RPL23AP30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.28462672
2DNA deamination (GO:0045006)5.59481871
3regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.95557017
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.51389698
5regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.51389698
6regulation of response to tumor cell (GO:0002834)4.22836551
7positive regulation of response to tumor cell (GO:0002836)4.22836551
8positive regulation of immune response to tumor cell (GO:0002839)4.22836551
9regulation of immune response to tumor cell (GO:0002837)4.22836551
10axoneme assembly (GO:0035082)4.11066395
11regulation of interleukin-12 biosynthetic process (GO:0045075)4.07976194
12rRNA modification (GO:0000154)3.92748515
13regulation of isotype switching to IgG isotypes (GO:0048302)3.91500088
14forebrain morphogenesis (GO:0048853)3.90261100
15male meiosis I (GO:0007141)3.71550690
16cytidine metabolic process (GO:0046087)3.65871342
17cytidine catabolic process (GO:0006216)3.65871342
18cytidine deamination (GO:0009972)3.65871342
19rRNA methylation (GO:0031167)3.63527872
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61718877
21transcription from mitochondrial promoter (GO:0006390)3.61708161
22pseudouridine synthesis (GO:0001522)3.60135791
23histone mRNA metabolic process (GO:0008334)3.55788318
24proteasome assembly (GO:0043248)3.54010895
25regulation of podosome assembly (GO:0071801)3.48048414
26male meiosis (GO:0007140)3.44194049
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.43582886
28NADH dehydrogenase complex assembly (GO:0010257)3.43582886
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43582886
30mitochondrial respiratory chain complex assembly (GO:0033108)3.37164310
31olfactory bulb development (GO:0021772)3.35058382
32rRNA processing (GO:0006364)3.30885870
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.27074938
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26607699
35rRNA metabolic process (GO:0016072)3.26105638
36reciprocal DNA recombination (GO:0035825)3.25296333
37reciprocal meiotic recombination (GO:0007131)3.25296333
38histone mRNA catabolic process (GO:0071044)3.23909270
39meiotic chromosome segregation (GO:0045132)3.23658800
40alpha-beta T cell differentiation involved in immune response (GO:0002293)3.21529883
41alpha-beta T cell activation involved in immune response (GO:0002287)3.21529883
42T cell differentiation involved in immune response (GO:0002292)3.21529883
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.17552400
44regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.15415698
45GTP biosynthetic process (GO:0006183)3.13948754
46synapsis (GO:0007129)3.11385932
47ribosomal small subunit assembly (GO:0000028)3.07384045
48meiosis I (GO:0007127)3.07026967
49protein complex biogenesis (GO:0070271)3.06967341
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.03299278
51nucleobase biosynthetic process (GO:0046112)3.02028909
52regulation of vitamin D biosynthetic process (GO:0060556)2.98624518
53negative regulation of interleukin-17 production (GO:0032700)2.98507104
54UTP biosynthetic process (GO:0006228)2.97452243
55replicative senescence (GO:0090399)2.93160886
56regulation of interleukin-6 biosynthetic process (GO:0045408)2.92575362
57maturation of 5.8S rRNA (GO:0000460)2.91593536
58negative regulation of metanephros development (GO:0072217)2.91503877
59regulation of MHC class II biosynthetic process (GO:0045346)2.91342799
60positive regulation of muscle cell apoptotic process (GO:0010661)2.91212303
61regulation of DNA endoreduplication (GO:0032875)2.91049907
62meiotic nuclear division (GO:0007126)2.90387937
63protein-cofactor linkage (GO:0018065)2.88941313
64positive regulation of osteoclast differentiation (GO:0045672)2.88159680
65mitochondrial RNA metabolic process (GO:0000959)2.85636875
66DNA-dependent DNA replication (GO:0006261)2.85139476
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85060007
68piRNA metabolic process (GO:0034587)2.83128916
69respiratory chain complex IV assembly (GO:0008535)2.82648955
70purine nucleotide salvage (GO:0032261)2.77840579
71activated T cell proliferation (GO:0050798)2.77755959
