ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.51363517
2	maturation of 5.8S rRNA (GO:0000460)	5.37991923
3	ribosomal small subunit assembly (GO:0000028)	4.81089883
4	ATP synthesis coupled proton transport (GO:0015986)	4.37593329
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.37593329
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.33650691
7	cytochrome complex assembly (GO:0017004)	4.21394626
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.17080197
9	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	4.14222164
10	regulation of activation of Janus kinase activity (GO:0010533)	4.11193902
11	kynurenine metabolic process (GO:0070189)	4.04337047
12	positive regulation of translational initiation (GO:0045948)	3.99030627
13	regulation of isotype switching to IgG isotypes (GO:0048302)	3.94234997
14	negative regulation of mast cell activation (GO:0033004)	3.91846609
15	cellular response to interleukin-15 (GO:0071350)	3.82733784
16	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.71113070
17	cytidine metabolic process (GO:0046087)	3.65404903
18	cytidine catabolic process (GO:0006216)	3.65404903
19	cytidine deamination (GO:0009972)	3.65404903
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.64144685
21	platelet dense granule organization (GO:0060155)	3.63650912
22	protein complex biogenesis (GO:0070271)	3.46844747
23	indole-containing compound catabolic process (GO:0042436)	3.42957035
24	indolalkylamine catabolic process (GO:0046218)	3.42957035
25	tryptophan catabolic process (GO:0006569)	3.42957035
26	negative regulation of telomere maintenance (GO:0032205)	3.40923911
27	purine ribonucleotide transport (GO:0015868)	3.39539411
28	nucleotide transmembrane transport (GO:1901679)	3.35089945
29	adenine nucleotide transport (GO:0051503)	3.33670575
30	regulation of B cell receptor signaling pathway (GO:0050855)	3.32345942
31	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.31418351
32	viral transcription (GO:0019083)	3.31329372
33	RNA localization (GO:0006403)	3.26482430
34	pseudouridine synthesis (GO:0001522)	3.24519076
35	response to interferon-beta (GO:0035456)	3.24031272
36	respiratory chain complex IV assembly (GO:0008535)	3.22494552
37	regulation of mitochondrial translation (GO:0070129)	3.21355762
38	positive regulation of T-helper 1 type immune response (GO:0002827)	3.20939960
39	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.19965210
40	positive thymic T cell selection (GO:0045059)	3.15560615
41	translational termination (GO:0006415)	3.15314897
42	tryptophan metabolic process (GO:0006568)	3.14835475
43	secretory granule organization (GO:0033363)	3.13772697
44	regulation of regulatory T cell differentiation (GO:0045589)	3.10019176
45	positive regulation of prostaglandin secretion (GO:0032308)	3.09265361
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08982029
47	protein neddylation (GO:0045116)	3.08625013
48	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.08475184
49	positive regulation of signal transduction by p53 class mediator (GO:1901798)	3.06387161
50	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.02983615
51	rRNA catabolic process (GO:0016075)	3.01879355
52	piRNA metabolic process (GO:0034587)	2.99427821
53	organic cation transport (GO:0015695)	2.97577536
54	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.96009384
55	nucleoside transmembrane transport (GO:1901642)	2.95797892
56	positive T cell selection (GO:0043368)	2.94929614
57	positive regulation of fatty acid transport (GO:2000193)	2.93886990
58	response to interleukin-15 (GO:0070672)	2.90924184
59	multicellular organism reproduction (GO:0032504)	2.90911777
60	cellular response to interferon-beta (GO:0035458)	2.89886266
61	response to pheromone (GO:0019236)	2.89108985
62	regulation of T cell mediated cytotoxicity (GO:0001914)	2.86020415
63	megakaryocyte development (GO:0035855)	2.84800277
64	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.84272443
65	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.83885914
66	regulation of gamma-delta T cell differentiation (GO:0045586)	2.83848671
67	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.82974992
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.81437974
69	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.80912063
70	negative regulation of phagocytosis (GO:0050765)	2.79913270
