RPL23AP37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation via MHC class Ib (GO:0002475)6.74417448
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.58809220
3regulation of isotype switching to IgG isotypes (GO:0048302)6.23641872
4DNA strand renaturation (GO:0000733)5.62043288
5DNA deamination (GO:0045006)5.42027596
6ribosomal small subunit biogenesis (GO:0042274)4.90509680
7ribosomal small subunit assembly (GO:0000028)4.47889358
8platelet dense granule organization (GO:0060155)4.41934787
9activated T cell proliferation (GO:0050798)4.32681796
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26243115
11proteasome assembly (GO:0043248)4.24947228
12positive regulation of isotype switching (GO:0045830)4.22169541
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19259353
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.15661007
15positive regulation of antigen processing and presentation (GO:0002579)4.08314100
16regulation of regulatory T cell differentiation (GO:0045589)3.96973754
17dopamine transport (GO:0015872)3.96547670
18positive regulation of DNA recombination (GO:0045911)3.95797463
19cytidine metabolic process (GO:0046087)3.86075756
20cytidine catabolic process (GO:0006216)3.86075756
21cytidine deamination (GO:0009972)3.86075756
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78509468
23ATP synthesis coupled proton transport (GO:0015986)3.78509468
24interferon-gamma production (GO:0032609)3.75849185
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68396980
26antigen processing and presentation of endogenous antigen (GO:0019883)3.67095023
27cellular response to exogenous dsRNA (GO:0071360)3.65483562
28positive regulation of B cell mediated immunity (GO:0002714)3.55658437
29positive regulation of immunoglobulin mediated immune response (GO:0002891)3.55658437
30positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.55553503
31adaptation of signaling pathway (GO:0023058)3.55326349
32protein neddylation (GO:0045116)3.54513665
33cellular response to interleukin-15 (GO:0071350)3.53637925
34immunoglobulin mediated immune response (GO:0016064)3.50805085
35T cell migration (GO:0072678)3.35712458
36mast cell activation involved in immune response (GO:0002279)3.33755717
37mast cell degranulation (GO:0043303)3.33755717
38viral transcription (GO:0019083)3.30916855
39cellular response to interferon-beta (GO:0035458)3.26645061
40pyrimidine ribonucleoside catabolic process (GO:0046133)3.23073459
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21830627
42mast cell activation (GO:0045576)3.19506820
43lymphocyte migration (GO:0072676)3.18207374
44B cell mediated immunity (GO:0019724)3.17473506
45positive regulation of defense response to virus by host (GO:0002230)3.17182044
46regulation of antigen processing and presentation (GO:0002577)3.16676604
47translational termination (GO:0006415)3.13321130
48regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.11624245
49translational elongation (GO:0006414)3.02165340
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96038923
51ncRNA 3-end processing (GO:0043628)2.96035575
52positive regulation of immunoglobulin production (GO:0002639)2.92095278
53regulation of chronic inflammatory response (GO:0002676)2.89197589
54response to interferon-beta (GO:0035456)2.89005619
55water-soluble vitamin biosynthetic process (GO:0042364)2.84684423
56positive regulation of natural killer cell mediated immunity (GO:0002717)2.82467603
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81916630
58regulation of immunoglobulin secretion (GO:0051023)2.81342658
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80668349
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80448513
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78863247
62lens fiber cell development (GO:0070307)2.78604676
63negative regulation of bone resorption (GO:0045779)2.78342304
64positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.78118315
65protein targeting to ER (GO:0045047)2.74242549
66cotranslational protein targeting to membrane (GO:0006613)2.72872281
67positive regulation of lymphocyte mediated immunity (GO:0002708)2.68941803
68positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66516540
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65467692
70positive regulation of B cell differentiation (GO:0045579)2.64692364
71behavioral response to nicotine (GO:0035095)2.64507558
72establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64115625
73maturation of SSU-rRNA (GO:0030490)2.64088237
74regulation of gamma-delta T cell differentiation (GO:0045586)2.63372786
75negative regulation of heart rate (GO:0010459)2.61708070
76positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.61537828
77ribonucleoprotein complex biogenesis (GO:0022613)2.59977894
78regulation of isotype switching (GO:0045191)2.59849818
79negative regulation of T-helper cell differentiation (GO:0045623)2.59569002
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59569002
81protein localization to endoplasmic reticulum (GO:0070972)2.59089599
82regulation of leukocyte mediated cytotoxicity (GO:0001910)2.56726140
83regulation of activation of Janus kinase activity (GO:0010533)2.56154135
84ATP biosynthetic process (GO:0006754)2.56043396
85response to interleukin-15 (GO:0070672)2.55216917
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.54089315
87intracellular protein transmembrane import (GO:0044743)2.53802349
88positive regulation of cell killing (GO:0031343)2.52422671
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51583705
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.50922552
91cellular component biogenesis (GO:0044085)2.50310994
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.48790784
93GTP biosynthetic process (GO:0006183)2.47901393
94fucose catabolic process (GO:0019317)2.45715302
95L-fucose metabolic process (GO:0042354)2.45715302
96L-fucose catabolic process (GO:0042355)2.45715302
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.45055021
98regulation of natural killer cell mediated immunity (GO:0002715)2.45055021
99positive regulation of adaptive immune response (GO:0002821)2.43079563
100cytolysis (GO:0019835)2.41491821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.67768613
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67747493
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.37309832
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.26542816
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.04700871
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89142862
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87415948
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47805015
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30980249
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25499429
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22677617
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22189647
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.15932866
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14827513
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.05458209
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.04148484
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03817280
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89277189
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88788162
20VDR_22108803_ChIP-Seq_LS180_Human1.86779937
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.79895112
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78552296
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73181877
24VDR_23849224_ChIP-Seq_CD4+_Human1.72700547
25ZNF274_21170338_ChIP-Seq_K562_Hela1.68818967
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67467320
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.66032013
28TP53_22573176_ChIP-Seq_HFKS_Human1.59139068
29GATA3_26560356_Chip-Seq_TH2_Human1.55947138
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53314823
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.52032346
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.50335849
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50335849
34RUNX_20019798_ChIP-Seq_JUKART_Human1.50045033
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46989916
36TAF2_19829295_ChIP-Seq_ESCs_Human1.45319807
37BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.42307118
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36866476
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36088584
40NCOR_22424771_ChIP-Seq_293T_Human1.35989115
41NANOG_20526341_ChIP-Seq_ESCs_Human1.34900788
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34601495
43NANOG_19829295_ChIP-Seq_ESCs_Human1.34063732
44SOX2_19829295_ChIP-Seq_ESCs_Human1.34063732
45EWS_26573619_Chip-Seq_HEK293_Human1.32880586
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32267080
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30747084
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26466094
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26039993
50AR_20517297_ChIP-Seq_VCAP_Human1.25837721
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23906042
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21476308
53FOXP3_21729870_ChIP-Seq_TREG_Human1.21128343
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.18495248
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16906068
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16402065
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.15783918
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13532579
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13123596
60MYB_26560356_Chip-Seq_TH2_Human1.12927746
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.12427659
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12279647
63BCL6_27268052_Chip-Seq_Bcells_Human1.11665186
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11182028
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10960794
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10473344
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09950465
68ELK1_19687146_ChIP-ChIP_HELA_Human1.08556101
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08252319
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06155793
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05640427
72MYC_18940864_ChIP-ChIP_HL60_Human1.05458684
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03201097
74GATA6_21074721_ChIP-Seq_CACO-2_Human1.03197887
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01807677
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.01551220
77EGR1_19032775_ChIP-ChIP_M12_Human1.01169050
78RBPJ_21746931_ChIP-Seq_IB4_Human1.00995652
79ERA_21632823_ChIP-Seq_H3396_Human0.99703517
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98941241
81CTCF_20526341_ChIP-Seq_ESCs_Human0.98933642
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98849489
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97463559
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96681119
85HOXB7_26014856_ChIP-Seq_BT474_Human0.94210458
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94094929
87P53_21459846_ChIP-Seq_SAOS-2_Human0.93916842
88GATA3_26560356_Chip-Seq_TH1_Human0.93806446
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93007894
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92795420
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92355738
92GATA3_27048872_Chip-Seq_THYMUS_Human0.92352906
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91585603
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90422616
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.90284913
96PHF8_20622853_ChIP-Seq_HELA_Human0.90132281
97P300_27268052_Chip-Seq_Bcells_Human0.89799864
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.89011379
99ETV1_20927104_ChIP-Seq_GIST48_Human0.87333259
100BCAT_22108803_ChIP-Seq_LS180_Human0.86328911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.14122174
2MP0001835_abnormal_antigen_presentation4.63982948
3MP0006082_CNS_inflammation4.22842648
4MP0001873_stomach_inflammation3.57023490
5MP0002102_abnormal_ear_morphology3.35831802
6MP0005377_hearing/vestibular/ear_phenot3.02234048
7MP0003878_abnormal_ear_physiology3.02234048
8MP0000685_abnormal_immune_system2.84512525
9MP0003879_abnormal_hair_cell2.48363544
10MP0002132_abnormal_respiratory_system2.44543560
11MP0002166_altered_tumor_susceptibility2.37596519
12MP0001800_abnormal_humoral_immune2.19336843
