ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.74210828
2	viral transcription (GO:0019083)	5.10502853
3	negative regulation of erythrocyte differentiation (GO:0045647)	4.93588171
4	translational termination (GO:0006415)	4.69790656
5	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.12582788
6	regulation of histone H3-K27 methylation (GO:0061085)	4.03241430
7	translational elongation (GO:0006414)	3.99891079
8	nuclear pore complex assembly (GO:0051292)	3.88126453
9	viral life cycle (GO:0019058)	3.83592252
10	ribosomal small subunit assembly (GO:0000028)	3.80735031
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.69035589
12	cellular protein complex disassembly (GO:0043624)	3.68945024
13	positive regulation of gamma-delta T cell activation (GO:0046645)	3.62944858
14	protein targeting to ER (GO:0045047)	3.62141957
15	formation of translation preinitiation complex (GO:0001731)	3.61673378
16	proline biosynthetic process (GO:0006561)	3.58706816
17	cotranslational protein targeting to membrane (GO:0006613)	3.55145552
18	protein complex disassembly (GO:0043241)	3.48210985
19	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.47575080
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.47230951
21	COPI coating of Golgi vesicle (GO:0048205)	3.46034909
22	Golgi transport vesicle coating (GO:0048200)	3.46034909
23	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.45722287
24	regulation of RNA export from nucleus (GO:0046831)	3.43960806
25	regulation of translational fidelity (GO:0006450)	3.37974250
26	translational initiation (GO:0006413)	3.35901434
27	protein localization to endoplasmic reticulum (GO:0070972)	3.34338117
28	3-UTR-mediated mRNA stabilization (GO:0070935)	3.33009417
29	DNA unwinding involved in DNA replication (GO:0006268)	3.32448688
30	maturation of SSU-rRNA (GO:0030490)	3.26388725
31	macromolecular complex disassembly (GO:0032984)	3.16675591
32	antigen processing and presentation of endogenous antigen (GO:0019883)	3.16199471
33	thymic T cell selection (GO:0045061)	3.15451704
34	embryonic process involved in female pregnancy (GO:0060136)	3.13429978
35	regulation of nucleobase-containing compound transport (GO:0032239)	3.10320454
36	nuclear pore organization (GO:0006999)	3.08767286
37	modulation by virus of host process (GO:0019054)	3.08276988
38	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.07581997
39	positive thymic T cell selection (GO:0045059)	3.02548548
40	modulation by symbiont of host cellular process (GO:0044068)	3.02508584
41	mRNA stabilization (GO:0048255)	2.99358834
42	RNA stabilization (GO:0043489)	2.99358834
43	mitotic chromosome condensation (GO:0007076)	2.92219015
44	positive regulation of B cell differentiation (GO:0045579)	2.91043669
45	regulation of gamma-delta T cell differentiation (GO:0045586)	2.89796566
46	regulation of early endosome to late endosome transport (GO:2000641)	2.85956673
47	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.84440005
48	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.76202298
49	pore complex assembly (GO:0046931)	2.76198167
50	mannose metabolic process (GO:0006013)	2.73428093
51	pinocytosis (GO:0006907)	2.72824406
52	Peyers patch development (GO:0048541)	2.71478046
53	mucosal-associated lymphoid tissue development (GO:0048537)	2.71478046
54	response to laminar fluid shear stress (GO:0034616)	2.68945171
55	protein targeting to membrane (GO:0006612)	2.65415584
56	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.64694593
57	B cell receptor signaling pathway (GO:0050853)	2.64108049
58	ribonucleoprotein complex biogenesis (GO:0022613)	2.61489673
59	cellular hyperosmotic response (GO:0071474)	2.59771251
60	regulation of gamma-delta T cell activation (GO:0046643)	2.58813539
61	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.58453078
62	DNA topological change (GO:0006265)	2.56329058
63	ribosomal large subunit biogenesis (GO:0042273)	2.53548296
64	T cell selection (GO:0045058)	2.53480148
65	cellular response to epidermal growth factor stimulus (GO:0071364)	2.50942698
66	poly(A)+ mRNA export from nucleus (GO:0016973)	2.49120183
67	trophectodermal cell differentiation (GO:0001829)	2.48900543
68	pentose-phosphate shunt (GO:0006098)	2.48491897
69	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.47055122
70	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.47055122