71	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.77703349
72	indolalkylamine metabolic process (GO:0006586)	2.76678079
73	positive regulation of icosanoid secretion (GO:0032305)	2.76457487
74	translational elongation (GO:0006414)	2.76381680
75	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.76247266
76	negative T cell selection (GO:0043383)	2.75136369
77	cellular response to ATP (GO:0071318)	2.72657818
78	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.71212706
79	negative regulation of cell killing (GO:0031342)	2.71212706
80	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.70839164
81	cotranslational protein targeting to membrane (GO:0006613)	2.68387048
82	positive regulation of gamma-delta T cell activation (GO:0046645)	2.68056026
83	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.67037732
84	isotype switching (GO:0045190)	2.67037732
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.67037732
86	protein targeting to ER (GO:0045047)	2.66460014
87	regulation of T-helper 1 type immune response (GO:0002825)	2.64421391
88	T cell selection (GO:0045058)	2.63999675
89	thymic T cell selection (GO:0045061)	2.63120352
90	ATP biosynthetic process (GO:0006754)	2.63054988
91	protein localization to endoplasmic reticulum (GO:0070972)	2.60851459
92	regulation of natural killer cell mediated immunity (GO:0002715)	2.59615702
93	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.59615702
94	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.58303509
95	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.57597761
96	negative thymic T cell selection (GO:0045060)	2.57424724
97	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.57046866
98	metallo-sulfur cluster assembly (GO:0031163)	2.57017593
99	iron-sulfur cluster assembly (GO:0016226)	2.57017593
100	purine nucleotide transport (GO:0015865)	2.56370802

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.87938298
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.55208643
3	VDR_22108803_ChIP-Seq_LS180_Human	3.29569231
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.92507721
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.86918495
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69869514
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.63625131
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.57063651
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.57016347
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.56524056
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.51824632
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.49271682
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42297699
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32738373
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.29968352
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.28738687
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.25413795
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.22776810
19	GATA3_26560356_Chip-Seq_TH2_Human	2.18646490
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.14369065
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.09066952
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.02449974
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86905946
24	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.82028108
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78130909
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76439831
27	AR_20517297_ChIP-Seq_VCAP_Human	1.75834726
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.74318684
29	MYB_26560356_Chip-Seq_TH2_Human	1.70157590
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67012004
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.64883082
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63651816
33	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.63028339
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.60389558
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.60389558
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58861929
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56852225
38	RUNX_20019798_ChIP-Seq_JUKART_Human	1.54007526
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.53517158
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.46166845
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44899317
