ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	7.71288451
2	acrosome reaction (GO:0007340)	7.37624032
3	regulation of B cell receptor signaling pathway (GO:0050855)	6.94088974
4	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	6.92109366
5	sperm motility (GO:0030317)	6.87484334
6	response to pheromone (GO:0019236)	6.78760159
7	negative regulation of B cell proliferation (GO:0030889)	6.68131338
8	chromosome condensation (GO:0030261)	6.47926844
9	sperm capacitation (GO:0048240)	6.34539052
10	spermatid nucleus differentiation (GO:0007289)	6.26385605
11	plasma membrane fusion (GO:0045026)	6.20260597
12	single strand break repair (GO:0000012)	6.18122505
13	DNA packaging (GO:0006323)	6.08719894
14	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.00599317
15	rRNA methylation (GO:0031167)	5.98647113
16	regulation of mast cell degranulation (GO:0043304)	5.94695177
17	centriole replication (GO:0007099)	5.85240998
18	regulation of mast cell activation involved in immune response (GO:0033006)	5.58840476
19	rRNA modification (GO:0000154)	5.36297291
20	positive regulation of phosphatase activity (GO:0010922)	5.10150301
21	centriole assembly (GO:0098534)	4.97537325
22	sperm-egg recognition (GO:0035036)	4.81378352
23	negative regulation of alpha-beta T cell activation (GO:0046636)	4.79312517
24	sexual reproduction (GO:0019953)	4.68881074
25	binding of sperm to zona pellucida (GO:0007339)	4.62973237
26	multicellular organism reproduction (GO:0032504)	4.55102663
27	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.48924630
28	microtubule depolymerization (GO:0007019)	4.47239649
29	spermatid development (GO:0007286)	4.46008505
30	reproduction (GO:0000003)	4.43750418
31	cell-cell recognition (GO:0009988)	4.33318661
32	regulation of mast cell activation (GO:0033003)	4.31941245
33	peptidyl-histidine modification (GO:0018202)	4.31346707
34	negative regulation of leukocyte migration (GO:0002686)	4.31110258
35	axonemal dynein complex assembly (GO:0070286)	4.28308112
36	negative regulation of exocytosis (GO:0045920)	4.23062344
37	regulation of exit from mitosis (GO:0007096)	4.13592420
38	calcium ion-dependent exocytosis (GO:0017156)	4.11334694
39	regulation of T cell receptor signaling pathway (GO:0050856)	4.11190996
40	signal peptide processing (GO:0006465)	4.06620630
41	regulation of myeloid leukocyte mediated immunity (GO:0002886)	3.99843581
42	ketone body metabolic process (GO:1902224)	3.88490112
43	motile cilium assembly (GO:0044458)	3.82526984
44	maturation of 5.8S rRNA (GO:0000460)	3.80157372
45	regulation of leukocyte degranulation (GO:0043300)	3.74684294
46	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67711336
47	ATP synthesis coupled proton transport (GO:0015986)	3.67711336
48	response to hepatocyte growth factor (GO:0035728)	3.66647913
49	cellular response to hepatocyte growth factor stimulus (GO:0035729)	3.66647913
50	spermatogenesis (GO:0007283)	3.65277576
51	male gamete generation (GO:0048232)	3.63425794
52	epithelial cilium movement (GO:0003351)	3.60146930
53	chromatin silencing (GO:0006342)	3.60126415
54	histone mRNA catabolic process (GO:0071044)	3.55063535
55	cellular ketone body metabolic process (GO:0046950)	3.50050018
56	regulation of cilium movement (GO:0003352)	3.49588921
57	microtubule polymerization or depolymerization (GO:0031109)	3.43633501
58	negative regulation of inclusion body assembly (GO:0090084)	3.40789064
59	regulation of cell maturation (GO:1903429)	3.38223483
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.36323297
61	regulation of lipoprotein lipase activity (GO:0051004)	3.35353436
62	gamete generation (GO:0007276)	3.31854229
63	negative regulation of fibroblast proliferation (GO:0048147)	3.20084739
64	negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)	3.18785280
65	negative regulation of B cell activation (GO:0050869)	3.15474125
66	positive regulation of meiosis (GO:0045836)	3.15273426
67	regulation of Rab GTPase activity (GO:0032313)	3.14798520
68	positive regulation of Rab GTPase activity (GO:0032851)	3.14798520
69	response to redox state (GO:0051775)	3.11010166
70	cilium movement (GO:0003341)	3.09706584
71	protein polyglutamylation (GO:0018095)	3.08507716
72	formation of translation preinitiation complex (GO:0001731)	2.99286798
73	positive regulation of meiotic cell cycle (GO:0051446)	2.97353051
