ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurotransmitter-gated ion channel clustering (GO:0072578)	7.62661266
2	activated T cell proliferation (GO:0050798)	6.46457730
3	pyrimidine dimer repair (GO:0006290)	6.40867698
4	ER overload response (GO:0006983)	6.19819272
5	sexual reproduction (GO:0019953)	5.47046985
6	nonmotile primary cilium assembly (GO:0035058)	5.19023086
7	regulation of non-canonical Wnt signaling pathway (GO:2000050)	4.72667078
8	COPII vesicle coating (GO:0048208)	4.51193992
9	kidney morphogenesis (GO:0060993)	4.47977476
10	anatomical structure regression (GO:0060033)	4.41481305
11	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	4.34021313
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.25669389
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.25669389
14	sex differentiation (GO:0007548)	3.93367363
15	glycerophospholipid catabolic process (GO:0046475)	3.93360653
16	adaptation of signaling pathway (GO:0023058)	3.78876506
17	positive regulation of developmental pigmentation (GO:0048087)	3.76376458
18	positive regulation of male gonad development (GO:2000020)	3.73924280
19	mitotic G1 DNA damage checkpoint (GO:0031571)	3.72902820
20	protein-chromophore linkage (GO:0018298)	3.71759909
21	fructose metabolic process (GO:0006000)	3.66853044
22	lipid particle organization (GO:0034389)	3.64815708
23	left/right pattern formation (GO:0060972)	3.64777335
24	glycosylceramide metabolic process (GO:0006677)	3.63183677
25	heme transport (GO:0015886)	3.58750248
26	negative regulation of histone acetylation (GO:0035067)	3.55203731
27	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.48421938
28	G1 DNA damage checkpoint (GO:0044783)	3.46182330
29	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.44432121
30	specification of organ identity (GO:0010092)	3.37774474
31	limb bud formation (GO:0060174)	3.32644103
32	spermatid nucleus differentiation (GO:0007289)	3.28432465
33	regulation of cilium movement (GO:0003352)	3.27670283
34	regulation of pigment cell differentiation (GO:0050932)	3.27616588
35	mitotic G1/S transition checkpoint (GO:0044819)	3.25752019
36	intestinal cholesterol absorption (GO:0030299)	3.24651932
37	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.21639506
38	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.21639506
39	parturition (GO:0007567)	3.20732310
40	secondary heart field specification (GO:0003139)	3.20450165
41	heart field specification (GO:0003128)	3.20450165
42	aldehyde catabolic process (GO:0046185)	3.18468916
43	regulation of glucocorticoid secretion (GO:2000849)	3.10669289
44	early endosome to late endosome transport (GO:0045022)	3.10069782
45	short-chain fatty acid metabolic process (GO:0046459)	3.08094398
46	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.07182643
47	sialylation (GO:0097503)	3.07083532
48	pancreas development (GO:0031016)	3.05040618
49	appendage development (GO:0048736)	3.02214041
50	limb development (GO:0060173)	3.02214041
51	glucose 6-phosphate metabolic process (GO:0051156)	3.02115372
52	keratinocyte development (GO:0003334)	2.98115033
53	neurofilament cytoskeleton organization (GO:0060052)	2.97182593
54	Sertoli cell development (GO:0060009)	2.94887526
55	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.93056621
56	regulation of collateral sprouting (GO:0048670)	2.92591645
57	gluconeogenesis (GO:0006094)	2.92309187
58	regulation of keratinocyte proliferation (GO:0010837)	2.91281304
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.90181744
60	regulation of cholesterol homeostasis (GO:2000188)	2.89756464
61	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.88687803
62	maintenance of protein location in nucleus (GO:0051457)	2.88667825
63	response to nitrosative stress (GO:0051409)	2.88209396
64	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.87150809
65	lung secretory cell differentiation (GO:0061140)	2.85859732
66	neurotransmitter catabolic process (GO:0042135)	2.85482683
67	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.83552365
68	glycolytic process (GO:0006096)	2.82442916
69	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.81611225
70	positive regulation of mitochondrial fission (GO:0090141)	2.81263631
71	negative regulation of digestive system process (GO:0060457)	2.81003047
72	NADP metabolic process (GO:0006739)	2.79260364
