ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	7.16496713
2	ATP synthesis coupled proton transport (GO:0015986)	6.32440015
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.32440015
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.08007867
5	ribosomal small subunit assembly (GO:0000028)	5.94259372
6	chaperone-mediated protein transport (GO:0072321)	5.93521144
7	viral transcription (GO:0019083)	5.80161107
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.67505460
9	translational termination (GO:0006415)	5.49765514
10	DNA deamination (GO:0045006)	5.10589054
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.04176565
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.93701398
13	translational elongation (GO:0006414)	4.90135847
14	ncRNA 3-end processing (GO:0043628)	4.83497654
15	cotranslational protein targeting to membrane (GO:0006613)	4.83006458
16	protein targeting to ER (GO:0045047)	4.78629976
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.57504817
18	protein localization to endoplasmic reticulum (GO:0070972)	4.55583631
19	respiratory electron transport chain (GO:0022904)	4.44738448
20	electron transport chain (GO:0022900)	4.42342750
21	maturation of SSU-rRNA (GO:0030490)	4.41789033
22	neurofilament cytoskeleton organization (GO:0060052)	4.32560266
23	viral life cycle (GO:0019058)	4.32265185
24	ribosomal large subunit biogenesis (GO:0042273)	4.25219876
25	cellular protein complex disassembly (GO:0043624)	4.17107934
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.95795755
27	inner mitochondrial membrane organization (GO:0007007)	3.88610956
28	glyoxylate metabolic process (GO:0046487)	3.85395201
29	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.85376039
30	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.83272955
31	translational initiation (GO:0006413)	3.74539065
32	protein-cofactor linkage (GO:0018065)	3.70127933
33	ATP biosynthetic process (GO:0006754)	3.66670203
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.62891459
35	NADH dehydrogenase complex assembly (GO:0010257)	3.62891459
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.62891459
37	protein complex biogenesis (GO:0070271)	3.61282813
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.55160473
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.54519393
40	translation (GO:0006412)	3.53499174
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.48876575
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.45106662
43	intracellular protein transmembrane import (GO:0044743)	3.39371112
44	cellular component biogenesis (GO:0044085)	3.34590273
45	protein complex disassembly (GO:0043241)	3.30356259
46	hydrogen ion transmembrane transport (GO:1902600)	3.25974543
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25466849
48	regulation of activation of Janus kinase activity (GO:0010533)	3.19177085
49	negative regulation of mast cell activation (GO:0033004)	3.12334132
50	negative regulation of telomere maintenance (GO:0032205)	3.09681605
51	macromolecular complex disassembly (GO:0032984)	3.07430129
52	regulation of isotype switching to IgG isotypes (GO:0048302)	3.06398245
53	protein neddylation (GO:0045116)	3.06040036
54	protein targeting to membrane (GO:0006612)	3.04809743
55	protein targeting to mitochondrion (GO:0006626)	3.01507313
56	proton transport (GO:0015992)	3.00871212
57	regulation of natural killer cell mediated immunity (GO:0002715)	3.00740306
58	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.00740306
59	rRNA processing (GO:0006364)	3.00552095
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99532140
61	peptidyl-histidine modification (GO:0018202)	2.98556422
62	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.98355690
63	cytidine deamination (GO:0009972)	2.96785955
64	cytidine metabolic process (GO:0046087)	2.96785955
65	cytidine catabolic process (GO:0006216)	2.96785955
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96760998
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.95537025
68	rRNA metabolic process (GO:0016072)	2.95503960
69	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.94914248
70	hydrogen transport (GO:0006818)	2.94705392
71	mast cell activation (GO:0045576)	2.94136083
72	behavioral response to nicotine (GO:0035095)	2.93249440
73	GTP biosynthetic process (GO:0006183)	2.92530086