74	regulation of execution phase of apoptosis (GO:1900117)	2.97121324
75	cellular response to epinephrine stimulus (GO:0071872)	2.96960455
76	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.95234846
77	negative regulation of leukocyte mediated immunity (GO:0002704)	2.95045955
78	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.94467058
79	mitochondrial DNA replication (GO:0006264)	2.92385406
80	histone H4 deacetylation (GO:0070933)	2.88206329
81	regulation of regulated secretory pathway (GO:1903305)	2.86258056
82	nucleus organization (GO:0006997)	2.86168149
83	peptidyl-proline hydroxylation (GO:0019511)	2.84883479
84	single fertilization (GO:0007338)	2.84094117
85	4-hydroxyproline metabolic process (GO:0019471)	2.80903779
86	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78767082
87	NADH dehydrogenase complex assembly (GO:0010257)	2.78767082
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78767082
89	positive regulation of dephosphorylation (GO:0035306)	2.76596424
90	protein targeting to Golgi (GO:0000042)	2.74038037
91	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.69688438
92	ribosomal small subunit biogenesis (GO:0042274)	2.69538797
93	regulation of T cell mediated cytotoxicity (GO:0001914)	2.65135762
94	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.63866591
95	fertilization (GO:0009566)	2.63491410
96	multicellular organismal reproductive process (GO:0048609)	2.63470017
97	negative regulation of mast cell activation (GO:0033004)	12.0558060
98	regulation of activation of Janus kinase activity (GO:0010533)	11.3909316
99	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	11.3454872
100	negative regulation of phagocytosis (GO:0050765)	10.9656574

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.64937701
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.81776174
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.10492007
4	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.85536367
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.54970095
6	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.40391533
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.40093292
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38453966
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.36151973
10	BCL6_27268052_Chip-Seq_Bcells_Human	2.34464754
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.29995176
12	BCOR_27268052_Chip-Seq_Bcells_Human	2.08304931
13	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	2.03729132
14	ERG_20517297_ChIP-Seq_VCAP_Human	2.02583433
15	ERA_21632823_ChIP-Seq_H3396_Human	2.02019152
16	TAF2_19829295_ChIP-Seq_ESCs_Human	2.01521557
17	E2F1_20622854_ChIP-Seq_HELA_Human	1.99676876
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99463663
19	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.95504832
20	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.92477132
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.90523139
22	RAC3_21632823_ChIP-Seq_H3396_Human	1.89032548
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.87235158
24	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.87022476
25	P68_20966046_ChIP-Seq_HELA_Human	1.83421655
26	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.80342297
27	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.78967298
28	P300_27268052_Chip-Seq_Bcells_Human	1.77178602
29	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.72490134
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.71627938
31	CTCF_27219007_Chip-Seq_Bcells_Human	1.63147063
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59505460
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.58557832
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57544525
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.54517863
36	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.51419751
37	FUS_26573619_Chip-Seq_HEK293_Human	1.50850435
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50608225
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.50608225
40	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.45827271
41	PHF8_20622854_ChIP-Seq_HELA_Human	1.43505243
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36078451
43	SA1_27219007_Chip-Seq_Bcells_Human	1.34751808
