ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurofilament cytoskeleton organization (GO:0060052)	6.40627954
2	regulation of protein glycosylation (GO:0060049)	6.17840498
3	glyoxylate metabolic process (GO:0046487)	5.15416991
4	ribosomal small subunit assembly (GO:0000028)	4.46551794
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.25269535
6	chaperone-mediated protein transport (GO:0072321)	4.22867594
7	male meiosis (GO:0007140)	4.14887860
8	regulation of DNA methylation (GO:0044030)	4.11574290
9	activated T cell proliferation (GO:0050798)	3.87716162
10	ectoderm development (GO:0007398)	3.86595222
11	mast cell activation (GO:0045576)	3.69394985
12	negative regulation of telomere maintenance (GO:0032205)	3.67660759
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.60080912
14	negative regulation of mast cell activation (GO:0033004)	3.45612589
15	protein-cofactor linkage (GO:0018065)	3.43572081
16	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.34145248
17	cellular response to interleukin-15 (GO:0071350)	3.25863807
18	indolalkylamine metabolic process (GO:0006586)	3.25799226
19	L-methionine biosynthetic process (GO:0071265)	3.23209929
20	amino acid salvage (GO:0043102)	3.23209929
21	L-methionine salvage (GO:0071267)	3.23209929
22	indole-containing compound catabolic process (GO:0042436)	3.23121506
23	indolalkylamine catabolic process (GO:0046218)	3.23121506
24	tryptophan catabolic process (GO:0006569)	3.23121506
25	cell wall macromolecule catabolic process (GO:0016998)	3.22314583
26	xenobiotic catabolic process (GO:0042178)	3.17754708
27	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.17246012
28	tryptophan metabolic process (GO:0006568)	3.17168441
29	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.16974701
30	regulation of natural killer cell mediated immunity (GO:0002715)	3.16974701
31	L-fucose catabolic process (GO:0042355)	3.10823557
32	fucose catabolic process (GO:0019317)	3.10823557
33	L-fucose metabolic process (GO:0042354)	3.10823557
34	negative regulation of cation channel activity (GO:2001258)	3.09133067
35	cellular biogenic amine catabolic process (GO:0042402)	3.05286883
36	amine catabolic process (GO:0009310)	3.05286883
37	protein polyglutamylation (GO:0018095)	3.01121503
38	coenzyme catabolic process (GO:0009109)	2.98931991
39	regulation of interleukin-8 secretion (GO:2000482)	2.97106514
40	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.89441580
41	cell wall macromolecule metabolic process (GO:0044036)	2.88651047
42	female gonad development (GO:0008585)	2.86434353
43	acrosome assembly (GO:0001675)	2.85764690
44	ubiquinone biosynthetic process (GO:0006744)	2.85455556
45	aggressive behavior (GO:0002118)	2.85028749
46	S-adenosylmethionine metabolic process (GO:0046500)	2.82499523
47	sleep (GO:0030431)	2.81978572
48	positive regulation of glycoprotein metabolic process (GO:1903020)	2.79200070
49	piRNA metabolic process (GO:0034587)	2.78713363
50	DNA deamination (GO:0045006)	2.76685605
51	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.74976429
52	cellular ketone body metabolic process (GO:0046950)	2.71157506
53	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.69879182
54	tyrosine phosphorylation of STAT protein (GO:0007260)	2.67655147
55	rRNA catabolic process (GO:0016075)	2.66704473
56	retinal cone cell development (GO:0046549)	2.64099203
57	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.62114051
58	epithelial cilium movement (GO:0003351)	2.60843107
59	inner mitochondrial membrane organization (GO:0007007)	2.60801576
60	thyroid hormone generation (GO:0006590)	2.60546015
61	ketone body metabolic process (GO:1902224)	2.58114081
62	negative regulation of heart rate (GO:0010459)	2.56287524
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55961571
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.55432901
65	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.55191067
66	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.55191067
67	RNA destabilization (GO:0050779)	2.54222726
68	sulfation (GO:0051923)	2.52724985
69	mast cell activation involved in immune response (GO:0002279)	2.50697682
70	mast cell degranulation (GO:0043303)	2.50697682
71	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.50051682
72	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.50051682