73	regulation of male gonad development (GO:2000018)	2.78714416
74	negative regulation of circadian rhythm (GO:0042754)	2.78506627
75	positive regulation of guanylate cyclase activity (GO:0031284)	2.76939553
76	platelet dense granule organization (GO:0060155)	2.76915981
77	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)	2.73595836
78	positive regulation of fatty acid oxidation (GO:0046321)	2.73498467
79	cerebral cortex radially oriented cell migration (GO:0021799)	2.70879981
80	negative regulation of dendrite development (GO:2000171)	2.70506204
81	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.70062525
82	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.68895710
83	hexose biosynthetic process (GO:0019319)	2.68173084
84	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.64683847
85	regulation of meiosis I (GO:0060631)	2.64292958
86	dentate gyrus development (GO:0021542)	2.63925624
87	binding of sperm to zona pellucida (GO:0007339)	2.62284634
88	protein K11-linked deubiquitination (GO:0035871)	2.61457678
89	chondrocyte development (GO:0002063)	2.59120442
90	postsynaptic membrane organization (GO:0001941)	2.58853382
91	startle response (GO:0001964)	2.58789606
92	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.58568240
93	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.56875329
94	cellular response to cholesterol (GO:0071397)	2.56636635
95	gonadal mesoderm development (GO:0007506)	2.54903341
96	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.53813810
97	vascular smooth muscle contraction (GO:0014829)	2.50238797
98	positive regulation of nuclease activity (GO:0032075)	2.48997121
99	tyrosine phosphorylation of STAT protein (GO:0007260)	11.7359803
100	acrosome assembly (GO:0001675)	10.7994931

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.24143749
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.00490484
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.96179067
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.73644633
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.57029068
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.48122265
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.22991898
8	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.12550988
9	VDR_22108803_ChIP-Seq_LS180_Human	3.07224916
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.86622496
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.86250049
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.77266337
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.75150187
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.73435410
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.71007310
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.14710635
17	EWS_26573619_Chip-Seq_HEK293_Human	2.07223712
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02043147
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.99957448
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.93034393
21	P300_19829295_ChIP-Seq_ESCs_Human	1.92142550
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.87557743
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.86411191
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85695028
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81871002
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79357934
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77608388
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.76510929
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.76054155
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69642708
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67304320
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66971522
33	TCF4_22108803_ChIP-Seq_LS180_Human	1.64819140
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60576636
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54414092
36	AR_25329375_ChIP-Seq_VCAP_Human	1.54313143
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49904371
38	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.49641806
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.48558445
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48137818
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47957390
42	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.46510644
