ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.23984801
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.91440156
3	regulation of regulatory T cell differentiation (GO:0045589)	4.98758476
4	negative regulation of B cell apoptotic process (GO:0002903)	4.91021787
5	proteasome assembly (GO:0043248)	4.79850297
6	rRNA modification (GO:0000154)	4.79339107
7	regulation of immunoglobulin secretion (GO:0051023)	4.77518433
8	regulation of isotype switching to IgG isotypes (GO:0048302)	4.73086264
9	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	4.72525090
10	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	4.72525090
11	isotype switching (GO:0045190)	4.72525090
12	rRNA methylation (GO:0031167)	4.59001132
13	tolerance induction (GO:0002507)	4.53301172
14	positive regulation of interleukin-17 production (GO:0032740)	4.37980650
15	regulation of B cell apoptotic process (GO:0002902)	4.18313322
16	signal peptide processing (GO:0006465)	4.05122128
17	DNA deamination (GO:0045006)	4.00300016
18	positive regulation of isotype switching (GO:0045830)	4.00047183
19	behavioral response to nicotine (GO:0035095)	3.98688565
20	positive regulation of DNA recombination (GO:0045911)	3.98508992
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.73733011
22	positive regulation of defense response to virus by host (GO:0002230)	3.72178119
23	positive regulation of T cell migration (GO:2000406)	3.58174242
24	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.46684821
25	piRNA metabolic process (GO:0034587)	3.42980477
26	interferon-gamma production (GO:0032609)	3.42559723
27	L-methionine biosynthetic process (GO:0071265)	3.41826407
28	amino acid salvage (GO:0043102)	3.41826407
29	L-methionine salvage (GO:0071267)	3.41826407
30	ribosomal large subunit biogenesis (GO:0042273)	3.40214044
31	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.36554437
32	positive regulation of activated T cell proliferation (GO:0042104)	3.35102922
33	somatic diversification of immunoglobulins (GO:0016445)	3.32455311
34	cellular response to exogenous dsRNA (GO:0071360)	3.22113292
35	regulation of germinal center formation (GO:0002634)	3.17281114
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.15351186
37	positive regulation of prostaglandin secretion (GO:0032308)	3.14960114
38	protein-cofactor linkage (GO:0018065)	3.12934784
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.12023496
40	ATP synthesis coupled proton transport (GO:0015986)	3.12023496
41	regulation of mitochondrial translation (GO:0070129)	3.11484443
42	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.09452344
43	regulation of mitotic spindle checkpoint (GO:1903504)	3.09452344
44	regulation of T cell receptor signaling pathway (GO:0050856)	3.09190660
45	cytochrome complex assembly (GO:0017004)	3.05867052
46	cellular response to ATP (GO:0071318)	3.00223734
47	regulation of T cell migration (GO:2000404)	2.97550110
48	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.93726172
49	respiratory chain complex IV assembly (GO:0008535)	2.90236736
50	B cell activation involved in immune response (GO:0002312)	2.90168629
51	positive regulation of fatty acid transport (GO:2000193)	2.90152198
52	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.89576100
53	positive regulation of lymphocyte migration (GO:2000403)	2.87358956
54	DNA methylation involved in gamete generation (GO:0043046)	2.86260121
55	regulation of isotype switching (GO:0045191)	2.81830167
56	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.80568365
57	water-soluble vitamin biosynthetic process (GO:0042364)	2.80206207
58	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.80178522
59	negative regulation of mast cell activation (GO:0033004)	2.77144083
60	fucose catabolic process (GO:0019317)	2.74663365
61	L-fucose metabolic process (GO:0042354)	2.74663365
62	L-fucose catabolic process (GO:0042355)	2.74663365
63	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.74067325
64	positive regulation of B cell mediated immunity (GO:0002714)	2.74067325
65	positive regulation of T-helper 1 type immune response (GO:0002827)	2.73899450
66	protein complex biogenesis (GO:0070271)	2.71797648
67	response to pheromone (GO:0019236)	2.69328881
68	natural killer cell activation (GO:0030101)	2.68708953
69	termination of RNA polymerase III transcription (GO:0006386)	2.68405358
