ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.45850798
2	ATP synthesis coupled proton transport (GO:0015986)	4.95988796
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.95988796
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.95699361
5	ribosomal small subunit assembly (GO:0000028)	4.87131074
6	DNA deamination (GO:0045006)	4.83057077
7	viral transcription (GO:0019083)	4.75745936
8	chaperone-mediated protein transport (GO:0072321)	4.75393788
9	translational termination (GO:0006415)	4.53976433
10	respiratory electron transport chain (GO:0022904)	4.49962384
11	electron transport chain (GO:0022900)	4.47678940
12	proteasome assembly (GO:0043248)	4.30793158
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.27723706
14	cotranslational protein targeting to membrane (GO:0006613)	4.16473715
15	protein targeting to ER (GO:0045047)	4.16125808
16	translational elongation (GO:0006414)	4.13780865
17	protein localization to endoplasmic reticulum (GO:0070972)	3.99461643
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.93679184
19	maturation of SSU-rRNA (GO:0030490)	3.85564912
20	protein complex biogenesis (GO:0070271)	3.83030187
21	regulation of B cell receptor signaling pathway (GO:0050855)	3.72178977
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.62397106
23	NADH dehydrogenase complex assembly (GO:0010257)	3.62397106
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.62397106
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61175354
26	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.56276877
27	aggressive behavior (GO:0002118)	3.55558830
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.52282065
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.52282065
30	indolalkylamine metabolic process (GO:0006586)	3.52149493
31	ribosomal large subunit biogenesis (GO:0042273)	3.51852074
32	indole-containing compound catabolic process (GO:0042436)	3.50504868
33	indolalkylamine catabolic process (GO:0046218)	3.50504868
34	tryptophan catabolic process (GO:0006569)	3.50504868
35	tryptophan metabolic process (GO:0006568)	3.49272386
36	positive regulation of protein homodimerization activity (GO:0090073)	3.40993978
37	viral life cycle (GO:0019058)	3.39558003
38	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.30168119
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.28018113
40	cellular protein complex disassembly (GO:0043624)	3.27851570
41	platelet dense granule organization (GO:0060155)	3.24251230
42	regulation of mitotic spindle checkpoint (GO:1903504)	3.22358687
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.22358687
44	kynurenine metabolic process (GO:0070189)	3.20162662
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.18903729
46	maturation of 5.8S rRNA (GO:0000460)	3.14807093
47	regulation of cilium movement (GO:0003352)	3.13985174
48	piRNA metabolic process (GO:0034587)	3.13249013
49	immunoglobulin mediated immune response (GO:0016064)	3.12917571
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.12619665
51	translation (GO:0006412)	3.06370442
52	translational initiation (GO:0006413)	3.03282245
53	termination of RNA polymerase III transcription (GO:0006386)	3.03259788
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03259788
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.97272801
56	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.96853107
57	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.94020223
58	positive regulation of T cell cytokine production (GO:0002726)	2.92432633
59	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.91787649
60	regulation of oxidative phosphorylation (GO:0002082)	2.91245766
61	auditory receptor cell stereocilium organization (GO:0060088)	2.90950186
62	hydrogen ion transmembrane transport (GO:1902600)	2.89408237
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.87664841
64	positive regulation of prostaglandin secretion (GO:0032308)	2.87510069
65	cytidine deamination (GO:0009972)	2.86939072
66	cytidine metabolic process (GO:0046087)	2.86939072
67	cytidine catabolic process (GO:0006216)	2.86939072
68	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	2.84438548
69	hydrogen transport (GO:0006818)	2.83472296
70	proton transport (GO:0015992)	2.81935107
71	ubiquinone biosynthetic process (GO:0006744)	2.81291923