71	modulation by symbiont of host immune response (GO:0052553)	2.47055122
72	positive regulation by symbiont of host defense response (GO:0052509)	2.47055122
73	modulation by symbiont of host defense response (GO:0052031)	2.47055122
74	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.47055122
75	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.46691603
76	response to epidermal growth factor (GO:0070849)	2.45526779
77	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.45083317
78	regulation of response to osmotic stress (GO:0047484)	2.44626380
79	apoptotic process involved in morphogenesis (GO:0060561)	2.44228153
80	regulation of chromatin binding (GO:0035561)	2.44088014
81	regulation of superoxide anion generation (GO:0032928)	2.43609978
82	cell-substrate adherens junction assembly (GO:0007045)	2.43537321
83	focal adhesion assembly (GO:0048041)	2.43537321
84	protein export from nucleus (GO:0006611)	2.43487926
85	negative regulation of necroptotic process (GO:0060546)	2.42340288
86	erythrocyte maturation (GO:0043249)	2.42266327
87	positive T cell selection (GO:0043368)	2.41627834
88	negative thymic T cell selection (GO:0045060)	2.39648270
89	proline metabolic process (GO:0006560)	2.39108620
90	histone H3-K36 demethylation (GO:0070544)	2.39097619
91	heterochromatin organization (GO:0070828)	2.38509741
92	mRNA catabolic process (GO:0006402)	2.37533308
93	negative regulation of cell size (GO:0045792)	2.35361286
94	megakaryocyte development (GO:0035855)	2.34719789
95	activation of MAPKKK activity (GO:0000185)	2.33732626
96	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.33622240
97	negative regulation of cell killing (GO:0031342)	2.27877932
98	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.27877932
99	negative T cell selection (GO:0043383)	2.27171045
100	definitive hemopoiesis (GO:0060216)	2.27047112

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.88966521
2	MYC_22102868_ChIP-Seq_BL_Human	3.58845018
3	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.01064725
4	VDR_21846776_ChIP-Seq_THP-1_Human	2.98260210
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.83109067
6	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.57070374
7	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.42754863
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.28481777
9	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.24313696
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13655656
11	LXR_22292898_ChIP-Seq_THP-1_Human	2.12462685
12	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.10330621
13	TCF7_22412390_ChIP-Seq_EML_Mouse	2.05074009
14	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.01128044
15	MAF_26560356_Chip-Seq_TH1_Human	1.90764968
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.89256019
17	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.86232371
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84437262
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.81414430
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.79934037
21	KDM2B_26808549_Chip-Seq_DND41_Human	1.78405010
22	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.75708500
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.74038286
24	NCOR1_26117541_ChIP-Seq_K562_Human	1.70172023
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.65660201
26	UTX_26944678_Chip-Seq_JUKART_Human	1.65162999
27	MAF_26560356_Chip-Seq_TH2_Human	1.63146432
28	XRN2_22483619_ChIP-Seq_HELA_Human	1.62345124
29	VDR_24763502_ChIP-Seq_THP-1_Human	1.62251620
30	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.55608122
31	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.54464722
32	CIITA_25753668_ChIP-Seq_RAJI_Human	1.51810666
33	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.50375121
34	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.47689180
35	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.47111941
36	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.46348457
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46085839
38	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.45291773
39	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.42468430
40	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.42145718
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.42132946
42	CLOCK_20551151_ChIP-Seq_293T_Human	1.41930033
