ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	9.70253609
2	meiosis I (GO:0007127)	9.55351643
3	DNA synthesis involved in DNA repair (GO:0000731)	9.10531431
4	cell wall macromolecule catabolic process (GO:0016998)	8.96566424
5	male meiosis (GO:0007140)	8.38995070
6	maturation of SSU-rRNA (GO:0030490)	8.29738004
7	meiotic nuclear division (GO:0007126)	7.72903858
8	cell wall macromolecule metabolic process (GO:0044036)	7.40916791
9	DNA methylation involved in gamete generation (GO:0043046)	7.24727598
10	meiotic chromosome segregation (GO:0045132)	7.17353084
11	resolution of meiotic recombination intermediates (GO:0000712)	6.87898044
12	meiotic cell cycle process (GO:1903046)	6.85817634
13	regulation of meiosis I (GO:0060631)	6.24636585
14	ribosomal small subunit biogenesis (GO:0042274)	5.60923474
15	reciprocal meiotic recombination (GO:0007131)	5.53480631
16	reciprocal DNA recombination (GO:0035825)	5.53480631
17	sister chromatid cohesion (GO:0007062)	5.19811061
18	viral protein processing (GO:0019082)	4.60869576
19	histone H3-K9 demethylation (GO:0033169)	4.60624137
20	negative regulation of appetite (GO:0032099)	4.48171677
21	negative regulation of response to food (GO:0032096)	4.48171677
22	positive regulation of response to oxidative stress (GO:1902884)	4.31871481
23	positive regulation of cellular response to oxidative stress (GO:1900409)	4.31871481
24	proteasome assembly (GO:0043248)	4.17537336
25	female gamete generation (GO:0007292)	4.10307728
26	acrosome assembly (GO:0001675)	3.97809600
27	histone exchange (GO:0043486)	3.78874462
28	regulation of histone H3-K9 methylation (GO:0051570)	3.73134689
29	gene silencing by RNA (GO:0031047)	3.70479698
30	protein neddylation (GO:0045116)	3.70169083
31	regulation of cilium movement (GO:0003352)	3.64977722
32	chromatin remodeling at centromere (GO:0031055)	3.58538331
33	CENP-A containing nucleosome assembly (GO:0034080)	3.57574708
34	regulation of microtubule-based movement (GO:0060632)	3.42045154
35	positive regulation of meiosis (GO:0045836)	3.34704530
36	negative regulation of gene silencing (GO:0060969)	3.31122914
37	replication fork processing (GO:0031297)	3.30088157
38	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.29675721
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.28547404
40	regulation of response to food (GO:0032095)	3.26337875
41	reproductive system development (GO:0061458)	3.24613123
42	intraciliary transport (GO:0042073)	3.21188619
43	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.16782983
44	DNA replication checkpoint (GO:0000076)	3.14674578
45	histone H3-K36 demethylation (GO:0070544)	3.14196037
46	ribosomal small subunit assembly (GO:0000028)	3.13163808
47	spermatid development (GO:0007286)	3.09195936
48	positive regulation of meiotic cell cycle (GO:0051446)	3.07830419
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.06438700
50	regulation of meiotic cell cycle (GO:0051445)	3.06029496
51	centriole replication (GO:0007099)	3.05811258
52	kinetochore organization (GO:0051383)	3.04405956
53	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.02149563
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.01541486
55	chromosome organization (GO:0051276)	2.94205496
56	pyrimidine nucleotide catabolic process (GO:0006244)	2.93811270
57	virion assembly (GO:0019068)	2.92467483
58	myeloid cell homeostasis (GO:0002262)	2.90241304
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.83002030
60	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.81300130
61	mitotic chromosome condensation (GO:0007076)	2.81236375
62	meiotic cell cycle (GO:0051321)	2.80772168
63	poly(A)+ mRNA export from nucleus (GO:0016973)	2.80645232
64	DNA biosynthetic process (GO:0071897)	2.78429404
65	microtubule severing (GO:0051013)	2.75908897
66	nuclear division (GO:0000280)	2.72336409
67	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.70508083
68	mismatch repair (GO:0006298)	2.69696122
69	nonmotile primary cilium assembly (GO:0035058)	2.67943972
70	DNA methylation (GO:0006306)	2.67757513
71	DNA alkylation (GO:0006305)	2.67757513
72	embryonic body morphogenesis (GO:0010172)	2.64598389
73	chaperone-mediated protein complex assembly (GO:0051131)	2.64468339
74	DNA replication-independent nucleosome organization (GO:0034724)	2.64175370
