	2.80992077
74	rRNA methylation (GO:0031167)	2.79902881
75	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.78815202
76	pentose metabolic process (GO:0019321)	2.78431759
77	kinetochore organization (GO:0051383)	2.77407336
78	cellular biogenic amine biosynthetic process (GO:0042401)	2.76811570
79	porphyrin-containing compound biosynthetic process (GO:0006779)	2.76638337
80	regulation of centriole replication (GO:0046599)	2.75054569
81	negative regulation of norepinephrine secretion (GO:0010700)	2.72166011
82	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.71742830
83	L-phenylalanine metabolic process (GO:0006558)	2.71742830
84	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.68047005
85	negative regulation of meiosis (GO:0045835)	2.67666525
86	telomere maintenance via telomere lengthening (GO:0010833)	2.66453042
87	positive regulation of meiosis (GO:0045836)	2.64293579
88	sister chromatid cohesion (GO:0007062)	2.62623017
89	spermatid development (GO:0007286)	2.62458583
90	DNA strand elongation involved in DNA replication (GO:0006271)	2.62141802
91	protein K6-linked ubiquitination (GO:0085020)	2.61711386
92	N-terminal protein amino acid acetylation (GO:0006474)	2.61330298
93	porphyrin-containing compound metabolic process (GO:0006778)	2.61178604
94	chaperone-mediated protein transport (GO:0072321)	2.60807608
95	telomere maintenance via recombination (GO:0000722)	2.59847476
96	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.58396557
97	calcium ion-dependent exocytosis (GO:0017156)	2.57671956
98	spermatogenesis (GO:0007283)	2.55611037
99	DNA strand elongation (GO:0022616)	2.55323002
100	male gamete generation (GO:0048232)	2.54754524

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.22347340
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54899855
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.32257039
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.06129486
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.98156221
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.74137760
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59015547
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.53915150
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.50650494
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.49746460
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.48912566
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.35968558
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30699297
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25465089
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.18957788
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.11924271
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.11550525
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03535194
19	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.01985512
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99987654
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.98837886
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.94446893
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.92302638
24	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.89937773
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.89266873
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.88224058
27	GATA1_19941826_ChIP-Seq_K562_Human	1.86582332
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84186032
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.79301032
30	VDR_22108803_ChIP-Seq_LS180_Human	1.78673326
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.62241935
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.60420113
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.60398221
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.58785721
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.56424158
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.52402131
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51457211
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.50965974
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50603982
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50342116
41	GATA2_19941826_ChIP-Seq_K562_Human	1.49857681
42	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.49660670
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.46745431