43	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.40965563
44	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.39082219
45	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.37654652
46	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.36207786
47	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35436295
48	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.34084528
49	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.34013547
50	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.33042307
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31146599
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.30714113
53	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.30685155
54	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.30666556
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28790317
56	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.27092824
57	MYB_26560356_Chip-Seq_TH1_Human	1.26762525
58	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.26656842
59	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.23384970
60	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.22994023
61	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.22456961
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.21396521
63	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21314912
64	P68_20966046_ChIP-Seq_HELA_Human	1.18511307
65	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.15463563
66	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.13442736
67	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13272666
68	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.13222849
69	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12822878
70	SPI1_23127762_ChIP-Seq_K562_Human	1.12478523
71	KDM2B_26808549_Chip-Seq_K562_Human	1.12245787
72	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11942986
73	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.11855797
74	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.11540802
75	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11251419
76	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.10688907
77	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.10676362
78	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.09326323
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.09117592
80	SPI1_23547873_ChIP-Seq_NB4_Human	1.08789519
81	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.07867374
82	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.07486091
83	GATA1_19941826_ChIP-Seq_K562_Human	1.05736348
84	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.04419796
85	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04129609
86	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.04114432
87	MYB_26560356_Chip-Seq_TH2_Human	1.03983578
88	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03636383
89	ATF3_27146783_Chip-Seq_COLON_Human	1.03068463
90	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.02860592
91	CREB1_26743006_Chip-Seq_LNCaP_Human	1.02525438
92	SCL_19346495_ChIP-Seq_HPC-7_Human	1.01295116
93	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.01114768
94	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.00617280
95	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.99553828
96	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.99213343
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98629226
98	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.98293191
99	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.98243105
100	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97395956

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	3.51033631
2	MP0003705_abnormal_hypodermis_morpholog	2.89456833
3	MP0003763_abnormal_thymus_physiology	2.60389134
4	MP0002396_abnormal_hematopoietic_system	2.26360837
5	MP0003436_decreased_susceptibility_to	2.24647563
6	MP0004185_abnormal_adipocyte_glucose	2.22386374
7	MP0005076_abnormal_cell_differentiation	2.17070542
8	MP0009333_abnormal_splenocyte_physiolog	2.09513374
9	MP0003300_gastrointestinal_ulcer	2.05321194
10	MP0002877_abnormal_melanocyte_morpholog	1.95608366
11	MP0000678_abnormal_parathyroid_gland	1.95584427
12	MP0002009_preneoplasia	1.83018166
13	MP0003303_peritoneal_inflammation	1.80203871
14	MP0003111_abnormal_nucleus_morphology	1.78362485
