ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	5.81448866
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.72946158
3	ATP synthesis coupled proton transport (GO:0015986)	5.11538541
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.11538541
5	positive regulation of digestive system process (GO:0060456)	5.07034417
6	DNA deamination (GO:0045006)	5.06192503
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.67318862
8	respiratory electron transport chain (GO:0022904)	4.32268249
9	electron transport chain (GO:0022900)	4.26520650
10	cytidine deamination (GO:0009972)	4.24434099
11	cytidine metabolic process (GO:0046087)	4.24434099
12	cytidine catabolic process (GO:0006216)	4.24434099
13	proteasome assembly (GO:0043248)	4.21009430
14	negative regulation of heart rate (GO:0010459)	4.03971951
15	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.88415986
16	ribosomal small subunit assembly (GO:0000028)	3.85208746
17	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.77936161
18	platelet dense granule organization (GO:0060155)	3.73358503
19	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.72446512
20	respiratory chain complex IV assembly (GO:0008535)	3.52405205
21	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.48081332
22	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.46348083
23	protein complex biogenesis (GO:0070271)	3.43746924
24	actin nucleation (GO:0045010)	3.42042151
25	positive regulation of mast cell degranulation (GO:0043306)	3.40782572
26	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.40782572
27	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.39787446
28	hydrogen ion transmembrane transport (GO:1902600)	3.39319588
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.36035459
30	GPI anchor metabolic process (GO:0006505)	3.23070044
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.21239289
32	proton transport (GO:0015992)	3.20775624
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.19864399
34	detection of light stimulus involved in visual perception (GO:0050908)	3.19864399
35	GPI anchor biosynthetic process (GO:0006506)	3.18773674
36	cytochrome complex assembly (GO:0017004)	3.18006408
37	hydrogen transport (GO:0006818)	3.17956143
38	adaptation of signaling pathway (GO:0023058)	3.14809512
39	ATP biosynthetic process (GO:0006754)	3.13747702
40	regulation of interleukin-8 secretion (GO:2000482)	3.07808909
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07042181
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03756119
43	S-adenosylmethionine metabolic process (GO:0046500)	3.03409703
44	mannosylation (GO:0097502)	3.01121490
45	positive regulation of mast cell activation (GO:0033005)	3.00845932
46	regulation of germinal center formation (GO:0002634)	3.00034098
47	indolalkylamine metabolic process (GO:0006586)	2.96681453
48	dopamine transport (GO:0015872)	2.96126070
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.94763506
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.94763506
51	NADH dehydrogenase complex assembly (GO:0010257)	2.94763506
52	negative regulation of mast cell activation (GO:0033004)	2.93059403
53	regulation of hypersensitivity (GO:0002883)	2.85291805
54	protein-cofactor linkage (GO:0018065)	2.80554442
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80124296
56	regulation of cellular respiration (GO:0043457)	2.79346759
57	antigen processing and presentation via MHC class Ib (GO:0002475)	2.77414381
58	indole-containing compound catabolic process (GO:0042436)	2.77001149
59	indolalkylamine catabolic process (GO:0046218)	2.77001149
60	tryptophan catabolic process (GO:0006569)	2.77001149
61	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.76592633
62	kynurenine metabolic process (GO:0070189)	2.74927532
63	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.72079057
64	mast cell activation (GO:0045576)	2.71149423
65	regulation of cellular amino acid metabolic process (GO:0006521)	2.70109050
66	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.70047456
67	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.69401673
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.65655325
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65643593
70	tryptophan metabolic process (GO:0006568)	2.61640239
71	prenylation (GO:0097354)	2.61264065
72	protein prenylation (GO:0018342)	2.61264065
73	behavioral response to nicotine (GO:0035095)	2.61241207
74	regulation of T cell tolerance induction (GO:0002664)	2.60678303
75	purine nucleotide salvage (GO:0032261)	2.59860804
76	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.59242408
77	multicellular organism reproduction (GO:0032504)	2.57747847
78	regulation of B cell receptor signaling pathway (GO:0050855)	2.57645047
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51701478
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51701478
81	left/right axis specification (GO:0070986)	2.50264008
82	gonadal mesoderm development (GO:0007506)	2.49918518
83	negative regulation by host of viral transcription (GO:0043922)	2.48618497