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33429698
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.32703143
46	SMC4_20622854_ChIP-Seq_HELA_Human	1.31254644
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.28157368
48	LXR_22292898_ChIP-Seq_THP-1_Human	1.26521610
49	TP63_22573176_ChIP-Seq_HFKS_Human	1.25075098
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23705065
51	SOX2_21211035_ChIP-Seq_LN229_Human	1.23286430
52	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22522808
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22310538
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22310538
55	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.21685303
56	STAT1_20625510_ChIP-Seq_HELA_Human	1.19826066
57	RUNX_20019798_ChIP-Seq_JUKART_Human	1.19775463
58	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.18935779
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17545768
60	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15501948
61	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.15412245
62	NCOR_22424771_ChIP-Seq_293T_Human	1.15111859
63	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.14461593
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13431045
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.13000925
66	P53_21459846_ChIP-Seq_SAOS-2_Human	1.12348275
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.12314845
68	KLF4_19829295_ChIP-Seq_ESCs_Human	1.12275124
69	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.11602148
70	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.11040110
71	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.07477296
72	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.06966045
73	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.05856006
74	GATA3_26560356_Chip-Seq_TH2_Human	1.04884020
75	PHF8_20622853_ChIP-Seq_HELA_Human	1.04086589
76	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.03409720
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.02643435
78	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02519022
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01797995
80	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01756799
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.00990907
82	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00787540
83	AR_20517297_ChIP-Seq_VCAP_Human	1.00533598
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99905988
85	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.99620499
86	ZNF274_21170338_ChIP-Seq_K562_Hela	0.98553214
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98460985
88	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.98291038
89	GATA3_26560356_Chip-Seq_TH1_Human	0.97606942
90	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.97339572
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96954732
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.95944135
93	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.95282300
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95012127
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94529730
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94434490
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.94250161
98	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.94075385
99	EZH2_22144423_ChIP-Seq_EOC_Human	0.91261534
100	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.90784538

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.40793711
2	MP0003646_muscle_fatigue	8.07258653
3	MP0003878_abnormal_ear_physiology	3.73190657
4	MP0005377_hearing/vestibular/ear_phenot	3.73190657
5	MP0000015_abnormal_ear_pigmentation	3.14672885
6	MP0003698_abnormal_male_reproductive	2.79312836
7	MP0009379_abnormal_foot_pigmentation	2.70534905
8	MP0001929_abnormal_gametogenesis	2.56903968
9	MP0005360_urolithiasis	2.34909306
10	MP0003011_delayed_dark_adaptation	2.31802618
11	MP0005670_abnormal_white_adipose	2.29022524
12	MP0000678_abnormal_parathyroid_gland	2.11965239
13	MP0010307_abnormal_tumor_latency	2.09994381
14	MP0005174_abnormal_tail_pigmentation	2.09699896
15	MP0005075_abnormal_melanosome_morpholog	2.00150182
16	MP0003718_maternal_effect	1.95498852
17	MP0001835_abnormal_antigen_presentation	1.93386760
18	MP0006036_abnormal_mitochondrial_physio	1.87356010
19	MP0001348_abnormal_lacrimal_gland	1.85155209