75	DNA replication-independent nucleosome assembly (GO:0006336)	2.64175370
76	regulation of centriole replication (GO:0046599)	2.60048043
77	substrate-independent telencephalic tangential migration (GO:0021826)	2.58258643
78	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.58258643
79	regulation of DNA endoreduplication (GO:0032875)	2.55270442
80	protein localization to chromosome (GO:0034502)	2.54609402
81	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53238651
82	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53238651
83	NADH dehydrogenase complex assembly (GO:0010257)	2.53238651
84	attachment of spindle microtubules to kinetochore (GO:0008608)	2.50824501
85	DNA ligation (GO:0006266)	2.49580401
86	organelle fission (GO:0048285)	2.49382078
87	binding of sperm to zona pellucida (GO:0007339)	2.49276759
88	left/right pattern formation (GO:0060972)	2.49031115
89	regulation of female receptivity (GO:0045924)	2.45602252
90	ovulation cycle (GO:0042698)	2.44403011
91	female mating behavior (GO:0060180)	2.43485135
92	rRNA catabolic process (GO:0016075)	2.40370488
93	fertilization (GO:0009566)	2.38531445
94	oogenesis (GO:0048477)	2.36517209
95	nucleotide transmembrane transport (GO:1901679)	2.33893739
96	synapsis (GO:0007129)	12.9100389
97	chromosome organization involved in meiosis (GO:0070192)	12.0799202
98	male meiosis I (GO:0007141)	11.5025570
99	synaptonemal complex assembly (GO:0007130)	11.3277406
100	synaptonemal complex organization (GO:0070193)	10.3333013

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.24147119
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.07361050
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.03589942
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.28559611
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23090612
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.93328323
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.78122129
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.75345115
9	RNF2_27304074_Chip-Seq_NSC_Mouse	2.73355104
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65712333
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53236451
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.48481091
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30168201
14	FUS_26573619_Chip-Seq_HEK293_Human	2.29070332
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.27426286
16	VDR_22108803_ChIP-Seq_LS180_Human	2.26767294
17	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.25230129
18	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.15520051
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.07898013
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01048639
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.98797120
22	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.93063033
23	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.88819298
24	E2F7_22180533_ChIP-Seq_HELA_Human	1.86675993
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.83196402
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82583940
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.82267089
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.79963172
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76974585
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.75943038
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70913646
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.69802247
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63614732
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.58911317
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.55492414
36	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.50103565
37	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.49370092
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.48441526
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46580374
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43926531
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41770313
42	ZNF274_21170338_ChIP-Seq_K562_Hela	1.36822202
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.35384354
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34078827
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.33948739
46	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.33758544