72positive regulation of DNA recombination (GO:0045911)2.75060582
73purine nucleobase biosynthetic process (GO:0009113)2.73497699
74protein K6-linked ubiquitination (GO:0085020)2.71623214
75positive regulation of interleukin-1 beta secretion (GO:0050718)2.71238395
76guanosine-containing compound biosynthetic process (GO:1901070)2.70267527
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69920554
78cytokinetic process (GO:0032506)2.69908870
79UTP metabolic process (GO:0046051)2.68225392
80positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.66400894
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64840035
82maturation of SSU-rRNA (GO:0030490)2.63290282
83negative regulation of B cell proliferation (GO:0030889)2.61263374
84T cell migration (GO:0072678)2.60730416
85regulation of meiosis I (GO:0060631)2.59732456
86negative regulation of neurological system process (GO:0031645)2.59286368
87replication fork processing (GO:0031297)2.56838364
88negative regulation of kidney development (GO:0090185)2.56434328
89spindle assembly involved in mitosis (GO:0090307)2.56174748
90regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.55396121
91negative regulation of B cell activation (GO:0050869)2.55168903
92regulation of centriole replication (GO:0046599)2.54623497
93mitotic sister chromatid cohesion (GO:0007064)2.54400009
94defense response to protozoan (GO:0042832)2.52526523
95ATP synthesis coupled proton transport (GO:0015986)2.51217549
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.51217549
97positive regulation of interleukin-1 secretion (GO:0050716)2.51160726
98pyrimidine ribonucleoside metabolic process (GO:0046131)2.50657138
99resolution of meiotic recombination intermediates (GO:0000712)2.50491101
100DNA methylation involved in gamete generation (GO:0043046)2.49083583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.95973392
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65986121
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45704058
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.06477293
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90708191
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88780207
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.88598650
8VDR_23849224_ChIP-Seq_CD4+_Human2.87343345
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81492339
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77584998
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73781202
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.71347829
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.59993249
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.56041210
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53985942
16ZNF274_21170338_ChIP-Seq_K562_Hela2.51914616
17E2F7_22180533_ChIP-Seq_HELA_Human2.49676304
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32552555
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31999990
20EWS_26573619_Chip-Seq_HEK293_Human2.23043328
21ELK1_19687146_ChIP-ChIP_HELA_Human2.14233951
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14113667
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03815055
24FOXP3_21729870_ChIP-Seq_TREG_Human1.84941308
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78664988
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.68677311
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67328059
28GABP_19822575_ChIP-Seq_HepG2_Human1.66033641
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64925648
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63159329
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.56935015
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55274797
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54661933
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53109877
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51276292
36IRF1_19129219_ChIP-ChIP_H3396_Human1.51225760
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47961241
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46983361
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.43548900
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.42277795