73	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.50049016
74	multicellular organism reproduction (GO:0032504)	2.49883862
75	nonmotile primary cilium assembly (GO:0035058)	2.49754000
76	adenosine metabolic process (GO:0046085)	2.49591431
77	ubiquinone metabolic process (GO:0006743)	2.49537133
78	transcription from RNA polymerase I promoter (GO:0006360)	2.48808334
79	ATP synthesis coupled proton transport (GO:0015986)	2.47303186
80	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.47303186
81	metallo-sulfur cluster assembly (GO:0031163)	2.47227492
82	iron-sulfur cluster assembly (GO:0016226)	2.47227492
83	quinone biosynthetic process (GO:1901663)	2.46607003
84	regulation of telomere maintenance via telomerase (GO:0032210)	2.45380480
85	fatty acid transmembrane transport (GO:1902001)	2.44575055
86	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.40819706
87	rhodopsin mediated signaling pathway (GO:0016056)	2.39326112
88	kynurenine metabolic process (GO:0070189)	2.38051989
89	regulation of germinal center formation (GO:0002634)	2.36721357
90	indole-containing compound metabolic process (GO:0042430)	2.36691430
91	regulation of penile erection (GO:0060405)	2.36656486
92	neutrophil activation (GO:0042119)	2.36637547
93	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.35648852
94	behavioral response to nicotine (GO:0035095)	2.35277385
95	protein heterotetramerization (GO:0051290)	2.34421473
96	benzene-containing compound metabolic process (GO:0042537)	2.33718069
97	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.32744274
98	maintenance of protein location in nucleus (GO:0051457)	2.30892726
99	response to interleukin-15 (GO:0070672)	2.30651463
100	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.30428490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.72733982
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.49716505
3	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.42639856
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.24375095
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.20276479
6	VDR_22108803_ChIP-Seq_LS180_Human	3.10620036
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.92647598
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91440171
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88298778
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.86121611
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.82568146
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.37376663
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.25812251
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.25051408
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.01212089
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.01212089
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97378231
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97099436
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86520784
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82806037
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.78095326
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67476290
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66470596
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64881152
25	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.61454091
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60808986
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.60646024
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55874292
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55091238
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53489378
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51491652
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50138142
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.49689605
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.48092354
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47993910
36	RUNX_20019798_ChIP-Seq_JUKART_Human	1.46478662
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45837355
38	GATA3_26560356_Chip-Seq_TH2_Human	1.42590670
39	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.40956709
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36274937
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34017488
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32882371