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44277132
45	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.42045421
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41036064
47	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.35329879
48	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33273656
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33046973
50	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32093083
51	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30312820
52	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29484217
53	NCOR1_26117541_ChIP-Seq_K562_Human	1.27296810
54	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.25271862
55	EZH2_22144423_ChIP-Seq_EOC_Human	1.24184377
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23844190
57	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.23697874
58	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.23037786
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.21119675
60	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20489528
61	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.19423517
62	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.18575780
63	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18462351
64	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.18455413
65	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18284982
66	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17776078
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16389613
68	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.15192048
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14356037
70	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.14082714
71	SPI1_20517297_ChIP-Seq_HL60_Human	1.13734731
72	KDM5A_27292631_Chip-Seq_BREAST_Human	1.11396770
73	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.08422681
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.08071108
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05824083
76	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05448514
77	XRN2_22483619_ChIP-Seq_HELA_Human	1.02607152
78	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.00199371
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00143960
80	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.97136129
81	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.96959980
82	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95213672
83	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94828007
84	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94599238
85	BCL6_27268052_Chip-Seq_Bcells_Human	0.93990295
86	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93230677
87	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93077068
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92475578
89	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.92207891
90	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.90088792
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89693104
92	TFEB_21752829_ChIP-Seq_HELA_Human	0.89433565
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89354674
94	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.89050555
95	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.88765250
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.87640450
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87472507
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.87059731
99	MYC_18940864_ChIP-ChIP_HL60_Human	0.87036164
100	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.86608697

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	4.88015848
2	MP0005410_abnormal_fertilization	4.57122567
3	MP0008058_abnormal_DNA_repair	4.17492143
4	MP0008877_abnormal_DNA_methylation	3.21058696
5	MP0004147_increased_porphyrin_level	3.13414143
6	MP0010094_abnormal_chromosome_stability	3.09193693
7	MP0001929_abnormal_gametogenesis	2.86033451
8	MP0002210_abnormal_sex_determination	2.53534090
9	MP0008004_abnormal_stomach_pH	2.49027324
10	MP0003111_abnormal_nucleus_morphology	2.48110359
11	MP0003698_abnormal_male_reproductive	2.47477396
12	MP0002736_abnormal_nociception_after	2.42172102
13	MP0005084_abnormal_gallbladder_morpholo	2.38703764
14	MP0004957_abnormal_blastocyst_morpholog	2.34149413
15	MP0003656_abnormal_erythrocyte_physiolo	2.32385538
16	MP0003693_abnormal_embryo_hatching	2.29887034