43	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.44419139
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43987003
45	CDX2_22108803_ChIP-Seq_LS180_Human	1.36136592
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.36111673
47	GATA1_22025678_ChIP-Seq_K562_Human	1.35686151
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34503917
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33442789
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31726781
51	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.27238331
52	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.27238331
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26779305
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22603779
55	TP53_16413492_ChIP-PET_HCT116_Human	1.22034465
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19439605
57	RXR_22108803_ChIP-Seq_LS180_Human	1.18420514
58	TCF4_23295773_ChIP-Seq_U87_Human	1.18192806
59	FUS_26573619_Chip-Seq_HEK293_Human	1.17857393
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17128613
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16871410
62	TP53_18474530_ChIP-ChIP_U2OS_Human	1.16224096
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15958340
64	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.15506138
65	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13017563
66	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11956187
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11755578
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.11755578
69	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08653012
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08410819
71	STAT3_23295773_ChIP-Seq_U87_Human	1.07588602
72	NCOR_22424771_ChIP-Seq_293T_Human	1.06220370
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04268907
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03362878
75	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.99847539
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98640747
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97429490
78	BCAT_22108803_ChIP-Seq_LS180_Human	0.95963705
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.95718361
80	KDM2B_26808549_Chip-Seq_REH_Human	0.93898134
81	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.92985145
82	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92346609
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.90970757
84	VDR_23849224_ChIP-Seq_CD4+_Human	0.90966555
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90456265
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89708449
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.89286768
88	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.88300620
89	AR_20517297_ChIP-Seq_VCAP_Human	0.87950076
90	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.87452566
91	EOMES_21245162_ChIP-Seq_HESCs_Human	0.86919051
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86481864
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.85008797
94	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.84973338
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.84909396
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.84212786
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.81614790
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.79760642
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.79207502
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.79158997

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.90609686
2	MP0008877_abnormal_DNA_methylation	4.65953870
3	MP0008995_early_reproductive_senescence	4.12013728
4	MP0002736_abnormal_nociception_after	3.03437736
5	MP0002638_abnormal_pupillary_reflex	3.01519076
6	MP0001968_abnormal_touch/_nociception	2.84120005
7	MP0000516_abnormal_urinary_system	2.72822172
8	MP0005367_renal/urinary_system_phenotyp	2.72822172
9	MP0003786_premature_aging	2.58652153
10	MP0009053_abnormal_anal_canal	2.56549740
11	MP0003806_abnormal_nucleotide_metabolis	2.53070230
12	MP0009780_abnormal_chondrocyte_physiolo	2.33329769
13	MP0006292_abnormal_olfactory_placode	2.21159671
14	MP0003868_abnormal_feces_composition	2.20600118
15	MP0008007_abnormal_cellular_replicative	2.07704934
16	MP0001666_abnormal_nutrient_absorption	2.06002991
17	MP0003119_abnormal_digestive_system	2.05838608