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41891302
42DCP1A_22483619_ChIP-Seq_HELA_Human1.40890745
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38768759
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38394679
45TTF2_22483619_ChIP-Seq_HELA_Human1.36577884
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32791122
47TP53_22573176_ChIP-Seq_HFKS_Human1.31586192
48VDR_22108803_ChIP-Seq_LS180_Human1.30889897
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30495848
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30183208
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.29090938
52FUS_26573619_Chip-Seq_HEK293_Human1.28395079
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28141379
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25733910
55KDM5A_27292631_Chip-Seq_BREAST_Human1.25458883
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24471200
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19808003
58MYC_18940864_ChIP-ChIP_HL60_Human1.19591105
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16754391
60GATA3_26560356_Chip-Seq_TH2_Human1.16047714
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15864795
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15849796
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15389643
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15387609
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15256379
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.12085352
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11384673
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.10372919
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08267757
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.07102354
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07009802
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.07009802
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06975727
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06931821
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05427571
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.04187582
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03932650
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02014020
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01249137
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01053681
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00698483
82HTT_18923047_ChIP-ChIP_STHdh_Human0.97938888
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97494811
84CDX2_22108803_ChIP-Seq_LS180_Human0.96232473
85GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.95950467
86ER_23166858_ChIP-Seq_MCF-7_Human0.95372900
87STAT3_18555785_Chip-Seq_ESCs_Mouse0.95363723
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.94775104
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92591490
90NANOG_19829295_ChIP-Seq_ESCs_Human0.92395570
91SOX2_19829295_ChIP-Seq_ESCs_Human0.92395570
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92246870
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91675275
94THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91005045
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90925715
96MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90884333
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90621934
98HOXB7_26014856_ChIP-Seq_BT474_Human0.89864620
99NCOR_22424771_ChIP-Seq_293T_Human0.89507757
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89301405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.11790506
2MP0003183_abnormal_peptide_metabolism3.66683984
3MP0000569_abnormal_digit_pigmentation3.63401398
4MP0008057_abnormal_DNA_replication3.10507497
5MP0005671_abnormal_response_to2.96240288
6MP0001835_abnormal_antigen_presentation2.84524685
7MP0010094_abnormal_chromosome_stability2.67894038
8MP0001873_stomach_inflammation2.66388535
9MP0003693_abnormal_embryo_hatching2.56008512
10MP0005670_abnormal_white_adipose2.48099325
11MP0000427_abnormal_hair_cycle2.43719730
12MP0000383_abnormal_hair_follicle2.36663132
13MP0002163_abnormal_gland_morphology2.28872885
14MP0002102_abnormal_ear_morphology2.16221109
