ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.41999012
2	viral transcription (GO:0019083)	5.96306183
3	ATP synthesis coupled proton transport (GO:0015986)	5.91862105
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.91862105
5	translational termination (GO:0006415)	5.70450256
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.28879863
7	translational elongation (GO:0006414)	4.92958435
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.88261067
9	protein targeting to ER (GO:0045047)	4.85456343
10	ribosomal small subunit biogenesis (GO:0042274)	4.80161245
11	cotranslational protein targeting to membrane (GO:0006613)	4.77290948
12	protein localization to endoplasmic reticulum (GO:0070972)	4.66451679
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.62701069
14	cellular protein complex disassembly (GO:0043624)	4.32610116
15	viral life cycle (GO:0019058)	4.30877863
16	maturation of SSU-rRNA (GO:0030490)	4.22751153
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.97167425
18	translational initiation (GO:0006413)	3.85556431
19	DNA deamination (GO:0045006)	3.85484384
20	electron transport chain (GO:0022900)	3.79295634
21	respiratory electron transport chain (GO:0022904)	3.78137000
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.63991786
23	ribosomal large subunit biogenesis (GO:0042273)	3.59426986
24	protein complex disassembly (GO:0043241)	3.56860294
25	negative regulation of telomere maintenance (GO:0032205)	3.48025295
26	macromolecular complex disassembly (GO:0032984)	3.45300600
27	behavioral response to nicotine (GO:0035095)	3.42012196
28	translation (GO:0006412)	3.40084945
29	protein neddylation (GO:0045116)	3.39380388
30	termination of RNA polymerase III transcription (GO:0006386)	3.32754077
31	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.32754077
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.28785984
33	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.25693089
34	GTP biosynthetic process (GO:0006183)	3.22192097
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.20778774
36	ATP biosynthetic process (GO:0006754)	3.20332462
37	mannosylation (GO:0097502)	3.17611269
38	hydrogen ion transmembrane transport (GO:1902600)	3.16430270
39	protein targeting to membrane (GO:0006612)	3.16321017
40	aldehyde catabolic process (GO:0046185)	3.08998350
41	sulfation (GO:0051923)	3.05078259
42	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.98722708
43	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.95272797
44	proton transport (GO:0015992)	2.94437711
45	pyrimidine nucleotide catabolic process (GO:0006244)	2.93841483
46	regulation of cellular amino acid metabolic process (GO:0006521)	2.93087073
47	hydrogen transport (GO:0006818)	2.87267239
48	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.85817692
49	adaptation of signaling pathway (GO:0023058)	2.82940905
50	sleep (GO:0030431)	2.80390879
51	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.79681454
52	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.75255336
53	ribonucleoprotein complex biogenesis (GO:0022613)	2.74847132
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73580901
55	regulation of response to tumor cell (GO:0002834)	2.73262560
56	positive regulation of response to tumor cell (GO:0002836)	2.73262560
57	positive regulation of immune response to tumor cell (GO:0002839)	2.73262560
58	regulation of immune response to tumor cell (GO:0002837)	2.73262560
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.72465224
60	protein complex biogenesis (GO:0070271)	2.72213893
61	base-excision repair, AP site formation (GO:0006285)	2.69741934
62	regulation of cilium movement (GO:0003352)	2.69640077
63	interferon-gamma production (GO:0032609)	2.67670527
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66827465
65	rRNA catabolic process (GO:0016075)	2.65754475
66	peptidyl-threonine dephosphorylation (GO:0035970)	2.65645423
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.65540732
68	mRNA catabolic process (GO:0006402)	2.62815301
69	regulation of T cell mediated cytotoxicity (GO:0001914)	2.61122017
70	pseudouridine synthesis (GO:0001522)	2.60517110
71	rRNA metabolic process (GO:0016072)	2.60097162
72	positive thymic T cell selection (GO:0045059)	2.59518126
73	mast cell activation (GO:0045576)	2.59490030