70	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.68405358
71	regulation of translational elongation (GO:0006448)	2.68341558
72	cytidine metabolic process (GO:0046087)	2.67972838
73	cytidine catabolic process (GO:0006216)	2.67972838
74	cytidine deamination (GO:0009972)	2.67972838
75	regulation of interleukin-17 production (GO:0032660)	2.66502083
76	protein K6-linked ubiquitination (GO:0085020)	2.62421387
77	response to xenobiotic stimulus (GO:0009410)	2.62097377
78	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.60224317
79	T-helper cell differentiation (GO:0042093)	2.60224317
80	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.57631177
81	tRNA processing (GO:0008033)	2.57456952
82	regulation of activated T cell proliferation (GO:0046006)	2.55296178
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.52445031
84	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51925675
85	negative regulation of telomere maintenance (GO:0032205)	2.50419408
86	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.49626458
87	positive regulation of interferon-gamma production (GO:0032729)	2.49395302
88	regulation of translational termination (GO:0006449)	2.49345423
89	positive regulation of icosanoid secretion (GO:0032305)	2.49039874
90	antigen processing and presentation via MHC class Ib (GO:0002475)	2.46016604
91	regulation of prostaglandin secretion (GO:0032306)	2.45763650
92	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.45475929
93	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.45475929
94	negative regulation of T cell differentiation in thymus (GO:0033085)	2.45392079
95	nucleotide transmembrane transport (GO:1901679)	2.45369636
96	DNA replication checkpoint (GO:0000076)	2.45041755
97	cellular response to interleukin-15 (GO:0071350)	2.44643810
98	negative regulation of heart rate (GO:0010459)	2.44176617
99	ribosome biogenesis (GO:0042254)	2.42961106
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42381562

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.27664375
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.48014574
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.46589608
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.19103977
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.87789599
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.79979197
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.77122588
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73755624
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.68090686
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.66661651
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.60546954
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.54235322
13	VDR_22108803_ChIP-Seq_LS180_Human	2.51901962
14	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.41916248
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.40904779
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33295474
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.32445952
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.22447636
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.20900284
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15350600
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14554527
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10060854
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00660061
24	GATA3_26560356_Chip-Seq_TH2_Human	1.98995405
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.96022129
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94303923
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.91147119
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86505227
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83717856
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76470291
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74207144
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.72966171
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68491481
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63152386
35	EWS_26573619_Chip-Seq_HEK293_Human	1.57948435
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52960637
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50890357
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49681050
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.46842612