74	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.91793677
75	regulation of immunoglobulin secretion (GO:0051023)	2.90198770
76	regulation of DNA methylation (GO:0044030)	2.86761154
77	pseudouridine synthesis (GO:0001522)	2.80681558
78	regulation of regulatory T cell differentiation (GO:0045589)	2.78485917
79	mRNA catabolic process (GO:0006402)	2.76863019
80	male meiosis (GO:0007140)	2.76506716
81	establishment of protein localization to mitochondrion (GO:0072655)	2.76329948
82	regulation of chronic inflammatory response (GO:0002676)	2.75712486
83	proteasome assembly (GO:0043248)	2.74278543
84	positive regulation of prostaglandin secretion (GO:0032308)	2.72882335
85	S-adenosylmethionine metabolic process (GO:0046500)	2.68471638
86	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.67106279
87	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.66360644
88	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.65489217
89	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.65281031
90	termination of RNA polymerase III transcription (GO:0006386)	2.65281031
91	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.61732129
92	protein localization to mitochondrion (GO:0070585)	2.60522253
93	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.55710411
94	nucleoside triphosphate biosynthetic process (GO:0009142)	2.55599357
95	negative regulation of T cell differentiation in thymus (GO:0033085)	2.55380556
96	regulation of cellular amino acid metabolic process (GO:0006521)	2.54974117
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.52491728
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.52491728
99	regulation of B cell receptor signaling pathway (GO:0050855)	2.51651971
100	purine-containing compound salvage (GO:0043101)	2.48064680

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.03066389
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.84288509
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.60062292
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.58699800
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.44348480
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32889677
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.09541250
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83404348
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71244434
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.61174085
11	VDR_22108803_ChIP-Seq_LS180_Human	2.54581856
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45770920
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.26130314
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25311185
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.23442151
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.14753048
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12431351
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04739019
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.04173223
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01697016
21	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00181659
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.99353373
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96405479
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.88517913
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.86214549
26	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.80861413
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80244414
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.68250830
29	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65621416
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.64885905
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52149851
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.46305192
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42917532
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.40862134
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.39740342
36	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.39586795
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39085541
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36515168
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33652346
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31783700
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27421348