84	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.48046684
85	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.47491288
86	protein neddylation (GO:0045116)	2.45103444
87	positive thymic T cell selection (GO:0045059)	2.44863549
88	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.44492114
89	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.42267626
90	response to interferon-beta (GO:0035456)	2.41438818
91	rRNA catabolic process (GO:0016075)	2.40849187
92	positive regulation of protein homodimerization activity (GO:0090073)	2.39641276
93	aggressive behavior (GO:0002118)	2.39112751
94	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.36494448
95	positive regulation of vesicle fusion (GO:0031340)	2.35167620
96	T cell costimulation (GO:0031295)	2.35081736
97	regulation of tolerance induction (GO:0002643)	2.35044132
98	aldehyde catabolic process (GO:0046185)	2.35016169
99	positive regulation of interleukin-8 secretion (GO:2000484)	2.34794351
100	positive regulation of tolerance induction (GO:0002645)	2.34226483

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.88324756
2	VDR_22108803_ChIP-Seq_LS180_Human	3.43600547
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.93446678
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.86226186
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.82020150
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64840674
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56175237
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.51735464
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44656307
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.35084653
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.29523575
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.18687775
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.10346242
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07988245
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.96485688
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94441425
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.92886876
18	FUS_26573619_Chip-Seq_HEK293_Human	1.91476472
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90444170
20	P300_19829295_ChIP-Seq_ESCs_Human	1.87255061
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80641056
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79937545
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.79657920
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.77817017
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.77507660
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.67905783
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.66218784
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65474205
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.63545053
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62060664
31	EWS_26573619_Chip-Seq_HEK293_Human	1.60790231
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54314915
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54314915
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.53734434
35	AR_20517297_ChIP-Seq_VCAP_Human	1.51654263
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49982248
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49537125
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49537125
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.49477326
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.48522635
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47883424
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47749454
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.47749454
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47564783
45	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.45976627
46	GATA3_26560356_Chip-Seq_TH2_Human	1.45131372
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.44602936
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38485353
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35416994
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.33820729
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.33803074
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33769917
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.30678731
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29976066
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28875930
56	MYB_26560356_Chip-Seq_TH2_Human	1.26326544
57	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26300408
58	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.26112458
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22688583
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.22133767
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21744457
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21426560
63	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.21326046
64	NCOR_22424771_ChIP-Seq_293T_Human	1.20726673
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.20592890
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.20003674