17	MP0003806_abnormal_nucleotide_metabolis	2.22935622
18	MP0005083_abnormal_biliary_tract	2.21291537
19	MP0006036_abnormal_mitochondrial_physio	2.18677889
20	MP0002653_abnormal_ependyma_morphology	2.18265537
21	MP0006035_abnormal_mitochondrial_morpho	2.15635258
22	MP0003646_muscle_fatigue	2.14652319
23	MP0003718_maternal_effect	2.11715723
24	MP0008007_abnormal_cellular_replicative	2.10127211
25	MP0003077_abnormal_cell_cycle	2.02912571
26	MP0002132_abnormal_respiratory_system	1.98651883
27	MP0003186_abnormal_redox_activity	1.97994569
28	MP0005377_hearing/vestibular/ear_phenot	1.88698496
29	MP0003878_abnormal_ear_physiology	1.88698496
30	MP0001145_abnormal_male_reproductive	1.79345909
31	MP0000653_abnormal_sex_gland	1.77751443
32	MP0000343_altered_response_to	1.71184857
33	MP0008932_abnormal_embryonic_tissue	1.68394540
34	MP0008260_abnormal_autophagy	1.67113327
35	MP0009697_abnormal_copulation	1.64304047
36	MP0001545_abnormal_hematopoietic_system	1.61987871
37	MP0005397_hematopoietic_system_phenotyp	1.61987871
38	MP0003879_abnormal_hair_cell	1.59430125
39	MP0001968_abnormal_touch/_nociception	1.59236800
40	MP0000358_abnormal_cell_content/	1.52771183
41	MP0002161_abnormal_fertility/fecundity	1.46602929
42	MP0001529_abnormal_vocalization	1.37235258
43	MP0001764_abnormal_homeostasis	1.31563333
44	MP0001485_abnormal_pinna_reflex	1.24628617
45	MP0003786_premature_aging	1.18681339
46	MP0004742_abnormal_vestibular_system	1.17828184
47	MP0000313_abnormal_cell_death	1.03041192
48	MP0002102_abnormal_ear_morphology	1.02677215
49	MP0009333_abnormal_splenocyte_physiolog	0.99385450
50	MP0003136_yellow_coat_color	0.97998013
51	MP0008775_abnormal_heart_ventricle	0.91715098
52	MP0002160_abnormal_reproductive_system	0.89236407
53	MP0005645_abnormal_hypothalamus_physiol	0.89209781
54	MP0001119_abnormal_female_reproductive	0.88644508
55	MP0000230_abnormal_systemic_arterial	0.88324127
56	MP0005636_abnormal_mineral_homeostasis	0.87600251
57	MP0001730_embryonic_growth_arrest	0.85885789
58	MP0006276_abnormal_autonomic_nervous	0.85447609
59	MP0003699_abnormal_female_reproductive	0.85204251
60	MP0008872_abnormal_physiological_respon	0.85121649
61	MP0008995_early_reproductive_senescence	0.84123164
62	MP0001188_hyperpigmentation	0.83711944
63	MP0000678_abnormal_parathyroid_gland	0.81917081
64	MP0001905_abnormal_dopamine_level	0.78250887
65	MP0002398_abnormal_bone_marrow	0.78118415
66	MP0010307_abnormal_tumor_latency	0.77720804
67	MP0004215_abnormal_myocardial_fiber	0.74857771
68	MP0009046_muscle_twitch	0.72958735
69	MP0000350_abnormal_cell_proliferation	0.72921131
70	MP0000015_abnormal_ear_pigmentation	0.72812844
71	MP0005332_abnormal_amino_acid	0.71959785
72	MP0004142_abnormal_muscle_tone	0.71472481
73	MP0005384_cellular_phenotype	0.68853413
74	MP0009278_abnormal_bone_marrow	0.68549954
75	MP0005501_abnormal_skin_physiology	0.67415050
76	MP0001879_abnormal_lymphatic_vessel	0.66890904
77	MP0003724_increased_susceptibility_to	0.66646949
78	MP0001697_abnormal_embryo_size	0.65575309
79	MP0009763_increased_sensitivity_to	0.65151383
80	MP0001835_abnormal_antigen_presentation	0.64994998
81	MP0005535_abnormal_body_temperature	0.64668392
82	MP0008874_decreased_physiological_sensi	0.63309935
83	MP0002229_neurodegeneration	0.62863085
84	MP0002067_abnormal_sensory_capabilities	0.62726250
85	MP0002429_abnormal_blood_cell	0.62533139
86	MP0002877_abnormal_melanocyte_morpholog	0.61583276
87	MP0002722_abnormal_immune_system	0.61413345
88	MP0002080_prenatal_lethality	0.60385844
89	MP0009765_abnormal_xenobiotic_induced	0.60384076
90	MP0002332_abnormal_exercise_endurance	0.59894902
91	MP0002019_abnormal_tumor_incidence	0.58819334
92	MP0001727_abnormal_embryo_implantation	0.58078474
93	MP0002733_abnormal_thermal_nociception	0.56977413
94	MP0005389_reproductive_system_phenotype	0.55883699
95	MP0009764_decreased_sensitivity_to	0.55639661
96	MP0002837_dystrophic_cardiac_calcinosis	0.55446413
97	MP0001963_abnormal_hearing_physiology	0.54823579
98	MP0002095_abnormal_skin_pigmentation	0.53479568
99	MP0000490_abnormal_crypts_of	0.51290527
100	MP0001970_abnormal_pain_threshold	0.50118947

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.69639170
2	Prolonged bleeding time (HP:0003010)	5.00483984
3	Cholecystitis (HP:0001082)	4.37875002
4	Abnormal gallbladder physiology (HP:0012438)	4.37875002