42	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26854327
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.26413922
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25438260
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25410945
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23724934
47	EWS_26573619_Chip-Seq_HEK293_Human	1.21373372
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19175852
49	GATA3_26560356_Chip-Seq_TH2_Human	1.17925201
50	NCOR_22424771_ChIP-Seq_293T_Human	1.17320059
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16016784
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16016784
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.15885163
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.15623622
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14609927
56	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14498810
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11971219
58	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11623272
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10476744
60	AR_20517297_ChIP-Seq_VCAP_Human	1.09481779
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08977899
62	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.08956525
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08214185
64	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.07920337
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07394783
66	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.06823657
67	ERA_21632823_ChIP-Seq_H3396_Human	1.05977400
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05636251
69	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.05490034
70	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05232778
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05198426
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04804473
73	GABP_19822575_ChIP-Seq_HepG2_Human	1.04788636
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03755794
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03320469
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02417534
77	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02396529
78	XRN2_22483619_ChIP-Seq_HELA_Human	1.01608418
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00280066
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98277657
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.96410070
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96410070
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96380773
84	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96134578
85	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.95962171
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95847065
87	BCL6_27268052_Chip-Seq_Bcells_Human	0.95363620
88	P300_27268052_Chip-Seq_Bcells_Human	0.92364021
89	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.92322068
90	E2F1_20622854_ChIP-Seq_HELA_Human	0.92056160
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.91605840
92	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.91067781
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.90952272
94	FUS_26573619_Chip-Seq_HEK293_Human	0.90747167
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.90610802
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90268779
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90266958
98	MYB_26560356_Chip-Seq_TH2_Human	0.87807704
99	RUNX_20019798_ChIP-Seq_JUKART_Human	0.86105111
100	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.85446849

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.15994283
2	MP0008995_early_reproductive_senescence	3.20670127
3	MP0001835_abnormal_antigen_presentation	3.15241556
4	MP0008875_abnormal_xenobiotic_pharmacok	3.13189408
5	MP0001873_stomach_inflammation	2.77572367
6	MP0006082_CNS_inflammation	2.71860466
7	MP0009379_abnormal_foot_pigmentation	2.66628027
8	MP0002876_abnormal_thyroid_physiology	2.60301380
9	MP0003646_muscle_fatigue	2.47961945
10	MP0006292_abnormal_olfactory_placode	2.42964648
11	MP0009785_altered_susceptibility_to	2.26536092
12	MP0003786_premature_aging	2.23789762
13	MP0003763_abnormal_thymus_physiology	2.04445705
14	MP0002148_abnormal_hypersensitivity_rea	2.04195646
15	MP0001800_abnormal_humoral_immune	1.96793901
16	MP0001986_abnormal_taste_sensitivity	1.94014211
17	MP0004147_increased_porphyrin_level	1.90860959