18	MP0002098_abnormal_vibrissa_morphology	2.03583755
19	MP0004133_heterotaxia	1.97407994
20	MP0002938_white_spotting	1.84092446
21	MP0000678_abnormal_parathyroid_gland	1.82218721
22	MP0000569_abnormal_digit_pigmentation	1.81419343
23	MP0003385_abnormal_body_wall	1.75996221
24	MP0005220_abnormal_exocrine_pancreas	1.73367328
25	MP0003567_abnormal_fetal_cardiomyocyte	1.72031266
26	MP0006276_abnormal_autonomic_nervous	1.70551927
27	MP0004885_abnormal_endolymph	1.70266629
28	MP0005085_abnormal_gallbladder_physiolo	1.57489590
29	MP0002751_abnormal_autonomic_nervous	1.50263417
30	MP0003942_abnormal_urinary_system	1.43331687
31	MP0001486_abnormal_startle_reflex	1.41114935
32	MP0003122_maternal_imprinting	1.40848031
33	MP0000534_abnormal_ureter_morphology	1.32289922
34	MP0000537_abnormal_urethra_morphology	1.28149833
35	MP0005187_abnormal_penis_morphology	1.26948710
36	MP0003121_genomic_imprinting	1.24129247
37	MP0005360_urolithiasis	1.23593071
38	MP0003880_abnormal_central_pattern	1.23275432
39	MP0003937_abnormal_limbs/digits/tail_de	1.23035051
40	MP0004134_abnormal_chest_morphology	1.22396646
41	MP0000778_abnormal_nervous_system	1.21255849
42	MP0001529_abnormal_vocalization	1.20949375
43	MP0008789_abnormal_olfactory_epithelium	1.20218822
44	MP0005365_abnormal_bile_salt	1.19771711
45	MP0001727_abnormal_embryo_implantation	1.18357985
46	MP0000013_abnormal_adipose_tissue	1.17652916
47	MP0005551_abnormal_eye_electrophysiolog	1.15991269
48	MP0009250_abnormal_appendicular_skeleto	1.14435408
49	MP0002653_abnormal_ependyma_morphology	1.13031661
50	MP0001340_abnormal_eyelid_morphology	1.08316874
51	MP0004043_abnormal_pH_regulation	1.03125297
52	MP0000465_gastrointestinal_hemorrhage	1.02971777
53	MP0004215_abnormal_myocardial_fiber	1.00208615
54	MP0001502_abnormal_circadian_rhythm	0.99912316
55	MP0000653_abnormal_sex_gland	0.97150942
56	MP0008932_abnormal_embryonic_tissue	0.94752903
57	MP0008873_increased_physiological_sensi	0.94469577
58	MP0003787_abnormal_imprinting	0.92706399
59	MP0000538_abnormal_urinary_bladder	0.92706082
60	MP0000639_abnormal_adrenal_gland	0.92218772
61	MP0005499_abnormal_olfactory_system	0.91890405
62	MP0005394_taste/olfaction_phenotype	0.91890405
63	MP0002233_abnormal_nose_morphology	0.91886613
64	MP0001929_abnormal_gametogenesis	0.90296626
65	MP0003950_abnormal_plasma_membrane	0.88882491
66	MP0001119_abnormal_female_reproductive	0.86961170
67	MP0004142_abnormal_muscle_tone	0.86881992
68	MP0002160_abnormal_reproductive_system	0.84900619
69	MP0002557_abnormal_social/conspecific_i	0.84496828
70	MP0001177_atelectasis	0.83539221
71	MP0000647_abnormal_sebaceous_gland	0.82697261
72	MP0000462_abnormal_digestive_system	0.81080982
73	MP0001145_abnormal_male_reproductive	0.80534940
74	MP0002909_abnormal_adrenal_gland	0.77330452
75	MP0005647_abnormal_sex_gland	0.77105332
76	MP0003698_abnormal_male_reproductive	0.76967775
77	MP0003634_abnormal_glial_cell	0.76174809
78	MP0001905_abnormal_dopamine_level	0.75687128
79	MP0003635_abnormal_synaptic_transmissio	0.73814817
80	MP0005248_abnormal_Harderian_gland	0.73385584
81	MP0002210_abnormal_sex_determination	0.72834360
82	MP0002332_abnormal_exercise_endurance	0.72782798
83	MP0002063_abnormal_learning/memory/cond	0.72191089
84	MP0003938_abnormal_ear_development	0.70600606
85	MP0003936_abnormal_reproductive_system	0.70450585
86	MP0004019_abnormal_vitamin_homeostasis	0.68820174
87	MP0005332_abnormal_amino_acid	0.68745169
88	MP0003183_abnormal_peptide_metabolism	0.68521100
89	MP0002108_abnormal_muscle_morphology	0.68401429
90	MP0005076_abnormal_cell_differentiation	0.67663903
91	MP0003890_abnormal_embryonic-extraembry	0.66164075
92	MP0005377_hearing/vestibular/ear_phenot	0.64570046
93	MP0003878_abnormal_ear_physiology	0.64570046
94	MP0000467_abnormal_esophagus_morphology	0.63939251
95	MP0004264_abnormal_extraembryonic_tissu	0.63755396
96	MP0003186_abnormal_redox_activity	0.63663196
97	MP0002135_abnormal_kidney_morphology	0.63551286
98	MP0005266_abnormal_metabolism	0.62305786
99	MP0003935_abnormal_craniofacial_develop	0.58601231
100	MP0002234_abnormal_pharynx_morphology	0.56424719

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic pelvis (HP:0008839)	6.44730565
2	Cholecystitis (HP:0001082)	5.15747011
3	Abnormal gallbladder physiology (HP:0012438)	5.15747011