13MP0002163_abnormal_gland_morphology2.03732494
14MP0005000_abnormal_immune_tolerance1.94726503
15MP0009333_abnormal_splenocyte_physiolog1.91800386
16MP0005464_abnormal_platelet_physiology1.91416614
17MP0009785_altered_susceptibility_to1.90995476
18MP0002148_abnormal_hypersensitivity_rea1.90593123
19MP0002006_tumorigenesis1.85015602
20MP0010155_abnormal_intestine_physiology1.79724318
21MP0001790_abnormal_immune_system1.72444694
22MP0005387_immune_system_phenotype1.72444694
23MP0003866_abnormal_defecation1.70319009
24MP0002933_joint_inflammation1.68925484
25MP0008872_abnormal_physiological_respon1.68413076
26MP0008875_abnormal_xenobiotic_pharmacok1.67109080
27MP0002723_abnormal_immune_serum1.65343289
28MP0005075_abnormal_melanosome_morpholog1.65275476
29MP0002138_abnormal_hepatobiliary_system1.58364430
30MP0002420_abnormal_adaptive_immunity1.56604878
31MP0001968_abnormal_touch/_nociception1.54465814
32MP0001819_abnormal_immune_cell1.53880051
33MP0002736_abnormal_nociception_after1.52981153
34MP0000372_irregular_coat_pigmentation1.52501587
35MP0005025_abnormal_response_to1.51418849
36MP0002452_abnormal_antigen_presenting1.50613758
37MP0008877_abnormal_DNA_methylation1.46970603
38MP0004142_abnormal_muscle_tone1.44259266
39MP0003763_abnormal_thymus_physiology1.39502097
40MP0003195_calcinosis1.34671014
41MP0005646_abnormal_pituitary_gland1.34096748
42MP0004885_abnormal_endolymph1.31855677
43MP0002405_respiratory_system_inflammati1.30786378
44MP0002837_dystrophic_cardiac_calcinosis1.26486260
45MP0002876_abnormal_thyroid_physiology1.26322727
46MP0001845_abnormal_inflammatory_respons1.25555062
47MP0001663_abnormal_digestive_system1.23382673
48MP0005379_endocrine/exocrine_gland_phen1.22592709
49MP0005408_hypopigmentation1.22418563
50MP0005551_abnormal_eye_electrophysiolog1.21137493
51MP0001905_abnormal_dopamine_level1.20686934
52MP0005645_abnormal_hypothalamus_physiol1.20642225
53MP0002398_abnormal_bone_marrow1.18319982
54MP0000716_abnormal_immune_system1.16394112
55MP0003724_increased_susceptibility_to1.13990778
56MP0009764_decreased_sensitivity_to1.13320615
57MP0001727_abnormal_embryo_implantation1.10707733
58MP0004145_abnormal_muscle_electrophysio1.10683474
59MP0003646_muscle_fatigue1.08847061
60MP0003718_maternal_effect1.08488464
61MP0006292_abnormal_olfactory_placode1.07488739
62MP0002419_abnormal_innate_immunity1.07116392
63MP0003786_premature_aging1.04087902
64MP0006072_abnormal_retinal_apoptosis1.02457349
65MP0009379_abnormal_foot_pigmentation1.01553296
66MP0005410_abnormal_fertilization1.00954904
67MP0008469_abnormal_protein_level1.00409204
68MP0000689_abnormal_spleen_morphology1.00253386
69MP0001485_abnormal_pinna_reflex1.00232758
70MP0004742_abnormal_vestibular_system1.00008222
71MP0004510_myositis0.98459060
72MP0000703_abnormal_thymus_morphology0.94714045
73MP0005084_abnormal_gallbladder_morpholo0.94487756
74MP0002722_abnormal_immune_system0.94203208
75MP0002429_abnormal_blood_cell0.92663528
76MP0001986_abnormal_taste_sensitivity0.92230551
77MP0003252_abnormal_bile_duct0.88742040
78MP0001919_abnormal_reproductive_system0.81618053
79MP0004381_abnormal_hair_follicle0.80143237
80MP0005389_reproductive_system_phenotype0.79291020
81MP0002277_abnormal_respiratory_mucosa0.79090831
82MP0005360_urolithiasis0.78145052
83MP0005167_abnormal_blood-brain_barrier0.77809573
84MP0000230_abnormal_systemic_arterial0.75872995
85MP0005381_digestive/alimentary_phenotyp0.75587571
86MP0003638_abnormal_response/metabolism_0.75244712
87MP0002272_abnormal_nervous_system0.74672754
88MP0004084_abnormal_cardiac_muscle0.74500427
89MP0000465_gastrointestinal_hemorrhage0.72855942
90MP0002693_abnormal_pancreas_physiology0.72803100
91MP0002822_catalepsy0.72698805
92MP0005253_abnormal_eye_physiology0.72021588
93MP0001853_heart_inflammation0.71863071
94MP0002638_abnormal_pupillary_reflex0.71797433
95MP0008775_abnormal_heart_ventricle0.69354849
96MP0000858_altered_metastatic_potential0.68336531
97MP0001486_abnormal_startle_reflex0.63946172
98MP0009745_abnormal_behavioral_response0.63530803
99MP0004147_increased_porphyrin_level0.62682597
100MP0009697_abnormal_copulation0.62428216

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.83627490