72	response to pheromone (GO:0019236)	2.76698756
73	protein targeting to membrane (GO:0006612)	2.76167598
74	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.75513635
75	ribosomal small subunit biogenesis (GO:0042274)	2.74091780
76	peptidyl-histidine modification (GO:0018202)	2.68124455
77	T cell receptor signaling pathway (GO:0050852)	2.65017066
78	oxidative phosphorylation (GO:0006119)	2.64062711
79	actin nucleation (GO:0045010)	2.63568198
80	GPI anchor biosynthetic process (GO:0006506)	2.62012693
81	grooming behavior (GO:0007625)	2.61993361
82	positive thymic T cell selection (GO:0045059)	2.59372269
83	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.58946049
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.58682989
85	ATP biosynthetic process (GO:0006754)	2.58321168
86	photoreceptor cell maintenance (GO:0045494)	2.54886191
87	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.53716901
88	protein complex disassembly (GO:0043241)	2.53496886
89	female mating behavior (GO:0060180)	2.52572036
90	respiratory chain complex IV assembly (GO:0008535)	2.51949036
91	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.49447871
92	xenobiotic catabolic process (GO:0042178)	2.48380587
93	negative T cell selection (GO:0043383)	2.47619090
94	macromolecular complex disassembly (GO:0032984)	2.47617519
95	regulation of cellular respiration (GO:0043457)	2.46896106
96	GPI anchor metabolic process (GO:0006505)	2.45835695
97	regulation of T cell mediated cytotoxicity (GO:0001914)	2.44347978
98	regulation of female receptivity (GO:0045924)	2.43642083
99	benzene-containing compound metabolic process (GO:0042537)	2.43466041
100	cytochrome complex assembly (GO:0017004)	2.42666970

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.08386675
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.96578549
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.60713566
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.13030229
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.11711255
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09365812
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.93845108
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84369628
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.81675500
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50806326
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38194633
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.36261168
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.34350492
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24385235
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.23382880
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21467854
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12314864
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.02083286
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98313859
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.71309141
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70876360
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.70099314
23	AR_20517297_ChIP-Seq_VCAP_Human	1.66833679
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.62450741
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62394585
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58552187
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.57237132
28	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.54491310
29	GATA3_26560356_Chip-Seq_TH2_Human	1.52411606
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51548696
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50706081
32	VDR_22108803_ChIP-Seq_LS180_Human	1.50090172
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48503165
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47129529
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44981883
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.43149204
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39930053
38	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.37126896
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.33770106
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32612103
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32612103
42	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31582636
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.29535419