47	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.33567775
48	EWS_26573619_Chip-Seq_HEK293_Human	1.32603938
49	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.31594258
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.30016265
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.28119045
52	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.27502752
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26227687
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.25322715
55	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.25071143
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.23005094
57	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22278399
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.20550388
59	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.20323366
60	ERA_21632823_ChIP-Seq_H3396_Human	1.15696608
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.14919242
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.13467561
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12752284
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12752284
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09026467
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07020733
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06321333
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05476970
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.03829339
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03497996
71	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02443321
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02375115
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02212138
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01747027
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01493675
76	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01477685
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00970902
78	GATA3_26560356_Chip-Seq_TH1_Human	1.00426280
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99369393
80	AR_20517297_ChIP-Seq_VCAP_Human	0.98745388
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98665672
82	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98055351
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96315232
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96315232
85	BCAT_22108803_ChIP-Seq_LS180_Human	0.95753049
86	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.95637499
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.95560302
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95143795
89	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93982495
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92521942
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91293902
92	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91240292
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87982623
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87982623
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87911372
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.87891162
97	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.87834817
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.87564947
99	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.87543006
100	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.87210828

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	6.53913807
2	MP0009379_abnormal_foot_pigmentation	5.92631446
3	MP0002210_abnormal_sex_determination	3.86597779
4	MP0008789_abnormal_olfactory_epithelium	3.59926906
5	MP0008058_abnormal_DNA_repair	3.52873021
6	MP0002160_abnormal_reproductive_system	3.43663436
7	MP0001929_abnormal_gametogenesis	3.21558225
8	MP0005394_taste/olfaction_phenotype	2.91639010
9	MP0005499_abnormal_olfactory_system	2.91639010
10	MP0001145_abnormal_male_reproductive	2.76191390
11	MP0003698_abnormal_male_reproductive	2.76142594
12	MP0006292_abnormal_olfactory_placode	2.60297100
13	MP0000653_abnormal_sex_gland	2.53001335
14	MP0008004_abnormal_stomach_pH	2.43885588
15	MP0000678_abnormal_parathyroid_gland	2.34918080
16	MP0005464_abnormal_platelet_physiology	2.32708346
17	MP0003693_abnormal_embryo_hatching	2.19119684
18	MP0002653_abnormal_ependyma_morphology	2.08596285
19	MP0005389_reproductive_system_phenotype	2.03618189