43	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32117638
44	FUS_26573619_Chip-Seq_HEK293_Human	1.30766883
45	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.29097710
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26313750
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25691705
48	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24858348
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24749805
50	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24030641
51	MYB_26560356_Chip-Seq_TH2_Human	1.23664384
52	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.23272219
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21648897
54	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.21177002
55	EWS_26573619_Chip-Seq_HEK293_Human	1.18875518
56	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.17847043
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.17324907
58	P300_19829295_ChIP-Seq_ESCs_Human	1.16462116
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.16321704
60	GATA3_27048872_Chip-Seq_THYMUS_Human	1.14951732
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14652243
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12725122
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12725122
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12601455
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12406296
66	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.11603359
67	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.10764476
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10488459
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09444337
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08973308
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08521076
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08460709
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07007703
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06949589
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.05813706
76	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.01941801
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01774701
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01058593
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.00984938
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95850571
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94256306
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94256306
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93229340
84	TCF4_23295773_ChIP-Seq_U87_Human	0.92709027
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91361163
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90799058
87	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.90375390
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.90238684
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89420052
90	AR_25329375_ChIP-Seq_VCAP_Human	0.89332457
91	NCOR_22424771_ChIP-Seq_293T_Human	0.88863612
92	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.88523602
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.87836136
94	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.87790190
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.87207844
96	AR_20517297_ChIP-Seq_VCAP_Human	0.87201663
97	EZH2_22144423_ChIP-Seq_EOC_Human	0.87001252
98	TP53_16413492_ChIP-PET_HCT116_Human	0.86795771
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.84944913
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84921044

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	4.57691834
2	MP0005671_abnormal_response_to	3.31228465
3	MP0001986_abnormal_taste_sensitivity	3.07792270
4	MP0003806_abnormal_nucleotide_metabolis	2.75786088
5	MP0008875_abnormal_xenobiotic_pharmacok	2.71714815
6	MP0006072_abnormal_retinal_apoptosis	2.60598975
7	MP0001835_abnormal_antigen_presentation	2.49577566
8	MP0003646_muscle_fatigue	2.36498328
9	MP0002876_abnormal_thyroid_physiology	2.35034846
10	MP0005253_abnormal_eye_physiology	2.26293182
11	MP0006082_CNS_inflammation	2.20337008
12	MP0003786_premature_aging	2.14063165
13	MP0003763_abnormal_thymus_physiology	2.13728985
14	MP0003724_increased_susceptibility_to	2.03023493
15	MP0006276_abnormal_autonomic_nervous	1.98310787
16	MP0005171_absent_coat_pigmentation	1.81730146
17	MP0001905_abnormal_dopamine_level	1.80885430