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.26320837
45	ERG_20517297_ChIP-Seq_VCAP_Human	1.24880147
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24541800
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.23685806
48	FUS_26573619_Chip-Seq_HEK293_Human	1.23465710
49	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.22800386
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22246820
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22246820
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21936854
53	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.20778235
54	EWS_26573619_Chip-Seq_HEK293_Human	1.20669752
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20430145
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18263425
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17868435
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.17081196
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16823809
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15129247
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14474472
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.13341297
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13185078
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12813053
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11308505
66	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.10786726
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10246304
68	TTF2_22483619_ChIP-Seq_HELA_Human	1.09832235
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.07841498
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07773286
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.07773286
72	MYB_26560356_Chip-Seq_TH2_Human	1.07582254
73	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07472238
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06592651
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06069411
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05663243
77	SPI1_23547873_ChIP-Seq_NB4_Human	1.05000523
78	E2F1_20622854_ChIP-Seq_HELA_Human	1.04360281
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.01916572
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01876695
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01786362
82	SOX2_21211035_ChIP-Seq_LN229_Human	1.01725325
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01573552
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00565375
85	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98813541
86	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.98498548
87	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.98409128
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98048830
89	EZH2_22144423_ChIP-Seq_EOC_Human	0.96935413
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96295446
91	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94677819
92	ZNF263_19887448_ChIP-Seq_K562_Human	0.94086007
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93279663
94	GATA3_27048872_Chip-Seq_THYMUS_Human	0.93195679
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92731246
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92387032
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.90859022
98	P300_19829295_ChIP-Seq_ESCs_Human	0.90736264
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89834123
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89414005

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.64930515
2	MP0001835_abnormal_antigen_presentation	3.28014376
3	MP0002138_abnormal_hepatobiliary_system	3.25487272
4	MP0009379_abnormal_foot_pigmentation	2.96642926
5	MP0005671_abnormal_response_to	2.90070051
6	MP0001986_abnormal_taste_sensitivity	2.80186554
7	MP0005646_abnormal_pituitary_gland	2.47061373
8	MP0003724_increased_susceptibility_to	2.23095580
9	MP0002139_abnormal_hepatobiliary_system	2.22994989
10	MP0003252_abnormal_bile_duct	2.13276868
11	MP0003787_abnormal_imprinting	2.06014685
12	MP0008875_abnormal_xenobiotic_pharmacok	2.01601843
13	MP0009785_altered_susceptibility_to	2.00094167
14	MP0005084_abnormal_gallbladder_morpholo	1.99256337
15	MP0006292_abnormal_olfactory_placode	1.96605464
16	MP0003878_abnormal_ear_physiology	1.85164788
17	MP0005377_hearing/vestibular/ear_phenot	1.85164788
18	MP0001968_abnormal_touch/_nociception	1.84590101