2Nasal polyposis (HP:0100582)6.09740397
3Chronic otitis media (HP:0000389)5.07307120
4Abnormality of the nasal mucosa (HP:0000433)5.02511143
5Muscle fiber atrophy (HP:0100295)4.41117821
6Abnormality of macular pigmentation (HP:0008002)4.26911333
73-Methylglutaconic aciduria (HP:0003535)3.85724584
8Stomatitis (HP:0010280)3.77335066
9Increased IgM level (HP:0003496)3.76351054
10Chronic sinusitis (HP:0011109)3.73591642
11IgG deficiency (HP:0004315)3.72668804
12Hypoproteinemia (HP:0003075)3.70219889
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.57511963
14Recurrent bronchitis (HP:0002837)3.14836221
15Abnormality of T cell physiology (HP:0011840)3.02616629
16Constricted visual fields (HP:0001133)2.98054587
17Abnormality of T cells (HP:0002843)2.93778689
18Attenuation of retinal blood vessels (HP:0007843)2.83967009
19Acute necrotizing encephalopathy (HP:0006965)2.80442383
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67426813
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67426813
22Congenital stationary night blindness (HP:0007642)2.67402001
23Hypergammaglobulinemia (HP:0010702)2.54592720
24Flat capital femoral epiphysis (HP:0003370)2.50754270
25Optic disc pallor (HP:0000543)2.50053147
26Abnormal mitochondria in muscle tissue (HP:0008316)2.46371549
27Progressive macrocephaly (HP:0004481)2.43630806
28Abolished electroretinogram (ERG) (HP:0000550)2.42467047
29Mitochondrial inheritance (HP:0001427)2.40055884
30Large eyes (HP:0001090)2.39566980
31Abnormality of T cell number (HP:0011839)2.35545385
32Aplastic anemia (HP:0001915)2.28863068
33Acute encephalopathy (HP:0006846)2.28186237
34Encephalitis (HP:0002383)2.26740533
35Congenital, generalized hypertrichosis (HP:0004540)2.25834472
36Bronchitis (HP:0012387)2.24313365
37Increased CSF lactate (HP:0002490)2.23255994
38Hypoplasia of the uterus (HP:0000013)2.22782459
39Abnormality of the renal cortex (HP:0011035)2.22270377
40Esophageal atresia (HP:0002032)2.21314614
41Aplasia/hypoplasia of the uterus (HP:0008684)2.21102299
42Abnormality of midbrain morphology (HP:0002418)2.19487777
43Molar tooth sign on MRI (HP:0002419)2.19487777
44Reduced subcutaneous adipose tissue (HP:0003758)2.17308285
45Pancreatic cysts (HP:0001737)2.15942727
46T lymphocytopenia (HP:0005403)2.15692020
47Type 2 muscle fiber atrophy (HP:0003554)2.12761271
48Shawl scrotum (HP:0000049)2.12294917
49Severe visual impairment (HP:0001141)2.03655335
50Delayed CNS myelination (HP:0002188)2.00528610
51Thrombocytosis (HP:0001894)1.98959944
52Striae distensae (HP:0001065)1.98143086
53Hemiplegia (HP:0002301)1.96573574
54Polydipsia (HP:0001959)1.96539335
55Abnormal drinking behavior (HP:0030082)1.96539335
56Zonular cataract (HP:0010920)1.94662854
57Respiratory difficulties (HP:0002880)1.94642255
58Large earlobe (HP:0009748)1.93881283
59Bronchiectasis (HP:0002110)1.91824663
60Chronic diarrhea (HP:0002028)1.89079298
61Polyuria (HP:0000103)1.88785200
62Myositis (HP:0100614)1.87360849
63Abnormality of eosinophils (HP:0001879)1.86199453
64Autoimmune hemolytic anemia (HP:0001890)1.85856319
65Large for gestational age (HP:0001520)1.84956445
66Macrocytic anemia (HP:0001972)1.84902755
67Renal Fanconi syndrome (HP:0001994)1.84857088
68Abnormality of the prostate (HP:0008775)1.84056283
69Atrioventricular block (HP:0001678)1.83234973
70Hepatocellular necrosis (HP:0001404)1.83009711
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82578754
72Abnormality of alanine metabolism (HP:0010916)1.82578754
73Hyperalaninemia (HP:0003348)1.82578754
74Conical tooth (HP:0000698)1.81975918
75Thyroiditis (HP:0100646)1.81604471
76Exertional dyspnea (HP:0002875)1.80542954
77Decreased central vision (HP:0007663)1.80170500
78Pancytopenia (HP:0001876)1.78787291
79Abnormality of cells of the erythroid lineage (HP:0012130)1.77257259
80Type II lissencephaly (HP:0007260)1.75882929
81Increased intramyocellular lipid droplets (HP:0012240)1.75207202
82Abnormal rod and cone electroretinograms (HP:0008323)1.75067044
83Abnormal number of erythroid precursors (HP:0012131)1.74959308
84Abnormality of pyrimidine metabolism (HP:0004353)1.74798241
85Heart block (HP:0012722)1.73806951