4	Stenosis of the external auditory canal (HP:0000402)	5.15128019
5	Tubulointerstitial nephritis (HP:0001970)	4.58968159
6	Gonadotropin excess (HP:0000837)	4.13504102
7	Chronic hepatic failure (HP:0100626)	3.56664232
8	Neonatal respiratory distress (HP:0002643)	3.38710168
9	Abnormal tarsal ossification (HP:0008369)	3.34290786
10	Renal cortical cysts (HP:0000803)	3.30435257
11	Rectal fistula (HP:0100590)	3.18790040
12	Rectovaginal fistula (HP:0000143)	3.18790040
13	Abnormal pancreas size (HP:0012094)	3.11581584
14	Abnormal biliary tract physiology (HP:0012439)	2.95665759
15	Bile duct proliferation (HP:0001408)	2.95665759
16	Small epiphyses (HP:0010585)	2.95161623
17	Fair hair (HP:0002286)	2.93099329
18	Vaginal fistula (HP:0004320)	2.91037641
19	Short 5th finger (HP:0009237)	2.89985184
20	Depressed nasal tip (HP:0000437)	2.84296845
21	Methylmalonic acidemia (HP:0002912)	2.80965744
22	Follicular hyperkeratosis (HP:0007502)	2.80596141
23	Barrel-shaped chest (HP:0001552)	2.76714845
24	Cupped ear (HP:0000378)	2.75929628
25	Renal dysplasia (HP:0000110)	2.74855277
26	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.69964864
27	Global brain atrophy (HP:0002283)	2.69250519
28	Cholelithiasis (HP:0001081)	2.67925444
29	Abnormal hair whorl (HP:0010721)	2.67593437
30	Hypoplasia of the odontoid process (HP:0003311)	2.67433678
31	Acute hepatic failure (HP:0006554)	2.63492198
32	Intestinal fistula (HP:0100819)	2.59301275
33	Osteomalacia (HP:0002749)	2.58131035
34	Poor eye contact (HP:0000817)	2.52594032
35	Abnormal gallbladder morphology (HP:0012437)	2.49491401
36	Molar tooth sign on MRI (HP:0002419)	2.47361302
37	Abnormality of midbrain morphology (HP:0002418)	2.47361302
38	Menstrual irregularities (HP:0000858)	2.47070091
39	High anterior hairline (HP:0009890)	2.45960421
40	Prominent supraorbital ridges (HP:0000336)	2.44221442
41	Tubulointerstitial abnormality (HP:0001969)	2.42790215
42	Carpal bone hypoplasia (HP:0001498)	2.41384561
43	Retinal atrophy (HP:0001105)	2.41185598
44	Gait imbalance (HP:0002141)	2.38903242
45	Congenital primary aphakia (HP:0007707)	2.35739201
46	Preauricular pit (HP:0004467)	2.35324437
47	Periauricular skin pits (HP:0100277)	2.35324437
48	Medial flaring of the eyebrow (HP:0010747)	2.31704086
49	Parakeratosis (HP:0001036)	2.29565918
50	Slender long bone (HP:0003100)	2.25373626
51	Nephrogenic diabetes insipidus (HP:0009806)	2.22371770
52	Abnormality of the renal cortex (HP:0011035)	2.21662780
53	Short foot (HP:0001773)	2.21466305
54	Absent speech (HP:0001344)	2.15201546
55	Vaginal atresia (HP:0000148)	2.12551972
56	Exocrine pancreatic insufficiency (HP:0001738)	2.11348138
57	Male infertility (HP:0003251)	2.11235121
58	Broad foot (HP:0001769)	2.10834020
59	Hypercholesterolemia (HP:0003124)	2.10552278
60	Methylmalonic aciduria (HP:0012120)	2.08993448
61	Abnormal foot bone ossification (HP:0010675)	2.07796678
62	Pendular nystagmus (HP:0012043)	2.07045672
63	Hip dysplasia (HP:0001385)	2.06975411
64	Genital tract atresia (HP:0001827)	2.06022455
65	Poikiloderma (HP:0001029)	2.05737779
66	Decreased testicular size (HP:0008734)	2.04217574
67	Ectropion (HP:0000656)	2.03455217
68	Spastic tetraparesis (HP:0001285)	2.02571646
69	Blue irides (HP:0000635)	2.02529738
70	Abnormality of the odontoid process (HP:0003310)	2.01553973
71	Alopecia of scalp (HP:0002293)	1.98889592
72	Hyperglycinemia (HP:0002154)	1.98025725
73	Increased corneal curvature (HP:0100692)	1.97071332
74	Keratoconus (HP:0000563)	1.97071332
75	Poor coordination (HP:0002370)	1.96173156
76	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89881244
77	Hyperventilation (HP:0002883)	1.89542222
78	Aortic valve stenosis (HP:0001650)	1.89375473
79	Everted lower lip vermilion (HP:0000232)	1.88994127
80	Diastasis recti (HP:0001540)	1.87735659
81	Abnormality of macular pigmentation (HP:0008002)	1.86076609
82	Protruding tongue (HP:0010808)	1.85800072
83	Septate vagina (HP:0001153)	1.84488599
84	Impaired social interactions (HP:0000735)	1.84444730
85	Abnormal social behavior (HP:0012433)	1.84444730
86	Unilateral renal agenesis (HP:0000122)	1.84099724
87	Vascular tortuosity (HP:0004948)	1.83369127
88	Renal tubular acidosis (HP:0001947)	1.81947032
89	Generalized hypopigmentation of hair (HP:0011358)	1.81493099
90	Proximal tubulopathy (HP:0000114)	1.79722800
91	Neoplasm of the heart (HP:0100544)	1.79409596