5	Paralysis (HP:0003470)	4.37185335
6	Upper limb muscle weakness (HP:0003484)	4.32329128
7	Renal Fanconi syndrome (HP:0001994)	4.27461975
8	Menorrhagia (HP:0000132)	4.19939422
9	Poikilocytosis (HP:0004447)	4.17599180
10	Petechiae (HP:0000967)	4.03012795
11	Hyperlipoproteinemia (HP:0010980)	3.83129674
12	Dyschromatopsia (HP:0007641)	3.66024949
13	Increased mean platelet volume (HP:0011877)	3.48739913
14	Purpura (HP:0000979)	3.31146087
15	Abnormal platelet volume (HP:0011876)	3.26978744
16	Cholelithiasis (HP:0001081)	3.15376549
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.11877388
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.11877388
19	Abnormality of DNA repair (HP:0003254)	3.10852244
20	Acanthocytosis (HP:0001927)	3.06331396
21	Epistaxis (HP:0000421)	3.04114095
22	Increased intramyocellular lipid droplets (HP:0012240)	3.04014093
23	Ileus (HP:0002595)	3.02719457
24	Generalized aminoaciduria (HP:0002909)	2.97535773
25	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.97167469
26	Acute encephalopathy (HP:0006846)	2.94641035
27	Exertional dyspnea (HP:0002875)	2.94411760
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91700564
29	Abnormality of lateral ventricle (HP:0030047)	2.88400789
30	Abnormal gallbladder morphology (HP:0012437)	2.86863388
31	Nausea (HP:0002018)	2.86402831
32	Chromsome breakage (HP:0040012)	2.86163045
33	Acute necrotizing encephalopathy (HP:0006965)	2.82473593
34	Abnormal hemoglobin (HP:0011902)	2.79400055
35	Abnormal spermatogenesis (HP:0008669)	2.68858977
36	Abnormal ciliary motility (HP:0012262)	2.67491604
37	Abnormality of renal resorption (HP:0011038)	2.66809650
38	Male infertility (HP:0003251)	2.62708238
39	Increased hepatocellular lipid droplets (HP:0006565)	2.55172983
40	Reticulocytosis (HP:0001923)	2.52935241
41	Impaired platelet aggregation (HP:0003540)	2.51088497
42	Abnormal platelet function (HP:0011869)	2.51088497
43	Entropion (HP:0000621)	2.50226979
44	Dysautonomia (HP:0002459)	2.46226941
45	Acute hepatic failure (HP:0006554)	2.45466021
46	Increased muscle lipid content (HP:0009058)	2.41823667
47	Hypophosphatemic rickets (HP:0004912)	2.41478420
48	Azoospermia (HP:0000027)	2.36884468
49	Abnormality of reticulocytes (HP:0004312)	2.35865559
50	Abnormality of the labia minora (HP:0012880)	2.34640123
51	Increased CSF lactate (HP:0002490)	2.28196670
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27538466
53	Abnormality of alanine metabolism (HP:0010916)	2.27538466
54	Hyperalaninemia (HP:0003348)	2.27538466
55	Abnormality of the gallbladder (HP:0005264)	2.27321064
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26730303
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.26730303
58	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.24211492
59	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.24211492
60	Thyroid-stimulating hormone excess (HP:0002925)	2.21464033
61	Progressive macrocephaly (HP:0004481)	2.16757247
62	Mitochondrial inheritance (HP:0001427)	2.16347330
63	Hepatic necrosis (HP:0002605)	2.16250747
64	Papillary thyroid carcinoma (HP:0002895)	2.15415755
65	Abnormal pupillary function (HP:0007686)	2.15106437
66	Spontaneous abortion (HP:0005268)	2.13462104
67	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13259116
68	Lipid accumulation in hepatocytes (HP:0006561)	2.13089462
69	Hyperglycinemia (HP:0002154)	2.09849070
70	Ectopic kidney (HP:0000086)	2.08479872
71	Respiratory difficulties (HP:0002880)	2.08161754
72	Ulnar claw (HP:0001178)	2.02030122
73	Decreased central vision (HP:0007663)	2.01006811
74	Reticulocytopenia (HP:0001896)	1.99829565
75	Hypochromic microcytic anemia (HP:0004840)	1.98026221
76	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.97689435
77	Poikiloderma (HP:0001029)	1.96822663
78	Infertility (HP:0000789)	1.96499851
79	Polycythemia (HP:0001901)	1.96404049
80	Tinnitus (HP:0000360)	1.96373320
81	Hepatosplenomegaly (HP:0001433)	1.96123635
82	Meckel diverticulum (HP:0002245)	1.95426367
83	Microcytic anemia (HP:0001935)	1.91749468
84	Degeneration of anterior horn cells (HP:0002398)	1.90183403
85	Abnormality of the anterior horn cell (HP:0006802)	1.90183403
86	Conjunctival telangiectasia (HP:0000524)	1.89195135
87	Abnormal hair whorl (HP:0010721)	1.88683245
88	Abnormality of the ileum (HP:0001549)	1.88552194
89	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.88416997