74	axoneme assembly (GO:0035082)	2.59295057
75	UTP biosynthetic process (GO:0006228)	2.59015653
76	positive regulation of defense response to virus by host (GO:0002230)	2.58675336
77	cellular component biogenesis (GO:0044085)	2.58286368
78	dopamine transport (GO:0015872)	2.56988334
79	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.56781851
80	GPI anchor metabolic process (GO:0006505)	2.55727197
81	spliceosomal complex assembly (GO:0000245)	2.54383855
82	negative regulation of mast cell activation (GO:0033004)	2.53838846
83	peptidyl-histidine modification (GO:0018202)	2.53112754
84	rRNA processing (GO:0006364)	2.52976562
85	amine biosynthetic process (GO:0009309)	2.51157498
86	regulation of chronic inflammatory response (GO:0002676)	2.49670890
87	proteasome assembly (GO:0043248)	2.47918585
88	cellular response to interleukin-15 (GO:0071350)	2.47525993
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.47413664
90	NADH dehydrogenase complex assembly (GO:0010257)	2.47413664
91	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.47413664
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.45140551
93	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.44269802
94	positive T cell selection (GO:0043368)	2.43906083
95	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.43852349
96	GPI anchor biosynthetic process (GO:0006506)	2.43591815
97	regulation of action potential (GO:0098900)	2.42500024
98	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.41933434
99	chaperone-mediated protein transport (GO:0072321)	2.41867700
100	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.41812028

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.44496711
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.38948132
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67259578
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00754304
5	VDR_22108803_ChIP-Seq_LS180_Human	2.90932760
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.88490300
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.74993344
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.71407500
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67699870
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59165352
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30600911
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.29495746
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.25295045
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.23531382
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.20036763
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85661759
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80490896
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78834904
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72720784
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68650370
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.66349880
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58046530
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58013202
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.57922126
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57256372
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56073782
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54885652
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.53856378
29	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.46189997
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46189355
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44604221
32	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.39009371
33	GATA3_26560356_Chip-Seq_TH2_Human	1.37006379
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36784897
35	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.35270685
36	RUNX_20019798_ChIP-Seq_JUKART_Human	1.31992283
37	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30616366
38	STAT1_20625510_ChIP-Seq_HELA_Human	1.29143525
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.26999259
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26143246
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26143246
42	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25971764
43	AR_20517297_ChIP-Seq_VCAP_Human	1.25955778
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23526074