15	MP0000685_abnormal_immune_system	1.76313133
16	MP0000703_abnormal_thymus_morphology	1.75135941
17	MP0001873_stomach_inflammation	1.73101608
18	MP0000858_altered_metastatic_potential	1.69393989
19	MP0002166_altered_tumor_susceptibility	1.66984654
20	MP0004947_skin_inflammation	1.64682416
21	MP0009278_abnormal_bone_marrow	1.62683477
22	MP0002398_abnormal_bone_marrow	1.61985571
23	MP0005058_abnormal_lysosome_morphology	1.59180354
24	MP0001835_abnormal_antigen_presentation	1.57292214
25	MP0002132_abnormal_respiratory_system	1.57215572
26	MP0001730_embryonic_growth_arrest	1.49615584
27	MP0004957_abnormal_blastocyst_morpholog	1.47140134
28	MP0004808_abnormal_hematopoietic_stem	1.45469476
29	MP0004264_abnormal_extraembryonic_tissu	1.44792375
30	MP0002722_abnormal_immune_system	1.40468424
31	MP0001800_abnormal_humoral_immune	1.39785922
32	MP0005666_abnormal_adipose_tissue	1.39651396
33	MP0000350_abnormal_cell_proliferation	1.35164176
34	MP0003693_abnormal_embryo_hatching	1.35083117
35	MP0005000_abnormal_immune_tolerance	1.31230598
36	MP0005025_abnormal_response_to	1.29670957
37	MP0003077_abnormal_cell_cycle	1.29273467
38	MP0005387_immune_system_phenotype	1.29214896
39	MP0001790_abnormal_immune_system	1.29214896
40	MP0002420_abnormal_adaptive_immunity	1.27626469
41	MP0005464_abnormal_platelet_physiology	1.27089582
42	MP0001819_abnormal_immune_cell	1.25245397
43	MP0002933_joint_inflammation	1.23625745
44	MP0002429_abnormal_blood_cell	1.23593156
45	MP0004233_abnormal_muscle_weight	1.22212545
46	MP0001348_abnormal_lacrimal_gland	1.21969444
47	MP0003566_abnormal_cell_adhesion	1.21541433
48	MP0000716_abnormal_immune_system	1.21241684
49	MP0005671_abnormal_response_to	1.20678716
50	MP0001661_extended_life_span	1.19569183
51	MP0004858_abnormal_nervous_system	1.17135955
52	MP0009840_abnormal_foam_cell	1.17091988
53	MP0010155_abnormal_intestine_physiology	1.16278668
54	MP0001853_heart_inflammation	1.16270243
55	MP0010307_abnormal_tumor_latency	1.16204647
56	MP0002723_abnormal_immune_serum	1.15667227
57	MP0000689_abnormal_spleen_morphology	1.13823264
58	MP0003453_abnormal_keratinocyte_physiol	1.12274332
59	MP0008260_abnormal_autophagy	1.11094343
60	MP0008438_abnormal_cutaneous_collagen	1.10639698
61	MP0000490_abnormal_crypts_of	1.10229315
62	MP0002452_abnormal_antigen_presenting	1.07876898
63	MP0002419_abnormal_innate_immunity	1.06910260
64	MP0010094_abnormal_chromosome_stability	1.06753144
65	MP0005375_adipose_tissue_phenotype	1.06444627
66	MP0002796_impaired_skin_barrier	1.04622152
67	MP0010234_abnormal_vibrissa_follicle	1.02983356
68	MP0010630_abnormal_cardiac_muscle	1.02919356
69	MP0002249_abnormal_larynx_morphology	1.02870661
70	MP0002086_abnormal_extraembryonic_tissu	1.02079724
71	MP0003984_embryonic_growth_retardation	1.01647505
72	MP0003191_abnormal_cellular_cholesterol	1.01251070
73	MP0003656_abnormal_erythrocyte_physiolo	1.00867409
74	MP0002405_respiratory_system_inflammati	1.00384319
75	MP0000313_abnormal_cell_death	0.99882058
76	MP0010352_gastrointestinal_tract_polyps	0.97981406
77	MP0001545_abnormal_hematopoietic_system	0.96823593
78	MP0005397_hematopoietic_system_phenotyp	0.96823593
79	MP0005380_embryogenesis_phenotype	0.96627963
80	MP0001672_abnormal_embryogenesis/_devel	0.96627963
81	MP0002019_abnormal_tumor_incidence	0.96046264
82	MP0002088_abnormal_embryonic_growth/wei	0.95752718
83	MP0002080_prenatal_lethality	0.95471821
84	MP0001915_intracranial_hemorrhage	0.94862891
85	MP0000733_abnormal_muscle_development	0.93456428
86	MP0009379_abnormal_foot_pigmentation	0.92979869
87	MP0003866_abnormal_defecation	0.92484409
88	MP0004381_abnormal_hair_follicle	0.91876595
89	MP0008007_abnormal_cellular_replicative	0.91821542
90	MP0008057_abnormal_DNA_replication	0.89700755
91	MP0005501_abnormal_skin_physiology	0.89192410
92	MP0002006_tumorigenesis	0.88973438
93	MP0000003_abnormal_adipose_tissue	0.87594202
94	MP0005083_abnormal_biliary_tract	0.87072687
95	MP0004087_abnormal_muscle_fiber	0.85601094
96	MP0001849_ear_inflammation	0.85172957
97	MP0000609_abnormal_liver_physiology	0.84848627
98	MP0000759_abnormal_skeletal_muscle	0.84532636
99	MP0009931_abnormal_skin_appearance	0.84282648
100	MP0002139_abnormal_hepatobiliary_system	0.83471309

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	3.28723883
2	Abnormality of the fingertips (HP:0001211)	3.13036435
3	Abnormal gallbladder physiology (HP:0012438)	2.89804143