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43627305
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42089824
44	EGR1_19032775_ChIP-ChIP_M12_Human	1.41384996
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37225242
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37129730
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.37093582
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35639770
49	NCOR_22424771_ChIP-Seq_293T_Human	1.35601494
50	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34891301
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34552436
52	GATA1_22025678_ChIP-Seq_K562_Human	1.34067867
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.32732996
54	ERA_21632823_ChIP-Seq_H3396_Human	1.27239565
55	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.27061947
56	P300_27268052_Chip-Seq_Bcells_Human	1.26463490
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25566147
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25446169
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24895347
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24124086
61	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.22452432
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20595751
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20041935
64	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.19413871
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19261952
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19081226
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19081226
68	OCT4_20526341_ChIP-Seq_ESCs_Human	1.17542161
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.15742317
70	GATA3_26560356_Chip-Seq_TH1_Human	1.15623612
71	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.14611244
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13476974
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11656740
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11632385
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11466166
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11035875
77	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07599882
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.07462820
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07243407
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.05738978
81	BCL6_27268052_Chip-Seq_Bcells_Human	1.05185240
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05035245
83	RAC3_21632823_ChIP-Seq_H3396_Human	1.04793544
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03267373
85	STAT1_20625510_ChIP-Seq_HELA_Human	1.03027929
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02324143
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00854332
88	GATA3_27048872_Chip-Seq_THYMUS_Human	1.00123412
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99875981
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99162934
91	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.99134852
92	E2F1_20622854_ChIP-Seq_HELA_Human	0.98583194
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98264850
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.98060307
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97325215
96	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97028459
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96441046
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95688406
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95389814
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94001774

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.72907983
2	MP0005671_abnormal_response_to	3.68443838
3	MP0001835_abnormal_antigen_presentation	3.15787629
4	MP0004147_increased_porphyrin_level	2.97976936
5	MP0008875_abnormal_xenobiotic_pharmacok	2.69347984
6	MP0006072_abnormal_retinal_apoptosis	2.56464046
7	MP0000372_irregular_coat_pigmentation	2.39733413
8	MP0003011_delayed_dark_adaptation	2.37006315
9	MP0001800_abnormal_humoral_immune	2.16301683
10	MP0009764_decreased_sensitivity_to	2.10315656
11	MP0000685_abnormal_immune_system	2.09766309
12	MP0002148_abnormal_hypersensitivity_rea	2.07437832
13	MP0005000_abnormal_immune_tolerance	2.07357263
14	MP0002006_tumorigenesis	2.06070911
15	MP0002166_altered_tumor_susceptibility	2.05639171
16	MP0005075_abnormal_melanosome_morpholog	2.03016085
17	MP0009333_abnormal_splenocyte_physiolog	1.96888381