20	MP0004036_abnormal_muscle_relaxation	1.68167411
21	MP0002161_abnormal_fertility/fecundity	1.61831879
22	MP0001324_abnormal_eye_pigmentation	1.58269578
23	MP0005645_abnormal_hypothalamus_physiol	1.53623491
24	MP0001485_abnormal_pinna_reflex	1.41200183
25	MP0002127_abnormal_cardiovascular_syste	1.36362750
26	MP0005464_abnormal_platelet_physiology	1.25845347
27	MP0003119_abnormal_digestive_system	1.23534902
28	MP0003806_abnormal_nucleotide_metabolis	1.22204955
29	MP0001765_abnormal_ion_homeostasis	1.20871784
30	MP0002132_abnormal_respiratory_system	1.20344081
31	MP0000343_altered_response_to	1.18782149
32	MP0001879_abnormal_lymphatic_vessel	1.12957942
33	MP0004147_increased_porphyrin_level	1.11196243
34	MP0005636_abnormal_mineral_homeostasis	1.08710619
35	MP0004019_abnormal_vitamin_homeostasis	1.07805297
36	MP0008789_abnormal_olfactory_epithelium	1.07605974
37	MP0002249_abnormal_larynx_morphology	1.05252692
38	MP0000566_synostosis	1.03978013
39	MP0002653_abnormal_ependyma_morphology	1.01991359
40	MP0001666_abnormal_nutrient_absorption	1.01279906
41	MP0003943_abnormal_hepatobiliary_system	0.99288516
42	MP0005551_abnormal_eye_electrophysiolog	0.99154865
43	MP0002332_abnormal_exercise_endurance	0.99044201
44	MP0000490_abnormal_crypts_of	0.95219231
45	MP0005379_endocrine/exocrine_gland_phen	0.95158115
46	MP0002210_abnormal_sex_determination	0.94400508
47	MP0005166_decreased_susceptibility_to	0.93818662
48	MP0002095_abnormal_skin_pigmentation	0.91445596
49	MP0000685_abnormal_immune_system	0.89277178
50	MP0010386_abnormal_urinary_bladder	0.88750514
51	MP0001919_abnormal_reproductive_system	0.87619361
52	MP0003763_abnormal_thymus_physiology	0.87599081
53	MP0001756_abnormal_urination	0.84205156
54	MP0001963_abnormal_hearing_physiology	0.83901794
55	MP0002138_abnormal_hepatobiliary_system	0.83408829
56	MP0002234_abnormal_pharynx_morphology	0.82404715
57	MP0000049_abnormal_middle_ear	0.78519679
58	MP0005025_abnormal_response_to	0.78160314
59	MP0003183_abnormal_peptide_metabolism	0.77862494
60	MP0003115_abnormal_respiratory_system	0.77312631
61	MP0000653_abnormal_sex_gland	0.77169981
62	MP0002166_altered_tumor_susceptibility	0.77086761
63	MP0003137_abnormal_impulse_conducting	0.76554762
64	MP0009053_abnormal_anal_canal	0.75927505
65	MP0002102_abnormal_ear_morphology	0.75848538
66	MP0005671_abnormal_response_to	0.75716265
67	MP0000569_abnormal_digit_pigmentation	0.74526233
68	MP0004142_abnormal_muscle_tone	0.74411401
69	MP0001145_abnormal_male_reproductive	0.71403741
70	MP0002282_abnormal_trachea_morphology	0.66596306
71	MP0005397_hematopoietic_system_phenotyp	0.66135033
72	MP0001545_abnormal_hematopoietic_system	0.66135033
73	MP0000026_abnormal_inner_ear	0.64548341
74	MP0009643_abnormal_urine_homeostasis	0.63897311
75	MP0005266_abnormal_metabolism	0.62955313
76	MP0004484_altered_response_of	0.61999143
77	MP0005423_abnormal_somatic_nervous	0.61044759
78	MP0009785_altered_susceptibility_to	0.59908953
79	MP0003699_abnormal_female_reproductive	0.59049338
80	MP0005332_abnormal_amino_acid	0.58629661
81	MP0000230_abnormal_systemic_arterial	0.57273014
82	MP0001873_stomach_inflammation	0.55474351
83	MP0002876_abnormal_thyroid_physiology	0.54277933
84	MP0002822_catalepsy	0.53208532
85	MP0003303_peritoneal_inflammation	0.52938010
86	MP0000534_abnormal_ureter_morphology	0.52915379
87	MP0005165_increased_susceptibility_to	0.52058527
88	MP0000470_abnormal_stomach_morphology	0.51739486
89	MP0005367_renal/urinary_system_phenotyp	0.51428954
90	MP0000516_abnormal_urinary_system	0.51428954
91	MP0005391_vision/eye_phenotype	0.51054129
92	MP0010329_abnormal_lipoprotein_level	0.50930099
93	MP0000371_diluted_coat_color	0.50656884
94	MP0005394_taste/olfaction_phenotype	0.50222593
95	MP0005499_abnormal_olfactory_system	0.50222593
96	MP0005253_abnormal_eye_physiology	0.49722255
97	MP0010368_abnormal_lymphatic_system	0.49665200
98	MP0005535_abnormal_body_temperature	0.49025930
99	MP0003186_abnormal_redox_activity	0.48375406
100	MP0005389_reproductive_system_phenotype	0.48059066

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.01056015
2	Renovascular hypertension (HP:0100817)	5.97790888
3	3-Methylglutaconic aciduria (HP:0003535)	5.62029713
4	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	5.08961363
5	Sensory axonal neuropathy (HP:0003390)	4.97726465