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17880919
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15245944
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13825982
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13703525
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.13071416
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12449746
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12286345
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12026057
75	AR_25329375_ChIP-Seq_VCAP_Human	1.11521327
76	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10895775
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10616732
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10584999
79	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10330964
80	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08880410
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08692431
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08222495
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07728738
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06765593
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05950015
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05933936
87	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04669800
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04617105
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03556828
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03126619
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02980673
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02652976
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02627970
94	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02531570
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02154356
96	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01586265
97	GATA3_26560356_Chip-Seq_TH1_Human	1.01046532
98	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00637251
99	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99569282
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98265971

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.88072752
2	MP0009379_abnormal_foot_pigmentation	3.65637094
3	MP0005671_abnormal_response_to	3.63565383
4	MP0002837_dystrophic_cardiac_calcinosis	3.07130824
5	MP0003195_calcinosis	2.90878881
6	MP0000372_irregular_coat_pigmentation	2.67720423
7	MP0003646_muscle_fatigue	2.65003723
8	MP0003806_abnormal_nucleotide_metabolis	2.62750563
9	MP0010386_abnormal_urinary_bladder	2.53641058
10	MP0004147_increased_porphyrin_level	2.52258699
11	MP0006072_abnormal_retinal_apoptosis	2.43089734
12	MP0005551_abnormal_eye_electrophysiolog	2.15459698
13	MP0009785_altered_susceptibility_to	2.07170478
14	MP0008872_abnormal_physiological_respon	2.03939003
15	MP0005075_abnormal_melanosome_morpholog	2.03451405
16	MP0005253_abnormal_eye_physiology	1.88960622
17	MP0002166_altered_tumor_susceptibility	1.85261738
18	MP0005645_abnormal_hypothalamus_physiol	1.84839354
19	MP0005646_abnormal_pituitary_gland	1.77719803
20	MP0001968_abnormal_touch/_nociception	1.76652101
21	MP0002736_abnormal_nociception_after	1.65919569
22	MP0003252_abnormal_bile_duct	1.57672581
23	MP0001800_abnormal_humoral_immune	1.56158800
24	MP0001905_abnormal_dopamine_level	1.54219344
25	MP0001873_stomach_inflammation	1.49370775
26	MP0002102_abnormal_ear_morphology	1.44861680
27	MP0001986_abnormal_taste_sensitivity	1.43595020
28	MP0003880_abnormal_central_pattern	1.40584597
29	MP0002006_tumorigenesis	1.36543148
30	MP0009333_abnormal_splenocyte_physiolog	1.34726090
31	MP0005000_abnormal_immune_tolerance	1.33892700
32	MP0003763_abnormal_thymus_physiology	1.33302251
33	MP0002735_abnormal_chemical_nociception	1.32578895
34	MP0008875_abnormal_xenobiotic_pharmacok	1.30331636
35	MP0005367_renal/urinary_system_phenotyp	1.29590052
36	MP0000516_abnormal_urinary_system	1.29590052
37	MP0005410_abnormal_fertilization	1.28868344
38	MP0002163_abnormal_gland_morphology	1.28747162
39	MP0006276_abnormal_autonomic_nervous	1.27758867
40	MP0009764_decreased_sensitivity_to	1.27196782
41	MP0008877_abnormal_DNA_methylation	1.26010444
42	MP0002723_abnormal_immune_serum	1.25000011
43	MP0005636_abnormal_mineral_homeostasis	1.23603314
44	MP0001764_abnormal_homeostasis	1.23367042
45	MP0002876_abnormal_thyroid_physiology	1.22963045
46	MP0002095_abnormal_skin_pigmentation	1.16926759
47	MP0001919_abnormal_reproductive_system	1.15177177
48	MP0000685_abnormal_immune_system	1.14105886
49	MP0002420_abnormal_adaptive_immunity	1.13332855
50	MP0005379_endocrine/exocrine_gland_phen	1.12339031
51	MP0002452_abnormal_antigen_presenting	1.11484829
52	MP0001819_abnormal_immune_cell	1.10752908
53	MP0001970_abnormal_pain_threshold	1.10610678
54	MP0003137_abnormal_impulse_conducting	1.09937815
55	MP0004885_abnormal_endolymph	1.09734900
56	MP0002148_abnormal_hypersensitivity_rea	1.09541413
57	MP0004142_abnormal_muscle_tone	1.08136585
58	MP0009745_abnormal_behavioral_response	1.04124293
59	MP0006036_abnormal_mitochondrial_physio	1.03427946
60	MP0001501_abnormal_sleep_pattern	1.03282603