45	EWS_26573619_Chip-Seq_HEK293_Human	1.21120573
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19982041
47	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.19155301
48	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.18385912
49	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.17919811
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17367466
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17082491
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15530083
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15110175
54	RAC3_21632823_ChIP-Seq_H3396_Human	1.14819681
55	CTCF_20526341_ChIP-Seq_ESCs_Human	1.13584436
56	NCOR_22424771_ChIP-Seq_293T_Human	1.12926561
57	P300_27268052_Chip-Seq_Bcells_Human	1.12727252
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12707524
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.11846726
60	ERA_21632823_ChIP-Seq_H3396_Human	1.11498598
61	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.10638600
62	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.09405884
63	GBX2_23144817_ChIP-Seq_PC3_Human	1.09280625
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.08792028
65	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08656730
66	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08595774
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.08521169
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08271374
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07117380
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06471243
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06290507
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05170474
73	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.04989184
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.03768218
75	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03296329
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03047322
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02163969
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01685861
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01382264
80	FUS_26573619_Chip-Seq_HEK293_Human	1.01100884
81	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00897435
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00802591
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00508383
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99627937
85	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99525317
86	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99257346
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99133333
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97417826
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97417826
90	GATA3_27048872_Chip-Seq_THYMUS_Human	0.96722108
91	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96596734
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.96252886
93	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94924424
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.94056675
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.92750234
96	E2F1_20622854_ChIP-Seq_HELA_Human	0.91758476
97	MYB_26560356_Chip-Seq_TH2_Human	0.91069649
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90292748
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.88467946
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88465691

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.93791184
2	MP0009379_abnormal_foot_pigmentation	3.81328740
3	MP0005671_abnormal_response_to	3.06929626
4	MP0006072_abnormal_retinal_apoptosis	2.79912702
5	MP0000685_abnormal_immune_system	2.54474384
6	MP0000372_irregular_coat_pigmentation	2.46519579
7	MP0005646_abnormal_pituitary_gland	2.36816775
8	MP0005075_abnormal_melanosome_morpholog	2.36483586
9	MP0002102_abnormal_ear_morphology	2.30918442
10	MP0001986_abnormal_taste_sensitivity	2.16479172
11	MP0006292_abnormal_olfactory_placode	2.13903950
12	MP0001835_abnormal_antigen_presentation	2.12229533
13	MP0002163_abnormal_gland_morphology	2.09346957
14	MP0001968_abnormal_touch/_nociception	2.06834915
15	MP0008872_abnormal_physiological_respon	2.03690826
16	MP0005387_immune_system_phenotype	2.02635329
17	MP0001790_abnormal_immune_system	2.02635329
18	MP0003786_premature_aging	1.92339122
19	MP0001984_abnormal_olfaction	1.90095926
