RPL23AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.91220603
2cytidine metabolic process (GO:0046087)6.56096288
3cytidine catabolic process (GO:0006216)6.56096288
4cytidine deamination (GO:0009972)6.56096288
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.43758970
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.86016151
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.61250153
8regulation of natural killer cell mediated immunity (GO:0002715)5.31003798
9regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.31003798
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.09116438
11positive regulation of natural killer cell mediated immunity (GO:0002717)5.07355530
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89416043
13ATP synthesis coupled proton transport (GO:0015986)4.68279535
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68279535
15neurofilament cytoskeleton organization (GO:0060052)4.67111085
16regulation of regulatory T cell differentiation (GO:0045589)4.58306792
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.53609791
18regulation of leukocyte mediated cytotoxicity (GO:0001910)4.47768327
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.47633691
20regulation of activation of Janus kinase activity (GO:0010533)4.43737604
21chaperone-mediated protein transport (GO:0072321)4.33408070
22glyoxylate metabolic process (GO:0046487)4.25521945
23positive T cell selection (GO:0043368)4.23834167
24positive thymic T cell selection (GO:0045059)4.21196575
25cytolysis (GO:0019835)4.11813986
26regulation of isotype switching to IgG isotypes (GO:0048302)4.02555335
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.95322110
28regulation of cell killing (GO:0031341)3.93063341
29cellular response to interleukin-15 (GO:0071350)3.90014764
30positive regulation of cell killing (GO:0031343)3.88639869
31actin nucleation (GO:0045010)3.87557107
32positive regulation of tolerance induction (GO:0002645)3.86584127
33regulation of T cell tolerance induction (GO:0002664)3.83258999
34positive regulation of T cell mediated cytotoxicity (GO:0001916)3.72296462
35inner mitochondrial membrane organization (GO:0007007)3.68932019
36negative regulation of mast cell activation (GO:0033004)3.64756100
37positive regulation of calcium-mediated signaling (GO:0050850)3.60597550
38natural killer cell activation (GO:0030101)3.53418523
39thymic T cell selection (GO:0045061)3.47957626
40regulation of B cell receptor signaling pathway (GO:0050855)3.45573903
41regulation of T cell mediated cytotoxicity (GO:0001914)3.42830395
42respiratory electron transport chain (GO:0022904)3.37805037
43electron transport chain (GO:0022900)3.35398012
44T cell migration (GO:0072678)3.33413083
45sequestering of actin monomers (GO:0042989)3.33339673
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29674860
47negative T cell selection (GO:0043383)3.27191176
48T cell receptor signaling pathway (GO:0050852)3.26752361
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25060914
50ribosomal small subunit assembly (GO:0000028)3.22503397
51positive regulation of gamma-delta T cell activation (GO:0046645)3.17391653
52mast cell activation (GO:0045576)3.12892178
53pyrimidine nucleoside catabolic process (GO:0046135)3.12803545
54regulation of tolerance induction (GO:0002643)3.12782499
55regulation of T cell receptor signaling pathway (GO:0050856)3.12126862
56male meiosis (GO:0007140)3.10982333
57T cell selection (GO:0045058)3.08029152
58thyroid hormone generation (GO:0006590)3.05685224
59negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.04505056
60regulation of DNA methylation (GO:0044030)3.01674533
61negative regulation of T cell apoptotic process (GO:0070233)2.99345195
62positive regulation of lymphocyte mediated immunity (GO:0002708)2.97281289
63negative regulation of viral genome replication (GO:0045071)2.95977268
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95678490
65negative regulation of telomere maintenance (GO:0032205)2.94750990
66regulation of chronic inflammatory response (GO:0002676)2.93850587
67response to interleukin-15 (GO:0070672)2.93397872
68positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93261492