18	MP0003880_abnormal_central_pattern	1.80291269
19	MP0005646_abnormal_pituitary_gland	1.74462024
20	MP0002653_abnormal_ependyma_morphology	1.74212934
21	MP0001800_abnormal_humoral_immune	1.74029559
22	MP0001529_abnormal_vocalization	1.73099870
23	MP0004885_abnormal_endolymph	1.71943200
24	MP0005000_abnormal_immune_tolerance	1.71937626
25	MP0002638_abnormal_pupillary_reflex	1.67204879
26	MP0005551_abnormal_eye_electrophysiolog	1.66560524
27	MP0002723_abnormal_immune_serum	1.55125843
28	MP0003195_calcinosis	1.52345264
29	MP0002933_joint_inflammation	1.50582267
30	MP0005025_abnormal_response_to	1.50112351
31	MP0002095_abnormal_skin_pigmentation	1.46752387
32	MP0000372_irregular_coat_pigmentation	1.46561909
33	MP0008789_abnormal_olfactory_epithelium	1.41656473
34	MP0009785_altered_susceptibility_to	1.41451692
35	MP0002938_white_spotting	1.40163871
36	MP0001968_abnormal_touch/_nociception	1.32091914
37	MP0002148_abnormal_hypersensitivity_rea	1.32086334
38	MP0002837_dystrophic_cardiac_calcinosis	1.30779878
39	MP0005075_abnormal_melanosome_morpholog	1.28465972
40	MP0002420_abnormal_adaptive_immunity	1.26713955
41	MP0009046_muscle_twitch	1.25914181
42	MP0004043_abnormal_pH_regulation	1.25368053
43	MP0001984_abnormal_olfaction	1.24359904
44	MP0001819_abnormal_immune_cell	1.23210188
45	MP0004484_altered_response_of	1.22645270
46	MP0006292_abnormal_olfactory_placode	1.21671968
47	MP0005360_urolithiasis	1.21548297
48	MP0001501_abnormal_sleep_pattern	1.21493975
49	MP0001486_abnormal_startle_reflex	1.19581256
50	MP0003718_maternal_effect	1.19376986
51	MP0008872_abnormal_physiological_respon	1.18224732
52	MP0002452_abnormal_antigen_presenting	1.17848704
53	MP0001851_eye_inflammation	1.15196417
54	MP0005394_taste/olfaction_phenotype	1.15008636
55	MP0005499_abnormal_olfactory_system	1.15008636
56	MP0001873_stomach_inflammation	1.13552411
57	MP0005645_abnormal_hypothalamus_physiol	1.13432510
58	MP0000465_gastrointestinal_hemorrhage	1.12264641
59	MP0005387_immune_system_phenotype	1.08728749
60	MP0001790_abnormal_immune_system	1.08728749
61	MP0008775_abnormal_heart_ventricle	1.08189122
62	MP0010386_abnormal_urinary_bladder	1.07886800
63	MP0002419_abnormal_innate_immunity	1.07834350
64	MP0004147_increased_porphyrin_level	1.06244159
65	MP0000685_abnormal_immune_system	1.05160650
66	MP0002102_abnormal_ear_morphology	1.02509212
67	MP0004145_abnormal_muscle_electrophysio	0.98593517
68	MP0006036_abnormal_mitochondrial_physio	0.94570007
69	MP0000716_abnormal_immune_system	0.94198116
70	MP0003011_delayed_dark_adaptation	0.94115540
71	MP0006054_spinal_hemorrhage	0.93842289
72	MP0004142_abnormal_muscle_tone	0.93789535
73	MP0001853_heart_inflammation	0.93681663
74	MP0003866_abnormal_defecation	0.92598046
75	MP0000230_abnormal_systemic_arterial	0.92434517
76	MP0009764_decreased_sensitivity_to	0.92395156
77	MP0002398_abnormal_bone_marrow	0.90669576
78	MP0006035_abnormal_mitochondrial_morpho	0.90398443
79	MP0005174_abnormal_tail_pigmentation	0.88878927
80	MP0009333_abnormal_splenocyte_physiolog	0.86065679
81	MP0001845_abnormal_inflammatory_respons	0.83334327
82	MP0001502_abnormal_circadian_rhythm	0.82972007
83	MP0008873_increased_physiological_sensi	0.81223136
84	MP0002736_abnormal_nociception_after	0.80828907
85	MP0003186_abnormal_redox_activity	0.77862334
86	MP0005423_abnormal_somatic_nervous	0.76298677
87	MP0009745_abnormal_behavioral_response	0.75679048
88	MP0002405_respiratory_system_inflammati	0.74464802
89	MP0008469_abnormal_protein_level	0.73770320
90	MP0004947_skin_inflammation	0.73151045
91	MP0001119_abnormal_female_reproductive	0.72873146
92	MP0005410_abnormal_fertilization	0.72844826
93	MP0005391_vision/eye_phenotype	0.72457854
94	MP0008058_abnormal_DNA_repair	0.71228541
95	MP0002722_abnormal_immune_system	0.70939246
96	MP0008877_abnormal_DNA_methylation	0.69348659
97	MP0002429_abnormal_blood_cell	0.69100213
98	MP0002277_abnormal_respiratory_mucosa	0.68743407
99	MP0000689_abnormal_spleen_morphology	0.68428388
100	MP0004924_abnormal_behavior	0.67435978

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	5.06500275
2	Abnormality of the renal collecting system (HP:0004742)	4.98023526
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.48690204
4	Reticulocytopenia (HP:0001896)	4.42052403
5	Abnormality of DNA repair (HP:0003254)	4.21706522
6	Aplastic anemia (HP:0001915)	4.18781890