61	MP0002638_abnormal_pupillary_reflex	1.02454352
62	MP0005389_reproductive_system_phenotype	1.02118160
63	MP0006082_CNS_inflammation	1.01357609
64	MP0009697_abnormal_copulation	1.01031993
65	MP0008995_early_reproductive_senescence	1.00787856
66	MP0005171_absent_coat_pigmentation	1.00464911
67	MP0003866_abnormal_defecation	0.99895071
68	MP0004145_abnormal_muscle_electrophysio	0.99890850
69	MP0005085_abnormal_gallbladder_physiolo	0.99746814
70	MP0001765_abnormal_ion_homeostasis	0.96022883
71	MP0002138_abnormal_hepatobiliary_system	0.93690805
72	MP0005387_immune_system_phenotype	0.93274743
73	MP0001790_abnormal_immune_system	0.93274743
74	MP0002272_abnormal_nervous_system	0.92338198
75	MP0006054_spinal_hemorrhage	0.91317101
76	MP0002933_joint_inflammation	0.90178945
77	MP0003724_increased_susceptibility_to	0.89614058
78	MP0002234_abnormal_pharynx_morphology	0.89081049
79	MP0001529_abnormal_vocalization	0.87169515
80	MP0005025_abnormal_response_to	0.86671694
81	MP0002693_abnormal_pancreas_physiology	0.86213564
82	MP0001486_abnormal_startle_reflex	0.85056431
83	MP0001756_abnormal_urination	0.84052457
84	MP0003136_yellow_coat_color	0.83663046
85	MP0003878_abnormal_ear_physiology	0.82896480
86	MP0005377_hearing/vestibular/ear_phenot	0.82896480
87	MP0001963_abnormal_hearing_physiology	0.81834684
88	MP0001845_abnormal_inflammatory_respons	0.81534895
89	MP0000716_abnormal_immune_system	0.81311019
90	MP0009046_muscle_twitch	0.81287001
91	MP0010155_abnormal_intestine_physiology	0.81141754
92	MP0003283_abnormal_digestive_organ	0.81036537
93	MP0005084_abnormal_gallbladder_morpholo	0.80916110
94	MP0000639_abnormal_adrenal_gland	0.80783133
95	MP0005332_abnormal_amino_acid	0.80202943
96	MP0004019_abnormal_vitamin_homeostasis	0.79044798
97	MP0001485_abnormal_pinna_reflex	0.77259756
98	MP0004133_heterotaxia	0.76973824
99	MP0005083_abnormal_biliary_tract	0.75835256
100	MP0002090_abnormal_vision	0.75303609

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.42002404
2	Acute necrotizing encephalopathy (HP:0006965)	4.19147840
3	Hepatocellular necrosis (HP:0001404)	4.07299425
4	Increased CSF lactate (HP:0002490)	3.97221691
5	Hypoproteinemia (HP:0003075)	3.65404649
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.64342058
7	Pancreatic cysts (HP:0001737)	3.62769310
8	Increased hepatocellular lipid droplets (HP:0006565)	3.60668508
9	IgG deficiency (HP:0004315)	3.57739839
10	Progressive macrocephaly (HP:0004481)	3.57547438
11	Decreased central vision (HP:0007663)	3.56318827
12	Hepatic necrosis (HP:0002605)	3.55201362
13	Acute encephalopathy (HP:0006846)	3.47005755
14	Lipid accumulation in hepatocytes (HP:0006561)	3.36493179
15	True hermaphroditism (HP:0010459)	3.30202969
16	Congenital stationary night blindness (HP:0007642)	3.24311960
17	Hypothermia (HP:0002045)	3.21380409
18	Congenital, generalized hypertrichosis (HP:0004540)	3.20813572
19	Pancreatic fibrosis (HP:0100732)	3.12103238
20	Renal Fanconi syndrome (HP:0001994)	3.09211507
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.94693535
22	Attenuation of retinal blood vessels (HP:0007843)	2.92561495
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90897755
24	Abnormality of macular pigmentation (HP:0008002)	2.87691048
25	Cerebral edema (HP:0002181)	2.80347390
26	Abolished electroretinogram (ERG) (HP:0000550)	2.79210201
27	B lymphocytopenia (HP:0010976)	2.71539357
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70990749
29	3-Methylglutaconic aciduria (HP:0003535)	2.68438360
30	Molar tooth sign on MRI (HP:0002419)	2.57014899
31	Abnormality of midbrain morphology (HP:0002418)	2.57014899
32	Increased intramyocellular lipid droplets (HP:0012240)	2.53231134
33	Optic disc pallor (HP:0000543)	2.52453980
34	Abnormality of B cell number (HP:0010975)	2.49610203
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.48920135
36	Exertional dyspnea (HP:0002875)	2.48363224
37	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.47685629
38	Constricted visual fields (HP:0001133)	2.37208421
39	Increased serum lactate (HP:0002151)	2.36674696
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.35734115
41	Severe combined immunodeficiency (HP:0004430)	2.28960850
42	Chronic diarrhea (HP:0002028)	2.23825729
43	Lactic acidosis (HP:0003128)	2.23612521
44	Aplastic anemia (HP:0001915)	2.23457629
45	Abnormality of the prostate (HP:0008775)	2.23060536
46	Respiratory failure (HP:0002878)	2.22869734
47	Stomatitis (HP:0010280)	2.22198659
48	Adactyly (HP:0009776)	2.19983576
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.19067150
50	Abnormality of renal resorption (HP:0011038)	2.17981712
51	Abnormality of urine glucose concentration (HP:0011016)	2.17578841
52	Glycosuria (HP:0003076)	2.17578841
53	Type 2 muscle fiber atrophy (HP:0003554)	2.17446393
54	Type I transferrin isoform profile (HP:0003642)	2.15549457
55	Cystic liver disease (HP:0006706)	2.12856767
56	Increased muscle lipid content (HP:0009058)	2.07565078
57	Abnormality of alanine metabolism (HP:0010916)	2.07241633
58	Hyperalaninemia (HP:0003348)	2.07241633
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07241633