18	MP0009333_abnormal_splenocyte_physiolog	1.89186436
19	MP0005646_abnormal_pituitary_gland	1.83466741
20	MP0003195_calcinosis	1.82040599
21	MP0005075_abnormal_melanosome_morpholog	1.80635190
22	MP0004885_abnormal_endolymph	1.74491296
23	MP0005387_immune_system_phenotype	1.73879909
24	MP0001790_abnormal_immune_system	1.73879909
25	MP0000685_abnormal_immune_system	1.70626443
26	MP0005000_abnormal_immune_tolerance	1.66282629
27	MP0002163_abnormal_gland_morphology	1.65784396
28	MP0002723_abnormal_immune_serum	1.55804224
29	MP0004145_abnormal_muscle_electrophysio	1.55405865
30	MP0004142_abnormal_muscle_tone	1.55324071
31	MP0004510_myositis	1.51516305
32	MP0006072_abnormal_retinal_apoptosis	1.50579012
33	MP0002420_abnormal_adaptive_immunity	1.47740237
34	MP0008877_abnormal_DNA_methylation	1.46904094
35	MP0002277_abnormal_respiratory_mucosa	1.45385538
36	MP0001819_abnormal_immune_cell	1.42523375
37	MP0003806_abnormal_nucleotide_metabolis	1.42495220
38	MP0001968_abnormal_touch/_nociception	1.41816326
39	MP0008872_abnormal_physiological_respon	1.40476474
40	MP0003879_abnormal_hair_cell	1.37648208
41	MP0002837_dystrophic_cardiac_calcinosis	1.37636045
42	MP0002095_abnormal_skin_pigmentation	1.35769684
43	MP0002102_abnormal_ear_morphology	1.35507542
44	MP0002736_abnormal_nociception_after	1.35496588
45	MP0005551_abnormal_eye_electrophysiolog	1.33646709
46	MP0005025_abnormal_response_to	1.32102306
47	MP0001919_abnormal_reproductive_system	1.30488294
48	MP0002452_abnormal_antigen_presenting	1.30226861
49	MP0003866_abnormal_defecation	1.29552875
50	MP0003724_increased_susceptibility_to	1.29375457
51	MP0002398_abnormal_bone_marrow	1.25183806
52	MP0003436_decreased_susceptibility_to	1.20692931
53	MP0004742_abnormal_vestibular_system	1.20582109
54	MP0005377_hearing/vestibular/ear_phenot	1.19978860
55	MP0003878_abnormal_ear_physiology	1.19978860
56	MP0005389_reproductive_system_phenotype	1.17959005
57	MP0002405_respiratory_system_inflammati	1.14365925
58	MP0005645_abnormal_hypothalamus_physiol	1.12616640
59	MP0000716_abnormal_immune_system	1.12170297
60	MP0006036_abnormal_mitochondrial_physio	1.12165339
61	MP0002933_joint_inflammation	1.10956915
62	MP0001905_abnormal_dopamine_level	1.07100472
63	MP0001881_abnormal_mammary_gland	1.04902261
64	MP0003693_abnormal_embryo_hatching	1.03440110
65	MP0006276_abnormal_autonomic_nervous	1.03219673
66	MP0002138_abnormal_hepatobiliary_system	1.02559065
67	MP0002653_abnormal_ependyma_morphology	1.01581453
68	MP0000372_irregular_coat_pigmentation	1.01001859
69	MP0001663_abnormal_digestive_system	0.99745834
70	MP0005174_abnormal_tail_pigmentation	0.97880648
71	MP0002429_abnormal_blood_cell	0.97752917
72	MP0003186_abnormal_redox_activity	0.97296747
73	MP0005636_abnormal_mineral_homeostasis	0.97007015
74	MP0001845_abnormal_inflammatory_respons	0.96585759
75	MP0000689_abnormal_spleen_morphology	0.96340279
76	MP0010155_abnormal_intestine_physiology	0.95452654
77	MP0002160_abnormal_reproductive_system	0.94307797
78	MP0005410_abnormal_fertilization	0.92917911
79	MP0000015_abnormal_ear_pigmentation	0.91614626
80	MP0000703_abnormal_thymus_morphology	0.90952106
81	MP0009764_decreased_sensitivity_to	0.90916441
82	MP0001727_abnormal_embryo_implantation	0.88949947
83	MP0002272_abnormal_nervous_system	0.85458460
84	MP0005253_abnormal_eye_physiology	0.84768844
85	MP0002722_abnormal_immune_system	0.84620386
86	MP0008775_abnormal_heart_ventricle	0.82495371
87	MP0005332_abnormal_amino_acid	0.82153304
88	MP0005084_abnormal_gallbladder_morpholo	0.81083413
89	MP0009745_abnormal_behavioral_response	0.80460101
90	MP0005379_endocrine/exocrine_gland_phen	0.78887546
91	MP0001533_abnormal_skeleton_physiology	0.77330769
92	MP0001853_heart_inflammation	0.76867767
93	MP0003718_maternal_effect	0.76536802
94	MP0002419_abnormal_innate_immunity	0.75426721
95	MP0001119_abnormal_female_reproductive	0.75401566
96	MP0008058_abnormal_DNA_repair	0.75339619
97	MP0003011_delayed_dark_adaptation	0.75200202
98	MP0005085_abnormal_gallbladder_physiolo	0.74080280
99	MP0008469_abnormal_protein_level	0.74038401
100	MP0010094_abnormal_chromosome_stability	0.73008247

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.28977649
2	Acute necrotizing encephalopathy (HP:0006965)	4.74969470
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.23153936
4	Mitochondrial inheritance (HP:0001427)	4.16923075