18	MP0006292_abnormal_olfactory_placode	1.96562676
19	MP0008872_abnormal_physiological_respon	1.93488851
20	MP0003195_calcinosis	1.90438170
21	MP0002723_abnormal_immune_serum	1.87649461
22	MP0005387_immune_system_phenotype	1.85367418
23	MP0001790_abnormal_immune_system	1.85367418
24	MP0003724_increased_susceptibility_to	1.83956843
25	MP0008877_abnormal_DNA_methylation	1.81768004
26	MP0004885_abnormal_endolymph	1.74631844
27	MP0009785_altered_susceptibility_to	1.74406343
28	MP0003436_decreased_susceptibility_to	1.72188701
29	MP0002102_abnormal_ear_morphology	1.70789265
30	MP0004782_abnormal_surfactant_physiolog	1.70598723
31	MP0002163_abnormal_gland_morphology	1.69629767
32	MP0005551_abnormal_eye_electrophysiolog	1.67416689
33	MP0005253_abnormal_eye_physiology	1.65452354
34	MP0002452_abnormal_antigen_presenting	1.62202198
35	MP0001819_abnormal_immune_cell	1.61543231
36	MP0002420_abnormal_adaptive_immunity	1.61026801
37	MP0002876_abnormal_thyroid_physiology	1.60487935
38	MP0001873_stomach_inflammation	1.58087963
39	MP0004145_abnormal_muscle_electrophysio	1.52269240
40	MP0001986_abnormal_taste_sensitivity	1.48126475
41	MP0005025_abnormal_response_to	1.47072180
42	MP0005646_abnormal_pituitary_gland	1.46229189
43	MP0002837_dystrophic_cardiac_calcinosis	1.40327542
44	MP0001968_abnormal_touch/_nociception	1.37715698
45	MP0005085_abnormal_gallbladder_physiolo	1.36323539
46	MP0003763_abnormal_thymus_physiology	1.34239832
47	MP0006082_CNS_inflammation	1.32640454
48	MP0004043_abnormal_pH_regulation	1.31609622
49	MP0005389_reproductive_system_phenotype	1.28373690
50	MP0002653_abnormal_ependyma_morphology	1.28290860
51	MP0010155_abnormal_intestine_physiology	1.25954559
52	MP0006036_abnormal_mitochondrial_physio	1.22593639
53	MP0005410_abnormal_fertilization	1.18892880
54	MP0001919_abnormal_reproductive_system	1.18213642
55	MP0002398_abnormal_bone_marrow	1.17738318
56	MP0000716_abnormal_immune_system	1.15177353
57	MP0000689_abnormal_spleen_morphology	1.14323691
58	MP0002736_abnormal_nociception_after	1.11171845
59	MP0002095_abnormal_skin_pigmentation	1.10318911
60	MP0001845_abnormal_inflammatory_respons	1.10187656
61	MP0002277_abnormal_respiratory_mucosa	1.08942248
62	MP0002638_abnormal_pupillary_reflex	1.04396594
63	MP0002722_abnormal_immune_system	1.00834744
64	MP0003866_abnormal_defecation	1.00285531
65	MP0002419_abnormal_innate_immunity	0.96594448
66	MP0003786_premature_aging	0.94604931
67	MP0008775_abnormal_heart_ventricle	0.93389685
68	MP0001533_abnormal_skeleton_physiology	0.92967788
69	MP0002429_abnormal_blood_cell	0.92690367
70	MP0003806_abnormal_nucleotide_metabolis	0.92125752
71	MP0005379_endocrine/exocrine_gland_phen	0.91084246
72	MP0000703_abnormal_thymus_morphology	0.90970852
73	MP0002138_abnormal_hepatobiliary_system	0.90935246
74	MP0005645_abnormal_hypothalamus_physiol	0.90247421
75	MP0004142_abnormal_muscle_tone	0.90100169
76	MP0005084_abnormal_gallbladder_morpholo	0.89874054
77	MP0002332_abnormal_exercise_endurance	0.88732612
78	MP0001661_extended_life_span	0.88625525
79	MP0004381_abnormal_hair_follicle	0.86114372
80	MP0000427_abnormal_hair_cycle	0.82890037
81	MP0009046_muscle_twitch	0.81216155
82	MP0008469_abnormal_protein_level	0.81190401
83	MP0005636_abnormal_mineral_homeostasis	0.80108351
84	MP0001765_abnormal_ion_homeostasis	0.78540819
85	MP0002160_abnormal_reproductive_system	0.77557104
86	MP0003283_abnormal_digestive_organ	0.77417400
87	MP0003638_abnormal_response/metabolism_	0.73552964
88	MP0001119_abnormal_female_reproductive	0.71534155
89	MP0003252_abnormal_bile_duct	0.71244650
90	MP0001440_abnormal_grooming_behavior	0.70108903
91	MP0003137_abnormal_impulse_conducting	0.69964419
92	MP0005365_abnormal_bile_salt	0.67844390
93	MP0003656_abnormal_erythrocyte_physiolo	0.66644282
94	MP0005332_abnormal_amino_acid	0.66315736
95	MP0001905_abnormal_dopamine_level	0.65700035
96	MP0002933_joint_inflammation	0.64998511
97	MP0001663_abnormal_digestive_system	0.64911304
98	MP0005083_abnormal_biliary_tract	0.63282537
99	MP0006035_abnormal_mitochondrial_morpho	0.63270224
100	MP0002693_abnormal_pancreas_physiology	0.62936837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.25410402
2	Stomatitis (HP:0010280)	3.96444098
3	Congenital stationary night blindness (HP:0007642)	3.72105437
4	Increased IgM level (HP:0003496)	3.59723699
5	Renal cortical cysts (HP:0000803)	3.55947950