20	MP0004381_abnormal_hair_follicle	1.81455020
21	MP0005670_abnormal_white_adipose	1.79434761
22	MP0002876_abnormal_thyroid_physiology	1.74596430
23	MP0004043_abnormal_pH_regulation	1.65555111
24	MP0008995_early_reproductive_senescence	1.64115808
25	MP0002736_abnormal_nociception_after	1.64009978
26	MP0008877_abnormal_DNA_methylation	1.61166701
27	MP0001800_abnormal_humoral_immune	1.58039918
28	MP0008875_abnormal_xenobiotic_pharmacok	1.56030492
29	MP0009333_abnormal_splenocyte_physiolog	1.54735618
30	MP0002166_altered_tumor_susceptibility	1.54555708
31	MP0002006_tumorigenesis	1.53647305
32	MP0004145_abnormal_muscle_electrophysio	1.53641963
33	MP0009764_decreased_sensitivity_to	1.46648657
34	MP0005645_abnormal_hypothalamus_physiol	1.43506079
35	MP0003136_yellow_coat_color	1.43031737
36	MP0003787_abnormal_imprinting	1.36341162
37	MP0001919_abnormal_reproductive_system	1.36252306
38	MP0005551_abnormal_eye_electrophysiolog	1.35682227
39	MP0005000_abnormal_immune_tolerance	1.31369240
40	MP0009785_altered_susceptibility_to	1.31012835
41	MP0002272_abnormal_nervous_system	1.29812769
42	MP0004142_abnormal_muscle_tone	1.28468141
43	MP0002733_abnormal_thermal_nociception	1.28432369
44	MP0005389_reproductive_system_phenotype	1.26188361
45	MP0002420_abnormal_adaptive_immunity	1.23130723
46	MP0001819_abnormal_immune_cell	1.22619713
47	MP0002723_abnormal_immune_serum	1.21386357
48	MP0003436_decreased_susceptibility_to	1.19846329
49	MP0001970_abnormal_pain_threshold	1.18675807
50	MP0002638_abnormal_pupillary_reflex	1.18531136
51	MP0002234_abnormal_pharynx_morphology	1.15273262
52	MP0008789_abnormal_olfactory_epithelium	1.14533703
53	MP0009745_abnormal_behavioral_response	1.10794149
54	MP0001501_abnormal_sleep_pattern	1.08591393
55	MP0002452_abnormal_antigen_presenting	1.06388236
56	MP0005253_abnormal_eye_physiology	1.05983643
57	MP0002254_reproductive_system_inflammat	1.03792806
58	MP0002148_abnormal_hypersensitivity_rea	1.03505720
59	MP0001873_stomach_inflammation	0.99491056
60	MP0004885_abnormal_endolymph	0.98472980
61	MP0002277_abnormal_respiratory_mucosa	0.98207831
62	MP0006276_abnormal_autonomic_nervous	0.97789964
63	MP0005025_abnormal_response_to	0.97044504
64	MP0003724_increased_susceptibility_to	0.95325786
65	MP0001502_abnormal_circadian_rhythm	0.93431151
66	MP0005379_endocrine/exocrine_gland_phen	0.90875003
67	MP0002653_abnormal_ependyma_morphology	0.89680455
68	MP0005408_hypopigmentation	0.88586777
69	MP0001905_abnormal_dopamine_level	0.87811470
70	MP0000716_abnormal_immune_system	0.85694146
71	MP0003183_abnormal_peptide_metabolism	0.85141048
72	MP0002837_dystrophic_cardiac_calcinosis	0.84177519
73	MP0005636_abnormal_mineral_homeostasis	0.83065391
74	MP0008007_abnormal_cellular_replicative	0.82435655
75	MP0002160_abnormal_reproductive_system	0.82252684
76	MP0001440_abnormal_grooming_behavior	0.81651568
77	MP0008775_abnormal_heart_ventricle	0.81424653
78	MP0005360_urolithiasis	0.81343754
79	MP0002735_abnormal_chemical_nociception	0.81083239
80	MP0002933_joint_inflammation	0.81028886
81	MP0002398_abnormal_bone_marrow	0.79736711
82	MP0006036_abnormal_mitochondrial_physio	0.77490926
83	MP0001765_abnormal_ion_homeostasis	0.76386278
84	MP0000631_abnormal_neuroendocrine_gland	0.75821127
85	MP0001293_anophthalmia	0.75043243
86	MP0005174_abnormal_tail_pigmentation	0.73761637
87	MP0000689_abnormal_spleen_morphology	0.72765326
88	MP0004133_heterotaxia	0.72194628
89	MP0002095_abnormal_skin_pigmentation	0.71013004
90	MP0001764_abnormal_homeostasis	0.70708333
91	MP0003045_fibrosis	0.69445398
92	MP0003763_abnormal_thymus_physiology	0.69206956
93	MP0002572_abnormal_emotion/affect_behav	0.68973716
94	MP0001845_abnormal_inflammatory_respons	0.68848259
95	MP0005448_abnormal_energy_balance	0.68823513
96	MP0005195_abnormal_posterior_eye	0.67616068
97	MP0002405_respiratory_system_inflammati	0.67449196
98	MP0005394_taste/olfaction_phenotype	0.67105405
99	MP0005499_abnormal_olfactory_system	0.67105405
100	MP0002822_catalepsy	0.66827696

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.70868123
2	Acute necrotizing encephalopathy (HP:0006965)	4.25070087
3	IgG deficiency (HP:0004315)	4.01836191
4	Mitochondrial inheritance (HP:0001427)	3.72409228
5	Congenital stationary night blindness (HP:0007642)	3.66519462
6	Acute encephalopathy (HP:0006846)	3.65033033