5	Increased hepatocellular lipid droplets (HP:0006565)	4.03889077
6	Progressive macrocephaly (HP:0004481)	4.03631134
7	Acute encephalopathy (HP:0006846)	3.88642224
8	Increased CSF lactate (HP:0002490)	3.85851768
9	Aplastic anemia (HP:0001915)	3.82508764
10	Duplicated collecting system (HP:0000081)	3.81394879
11	Abnormality of the renal collecting system (HP:0004742)	3.67079247
12	Lipid accumulation in hepatocytes (HP:0006561)	3.66136466
13	3-Methylglutaconic aciduria (HP:0003535)	3.61207768
14	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.41617141
15	Renal Fanconi syndrome (HP:0001994)	3.40011121
16	Constricted visual fields (HP:0001133)	3.37562158
17	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.30856320
18	Absent thumb (HP:0009777)	3.28804811
19	Increased intramyocellular lipid droplets (HP:0012240)	3.28764895
20	Cerebral edema (HP:0002181)	3.27310779
21	Attenuation of retinal blood vessels (HP:0007843)	3.27097045
22	Abnormality of DNA repair (HP:0003254)	3.17917979
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.15695596
24	Hepatocellular necrosis (HP:0001404)	3.05115850
25	Optic disc pallor (HP:0000543)	3.02214767
26	Exertional dyspnea (HP:0002875)	2.96768289
27	Chromsome breakage (HP:0040012)	2.94163056
28	Abnormality of macular pigmentation (HP:0008002)	2.92804922
29	Hepatic necrosis (HP:0002605)	2.81877666
30	Oral leukoplakia (HP:0002745)	2.81850433
31	IgG deficiency (HP:0004315)	2.78414693
32	Pancytopenia (HP:0001876)	2.75388398
33	Increased muscle lipid content (HP:0009058)	2.75041877
34	Congenital stationary night blindness (HP:0007642)	2.73732387
35	Increased IgM level (HP:0003496)	2.73016678
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.71378353
37	Pallor (HP:0000980)	2.60197604
38	Increased serum lactate (HP:0002151)	2.58488144
39	Abnormality of pyrimidine metabolism (HP:0004353)	2.57745895
40	Congenital, generalized hypertrichosis (HP:0004540)	2.57609417
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.54075254
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.54075254
43	Lactic acidosis (HP:0003128)	2.47215251
44	Renal cortical cysts (HP:0000803)	2.44450674
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41672145
46	Autoimmune hemolytic anemia (HP:0001890)	2.41012653
47	Abnormality of B cell number (HP:0010975)	2.38270411
48	Autoimmune thrombocytopenia (HP:0001973)	2.36033613
49	Stomatitis (HP:0010280)	2.35829820
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.35207845
51	Abnormality of T cell number (HP:0011839)	2.34065135
52	Abnormality of T cells (HP:0002843)	2.32495468
53	Abnormal number of erythroid precursors (HP:0012131)	2.32197608
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.31862884
55	Meckel diverticulum (HP:0002245)	2.23938391
56	Molar tooth sign on MRI (HP:0002419)	2.23914389
57	Abnormality of midbrain morphology (HP:0002418)	2.23914389
58	Ectopic kidney (HP:0000086)	2.22869246
59	Testicular atrophy (HP:0000029)	2.19822103
60	Eosinophilia (HP:0001880)	2.19437896
61	Pancreatic cysts (HP:0001737)	2.17952118
62	Abnormality of eosinophils (HP:0001879)	2.12777048
63	Abnormality of the ileum (HP:0001549)	2.12149440
64	Macrocytic anemia (HP:0001972)	2.12121498
65	Respiratory failure (HP:0002878)	2.11275706
66	Hypoproteinemia (HP:0003075)	2.09569985
67	Thyroid-stimulating hormone excess (HP:0002925)	2.08949085
68	Glycosuria (HP:0003076)	2.08533102
69	Abnormality of urine glucose concentration (HP:0011016)	2.08533102
70	Abnormality of renal resorption (HP:0011038)	2.06711758
71	Abnormality of the renal cortex (HP:0011035)	2.06451411
72	Exercise intolerance (HP:0003546)	2.05529415
73	Neutropenia (HP:0001875)	2.05052760
74	IgM deficiency (HP:0002850)	2.00304487
75	Respiratory difficulties (HP:0002880)	1.99607642
76	Generalized aminoaciduria (HP:0002909)	1.98860909
77	Type 2 muscle fiber atrophy (HP:0003554)	1.94738358
78	Ureteral duplication (HP:0000073)	1.94276188
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.94057370
80	Leukodystrophy (HP:0002415)	1.93463975
81	Striae distensae (HP:0001065)	1.90361107
82	Lethargy (HP:0001254)	1.88763762
83	Type II lissencephaly (HP:0007260)	1.86566797
84	Hypomagnesemia (HP:0002917)	1.85647190
85	Clubbing of toes (HP:0100760)	1.80121505
86	Horseshoe kidney (HP:0000085)	1.79990478
87	Abnormality of the preputium (HP:0100587)	1.78290513