6	Abnormality of the renal cortex (HP:0011035)	3.43545242
7	Testicular atrophy (HP:0000029)	3.09356496
8	Abnormality of eosinophils (HP:0001879)	3.06667906
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.01553355
10	Conical tooth (HP:0000698)	3.00939574
11	Pancreatic cysts (HP:0001737)	2.96577652
12	Severe combined immunodeficiency (HP:0004430)	2.94291449
13	Decreased central vision (HP:0007663)	2.93818269
14	Mitochondrial inheritance (HP:0001427)	2.92338625
15	Increased CSF lactate (HP:0002490)	2.90194624
16	Aplastic anemia (HP:0001915)	2.84220232
17	Increased hepatocellular lipid droplets (HP:0006565)	2.81518359
18	Lipid accumulation in hepatocytes (HP:0006561)	2.78700221
19	IgM deficiency (HP:0002850)	2.78484905
20	Congenital, generalized hypertrichosis (HP:0004540)	2.77394502
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76965212
22	Abnormality of B cell number (HP:0010975)	2.75376949
23	3-Methylglutaconic aciduria (HP:0003535)	2.71715033
24	Methylmalonic acidemia (HP:0002912)	2.70992706
25	Abolished electroretinogram (ERG) (HP:0000550)	2.66849270
26	Stomach cancer (HP:0012126)	2.54134846
27	Nephronophthisis (HP:0000090)	2.51565167
28	Thyroiditis (HP:0100646)	2.51000489
29	Acute necrotizing encephalopathy (HP:0006965)	2.49951329
30	Type 2 muscle fiber atrophy (HP:0003554)	2.48847716
31	Hepatocellular necrosis (HP:0001404)	2.47783939
32	Hypoproteinemia (HP:0003075)	2.47104748
33	Hepatic necrosis (HP:0002605)	2.45433893
34	B lymphocytopenia (HP:0010976)	2.44370688
35	Abnormal drinking behavior (HP:0030082)	2.38135415
36	Polydipsia (HP:0001959)	2.38135415
37	Retrobulbar optic neuritis (HP:0100654)	2.36325528
38	Optic neuritis (HP:0100653)	2.36325528
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34877689
40	Acute encephalopathy (HP:0006846)	2.33741023
41	Oral leukoplakia (HP:0002745)	2.33667447
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31263108
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31263108
44	Abnormality of T cell number (HP:0011839)	2.30734219
45	Molar tooth sign on MRI (HP:0002419)	2.30369652
46	Abnormality of midbrain morphology (HP:0002418)	2.30369652
47	Abnormality of T cells (HP:0002843)	2.27802471
48	Increased intramyocellular lipid droplets (HP:0012240)	2.26355562
49	Pancreatic fibrosis (HP:0100732)	2.25630480
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24956098
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.24249480
52	Eosinophilia (HP:0001880)	2.22533831
53	Increased serum lactate (HP:0002151)	2.22168765
54	Abnormality of T cell physiology (HP:0011840)	2.21687288
55	Alveolar cell carcinoma (HP:0006519)	2.20846868
56	Abnormality of the renal medulla (HP:0100957)	2.20722707
57	Encephalitis (HP:0002383)	2.19965302
58	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.19275377
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.19122961
60	Progressive macrocephaly (HP:0004481)	2.18052463
61	Pancytopenia (HP:0001876)	2.18014974
62	Renal Fanconi syndrome (HP:0001994)	2.16492583
63	Attenuation of retinal blood vessels (HP:0007843)	2.16330762
64	Keratoconus (HP:0000563)	2.16229357
65	Increased corneal curvature (HP:0100692)	2.16229357
66	True hermaphroditism (HP:0010459)	2.15733942
67	Asplenia (HP:0001746)	2.15582883
68	Abnormal rod and cone electroretinograms (HP:0008323)	2.14904583
69	Myositis (HP:0100614)	2.14862320
70	Parakeratosis (HP:0001036)	2.14492300
71	Concave nail (HP:0001598)	2.13802036
72	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.13156115
73	Combined immunodeficiency (HP:0005387)	2.11125614
74	Muscle fiber atrophy (HP:0100295)	2.10507435
75	Cerebral hypomyelination (HP:0006808)	2.07144134
76	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.06476277
77	Hyperglycinemia (HP:0002154)	2.05793073
78	Decreased circulating renin level (HP:0003351)	2.04677857
79	Pendular nystagmus (HP:0012043)	2.02305087
80	T lymphocytopenia (HP:0005403)	1.99962500
81	Chronic hepatic failure (HP:0100626)	1.99317279
82	Increased muscle lipid content (HP:0009058)	1.98804098
83	Hypoplasia of the uterus (HP:0000013)	1.98591153
84	Exertional dyspnea (HP:0002875)	1.97823484
85	Methylmalonic aciduria (HP:0012120)	1.96156535
86	Hypochromic anemia (HP:0001931)	1.94975472
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.94296471
88	Abnormal number of erythroid precursors (HP:0012131)	1.93084692