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.64264108
8	Progressive macrocephaly (HP:0004481)	3.38645921
9	Increased CSF lactate (HP:0002490)	3.38298177
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.35259703
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.28271368
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.26228616
13	Increased hepatocellular lipid droplets (HP:0006565)	3.23407872
14	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.23205337
15	Lipid accumulation in hepatocytes (HP:0006561)	3.21533209
16	Increased IgM level (HP:0003496)	3.20154549
17	Hepatocellular necrosis (HP:0001404)	3.01779357
18	Stenosis of the external auditory canal (HP:0000402)	2.91532511
19	Molar tooth sign on MRI (HP:0002419)	2.90282429
20	Abnormality of midbrain morphology (HP:0002418)	2.90282429
21	Pancreatic cysts (HP:0001737)	2.89196820
22	Increased intramyocellular lipid droplets (HP:0012240)	2.87142212
23	Hepatic necrosis (HP:0002605)	2.85418615
24	Abnormal number of erythroid precursors (HP:0012131)	2.84026085
25	Abnormality of the renal cortex (HP:0011035)	2.80592899
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.77548904
27	Optic disc pallor (HP:0000543)	2.75273436
28	Absent thumb (HP:0009777)	2.73433432
29	Nephronophthisis (HP:0000090)	2.68931268
30	Hypoproteinemia (HP:0003075)	2.67765402
31	3-Methylglutaconic aciduria (HP:0003535)	2.67403824
32	Macrocytic anemia (HP:0001972)	2.65515811
33	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.65403767
34	Cerebral edema (HP:0002181)	2.63880785
35	Increased serum lactate (HP:0002151)	2.56661260
36	Pancreatic fibrosis (HP:0100732)	2.55506342
37	True hermaphroditism (HP:0010459)	2.50958887
38	Asplenia (HP:0001746)	2.50948740
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.50777485
40	Exertional dyspnea (HP:0002875)	2.49066599
41	Increased muscle lipid content (HP:0009058)	2.48551793
42	Keratoconus (HP:0000563)	2.46770708
43	Increased corneal curvature (HP:0100692)	2.46770708
44	Renal Fanconi syndrome (HP:0001994)	2.46561753
45	Pendular nystagmus (HP:0012043)	2.45280331
46	Aplastic anemia (HP:0001915)	2.45188991
47	Type II lissencephaly (HP:0007260)	2.44892500
48	Retrobulbar optic neuritis (HP:0100654)	2.44770266
49	Optic neuritis (HP:0100653)	2.44770266
50	Abnormality of the renal medulla (HP:0100957)	2.43885973
51	Constricted visual fields (HP:0001133)	2.35932667
52	Pallor (HP:0000980)	2.31656657
53	Oligodactyly (hands) (HP:0001180)	2.28176031
54	Medial flaring of the eyebrow (HP:0010747)	2.26841591
55	Decreased central vision (HP:0007663)	2.24288821
56	Abnormality of DNA repair (HP:0003254)	2.23525113
57	Generalized aminoaciduria (HP:0002909)	2.22122936
58	Respiratory difficulties (HP:0002880)	2.16813932
59	Stomatitis (HP:0010280)	2.16060537
60	Severe combined immunodeficiency (HP:0004430)	2.12242804
61	Lactic acidosis (HP:0003128)	2.11987983
62	Myositis (HP:0100614)	2.11735204
63	Renal cortical cysts (HP:0000803)	2.07813270
64	Dyschromatopsia (HP:0007641)	2.07761722
65	Attenuation of retinal blood vessels (HP:0007843)	2.07629104
66	Encephalitis (HP:0002383)	2.07290764
67	Pancytopenia (HP:0001876)	2.07249549
68	Septo-optic dysplasia (HP:0100842)	2.06778113
69	Exercise intolerance (HP:0003546)	2.06314723
70	Abnormality of the renal collecting system (HP:0004742)	2.04391285
71	Glycosuria (HP:0003076)	2.03896986
72	Abnormality of urine glucose concentration (HP:0011016)	2.03896986
73	Congenital, generalized hypertrichosis (HP:0004540)	1.93534443
74	Abolished electroretinogram (ERG) (HP:0000550)	1.91280691
75	Lethargy (HP:0001254)	1.89847879
76	Type 2 muscle fiber atrophy (HP:0003554)	1.89086522
77	Conical tooth (HP:0000698)	1.87283362
78	Orchitis (HP:0100796)	1.85368465
79	Cerebellar dysplasia (HP:0007033)	1.85174007
80	Central scotoma (HP:0000603)	1.84696729
81	Tubular atrophy (HP:0000092)	1.83226057
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82767185
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82767185
84	Respiratory failure (HP:0002878)	1.80220725
85	Methylmalonic acidemia (HP:0002912)	1.77455950
86	Hyperglycinemia (HP:0002154)	1.77217650
87	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76826466
88	Abnormality of eosinophils (HP:0001879)	1.75459818
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74684878