90	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.88333427
91	Glycosuria (HP:0003076)	1.87854426
92	Abnormality of urine glucose concentration (HP:0011016)	1.87854426
93	Increased serum lactate (HP:0002151)	1.84395739
94	Abnormality of the preputium (HP:0100587)	1.82621778
95	Duplicated collecting system (HP:0000081)	1.82445230
96	Gingival bleeding (HP:0000225)	1.80457193
97	Cerebral edema (HP:0002181)	1.77873488
98	Impaired vibration sensation in the lower limbs (HP:0002166)	1.77445236
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76292408
100	Progressive external ophthalmoplegia (HP:0000590)	1.76032585

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	5.73875303
2	MST4	4.85605788
3	PLK4	3.90081971
4	STK16	3.34400502
5	BMX	3.19734010
6	EIF2AK3	3.04062401
7	MAP4K2	3.00275814
8	RIPK4	2.57135865
9	MAP3K12	2.22362450
10	TTK	2.21528605
11	PNCK	2.18013033
12	ZAK	2.16575050
13	PLK2	2.11227829
14	MYLK	1.94635065
15	BUB1	1.90173304
16	PTK2B	1.80402908
17	BMPR1B	1.73778288
18	ACVR1B	1.72494317
19	CDC7	1.70290012
20	NEK1	1.62547534
21	TEC	1.60010220
22	PLK3	1.36614138
23	BTK	1.33028290
24	GRK5	1.32116938
25	CCNB1	1.22195877
26	CDK19	1.14869870
27	MAP3K11	1.14220601
28	ARAF	1.12028543
29	NME1	1.09679109
30	DYRK3	1.08259391
31	PLK1	1.06184832
32	VRK1	1.05179501
33	PBK	1.01110127
34	PAK1	1.00321909
35	TSSK6	0.98382755
36	AURKA	0.94862684
37	BMPR2	0.91490513
38	ILK	0.90744699
39	TLK1	0.89882408
40	BRAF	0.88769956
41	PIM2	0.87548905
42	ATR	0.87376916
43	CDK8	0.85653362
44	ADRBK2	0.85155940
45	MAPKAPK3	0.84033323
46	TESK1	0.81721140
47	EPHB1	0.80739227
48	STK3	0.77457465
49	MAP3K5	0.77336163
50	BRSK1	0.74393801
51	MARK3	0.72521779
52	STK4	0.71199181
53	SYK	0.70971538
54	TAOK3	0.67772909
55	PDK2	0.67495784
56	DAPK3	0.67066142
57	FGR	0.65994201
58	PIM1	0.65943112
59	WEE1	0.65794448
60	BCKDK	0.65338712
61	MAP3K8	0.62758694
62	CAMK1G	0.62682028
63	TESK2	0.61775542
64	CSF1R	0.60844063
65	INSRR	0.59489825
66	TAOK2	0.57488533
67	ATM	0.56604834
68	KSR2	0.56365023
69	MAP3K2	0.52002713
70	MATK	0.49076940
71	IRAK3	0.48108743
72	TRIM28	0.47561503
73	MINK1	0.46147314
74	AURKB	0.43382098
75	RAF1	0.42322797
76	CDK14	0.42230400
77	IKBKB	0.42033927
78	CSNK2A2	0.41562232
79	PRKCG	0.40021975
80	CSNK2A1	0.39377967
81	CHEK1	0.37908196
82	BLK	0.37452447
83	PIK3CG	0.37148386
84	CLK1	0.37034974
85	WNK1	0.36672508
86	LYN	0.36312135
87	BCR	0.35980384
88	MAP3K1	0.35975090
89	SCYL2	0.34406013
90	GRK6	0.32749229
91	NTRK3	0.32562984
92	CHEK2	0.31102959
93	RPS6KA5	0.30425434
94	DAPK2	0.30413513
95	MST1R	0.28657931
96	STK10	0.27203751
97	TIE1	0.26891771
98	CAMK2A	0.26713956
99	ABL2	0.26233788
100	BRSK2	0.25377507

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	4.73965470
2	DNA replication_Homo sapiens_hsa03030	3.78107709
3	Homologous recombination_Homo sapiens_hsa03440	3.11617198
4	Proteasome_Homo sapiens_hsa03050	2.91918118
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.48657484
6	Nucleotide excision repair_Homo sapiens_hsa03420	2.45970600
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.36759597
8	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.34271107
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.18590280
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.07312279
11	RNA polymerase_Homo sapiens_hsa03020	2.07305528
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.06038501
13	Cell cycle_Homo sapiens_hsa04110	2.01112470
14	Collecting duct acid secretion_Homo sapiens_hsa04966	2.00626804
15	Basal transcription factors_Homo sapiens_hsa03022	1.95009111
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.94105085
17	Parkinsons disease_Homo sapiens_hsa05012	1.81663925
18	One carbon pool by folate_Homo sapiens_hsa00670	1.78023071
19	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.72460510
20	Huntingtons disease_Homo sapiens_hsa05016	1.71498575
21	Base excision repair_Homo sapiens_hsa03410	1.69458084
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64832635
23	RNA transport_Homo sapiens_hsa03013	1.64558314
24	Fatty acid elongation_Homo sapiens_hsa00062	1.61592430
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.56138081
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.50024097
27	Platelet activation_Homo sapiens_hsa04611	1.47218487
28	Purine metabolism_Homo sapiens_hsa00230	1.47109195
29	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.42116154