60	Thyroiditis (HP:0100646)	2.04866427
61	Methylmalonic acidemia (HP:0002912)	2.04841495
62	Recurrent bronchitis (HP:0002837)	2.03824095
63	Parakeratosis (HP:0001036)	2.02523845
64	Male pseudohermaphroditism (HP:0000037)	2.00403673
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99796935
66	Absent/shortened dynein arms (HP:0200106)	1.99796935
67	Medial flaring of the eyebrow (HP:0010747)	1.98112106
68	Sclerocornea (HP:0000647)	1.96584269
69	Rectovaginal fistula (HP:0000143)	1.95983224
70	Rectal fistula (HP:0100590)	1.95983224
71	Macular degeneration (HP:0000608)	1.93834079
72	Alveolar cell carcinoma (HP:0006519)	1.93415259
73	Bronchitis (HP:0012387)	1.91004019
74	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90441434
75	Nephronophthisis (HP:0000090)	1.88107868
76	Lethargy (HP:0001254)	1.87165510
77	T lymphocytopenia (HP:0005403)	1.86502301
78	Leukodystrophy (HP:0002415)	1.85273340
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84772189
80	Chronic sinusitis (HP:0011109)	1.83301767
81	Neoplasm of the tracheobronchial system (HP:0100552)	1.82614858
82	Hypoalbuminemia (HP:0003073)	1.82409064
83	Abnormal albumin level (HP:0012116)	1.82409064
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79960345
85	Panhypogammaglobulinemia (HP:0003139)	1.79942710
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78308222
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78308222
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78283998
89	Hyperphosphaturia (HP:0003109)	1.77707358
90	Cerebral palsy (HP:0100021)	1.75934352
91	Congenital primary aphakia (HP:0007707)	1.73418305
92	Congenital hepatic fibrosis (HP:0002612)	1.72996278
93	Chronic bronchitis (HP:0004469)	1.72356635
94	Abnormality of T cell number (HP:0011839)	1.71355310
95	Recurrent cutaneous fungal infections (HP:0011370)	1.71344435
96	Chronic mucocutaneous candidiasis (HP:0002728)	1.71344435
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.68472575
98	Abnormality of T cells (HP:0002843)	1.67872710
99	Short tibia (HP:0005736)	1.66651686
100	Abnormal glycosylation (HP:0012345)	1.65752756

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	4.09112252
2	BMPR2	3.30022553
3	MAP4K2	3.19106680
4	KDR	2.91369353
5	FRK	2.88939137
6	TXK	2.83882955
7	CDK19	2.46707854
8	TAOK3	2.39992287
9	ERBB3	2.39526470
10	ZAK	2.26223773
11	SCYL2	2.25150961
12	GRK1	2.21471532
13	MYLK	2.19240494
14	BCKDK	2.16853844
15	TLK1	2.13103367
16	TEC	1.80196478
17	ADRBK2	1.61204827
18	PINK1	1.52773165
19	TRPM7	1.46327500
20	KIT	1.42531856
21	ITK	1.41026144
22	MUSK	1.33182021
23	BMPR1B	1.29992782
24	MAP4K1	1.29368443
25	EIF2AK3	1.24985465
26	INSRR	1.24731126
27	NUAK1	1.23435043
28	CSF1R	1.22339114
29	MAP2K7	1.22020337
30	GRK6	1.19092938
31	SYK	1.15335496
32	BTK	1.13761132
33	WNK3	1.07192940
34	LYN	1.06370698
35	TESK2	1.02395724
36	OXSR1	1.00955904
37	TNK2	0.99217611
38	IKBKB	0.98576281
39	MAPK13	0.96372234
40	PRKCE	0.93877276
41	TIE1	0.93207851
42	FLT3	0.91518992
43	STK38L	0.90957272
44	PIK3CG	0.89273684
45	OBSCN	0.89053264
46	MAP3K4	0.85786429
47	PLK4	0.84087376
48	CSNK1G3	0.83939312
49	CSNK1A1L	0.83837552
50	PASK	0.83510593
51	BUB1	0.83186605
52	VRK1	0.82634964
53	VRK2	0.82542085
54	CSNK1G2	0.81226007
55	MST4	0.80721896
56	MAP2K6	0.79886959
57	ROCK1	0.79202043
58	DAPK1	0.76640504
59	RPS6KA4	0.75914850
60	LCK	0.74476119
61	NEK6	0.74002545
62	DAPK3	0.73200420
63	ILK	0.72857170
64	LIMK1	0.71502326
65	TESK1	0.69461416
66	PHKG1	0.66542330
67	PHKG2	0.66542330
68	PRKCQ	0.65308822
69	ABL1	0.64614231
70	WNK4	0.64255614
71	FES	0.64080275
72	CSNK1G1	0.63283632
73	CDK8	0.62713902
74	IGF1R	0.59978037
75	PTK2B	0.58983193
76	STK39	0.58573599
77	MATK	0.58428676
78	PBK	0.57316614
79	PRKACA	0.54984675
80	NME1	0.54330233
81	LATS1	0.50034836
82	PRKCA	0.49363618
83	PKN1	0.47100685
84	MARK3	0.45245637
85	STK16	0.43860230
86	PLK2	0.43793634
87	EGFR	0.42135105
88	PIM1	0.41386513
89	ERBB4	0.41174939
90	CAMK2A	0.38739738
91	ADRBK1	0.37335301
92	DAPK2	0.34946344
93	PRKACG	0.34083365
94	CSNK1A1	0.33706776
95	PRKG1	0.33542370
96	RPS6KA5	0.32463246
97	CDK3	0.30744011
98	HCK	0.30612472
99	CSNK2A1	0.30583065
100	GRK7	0.30093556

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.90765203
2	Asthma_Homo sapiens_hsa05310	3.90633545
3	Proteasome_Homo sapiens_hsa03050	3.17408397
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.10867317
5	Parkinsons disease_Homo sapiens_hsa05012	3.06190988
6	Allograft rejection_Homo sapiens_hsa05330	2.98899906
7	Protein export_Homo sapiens_hsa03060	2.97948826
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.96062350
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.95928511
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.72208181
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.65428922
12	Ribosome_Homo sapiens_hsa03010	2.40842536
13	Alzheimers disease_Homo sapiens_hsa05010	2.14512472
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.12874089
15	Phototransduction_Homo sapiens_hsa04744	1.95481008
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94146257
