ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.17687419
2	ribosomal small subunit assembly (GO:0000028)	5.22526028
3	nonmotile primary cilium assembly (GO:0035058)	4.83200475
4	proteasome assembly (GO:0043248)	4.46328804
5	fucose catabolic process (GO:0019317)	4.36156264
6	L-fucose metabolic process (GO:0042354)	4.36156264
7	L-fucose catabolic process (GO:0042355)	4.36156264
8	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.19008877
9	ATP synthesis coupled proton transport (GO:0015986)	4.14082854
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.14082854
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.11531077
12	viral transcription (GO:0019083)	4.11227481
13	respiratory chain complex IV assembly (GO:0008535)	4.08496974
14	ribosomal small subunit biogenesis (GO:0042274)	4.07789247
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.93639805
16	S-adenosylmethionine metabolic process (GO:0046500)	3.93298763
17	translational termination (GO:0006415)	3.88776046
18	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.87583596
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83663192
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.82855356
21	translational elongation (GO:0006414)	3.80046936
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.75312877
23	NADH dehydrogenase complex assembly (GO:0010257)	3.75312877
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.75312877
25	cotranslational protein targeting to membrane (GO:0006613)	3.74888733
26	protein targeting to ER (GO:0045047)	3.70206056
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.69668079
28	protein complex biogenesis (GO:0070271)	3.61072999
29	regulation of immunoglobulin secretion (GO:0051023)	3.60308082
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.58883302
31	protein localization to endoplasmic reticulum (GO:0070972)	3.56017524
32	rRNA modification (GO:0000154)	3.55193952
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.52514845
34	response to xenobiotic stimulus (GO:0009410)	3.52246090
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.51059925
36	chaperone-mediated protein transport (GO:0072321)	3.48391973
37	respiratory electron transport chain (GO:0022904)	3.44520018
38	electron transport chain (GO:0022900)	3.41058990
39	maturation of SSU-rRNA (GO:0030490)	3.33962405
40	regulation of cilium movement (GO:0003352)	3.30359040
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30228664
42	regulation of chronic inflammatory response (GO:0002676)	3.29725967
43	cytidine metabolic process (GO:0046087)	3.27099918
44	cytidine catabolic process (GO:0006216)	3.27099918
45	cytidine deamination (GO:0009972)	3.27099918
46	cytochrome complex assembly (GO:0017004)	3.26134393
47	negative regulation of T cell differentiation in thymus (GO:0033085)	3.23618951
48	regulation of regulatory T cell differentiation (GO:0045589)	3.22133202
49	translation (GO:0006412)	3.19293172
50	pseudouridine synthesis (GO:0001522)	3.15357941
51	platelet dense granule organization (GO:0060155)	3.11052046
52	regulation of isotype switching to IgG isotypes (GO:0048302)	3.05124326
53	GTP biosynthetic process (GO:0006183)	3.02566523
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.98264056
55	cellular protein complex disassembly (GO:0043624)	2.98039597
56	cysteine metabolic process (GO:0006534)	2.93678372
57	rRNA processing (GO:0006364)	2.93344764
58	ubiquinone biosynthetic process (GO:0006744)	2.93161539
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.90439999
60	epithelial cilium movement (GO:0003351)	2.89780972
61	rRNA metabolic process (GO:0016072)	2.88290837
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.88112138
63	negative regulation of B cell apoptotic process (GO:0002903)	2.87001372
64	base-excision repair, AP site formation (GO:0006285)	2.85528115
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.85055126
66	ATP biosynthetic process (GO:0006754)	2.83547595
67	rRNA methylation (GO:0031167)	2.83505406
68	viral life cycle (GO:0019058)	2.83044772
69	left/right axis specification (GO:0070986)	2.81857922
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.80915478
71	cell wall macromolecule metabolic process (GO:0044036)	2.80613645
72	cellular component biogenesis (GO:0044085)	2.80272742
73	axoneme assembly (GO:0035082)	2.77242729