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45968213
41	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.43667287
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.43252834
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42459396
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42459396
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.40973295
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40365890
47	AR_20517297_ChIP-Seq_VCAP_Human	1.39668437
48	MYB_26560356_Chip-Seq_TH2_Human	1.38592423
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33470200
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32166047
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.29607773
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25547434
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25523080
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24383667
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22426226
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22221606
57	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.21943647
58	GATA3_27048872_Chip-Seq_THYMUS_Human	1.20699523
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18750863
60	STAT1_20625510_ChIP-Seq_HELA_Human	1.16648105
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.16626816
62	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14481517
63	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13819944
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13478816
65	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.13142994
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13104258
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11966595
68	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11955514
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08792407
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07330926
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.07247103
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06627285
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.06627285
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.06097896
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05966084
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05058065
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03433739
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03313479
79	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03309185
80	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02933873
81	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.02465988
82	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99497647
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98515247
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96940810
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96940810
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96363794
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.95229700
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.93789019
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.90408828
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88591559
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87315862
92	NCOR_22424771_ChIP-Seq_293T_Human	0.87177160
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.87148213
94	TTF2_22483619_ChIP-Seq_HELA_Human	0.87087964
95	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.87051921
96	P300_19829295_ChIP-Seq_ESCs_Human	0.86710671
97	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.86464115
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86184504
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86058571
100	IGF1R_20145208_ChIP-Seq_DFB_Human	0.86033152

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.94159171
2	MP0005075_abnormal_melanosome_morpholog	3.80043202
3	MP0005671_abnormal_response_to	3.33333403
4	MP0000685_abnormal_immune_system	3.20647660
5	MP0001790_abnormal_immune_system	2.65527182
6	MP0005387_immune_system_phenotype	2.65527182
7	MP0002148_abnormal_hypersensitivity_rea	2.47744728
8	MP0001853_heart_inflammation	2.41135621
9	MP0003300_gastrointestinal_ulcer	2.33085990
10	MP0001800_abnormal_humoral_immune	2.29765094
11	MP0005000_abnormal_immune_tolerance	2.18542741
12	MP0008875_abnormal_xenobiotic_pharmacok	2.14180436
13	MP0000604_amyloidosis	2.09977886