17	Huntingtons disease_Homo sapiens_hsa05016	1.93360021
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81548966
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78984751
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.67477811
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.67401294
22	RNA degradation_Homo sapiens_hsa03018	1.49211895
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45106338
24	Viral myocarditis_Homo sapiens_hsa05416	1.44503982
25	RNA polymerase_Homo sapiens_hsa03020	1.32819780
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28552524
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.26876531
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.25763099
29	Caffeine metabolism_Homo sapiens_hsa00232	1.23766335
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22727708
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15849607
32	Nicotine addiction_Homo sapiens_hsa05033	1.15736302
33	One carbon pool by folate_Homo sapiens_hsa00670	1.08538342
34	Homologous recombination_Homo sapiens_hsa03440	1.05865254
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03084450
36	Olfactory transduction_Homo sapiens_hsa04740	1.00120653
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98777940
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96574127
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94338853
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.93214572
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89717019
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89113118
43	Butanoate metabolism_Homo sapiens_hsa00650	0.84683117
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80311970
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75801464
46	Taste transduction_Homo sapiens_hsa04742	0.74866735
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.74077298
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73843470
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73042006
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70432617
51	Morphine addiction_Homo sapiens_hsa05032	0.68382604
52	Retinol metabolism_Homo sapiens_hsa00830	0.67849812
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67466876
54	Peroxisome_Homo sapiens_hsa04146	0.66772683
55	Regulation of autophagy_Homo sapiens_hsa04140	0.66586062
56	Sulfur metabolism_Homo sapiens_hsa00920	0.65728795
57	Propanoate metabolism_Homo sapiens_hsa00640	0.64881013
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.64698330
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63048355
60	Leishmaniasis_Homo sapiens_hsa05140	0.62022333
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61708927
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60382166
63	ABC transporters_Homo sapiens_hsa02010	0.59594284
64	Basal transcription factors_Homo sapiens_hsa03022	0.56085659
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56053563
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55003783
67	Purine metabolism_Homo sapiens_hsa00230	0.54651992
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.53921032
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53045274
70	GABAergic synapse_Homo sapiens_hsa04727	0.50686985
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48770799
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47357134
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46051244
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45722701
75	Metabolic pathways_Homo sapiens_hsa01100	0.44217944
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42918622
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39139691
78	Salivary secretion_Homo sapiens_hsa04970	0.39060737
79	Glutathione metabolism_Homo sapiens_hsa00480	0.36855313
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36565948
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.36077326
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35407886
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.34879525
84	Serotonergic synapse_Homo sapiens_hsa04726	0.34185414
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32401997
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31275680
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31132905
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31076495
89	Phagosome_Homo sapiens_hsa04145	0.29251188
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28771604
91	RNA transport_Homo sapiens_hsa03013	0.27106115
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.26329231
93	Legionellosis_Homo sapiens_hsa05134	0.26106141
94	Herpes simplex infection_Homo sapiens_hsa05168	0.25455257
95	Tuberculosis_Homo sapiens_hsa05152	0.25187387
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.24597257
97	Salmonella infection_Homo sapiens_hsa05132	0.23743310
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22170886
99	Pertussis_Homo sapiens_hsa05133	0.17026110
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.14902967

RPL23AP35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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