15MP0004381_abnormal_hair_follicle2.10126257
16MP0010307_abnormal_tumor_latency2.08642538
17MP0003646_muscle_fatigue2.03615674
18MP0000015_abnormal_ear_pigmentation2.03367077
19MP0000685_abnormal_immune_system1.96144779
20MP0008058_abnormal_DNA_repair1.95524042
21MP0001188_hyperpigmentation1.92403983
22MP0010678_abnormal_skin_adnexa1.88423142
23MP0002166_altered_tumor_susceptibility1.87622865
24MP0003077_abnormal_cell_cycle1.80323307
25MP0001984_abnormal_olfaction1.75138193
26MP0003787_abnormal_imprinting1.73847378
27MP0008007_abnormal_cellular_replicative1.72637999
28MP0002006_tumorigenesis1.71018456
29MP0008875_abnormal_xenobiotic_pharmacok1.68196073
30MP0006292_abnormal_olfactory_placode1.65987421
31MP0005389_reproductive_system_phenotype1.62787777
32MP0005387_immune_system_phenotype1.62242215
33MP0001790_abnormal_immune_system1.62242215
34MP0002160_abnormal_reproductive_system1.57863966
35MP0001800_abnormal_humoral_immune1.57834432
36MP0005174_abnormal_tail_pigmentation1.56203034
37MP0008872_abnormal_physiological_respon1.51255535
38MP0003186_abnormal_redox_activity1.47101648
39MP0006035_abnormal_mitochondrial_morpho1.45934194
40MP0002638_abnormal_pupillary_reflex1.45670675
41MP0002095_abnormal_skin_pigmentation1.44340200
42MP0003763_abnormal_thymus_physiology1.41141111
43MP0009333_abnormal_splenocyte_physiolog1.34331852
44MP0003195_calcinosis1.34323572
45MP0003786_premature_aging1.33870690
46MP0003567_abnormal_fetal_cardiomyocyte1.32360042
47MP0006036_abnormal_mitochondrial_physio1.31883786
48MP0004142_abnormal_muscle_tone1.29528940
49MP0002405_respiratory_system_inflammati1.28384620
50MP0003806_abnormal_nucleotide_metabolis1.27997448
51MP0002148_abnormal_hypersensitivity_rea1.25737102
52MP0009379_abnormal_foot_pigmentation1.21156072
53MP0003111_abnormal_nucleus_morphology1.20735201
54MP0000647_abnormal_sebaceous_gland1.20521546
55MP0004957_abnormal_blastocyst_morpholog1.18561734
56MP0005075_abnormal_melanosome_morpholog1.17880452
57MP0004782_abnormal_surfactant_physiolog1.17805286
58MP0009785_altered_susceptibility_to1.14636972
59MP0002420_abnormal_adaptive_immunity1.11731566
60MP0001819_abnormal_immune_cell1.10992958
61MP0001958_emphysema1.10875465
62MP0005076_abnormal_cell_differentiation1.10569655
63MP0000703_abnormal_thymus_morphology1.06605752
64MP0002722_abnormal_immune_system1.04551201
65MP0001919_abnormal_reproductive_system1.04016587
66MP0001929_abnormal_gametogenesis1.02063054
67MP0002009_preneoplasia1.02036901
68MP0000689_abnormal_spleen_morphology1.01800611
69MP0004885_abnormal_endolymph0.98964601
70MP0002452_abnormal_antigen_presenting0.98261757
71MP0002210_abnormal_sex_determination0.97558921
72MP0001145_abnormal_male_reproductive0.95926132
73MP0005379_endocrine/exocrine_gland_phen0.94835352
74MP0002723_abnormal_immune_serum0.94469439
75MP0005551_abnormal_eye_electrophysiolog0.93220244
76MP0000653_abnormal_sex_gland0.92005586
77MP0003936_abnormal_reproductive_system0.91740075
78MP0002090_abnormal_vision0.88836178
79MP0003436_decreased_susceptibility_to0.88037532
80MP0005000_abnormal_immune_tolerance0.86933983
81MP0001119_abnormal_female_reproductive0.86875512
82MP0002928_abnormal_bile_duct0.86608622
83MP0002398_abnormal_bone_marrow0.86493807
84MP0005084_abnormal_gallbladder_morpholo0.85031807
85MP0000716_abnormal_immune_system0.83013623
86MP0002693_abnormal_pancreas_physiology0.82284726
87MP0005319_abnormal_enzyme/_coenzyme0.82258043
88MP0004145_abnormal_muscle_electrophysio0.79098774
89MP0008873_increased_physiological_sensi0.78736705
90MP0002019_abnormal_tumor_incidence0.77791126
91MP0003698_abnormal_male_reproductive0.76896278
92MP0002876_abnormal_thyroid_physiology0.71263853
93MP0002429_abnormal_blood_cell0.70400315
94MP0000678_abnormal_parathyroid_gland0.68786885
95MP0008932_abnormal_embryonic_tissue0.68394130
96MP0003121_genomic_imprinting0.67163704
97MP0002132_abnormal_respiratory_system0.66593225
98MP0002138_abnormal_hepatobiliary_system0.66429916
99MP0001293_anophthalmia0.64514340
100MP0008770_decreased_survivor_rate0.63056034

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)4.79104735
2Constricted visual fields (HP:0001133)3.68276963
3Stomatitis (HP:0010280)3.42651787
4Acute necrotizing encephalopathy (HP:0006965)3.30900192
5Abnormality of alanine metabolism (HP:0010916)3.29227252
6Hyperalaninemia (HP:0003348)3.29227252
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.29227252
8Oligodactyly (HP:0012165)3.23092361
9Progressive macrocephaly (HP:0004481)3.20514008
10Pancreatic cysts (HP:0001737)3.19630724
11Ectopic kidney (HP:0000086)3.13349863
12Papilledema (HP:0001085)2.92903712
13Meckel diverticulum (HP:0002245)2.87270971
14Abnormality of the ileum (HP:0001549)2.81958265
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80532841
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.75789712
17Hypomagnesemia (HP:0002917)2.74349145
18Abnormality of the renal cortex (HP:0011035)2.72344995
19Abnormality of chromosome stability (HP:0003220)2.71995073
20Cutaneous melanoma (HP:0012056)2.71893277
21Volvulus (HP:0002580)2.68256104
22Pancreatic fibrosis (HP:0100732)2.67694293
23Increased CSF lactate (HP:0002490)2.67296729
24Abnormal mitochondria in muscle tissue (HP:0008316)2.65790330
25Stenosis of the external auditory canal (HP:0000402)2.64006556
26Reticulocytopenia (HP:0001896)2.60808333
27Birth length less than 3rd percentile (HP:0003561)2.60576407
28T lymphocytopenia (HP:0005403)2.57946813
29Chromsome breakage (HP:0040012)2.52357604
30Congenital stationary night blindness (HP:0007642)2.49305881
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47487567
32Mitochondrial inheritance (HP:0001427)2.46683951
33Metaphyseal dysplasia (HP:0100255)2.43214014
34Hypoproteinemia (HP:0003075)2.42896023
35Acute encephalopathy (HP:0006846)2.42041287
36Hypoplasia of the radius (HP:0002984)2.32381623
37Abnormality of T cell number (HP:0011839)2.30743694
38Abnormality of the labia minora (HP:0012880)2.25898771
39True hermaphroditism (HP:0010459)2.24462917
40Molar tooth sign on MRI (HP:0002419)2.24172055
41Abnormality of midbrain morphology (HP:0002418)2.24172055
42Abnormality of the preputium (HP:0100587)2.23249356
43Absent thumb (HP:0009777)2.21309435
44Occipital encephalocele (HP:0002085)2.19277321
45Optic nerve coloboma (HP:0000588)2.17001914
46Labial hypoplasia (HP:0000066)2.16604967
47Duodenal stenosis (HP:0100867)2.14313986
48Small intestinal stenosis (HP:0012848)2.14313986
49IgG deficiency (HP:0004315)2.11003114
50Clubbing of toes (HP:0100760)2.10318381
51Abnormality of magnesium homeostasis (HP:0004921)2.09549575
52Hypoplastic female external genitalia (HP:0012815)2.08597151
53Optic disc pallor (HP:0000543)2.07515614
54Abnormal rod and cone electroretinograms (HP:0008323)2.04947264
55Increased serum pyruvate (HP:0003542)2.03705585
56Asplenia (HP:0001746)2.02396551
57Duplicated collecting system (HP:0000081)1.99737078
58Hypoplastic nipples (HP:0002557)1.98852549
59IgA deficiency (HP:0002720)1.98040506
60Fair hair (HP:0002286)1.97361534
61Abnormality of the renal medulla (HP:0100957)1.96210883
62Sclerocornea (HP:0000647)1.96163092
63Increased serum lactate (HP:0002151)1.95087706
64Aplasia/Hypoplasia of the macula (HP:0008059)1.94386424
65Triphalangeal thumb (HP:0001199)1.94077050
66Abnormality of T cells (HP:0002843)1.94073237
67Aplasia/Hypoplasia of the spleen (HP:0010451)1.93205759
68Cerebral edema (HP:0002181)1.93190744
69Horizontal nystagmus (HP:0000666)1.92956162
70Absent radius (HP:0003974)1.92338528
71Tubular atrophy (HP:0000092)1.90039648
72Hypoplastic labia majora (HP:0000059)1.89370290
73Breast hypoplasia (HP:0003187)1.89251958
74Lipid accumulation in hepatocytes (HP:0006561)1.87733557
75Testicular atrophy (HP:0000029)1.87205964
76Blepharitis (HP:0000498)1.86435122
77Flat capital femoral epiphysis (HP:0003370)1.85889848
78Abnormality of the prostate (HP:0008775)1.85872453
79Abnormality of DNA repair (HP:0003254)1.84673064
80Respiratory failure (HP:0002878)1.84587607
81Bile duct proliferation (HP:0001408)1.83993835
82Abnormal biliary tract physiology (HP:0012439)1.83993835
83Abnormality of the renal collecting system (HP:0004742)1.83574751
84Short middle phalanx of the 5th finger (HP:0004220)1.83166576
85Leukodystrophy (HP:0002415)1.83119368
86Aplasia/hypoplasia of the uterus (HP:0008684)1.81628466