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.33864548
31	Oocyte meiosis_Homo sapiens_hsa04114	1.25796923
32	Glutathione metabolism_Homo sapiens_hsa00480	1.21151402
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.20307850
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19959540
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19745492
36	Ribosome_Homo sapiens_hsa03010	1.19592739
37	Folate biosynthesis_Homo sapiens_hsa00790	1.11130966
38	Olfactory transduction_Homo sapiens_hsa04740	1.10517860
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10220373
40	Protein export_Homo sapiens_hsa03060	1.07735681
41	Propanoate metabolism_Homo sapiens_hsa00640	1.07389879
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.06618618
43	Alcoholism_Homo sapiens_hsa05034	1.03010890
44	Carbon metabolism_Homo sapiens_hsa01200	1.02886384
45	Sulfur metabolism_Homo sapiens_hsa00920	1.00761855
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00705395
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.99361286
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97495570
49	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.96581803
50	RNA degradation_Homo sapiens_hsa03018	0.95864969
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92734936
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.88603540
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86736651
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86000792
55	Regulation of autophagy_Homo sapiens_hsa04140	0.83498303
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81521418
57	p53 signaling pathway_Homo sapiens_hsa04115	0.78148468
58	Sulfur relay system_Homo sapiens_hsa04122	0.74961888
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74162013
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73666812
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70430007
62	Spliceosome_Homo sapiens_hsa03040	0.68538659
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68241238
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.68094550
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.65265011
66	Legionellosis_Homo sapiens_hsa05134	0.64289572
67	Alzheimers disease_Homo sapiens_hsa05010	0.63987897
68	Metabolic pathways_Homo sapiens_hsa01100	0.63486611
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61556732
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.61043653
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58700845
72	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.58643060
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58490919
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54570740
75	Phototransduction_Homo sapiens_hsa04744	0.53479052
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52949951
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52103680
78	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49804050
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48492488
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.46629238
81	Endocytosis_Homo sapiens_hsa04144	0.43969847
82	Serotonergic synapse_Homo sapiens_hsa04726	0.43958048
83	Gap junction_Homo sapiens_hsa04540	0.43330956
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42592893
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.40878923
86	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.40481259
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40209317
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40111959
89	Butanoate metabolism_Homo sapiens_hsa00650	0.40049892
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38354365
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37054290
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.37027563
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.33459977
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29479694
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.29436820
96	Phagosome_Homo sapiens_hsa04145	0.27188986
97	Thyroid cancer_Homo sapiens_hsa05216	0.24915218
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24720787
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24564821
100	Shigellosis_Homo sapiens_hsa05131	0.24052953

RPL23AP25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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