6	Impulsivity (HP:0100710)	4.35650541
7	Tubulointerstitial nephritis (HP:0001970)	4.35624223
8	Resting tremor (HP:0002322)	4.33806895
9	Malnutrition (HP:0004395)	4.09946773
10	Testicular atrophy (HP:0000029)	4.08006791
11	Absent/shortened dynein arms (HP:0200106)	4.07447347
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.07447347
13	Chronic hepatic failure (HP:0100626)	4.05650457
14	Dyschromatopsia (HP:0007641)	3.88408516
15	Paralysis (HP:0003470)	3.48606373
16	Ragged-red muscle fibers (HP:0003200)	3.22493286
17	Abnormal ciliary motility (HP:0012262)	3.21974486
18	Overriding aorta (HP:0002623)	3.17863138
19	Tubulointerstitial abnormality (HP:0001969)	3.13313408
20	Hypoalphalipoproteinemia (HP:0003233)	3.08817212
21	Elfin facies (HP:0004428)	3.08459716
22	Polydipsia (HP:0001959)	3.07092806
23	Abnormal drinking behavior (HP:0030082)	3.07092806
24	Albinism (HP:0001022)	3.04947653
25	Abnormal respiratory motile cilium physiology (HP:0012261)	3.03610672
26	Abnormality of the diencephalon (HP:0010662)	3.02116919
27	Abnormal respiratory epithelium morphology (HP:0012253)	3.00065361
28	Abnormal respiratory motile cilium morphology (HP:0005938)	3.00065361
29	Microvesicular hepatic steatosis (HP:0001414)	2.96494376
30	Infertility (HP:0000789)	2.92932428
31	Cone-rod dystrophy (HP:0000548)	2.86324313
32	Increased purine levels (HP:0004368)	2.83981997
33	Hyperuricemia (HP:0002149)	2.83981997
34	Menstrual irregularities (HP:0000858)	2.82935561
35	Acute necrotizing encephalopathy (HP:0006965)	2.73248971
36	Attenuation of retinal blood vessels (HP:0007843)	2.69121494
37	Insulin-resistant diabetes mellitus (HP:0000831)	2.68163101
38	Subcapsular cataract (HP:0000523)	2.68005130
39	Enlarged epiphyses (HP:0010580)	2.63326416
40	Hyperacusis (HP:0010780)	2.61139208
41	Amblyopia (HP:0000646)	2.60769786
42	Abnormal biliary tract physiology (HP:0012439)	2.60237869
43	Bile duct proliferation (HP:0001408)	2.60237869
44	Abnormality of the costochondral junction (HP:0000919)	2.58765710
45	Tubular atrophy (HP:0000092)	2.51858804
46	Abnormal urine output (HP:0012590)	2.49327807
47	Hypergonadotropic hypogonadism (HP:0000815)	2.43919316
48	Flat cornea (HP:0007720)	2.42235655
49	Progressive sensorineural hearing impairment (HP:0000408)	2.40824957
50	Asymmetric septal hypertrophy (HP:0001670)	2.39903880
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38930138
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.38372365
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.34942978
54	Generalized aminoaciduria (HP:0002909)	2.34288291
55	Nasal polyposis (HP:0100582)	2.33656837
56	Alacrima (HP:0000522)	2.32853678
57	Glycosuria (HP:0003076)	2.32468663
58	Abnormality of urine glucose concentration (HP:0011016)	2.32468663
59	Abnormality of the nasal mucosa (HP:0000433)	2.32154141
60	Polyuria (HP:0000103)	2.29952296
61	Progressive hearing impairment (HP:0001730)	2.28926457
62	Renal duplication (HP:0000075)	2.28270959
63	Tubulointerstitial fibrosis (HP:0005576)	2.24418371
64	Abnormality of purine metabolism (HP:0004352)	2.21931446
65	Abnormality of renal excretion (HP:0011036)	2.17079476
66	Ankle contracture (HP:0006466)	2.15757916
67	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.14180940
68	Gastrointestinal dysmotility (HP:0002579)	2.10291193
69	Progressive macrocephaly (HP:0004481)	2.09544515
70	Portal hypertension (HP:0001409)	2.09059820
71	Abnormality of the lower motor neuron (HP:0002366)	2.09019969
72	Recurrent pneumonia (HP:0006532)	2.08557302
73	Acute encephalopathy (HP:0006846)	2.07756295
74	Congenital stationary night blindness (HP:0007642)	2.06057545
75	Myokymia (HP:0002411)	2.04753068
76	Potter facies (HP:0002009)	2.02536251
77	Facial shape deformation (HP:0011334)	2.02536251
78	Iris hypopigmentation (HP:0007730)	1.99925245
79	Median cleft lip (HP:0000161)	1.99381155
80	Premature ovarian failure (HP:0008209)	1.98581533
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96536109
82	Increased CSF lactate (HP:0002490)	1.95868970
83	Rhinitis (HP:0012384)	1.95493406
84	Decreased central vision (HP:0007663)	1.95057538
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.93942715
86	Renal Fanconi syndrome (HP:0001994)	1.92593636
87	Megalocornea (HP:0000485)	1.91313570
88	Abnormality of the hepatic vasculature (HP:0006707)	1.91215461
89	Nephritis (HP:0000123)	1.89983021