7	Eosinophilia (HP:0001880)	4.03077240
8	Chromsome breakage (HP:0040012)	3.90495985
9	Abnormality of B cell number (HP:0010975)	3.86810996
10	Recurrent gram-negative bacterial infections (HP:0005420)	3.83594448
11	Abnormality of pyrimidine metabolism (HP:0004353)	3.72200663
12	Abnormality of eosinophils (HP:0001879)	3.65456376
13	Leukocytosis (HP:0001974)	3.59142171
14	Autoimmune thrombocytopenia (HP:0001973)	3.54470921
15	Increased IgM level (HP:0003496)	3.42391914
16	Abnormality of T cell number (HP:0011839)	3.41226881
17	Autoimmune hemolytic anemia (HP:0001890)	3.41188928
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.27728079
19	Renal cortical cysts (HP:0000803)	3.03947316
20	Abolished electroretinogram (ERG) (HP:0000550)	3.01023092
21	Granulocytopenia (HP:0001913)	2.99701687
22	Pancytopenia (HP:0001876)	2.94685570
23	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.90422205
24	Hypoproteinemia (HP:0003075)	2.87559221
25	Lipid accumulation in hepatocytes (HP:0006561)	2.83586869
26	Absent thumb (HP:0009777)	2.80835468
27	Abnormality of the ileum (HP:0001549)	2.76365666
28	Pancreatic cysts (HP:0001737)	2.74914903
29	Meckel diverticulum (HP:0002245)	2.74388696
30	Oral leukoplakia (HP:0002745)	2.72529675
31	Attenuation of retinal blood vessels (HP:0007843)	2.67033868
32	Ureteral duplication (HP:0000073)	2.66437917
33	Thyroid-stimulating hormone excess (HP:0002925)	2.64089224
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.64045114
35	Abnormality of T cells (HP:0002843)	2.61449539
36	Stomatitis (HP:0010280)	2.60519813
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.60438635
38	Increased hepatocellular lipid droplets (HP:0006565)	2.56264090
39	Abnormality of midbrain morphology (HP:0002418)	2.53184997
40	Molar tooth sign on MRI (HP:0002419)	2.53184997
41	3-Methylglutaconic aciduria (HP:0003535)	2.51709141
42	IgG deficiency (HP:0004315)	2.51503255
43	Pancreatic fibrosis (HP:0100732)	2.50204277
44	Abnormality of the prostate (HP:0008775)	2.49869352
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.45243466
46	Stomach cancer (HP:0012126)	2.43857086
47	Recurrent abscess formation (HP:0002722)	2.42162119
48	Ectopic kidney (HP:0000086)	2.41832125
49	Mitochondrial inheritance (HP:0001427)	2.41206938
50	True hermaphroditism (HP:0010459)	2.37991631
51	Periodontitis (HP:0000704)	2.35515782
52	Hyperglycinemia (HP:0002154)	2.34884336
53	B lymphocytopenia (HP:0010976)	2.33477092
54	Abnormality of the renal cortex (HP:0011035)	2.29645099
55	Acute necrotizing encephalopathy (HP:0006965)	2.25275099
56	Duplication of thumb phalanx (HP:0009942)	2.21235999
57	Neutropenia (HP:0001875)	2.20993005
58	Renal Fanconi syndrome (HP:0001994)	2.20905347
59	Hemiplegia (HP:0002301)	2.20860419
60	Increased CSF lactate (HP:0002490)	2.19109514
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.19010646
62	Hepatocellular necrosis (HP:0001404)	2.18433434
63	T lymphocytopenia (HP:0005403)	2.17116401
64	Decreased central vision (HP:0007663)	2.17013104
65	Increased intramyocellular lipid droplets (HP:0012240)	2.15307378
66	Abnormality of the preputium (HP:0100587)	2.12046382
67	Hepatic necrosis (HP:0002605)	2.11396813
68	Nephronophthisis (HP:0000090)	2.09833298
69	Thyroiditis (HP:0100646)	2.07218343
70	Increased muscle lipid content (HP:0009058)	2.05389449
71	Congenital sensorineural hearing impairment (HP:0008527)	2.05028645
72	Clubbing of toes (HP:0100760)	2.03798459
73	Medial flaring of the eyebrow (HP:0010747)	2.02483704
74	Severe combined immunodeficiency (HP:0004430)	2.00717290
75	Congenital stationary night blindness (HP:0007642)	1.98193250
76	Chronic bronchitis (HP:0004469)	1.96093372
77	Increased serum pyruvate (HP:0003542)	1.95881436
78	Progressive macrocephaly (HP:0004481)	1.94827821
79	Abnormality of macular pigmentation (HP:0008002)	1.94639235
80	Acute encephalopathy (HP:0006846)	1.92638413
81	Exertional dyspnea (HP:0002875)	1.92354227
82	Abnormality of T cell physiology (HP:0011840)	1.91496452
83	Pulmonary fibrosis (HP:0002206)	1.88686941
84	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.85098969
85	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.85098969
86	Increased serum lactate (HP:0002151)	1.83695806
87	Cerebellar dysplasia (HP:0007033)	1.81466753
88	Dicarboxylic aciduria (HP:0003215)	1.80193696
89	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80193696