88	Abnormality of T cell physiology (HP:0011840)	1.77483693
89	T lymphocytopenia (HP:0005403)	1.76900162
90	Duplication of thumb phalanx (HP:0009942)	1.76541938
91	Pancreatic fibrosis (HP:0100732)	1.74945150
92	Methylmalonic acidemia (HP:0002912)	1.74415088
93	Concave nail (HP:0001598)	1.74356427
94	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.73671220
95	Stomach cancer (HP:0012126)	1.73605218
96	Hyperphosphaturia (HP:0003109)	1.72368454
97	Abolished electroretinogram (ERG) (HP:0000550)	1.71289907
98	Triphalangeal thumb (HP:0001199)	1.71077611
99	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.70872372
100	Round ear (HP:0100830)	1.69632897

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.46444171
2	TXK	5.77176773
3	MAP4K1	5.25583406
4	BCKDK	3.60508620
5	KIT	2.97347735
6	MAP4K2	2.28605735
7	ZAK	2.25875812
8	FES	2.24136332
9	TLK1	2.20945824
10	ADRBK2	1.92630729
11	NME2	1.85123387
12	TESK2	1.83939072
13	TEC	1.74148253
14	GRK1	1.65731785
15	NUAK1	1.58332404
16	WNK4	1.56640435
17	KDR	1.53093081
18	IKBKB	1.51335816
19	LIMK1	1.47990479
20	SYK	1.28335314
21	BMPR2	1.25017658
22	TIE1	1.23846212
23	FRK	1.22368066
24	CDK19	1.22061638
25	MST4	1.13976579
26	CDK8	1.03956446
27	ITK	1.02898309
28	IKBKE	0.90470433
29	EIF2AK1	0.90025793
30	NME1	0.88842451
31	OXSR1	0.88608454
32	BUB1	0.88586562
33	STK16	0.87904448
34	MUSK	0.85922825
35	ZAP70	0.84658922
36	LYN	0.83871315
37	LCK	0.81401693
38	SRPK1	0.76943387
39	INSRR	0.76643759
40	BMPR1B	0.76627857
41	BTK	0.76473218
42	CSF1R	0.74528089
43	RPS6KA5	0.74444679
44	CAMKK2	0.74296707
45	VRK1	0.71843550
46	ADRBK1	0.66255775
47	PASK	0.62717468
48	PIK3CA	0.61514978
49	VRK2	0.57717156
50	PINK1	0.57243268
51	GRK7	0.57215391
52	PHKG1	0.55847481
53	PHKG2	0.55847481
54	OBSCN	0.55510576
55	STK39	0.55140979
56	PRKCQ	0.54689397
57	ATR	0.54144115
58	DYRK2	0.53826296
59	CSK	0.53085684
60	GRK6	0.52253270
61	JAK3	0.51948190
62	MAPK13	0.47463625
63	TBK1	0.45755133
64	MAP2K6	0.45543936
65	PLK4	0.44246830
66	PIM1	0.43795315
67	PDK2	0.42287911
68	WNK3	0.41534977
69	CDK3	0.40902978
70	IGF1R	0.40573999
71	MAP2K2	0.38428207
72	PRKACA	0.37575347
73	CSNK2A2	0.37519910
74	TNK2	0.36951912
75	TYRO3	0.36587357
76	CSNK2A1	0.36135797
77	HCK	0.35994394
78	RPS6KA4	0.35652208
79	LRRK2	0.34544961
80	ABL2	0.33848488
81	GRK5	0.33802889
82	CSNK1A1	0.33773705
83	PIK3CG	0.32913289
84	CAMKK1	0.32779213
85	PRKCG	0.32385501
86	PRKCA	0.32215790
87	TESK1	0.31587199
88	MYLK	0.30525027
89	NEK1	0.29641055
90	ILK	0.28698800
91	MATK	0.25535733
92	MAP3K11	0.25323853
93	INSR	0.24472794
94	DAPK2	0.23706218
95	CAMK1	0.21592858
96	PRKCB	0.21220072
97	CAMK2A	0.20302915
98	AURKA	0.19778084
99	DAPK3	0.19476957
100	AURKB	0.18746941

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.54103243
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.10814985
3	Asthma_Homo sapiens_hsa05310	3.35540782
4	Parkinsons disease_Homo sapiens_hsa05012	3.30496565
5	Allograft rejection_Homo sapiens_hsa05330	3.16639058
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.02331032
7	Proteasome_Homo sapiens_hsa03050	2.91941080
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.87278191
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.54702997
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.48615454
11	Alzheimers disease_Homo sapiens_hsa05010	2.16430217
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.13595326
13	Huntingtons disease_Homo sapiens_hsa05016	2.05496946
14	Caffeine metabolism_Homo sapiens_hsa00232	1.84776746
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77833693
16	RNA polymerase_Homo sapiens_hsa03020	1.77051184
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.75693400
18	Protein export_Homo sapiens_hsa03060	1.72520744
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.71750902
20	One carbon pool by folate_Homo sapiens_hsa00670	1.71452561
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.56008998
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.54990001
23	Phototransduction_Homo sapiens_hsa04744	1.49887453
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47781871
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40541869
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38891630
27	Mismatch repair_Homo sapiens_hsa03430	1.37972702
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.34478607
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33078012