14	MP0008872_abnormal_physiological_respon	2.01840607
15	MP0001661_extended_life_span	1.88299118
16	MP0001919_abnormal_reproductive_system	1.88117455
17	MP0001986_abnormal_taste_sensitivity	1.87570689
18	MP0002723_abnormal_immune_serum	1.79945693
19	MP0000372_irregular_coat_pigmentation	1.79450979
20	MP0003195_calcinosis	1.76270003
21	MP0001968_abnormal_touch/_nociception	1.75007123
22	MP0002452_abnormal_antigen_presenting	1.70769722
23	MP0005389_reproductive_system_phenotype	1.69486683
24	MP0009333_abnormal_splenocyte_physiolog	1.68114306
25	MP0002420_abnormal_adaptive_immunity	1.65096244
26	MP0001819_abnormal_immune_cell	1.64085470
27	MP0002736_abnormal_nociception_after	1.60296121
28	MP0003646_muscle_fatigue	1.57709083
29	MP0003866_abnormal_defecation	1.56466887
30	MP0003763_abnormal_thymus_physiology	1.55764334
31	MP0004145_abnormal_muscle_electrophysio	1.53777821
32	MP0002234_abnormal_pharynx_morphology	1.51476491
33	MP0006072_abnormal_retinal_apoptosis	1.48808644
34	MP0004782_abnormal_surfactant_physiolog	1.48060086
35	MP0006035_abnormal_mitochondrial_morpho	1.48024795
36	MP0009697_abnormal_copulation	1.45139664
37	MP0002006_tumorigenesis	1.44451231
38	MP0005174_abnormal_tail_pigmentation	1.43777681
39	MP0000569_abnormal_digit_pigmentation	1.43613049
40	MP0000465_gastrointestinal_hemorrhage	1.40048843
41	MP0004043_abnormal_pH_regulation	1.39069239
42	MP0002166_altered_tumor_susceptibility	1.38808804
43	MP0009785_altered_susceptibility_to	1.37614868
44	MP0003786_premature_aging	1.32935482
45	MP0005367_renal/urinary_system_phenotyp	1.27994971
46	MP0000516_abnormal_urinary_system	1.27994971
47	MP0009046_muscle_twitch	1.23331076
48	MP0006036_abnormal_mitochondrial_physio	1.22839464
49	MP0002837_dystrophic_cardiac_calcinosis	1.20626146
50	MP0010386_abnormal_urinary_bladder	1.19136343
51	MP0005360_urolithiasis	1.18710089
52	MP0002405_respiratory_system_inflammati	1.17709942
53	MP0005025_abnormal_response_to	1.17268727
54	MP0001845_abnormal_inflammatory_respons	1.16051632
55	MP0006082_CNS_inflammation	1.15367985
56	MP0005410_abnormal_fertilization	1.13207211
57	MP0002398_abnormal_bone_marrow	1.13142683
58	MP0010155_abnormal_intestine_physiology	1.11176082
59	MP0002102_abnormal_ear_morphology	1.10912740
60	MP0000689_abnormal_spleen_morphology	1.10549009
61	MP0008877_abnormal_DNA_methylation	1.10505361
62	MP0003045_fibrosis	1.10277261
63	MP0002722_abnormal_immune_system	1.09811762
64	MP0000716_abnormal_immune_system	1.08917691
65	MP0004084_abnormal_cardiac_muscle	1.07941253
66	MP0002876_abnormal_thyroid_physiology	1.07212992
67	MP0003806_abnormal_nucleotide_metabolis	1.04986569
68	MP0001501_abnormal_sleep_pattern	1.04080586
69	MP0000427_abnormal_hair_cycle	1.03801900
70	MP0008007_abnormal_cellular_replicative	1.00478034
71	MP0001765_abnormal_ion_homeostasis	1.00466502
72	MP0004381_abnormal_hair_follicle	0.99989387
73	MP0003724_increased_susceptibility_to	0.99123875
74	MP0005636_abnormal_mineral_homeostasis	0.97930331
75	MP0009764_decreased_sensitivity_to	0.97028979
76	MP0003329_amyloid_beta_deposits	0.96493229
77	MP0001873_stomach_inflammation	0.96023357
78	MP0005646_abnormal_pituitary_gland	0.95792492
79	MP0002160_abnormal_reproductive_system	0.94474320
80	MP0004142_abnormal_muscle_tone	0.93203216
81	MP0003693_abnormal_embryo_hatching	0.91834699
82	MP0009379_abnormal_foot_pigmentation	0.91327685
83	MP0002272_abnormal_nervous_system	0.89771303
84	MP0002429_abnormal_blood_cell	0.86795018
85	MP0002693_abnormal_pancreas_physiology	0.84747288
86	MP0009745_abnormal_behavioral_response	0.83941801
87	MP0003718_maternal_effect	0.83629132
88	MP0009053_abnormal_anal_canal	0.82753082
89	MP0005551_abnormal_eye_electrophysiolog	0.82724628
90	MP0001440_abnormal_grooming_behavior	0.82120567
91	MP0000703_abnormal_thymus_morphology	0.80793906
92	MP0005332_abnormal_amino_acid	0.79393162
93	MP0001764_abnormal_homeostasis	0.77181052
94	MP0000371_diluted_coat_color	0.76630806
95	MP0002419_abnormal_innate_immunity	0.74472999
96	MP0003186_abnormal_redox_activity	0.73754413
97	MP0005464_abnormal_platelet_physiology	0.72489741
98	MP0003011_delayed_dark_adaptation	0.71091884
99	MP0001881_abnormal_mammary_gland	0.70638471
100	MP0002019_abnormal_tumor_incidence	0.69560793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.28390400
2	Congenital, generalized hypertrichosis (HP:0004540)	5.09890945
3	Stomatitis (HP:0010280)	4.99546170