19	MP0006072_abnormal_retinal_apoptosis	1.84342597
20	MP0004147_increased_porphyrin_level	1.80580898
21	MP0002837_dystrophic_cardiac_calcinosis	1.78826003
22	MP0001984_abnormal_olfaction	1.75214628
23	MP0006276_abnormal_autonomic_nervous	1.73698271
24	MP0001905_abnormal_dopamine_level	1.73386322
25	MP0002148_abnormal_hypersensitivity_rea	1.67149167
26	MP0002653_abnormal_ependyma_morphology	1.61747205
27	MP0001800_abnormal_humoral_immune	1.60394583
28	MP0002876_abnormal_thyroid_physiology	1.57270913
29	MP0008789_abnormal_olfactory_epithelium	1.56447437
30	MP0003195_calcinosis	1.55995855
31	MP0004145_abnormal_muscle_electrophysio	1.55302551
32	MP0002452_abnormal_antigen_presenting	1.53180909
33	MP0003866_abnormal_defecation	1.51093589
34	MP0002723_abnormal_immune_serum	1.47048766
35	MP0003880_abnormal_central_pattern	1.47047242
36	MP0008872_abnormal_physiological_respon	1.45850886
37	MP0001919_abnormal_reproductive_system	1.44786635
38	MP0005551_abnormal_eye_electrophysiolog	1.42711715
39	MP0005410_abnormal_fertilization	1.40466869
40	MP0001819_abnormal_immune_cell	1.39553063
41	MP0001529_abnormal_vocalization	1.34292658
42	MP0002420_abnormal_adaptive_immunity	1.34178304
43	MP0005389_reproductive_system_phenotype	1.33305889
44	MP0006036_abnormal_mitochondrial_physio	1.30632168
45	MP0003646_muscle_fatigue	1.30596341
46	MP0002166_altered_tumor_susceptibility	1.25830549
47	MP0005000_abnormal_immune_tolerance	1.25466047
48	MP0003718_maternal_effect	1.24859138
49	MP0002736_abnormal_nociception_after	1.24806468
50	MP0002009_preneoplasia	1.20812122
51	MP0005085_abnormal_gallbladder_physiolo	1.20638687
52	MP0005387_immune_system_phenotype	1.19353634
53	MP0001790_abnormal_immune_system	1.19353634
54	MP0005670_abnormal_white_adipose	1.17141464
55	MP0004142_abnormal_muscle_tone	1.15082424
56	MP0000230_abnormal_systemic_arterial	1.09340670
57	MP0003763_abnormal_thymus_physiology	1.06129450
58	MP0003045_fibrosis	1.05519080
59	MP0003638_abnormal_response/metabolism_	1.05477263
60	MP0000372_irregular_coat_pigmentation	1.04366434
61	MP0004885_abnormal_endolymph	1.04140932
62	MP0002006_tumorigenesis	1.02716123
63	MP0005503_abnormal_tendon_morphology	0.98344218
64	MP0001970_abnormal_pain_threshold	0.98065356
65	MP0005025_abnormal_response_to	0.96760218
66	MP0001764_abnormal_homeostasis	0.96706806
67	MP0003303_peritoneal_inflammation	0.96169918
68	MP0008877_abnormal_DNA_methylation	0.94629109
69	MP0009053_abnormal_anal_canal	0.94219536
70	MP0001501_abnormal_sleep_pattern	0.94081246
71	MP0005499_abnormal_olfactory_system	0.91228908
72	MP0005394_taste/olfaction_phenotype	0.91228908
73	MP0002419_abnormal_innate_immunity	0.90799594
74	MP0003186_abnormal_redox_activity	0.90623664
75	MP0005636_abnormal_mineral_homeostasis	0.90530713
76	MP0000716_abnormal_immune_system	0.89550540
77	MP0005253_abnormal_eye_physiology	0.89540561
78	MP0008775_abnormal_heart_ventricle	0.89412145
79	MP0001486_abnormal_startle_reflex	0.87868591
80	MP0009764_decreased_sensitivity_to	0.86756426
81	MP0006054_spinal_hemorrhage	0.86501756
82	MP0002102_abnormal_ear_morphology	0.86246995
83	MP0008469_abnormal_protein_level	0.83957205
84	MP0001440_abnormal_grooming_behavior	0.83764242
85	MP0002398_abnormal_bone_marrow	0.83596889
86	MP0002928_abnormal_bile_duct	0.83396238
87	MP0000685_abnormal_immune_system	0.81856983
88	MP0002733_abnormal_thermal_nociception	0.81407959
89	MP0002272_abnormal_nervous_system	0.81405178
90	MP0003011_delayed_dark_adaptation	0.79498873
91	MP0001845_abnormal_inflammatory_respons	0.77197772
92	MP0009643_abnormal_urine_homeostasis	0.74848713
93	MP0005332_abnormal_amino_acid	0.74534427
94	MP0008058_abnormal_DNA_repair	0.73635729
95	MP0009697_abnormal_copulation	0.71448361
96	MP0003879_abnormal_hair_cell	0.71336974
97	MP0010155_abnormal_intestine_physiology	0.70536858
98	MP0010329_abnormal_lipoprotein_level	0.70024757
99	MP0002429_abnormal_blood_cell	0.69897310
100	MP0001661_extended_life_span	0.69510644

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.73666718
2	Acute necrotizing encephalopathy (HP:0006965)	4.54065121
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35632744
4	Mitochondrial inheritance (HP:0001427)	4.28970114
5	Renal Fanconi syndrome (HP:0001994)	3.91484613
6	Progressive macrocephaly (HP:0004481)	3.83458067
7	Acute encephalopathy (HP:0006846)	3.74688038
8	Increased CSF lactate (HP:0002490)	3.70279650
9	Hepatocellular necrosis (HP:0001404)	3.59910574
10	Increased hepatocellular lipid droplets (HP:0006565)	3.59859200
11	Increased intramyocellular lipid droplets (HP:0012240)	3.39069200
12	Type II lissencephaly (HP:0007260)	3.35144253
13	Lipid accumulation in hepatocytes (HP:0006561)	3.24226081
14	Hypoproteinemia (HP:0003075)	3.22872108
15	Hepatic necrosis (HP:0002605)	3.12303721
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.09945176
17	Pancreatic cysts (HP:0001737)	3.06112437
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.01886879
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.01886879
20	Congenital, generalized hypertrichosis (HP:0004540)	2.91354284
21	Type 2 muscle fiber atrophy (HP:0003554)	2.86361367
22	Pancytopenia (HP:0001876)	2.84966094
23	Exertional dyspnea (HP:0002875)	2.84311110
24	Cerebral edema (HP:0002181)	2.77480424
25	Increased muscle lipid content (HP:0009058)	2.75994602
26	Increased serum lactate (HP:0002151)	2.69898541
27	Abnormality of the prostate (HP:0008775)	2.69251362
28	Spontaneous abortion (HP:0005268)	2.60364136
29	IgG deficiency (HP:0004315)	2.52760959
30	Thrombocytosis (HP:0001894)	2.48667901
31	Reduced antithrombin III activity (HP:0001976)	2.48019601
32	Abnormal number of erythroid precursors (HP:0012131)	2.46529677
33	Abnormality of renal resorption (HP:0011038)	2.45924643
34	Abnormality of cells of the erythroid lineage (HP:0012130)	2.44296850
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.44254022
36	Lactic acidosis (HP:0003128)	2.43144382
37	Optic disc pallor (HP:0000543)	2.41813862
38	3-Methylglutaconic aciduria (HP:0003535)	2.37449805
39	Entropion (HP:0000621)	2.37124092
40	Hypothermia (HP:0002045)	2.36774089
41	Elevated erythrocyte sedimentation rate (HP:0003565)	2.35894289
42	Leukodystrophy (HP:0002415)	2.34868012
43	Respiratory failure (HP:0002878)	2.34678535
44	Glycosuria (HP:0003076)	2.33907194
45	Abnormality of urine glucose concentration (HP:0011016)	2.33907194
46	Muscle fiber atrophy (HP:0100295)	2.33045335
47	Generalized aminoaciduria (HP:0002909)	2.32479351
48	Type I transferrin isoform profile (HP:0003642)	2.24499537
49	Polyuria (HP:0000103)	2.23791440
50	Prostate neoplasm (HP:0100787)	2.23449254
51	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.22970328
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21274735
53	Abnormality of the renal cortex (HP:0011035)	2.20381646
54	Chronic diarrhea (HP:0002028)	2.17072675
55	Exercise intolerance (HP:0003546)	2.16684308
56	Medial flaring of the eyebrow (HP:0010747)	2.14496463
57	Dry hair (HP:0011359)	2.12130278
58	Abnormal drinking behavior (HP:0030082)	2.11198607
59	Polydipsia (HP:0001959)	2.11198607
60	Amaurosis fugax (HP:0100576)	2.07520466
61	Hypomagnesemia (HP:0002917)	2.07267266
62	Constricted visual fields (HP:0001133)	2.06128491
63	Congenital stationary night blindness (HP:0007642)	2.05682044
64	Abnormality of DNA repair (HP:0003254)	2.05218999
65	Abnormality of midbrain morphology (HP:0002418)	2.01644827
66	Molar tooth sign on MRI (HP:0002419)	2.01644827
67	Stomach cancer (HP:0012126)	1.99029719
68	Abnormality of magnesium homeostasis (HP:0004921)	1.97061736
69	Macrocytic anemia (HP:0001972)	1.95212922
70	Attenuation of retinal blood vessels (HP:0007843)	1.94998963
71	Abnormal biliary tract physiology (HP:0012439)	1.93466071
72	Bile duct proliferation (HP:0001408)	1.93466071
73	Abnormality of the renal medulla (HP:0100957)	1.91904865
74	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91799863
75	Muscle hypertrophy of the lower extremities (HP:0008968)	1.91308513
76	Fused cervical vertebrae (HP:0002949)	1.91093199
77	Reticulocytopenia (HP:0001896)	1.90948179
78	Retinal dysplasia (HP:0007973)	1.90736575
79	Oral leukoplakia (HP:0002745)	1.89943337
80	Poikiloderma (HP:0001029)	1.88948935
81	Renal cortical cysts (HP:0000803)	1.88915548
82	Concave nail (HP:0001598)	1.88558483
83	Hyperglycinuria (HP:0003108)	1.87410610
84	Lethargy (HP:0001254)	1.85471985
85	Nephronophthisis (HP:0000090)	1.84959937
86	Cleft eyelid (HP:0000625)	1.84787184
87	Abnormal urine output (HP:0012590)	1.84210449
88	Congenital primary aphakia (HP:0007707)	1.81979989
89	Abolished electroretinogram (ERG) (HP:0000550)	1.81698418
90	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81657300