92	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.79219211
93	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.76840419
94	Tented upper lip vermilion (HP:0010804)	1.76520101
95	Irregular vertebral endplates (HP:0003301)	1.74741402
96	Abnormality of vitamin B metabolism (HP:0004340)	1.74000601
97	Pancreatic fibrosis (HP:0100732)	1.73737631
98	Flattened epiphyses (HP:0003071)	1.73655252
99	Entropion (HP:0000621)	1.73431365
100	Hypoplasia of the corpus callosum (HP:0002079)	1.72813854

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	7.43438977
2	EIF2AK3	7.31948448
3	BMPR1B	4.53073743
4	MUSK	3.92316776
5	ACVR1B	3.22675617
6	NUAK1	3.05919772
7	TGFBR1	2.36789200
8	MARK1	2.26028763
9	PRKD3	2.09925082
10	EIF2AK1	2.08193316
11	CCNB1	1.76398849
12	MKNK2	1.67203477
13	FRK	1.56794964
14	BUB1	1.50283798
15	MAP3K4	1.35867218
16	TYRO3	1.30997463
17	MAPK13	1.30992636
18	STK39	1.25903370
19	PLK2	1.24771817
20	PRPF4B	1.20462486
21	MAP3K6	1.10097960
22	MAP2K7	1.08448212
23	BCKDK	1.06664786
24	NLK	1.05429792
25	ADRBK2	1.00970742
26	TAOK2	0.99015845
27	DYRK1A	0.97129328
28	BRD4	0.95294203
29	YES1	0.86756082
30	OXSR1	0.83102716
31	MELK	0.82675987
32	CSNK1G1	0.82426608
33	NTRK2	0.80005735
34	STK3	0.79902050
35	PINK1	0.75664524
36	SIK2	0.72512269
37	EIF2AK2	0.71600176
38	BCR	0.71221779
39	MKNK1	0.68302228
40	MAP3K5	0.67962710
41	MAPK15	0.66236469
42	GRK5	0.61183061
43	PRKCE	0.59717379
44	ERBB3	0.59431497
45	LATS1	0.58588286
46	CDK8	0.57857887
47	PIM2	0.57153482
48	DMPK	0.55493356
49	SIK1	0.54156992
50	CSNK1G3	0.53711486
51	PAK6	0.53053177
52	MAP3K14	0.52307029
53	ILK	0.49982138
54	VRK1	0.49889316
55	ADRBK1	0.47937240
56	FES	0.47234947
57	VRK2	0.44966610
58	STK24	0.44656325
59	ROCK1	0.44325844
60	PAK2	0.43508064
61	PDGFRB	0.43394857
62	PLK1	0.43346405
63	ATM	0.43145819
64	PLK3	0.41271355
65	CASK	0.40495159
66	CSNK1A1L	0.39940070
67	PRKAA2	0.39146920
68	MAP2K4	0.37573778
69	FGFR1	0.36553613
70	CSNK1D	0.36009436
71	CDK9	0.35924538
72	SGK2	0.35342545
73	ATR	0.34697677
74	PRKCQ	0.34692823
75	PKN1	0.33658305
76	PRKCZ	0.30733904
77	ROCK2	0.30329877
78	PTK2B	0.30089995
79	CSNK1G2	0.29611116
80	GRK1	0.29421350
81	TSSK6	0.27759132
82	CSNK1A1	0.27291069
83	PRKACA	0.26380401
84	INSRR	0.25327718
85	CAMK2A	0.25061903
86	FLT3	0.24935154
87	PRKCG	0.24692439
88	MAPK8	0.24601844
89	MAP3K2	0.24333572
90	AKT2	0.24030195
91	PAK3	0.23968270
92	RPS6KA3	0.23613653
93	DYRK2	0.23285107
94	SGK223	0.22403300
95	SGK494	0.22403300
96	MAP2K1	0.21848371
97	ERBB4	0.21348305
98	INSR	0.21303357
99	MAP2K2	0.20998770
100	PIM1	0.20423403

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.28738291
2	Protein export_Homo sapiens_hsa03060	3.12688891
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.79791688
4	Folate biosynthesis_Homo sapiens_hsa00790	2.67309769
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.49685689
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.38875796
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38781618
8	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.30384518
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.29050549
10	ABC transporters_Homo sapiens_hsa02010	2.28460158
11	Pentose phosphate pathway_Homo sapiens_hsa00030	2.22929017
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.16697403
13	Phototransduction_Homo sapiens_hsa04744	2.12032213
14	RNA degradation_Homo sapiens_hsa03018	2.08971452
15	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.07938823
16	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.96687466
17	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.86356228
18	Propanoate metabolism_Homo sapiens_hsa00640	1.85429864
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.76808564
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68073174
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65642457
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48929227
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48097452
24	Peroxisome_Homo sapiens_hsa04146	1.46895702
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42571579
26	Butanoate metabolism_Homo sapiens_hsa00650	1.42279097
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.39805237
28	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.37124286
29	Fatty acid elongation_Homo sapiens_hsa00062	1.34375127