89	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.92604852
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90464787
91	Absent/shortened dynein arms (HP:0200106)	1.89864286
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89864286
93	Dicarboxylic aciduria (HP:0003215)	1.89491233
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89491233
95	Generalized aminoaciduria (HP:0002909)	1.89259906
96	Polyuria (HP:0000103)	1.89059820
97	Premature ovarian failure (HP:0008209)	1.87826868
98	Abnormality of urine glucose concentration (HP:0011016)	1.85306927
99	Glycosuria (HP:0003076)	1.85306927
100	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.85233204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK1	3.65365096
2	TAOK3	3.43583558
3	TXK	3.39656783
4	TLK1	3.37162056
5	MAP4K1	3.20056683
6	ZAK	3.10155714
7	TESK2	3.05250013
8	MAP4K2	2.99529511
9	BMPR2	2.82539884
10	GRK1	2.63520875
11	KDR	2.48690555
12	STK16	2.22315720
13	ADRBK2	2.19284122
14	FRK	1.92411533
15	FES	1.64343437
16	MUSK	1.56371082
17	IKBKB	1.53477873
18	WNK4	1.47515033
19	CDK8	1.47322986
20	PRKCI	1.43730468
21	TIE1	1.33556151
22	KIT	1.28491183
23	PASK	1.26449264
24	SYK	1.21839941
25	NUAK1	1.21119657
26	BMPR1B	1.18243910
27	INSRR	1.15940789
28	VRK2	1.15938842
29	IKBKE	1.14908086
30	JAK3	1.14209768
31	LIMK1	1.12891517
32	NEK1	1.12583277
33	MAPKAPK3	1.12435172
34	CAMKK2	1.12218883
35	EIF2AK3	1.10993713
36	TNK2	1.10390745
37	ITK	1.04327821
38	LCK	1.02996050
39	TBK1	1.01442935
40	GRK6	1.01043754
41	BUB1	1.00835898
42	AKT3	0.98922178
43	BCKDK	0.98609808
44	TEC	0.97755940
45	BTK	0.96560598
46	MAP3K14	0.96069324
47	RIPK4	0.93198383
48	RPS6KA5	0.92354897
49	SRPK1	0.87745902
50	LYN	0.85920074
51	MAP2K2	0.84486045
52	CAMKK1	0.84141237
53	EIF2AK2	0.83671058
54	PRKCQ	0.82246600
55	PIK3CG	0.81317188
56	DAPK2	0.80566794
57	DAPK3	0.76132089
58	PRKCE	0.71901656
59	DAPK1	0.66389625
60	BRSK2	0.66300249
61	MST4	0.64885827
62	PIK3CA	0.63038485
63	VRK1	0.62101869
64	PRKCG	0.62029269
65	WNK3	0.61177721
66	PHKG1	0.61059823
67	PHKG2	0.61059823
68	PLK4	0.60091015
69	ADRBK1	0.58379493
70	CSNK1G3	0.57907498
71	MAP2K6	0.57902612
72	MATK	0.56849513
73	PRKCD	0.56184473
74	ZAP70	0.54685839
75	PTK2B	0.54299058
76	OBSCN	0.49386800
77	PINK1	0.49095320
78	CSK	0.48489484
79	HCK	0.48489415
80	BRSK1	0.45839951
81	MAPK13	0.45255037
82	OXSR1	0.44815432
83	PIM1	0.43916443
84	CDK19	0.42848069
85	MYLK	0.42624918
86	CSNK1A1L	0.42454293
87	GRK7	0.42142049
88	CSNK1A1	0.42090534
89	STK38L	0.38906913
90	STK39	0.38052320
91	CSNK2A1	0.35977796
92	CSNK2A2	0.35640057
93	ATR	0.35120921
94	NME1	0.35016162
95	GRK5	0.34216345
96	PRKACA	0.34178316
97	MAP3K12	0.33916991
98	PRKCA	0.33875341
99	IGF1R	0.31541672
100	CSNK1G2	0.29170491

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.72810401
2	Ribosome_Homo sapiens_hsa03010	3.09074828
3	Allograft rejection_Homo sapiens_hsa05330	3.07337502
4	Asthma_Homo sapiens_hsa05310	2.97070213
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.96494156
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.93837663
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90615469
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.77415183
9	Phototransduction_Homo sapiens_hsa04744	2.50060058
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.48099571
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.42333385
12	Proteasome_Homo sapiens_hsa03050	2.34866993
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06252138
14	Sulfur relay system_Homo sapiens_hsa04122	2.00286900
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97125918
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.94107485
17	One carbon pool by folate_Homo sapiens_hsa00670	1.84216920
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78875189
19	Parkinsons disease_Homo sapiens_hsa05012	1.71307608
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.70874656
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.65370495
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60799382
23	RNA polymerase_Homo sapiens_hsa03020	1.55512765
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.51075146
25	Protein export_Homo sapiens_hsa03060	1.43007100
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32852477
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.32428014
28	RNA degradation_Homo sapiens_hsa03018	1.32324143
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.31988207