87Absent forearm bone (HP:0003953)1.80780093
88Aplasia involving forearm bones (HP:0009822)1.80780093
89Mediastinal lymphadenopathy (HP:0100721)1.78506834
90Abnormality of the duodenum (HP:0002246)1.78483057
91Horseshoe kidney (HP:0000085)1.77980459
92Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77963127
93Neoplasm of the adrenal cortex (HP:0100641)1.74334060
94Abnormality of the labia majora (HP:0012881)1.74003033
95Autoimmune hemolytic anemia (HP:0001890)1.72802385
96Attenuation of retinal blood vessels (HP:0007843)1.72605653
97Forearm undergrowth (HP:0009821)1.69798719
98Hypoplasia of the uterus (HP:0000013)1.68362819
99Sloping forehead (HP:0000340)1.66958056
100Nephronophthisis (HP:0000090)1.66650479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.68454956
2FRK3.62749594
3NUAK13.13814890
4TXK2.87957652
5ZAK2.82941514
6MAP3K122.54277221
7TRIM282.36131881
8EIF2AK12.30358356
9NEK12.06470472
10MAP2K61.90543009
11SRPK11.86358127
12OXSR11.86223903
13TSSK61.82421765
14WNK41.82387490
15BMPR1B1.78793882
16EIF2AK31.76261580
17PIK3CG1.73832397
18PDK21.69657852
19STK391.68340322
20MAP3K111.65958987
21VRK21.61899892
22TEC1.59920441
23PLK31.58328658
24TAF11.47856043
25PNCK1.47656835
26MKNK21.40232555
27BMPR21.33779789
28GRK11.28988201
29CSF1R1.28769499
30GRK71.28726345
31NME21.24350679
32PBK1.23705662
33IKBKB1.21545021
34TLK11.21135263
35MAP4K21.18032384
36EIF2AK21.16591351
37NME11.11558055
38FGFR21.10289402
39PHKG11.07079997
40PHKG21.07079997
41TAOK31.06956106
42NLK1.04956473
43MKNK11.04270974
44DYRK21.02196439
45STK41.01205416
46PLK21.00979194
47FGR0.96588704
48PLK10.96450947
49PTK2B0.95831919
50ATR0.93169217
51PASK0.91411724
52MAP4K10.90778873
53ITK0.87583162
54LRRK20.84573757
55VRK10.84217467
56CHEK20.82152953
57CCNB10.80472227
58MAP3K50.79592782
59PIK3CA0.78400405
60IRAK10.77623079
61TGFBR10.75692850
62CAMK1G0.74437343
63AKT30.72798283
64TIE10.69446953
65ADRBK20.65052886
66BUB10.64191171
67BRSK20.62908484
68AURKB0.61195489
69ADRBK10.60019239
70PLK40.59655130
71MELK0.58050641
72MAP2K30.56825696
73JAK30.55064441
74WNK10.55006470
75RPS6KB10.54860547
76PIM10.54294597
77ATM0.53871784
78STK100.51224733
79PRKCG0.50896185
80GRK50.50477619
81PRKCI0.49695848
82TTK0.48622231
83FGFR30.48251426
84BTK0.45268746
85CAMKK20.44875647
86IGF1R0.41433910
87BCKDK0.37492298
88ACVR1B0.36778371
89WEE10.35841095
90CHEK10.35765969
91CDC70.34997403
92STK160.32241208
93BRSK10.31251342
94LCK0.30957922
95NEK20.29344412
96CSNK1A1L0.28304487
97PRKCQ0.28298976
98DAPK10.27463458
99STK110.26575176
100KIT0.26188998

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.76553095
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42670854
3Ribosome_Homo sapiens_hsa030103.30649360
4Fanconi anemia pathway_Homo sapiens_hsa034603.23562098
5Homologous recombination_Homo sapiens_hsa034402.77578596
6Oxidative phosphorylation_Homo sapiens_hsa001902.72526331
7Parkinsons disease_Homo sapiens_hsa050122.56615841
8DNA replication_Homo sapiens_hsa030302.35615901
9RNA degradation_Homo sapiens_hsa030182.27293581
10Basal transcription factors_Homo sapiens_hsa030222.25889521
11Mismatch repair_Homo sapiens_hsa034302.24214557
12RNA polymerase_Homo sapiens_hsa030202.19753160
13Graft-versus-host disease_Homo sapiens_hsa053322.14650077
14Huntingtons disease_Homo sapiens_hsa050162.00526099
15One carbon pool by folate_Homo sapiens_hsa006701.98383575
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80310904
17Spliceosome_Homo sapiens_hsa030401.78807852
18Regulation of autophagy_Homo sapiens_hsa041401.77258742
19Primary immunodeficiency_Homo sapiens_hsa053401.73834949
20RNA transport_Homo sapiens_hsa030131.73530614
21Nucleotide excision repair_Homo sapiens_hsa034201.66143102
22Antigen processing and presentation_Homo sapiens_hsa046121.65755319
23Alzheimers disease_Homo sapiens_hsa050101.63606064
24T cell receptor signaling pathway_Homo sapiens_hsa046601.61759864
25Nitrogen metabolism_Homo sapiens_hsa009101.57014725
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53748863
27Linoleic acid metabolism_Homo sapiens_hsa005911.53622020
28Pyrimidine metabolism_Homo sapiens_hsa002401.53621606
29Protein export_Homo sapiens_hsa030601.47462856