74	regulation of cellular amino acid metabolic process (GO:0006521)	2.73090262
75	behavioral response to nicotine (GO:0035095)	2.71814715
76	ribonucleoprotein complex biogenesis (GO:0022613)	2.71650092
77	positive regulation of fatty acid transport (GO:2000193)	2.70394677
78	signal peptide processing (GO:0006465)	2.69352442
79	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68830491
80	regulation of mitotic spindle checkpoint (GO:1903504)	2.68830491
81	somite development (GO:0061053)	2.68437098
82	translational initiation (GO:0006413)	2.68359722
83	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.66112757
84	hydrogen ion transmembrane transport (GO:1902600)	2.61108608
85	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.60777181
86	L-methionine salvage (GO:0071267)	2.59544283
87	L-methionine biosynthetic process (GO:0071265)	2.59544283
88	amino acid salvage (GO:0043102)	2.59544283
89	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.58188945
90	oxidative phosphorylation (GO:0006119)	2.57037985
91	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.55181915
92	pyrimidine nucleotide catabolic process (GO:0006244)	2.54751606
93	protein neddylation (GO:0045116)	2.54358115
94	negative regulation of mast cell activation (GO:0033004)	2.53826922
95	male meiosis I (GO:0007141)	2.53515375
96	interferon-gamma production (GO:0032609)	2.52769624
97	ribosome biogenesis (GO:0042254)	2.51348930
98	protein targeting to membrane (GO:0006612)	2.50548347
99	deoxyribonucleotide catabolic process (GO:0009264)	2.50253547
100	proton transport (GO:0015992)	2.50019056

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.67473734
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75552230
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.65395061
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.33135707
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.21509378
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.16671476
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07021928
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02503266
9	VDR_22108803_ChIP-Seq_LS180_Human	2.77563656
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61764104
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.48073675
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.46151314
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.41548442
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.39995548
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.35443443
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14305896
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09727813
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.06947495
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98538152
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.94860593
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.91352802
22	EWS_26573619_Chip-Seq_HEK293_Human	1.88728537
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.87689184
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86737472
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.83521350
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.79628057
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.73228052
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.65930351
29	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.65358557
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.61337325
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.58881901
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.58647864
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58536423
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.56582325
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54832476
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53974969
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49977449
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47556654
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42041727
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42033260
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.36024422
42	NCOR_22424771_ChIP-Seq_293T_Human	1.35547048
43	AR_20517297_ChIP-Seq_VCAP_Human	1.35349863
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.31534333
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30287973
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30287973
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29666569
48	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29263447
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28345901
50	GATA3_26560356_Chip-Seq_TH2_Human	1.27187506
51	P300_19829295_ChIP-Seq_ESCs_Human	1.26925928
52	MYC_19829295_ChIP-Seq_ESCs_Human	1.26175946
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22223661
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22223661
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21494325
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.21167676
57	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20572994
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19619619
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.19033488
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17897968
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15580911
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13502773
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13307849
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12327405
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11239453
66	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09355163
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09043683
68	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08981854
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08917144
70	FUS_26573619_Chip-Seq_HEK293_Human	1.08606528
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06969595
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.06448640
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.06060668
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06060668
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05975264
76	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05756225
77	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05625428
78	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03612615
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02125917
80	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01960494
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00158614
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99712557
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99230609
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98608344
85	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.98606064
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97931008
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97196697
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.96514864
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.95730902
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95349758
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95042235
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94957844
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94924315
94	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94402177
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93438588
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92707803
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.92692311
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.92227066
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91870032
100	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90822452

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000685_abnormal_immune_system	3.08419576
2	MP0000566_synostosis	3.01252433
3	MP0005671_abnormal_response_to	2.74976786
4	MP0001835_abnormal_antigen_presentation	2.64241163
5	MP0002138_abnormal_hepatobiliary_system	2.37948501
6	MP0002102_abnormal_ear_morphology	2.36332973
7	MP0005646_abnormal_pituitary_gland	2.35557823
8	MP0006292_abnormal_olfactory_placode	2.19584093
9	MP0008789_abnormal_olfactory_epithelium	2.10809238
10	MP0003195_calcinosis	2.07832508
11	MP0009379_abnormal_foot_pigmentation	2.06102978
12	MP0006072_abnormal_retinal_apoptosis	2.05696835
13	MP0003787_abnormal_imprinting	2.02817917
14	MP0003724_increased_susceptibility_to	1.93143079
15	MP0002876_abnormal_thyroid_physiology	1.91248139
16	MP0001764_abnormal_homeostasis	1.83034380
17	MP0001986_abnormal_taste_sensitivity	1.79412081
18	MP0001984_abnormal_olfaction	1.77426355
19	MP0008872_abnormal_physiological_respon	1.77153022
20	MP0004142_abnormal_muscle_tone	1.75813008
21	MP0006276_abnormal_autonomic_nervous	1.70956819
22	MP0003806_abnormal_nucleotide_metabolis	1.70930543
23	MP0008875_abnormal_xenobiotic_pharmacok	1.70211250
24	MP0005551_abnormal_eye_electrophysiolog	1.62971913
25	MP0004145_abnormal_muscle_electrophysio	1.62208221
26	MP0001501_abnormal_sleep_pattern	1.62060290
27	MP0008877_abnormal_DNA_methylation	1.61146729
28	MP0005389_reproductive_system_phenotype	1.56086832
29	MP0003011_delayed_dark_adaptation	1.55826143
30	MP0001919_abnormal_reproductive_system	1.54762357
31	MP0002837_dystrophic_cardiac_calcinosis	1.54217076
32	MP0003123_paternal_imprinting	1.51110568
33	MP0003136_yellow_coat_color	1.44065045
34	MP0005360_urolithiasis	1.43893857
35	MP0001661_extended_life_span	1.40124157
36	MP0003786_premature_aging	1.40110211
37	MP0005085_abnormal_gallbladder_physiolo	1.39363009
38	MP0004147_increased_porphyrin_level	1.38333948
39	MP0004885_abnormal_endolymph	1.37485290
40	MP0009785_altered_susceptibility_to	1.35532368
41	MP0003186_abnormal_redox_activity	1.33948375
42	MP0005408_hypopigmentation	1.31517702
43	MP0002006_tumorigenesis	1.30425972
44	MP0002282_abnormal_trachea_morphology	1.28851535
45	MP0005394_taste/olfaction_phenotype	1.26553197
46	MP0005499_abnormal_olfactory_system	1.26553197
47	MP0002163_abnormal_gland_morphology	1.26501491
48	MP0002736_abnormal_nociception_after	1.26410836
49	MP0006036_abnormal_mitochondrial_physio	1.25540043
50	MP0002234_abnormal_pharynx_morphology	1.23186175
51	MP0005645_abnormal_hypothalamus_physiol	1.22005804
52	MP0001968_abnormal_touch/_nociception	1.21286722
53	MP0001800_abnormal_humoral_immune	1.20534686
54	MP0000631_abnormal_neuroendocrine_gland	1.16691962
55	MP0005000_abnormal_immune_tolerance	1.16554766
56	MP0002148_abnormal_hypersensitivity_rea	1.16310487
57	MP0009333_abnormal_splenocyte_physiolog	1.16042301
58	MP0005253_abnormal_eye_physiology	1.15132763
59	MP0002272_abnormal_nervous_system	1.13492187
60	MP0002166_altered_tumor_susceptibility	1.12117602
61	MP0003718_maternal_effect	1.09597923
62	MP0000613_abnormal_salivary_gland	1.09128734
63	MP0003646_muscle_fatigue	1.07787453
64	MP0005379_endocrine/exocrine_gland_phen	1.07685427
65	MP0005636_abnormal_mineral_homeostasis	1.06529788
66	MP0005410_abnormal_fertilization	1.05831545
67	MP0000049_abnormal_middle_ear	1.05451070
68	MP0000604_amyloidosis	1.04585413
69	MP0001790_abnormal_immune_system	1.03933530
70	MP0005387_immune_system_phenotype	1.03933530
71	MP0002160_abnormal_reproductive_system	1.01536725
72	MP0009764_decreased_sensitivity_to	0.94065389
73	MP0001502_abnormal_circadian_rhythm	0.93537683
74	MP0003878_abnormal_ear_physiology	0.91877468
75	MP0005377_hearing/vestibular/ear_phenot	0.91877468
76	MP0005084_abnormal_gallbladder_morpholo	0.91779132
77	MP0002723_abnormal_immune_serum	0.91409043
78	MP0002405_respiratory_system_inflammati	0.89039045
79	MP0003436_decreased_susceptibility_to	0.87509282
80	MP0003763_abnormal_thymus_physiology	0.85383078
81	MP0002420_abnormal_adaptive_immunity	0.84979901
82	MP0001293_anophthalmia	0.83506878
83	MP0001485_abnormal_pinna_reflex	0.83421899
84	MP0002277_abnormal_respiratory_mucosa	0.83236118
85	MP0002233_abnormal_nose_morphology	0.82923792
86	MP0008995_early_reproductive_senescence	0.81851632
87	MP0001873_stomach_inflammation	0.81497798
88	MP0001819_abnormal_immune_cell	0.80050790
89	MP0005025_abnormal_response_to	0.79365176
90	MP0001963_abnormal_hearing_physiology	0.77789337
91	MP0001929_abnormal_gametogenesis	0.77499470
92	MP0001905_abnormal_dopamine_level	0.77034977
93	MP0010155_abnormal_intestine_physiology	0.76485462
94	MP0002210_abnormal_sex_determination	0.76458487
95	MP0002638_abnormal_pupillary_reflex	0.75578016
96	MP0009745_abnormal_behavioral_response	0.74881157
97	MP0003866_abnormal_defecation	0.73936060
98	MP0002653_abnormal_ependyma_morphology	0.73303823
99	MP0001845_abnormal_inflammatory_respons	0.72037695
100	MP0002452_abnormal_antigen_presenting	0.71959302

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.08251745
2	Abnormality of midbrain morphology (HP:0002418)	3.98249209
3	Molar tooth sign on MRI (HP:0002419)	3.98249209
4	Mitochondrial inheritance (HP:0001427)	3.83786566
5	Hypomagnesemia (HP:0002917)	3.63010120
6	Stomatitis (HP:0010280)	3.53372586
7	Hepatocellular necrosis (HP:0001404)	3.49933064
8	Pancreatic cysts (HP:0001737)	3.47135802
9	Progressive macrocephaly (HP:0004481)	3.42701432
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.42694655
11	Increased CSF lactate (HP:0002490)	3.40865570
12	True hermaphroditism (HP:0010459)	3.40331464
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38259985
14	Hepatic necrosis (HP:0002605)	3.37362602
15	Acute encephalopathy (HP:0006846)	3.36423663
16	Abnormality of magnesium homeostasis (HP:0004921)	3.28364594
17	Attenuation of retinal blood vessels (HP:0007843)	3.21973546
18	Abnormality of the labia minora (HP:0012880)	3.16090416
19	Pancreatic fibrosis (HP:0100732)	3.15772881
20	Congenital stationary night blindness (HP:0007642)	3.15000987
21	Medial flaring of the eyebrow (HP:0010747)	3.09625820
22	Cerebral edema (HP:0002181)	3.03498964
23	Type II lissencephaly (HP:0007260)	2.86571525
24	Congenital primary aphakia (HP:0007707)	2.84119754
25	Increased hepatocellular lipid droplets (HP:0006565)	2.80749676
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.78570764
27	Optic disc pallor (HP:0000543)	2.75201239
28	Gait imbalance (HP:0002141)	2.73722011
29	Increased serum lactate (HP:0002151)	2.58910419
30	Nephrogenic diabetes insipidus (HP:0009806)	2.58513002
31	IgG deficiency (HP:0004315)	2.53637685
32	Lipid accumulation in hepatocytes (HP:0006561)	2.49175580
33	Rhinitis (HP:0012384)	2.36000363
34	Increased IgM level (HP:0003496)	2.34631463
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.33003634
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31752192
37	Vaginal atresia (HP:0000148)	2.31401286
38	Renal Fanconi syndrome (HP:0001994)	2.29730225
39	Decreased central vision (HP:0007663)	2.26610939
40	Abnormality of T cell physiology (HP:0011840)	2.25495007
41	Genital tract atresia (HP:0001827)	2.24422711
42	Abnormality of the middle phalanges of the toes (HP:0010183)	2.23308217
43	Retinal dysplasia (HP:0007973)	2.22149705
44	Severe combined immunodeficiency (HP:0004430)	2.21005282
45	Abnormality of the prostate (HP:0008775)	2.18494605
46	Hyperglycinemia (HP:0002154)	2.17153548
47	Lactic acidosis (HP:0003128)	2.15486314
48	Abnormality of T cells (HP:0002843)	2.14734713
49	Abnormal number of erythroid precursors (HP:0012131)	2.14328595
50	Cystic liver disease (HP:0006706)	2.14155852
51	Congenital, generalized hypertrichosis (HP:0004540)	2.12984667
52	Prostate neoplasm (HP:0100787)	2.12784618
53	Reticulocytopenia (HP:0001896)	2.11677967
54	Supernumerary spleens (HP:0009799)	2.11387455
55	Abnormal respiratory motile cilium physiology (HP:0012261)	2.11128482
56	Constricted visual fields (HP:0001133)	2.10784402
57	Abnormality of the renal cortex (HP:0011035)	2.06023977
58	Chronic otitis media (HP:0000389)	2.05602487
59	Polyuria (HP:0000103)	2.05478132
60	Chronic sinusitis (HP:0011109)	2.04115447
61	Respiratory failure (HP:0002878)	2.02070827
62	Abnormal drinking behavior (HP:0030082)	1.98945447
63	Polydipsia (HP:0001959)	1.98945447
64	Large for gestational age (HP:0001520)	1.98560403
65	Macrocytic anemia (HP:0001972)	1.97587590
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.96763786
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.96682572
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.96682572
69	Increased intramyocellular lipid droplets (HP:0012240)	1.95164320
70	Lethargy (HP:0001254)	1.94625854
71	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.93946193
72	Asplenia (HP:0001746)	1.93023946
73	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.92902579
74	Poor coordination (HP:0002370)	1.92754615
75	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.91011818
76	Stenosis of the external auditory canal (HP:0000402)	1.90876133
77	Rib fusion (HP:0000902)	1.88262656
78	Sclerocornea (HP:0000647)	1.87333035
79	Cerebellar dysplasia (HP:0007033)	1.86894654
80	Anencephaly (HP:0002323)	1.85760500
81	Abolished electroretinogram (ERG) (HP:0000550)	1.85580315
82	Bronchiectasis (HP:0002110)	1.84041400
83	Occipital encephalocele (HP:0002085)	1.84013451
84	3-Methylglutaconic aciduria (HP:0003535)	1.82230557
85	Humeroradial synostosis (HP:0003041)	1.81901189
86	Synostosis involving the elbow (HP:0003938)	1.81901189
87	Type 2 muscle fiber atrophy (HP:0003554)	1.80892720
88	Exercise intolerance (HP:0003546)	1.80496884
89	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79050002
90	Fused cervical vertebrae (HP:0002949)	1.78202733
91	Pendular nystagmus (HP:0012043)	1.77734270
92	Methylmalonic acidemia (HP:0002912)	1.76993698
93	Generalized aminoaciduria (HP:0002909)	1.76209660
94	Exertional dyspnea (HP:0002875)	1.75168983
95	Tetany (HP:0001281)	1.75128663
96	Alkalosis (HP:0001948)	1.73605277
97	Abnormal ciliary motility (HP:0012262)	1.71500527
98	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.70759192
99	Ketoacidosis (HP:0001993)	1.70225776
100	Abnormal urine output (HP:0012590)	1.69020269

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.20047584
2	ZAK	4.90037080
3	NUAK1	2.76570640
4	VRK2	2.70352054
5	TAOK3	2.45985655
6	BCKDK	2.28719504
7	ADRBK2	2.27928041
8	VRK1	2.21161915
9	MST4	2.17012114
10	PINK1	2.05865293
11	GRK1	1.98597885
12	NME1	1.97507897
13	PASK	1.95494857
14	MAP4K1	1.93199826
15	MAP4K2	1.90069351
16	DYRK2	1.79209438
17	PLK4	1.78889870
18	MAP3K12	1.52132238
19	TNK2	1.50516402
20	WNK3	1.50282297
21	CASK	1.42022067
22	BUB1	1.40480055
23	FRK	1.40433630
24	WNK4	1.34720336
25	MAPKAPK3	1.33676834
26	NME2	1.32358774
27	TIE1	1.26456724
28	KDR	1.21406002
29	PHKG2	1.17381599
30	PHKG1	1.17381599
31	CDC7	1.15181845
32	MAPKAPK5	1.13564259
33	CCNB1	1.12607013
34	TXK	1.06668803
35	DAPK1	1.02609681
36	TEC	0.98948280
37	STK39	0.98926026
38	CSNK1G3	0.96131688
39	OXSR1	0.95699039
40	KIT	0.95360204
41	ITK	0.94719198
42	CSNK1A1L	0.91623180
43	EIF2AK2	0.91508054
44	RPS6KA5	0.90035626
45	CSNK1G1	0.89385133
46	SYK	0.85775409
47	CDK8	0.84790348
48	HIPK2	0.83740116
49	PLK3	0.83486728
50	PLK2	0.83082190
51	PRKCQ	0.82934109
52	CAMKK2	0.80612569
53	PIM1	0.79239750
54	CSF1R	0.78907252
55	ADRBK1	0.78077743
56	FGFR2	0.75967191
57	CSNK1G2	0.75955166
58	LRRK2	0.75182710
59	MAP2K6	0.75073985
60	BMPR1B	0.72677005
61	STK16	0.70234504
62	INSRR	0.69970773
63	LIMK1	0.67340032
64	SRPK1	0.65148174
65	PRKCI	0.64073492
66	STK38L	0.63649199
67	IKBKB	0.63312304
68	NEK1	0.62881878
69	AURKA	0.62496886
70	TAF1	0.61072113
71	MELK	0.60849426
72	FES	0.60311516
73	NEK9	0.59589969
74	ZAP70	0.58917413
75	PLK1	0.58575484
76	RPS6KA4	0.58380339
77	AURKB	0.56731377
78	TNIK	0.56181825
79	MKNK1	0.55916493
80	TRIM28	0.55362666
81	PIK3CA	0.54054186
82	PIM2	0.51866236
83	PRKCG	0.49072139
84	ATR	0.46834396
85	WEE1	0.45854167
86	LYN	0.45439640
87	GRK6	0.45181329
88	DAPK3	0.45141606
89	EIF2AK3	0.44907480
90	CAMKK1	0.43450030
91	EIF2AK1	0.42663515
92	MARK3	0.42194799
93	EPHB2	0.41558445
94	OBSCN	0.39463245
95	PRKACA	0.38452013
96	CSNK2A1	0.37316609
97	GRK7	0.37257977
98	MAP3K5	0.37138576
99	TGFBR1	0.36228423
100	NTRK2	0.33656061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.93962673
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19200858
3	Proteasome_Homo sapiens_hsa03050	3.09841593
4	Asthma_Homo sapiens_hsa05310	3.06535583
5	Parkinsons disease_Homo sapiens_hsa05012	2.69376182
6	Protein export_Homo sapiens_hsa03060	2.60222994
7	Allograft rejection_Homo sapiens_hsa05330	2.45729111
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.42357881
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31155332
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.25060669
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12861802
12	One carbon pool by folate_Homo sapiens_hsa00670	1.98660365
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.95201630
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.88409497
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.85319301
16	Huntingtons disease_Homo sapiens_hsa05016	1.80219421
17	Phototransduction_Homo sapiens_hsa04744	1.74596541
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.74430346
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68850706
20	Alzheimers disease_Homo sapiens_hsa05010	1.67811771
21	RNA degradation_Homo sapiens_hsa03018	1.66378878
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66284155
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65817636
24	Basal transcription factors_Homo sapiens_hsa03022	1.65287767
25	RNA polymerase_Homo sapiens_hsa03020	1.58813661
26	Homologous recombination_Homo sapiens_hsa03440	1.51492914
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.49608983
28	Mismatch repair_Homo sapiens_hsa03430	1.42372466
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41553297
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39290229
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34107570
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32862080
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.32289225
34	DNA replication_Homo sapiens_hsa03030	1.29691717
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.26957447
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.26450814
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15218952
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11306087
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06725774
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01895109
41	Sulfur relay system_Homo sapiens_hsa04122	0.99040870
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96972184
43	Purine metabolism_Homo sapiens_hsa00230	0.95974482
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95741169
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.95414392
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95063565
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92678783
48	Propanoate metabolism_Homo sapiens_hsa00640	0.92269125
49	Regulation of autophagy_Homo sapiens_hsa04140	0.91725298
50	Folate biosynthesis_Homo sapiens_hsa00790	0.91488381
51	Caffeine metabolism_Homo sapiens_hsa00232	0.90783244
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90118158
53	Peroxisome_Homo sapiens_hsa04146	0.89890826
54	Base excision repair_Homo sapiens_hsa03410	0.88205018
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88136038
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.87298954
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84995517
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82340573
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82105748
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80664767
61	Mineral absorption_Homo sapiens_hsa04978	0.78097275
62	Butanoate metabolism_Homo sapiens_hsa00650	0.73058550
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.72900814
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.70065146
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69367910
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68440505
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68100594
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.67351513
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66062280
70	Viral myocarditis_Homo sapiens_hsa05416	0.64930283
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.64625842
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64261664
73	Sulfur metabolism_Homo sapiens_hsa00920	0.62895262
74	Metabolic pathways_Homo sapiens_hsa01100	0.61447365
75	Spliceosome_Homo sapiens_hsa03040	0.60344195
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60007325
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58819316
78	Retinol metabolism_Homo sapiens_hsa00830	0.58464702
79	RNA transport_Homo sapiens_hsa03013	0.56448542
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56400177
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55766982
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53935875
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51781436
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.50117883
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.48426404
86	Olfactory transduction_Homo sapiens_hsa04740	0.47939987
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45393753
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40755501
89	Fatty acid degradation_Homo sapiens_hsa00071	0.39023153
90	p53 signaling pathway_Homo sapiens_hsa04115	0.39013398
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38036372
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36554142
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35300172
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32594563
95	Glutathione metabolism_Homo sapiens_hsa00480	0.31428177
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28516000
97	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26995127
98	Fatty acid elongation_Homo sapiens_hsa00062	0.26524160
99	Malaria_Homo sapiens_hsa05144	0.26407848
100	Histidine metabolism_Homo sapiens_hsa00340	0.26179980

RPL23AP44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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