20	MP0005174_abnormal_tail_pigmentation	1.98603189
21	MP0005410_abnormal_fertilization	1.90182585
22	MP0001119_abnormal_female_reproductive	1.78743327
23	MP0001485_abnormal_pinna_reflex	1.76917501
24	MP0002234_abnormal_pharynx_morphology	1.68935407
25	MP0003718_maternal_effect	1.66242884
26	MP0002161_abnormal_fertility/fecundity	1.62936980
27	MP0001984_abnormal_olfaction	1.60501909
28	MP0008995_early_reproductive_senescence	1.56003459
29	MP0003111_abnormal_nucleus_morphology	1.55608779
30	MP0010094_abnormal_chromosome_stability	1.55510709
31	MP0008007_abnormal_cellular_replicative	1.55396376
32	MP0005171_absent_coat_pigmentation	1.46556445
33	MP0004142_abnormal_muscle_tone	1.42046159
34	MP0003699_abnormal_female_reproductive	1.36882611
35	MP0002638_abnormal_pupillary_reflex	1.35281689
36	MP0003950_abnormal_plasma_membrane	1.27704215
37	MP0003937_abnormal_limbs/digits/tail_de	1.24824676
38	MP0008932_abnormal_embryonic_tissue	1.20082420
39	MP0004134_abnormal_chest_morphology	1.18070765
40	MP0003077_abnormal_cell_cycle	1.14766042
41	MP0001293_anophthalmia	1.13224774
42	MP0003186_abnormal_redox_activity	1.09883052
43	MP0002095_abnormal_skin_pigmentation	1.08935551
44	MP0004957_abnormal_blastocyst_morpholog	1.08543943
45	MP0000778_abnormal_nervous_system	1.07137365
46	MP0006035_abnormal_mitochondrial_morpho	1.04475268
47	MP0000015_abnormal_ear_pigmentation	1.04347385
48	MP0002233_abnormal_nose_morphology	1.00023909
49	MP0001324_abnormal_eye_pigmentation	0.99954138
50	MP0006036_abnormal_mitochondrial_physio	0.97793699
51	MP0009053_abnormal_anal_canal	0.96163490
52	MP0001529_abnormal_vocalization	0.94927057
53	MP0002736_abnormal_nociception_after	0.92171280
54	MP0003119_abnormal_digestive_system	0.91172858
55	MP0006276_abnormal_autonomic_nervous	0.90831961
56	MP0003786_premature_aging	0.88979115
57	MP0002132_abnormal_respiratory_system	0.86910317
58	MP0005083_abnormal_biliary_tract	0.81761569
59	MP0000955_abnormal_spinal_cord	0.79712023
60	MP0004019_abnormal_vitamin_homeostasis	0.78962808
61	MP0000427_abnormal_hair_cycle	0.78894527
62	MP0004215_abnormal_myocardial_fiber	0.76635890
63	MP0003646_muscle_fatigue	0.74667639
64	MP0002084_abnormal_developmental_patter	0.74315862
65	MP0002163_abnormal_gland_morphology	0.72520901
66	MP0001697_abnormal_embryo_size	0.72223015
67	MP0010030_abnormal_orbit_morphology	0.71872322
68	MP0003890_abnormal_embryonic-extraembry	0.71109130
69	MP0003879_abnormal_hair_cell	0.69717316
70	MP0000631_abnormal_neuroendocrine_gland	0.68049574
71	MP0003861_abnormal_nervous_system	0.66680844
72	MP0000049_abnormal_middle_ear	0.66143368
73	MP0002085_abnormal_embryonic_tissue	0.65843503
74	MP0000358_abnormal_cell_content/	0.64837086
75	MP0009703_decreased_birth_body	0.64538616
76	MP0000313_abnormal_cell_death	0.62598507
77	MP0009046_muscle_twitch	0.61974196
78	MP0001730_embryonic_growth_arrest	0.61275293
79	MP0003123_paternal_imprinting	0.61002612
80	MP0005058_abnormal_lysosome_morphology	0.60613557
81	MP0000569_abnormal_digit_pigmentation	0.60576600
82	MP0008775_abnormal_heart_ventricle	0.59625947
83	MP0005646_abnormal_pituitary_gland	0.59264742
84	MP0000383_abnormal_hair_follicle	0.58484301
85	MP0003936_abnormal_reproductive_system	0.57953884
86	MP0002090_abnormal_vision	0.56961954
87	MP0000230_abnormal_systemic_arterial	0.56000681
88	MP0000026_abnormal_inner_ear	0.53742901
89	MP0001486_abnormal_startle_reflex	0.51136237
90	MP0009250_abnormal_appendicular_skeleto	0.50896722
91	MP0003755_abnormal_palate_morphology	0.50876088
92	MP0001915_intracranial_hemorrhage	0.50192640
93	MP0001542_abnormal_bone_strength	0.49682609
94	MP0005023_abnormal_wound_healing	0.49316832
95	MP0004147_increased_porphyrin_level	0.49047402
96	MP0001968_abnormal_touch/_nociception	0.48579941
97	MP0000647_abnormal_sebaceous_gland	0.48434762
98	MP0001879_abnormal_lymphatic_vessel	0.48353759
99	MP0001963_abnormal_hearing_physiology	0.48214623
100	MP0002152_abnormal_brain_morphology	0.48196016

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	7.83856313
2	Partial duplication of thumb phalanx (HP:0009944)	5.20913704
3	Rectal fistula (HP:0100590)	4.61860504
4	Rectovaginal fistula (HP:0000143)	4.61860504
5	Partial duplication of the phalanx of hand (HP:0009999)	4.54317083
6	Spontaneous abortion (HP:0005268)	4.45592742
7	11 pairs of ribs (HP:0000878)	4.42840381
8	Abnormality of the phalanges of the hallux (HP:0010057)	4.18577083
9	Medial flaring of the eyebrow (HP:0010747)	4.11002183
10	Molar tooth sign on MRI (HP:0002419)	4.00523377
11	Abnormality of midbrain morphology (HP:0002418)	4.00523377
12	Vaginal fistula (HP:0004320)	3.88367278
13	Intestinal fistula (HP:0100819)	3.75720280
14	Duplication of thumb phalanx (HP:0009942)	3.67544982
15	Abnormal hemoglobin (HP:0011902)	3.62314845
16	Nephrogenic diabetes insipidus (HP:0009806)	3.61166715
17	Congenital primary aphakia (HP:0007707)	3.53755886
18	Gait imbalance (HP:0002141)	3.42465536
19	Microretrognathia (HP:0000308)	3.34529420
20	Azoospermia (HP:0000027)	3.33485002
21	Poor coordination (HP:0002370)	3.25193874
22	Shoulder girdle muscle weakness (HP:0003547)	3.06748011
23	Impulsivity (HP:0100710)	2.99655565
24	Abnormal spermatogenesis (HP:0008669)	2.77448675
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.75268083
26	Abnormality of alanine metabolism (HP:0010916)	2.75268083
27	Hyperalaninemia (HP:0003348)	2.75268083
28	Hyperlipoproteinemia (HP:0010980)	2.70206372
29	Prolonged bleeding time (HP:0003010)	2.56655798
30	Progressive external ophthalmoplegia (HP:0000590)	2.55790191
31	Pallor (HP:0000980)	2.54523181
32	Oligodactyly (hands) (HP:0001180)	2.46132998
33	Macrocytic anemia (HP:0001972)	2.45099617
34	Broad foot (HP:0001769)	2.43342191
35	Hyperglycinemia (HP:0002154)	2.42330913
36	Genital tract atresia (HP:0001827)	2.42308325
37	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.41312879
38	Bifid tongue (HP:0010297)	2.38426283
39	Vaginal atresia (HP:0000148)	2.38203938
40	Abnormality of the lower motor neuron (HP:0002366)	2.32714623
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.32266748
42	Absent/shortened dynein arms (HP:0200106)	2.32266748
43	Absent thumb (HP:0009777)	2.32094451
44	Hypoplasia of the radius (HP:0002984)	2.29429397
45	Chromsome breakage (HP:0040012)	2.25880877
46	Amyotrophic lateral sclerosis (HP:0007354)	2.25183896
47	Acute necrotizing encephalopathy (HP:0006965)	2.24194788
48	Rimmed vacuoles (HP:0003805)	2.13698903
49	Type I transferrin isoform profile (HP:0003642)	2.13044208
50	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12711565
51	Oculomotor apraxia (HP:0000657)	2.11557882
52	Colon cancer (HP:0003003)	2.11392092
53	Increased mean platelet volume (HP:0011877)	2.11051044
54	Postaxial foot polydactyly (HP:0001830)	2.10542221
55	Thrombocytosis (HP:0001894)	2.10099170
56	Abnormal tarsal ossification (HP:0008369)	2.10015161
57	Acute encephalopathy (HP:0006846)	2.08560550
58	Abnormality of reticulocytes (HP:0004312)	2.08328925
59	Nephronophthisis (HP:0000090)	2.06610358
60	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.05466421
61	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.05466421
62	Preaxial hand polydactyly (HP:0001177)	2.04887618
63	Hypoplastic iliac wings (HP:0002866)	2.04424813
64	Non-midline cleft lip (HP:0100335)	2.03166129
65	Abnormal protein glycosylation (HP:0012346)	1.99172031
66	Abnormal glycosylation (HP:0012345)	1.99172031
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99172031
68	Abnormal protein N-linked glycosylation (HP:0012347)	1.99172031
69	Anencephaly (HP:0002323)	1.97120914
70	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.96862353
71	Abnormality of cochlea (HP:0000375)	1.96105010
72	Increased nuchal translucency (HP:0010880)	1.92314613
73	Gonadotropin excess (HP:0000837)	1.91387532
74	Missing ribs (HP:0000921)	1.88774917
75	Facial hemangioma (HP:0000329)	1.88317043
76	Petechiae (HP:0000967)	1.85545671
77	Depressed nasal ridge (HP:0000457)	1.84738770
78	Abnormal mitochondria in muscle tissue (HP:0008316)	1.83781818
79	Acanthocytosis (HP:0001927)	1.83554770
80	Menorrhagia (HP:0000132)	1.82219524
81	Tracheal stenosis (HP:0002777)	1.81878257
82	Ectopic kidney (HP:0000086)	1.81869281
83	Abnormal platelet volume (HP:0011876)	1.81654472
84	Abnormality of the corticospinal tract (HP:0002492)	1.79125752
85	Wrist flexion contracture (HP:0001239)	1.78661091
86	Supernumerary spleens (HP:0009799)	1.78126013
87	Horizontal nystagmus (HP:0000666)	1.77701923
88	Male infertility (HP:0003251)	1.77084754
89	Abnormality of DNA repair (HP:0003254)	1.75079692
90	Aplasia/Hypoplasia of the lens (HP:0008063)	1.74859766