86Renal cortical cysts (HP:0000803)1.73793908
87Eosinophilia (HP:0001880)1.71589982
88Hypokalemic alkalosis (HP:0001949)1.71239404
89Erythema (HP:0010783)1.70396650
90Increased hepatocellular lipid droplets (HP:0006565)1.70049881
91Nephronophthisis (HP:0000090)1.69930151
92Hepatic necrosis (HP:0002605)1.69219835
93Metabolic alkalosis (HP:0200114)1.68728374
94Methylmalonic acidemia (HP:0002912)1.67589768
95Clubbing of toes (HP:0100760)1.67130993
96Pancreatic fibrosis (HP:0100732)1.67053033
97Increased serum lactate (HP:0002151)1.65503780
98Abnormality of the renal medulla (HP:0100957)1.65463304
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65259256
100Severe combined immunodeficiency (HP:0004430)1.64924065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.78825030
2KIT3.22191064
3GRK73.10298343
4ITK2.99697171
5MAP4K22.96876849
6FES2.68707284
7TLK12.65424970
8TEC2.43424256
9TGFBR22.37163047
10ADRBK22.22366931
11NUAK12.14636116
12GRK52.07046939
13MAP4K12.00658375
14GRK11.99561762
15WNK41.99079378
16MOS1.99077210
17SYK1.79310448
18FRK1.77941873
19BCKDK1.77247012
20KDR1.74208055
21NME21.71168123
22TAOK31.69015918
23IKBKB1.66993666
24PINK11.65923799
25MAP3K121.54408461
26PTK2B1.53913043
27STK101.53564476
28ZAK1.46675310
29BTK1.41999876
30MYLK1.36056601
31ZAP701.35678317
32MST41.30570322
33GRK61.16217800
34ADRBK11.15685720
35LCK1.10416264
36STK391.08168599
37WNK31.07742183
38BUB11.06144408
39INSRR1.03725652
40EIF2AK21.02723693
41BMPR1B1.01606485
42PRKCQ1.00788915
43TIE10.96176112
44VRK10.95203976
45PIM10.86069213
46HCK0.85504206
47IKBKE0.85273621
48OXSR10.83660069
49VRK20.83218384
50PASK0.81117321
51CSK0.81043916
52RPS6KA50.80422739
53LRRK20.79652228
54LYN0.77095514
55DAPK10.74979433
56TBK10.74782698
57PIK3CA0.71479174
58MAPKAPK30.70728055
59CSF1R0.69315648
60PHKG20.63152893
61PHKG10.63152893
62TRIM280.61901469
63STK160.61313511
64PRKCG0.58884615
65PRKG20.58289250
66CDK190.57990571
67OBSCN0.57564965
68PRKCD0.56719843
69JAK30.55040879
70PRKACA0.53712797
71AKT30.49644455
72IGF1R0.48854605
73TSSK60.47650406
74CAMKK20.47517631
75MAP3K140.47147435
76CLK10.46660344
77CDK40.46468961
78DAPK20.44580243
79DYRK20.44411421
80NEK10.43831743
81PRKCA0.43647464
82ILK0.40460228
83DAPK30.40259104
84CSNK1A10.39554380
85ABL10.39348685
86BMPR20.38281251
87PRKCB0.36915922
88MAPK130.36694066
89MARK30.36485130
90NME10.36195565
91FLT30.35727191
92INSR0.35463929
93MAP2K60.34933399
94CHEK20.34558817
95PLK30.33507183
96MAPKAPK50.33493419
97PRKACG0.33177992
98TESK20.32081416
99AURKA0.31321968
100PRKCE0.30493664

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.88455256
2Primary immunodeficiency_Homo sapiens_hsa053403.58912161
3Allograft rejection_Homo sapiens_hsa053303.55556304
4Ribosome_Homo sapiens_hsa030103.43853365
5Autoimmune thyroid disease_Homo sapiens_hsa053203.30966789
6Asthma_Homo sapiens_hsa053103.28757713
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.02043748
8Proteasome_Homo sapiens_hsa030502.92143189
9Oxidative phosphorylation_Homo sapiens_hsa001902.73624562
10Type I diabetes mellitus_Homo sapiens_hsa049402.67036690
11Antigen processing and presentation_Homo sapiens_hsa046122.61635691
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37785983
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13821219
14Parkinsons disease_Homo sapiens_hsa050122.04047328
15Phototransduction_Homo sapiens_hsa047441.87691937
16Hematopoietic cell lineage_Homo sapiens_hsa046401.79959290
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75525359
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67272500
19RNA polymerase_Homo sapiens_hsa030201.56909355
20Rheumatoid arthritis_Homo sapiens_hsa053231.53087810
21Basal transcription factors_Homo sapiens_hsa030221.50637487
22Protein export_Homo sapiens_hsa030601.45616086
23Viral myocarditis_Homo sapiens_hsa054161.43126953
24Linoleic acid metabolism_Homo sapiens_hsa005911.32225545
25Huntingtons disease_Homo sapiens_hsa050161.28485068
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24560903
27One carbon pool by folate_Homo sapiens_hsa006701.22755821
28Alzheimers disease_Homo sapiens_hsa050101.22446160
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19386159