91	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.81637903
92	Abnormal glycosylation (HP:0012345)	1.81062248
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81062248
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.81062248
95	Abnormal protein glycosylation (HP:0012346)	1.81062248
96	Pancreatic fibrosis (HP:0100732)	1.80736616
97	Abnormality of the costochondral junction (HP:0000919)	1.79604926
98	IgM deficiency (HP:0002850)	1.79468384
99	Hyperglycinemia (HP:0002154)	1.78506210
100	Amniotic constriction ring (HP:0009775)	1.74012725

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.09836979
2	ADRBK2	2.94948180
3	MAP3K12	2.75677804
4	TLK1	2.75474324
5	TEC	2.69298380
6	MAP4K1	2.52808841
7	KDR	2.42265570
8	MAP4K2	2.36389594
9	ZAK	2.27661432
10	BMPR2	2.27511405
11	FRK	2.21251086
12	STK16	2.19219603
13	MST4	2.12812286
14	TXK	2.10814051
15	ITK	1.97837390
16	NUAK1	1.87484030
17	MYLK	1.87371273
18	SCYL2	1.73997783
19	CSF1R	1.71816170
20	CDK19	1.70174803
21	SYK	1.68258755
22	BTK	1.64185226
23	MAPKAPK3	1.61132142
24	GRK1	1.58850274
25	GRK6	1.54131629
26	RIPK4	1.50026727
27	MAP3K13	1.40206435
28	IKBKB	1.39557440
29	NME2	1.30206049
30	FLT3	1.25551116
31	PHKG1	1.25419109
32	PHKG2	1.25419109
33	KIT	1.22951150
34	TIE1	1.20278952
35	PINK1	1.15390652
36	FES	1.13625294
37	LYN	1.12699823
38	RPS6KA5	1.08206827
39	LIMK1	1.07857980
40	VRK2	1.07287703
41	DAPK1	0.97362290
42	PRKCQ	0.91829521
43	INSRR	0.90637966
44	EIF2AK3	0.90434149
45	SRPK1	0.88966319
46	OXSR1	0.87633944
47	LCK	0.86837327
48	ZAP70	0.86595130
49	TNK2	0.86430441
50	ERBB3	0.85037649
51	MAP2K2	0.84304186
52	IGF1R	0.83019212
53	WNK4	0.79803280
54	ABL1	0.77318587
55	OBSCN	0.77088095
56	ADRBK1	0.74691315
57	PIK3CA	0.74588008
58	CDK3	0.73978229
59	PIM1	0.71579794
60	CDK8	0.71307223
61	MAP3K14	0.70884428
62	TRPM7	0.70125835
63	BCKDK	0.68769833
64	MAP3K7	0.68001261
65	CHUK	0.67988889
66	BMPR1B	0.67057711
67	TESK1	0.66489646
68	PRKCE	0.65289489
69	ILK	0.65111321
70	MAP2K6	0.64509096
71	AURKB	0.63535446
72	MAP3K11	0.62568277
73	PLK2	0.59788789
74	PIM2	0.57965475
75	MAP3K5	0.57511329
76	CSNK1G3	0.57465643
77	PIK3CG	0.56336444
78	PASK	0.54676767
79	CHEK2	0.52954216
80	DAPK3	0.52211162
81	EGFR	0.52118344
82	RPS6KA4	0.50323526
83	PRKACA	0.50013759
84	HCK	0.49297761
85	PRKG2	0.47203862
86	PRKG1	0.47063667
87	PDK2	0.46108402
88	WNK3	0.45945426
89	PTK2B	0.45748512
90	CSNK2A2	0.45718970
91	CSNK2A1	0.45142655
92	PRKCA	0.45084735
93	CSNK1G1	0.44152079
94	CAMK2A	0.42957181
95	CSNK1G2	0.41354901
96	IKBKE	0.38791826
97	MAPK7	0.38693593
98	TESK2	0.38406673
99	MAPKAPK5	0.38165998
100	CSNK1A1	0.37230017

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.14071066
2	Ribosome_Homo sapiens_hsa03010	3.72170033
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62875196
4	Allograft rejection_Homo sapiens_hsa05330	3.43610022
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.29973772
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.22872676
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.03183936
8	Parkinsons disease_Homo sapiens_hsa05012	2.95793285
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.75359836
10	Proteasome_Homo sapiens_hsa03050	2.48843054
11	Protein export_Homo sapiens_hsa03060	2.34479202
12	Antigen processing and presentation_Homo sapiens_hsa04612	1.96451427
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95546090
14	Alzheimers disease_Homo sapiens_hsa05010	1.91425701
15	Huntingtons disease_Homo sapiens_hsa05016	1.90289163
16	RNA polymerase_Homo sapiens_hsa03020	1.89085677
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.88472374
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.83940579
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.75634735
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.71324116
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70774353
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.56070790
23	Viral myocarditis_Homo sapiens_hsa05416	1.50958267
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40086627
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36563447
26	Leishmaniasis_Homo sapiens_hsa05140	1.33274026
27	Regulation of autophagy_Homo sapiens_hsa04140	1.28760535
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.28132558
29	DNA replication_Homo sapiens_hsa03030	1.23005801