91	Aganglionic megacolon (HP:0002251)	1.74084643
92	Abnormality of the labia minora (HP:0012880)	1.73522835
93	Progressive macrocephaly (HP:0004481)	1.72661083
94	Pancreatic fibrosis (HP:0100732)	1.72226966
95	Postaxial hand polydactyly (HP:0001162)	1.70819646
96	Oligodactyly (HP:0012165)	1.68913099
97	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.68865097
98	Mitral stenosis (HP:0001718)	1.67268198
99	Multicystic kidney dysplasia (HP:0000003)	1.65129177
100	Infertility (HP:0000789)	1.64858539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	7.82008474
2	CDK19	4.70286199
3	TRIM28	3.77908786
4	PDK2	3.30487133
5	BMX	2.90723993
6	CAMK1G	2.62638339
7	MET	2.57671397
8	PTK2B	2.53307973
9	FGR	2.49827078
10	CDC7	2.45351172
11	PLK2	2.29570211
12	TYRO3	2.08479972
13	ZAK	2.01693735
14	IRAK2	1.87216266
15	EIF2AK1	1.80734386
16	TTK	1.67655143
17	PLK4	1.59017953
18	NEK1	1.53652795
19	CSF1R	1.52480887
20	MAP3K4	1.50521300
21	PRKCI	1.45788379
22	STK16	1.45659772
23	PLK1	1.39653367
24	OXSR1	1.38642799
25	STK3	1.21816630
26	LIMK1	1.17805667
27	CAMK1	1.04653800
28	ADRBK2	1.04215122
29	RET	1.01586969
30	BRAF	0.98461192
31	NUAK1	0.95749712
32	MKNK2	0.95294391
33	AURKA	0.93620254
34	VRK1	0.92536866
35	PLK3	0.88102292
36	MST4	0.83992476
37	PRKCG	0.83330686
38	NEK9	0.81126577
39	IRAK1	0.77770762
40	CHEK2	0.77131816
41	MARK3	0.76571433
42	DYRK3	0.74869110
43	MAP3K5	0.73084524
44	CHEK1	0.71279417
45	STK24	0.70799438
46	TEC	0.68924581
47	EPHB2	0.67021630
48	MYLK	0.66615967
49	PIK3CA	0.65624730
50	WEE1	0.64029268
51	DYRK1A	0.58797319
52	MINK1	0.57915925
53	CDK11A	0.56618623
54	BTK	0.55214197
55	PDGFRB	0.55171202
56	CDK3	0.54665013
57	CSNK1E	0.54452499
58	PTK2	0.53387760
59	CSNK2A2	0.51266120
60	ATR	0.50541638
61	ATM	0.50409165
62	DMPK	0.49498394
63	ARAF	0.48519638
64	CDK14	0.48506526
65	MAPK13	0.46993876
66	TSSK6	0.44371024
67	PDPK1	0.41165333
68	PAK1	0.40735499
69	PRKCZ	0.40105641
70	CDK2	0.38319035
71	EGFR	0.37395832
72	LRRK2	0.37251548
73	PKN1	0.36714923
74	NTRK3	0.36629704
75	MKNK1	0.32809029
76	ILK	0.32533567
77	PRKG1	0.32523633
78	NEK2	0.31661125
79	IGF1R	0.31230539
80	MAP4K2	0.31125584
81	CDK15	0.30836442
82	BCR	0.30614642
83	CDK18	0.29503515
84	AURKB	0.29314712
85	INSRR	0.28736580
86	RPS6KA4	0.28489596
87	PINK1	0.28271470
88	BMPR1B	0.27192578
89	DAPK3	0.26826342
90	ADRBK1	0.25889130
91	PRKACB	0.25843231
92	TAOK3	0.25572433
93	INSR	0.25173379
94	CSNK2A1	0.25109612
95	SGK1	0.23860540
96	MAP3K2	0.23378526
97	GRK1	0.22988858
98	CDK1	0.22387579
99	CASK	0.22285301
100	PIM1	0.21801071

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	4.16179465
2	Homologous recombination_Homo sapiens_hsa03440	3.95596014
3	Ribosome_Homo sapiens_hsa03010	3.23467560
4	DNA replication_Homo sapiens_hsa03030	3.16718391
5	RNA degradation_Homo sapiens_hsa03018	3.09664241
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.99352979
7	Parkinsons disease_Homo sapiens_hsa05012	2.91456502
8	RNA transport_Homo sapiens_hsa03013	2.52986924
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52386930
10	Cell cycle_Homo sapiens_hsa04110	2.47319414
11	Huntingtons disease_Homo sapiens_hsa05016	2.39765319
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.31815149
13	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.21005094
14	Oocyte meiosis_Homo sapiens_hsa04114	2.18040158
15	Basal transcription factors_Homo sapiens_hsa03022	2.16791543
16	Spliceosome_Homo sapiens_hsa03040	2.07211171
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.93698877
18	Fatty acid elongation_Homo sapiens_hsa00062	1.89008998
19	Proteasome_Homo sapiens_hsa03050	1.85470133
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.74957528
21	Protein export_Homo sapiens_hsa03060	1.74531570
22	p53 signaling pathway_Homo sapiens_hsa04115	1.73351012
23	Sulfur relay system_Homo sapiens_hsa04122	1.55581583
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53340367
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.46634900
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.46596048
27	Base excision repair_Homo sapiens_hsa03410	1.41464849
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.38361525
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36341546
30	Regulation of autophagy_Homo sapiens_hsa04140	1.35749683
31	Propanoate metabolism_Homo sapiens_hsa00640	1.25353477