90	Increased corneal curvature (HP:0100692)	1.79791296
91	Keratoconus (HP:0000563)	1.79791296
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79356273
93	Vitreoretinal degeneration (HP:0000655)	1.79294199
94	Optic disc pallor (HP:0000543)	1.77604686
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76956702
96	Absent radius (HP:0003974)	1.76805991
97	Elevated erythrocyte sedimentation rate (HP:0003565)	1.75574755
98	Abnormality of the renal medulla (HP:0100957)	1.73122831
99	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73098175
100	Abnormality of chromosome stability (HP:0003220)	1.72511218

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	9.15422373
2	TXK	6.61854300
3	MAP4K1	4.87115432
4	BCKDK	3.48406139
5	MAP4K2	3.29088031
6	PBK	2.08816791
7	PINK1	1.90905944
8	WNK3	1.84498611
9	FES	1.82189020
10	FRK	1.77824570
11	NUAK1	1.57812540
12	PRKCH	1.53095325
13	TLK1	1.52337875
14	GRK1	1.33244606
15	KIT	1.26022116
16	SRPK1	1.14687709
17	ADRBK2	1.09059547
18	ZAK	1.04761401
19	OBSCN	1.03917801
20	KDR	1.03515636
21	PDK2	0.97845683
22	FLT3	0.96957197
23	ZAP70	0.96719767
24	LCK	0.94289441
25	MAP2K7	0.93742457
26	MUSK	0.88831173
27	IKBKE	0.86129174
28	SYK	0.85440785
29	BMPR1B	0.84096375
30	INSRR	0.80150514
31	MAP3K4	0.76508925
32	IKBKB	0.72585111
33	VRK2	0.70775006
34	TESK2	0.70435422
35	ITK	0.70228713
36	PRKCQ	0.69382282
37	DAPK1	0.69361530
38	LYN	0.68870144
39	BMPR2	0.68253138
40	ERBB3	0.67836632
41	MAPK13	0.67773558
42	TEC	0.65980690
43	MARK3	0.65113143
44	GRK6	0.64327455
45	CSF1R	0.63301741
46	TBK1	0.61897771
47	IGF1R	0.61392779
48	MYLK	0.60006628
49	CDK3	0.59967738
50	PIK3CA	0.59528388
51	STK38L	0.56819103
52	HCK	0.56510259
53	RPS6KA5	0.56370438
54	TIE1	0.55732874
55	DYRK2	0.53611974
56	EIF2AK3	0.53432688
57	ADRBK1	0.52286719
58	BTK	0.51168859
59	CDK8	0.51023231
60	ATR	0.49693947
61	TNK2	0.48367773
62	VRK1	0.47056809
63	TRIM28	0.46446267
64	CSNK1G1	0.46105133
65	PIK3CG	0.43042344
66	CDK19	0.42519757
67	DYRK1A	0.42031917
68	MAP3K5	0.40028757
69	OXSR1	0.37608366
70	NLK	0.36844076
71	CSNK1G3	0.36631187
72	MAP2K2	0.35343979
73	JAK3	0.34801868
74	EPHA4	0.34780945
75	CSK	0.32956677
76	MATK	0.32947046
77	CSNK1A1	0.32156568
78	ATM	0.31404093
79	PRKCA	0.30238835
80	PRKCE	0.30101519
81	MAPK4	0.29688329
82	PRKACA	0.28970619
83	CSNK1A1L	0.28938594
84	CAMK2A	0.28386654
85	PHKG2	0.26436077
86	PHKG1	0.26436077
87	JAK1	0.25785890
88	PAK3	0.25361531
89	PTK2B	0.25181624
90	MAPK3	0.24652429
91	ABL1	0.24330122
92	LATS1	0.23991985
93	CSNK1G2	0.22836745
94	MAPK7	0.22757144
95	FYN	0.22605065
96	CSNK2A1	0.22033723
97	MKNK1	0.21573802
98	TYRO3	0.20468348
99	PRKCB	0.20231395
100	IRAK1	0.20143265

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	3.81159421
2	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.78411558
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.47430797
4	Asthma_Homo sapiens_hsa05310	3.47307206
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.92186514
6	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.83034041
7	RNA polymerase_Homo sapiens_hsa03020	2.78747847
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.72148554
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.57355235
10	Viral myocarditis_Homo sapiens_hsa05416	2.45704266
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.35774540
12	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.02924522
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.89608082
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87749335
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82786785
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.78848850
17	Leishmaniasis_Homo sapiens_hsa05140	1.73448349
18	Parkinsons disease_Homo sapiens_hsa05012	1.71872677
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.69092741
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66971670
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.59984673
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.53691996
23	Phototransduction_Homo sapiens_hsa04744	1.46428767
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.40641744
25	Olfactory transduction_Homo sapiens_hsa04740	1.37500164
26	Malaria_Homo sapiens_hsa05144	1.35580613
27	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.29222140
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25262265