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.89834098
70regulation of T cell chemotaxis (GO:0010819)2.88644654
71positive regulation of T cell chemotaxis (GO:0010820)2.88644654
72thyroid hormone metabolic process (GO:0042403)2.87812830
73lymphocyte costimulation (GO:0031294)2.87180294
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86834552
75T cell costimulation (GO:0031295)2.86040146
76ATP biosynthetic process (GO:0006754)2.85513748
77negative regulation by host of viral transcription (GO:0043922)2.84592522
78ectoderm development (GO:0007398)2.83595691
79protein neddylation (GO:0045116)2.83215589
80eosinophil chemotaxis (GO:0048245)2.82098060
81cellular defense response (GO:0006968)2.77721625
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75859154
83antigen receptor-mediated signaling pathway (GO:0050851)2.74128089
84positive regulation of interleukin-17 production (GO:0032740)2.73827103
85regulation of interleukin-2 biosynthetic process (GO:0045076)2.70288231
86regulation of gamma-delta T cell differentiation (GO:0045586)2.70279404
87regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67648884
88negative thymic T cell selection (GO:0045060)2.66925137
89protein-cofactor linkage (GO:0018065)2.66873013
90regulation of alpha-beta T cell proliferation (GO:0046640)2.65875180
91piRNA metabolic process (GO:0034587)2.65469809
92regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.65395169
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.64022967
94lymphocyte migration (GO:0072676)2.63612984
95iron-sulfur cluster assembly (GO:0016226)2.62996327
96metallo-sulfur cluster assembly (GO:0031163)2.62996327
97positive regulation of T cell apoptotic process (GO:0070234)2.62676930
98hydrogen ion transmembrane transport (GO:1902600)2.60748168
99positive regulation of T cell mediated immunity (GO:0002711)2.60586203
100eosinophil migration (GO:0072677)2.59104300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11865376
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.95569725
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.82938419
4VDR_22108803_ChIP-Seq_LS180_Human3.53579586
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39319275
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35391478
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05214927
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82007459
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80634449
10IGF1R_20145208_ChIP-Seq_DFB_Human2.75351861
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.58003364
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29297349
13ZNF274_21170338_ChIP-Seq_K562_Hela2.19959995
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19630914
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.07496627
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.01987880
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92784958
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89467631
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88295916
20EZH2_22144423_ChIP-Seq_EOC_Human1.85842945
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.84276943
22MYB_26560356_Chip-Seq_TH2_Human1.83552782
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76684707
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76592534
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.72171661
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65025194
27RUNX_20019798_ChIP-Seq_JUKART_Human1.63648623
28VDR_23849224_ChIP-Seq_CD4+_Human1.62243700
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60122020
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.55912259
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.49844752
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46767878
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43871283
34HTT_18923047_ChIP-ChIP_STHdh_Human1.41991696
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40834002
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40666069
37GATA3_27048872_Chip-Seq_THYMUS_Human1.40492994
38GATA3_26560356_Chip-Seq_TH2_Human1.39574326
39TP53_22573176_ChIP-Seq_HFKS_Human1.39227996
40NANOG_20526341_ChIP-Seq_ESCs_Human1.35143530
41NCOR_22424771_ChIP-Seq_293T_Human1.35023360
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34761910
43IRF1_19129219_ChIP-ChIP_H3396_Human1.31120011
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29247144
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28233388
46CBP_20019798_ChIP-Seq_JUKART_Human1.26568909
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26568909
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.25050473
49MYB_26560356_Chip-Seq_TH1_Human1.24175310
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22856051
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21760924
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21353975
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20566847
54TAF2_19829295_ChIP-Seq_ESCs_Human1.17866128
55FOXP3_21729870_ChIP-Seq_TREG_Human1.17724562
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16993924
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.16802265
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16421343
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15518195
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14939609
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13828929
62GBX2_23144817_ChIP-Seq_PC3_Human1.12029939
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11389324
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.10184563
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10184563
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08374822
67EWS_26573619_Chip-Seq_HEK293_Human1.07808682
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07614433
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06797396
70MYC_19829295_ChIP-Seq_ESCs_Human1.06467052
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05939337
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.05797118
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03298272
74CTCF_20526341_ChIP-Seq_ESCs_Human1.02805762
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02629955
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00880370
77MAF_26560356_Chip-Seq_TH2_Human1.00607277
78AR_20517297_ChIP-Seq_VCAP_Human1.00357127
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99499362
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97910910
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96830730
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96747946
83ELK1_19687146_ChIP-ChIP_HELA_Human0.96733990
84ERG_20517297_ChIP-Seq_VCAP_Human0.96133916
85ERA_21632823_ChIP-Seq_H3396_Human0.96110462
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95145449
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95059027
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.93815071
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.93487572
90BCAT_22108803_ChIP-Seq_LS180_Human0.93277795
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91924490
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.91415365
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.91222666
94SOX2_19829295_ChIP-Seq_ESCs_Human0.91175286
95NANOG_19829295_ChIP-Seq_ESCs_Human0.91175286
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89126170
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.86978089
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86948583
99UTX_26944678_Chip-Seq_JUKART_Human0.86832544
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85284583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.29049377
2MP0008995_early_reproductive_senescence4.13681740
3MP0003763_abnormal_thymus_physiology3.25892474
4MP0003646_muscle_fatigue3.05592871
5MP0001835_abnormal_antigen_presentation2.74295195
6MP0009333_abnormal_splenocyte_physiolog2.69086278
7MP0009785_altered_susceptibility_to2.55269589
8MP0003786_premature_aging2.55084830
9MP0006082_CNS_inflammation2.46662665
10MP0001790_abnormal_immune_system2.31563926
11MP0005387_immune_system_phenotype2.31563926
12MP0002876_abnormal_thyroid_physiology2.29259233
13MP0001873_stomach_inflammation2.13464894
14MP0000685_abnormal_immune_system2.05335735
15MP0008875_abnormal_xenobiotic_pharmacok2.05268450
16MP0005000_abnormal_immune_tolerance2.04799919
17MP0001800_abnormal_humoral_immune2.03893914
18MP0003866_abnormal_defecation1.95403349
19MP0002163_abnormal_gland_morphology1.91937877
20MP0002420_abnormal_adaptive_immunity1.91451185
21MP0005025_abnormal_response_to1.89217480
22MP0002723_abnormal_immune_serum1.87990736
23MP0001819_abnormal_immune_cell1.82452630
24MP0004885_abnormal_endolymph1.80434555
25MP0002837_dystrophic_cardiac_calcinosis1.79844601
26MP0000372_irregular_coat_pigmentation1.74433805
27MP0002166_altered_tumor_susceptibility1.69363878
28MP0008872_abnormal_physiological_respon1.69144621
29MP0002102_abnormal_ear_morphology1.65714359
30MP0002277_abnormal_respiratory_mucosa1.63069403
31MP0005645_abnormal_hypothalamus_physiol1.63029023
32MP0001986_abnormal_taste_sensitivity1.60912851
33MP0004381_abnormal_hair_follicle1.60679054
34MP0001968_abnormal_touch/_nociception1.59389920
35MP0002148_abnormal_hypersensitivity_rea1.53140638
36MP0002132_abnormal_respiratory_system1.51778572
37MP0002398_abnormal_bone_marrow1.47619362
38MP0000716_abnormal_immune_system1.46798686
39MP0004742_abnormal_vestibular_system1.44486792
40MP0002452_abnormal_antigen_presenting1.42042919
41MP0002138_abnormal_hepatobiliary_system1.39011799
42MP0005551_abnormal_eye_electrophysiolog1.38024248
43MP0004147_increased_porphyrin_level1.37346480
44MP0002006_tumorigenesis1.34033346
45MP0006072_abnormal_retinal_apoptosis1.32081893
46MP0010155_abnormal_intestine_physiology1.30946137
47MP0004145_abnormal_muscle_electrophysio1.29673634
48MP0001485_abnormal_pinna_reflex1.25612642
49MP0005075_abnormal_melanosome_morpholog1.23606440
50MP0003136_yellow_coat_color1.23260279
51MP0002736_abnormal_nociception_after1.21153139
52MP0000703_abnormal_thymus_morphology1.20219314
53MP0002405_respiratory_system_inflammati1.18291853
54MP0008877_abnormal_DNA_methylation1.17724385
55MP0002653_abnormal_ependyma_morphology1.17402587
56MP0005379_endocrine/exocrine_gland_phen1.16390331
57MP0005389_reproductive_system_phenotype1.15850411
58MP0003195_calcinosis1.12988047
59MP0002429_abnormal_blood_cell1.12412384
60MP0001845_abnormal_inflammatory_respons1.12027950
61MP0001919_abnormal_reproductive_system1.10289950
62MP0002722_abnormal_immune_system1.08084493
63MP0005410_abnormal_fertilization1.07087365
64MP0006276_abnormal_autonomic_nervous1.06571695
65MP0009745_abnormal_behavioral_response1.01684423
66MP0000689_abnormal_spleen_morphology1.01424541
67MP0005360_urolithiasis0.96857029
68MP0001661_extended_life_span0.96829385
69MP0008469_abnormal_protein_level0.96268413
70MP0002160_abnormal_reproductive_system0.95624592
71MP0005646_abnormal_pituitary_gland0.95018183
72MP0001905_abnormal_dopamine_level0.93032681
73MP0002933_joint_inflammation0.92835392
74MP0006036_abnormal_mitochondrial_physio0.92217687
75MP0000678_abnormal_parathyroid_gland0.89159954
76MP0005253_abnormal_eye_physiology0.88991549
77MP0003878_abnormal_ear_physiology0.87792264
78MP0005377_hearing/vestibular/ear_phenot0.87792264
79MP0001119_abnormal_female_reproductive0.87276034
80MP0002419_abnormal_innate_immunity0.86815005
81MP0002693_abnormal_pancreas_physiology0.83192478
82MP0004142_abnormal_muscle_tone0.82870164
83MP0004947_skin_inflammation0.80800909
84MP0006292_abnormal_olfactory_placode0.79857197
85MP0003936_abnormal_reproductive_system0.72125784
86MP0002733_abnormal_thermal_nociception0.71019381
87MP0005084_abnormal_gallbladder_morpholo0.70369957
88MP0002638_abnormal_pupillary_reflex0.69573030
89MP0003137_abnormal_impulse_conducting0.68738809
90MP0005085_abnormal_gallbladder_physiolo0.67746560
91MP0005636_abnormal_mineral_homeostasis0.66904954
92MP0009379_abnormal_foot_pigmentation0.66418513
93MP0009764_decreased_sensitivity_to0.66412849
94MP0001542_abnormal_bone_strength0.65432871
95MP0001984_abnormal_olfaction0.64192818
96MP0002272_abnormal_nervous_system0.62860707
97MP0001765_abnormal_ion_homeostasis0.61965991
98MP0003806_abnormal_nucleotide_metabolis0.61776115
99MP0003638_abnormal_response/metabolism_0.60384881
100MP0009763_increased_sensitivity_to0.60370362

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.51676980
2Abnormality of the renal collecting system (HP:0004742)5.01673854
3Duplicated collecting system (HP:0000081)4.89872809
4Reticulocytopenia (HP:0001896)4.83846075
5Abnormality of T cell number (HP:0011839)4.52947005
6Increased IgM level (HP:0003496)4.48262321
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47008898
8Abnormality of B cell number (HP:0010975)4.24679877
9Autoimmune hemolytic anemia (HP:0001890)4.20741885
10Congenital stationary night blindness (HP:0007642)4.13568400
11Chromsome breakage (HP:0040012)3.87483680
12Abnormality of DNA repair (HP:0003254)3.86960953
13T lymphocytopenia (HP:0005403)3.85159005
14Increased hepatocellular lipid droplets (HP:0006565)3.71019348
15Eosinophilia (HP:0001880)3.65235134
16Hypoproteinemia (HP:0003075)3.60043744
17Abnormality of eosinophils (HP:0001879)3.56315023
18IgG deficiency (HP:0004315)3.54942044
19Abnormality of pyrimidine metabolism (HP:0004353)3.44232651
20Oral leukoplakia (HP:0002745)3.33719761
21Autoimmune thrombocytopenia (HP:0001973)3.32953831
22Renal Fanconi syndrome (HP:0001994)3.27871653
23Lipid accumulation in hepatocytes (HP:0006561)3.23345885
24Pancytopenia (HP:0001876)3.22454143
25Abnormality of T cells (HP:0002843)3.22212606
26Mitochondrial inheritance (HP:0001427)3.21331022
27Absent thumb (HP:0009777)3.17531568
28Renal cortical cysts (HP:0000803)3.15215337
29Increased intramyocellular lipid droplets (HP:0012240)3.10748063
30Acute necrotizing encephalopathy (HP:0006965)3.10163631
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05368127
32Severe combined immunodeficiency (HP:0004430)3.00756871
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94613819
34Chronic diarrhea (HP:0002028)2.94261628
35Abnormality of the renal cortex (HP:0011035)2.90036313
363-Methylglutaconic aciduria (HP:0003535)2.87121102
37Increased CSF lactate (HP:0002490)2.80256289
38Ureteral duplication (HP:0000073)2.80181946
39Abnormal mitochondria in muscle tissue (HP:0008316)2.75599055
40Granulocytopenia (HP:0001913)2.74515566
41Duplication of thumb phalanx (HP:0009942)2.73343799
42Exertional dyspnea (HP:0002875)2.68170607
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.68122223
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.67902255
45Abnormality of the ileum (HP:0001549)2.65644663
46Thyroiditis (HP:0100646)2.62473892
47Progressive macrocephaly (HP:0004481)2.61187257
48Meckel diverticulum (HP:0002245)2.58977749
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57873128
50Acute encephalopathy (HP:0006846)2.55505993
51Pancreatic cysts (HP:0001737)2.54593142
52Elevated erythrocyte sedimentation rate (HP:0003565)2.52314355
53Increased muscle lipid content (HP:0009058)2.52135207
54Stomach cancer (HP:0012126)2.48288435
55Leukocytosis (HP:0001974)2.44108003
56Ectopic kidney (HP:0000086)2.33079419
57Stomatitis (HP:0010280)2.32045970
58Abnormality of the preputium (HP:0100587)2.31896778
59Abnormal rod and cone electroretinograms (HP:0008323)2.31032163
60Clubbing of toes (HP:0100760)2.29978045
61B lymphocytopenia (HP:0010976)2.25758309
62Combined immunodeficiency (HP:0005387)2.25058217
63Horseshoe kidney (HP:0000085)2.20043160
64Cerebral edema (HP:0002181)2.18988478
65Encephalitis (HP:0002383)2.16615474
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.14214408
67Abnormality of urine glucose concentration (HP:0011016)2.10728023
68Glycosuria (HP:0003076)2.10728023
69Attenuation of retinal blood vessels (HP:0007843)2.09866300
70Respiratory difficulties (HP:0002880)2.07840953
71Optic disc pallor (HP:0000543)2.05986029
72Gastrointestinal infarctions (HP:0005244)1.99316363
73Increased serum lactate (HP:0002151)1.94441757
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94208326
75Polydipsia (HP:0001959)1.93062546
76Abnormal drinking behavior (HP:0030082)1.93062546
77Pancreatic fibrosis (HP:0100732)1.92631408
78Neutropenia (HP:0001875)1.92207785
79Hepatic necrosis (HP:0002605)1.90542084
80Abnormality of renal resorption (HP:0011038)1.90427805
81Generalized aminoaciduria (HP:0002909)1.90392277
82Hepatocellular necrosis (HP:0001404)1.89152420
83Abnormality of T cell physiology (HP:0011840)1.89037439
84Abnormality of the prostate (HP:0008775)1.88627300
85Recurrent bronchitis (HP:0002837)1.86811933