32	One carbon pool by folate_Homo sapiens_hsa00670	1.24038670
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22876228
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22316100
35	Alzheimers disease_Homo sapiens_hsa05010	1.20220709
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19638031
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14490547
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.11350877
39	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04391591
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03540762
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03458704
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.92840174
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.92639539
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91134391
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.87293535
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86224098
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85904066
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.85423211
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84444404
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84359973
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79950052
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73507433
53	Purine metabolism_Homo sapiens_hsa00230	0.72936721
54	Platelet activation_Homo sapiens_hsa04611	0.71133309
55	Olfactory transduction_Homo sapiens_hsa04740	0.66475831
56	Retinol metabolism_Homo sapiens_hsa00830	0.65035498
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64367167
58	Butanoate metabolism_Homo sapiens_hsa00650	0.64125686
59	RNA polymerase_Homo sapiens_hsa03020	0.57513857
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.56152441
61	Metabolic pathways_Homo sapiens_hsa01100	0.48963537
62	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.47940512
63	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.43722686
64	Choline metabolism in cancer_Homo sapiens_hsa05231	0.43714444
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41283713
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.40540248
67	Endocytosis_Homo sapiens_hsa04144	0.40397699
68	ECM-receptor interaction_Homo sapiens_hsa04512	0.40233588
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.35219704
70	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33793753
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32481175
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.31106496
73	mTOR signaling pathway_Homo sapiens_hsa04150	0.29840515
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29160544
75	Peroxisome_Homo sapiens_hsa04146	0.28847013
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28504553
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28281487
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27748173
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26589363
80	Gap junction_Homo sapiens_hsa04540	0.25143789
81	Small cell lung cancer_Homo sapiens_hsa05222	0.25045484
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23165708
83	Glutathione metabolism_Homo sapiens_hsa00480	0.23120501
84	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.22083446
85	Phototransduction_Homo sapiens_hsa04744	0.20519511
86	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.20411633
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19696717
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.19229698
89	Sulfur metabolism_Homo sapiens_hsa00920	0.18573965
90	Notch signaling pathway_Homo sapiens_hsa04330	0.17857035
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.17662209
92	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.14954143
93	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.14360928
94	Nicotine addiction_Homo sapiens_hsa05033	0.13697316
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.13030437
96	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.12460816
97	Taste transduction_Homo sapiens_hsa04742	0.11937995
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.11742927
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.10101521
100	Serotonergic synapse_Homo sapiens_hsa04726	0.09520737

RPL23AP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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