4	IgG deficiency (HP:0004315)	4.91700742
5	Abnormality of B cell number (HP:0010975)	4.17000296
6	B lymphocytopenia (HP:0010976)	4.07573620
7	Increased IgM level (HP:0003496)	3.98477720
8	Hepatocellular necrosis (HP:0001404)	3.48500930
9	Hypoproteinemia (HP:0003075)	3.48149060
10	IgA deficiency (HP:0002720)	3.36382068
11	Abolished electroretinogram (ERG) (HP:0000550)	3.27303094
12	Parakeratosis (HP:0001036)	3.20125446
13	IgM deficiency (HP:0002850)	3.14907405
14	Mitochondrial inheritance (HP:0001427)	3.13190735
15	Type II lissencephaly (HP:0007260)	3.12965378
16	Adactyly (HP:0009776)	2.97012487
17	Hepatic necrosis (HP:0002605)	2.95671678
18	Chronic hepatic failure (HP:0100626)	2.93522698
19	Abnormality of T cell physiology (HP:0011840)	2.93375698
20	Increased CSF lactate (HP:0002490)	2.89349698
21	Pancreatic cysts (HP:0001737)	2.76855448
22	Hypoplasia of the pons (HP:0012110)	2.74327202
23	Congenital stationary night blindness (HP:0007642)	2.67054753
24	Increased hepatocellular lipid droplets (HP:0006565)	2.66814601
25	Abnormality of the pons (HP:0007361)	2.65288886
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65195055
27	Abnormality of alanine metabolism (HP:0010916)	2.64361225
28	Hyperalaninemia (HP:0003348)	2.64361225
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64361225
30	Abnormal number of erythroid precursors (HP:0012131)	2.62734802
31	Absent thumb (HP:0009777)	2.55624760
32	Thyroiditis (HP:0100646)	2.52993586
33	Acute necrotizing encephalopathy (HP:0006965)	2.49548669
34	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.46864513
35	Abnormality of T cells (HP:0002843)	2.43855578
36	Lipid accumulation in hepatocytes (HP:0006561)	2.43182333
37	Increased intramyocellular lipid droplets (HP:0012240)	2.42938952
38	Increased corneal curvature (HP:0100692)	2.41990416
39	Keratoconus (HP:0000563)	2.41990416
40	Methylmalonic acidemia (HP:0002912)	2.40422871
41	Methylmalonic aciduria (HP:0012120)	2.38954571
42	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.36253265
43	Type 2 muscle fiber atrophy (HP:0003554)	2.35276545
44	Distal arthrogryposis (HP:0005684)	2.32269855
45	Progressive macrocephaly (HP:0004481)	2.29520302
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.25007321
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.25007321
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.24281940
49	Dyschromatopsia (HP:0007641)	2.23057960
50	Cerebellar dysplasia (HP:0007033)	2.21360348
51	Molar tooth sign on MRI (HP:0002419)	2.20464206
52	Abnormality of midbrain morphology (HP:0002418)	2.20464206
53	Severe combined immunodeficiency (HP:0004430)	2.17011153
54	Exertional dyspnea (HP:0002875)	2.15398439
55	Microvesicular hepatic steatosis (HP:0001414)	2.12293776
56	Muscle fiber atrophy (HP:0100295)	2.11233881
57	Abnormal biliary tract physiology (HP:0012439)	2.10537873
58	Bile duct proliferation (HP:0001408)	2.10537873
59	Increased serum lactate (HP:0002151)	2.09435746
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.09256700
61	Pancreatic fibrosis (HP:0100732)	2.07918671
62	Fibular aplasia (HP:0002990)	2.05528579
63	Erythroderma (HP:0001019)	2.04969825
64	Eosinophilia (HP:0001880)	2.03421706
65	CNS demyelination (HP:0007305)	2.02889375
66	Amelogenesis imperfecta (HP:0000705)	2.02165865
67	Acute encephalopathy (HP:0006846)	2.01905850
68	Radial bowing (HP:0002986)	2.01332001
69	Emotional lability (HP:0000712)	2.00589523
70	Abnormal finger flexion creases (HP:0006143)	1.99256878
71	Partial agenesis of the corpus callosum (HP:0001338)	1.98057076
72	Increased muscle lipid content (HP:0009058)	1.97959956
73	Lactic acidosis (HP:0003128)	1.97116299
74	Premature ovarian failure (HP:0008209)	1.96923605
75	Renal cortical cysts (HP:0000803)	1.90764764
76	Posterior subcapsular cataract (HP:0007787)	1.89388605
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88875839
78	Abnormality of the prostate (HP:0008775)	1.88756079
79	Autoimmune thrombocytopenia (HP:0001973)	1.88329472
80	Pendular nystagmus (HP:0012043)	1.85674712
81	Cerebral edema (HP:0002181)	1.84323156
82	True hermaphroditism (HP:0010459)	1.82825310
83	Hypomagnesemia (HP:0002917)	1.81935876
84	Pustule (HP:0200039)	1.81814803
85	Abnormality of eosinophils (HP:0001879)	1.79649362
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78398140
87	Abnormal drinking behavior (HP:0030082)	1.77626794