30	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.29595756
31	Carbon metabolism_Homo sapiens_hsa01200	1.23313706
32	Glutathione metabolism_Homo sapiens_hsa00480	1.22090507
33	Circadian rhythm_Homo sapiens_hsa04710	1.18961260
34	Basal transcription factors_Homo sapiens_hsa03022	1.17267287
35	Legionellosis_Homo sapiens_hsa05134	1.15937402
36	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.14405249
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10486568
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04556892
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.04430926
40	Bile secretion_Homo sapiens_hsa04976	1.04123123
41	Sulfur relay system_Homo sapiens_hsa04122	1.02785762
42	Prion diseases_Homo sapiens_hsa05020	0.99222644
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96303120
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95024608
45	Cocaine addiction_Homo sapiens_hsa05030	0.92907622
46	Long-term depression_Homo sapiens_hsa04730	0.89547682
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88214020
48	Regulation of autophagy_Homo sapiens_hsa04140	0.86066290
49	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.85853505
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.84633869
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.83357584
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77522597
53	Caffeine metabolism_Homo sapiens_hsa00232	0.75113757
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75017012
55	Axon guidance_Homo sapiens_hsa04360	0.74774586
56	Nicotine addiction_Homo sapiens_hsa05033	0.73609118
57	Serotonergic synapse_Homo sapiens_hsa04726	0.72047409
58	Olfactory transduction_Homo sapiens_hsa04740	0.71861419
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70920666
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.70199883
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67875741
62	Circadian entrainment_Homo sapiens_hsa04713	0.66418251
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66394805
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63158361
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62243891
66	Taste transduction_Homo sapiens_hsa04742	0.61741761
67	RNA transport_Homo sapiens_hsa03013	0.61644548
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61584794
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61473189
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61166282
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60754444
72	p53 signaling pathway_Homo sapiens_hsa04115	0.60169804
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.58140388
74	Ras signaling pathway_Homo sapiens_hsa04014	0.58008862
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57683727
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.57025688
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56730474
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.55583769
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53123456
80	RNA polymerase_Homo sapiens_hsa03020	0.53109083
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.47586159
82	GABAergic synapse_Homo sapiens_hsa04727	0.46909404
83	Morphine addiction_Homo sapiens_hsa05032	0.46302032
84	Adherens junction_Homo sapiens_hsa04520	0.45013098
85	Metabolic pathways_Homo sapiens_hsa01100	0.43169907
86	Mineral absorption_Homo sapiens_hsa04978	0.42946080
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42863420
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.40162593
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.37884594
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37801614
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37364269
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36656196
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35255929
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34371259
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.34208036
96	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.33875274
97	Galactose metabolism_Homo sapiens_hsa00052	0.32167424
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30130122
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28867494
100	Amphetamine addiction_Homo sapiens_hsa05031	0.28673197

RPL23AP36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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