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.14452589
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08224150
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07737124
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06199317
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03863592
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01047170
36	Base excision repair_Homo sapiens_hsa03410	0.99252027
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98677646
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97648157
39	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94486408
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.89840366
41	One carbon pool by folate_Homo sapiens_hsa00670	0.89341746
42	Phototransduction_Homo sapiens_hsa04744	0.88830955
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87358519
44	Olfactory transduction_Homo sapiens_hsa04740	0.87080802
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.86338667
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85572886
47	RNA degradation_Homo sapiens_hsa03018	0.84359415
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81764075
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.81511299
50	Homologous recombination_Homo sapiens_hsa03440	0.81302057
51	Mismatch repair_Homo sapiens_hsa03430	0.79654726
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75757129
53	Purine metabolism_Homo sapiens_hsa00230	0.72910778
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.72839801
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72030842
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71611958
57	Herpes simplex infection_Homo sapiens_hsa05168	0.69640350
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64931882
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.64275891
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.63051962
61	Caffeine metabolism_Homo sapiens_hsa00232	0.62715789
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61739620
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60662839
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59444504
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59086543
66	Spliceosome_Homo sapiens_hsa03040	0.58618466
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57848449
68	Sulfur relay system_Homo sapiens_hsa04122	0.57721322
69	Taste transduction_Homo sapiens_hsa04742	0.56205105
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55049514
71	Phagosome_Homo sapiens_hsa04145	0.50625737
72	Retinol metabolism_Homo sapiens_hsa00830	0.49254231
73	Metabolic pathways_Homo sapiens_hsa01100	0.48141425
74	Butanoate metabolism_Homo sapiens_hsa00650	0.46105766
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44501169
76	Peroxisome_Homo sapiens_hsa04146	0.39803625
77	Glutathione metabolism_Homo sapiens_hsa00480	0.39457625
78	Toxoplasmosis_Homo sapiens_hsa05145	0.38310803
79	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37012337
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36044505
81	Basal transcription factors_Homo sapiens_hsa03022	0.36030379
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35822296
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.35430085
84	Salivary secretion_Homo sapiens_hsa04970	0.35367119
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.34069294
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33317395
87	RNA transport_Homo sapiens_hsa03013	0.30645497
88	Pertussis_Homo sapiens_hsa05133	0.29767871
89	Influenza A_Homo sapiens_hsa05164	0.28673677
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26877191
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23978763
92	Morphine addiction_Homo sapiens_hsa05032	0.23843645
93	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.23297083
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23287455
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22428917
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.21334855
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21209327
98	Folate biosynthesis_Homo sapiens_hsa00790	0.20798475
99	Tuberculosis_Homo sapiens_hsa05152	0.20466963
100	African trypanosomiasis_Homo sapiens_hsa05143	0.19214100

RPL23AP28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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