30	Homologous recombination_Homo sapiens_hsa03440	1.30452708
31	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.28548154
32	Tyrosine metabolism_Homo sapiens_hsa00350	1.24348002
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22471340
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17848671
35	Olfactory transduction_Homo sapiens_hsa04740	1.14564886
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.10492355
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.06973977
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.05979100
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05376184
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04162991
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99937248
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99055210
43	Huntingtons disease_Homo sapiens_hsa05016	0.94993353
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94369527
45	Alzheimers disease_Homo sapiens_hsa05010	0.94081746
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.93898262
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90935047
48	Viral myocarditis_Homo sapiens_hsa05416	0.88181122
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88040708
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.83181508
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.80503091
52	Peroxisome_Homo sapiens_hsa04146	0.80290426
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78441683
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78256861
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.75722336
56	Retinol metabolism_Homo sapiens_hsa00830	0.74707129
57	Regulation of autophagy_Homo sapiens_hsa04140	0.74648293
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73298464
59	Folate biosynthesis_Homo sapiens_hsa00790	0.73093557
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.72576462
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71860397
62	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.70768184
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70452300
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70410848
65	Purine metabolism_Homo sapiens_hsa00230	0.67615842
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67349341
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67279808
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66694095
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64424538
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64321548
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62310640
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59008842
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.55495041
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54846811
75	Measles_Homo sapiens_hsa05162	0.52698430
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52336036
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.52073616
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51224099
79	Herpes simplex infection_Homo sapiens_hsa05168	0.51049511
80	Leishmaniasis_Homo sapiens_hsa05140	0.46523031
81	Propanoate metabolism_Homo sapiens_hsa00640	0.45889582
82	Basal transcription factors_Homo sapiens_hsa03022	0.45552338
83	Mineral absorption_Homo sapiens_hsa04978	0.45304290
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44169829
85	RNA transport_Homo sapiens_hsa03013	0.43560264
86	Butanoate metabolism_Homo sapiens_hsa00650	0.43451953
87	Malaria_Homo sapiens_hsa05144	0.42561300
88	Metabolic pathways_Homo sapiens_hsa01100	0.41569539
89	Glutathione metabolism_Homo sapiens_hsa00480	0.41260434
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40589483
91	Base excision repair_Homo sapiens_hsa03410	0.38824323
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38474262
93	Legionellosis_Homo sapiens_hsa05134	0.35032088
94	Sulfur metabolism_Homo sapiens_hsa00920	0.32816384
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32768009
96	Taste transduction_Homo sapiens_hsa04742	0.25469772
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23780941
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.21890411
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.19474966
100	Spliceosome_Homo sapiens_hsa03040	0.18501894

RPL23AP38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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