88	Polydipsia (HP:0001959)	1.77626794
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77511516
90	Nephronophthisis (HP:0000090)	1.76341870
91	Recurrent fungal infections (HP:0002841)	1.74928057
92	Optic disc pallor (HP:0000543)	1.73922927
93	Sclerocornea (HP:0000647)	1.73491979
94	Recurrent bronchitis (HP:0002837)	1.72105178
95	Colon cancer (HP:0003003)	1.71894660
96	Abnormality of the renal cortex (HP:0011035)	1.71449161
97	Patellar aplasia (HP:0006443)	1.70523457
98	Aplasia/Hypoplasia of the patella (HP:0006498)	1.70407025
99	Abnormal rod and cone electroretinograms (HP:0008323)	1.69416218
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68925991

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.76569737
2	STK16	4.67798602
3	NME1	4.14259524
4	TXK	2.96246039
5	MUSK	2.96077599
6	TRIM28	2.73845403
7	MAPKAPK3	2.45277304
8	TLK1	2.44215405
9	ACVR1B	2.40374342
10	ZAK	2.39383374
11	BMPR1B	2.33666314
12	GRK1	2.31821062
13	ITK	2.22942426
14	WNK4	2.09425169
15	TAOK3	2.06203165
16	ADRBK2	2.02148271
17	EIF2AK3	1.88237845
18	MAP3K13	1.85911671
19	SIK3	1.81172129
20	BCKDK	1.77839202
21	EIF2AK1	1.76875016
22	PHKG2	1.74041183
23	PHKG1	1.74041183
24	STK39	1.65720841
25	OXSR1	1.61048775
26	TEC	1.54741630
27	NUAK1	1.49501865
28	PINK1	1.48984610
29	PIK3CG	1.45352728
30	CSNK1G1	1.37745143
31	CSNK1G3	1.30505596
32	VRK2	1.20124001
33	MST4	1.18051593
34	MAP3K9	1.13558833
35	CSNK1G2	1.12663909
36	PLK4	1.09809787
37	CSNK1A1L	1.07798041
38	PRKCI	1.06788321
39	PLK2	1.00965082
40	EIF2AK2	0.98469422
41	IKBKB	0.96656451
42	SYK	0.92915029
43	BCR	0.90209473
44	MAP4K2	0.86022473
45	RPS6KB2	0.85083547
46	CSK	0.78507061
47	ERBB3	0.75099899
48	MAPKAPK5	0.67082933
49	PLK3	0.67021735
50	FGFR2	0.64295230
51	INSRR	0.63908698
52	TRPM7	0.60990454
53	KIT	0.59983753
54	NLK	0.59354470
55	IKBKE	0.58193086
56	VRK1	0.57789347
57	PDK2	0.57774334
58	TNIK	0.56708109
59	PRKCQ	0.55298794
60	BMPR2	0.53825298
61	MAP3K4	0.53626775
62	MKNK2	0.52834266
63	LYN	0.52221725
64	LCK	0.51583674
65	KDR	0.50635295
66	DAPK2	0.50403453
67	CAMKK2	0.50330034
68	EEF2K	0.48936074
69	ARAF	0.48623316
70	TAF1	0.47817433
71	CHEK2	0.44783731
72	MAP2K7	0.42348955
73	MAP4K1	0.41333787
74	WNK3	0.38693142
75	MINK1	0.37802386
76	MAPK11	0.37555793
77	ADRBK1	0.35649948
78	CSNK1A1	0.34975869
79	TGFBR1	0.34820486
80	RPS6KA5	0.34815312
81	PIK3CA	0.33619840
82	MAPK13	0.33131198
83	CHUK	0.32523324
84	HCK	0.32268052
85	MAP2K2	0.31848947
86	PAK4	0.31719863
87	PRKCE	0.31716034
88	BTK	0.30540244
89	BUB1	0.29082075
90	KSR1	0.28959180
91	MAP2K6	0.28695213
92	PLK1	0.28640630
93	RIPK4	0.26123705
94	MAP3K14	0.25626153
95	PRKCD	0.24398303
96	MYLK	0.22719632
97	PRKCA	0.22030259
98	DAPK1	0.21984201
99	PRKCG	0.21111999
100	IRAK1	0.20927679

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	4.59163317
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.34595126
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.31915537
4	Graft-versus-host disease_Homo sapiens_hsa05332	4.08251080
5	Asthma_Homo sapiens_hsa05310	3.88951763
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.17029151
7	Protein export_Homo sapiens_hsa03060	2.86815347
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.85548569
9	Proteasome_Homo sapiens_hsa03050	2.78949251
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.51679402
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44138973
12	RNA polymerase_Homo sapiens_hsa03020	2.23907670
13	Ribosome_Homo sapiens_hsa03010	2.20479126
14	Parkinsons disease_Homo sapiens_hsa05012	1.87118002
15	Homologous recombination_Homo sapiens_hsa03440	1.81819828
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.81812660
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.64911839
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.63504047
19	Basal transcription factors_Homo sapiens_hsa03022	1.51271778
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.35854277
21	Caffeine metabolism_Homo sapiens_hsa00232	1.32296917
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31637653
23	Alzheimers disease_Homo sapiens_hsa05010	1.28753905
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28388911
25	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.22837852
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.19938052
27	Huntingtons disease_Homo sapiens_hsa05016	1.19562599
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19555362