4	Cholecystitis (HP:0001082)	2.89804143
5	Colitis (HP:0002583)	2.88288645
6	Eczematoid dermatitis (HP:0000976)	2.87995374
7	Polycythemia (HP:0001901)	2.81056228
8	Asymmetry of the thorax (HP:0001555)	2.78216951
9	Ankyloglossia (HP:0010296)	2.70886333
10	Seborrheic dermatitis (HP:0001051)	2.62503979
11	Cellulitis (HP:0100658)	2.61764908
12	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.53972014
13	Disproportionate tall stature (HP:0001519)	2.52768680
14	Reticulocytosis (HP:0001923)	2.52652098
15	Abnormality of reticulocytes (HP:0004312)	2.44846911
16	Protrusio acetabuli (HP:0003179)	2.38400223
17	Increased IgE level (HP:0003212)	2.37829842
18	Gastrointestinal inflammation (HP:0004386)	2.37121434
19	Fatigue (HP:0012378)	2.36468442
20	Gastrointestinal stroma tumor (HP:0100723)	2.35160284
21	Abnormality of oral frenula (HP:0000190)	2.34838889
22	Flat acetabular roof (HP:0003180)	2.34517314
23	Truncus arteriosus (HP:0001660)	2.30526136
24	Hypertensive crisis (HP:0100735)	2.29706110
25	Reticulocytopenia (HP:0001896)	2.28369293
26	Hyperacusis (HP:0010780)	2.24844003
27	Pallor (HP:0000980)	2.21818371
28	Increased connective tissue (HP:0009025)	2.20768367
29	Rectal prolapse (HP:0002035)	2.20083709
30	Abnormality of cells of the erythroid lineage (HP:0012130)	2.16531788
31	Segmental peripheral demyelination/remyelination (HP:0003481)	2.14940870
32	Hemorrhage of the eye (HP:0011885)	2.13401434
33	Gastrointestinal infarctions (HP:0005244)	2.12902722
34	Achilles tendon contracture (HP:0001771)	2.09629463
35	Inflammation of the large intestine (HP:0002037)	2.07664760
36	Obstructive lung disease (HP:0006536)	2.06924693
37	Chronic obstructive pulmonary disease (HP:0006510)	2.06924693
38	Abnormality of the Achilles tendon (HP:0005109)	2.06033823
39	Vertebral compression fractures (HP:0002953)	2.05122097
40	Dysmetric saccades (HP:0000641)	2.04990293
41	Trismus (HP:0000211)	2.04790198
42	Recurrent viral infections (HP:0004429)	2.02414353
43	Agammaglobulinemia (HP:0004432)	2.01146882
44	Abnormality of the common coagulation pathway (HP:0010990)	1.98046073
45	Emphysema (HP:0002097)	1.97703485
46	Myopathic facies (HP:0002058)	1.96357582
47	Small epiphyses (HP:0010585)	1.92843038
48	Bowel incontinence (HP:0002607)	1.91269643
49	Metaphyseal cupping (HP:0003021)	1.90421558
50	Spinal cord lesions (HP:0100561)	1.88101786
51	Syringomyelia (HP:0003396)	1.88101786
52	Abnormality of complement system (HP:0005339)	1.87790282
53	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.85723833
54	Meningitis (HP:0001287)	1.84430530
55	Biconcave vertebral bodies (HP:0004586)	1.83274739
56	Premature skin wrinkling (HP:0100678)	1.82389017
57	Granulocytopenia (HP:0001913)	1.80901280
58	Progressive muscle weakness (HP:0003323)	1.78329992
59	Deep palmar crease (HP:0006191)	1.78212698
60	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.77542394
61	Abnormal large intestine physiology (HP:0012700)	1.75451129
62	Dilatation of the ascending aorta (HP:0005111)	1.74723736
63	Abnormality of the thoracic spine (HP:0100711)	1.74441659
64	Progressive external ophthalmoplegia (HP:0000590)	1.72719299
65	Macrocytic anemia (HP:0001972)	1.71715920
66	Thin ribs (HP:0000883)	1.71239145
67	Ulnar deviation of the wrist (HP:0003049)	1.71146724
68	Ragged-red muscle fibers (HP:0003200)	1.70894279
69	Nasal polyposis (HP:0100582)	1.70774508
70	Exercise-induced myalgia (HP:0003738)	1.69381133
71	Dislocated radial head (HP:0003083)	1.69234740
72	Cholelithiasis (HP:0001081)	1.69172508
73	Viral hepatitis (HP:0006562)	1.68988582
74	Abnormality of macrophages (HP:0004311)	1.68884531
75	Abnormality of the peritoneum (HP:0002585)	1.68275939
76	Thin bony cortex (HP:0002753)	1.67807495
77	Easy fatigability (HP:0003388)	1.67081247
78	Increased variability in muscle fiber diameter (HP:0003557)	1.65245140
79	Overlapping toe (HP:0001845)	1.64871940
80	Insomnia (HP:0100785)	1.64708136
81	Papilloma (HP:0012740)	1.64031689
82	Verrucae (HP:0200043)	1.64031689
83	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.63780943
84	Hypoparathyroidism (HP:0000829)	1.62890398
85	Hyperthyroidism (HP:0000836)	1.62206636
86	Abnormality of the calcaneus (HP:0008364)	1.61561673
87	Increased serum ferritin (HP:0003281)	1.61512423
88	Abnormality of carpal bone ossification (HP:0006257)	1.61276549
89	IgM deficiency (HP:0002850)	1.60743859