90	Nephronophthisis (HP:0000090)	1.89560340
91	Tetraplegia (HP:0002445)	1.89169876
92	Insomnia (HP:0100785)	1.87551421
93	Impaired proprioception (HP:0010831)	1.86371060
94	Abnormality of the renal cortex (HP:0011035)	1.85705696
95	Ocular albinism (HP:0001107)	1.85469950
96	Mitochondrial inheritance (HP:0001427)	1.84355075
97	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.82781696
98	Thin bony cortex (HP:0002753)	1.81473566
99	Stage 5 chronic kidney disease (HP:0003774)	1.80748615
100	Abnormality of midbrain morphology (HP:0002418)	1.79619835

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	7.28992526
2	CDK8	5.06502537
3	PLK4	4.29719149
4	CDC42BPA	4.02441478
5	MAP4K2	3.73005951
6	TESK1	3.62388156
7	BRSK1	3.26706024
8	CAMKK2	2.97539595
9	SRPK1	2.86893707
10	MAP4K1	2.44095991
11	INSRR	2.18480577
12	DDR2	2.18474982
13	MST4	2.01324106
14	CLK1	1.88929685
15	MAP3K11	1.83087124
16	TIE1	1.80433483
17	TRIB3	1.68340214
18	BLK	1.67974808
19	CAMK1G	1.60891560
20	CAMKK1	1.47752788
21	ACVR1B	1.39805303
22	CAMK1D	1.36964795
23	IRAK4	1.28561500
24	ADRBK2	1.27568996
25	MELK	1.18701404
26	KDR	1.18079710
27	MAPK15	1.16407730
28	MAPK11	1.09140370
29	ZAP70	1.02167919
30	PLK2	1.01360107
31	PKN2	1.00963413
32	BMPR1B	0.98876876
33	PDPK1	0.96972067
34	MAPKAPK2	0.93931862
35	TXK	0.92735955
36	BRSK2	0.92435114
37	PRKG2	0.90380409
38	PTK6	0.88488585
39	ROCK2	0.82864946
40	PTK2B	0.80890732
41	CAMK1	0.80008269
42	ROCK1	0.77523932
43	MST1R	0.75626843
44	GRK1	0.73968100
45	RIPK4	0.73939569
46	TNK2	0.73732385
47	TGFBR1	0.72742384
48	PIK3CG	0.64535203
49	PNCK	0.63889404
50	MATK	0.61405012
51	AURKA	0.58811061
52	CAMK4	0.57133941
53	CDK4	0.55867950
54	ABL2	0.53769428
55	DYRK1B	0.53150527
56	PDK1	0.53128091
57	MYLK	0.52473200
58	DAPK3	0.51588795
59	TESK2	0.50698564
60	CDK7	0.50098151
61	KIT	0.42840243
62	CHEK1	0.40300937
63	ILK	0.39506825
64	STK38	0.39085209
65	PAK1	0.38097195
66	BMPR2	0.34922961
67	PRKG1	0.34873058
68	SYK	0.32349780
69	EIF2AK3	0.32243389
70	DYRK2	0.31585962
71	PRKD2	0.31333596
72	JAK3	0.30462724
73	TLK1	0.29042492
74	MAP2K2	0.27986270
75	MAP3K1	0.27251836
76	NME2	0.26199028
77	STK38L	0.24184380
78	STK39	0.24106283
79	MAPKAPK3	0.23526384
80	CSNK2A2	0.23254411
81	PINK1	0.22855136
82	DAPK2	0.22567057
83	OXSR1	0.21585110
84	MUSK	0.21508827
85	RPS6KA5	0.20173700
86	LYN	0.19343248
87	FGR	0.19213855
88	BTK	0.18200723
89	CSNK2A1	0.18080832
90	RPS6KA1	0.17511415
91	NEK2	0.16714201
92	CSNK1D	0.15070560
93	EPHB2	0.14564044
94	NEK1	0.14416416
95	MAP3K12	0.14347942
96	PRKCQ	0.14101231
97	BRD4	0.12012207
98	PRKCB	0.11742195
99	PASK	0.11367414
100	PRKAA2	0.10184042

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	3.69417686
2	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.57707675
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.53411721
4	Sulfur relay system_Homo sapiens_hsa04122	3.30067474
5	Type I diabetes mellitus_Homo sapiens_hsa04940	3.08073757
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.06051799
7	Ribosome_Homo sapiens_hsa03010	2.85549997
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.75791937
9	Asthma_Homo sapiens_hsa05310	2.69198276
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.65351341
11	Parkinsons disease_Homo sapiens_hsa05012	2.58738253
12	Fat digestion and absorption_Homo sapiens_hsa04975	2.17118814
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.06969297
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.00830315
15	Viral myocarditis_Homo sapiens_hsa05416	1.95320472
16	Huntingtons disease_Homo sapiens_hsa05016	1.92945783
17	Regulation of autophagy_Homo sapiens_hsa04140	1.83596298
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.83540419
19	Olfactory transduction_Homo sapiens_hsa04740	1.80195565
20	Protein export_Homo sapiens_hsa03060	1.65004252
21	Legionellosis_Homo sapiens_hsa05134	1.63222305
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59799028
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53643222
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41142816
25	Alzheimers disease_Homo sapiens_hsa05010	1.38446966
26	RNA polymerase_Homo sapiens_hsa03020	1.35526563
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.33488086
28	Sulfur metabolism_Homo sapiens_hsa00920	1.33288470
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20698342