90	Abnormality of alanine metabolism (HP:0010916)	1.74684878
91	Hyperalaninemia (HP:0003348)	1.74684878
92	Horseshoe kidney (HP:0000085)	1.72957200
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72760705
94	Keratoconjunctivitis (HP:0001096)	1.72670584
95	Hyperglycinuria (HP:0003108)	1.72491094
96	Hypoplasia of the radius (HP:0002984)	1.71934394
97	Hypoplasia of the uterus (HP:0000013)	1.71528506
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.70417065
99	Dicarboxylic aciduria (HP:0003215)	1.70417065
100	Testicular atrophy (HP:0000029)	1.68867063

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.55661042
2	WNK4	3.31799293
3	KDR	3.03232171
4	TXK	3.02212516
5	TLK1	2.99840576
6	VRK2	2.95356452
7	ADRBK2	2.79968915
8	MAP4K2	2.50553451
9	NUAK1	2.37736723
10	ZAK	2.31769049
11	GRK1	2.21345265
12	CAMKK2	2.19122098
13	GRK6	2.00481300
14	MAP2K6	1.95356334
15	MAP4K1	1.95141539
16	TIE1	1.71775146
17	STK39	1.46887520
18	OXSR1	1.46340599
19	MAP3K11	1.44755938
20	IKBKB	1.43447149
21	STK16	1.40656899
22	PINK1	1.40642544
23	MAP3K12	1.39422510
24	FRK	1.36289108
25	CAMKK1	1.31503863
26	FES	1.29936194
27	VRK1	1.27946744
28	BCKDK	1.25741522
29	LIMK1	1.20962100
30	PASK	1.19947948
31	TEC	1.16681638
32	DAPK2	1.08151893
33	KIT	1.05778623
34	WNK3	1.05640391
35	CDK19	1.04190271
36	IKBKE	1.03942780
37	DYRK2	0.99885917
38	BMPR2	0.97975600
39	ITK	0.97605201
40	TSSK6	0.96941082
41	LRRK2	0.96115014
42	INSRR	0.94773573
43	SYK	0.91909414
44	TESK2	0.89786220
45	PRKCQ	0.88138802
46	RPS6KA5	0.86542957
47	MAPK15	0.83340879
48	DAPK1	0.82977307
49	NME1	0.82209847
50	MYLK	0.82048468
51	MATK	0.81876027
52	ADRBK1	0.80822001
53	PLK4	0.80245812
54	GRK7	0.79447517
55	MAP2K2	0.78270708
56	MAPK13	0.76329652
57	NLK	0.73175209
58	BTK	0.71120092
59	LYN	0.69379479
60	GRK5	0.66465557
61	PHKG2	0.64976482
62	PHKG1	0.64976482
63	PRKCG	0.64930770
64	CSF1R	0.64745063
65	WNK1	0.64517031
66	CAMK1	0.58134889
67	OBSCN	0.58134666
68	CSNK1G3	0.54930993
69	PRKCA	0.52147192
70	DAPK3	0.51113352
71	IRAK1	0.49542322
72	PRKACA	0.49259660
73	LCK	0.48258171
74	NTRK2	0.47435663
75	IGF1R	0.47393344
76	PTK2B	0.47361298
77	ATR	0.46396853
78	BUB1	0.45805595
79	PRKCD	0.45269806
80	NTRK1	0.43992511
81	CSNK1G2	0.43811351
82	ZAP70	0.43442265
83	EPHA4	0.42985524
84	CSNK1G1	0.42587743
85	PIK3CG	0.42381299
86	CSNK1A1L	0.41518756
87	CAMK2A	0.41196052
88	SRPK1	0.41132827
89	PAK3	0.40949446
90	PRKCH	0.40308044
91	PIK3CA	0.39502891
92	PDK2	0.38068846
93	ILK	0.38065394
94	ERBB3	0.37557589
95	PIM1	0.36163442
96	PRKD3	0.35476163
97	MINK1	0.35328020
98	PRKCI	0.34540925
99	CSNK1D	0.34336610
100	CASK	0.33938821

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.88578588
2	Proteasome_Homo sapiens_hsa03050	3.56721914
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56647427
4	Parkinsons disease_Homo sapiens_hsa05012	3.01778338
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.75198773
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.65224671
7	Allograft rejection_Homo sapiens_hsa05330	2.54945282
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.53880680
9	Asthma_Homo sapiens_hsa05310	2.51819119
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.32616726
11	RNA polymerase_Homo sapiens_hsa03020	2.18377127
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18258508
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.12439475
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99344756
15	Huntingtons disease_Homo sapiens_hsa05016	1.99226108
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96780414
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91033134
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90966303
19	Alzheimers disease_Homo sapiens_hsa05010	1.90377760
20	Homologous recombination_Homo sapiens_hsa03440	1.74181093
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67051945
22	Phototransduction_Homo sapiens_hsa04744	1.61235606
23	Caffeine metabolism_Homo sapiens_hsa00232	1.59417147
24	Protein export_Homo sapiens_hsa03060	1.49696177
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49580745
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45246122
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37047704
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.34352440
29	One carbon pool by folate_Homo sapiens_hsa00670	1.31329771