90	Abnormality of skeletal muscle fiber size (HP:0012084)	1.60513984
91	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.59247065
92	Autoimmune hemolytic anemia (HP:0001890)	1.58706209
93	Abnormality of the tricuspid valve (HP:0001702)	1.57616047
94	Thoracic kyphosis (HP:0002942)	1.57195399
95	Spontaneous hematomas (HP:0007420)	1.56843169
96	Abnormal tarsal ossification (HP:0008369)	1.56519242
97	Interstitial pulmonary disease (HP:0006530)	1.56220680
98	Abnormal ossification of hand bones (HP:0005921)	1.55982921
99	Abnormality of the nasal mucosa (HP:0000433)	1.55447333
100	Polygenic inheritance (HP:0010982)	1.55437312

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.40252861
2	PRPF4B	3.65092810
3	EEF2K	3.61659503
4	CDK12	3.13441537
5	ICK	2.86315310
6	SMG1	2.85247013
7	ERN1	2.76024503
8	RIPK4	2.54960186
9	MAP4K1	2.48278357
10	MAP3K10	2.44347095
11	NME2	2.25672404
12	FGFR4	2.22119157
13	MAP3K13	1.91517737
14	KSR2	1.68444494
15	IRAK3	1.66375159
16	SIK1	1.61726643
17	PKN2	1.52609508
18	LRRK2	1.52050485
19	MAP2K3	1.45050540
20	PASK	1.32916171
21	RPS6KB2	1.32679501
22	CDK4	1.22437343
23	FGFR3	1.16676955
24	SCYL2	1.11896938
25	ZAP70	1.05409777
26	MAP3K14	1.03570173
27	IRAK4	1.02897937
28	BTK	1.01985135
29	TYK2	1.01954190
30	MAP3K8	1.00235476
31	RIPK1	0.97689753
32	CLK1	0.96822700
33	SIK2	0.96223550
34	PDGFRA	0.95455823
35	MTOR	0.94450442
36	TAOK2	0.93453572
37	MAP3K1	0.89597119
38	JAK3	0.88543772
39	PTK6	0.88432825
40	MARK3	0.87391378
41	MAPK11	0.86780381
42	PDPK1	0.86719478
43	TESK2	0.84524294
44	TTN	0.84168773
45	STK10	0.83652579
46	MARK2	0.83445234
47	RET	0.81900158
48	MAP2K2	0.80671331
49	ARAF	0.78156452
50	BRAF	0.78155473
51	CDK7	0.77463282
52	CDC42BPA	0.77047009
53	GRK6	0.76965159
54	TYRO3	0.72284322
55	EIF2AK1	0.70548579
56	RAF1	0.70104762
57	BRD4	0.69553857
58	MAP3K2	0.68187079
59	HCK	0.67953195
60	HIPK2	0.65574444
61	TBK1	0.65134286
62	PDK1	0.63903418
63	MAP3K7	0.63200171
64	CDK6	0.62700615
65	ILK	0.61123667
66	EPHB1	0.58911760
67	MAPK12	0.55947600
68	CSK	0.55787033
69	ITK	0.55541721
70	PIM1	0.55361084
71	FES	0.54551394
72	BMPR2	0.53729245
73	SIK3	0.53124714
74	NEK2	0.52447804
75	JAK2	0.51986431
76	SYK	0.50115512
77	CHEK1	0.47307568
78	IRAK2	0.46256678
79	TTK	0.45833983
80	PRKD2	0.43161790
81	LCK	0.42460888
82	RPS6KC1	0.42003963
83	RPS6KL1	0.42003963
84	BLK	0.41698899
85	PAK4	0.41637351
86	JAK1	0.40934320
87	BMX	0.40184346
88	CAMK1D	0.39929694
89	TXK	0.39909583
90	TAOK1	0.38068988
91	MAP3K3	0.37666511
92	CDK2	0.36969115
93	MOS	0.36853514
94	TNK2	0.36579095
95	STK4	0.36230808
96	CAMKK1	0.36046176
97	LATS2	0.35174374
98	AKT2	0.33014764
99	KDR	0.32680817
100	MAPKAPK2	0.32467461

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	2.74316924
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.65454973
3	Acute myeloid leukemia_Homo sapiens_hsa05221	2.60215790
4	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.36951796
5	B cell receptor signaling pathway_Homo sapiens_hsa04662	2.33408355
6	Non-small cell lung cancer_Homo sapiens_hsa05223	2.25378942
7	Pancreatic cancer_Homo sapiens_hsa05212	1.93181454
8	Other glycan degradation_Homo sapiens_hsa00511	1.78982845
9	Thyroid cancer_Homo sapiens_hsa05216	1.65902686
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.62229058
11	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.54785909
12	Leishmaniasis_Homo sapiens_hsa05140	1.47581407
13	mTOR signaling pathway_Homo sapiens_hsa04150	1.46077457
14	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.42500230
15	Pentose phosphate pathway_Homo sapiens_hsa00030	1.38226431
16	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.38206368
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.37728545
18	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.37601850
19	Prion diseases_Homo sapiens_hsa05020	1.37299847
20	Viral carcinogenesis_Homo sapiens_hsa05203	1.33521326
21	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.32682474
22	Renal cell carcinoma_Homo sapiens_hsa05211	1.30179811
23	DNA replication_Homo sapiens_hsa03030	1.28554582
24	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.27867447
25	Bladder cancer_Homo sapiens_hsa05219	1.27395857
26	Spliceosome_Homo sapiens_hsa03040	1.26848266
27	Endometrial cancer_Homo sapiens_hsa05213	1.26266914
28	Herpes simplex infection_Homo sapiens_hsa05168	1.24945323