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38829706
31African trypanosomiasis_Homo sapiens_hsa051431.36840492
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36247541
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31199065
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28961341
35Non-homologous end-joining_Homo sapiens_hsa034501.28381740
36Base excision repair_Homo sapiens_hsa034101.27333922
37Allograft rejection_Homo sapiens_hsa053301.20856392
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13464362
39Ether lipid metabolism_Homo sapiens_hsa005651.13093546
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.06959367
41Purine metabolism_Homo sapiens_hsa002301.02939009
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00511789
43Hematopoietic cell lineage_Homo sapiens_hsa046400.93940749
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91350783
45Propanoate metabolism_Homo sapiens_hsa006400.89961908
46p53 signaling pathway_Homo sapiens_hsa041150.89782889
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.87685004
48Cell cycle_Homo sapiens_hsa041100.87093509
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85340799
50Phototransduction_Homo sapiens_hsa047440.85096106
51Type I diabetes mellitus_Homo sapiens_hsa049400.79438818
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74134821
53Folate biosynthesis_Homo sapiens_hsa007900.73314956
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72267717
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70187212
56Selenocompound metabolism_Homo sapiens_hsa004500.69301626
57Pyruvate metabolism_Homo sapiens_hsa006200.65235144
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65169203
59Steroid biosynthesis_Homo sapiens_hsa001000.61344630
60Tryptophan metabolism_Homo sapiens_hsa003800.59996647
61Cardiac muscle contraction_Homo sapiens_hsa042600.58530807
62Fatty acid elongation_Homo sapiens_hsa000620.56897788
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53598846
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51570220
65Malaria_Homo sapiens_hsa051440.50282034
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50174362
67Measles_Homo sapiens_hsa051620.50166532
68Systemic lupus erythematosus_Homo sapiens_hsa053220.49432729
69Metabolic pathways_Homo sapiens_hsa011000.48390448
70Fatty acid biosynthesis_Homo sapiens_hsa000610.46893741
71Butanoate metabolism_Homo sapiens_hsa006500.46505512
72Epstein-Barr virus infection_Homo sapiens_hsa051690.45057857
73TNF signaling pathway_Homo sapiens_hsa046680.44703830
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44533067
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44248624
76Autoimmune thyroid disease_Homo sapiens_hsa053200.41432035
77Lysine degradation_Homo sapiens_hsa003100.40845770
78Peroxisome_Homo sapiens_hsa041460.39356054
79Fatty acid metabolism_Homo sapiens_hsa012120.37479687
80N-Glycan biosynthesis_Homo sapiens_hsa005100.36863448
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.34747653
82Arachidonic acid metabolism_Homo sapiens_hsa005900.34691348
83mRNA surveillance pathway_Homo sapiens_hsa030150.34535126
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33906921
85Legionellosis_Homo sapiens_hsa051340.33170352
86Rheumatoid arthritis_Homo sapiens_hsa053230.33125682
87Caffeine metabolism_Homo sapiens_hsa002320.33118121
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31368705
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30868215
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.30120552
91Fatty acid degradation_Homo sapiens_hsa000710.29925152
92Leishmaniasis_Homo sapiens_hsa051400.29609952
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28590843
94Chemical carcinogenesis_Homo sapiens_hsa052040.28424801
95Ovarian steroidogenesis_Homo sapiens_hsa049130.28297144
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26574651
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.26308719
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.25966512
99TGF-beta signaling pathway_Homo sapiens_hsa043500.25252877
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24920799

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