86Lymphopenia (HP:0001888)1.86009665
87Abnormality of chromosome stability (HP:0003220)1.83118897
88Joint swelling (HP:0001386)1.82931815
89Decreased central vision (HP:0007663)1.82231994
90Agammaglobulinemia (HP:0004432)1.81408044
91Hyperphosphaturia (HP:0003109)1.80678648
92Aplasia involving forearm bones (HP:0009822)1.80263686
93Absent forearm bone (HP:0003953)1.80263686
94Abolished electroretinogram (ERG) (HP:0000550)1.79543179
95IgM deficiency (HP:0002850)1.78693901
96Cellular immunodeficiency (HP:0005374)1.77423762
97Absent radius (HP:0003974)1.76226831
98Congenital, generalized hypertrichosis (HP:0004540)1.75534447
99Thyroid-stimulating hormone excess (HP:0002925)1.74494070
100Lactic acidosis (HP:0003128)1.74055401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.07005778
2TXK6.69446962
3MAP4K15.53698109
4KDR4.20465344
5TESK24.11295604
6BCKDK3.79057120
7ADRBK22.12183494
8LIMK12.01857764
9GRK11.99277541
10ZAK1.75277812
11ITK1.75174558
12FRK1.68347090
13TLK11.62506873
14ZAP701.60676052
15STK161.45609604
16TIE11.40574121
17SYK1.23935794
18VRK21.22551808
19CAMKK21.15125295
20TESK11.14478615
21MAP3K111.12450330
22MAP3K121.09412789
23TEC1.09071429
24BUB11.04520178
25MUSK1.04375136
26VRK11.04084106
27LCK0.99312458
28WNK40.97394714
29NUAK10.96667568
30PASK0.94699040
31FES0.93888676
32PINK10.93766683
33BTK0.88927795
34PRKCQ0.88335796
35GRK70.87534989
36MAP4K20.82957633
37CAMKK10.82087935
38PIK3CA0.81695718
39CSK0.78592293
40IKBKB0.78339340
41INSRR0.76207095
42LYN0.73943892
43MAPK130.71596110
44IKBKE0.69588675
45SRPK10.67498587
46MAPKAPK30.64291627
47ADRBK10.63678341
48GRK60.63032750
49MYLK0.61842002
50OBSCN0.57035357
51IGF1R0.56102690
52MAP2K60.54110115
53HCK0.50780950
54WNK30.49266407
55EIF2AK10.48349882
56EIF2AK30.47935644
57TNK20.46730464
58CDK80.45402345
59BMPR1B0.45342199
60TYRO30.45322696
61JAK30.44200003
62CSNK1G10.43072737
63FYN0.40197702
64RPS6KA50.40085109
65DAPK10.39009352
66TRPM70.37059387
67PRKCA0.35118141
68CSNK1G30.34454729
69NLK0.34355063
70PIM10.33824961
71KIT0.33572153
72NME10.32434414
73TAOK20.31497926
74PRKACA0.29652277
75SGK10.27891755
76MAPK150.27244899
77INSR0.25260861
78MAP3K50.25220518
79ATR0.24600057
80CAMK2A0.24557874
81OXSR10.24437159
82PRKCE0.22866039
83DYRK20.22757155
84PHKG20.22510801
85PHKG10.22510801
86ROCK10.22485435
87CSNK1A10.22477239
88CSNK1A1L0.22437076
89PIK3CG0.22333669
90TBK10.22170252
91MAPK110.21722368
92MAPKAPK20.21637662
93CSNK2A10.21450751
94PRKAA20.21419642
95ERBB20.20443116
96SCYL20.19820045
97CSNK2A20.17444458
98PRKCH0.16766738
99AURKA0.16725641
100CAMK10.16720679

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.81349988
2Oxidative phosphorylation_Homo sapiens_hsa001903.55747746
3Proteasome_Homo sapiens_hsa030503.26337484
4Graft-versus-host disease_Homo sapiens_hsa053323.05309788
5Autoimmune thyroid disease_Homo sapiens_hsa053202.95688831
6Allograft rejection_Homo sapiens_hsa053302.89855937
7Parkinsons disease_Homo sapiens_hsa050122.87174681
8Ribosome_Homo sapiens_hsa030102.80245650
9Antigen processing and presentation_Homo sapiens_hsa046122.53854740
10Type I diabetes mellitus_Homo sapiens_hsa049402.34602181
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25438207
12Hematopoietic cell lineage_Homo sapiens_hsa046402.22571758
13T cell receptor signaling pathway_Homo sapiens_hsa046602.12959811
14Phototransduction_Homo sapiens_hsa047442.00581184
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96021218
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.85349059
17Alzheimers disease_Homo sapiens_hsa050101.78796208
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70816481
19Cardiac muscle contraction_Homo sapiens_hsa042601.69121586
20Protein export_Homo sapiens_hsa030601.66387952
21Huntingtons disease_Homo sapiens_hsa050161.62160094
22RNA polymerase_Homo sapiens_hsa030201.57119246
23Linoleic acid metabolism_Homo sapiens_hsa005911.52904757
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50644930
25Nitrogen metabolism_Homo sapiens_hsa009101.47800774
26Asthma_Homo sapiens_hsa053101.47525057
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45815120
28Caffeine metabolism_Homo sapiens_hsa002321.37762906
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32913928