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.24136334
30	Hepatitis B_Homo sapiens_hsa05161	1.23328187
31	Measles_Homo sapiens_hsa05162	1.22643395
32	Osteoclast differentiation_Homo sapiens_hsa04380	1.22093944
33	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.14854209
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13565790
35	Colorectal cancer_Homo sapiens_hsa05210	1.13012803
36	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.11463716
37	Insulin signaling pathway_Homo sapiens_hsa04910	1.09792671
38	Influenza A_Homo sapiens_hsa05164	1.08019608
39	ErbB signaling pathway_Homo sapiens_hsa04012	1.07818865
40	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.06807814
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.05965400
42	Prostate cancer_Homo sapiens_hsa05215	1.05644680
43	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05633947
44	HTLV-I infection_Homo sapiens_hsa05166	1.05102712
45	Apoptosis_Homo sapiens_hsa04210	1.04958667
46	Glioma_Homo sapiens_hsa05214	1.03968607
47	Toxoplasmosis_Homo sapiens_hsa05145	1.03840367
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.02644233
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.99922762
50	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.99543671
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98952221
52	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.98582367
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97905963
54	Viral myocarditis_Homo sapiens_hsa05416	0.95616747
55	Small cell lung cancer_Homo sapiens_hsa05222	0.91537491
56	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.90840973
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90119791
58	Choline metabolism in cancer_Homo sapiens_hsa05231	0.88608496
59	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.87794045
60	Notch signaling pathway_Homo sapiens_hsa04330	0.85462584
61	Hepatitis C_Homo sapiens_hsa05160	0.84880688
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.82483413
63	Allograft rejection_Homo sapiens_hsa05330	0.82418955
64	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.81432311
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80419582
66	MicroRNAs in cancer_Homo sapiens_hsa05206	0.80042388
67	Prolactin signaling pathway_Homo sapiens_hsa04917	0.77947005
68	Insulin resistance_Homo sapiens_hsa04931	0.77575701
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.76452438
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.75098396
71	Galactose metabolism_Homo sapiens_hsa00052	0.74370451
72	Carbon metabolism_Homo sapiens_hsa01200	0.74098595
73	Cell cycle_Homo sapiens_hsa04110	0.74044794
74	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.73000496
75	TNF signaling pathway_Homo sapiens_hsa04668	0.72503130
76	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.71670977
77	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.70676330
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.70565705
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.70342225
80	Malaria_Homo sapiens_hsa05144	0.69758976
81	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68201939
82	One carbon pool by folate_Homo sapiens_hsa00670	0.67939200
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.67706529
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64650726
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.63306172
86	RNA transport_Homo sapiens_hsa03013	0.62103533
87	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61887392
88	Shigellosis_Homo sapiens_hsa05131	0.61881729
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.61370497
90	Proteoglycans in cancer_Homo sapiens_hsa05205	0.59392221
91	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.57997215
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57741509
93	Base excision repair_Homo sapiens_hsa03410	0.57591318
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57362160
95	Tuberculosis_Homo sapiens_hsa05152	0.56832956
96	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.56659182
97	Focal adhesion_Homo sapiens_hsa04510	0.54041377
98	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.52817385
99	Lysine degradation_Homo sapiens_hsa00310	0.51629843
100	Adherens junction_Homo sapiens_hsa04520	0.51456669

RPL23AP42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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