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23996936
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21132289
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10603023
33	RNA degradation_Homo sapiens_hsa03018	1.03234432
34	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99843658
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98041907
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.94642270
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94246204
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94211220
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93910900
40	Rheumatoid arthritis_Homo sapiens_hsa05323	0.92850230
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92218299
42	Nicotine addiction_Homo sapiens_hsa05033	0.91530580
43	Peroxisome_Homo sapiens_hsa04146	0.89517334
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89260581
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.86607766
46	Olfactory transduction_Homo sapiens_hsa04740	0.83627933
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83609419
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82398906
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81835939
50	Mismatch repair_Homo sapiens_hsa03430	0.80102653
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79420865
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77863036
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.75604036
54	Spliceosome_Homo sapiens_hsa03040	0.72873419
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71462007
56	Purine metabolism_Homo sapiens_hsa00230	0.69714261
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68547701
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67095245
59	Viral myocarditis_Homo sapiens_hsa05416	0.66637385
60	Propanoate metabolism_Homo sapiens_hsa00640	0.66175076
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64299524
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63766349
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62584817
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62552027
65	RNA transport_Homo sapiens_hsa03013	0.62450872
66	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.62343812
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.61926270
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.61382881
69	Regulation of autophagy_Homo sapiens_hsa04140	0.60199153
70	Retinol metabolism_Homo sapiens_hsa00830	0.59112017
71	Basal transcription factors_Homo sapiens_hsa03022	0.58485234
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57051258
73	Butanoate metabolism_Homo sapiens_hsa00650	0.54983345
74	Taste transduction_Homo sapiens_hsa04742	0.53213545
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52062164
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.48477478
77	Metabolic pathways_Homo sapiens_hsa01100	0.46937407
78	Morphine addiction_Homo sapiens_hsa05032	0.46760805
79	Sulfur relay system_Homo sapiens_hsa04122	0.46196672
80	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45067913
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38916412
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37538547
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35734761
84	Salivary secretion_Homo sapiens_hsa04970	0.35337672
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.34711128
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34317391
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30769698
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.29886442
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29145383
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28954146
91	Serotonergic synapse_Homo sapiens_hsa04726	0.26665241
92	ABC transporters_Homo sapiens_hsa02010	0.26600895
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.25209815
94	DNA replication_Homo sapiens_hsa03030	0.24833765
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22161606
96	Malaria_Homo sapiens_hsa05144	0.21315565
97	Insulin secretion_Homo sapiens_hsa04911	0.20850258
98	Base excision repair_Homo sapiens_hsa03410	0.19614043
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18832065
100	Folate biosynthesis_Homo sapiens_hsa00790	0.18049970

RPL23AP41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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