30Rheumatoid arthritis_Homo sapiens_hsa053231.32451487
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27408751
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25088121
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17773422
34Viral myocarditis_Homo sapiens_hsa054161.17429491
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10156882
36Malaria_Homo sapiens_hsa051441.04909878
37Fanconi anemia pathway_Homo sapiens_hsa034601.03389738
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94858067
39Measles_Homo sapiens_hsa051620.94017036
40RNA degradation_Homo sapiens_hsa030180.89662121
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.85803672
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.84619339
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.83148817
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82945246
45Basal transcription factors_Homo sapiens_hsa030220.81953519
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80363643
47Propanoate metabolism_Homo sapiens_hsa006400.80175297
48Nicotine addiction_Homo sapiens_hsa050330.79639174
49Ether lipid metabolism_Homo sapiens_hsa005650.77518087
50Olfactory transduction_Homo sapiens_hsa047400.74008436
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71276375
52Chemical carcinogenesis_Homo sapiens_hsa052040.69962969
53Systemic lupus erythematosus_Homo sapiens_hsa053220.69174687
54Pyrimidine metabolism_Homo sapiens_hsa002400.67769937
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67319521
56Purine metabolism_Homo sapiens_hsa002300.66685411
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66532141
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64219220
59Butanoate metabolism_Homo sapiens_hsa006500.64149303
60Taste transduction_Homo sapiens_hsa047420.63510900
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62865661
62Homologous recombination_Homo sapiens_hsa034400.62854495
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62692077
64Arachidonic acid metabolism_Homo sapiens_hsa005900.62011271
65Mineral absorption_Homo sapiens_hsa049780.59332824
66Vitamin B6 metabolism_Homo sapiens_hsa007500.56449908
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.56080000
68Retinol metabolism_Homo sapiens_hsa008300.53865953
69Staphylococcus aureus infection_Homo sapiens_hsa051500.52409758
70One carbon pool by folate_Homo sapiens_hsa006700.51104081
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49880201
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49152738
73Morphine addiction_Homo sapiens_hsa050320.47692255
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47073868
75Collecting duct acid secretion_Homo sapiens_hsa049660.46538586
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44944467
77Sulfur relay system_Homo sapiens_hsa041220.43957509
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43204402
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.42942011
80Ovarian steroidogenesis_Homo sapiens_hsa049130.41360290
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.40445004
82Peroxisome_Homo sapiens_hsa041460.39388769
83Mismatch repair_Homo sapiens_hsa034300.37763465
84Nucleotide excision repair_Homo sapiens_hsa034200.36947528
85Metabolic pathways_Homo sapiens_hsa011000.34238613
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34209200
87Salivary secretion_Homo sapiens_hsa049700.33996108
88Pyruvate metabolism_Homo sapiens_hsa006200.31169827
89Sulfur metabolism_Homo sapiens_hsa009200.30551561
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30223375
91Fat digestion and absorption_Homo sapiens_hsa049750.29458838
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28423968
93Spliceosome_Homo sapiens_hsa030400.27904422
94Herpes simplex infection_Homo sapiens_hsa051680.27044669
95Shigellosis_Homo sapiens_hsa051310.23317012
96Salmonella infection_Homo sapiens_hsa051320.22409882
97DNA replication_Homo sapiens_hsa030300.21675426
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19631862
99Chemokine signaling pathway_Homo sapiens_hsa040620.19100778
100Tryptophan metabolism_Homo sapiens_hsa003800.17661894

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