29	Viral myocarditis_Homo sapiens_hsa05416	1.18805304
30	RNA degradation_Homo sapiens_hsa03018	1.16983810
31	Mismatch repair_Homo sapiens_hsa03430	1.14148153
32	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.12519515
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.11890304
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07963394
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07879746
36	Phototransduction_Homo sapiens_hsa04744	1.07620902
37	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99514534
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99348235
39	Nucleotide excision repair_Homo sapiens_hsa03420	0.93338861
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89838895
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87150456
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86546438
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84631348
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83158992
45	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.79177479
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.78942109
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75259172
48	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.74858182
49	RNA transport_Homo sapiens_hsa03013	0.74551739
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74545768
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.65951803
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62649496
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.61930346
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61187761
55	One carbon pool by folate_Homo sapiens_hsa00670	0.60349106
56	Sulfur metabolism_Homo sapiens_hsa00920	0.59436731
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.58412516
58	DNA replication_Homo sapiens_hsa03030	0.58344977
59	Propanoate metabolism_Homo sapiens_hsa00640	0.56301626
60	Purine metabolism_Homo sapiens_hsa00230	0.53005455
61	Spliceosome_Homo sapiens_hsa03040	0.51920694
62	Sulfur relay system_Homo sapiens_hsa04122	0.48934974
63	Taste transduction_Homo sapiens_hsa04742	0.48897887
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48831921
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48372691
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.47458442
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40227728
68	Nicotine addiction_Homo sapiens_hsa05033	0.36579102
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34699783
70	African trypanosomiasis_Homo sapiens_hsa05143	0.34334314
71	Measles_Homo sapiens_hsa05162	0.34139051
72	Folate biosynthesis_Homo sapiens_hsa00790	0.33989328
73	Peroxisome_Homo sapiens_hsa04146	0.33532595
74	Retinol metabolism_Homo sapiens_hsa00830	0.33258301
75	Olfactory transduction_Homo sapiens_hsa04740	0.31428349
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31116698
77	Serotonergic synapse_Homo sapiens_hsa04726	0.29767522
78	Mineral absorption_Homo sapiens_hsa04978	0.29429548
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29382559
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28486345
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27646647
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26833018
83	Herpes simplex infection_Homo sapiens_hsa05168	0.26138860
84	Morphine addiction_Homo sapiens_hsa05032	0.24388797
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22986221
86	Metabolic pathways_Homo sapiens_hsa01100	0.22821553
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.22455152
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21592816
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.21025360
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20944288
91	Base excision repair_Homo sapiens_hsa03410	0.20052044
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.19624078
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.18943319
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.18643073
95	p53 signaling pathway_Homo sapiens_hsa04115	0.18299705
96	Leishmaniasis_Homo sapiens_hsa05140	0.16693576
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.16689183
98	Apoptosis_Homo sapiens_hsa04210	0.16292921
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.15985594
100	TNF signaling pathway_Homo sapiens_hsa04668	0.11466575

RPL23AP31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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