30	Fatty acid degradation_Homo sapiens_hsa00071	1.20065182
31	Glutathione metabolism_Homo sapiens_hsa00480	1.14039922
32	Proteasome_Homo sapiens_hsa03050	1.13658075
33	RNA degradation_Homo sapiens_hsa03018	1.13256888
34	Butanoate metabolism_Homo sapiens_hsa00650	1.12243304
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08890798
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05710764
37	Retinol metabolism_Homo sapiens_hsa00830	1.03763298
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.99617301
39	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98709110
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.97102644
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90993657
42	Renin-angiotensin system_Homo sapiens_hsa04614	0.89826779
43	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89461343
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89288679
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88798370
46	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.84525855
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.83951773
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82607967
49	Taste transduction_Homo sapiens_hsa04742	0.81154729
50	Spliceosome_Homo sapiens_hsa03040	0.79507041
51	Leishmaniasis_Homo sapiens_hsa05140	0.78616032
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76752802
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.75221063
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73828856
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70318940
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68896406
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68836059
58	Histidine metabolism_Homo sapiens_hsa00340	0.66534270
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66328349
60	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.65356281
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59918780
62	RNA transport_Homo sapiens_hsa03013	0.58654514
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57101799
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56792586
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.56123046
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54180502
67	Mineral absorption_Homo sapiens_hsa04978	0.53356313
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52672809
69	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.51945583
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.50475350
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.50260948
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49654981
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47776649
74	Pancreatic secretion_Homo sapiens_hsa04972	0.46677158
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46048615
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45994736
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.45545935
78	Purine metabolism_Homo sapiens_hsa00230	0.44643829
79	Metabolic pathways_Homo sapiens_hsa01100	0.44284731
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42240455
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.39782874
82	Salivary secretion_Homo sapiens_hsa04970	0.39710707
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39244734
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38830385
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37606425
86	Bile secretion_Homo sapiens_hsa04976	0.36742038
87	Phototransduction_Homo sapiens_hsa04744	0.34495164
88	Toxoplasmosis_Homo sapiens_hsa05145	0.32936021
89	Influenza A_Homo sapiens_hsa05164	0.32753394
90	Malaria_Homo sapiens_hsa05144	0.32351773
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32148929
92	Renin secretion_Homo sapiens_hsa04924	0.31054239
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.30164542
94	Caffeine metabolism_Homo sapiens_hsa00232	0.30058610
95	Cell cycle_Homo sapiens_hsa04110	0.29385040
96	Basal transcription factors_Homo sapiens_hsa03022	0.29311288
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27945940
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.27553501
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.27498488
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.25246061

RPL23AP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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