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24741550
30	Propanoate metabolism_Homo sapiens_hsa00640	1.23082007
31	Basal transcription factors_Homo sapiens_hsa03022	1.20480832
32	Proteasome_Homo sapiens_hsa03050	1.20014305
33	Butanoate metabolism_Homo sapiens_hsa00650	1.14784965
34	Ribosome_Homo sapiens_hsa03010	1.12250429
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12021218
36	One carbon pool by folate_Homo sapiens_hsa00670	1.08631803
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.05981453
38	Purine metabolism_Homo sapiens_hsa00230	1.03783901
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01208478
40	Ether lipid metabolism_Homo sapiens_hsa00565	0.99083735
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96416974
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94955341
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94217153
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94165421
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92973827
46	RNA degradation_Homo sapiens_hsa03018	0.89463384
47	Legionellosis_Homo sapiens_hsa05134	0.87783628
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87344128
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85771214
50	Taste transduction_Homo sapiens_hsa04742	0.85214271
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83467280
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82644259
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82601740
54	Huntingtons disease_Homo sapiens_hsa05016	0.81737512
55	Pertussis_Homo sapiens_hsa05133	0.80562915
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79200438
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78837695
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76191707
59	Alzheimers disease_Homo sapiens_hsa05010	0.74132981
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73597611
61	Peroxisome_Homo sapiens_hsa04146	0.72282593
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72274735
63	Caffeine metabolism_Homo sapiens_hsa00232	0.71625039
64	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.70378838
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69919409
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.67236411
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66942738
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64164602
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61351339
70	Protein export_Homo sapiens_hsa03060	0.61102939
71	Spliceosome_Homo sapiens_hsa03040	0.60603218
72	Herpes simplex infection_Homo sapiens_hsa05168	0.59852285
73	Retinol metabolism_Homo sapiens_hsa00830	0.53597675
74	Salivary secretion_Homo sapiens_hsa04970	0.53165920
75	Fatty acid elongation_Homo sapiens_hsa00062	0.52486491
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51834380
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51388622
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47955423
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47379286
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46969110
81	Phagosome_Homo sapiens_hsa04145	0.45946744
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.45302502
83	Metabolic pathways_Homo sapiens_hsa01100	0.42587630
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41363268
85	Tuberculosis_Homo sapiens_hsa05152	0.40830606
86	ABC transporters_Homo sapiens_hsa02010	0.40300150
87	Homologous recombination_Homo sapiens_hsa03440	0.40183793
88	Complement and coagulation cascades_Homo sapiens_hsa04610	0.36974281
89	Regulation of autophagy_Homo sapiens_hsa04140	0.36666168
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.34969049
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.33541359
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32992520
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32900739
94	Mismatch repair_Homo sapiens_hsa03430	0.30614816
95	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30311745
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.25993219
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23836375
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.23693755
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22771018
100	Circadian entrainment_Homo sapiens_hsa04713	0.22686414

RPL23AP34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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