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27089771
31	RNA degradation_Homo sapiens_hsa03018	1.20221913
32	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.18170202
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14516252
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.11741655
35	Homologous recombination_Homo sapiens_hsa03440	1.07880324
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07031214
37	Sulfur metabolism_Homo sapiens_hsa00920	1.04054022
38	Viral myocarditis_Homo sapiens_hsa05416	1.03317642
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03161230
40	Basal transcription factors_Homo sapiens_hsa03022	1.02028682
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.00646339
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.99338746
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.96709130
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.96224684
45	DNA replication_Homo sapiens_hsa03030	0.95633153
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92302607
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.89300199
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87928674
49	Purine metabolism_Homo sapiens_hsa00230	0.84799713
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.80364548
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74985467
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70084459
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68750503
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67485028
55	Spliceosome_Homo sapiens_hsa03040	0.67058816
56	Leishmaniasis_Homo sapiens_hsa05140	0.63737937
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62498713
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.60342277
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59979123
60	Metabolic pathways_Homo sapiens_hsa01100	0.58306816
61	Peroxisome_Homo sapiens_hsa04146	0.57892805
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57401152
63	Olfactory transduction_Homo sapiens_hsa04740	0.56038620
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.55974061
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55752569
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55213576
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54273003
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54143190
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54024753
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53548818
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52042189
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51858451
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51544467
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50479872
75	Nicotine addiction_Homo sapiens_hsa05033	0.49803536
76	Propanoate metabolism_Homo sapiens_hsa00640	0.49713154
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46941955
78	RNA transport_Homo sapiens_hsa03013	0.42619137
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41195005
80	Malaria_Homo sapiens_hsa05144	0.41113676
81	Retinol metabolism_Homo sapiens_hsa00830	0.39537197
82	Butanoate metabolism_Homo sapiens_hsa00650	0.38396990
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37965910
84	Base excision repair_Homo sapiens_hsa03410	0.37234292
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37002602
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35334769
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34551517
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.34371876
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34320254
90	Herpes simplex infection_Homo sapiens_hsa05168	0.33855260
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32423523
92	Sulfur relay system_Homo sapiens_hsa04122	0.30236948
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.28313958
94	Measles_Homo sapiens_hsa05162	0.27574977
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.25315503
96	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.24317724
97	Taste transduction_Homo sapiens_hsa04742	0.23973067
98	Morphine addiction_Homo sapiens_hsa05032	0.23942393
99	Mineral absorption_Homo sapiens_hsa04978	0.23634244
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.23414590

RPL23AP43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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