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17635724
31RNA degradation_Homo sapiens_hsa030181.14999951
32Cardiac muscle contraction_Homo sapiens_hsa042601.13226468
33Staphylococcus aureus infection_Homo sapiens_hsa051501.11234347
34T cell receptor signaling pathway_Homo sapiens_hsa046601.09045087
35Nitrogen metabolism_Homo sapiens_hsa009101.07285060
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05250964
37Systemic lupus erythematosus_Homo sapiens_hsa053221.04256131
38Sulfur metabolism_Homo sapiens_hsa009201.02942193
39Pyrimidine metabolism_Homo sapiens_hsa002401.02654729
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00727349
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00533537
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.94513733
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.92493034
44Caffeine metabolism_Homo sapiens_hsa002320.91766167
45beta-Alanine metabolism_Homo sapiens_hsa004100.90617786
46Olfactory transduction_Homo sapiens_hsa047400.81149521
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80325841
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79998669
49Arachidonic acid metabolism_Homo sapiens_hsa005900.77809245
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77338981
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75531842
52ABC transporters_Homo sapiens_hsa020100.73143664
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.71792322
54Retinol metabolism_Homo sapiens_hsa008300.69313737
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.69238616
56Peroxisome_Homo sapiens_hsa041460.68074829
57Homologous recombination_Homo sapiens_hsa034400.67431872
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67116406
59Chemical carcinogenesis_Homo sapiens_hsa052040.66513252
60Purine metabolism_Homo sapiens_hsa002300.63703594
61Measles_Homo sapiens_hsa051620.62962531
62Leishmaniasis_Homo sapiens_hsa051400.62044699
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59842000
64Malaria_Homo sapiens_hsa051440.59616756
65Herpes simplex infection_Homo sapiens_hsa051680.57852433
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57210383
67Arginine and proline metabolism_Homo sapiens_hsa003300.50481261
68Glycerolipid metabolism_Homo sapiens_hsa005610.50160323
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49571333
70Histidine metabolism_Homo sapiens_hsa003400.49519699
71Salivary secretion_Homo sapiens_hsa049700.49314750
72Tryptophan metabolism_Homo sapiens_hsa003800.45427109
73Spliceosome_Homo sapiens_hsa030400.44836469
74Fanconi anemia pathway_Homo sapiens_hsa034600.43229060
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.42636231
76Collecting duct acid secretion_Homo sapiens_hsa049660.42512374
77Regulation of autophagy_Homo sapiens_hsa041400.41504551
78Fat digestion and absorption_Homo sapiens_hsa049750.39719676
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37752673
80Ether lipid metabolism_Homo sapiens_hsa005650.37164108
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37012881
82Nicotine addiction_Homo sapiens_hsa050330.35144750
83Mismatch repair_Homo sapiens_hsa034300.35123014
84Metabolic pathways_Homo sapiens_hsa011000.34730623
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34073514
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32631250
87Tyrosine metabolism_Homo sapiens_hsa003500.29086216
88Selenocompound metabolism_Homo sapiens_hsa004500.28835789
89Mineral absorption_Homo sapiens_hsa049780.27578401
90Base excision repair_Homo sapiens_hsa034100.26466682
91Taste transduction_Homo sapiens_hsa047420.25783235
92Nucleotide excision repair_Homo sapiens_hsa034200.25571084
93Propanoate metabolism_Homo sapiens_hsa006400.23689262
94Morphine addiction_Homo sapiens_hsa050320.23426682
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22091965
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20193539
97Serotonergic synapse_Homo sapiens_hsa047260.20118183
98Butanoate metabolism_Homo sapiens_hsa006500.18279348
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18085089
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17290448

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »