ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	7.23370754
2	DNA methylation involved in gamete generation (GO:0043046)	6.06286051
3	chromosome organization involved in meiosis (GO:0070192)	5.63114922
4	male meiosis I (GO:0007141)	5.52757499
5	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.19385099
6	male meiosis (GO:0007140)	5.13986640
7	histone H3-K9 demethylation (GO:0033169)	5.13271662
8	piRNA metabolic process (GO:0034587)	5.06023456
9	positive regulation of histone H3-K4 methylation (GO:0051571)	5.00613591
10	regulation of histone H3-K4 methylation (GO:0051569)	4.87706902
11	nuclear pore complex assembly (GO:0051292)	4.85361491
12	nuclear pore organization (GO:0006999)	4.84865876
13	diterpenoid biosynthetic process (GO:0016102)	4.77420716
14	protein refolding (GO:0042026)	4.74712467
15	meiosis I (GO:0007127)	4.72679584
16	synaptonemal complex assembly (GO:0007130)	4.63120866
17	regulation of meiosis I (GO:0060631)	4.59367374
18	DNA replication initiation (GO:0006270)	4.47305900
19	DNA synthesis involved in DNA repair (GO:0000731)	4.42912597
20	resolution of meiotic recombination intermediates (GO:0000712)	4.37553238
21	meiotic chromosome segregation (GO:0045132)	4.33092667
22	regulation of histone H3-K9 methylation (GO:0051570)	4.30081815
23	synaptonemal complex organization (GO:0070193)	4.30026740
24	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.29596610
25	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.28982631
26	negative regulation of inclusion body assembly (GO:0090084)	4.24715965
27	DNA replication checkpoint (GO:0000076)	4.07935692
28	positive regulation of histone methylation (GO:0031062)	4.03136223
29	terpenoid biosynthetic process (GO:0016114)	3.93805769
30	gas transport (GO:0015669)	3.90682781
31	meiotic nuclear division (GO:0007126)	3.90155223
32	proteasome assembly (GO:0043248)	3.81617041
33	regulation of histone methylation (GO:0031060)	3.77949286
34	oxygen transport (GO:0015671)	3.77202561
35	pore complex assembly (GO:0046931)	3.76613738
36	phosphorelay signal transduction system (GO:0000160)	3.71241154
37	mitotic nuclear envelope disassembly (GO:0007077)	3.71218010
38	protoporphyrinogen IX metabolic process (GO:0046501)	3.62594960
39	oxidative phosphorylation (GO:0006119)	3.55910369
40	meiotic cell cycle process (GO:1903046)	3.55626196
41	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.48296145
42	membrane disassembly (GO:0030397)	3.46011737
43	nuclear envelope disassembly (GO:0051081)	3.46011737
44	negative regulation of histone methylation (GO:0031061)	3.44358196
45	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.40250997
46	regulation of translational fidelity (GO:0006450)	3.39173866
47	intra-S DNA damage checkpoint (GO:0031573)	3.38108220
48	purine nucleobase biosynthetic process (GO:0009113)	3.35080097
49	tRNA aminoacylation for protein translation (GO:0006418)	3.34156969
50	erythrocyte development (GO:0048821)	3.32493347
51	formation of translation preinitiation complex (GO:0001731)	3.29979403
52	gene silencing by RNA (GO:0031047)	3.26854987
53	mismatch repair (GO:0006298)	3.20231722
54	amino acid activation (GO:0043038)	3.17496233
55	tRNA aminoacylation (GO:0043039)	3.17496233
56	DNA strand elongation (GO:0022616)	3.16516042
57	vitamin A metabolic process (GO:0006776)	3.13127365
58	IMP biosynthetic process (GO:0006188)	3.12804692
59	DNA strand elongation involved in DNA replication (GO:0006271)	3.11315579
60	regulation of RNA export from nucleus (GO:0046831)	3.09870737
61	regulation of histone H3-K27 methylation (GO:0061085)	3.07807818
62	telomere maintenance via semi-conservative replication (GO:0032201)	3.02135983
63	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.01170237
64	mitotic chromosome condensation (GO:0007076)	3.00793874
65	meiotic cell cycle (GO:0051321)	2.97780584
66	DNA methylation (GO:0006306)	2.96330606
67	DNA alkylation (GO:0006305)	2.96330606
68	organelle membrane fusion (GO:0090174)	2.92261846
69	DNA catabolic process, exonucleolytic (GO:0000738)	2.92030767
70	mitotic sister chromatid segregation (GO:0000070)	2.88894136
71	protein K6-linked ubiquitination (GO:0085020)	2.88275949
72	negative regulation of protein acetylation (GO:1901984)	2.85259388
73	centriole replication (GO:0007099)	2.84237875
74	mitochondrial RNA metabolic process (GO:0000959)	2.80830760
75	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.80765490
76	negative regulation of mast cell activation (GO:0033004)	2.80703981
77	negative regulation of histone modification (GO:0031057)	2.76493595
78	chromosome segregation (GO:0007059)	2.76264937
79	autophagic vacuole fusion (GO:0000046)	2.75608454
80	DNA packaging (GO:0006323)	2.69810006
81	proline biosynthetic process (GO:0006561)	2.68950613
82	regulation of gene expression by genetic imprinting (GO:0006349)	2.68611789
83	nucleobase biosynthetic process (GO:0046112)	2.68601053
84	ribosome biogenesis (GO:0042254)	2.68214008
85	postreplication repair (GO:0006301)	2.67332247
86	sister chromatid segregation (GO:0000819)	2.67015649
87	centriole assembly (GO:0098534)	2.66536639
88	maturation of 5.8S rRNA (GO:0000460)	2.66427071
89	sensory perception of smell (GO:0007608)	2.66385427
90	DNA unwinding involved in DNA replication (GO:0006268)	2.66006179
91	histone demethylation (GO:0016577)	2.65860111
92	reciprocal DNA recombination (GO:0035825)	2.63513566
93	reciprocal meiotic recombination (GO:0007131)	2.63513566
94	telomere maintenance via recombination (GO:0000722)	2.61170744
95	IMP metabolic process (GO:0046040)	2.60165218
96	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.60070643
97	protein dealkylation (GO:0008214)	2.59975141
98	protein demethylation (GO:0006482)	2.59975141
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59248012
100	termination of RNA polymerase III transcription (GO:0006386)	2.59248012

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.37136456
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68826780
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.66321196
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.32266259
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.01721547
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.98572578
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93179779
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88452981
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.84330734
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75085348
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.70096322
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56318907
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.42049448
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.41648403
15	NCOR1_26117541_ChIP-Seq_K562_Human	2.41459769
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.37122326
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.31680905
18	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.24053128
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.19469776
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13413301
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.13315619
22	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.12631538
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10441545
24	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.08614983
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08407005
26	GATA1_19941826_ChIP-Seq_K562_Human	2.05452983
27	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.01012233
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.98049234
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.97936511
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.95329081
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92667707
32	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.88714092
33	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.85423628
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.84647146
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84017678
36	VDR_22108803_ChIP-Seq_LS180_Human	1.81526893
37	KDM5A_27292631_Chip-Seq_BREAST_Human	1.81403539
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.78875306
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.76098862
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.75184585
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.74895894
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69667759
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.69149945
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.67431527
45	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.60592106
46	TFEB_21752829_ChIP-Seq_HELA_Human	1.58475326
47	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.56427191
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.56256708
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54518128
50	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.54395319
51	ZNF263_19887448_ChIP-Seq_K562_Human	1.53934951
52	SPI1_23127762_ChIP-Seq_K562_Human	1.51766571
53	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.45798100
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45042252
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.44996174
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.43588001
57	GATA2_19941826_ChIP-Seq_K562_Human	1.43271957
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40224381
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39247452
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.35165876
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.33161633
62	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.32872398
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.32226117
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29292274
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27419541
66	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.27178451
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25147308
68	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24426542
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23166574
70	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23045961
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20581802
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.09286444
73	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.06705062
74	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.05333235
75	AR_21909140_ChIP-Seq_LNCAP_Human	1.04823497
76	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.03351585
77	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00673520
78	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.99917134
79	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.98467308
80	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.91722797
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91491606
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90759436
83	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.90586667
84	SPI1_23547873_ChIP-Seq_NB4_Human	0.90107788
85	GATA1_22025678_ChIP-Seq_K562_Human	0.89950113
86	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.86506645
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85569388
88	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85104997
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85096398
90	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.83872770
91	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.81605642
92	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.81592229
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.81428572
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.81009975
95	SCL_19346495_ChIP-Seq_HPC-7_Human	0.80804467
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.80718056
97	GATA3_26560356_Chip-Seq_TH1_Human	0.79735673
98	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78809018
99	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.78508435
100	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.76817457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.91115296
2	MP0008995_early_reproductive_senescence	4.09766343
3	MP0008058_abnormal_DNA_repair	3.98216148
4	MP0008057_abnormal_DNA_replication	3.56242488
5	MP0004147_increased_porphyrin_level	3.43839176
6	MP0003693_abnormal_embryo_hatching	3.22620857
7	MP0003718_maternal_effect	3.06049442
8	MP0000678_abnormal_parathyroid_gland	2.94421162
9	MP0004957_abnormal_blastocyst_morpholog	2.78797328
10	MP0002822_catalepsy	2.73855615
11	MP0010094_abnormal_chromosome_stability	2.72851204
12	MP0003111_abnormal_nucleus_morphology	2.63107057
13	MP0005451_abnormal_body_composition	2.63039214
14	MP0002210_abnormal_sex_determination	2.46477670
15	MP0003786_premature_aging	2.45999343
16	MP0001929_abnormal_gametogenesis	2.41782924
17	MP0006035_abnormal_mitochondrial_morpho	2.38394365
18	MP0003077_abnormal_cell_cycle	2.34711045
19	MP0002132_abnormal_respiratory_system	2.34327677
20	MP0002160_abnormal_reproductive_system	2.28885924
21	MP0003646_muscle_fatigue	2.18954649
22	MP0005083_abnormal_biliary_tract	2.09547643
23	MP0003806_abnormal_nucleotide_metabolis	1.82589405
24	MP0003186_abnormal_redox_activity	1.78494330
25	MP0006036_abnormal_mitochondrial_physio	1.78394545
26	MP0006292_abnormal_olfactory_placode	1.77276761
27	MP0005410_abnormal_fertilization	1.74002454
28	MP0001730_embryonic_growth_arrest	1.73783235
29	MP0003698_abnormal_male_reproductive	1.72835218
30	MP0008932_abnormal_embryonic_tissue	1.70629239
31	MP0003890_abnormal_embryonic-extraembry	1.68322991
32	MP0003221_abnormal_cardiomyocyte_apopto	1.66924042
33	MP0003656_abnormal_erythrocyte_physiolo	1.66499154
34	MP0004233_abnormal_muscle_weight	1.66021875
35	MP0000653_abnormal_sex_gland	1.63365623
36	MP0001145_abnormal_male_reproductive	1.61035757
37	MP0005389_reproductive_system_phenotype	1.43486012
38	MP0000350_abnormal_cell_proliferation	1.39271663
39	MP0008007_abnormal_cellular_replicative	1.37654011
40	MP0003699_abnormal_female_reproductive	1.37037031
41	MP0000703_abnormal_thymus_morphology	1.36075743
42	MP0005397_hematopoietic_system_phenotyp	1.32086935
43	MP0001545_abnormal_hematopoietic_system	1.32086935
44	MP0001697_abnormal_embryo_size	1.29525800
45	MP0009697_abnormal_copulation	1.29287583
46	MP0002161_abnormal_fertility/fecundity	1.27597033
47	MP0000313_abnormal_cell_death	1.19366356
48	MP0000358_abnormal_cell_content/	1.14757206
49	MP0001764_abnormal_homeostasis	1.13521272
50	MP0002080_prenatal_lethality	1.09081931
51	MP0009840_abnormal_foam_cell	1.05713288
52	MP0005380_embryogenesis_phenotype	1.04582708
53	MP0001672_abnormal_embryogenesis/_devel	1.04582708
54	MP0004808_abnormal_hematopoietic_stem	1.03391879
55	MP0001119_abnormal_female_reproductive	1.02886688
56	MP0005645_abnormal_hypothalamus_physiol	1.01383399
57	MP0003959_abnormal_lean_body	1.00823269
58	MP0001661_extended_life_span	0.99887743
59	MP0000749_muscle_degeneration	0.99623221
60	MP0000372_irregular_coat_pigmentation	0.96129532
61	MP0002102_abnormal_ear_morphology	0.95431268
62	MP0002086_abnormal_extraembryonic_tissu	0.92107231
63	MP0004019_abnormal_vitamin_homeostasis	0.89028440
64	MP0003984_embryonic_growth_retardation	0.86522243
65	MP0002088_abnormal_embryonic_growth/wei	0.83618077
66	MP0002722_abnormal_immune_system	0.82893611
67	MP0003828_pulmonary_edema	0.82038775
68	MP0002139_abnormal_hepatobiliary_system	0.81249817
69	MP0002970_abnormal_white_adipose	0.80480713
70	MP0000689_abnormal_spleen_morphology	0.77507342
71	MP0002084_abnormal_developmental_patter	0.76548815
72	MP0008789_abnormal_olfactory_epithelium	0.76354928
73	MP0005636_abnormal_mineral_homeostasis	0.74746423
74	MP0005535_abnormal_body_temperature	0.74008523
75	MP0002398_abnormal_bone_marrow	0.73542426
76	MP0001529_abnormal_vocalization	0.73459146
77	MP0002019_abnormal_tumor_incidence	0.72652880
78	MP0005395_other_phenotype	0.72296684
79	MP0002735_abnormal_chemical_nociception	0.71978548
80	MP0000613_abnormal_salivary_gland	0.71206974
81	MP0001502_abnormal_circadian_rhythm	0.70901875
82	MP0004145_abnormal_muscle_electrophysio	0.69674644
83	MP0000427_abnormal_hair_cycle	0.69232513
84	MP0004142_abnormal_muscle_tone	0.68509371
85	MP0005452_abnormal_adipose_tissue	0.64964322
86	MP0000681_abnormal_thyroid_gland	0.64618070
87	MP0010307_abnormal_tumor_latency	0.63994301
88	MP0000015_abnormal_ear_pigmentation	0.63660697
89	MP0005384_cellular_phenotype	0.63123679
90	MP0003172_abnormal_lysosome_physiology	0.62898447
91	MP0002085_abnormal_embryonic_tissue	0.62528076
92	MP0008770_decreased_survivor_rate	0.62178622
93	MP0005408_hypopigmentation	0.60384331
94	MP0004742_abnormal_vestibular_system	0.58744778
95	MP0005334_abnormal_fat_pad	0.56098930
96	MP0005394_taste/olfaction_phenotype	0.55665103
97	MP0005499_abnormal_olfactory_system	0.55665103
98	MP0001919_abnormal_reproductive_system	0.55278713
99	MP0000631_abnormal_neuroendocrine_gland	0.54903504
100	MP0002269_muscular_atrophy	0.54082207

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	6.48104255
2	Cholecystitis (HP:0001082)	6.48104255
3	Truncus arteriosus (HP:0001660)	5.44660448
4	Increased serum pyruvate (HP:0003542)	4.26630680
5	Reticulocytosis (HP:0001923)	4.24538325
6	Abnormality of glycolysis (HP:0004366)	4.14243363
7	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.07729522
8	Bowel incontinence (HP:0002607)	3.93743387
9	Upper limb muscle weakness (HP:0003484)	3.88919006
10	Abnormal large intestine physiology (HP:0012700)	3.80039574
11	Ankyloglossia (HP:0010296)	3.76358031
12	Diaphragmatic weakness (HP:0009113)	3.73023152
13	Homocystinuria (HP:0002156)	3.68122234
14	Abnormality of homocysteine metabolism (HP:0010919)	3.68122234
15	Polycythemia (HP:0001901)	3.64891108
16	Abnormal hemoglobin (HP:0011902)	3.60642401
17	Hyperthyroidism (HP:0000836)	3.53794588
18	Abnormality of reticulocytes (HP:0004312)	3.29602378
19	Type I transferrin isoform profile (HP:0003642)	3.10041286
20	Cholelithiasis (HP:0001081)	2.96430254
21	Hypertensive crisis (HP:0100735)	2.95361256
22	Ileus (HP:0002595)	2.94186800
23	Abnormal gallbladder morphology (HP:0012437)	2.88324505
24	Microvesicular hepatic steatosis (HP:0001414)	2.87920324
25	Shoulder girdle muscle weakness (HP:0003547)	2.84409350
26	Chromsome breakage (HP:0040012)	2.78913456
27	Acute encephalopathy (HP:0006846)	2.78390860
28	Stomatitis (HP:0010280)	2.78197503
29	Premature ovarian failure (HP:0008209)	2.66454448
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.65447557
31	Acute necrotizing encephalopathy (HP:0006965)	2.60199949
32	Hyperbilirubinemia (HP:0002904)	2.60003977
33	Poikilocytosis (HP:0004447)	2.59812767
34	Abnormality of cochlea (HP:0000375)	2.55073905
35	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.50366501
36	Abnormality of the gallbladder (HP:0005264)	2.48856547
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46408517
38	Abnormality of alanine metabolism (HP:0010916)	2.46408517
39	Hyperalaninemia (HP:0003348)	2.46408517
40	Rimmed vacuoles (HP:0003805)	2.45781045
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38073806
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38073806
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36725021
44	Abnormality of oral frenula (HP:0000190)	2.36415545
45	Cortical dysplasia (HP:0002539)	2.34550708
46	Abnormality of the anterior horn cell (HP:0006802)	2.31731841
47	Degeneration of anterior horn cells (HP:0002398)	2.31731841
48	Birth length less than 3rd percentile (HP:0003561)	2.30804216
49	Limb hypertonia (HP:0002509)	2.26838081
50	Hypoparathyroidism (HP:0000829)	2.25527633
51	Tinnitus (HP:0000360)	2.24927124
52	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.23318847
53	Increased serum lactate (HP:0002151)	2.16337961
54	Methylmalonic acidemia (HP:0002912)	2.15957526
55	Abnormal protein glycosylation (HP:0012346)	2.13627803
56	Abnormal glycosylation (HP:0012345)	2.13627803
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.13627803
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.13627803
59	Pallor (HP:0000980)	2.08567077
60	Seborrheic dermatitis (HP:0001051)	2.06869785
61	Ventricular fibrillation (HP:0001663)	2.06553512
62	Acanthocytosis (HP:0001927)	2.03762168
63	Severe visual impairment (HP:0001141)	2.03718902
64	Progressive macrocephaly (HP:0004481)	2.03331241
65	Atelectasis (HP:0100750)	2.03315321
66	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.02893542
67	Increased CSF lactate (HP:0002490)	2.02665012
68	Increased nuchal translucency (HP:0010880)	1.99762964
69	Oligodactyly (hands) (HP:0001180)	1.94627959
70	Acute myeloid leukemia (HP:0004808)	1.93648869
71	Duplicated collecting system (HP:0000081)	1.93200905
72	Spinal muscular atrophy (HP:0007269)	1.91943310
73	Abnormality of methionine metabolism (HP:0010901)	1.89412922
74	Easy fatigability (HP:0003388)	1.88897901
75	Respiratory difficulties (HP:0002880)	1.88597906
76	3-Methylglutaconic aciduria (HP:0003535)	1.88410005
77	Abnormality of DNA repair (HP:0003254)	1.88329634
78	Small intestinal stenosis (HP:0012848)	1.86841776
79	Duodenal stenosis (HP:0100867)	1.86841776
80	Morphological abnormality of the inner ear (HP:0011390)	1.84448875
81	Cerebral hemorrhage (HP:0001342)	1.83618754
82	Abnormality of the tricuspid valve (HP:0001702)	1.82467341
83	Mutism (HP:0002300)	1.81490273
84	Secondary amenorrhea (HP:0000869)	1.78775983
85	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.78756422
86	Adenoma sebaceum (HP:0009720)	1.78193201
87	Angiofibromas (HP:0010615)	1.78193201
88	Cerebral edema (HP:0002181)	1.77965621
89	Papillary thyroid carcinoma (HP:0002895)	1.77922215
90	Progressive inability to walk (HP:0002505)	1.76827683
91	Lactic acidosis (HP:0003128)	1.76286655
92	Myelodysplasia (HP:0002863)	1.75985350
93	Azoospermia (HP:0000027)	1.70112153
94	Volvulus (HP:0002580)	1.67175105
95	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.66545630
96	Meningioma (HP:0002858)	1.66178010
97	Mitochondrial inheritance (HP:0001427)	1.65764090
98	Abnormality of the renal collecting system (HP:0004742)	1.65731267
99	Gonadotropin excess (HP:0000837)	1.64810219
100	Sandal gap (HP:0001852)	1.64686460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.39492128
2	MAPKAPK5	4.06219380
3	RIPK4	3.65620323
4	KSR2	3.09025822
5	CLK1	2.93882008
6	PDK2	2.93770654
7	TTK	2.64972176
8	PNCK	2.61326963
9	RAF1	2.28006498
10	EIF2AK3	2.24873909
11	KSR1	2.15526657
12	TSSK6	2.09657429
13	CASK	2.08761482
14	TYRO3	2.03606305
15	PLK4	2.02203367
16	TEC	1.93902403
17	NTRK3	1.82018787
18	NEK1	1.81610751
19	MAP3K2	1.78618954
20	SIK2	1.73753281
21	BMX	1.72843888
22	MST4	1.64932903
23	CCNB1	1.60527935
24	CDK19	1.60506745
25	BMPR2	1.53693904
26	PTK2B	1.51251926
27	WEE1	1.47899582
28	CAMK1G	1.43352096
29	CDC7	1.42656790
30	BUB1	1.42289643
31	NME1	1.38985564
32	FGR	1.35925349
33	MAP3K4	1.29331621
34	MAP3K8	1.22458207
35	ATR	1.19950669
36	WNK1	1.19877116
37	CDK12	1.17480596
38	SRPK1	1.11853557
39	MET	1.11573280
40	VRK1	1.11213105
41	TAOK2	1.09062761
42	PRPF4B	1.08035192
43	CHEK2	1.04705906
44	NEK2	1.02191927
45	EEF2K	1.01805614
46	IRAK3	1.00179618
47	RET	0.98325509
48	PBK	0.95218835
49	PASK	0.94228816
50	MATK	0.93543480
51	CHEK1	0.92741929
52	BRAF	0.89972680
53	TAOK3	0.87327419
54	PLK2	0.86994023
55	JAK2	0.86894503
56	BTK	0.79258177
57	TNIK	0.78267070
58	YES1	0.75591503
59	ATM	0.71761727
60	PLK3	0.71567344
61	CAMK1D	0.71403142
62	RPS6KB2	0.70240485
63	CDK1	0.68550555
64	ITK	0.67965867
65	MAPKAPK3	0.64025494
66	RPS6KB1	0.63214987
67	WNK4	0.62084584
68	CDK2	0.57709160
69	AURKA	0.56692530
70	PLK1	0.56162815
71	CSNK2A2	0.55991306
72	MTOR	0.54720757
73	CSNK1E	0.53179039
74	ARAF	0.50707817
75	BCKDK	0.49960860
76	PRKCI	0.47921104
77	MAP2K3	0.46966577
78	NUAK1	0.46960152
79	MAP2K6	0.45179304
80	MAP3K13	0.44921530
81	RPS6KA5	0.41551313
82	MARK3	0.41038377
83	HCK	0.39573181
84	CDK7	0.38189729
85	STK3	0.37989019
86	BRSK2	0.36615816
87	NEK6	0.35113664
88	SGK1	0.34984959
89	PRKACG	0.34361363
90	SIK3	0.34138993
91	TRPM7	0.31552214
92	MAPK10	0.31410908
93	PINK1	0.29875724
94	CSNK2A1	0.28853036
95	CDK11A	0.28283048
96	MAP3K6	0.27769397
97	GSK3B	0.26787505
98	MAP2K1	0.26485817
99	IKBKB	0.25348149
100	PAK1	0.25055474

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.98307813
2	Mismatch repair_Homo sapiens_hsa03430	3.67115744
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.62196553
4	RNA transport_Homo sapiens_hsa03013	3.07899293
5	DNA replication_Homo sapiens_hsa03030	3.02426965
6	Homologous recombination_Homo sapiens_hsa03440	2.97212660
7	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.84995947
8	Spliceosome_Homo sapiens_hsa03040	2.47418716
9	Basal transcription factors_Homo sapiens_hsa03022	2.41846515
10	One carbon pool by folate_Homo sapiens_hsa00670	2.37965819
11	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.30470923
12	RNA degradation_Homo sapiens_hsa03018	2.17709627
13	RNA polymerase_Homo sapiens_hsa03020	2.12948829
14	Cell cycle_Homo sapiens_hsa04110	2.11723409
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.04288286
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00863991
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.97032952
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.91068111
19	Protein export_Homo sapiens_hsa03060	1.88775836
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.86144642
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.81055888
22	Parkinsons disease_Homo sapiens_hsa05012	1.78127227
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76095936
24	Oocyte meiosis_Homo sapiens_hsa04114	1.71419017
25	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.70697778
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.60337205
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.41932663
28	Proteasome_Homo sapiens_hsa03050	1.40952899
29	Olfactory transduction_Homo sapiens_hsa04740	1.40943269
30	Legionellosis_Homo sapiens_hsa05134	1.35889793
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.30883337
32	Huntingtons disease_Homo sapiens_hsa05016	1.25842631
33	Propanoate metabolism_Homo sapiens_hsa00640	1.21653710
34	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.21630450
35	Ribosome_Homo sapiens_hsa03010	1.17313811
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15588500
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15319072
38	Base excision repair_Homo sapiens_hsa03410	1.13127369
39	Measles_Homo sapiens_hsa05162	1.02730356
40	Purine metabolism_Homo sapiens_hsa00230	1.01972938
41	Carbon metabolism_Homo sapiens_hsa01200	0.98106857
42	Sulfur metabolism_Homo sapiens_hsa00920	0.97628992
43	Acute myeloid leukemia_Homo sapiens_hsa05221	0.96264246
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.95916373
45	ErbB signaling pathway_Homo sapiens_hsa04012	0.94600317
46	Shigellosis_Homo sapiens_hsa05131	0.92426344
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.88300721
48	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.86131983
49	Type II diabetes mellitus_Homo sapiens_hsa04930	0.84139069
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82227256
51	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.79882516
52	mTOR signaling pathway_Homo sapiens_hsa04150	0.75432377
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71815343
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.63541551
55	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.61575880
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61301218
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57957903
58	Alzheimers disease_Homo sapiens_hsa05010	0.57620443
59	Viral carcinogenesis_Homo sapiens_hsa05203	0.57394086
60	VEGF signaling pathway_Homo sapiens_hsa04370	0.54034086
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52783974
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.52003581
63	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.51462381
64	Influenza A_Homo sapiens_hsa05164	0.50079991
65	p53 signaling pathway_Homo sapiens_hsa04115	0.47924680
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47738488
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46480813
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45869770
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43589098
70	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.43044701
71	Insulin signaling pathway_Homo sapiens_hsa04910	0.40169982
72	Regulation of autophagy_Homo sapiens_hsa04140	0.39402668
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36745908
74	Metabolic pathways_Homo sapiens_hsa01100	0.36297493
75	Hepatitis B_Homo sapiens_hsa05161	0.35470248
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35197262
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34639991
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.33118829
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30792835
80	Prolactin signaling pathway_Homo sapiens_hsa04917	0.29468749
81	Butanoate metabolism_Homo sapiens_hsa00650	0.28851836
82	Herpes simplex infection_Homo sapiens_hsa05168	0.28753868
83	Other glycan degradation_Homo sapiens_hsa00511	0.27701706
84	Renal cell carcinoma_Homo sapiens_hsa05211	0.24489293
85	Chemokine signaling pathway_Homo sapiens_hsa04062	0.24090874
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.21717572
87	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.20018033
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.18757750
89	Choline metabolism in cancer_Homo sapiens_hsa05231	0.18230265
90	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.18029347
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.16920450
92	Prion diseases_Homo sapiens_hsa05020	0.16186543
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.14623585
94	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.11315858
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.11164309
96	Adherens junction_Homo sapiens_hsa04520	0.11065730
97	Taste transduction_Homo sapiens_hsa04742	0.10550314
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.10054937
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.09679951
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.08356014

RPL23AP45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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