ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.20495976
2	cytidine deamination (GO:0009972)	5.85688516
3	cytidine metabolic process (GO:0046087)	5.85688516
4	cytidine catabolic process (GO:0006216)	5.85688516
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.59000262
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.85790202
7	chaperone-mediated protein transport (GO:0072321)	4.70305223
8	positive regulation of defense response to virus by host (GO:0002230)	4.38080687
9	ribosomal small subunit assembly (GO:0000028)	4.34327240
10	leukocyte aggregation (GO:0070486)	4.34114074
11	regulation of activation of Janus kinase activity (GO:0010533)	4.24024596
12	regulation of regulatory T cell differentiation (GO:0045589)	4.11079004
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07637248
14	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.03918116
15	water-soluble vitamin biosynthetic process (GO:0042364)	4.00172146
16	activation of MAPKKK activity (GO:0000185)	3.93780460
17	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.87782967
18	negative regulation of mast cell activation (GO:0033004)	3.84799570
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.70262134
20	ATP synthesis coupled proton transport (GO:0015986)	3.70262134
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.60382517
22	positive T cell selection (GO:0043368)	3.59991789
23	electron transport chain (GO:0022900)	3.55752788
24	respiratory electron transport chain (GO:0022904)	3.55181158
25	viral transcription (GO:0019083)	3.52438626
26	maturation of SSU-rRNA (GO:0030490)	3.52008108
27	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.46344152
28	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.42605771
29	positive thymic T cell selection (GO:0045059)	3.39471171
30	translational termination (GO:0006415)	3.36903284
31	pseudouridine synthesis (GO:0001522)	3.33238123
32	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.32800364
33	protein complex biogenesis (GO:0070271)	3.32256462
34	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.24640572
35	translational elongation (GO:0006414)	3.22329630
36	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.21319803
37	termination of RNA polymerase III transcription (GO:0006386)	3.20250691
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.20250691
39	protein neddylation (GO:0045116)	3.19774745
40	regulation of chronic inflammatory response (GO:0002676)	3.17507270
41	iron-sulfur cluster assembly (GO:0016226)	3.17284508
42	metallo-sulfur cluster assembly (GO:0031163)	3.17284508
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16987624
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16987624
45	NADH dehydrogenase complex assembly (GO:0010257)	3.16987624
46	cotranslational protein targeting to membrane (GO:0006613)	3.14261191
47	protein targeting to ER (GO:0045047)	3.13440661
48	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.08658938
49	proteasome assembly (GO:0043248)	3.04980838
50	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.03675948
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.02085667
52	regulation of immunoglobulin secretion (GO:0051023)	3.00773133
53	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.00592169
54	regulation of B cell receptor signaling pathway (GO:0050855)	2.99651642
55	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99438004
56	piRNA metabolic process (GO:0034587)	2.98984464
57	positive regulation of monocyte chemotaxis (GO:0090026)	2.98029139
58	protein localization to endoplasmic reticulum (GO:0070972)	2.97678375
59	regulation of T cell receptor signaling pathway (GO:0050856)	2.96980692
60	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.94120999
61	cellular response to interleukin-15 (GO:0071350)	2.90843948
62	response to pheromone (GO:0019236)	2.90823715
63	cytolysis (GO:0019835)	2.90789317
64	regulation of isotype switching to IgG isotypes (GO:0048302)	2.90405783
65	positive regulation of T cell apoptotic process (GO:0070234)	2.90036430
66	negative T cell selection (GO:0043383)	2.89487318
67	positive regulation of cell killing (GO:0031343)	2.88409946
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.87357537
69	protein deneddylation (GO:0000338)	2.86625346
70	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.84075407
71	positive regulation of calcium-mediated signaling (GO:0050850)	2.82658209
72	regulation of T cell chemotaxis (GO:0010819)	2.80181010
73	positive regulation of T cell chemotaxis (GO:0010820)	2.80181010
74	negative regulation of T cell apoptotic process (GO:0070233)	2.78888294
75	platelet dense granule organization (GO:0060155)	2.78225892
76	regulation of T cell mediated cytotoxicity (GO:0001914)	2.74979877
77	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.72594634
78	regulation of natural killer cell mediated immunity (GO:0002715)	2.72594634
79	positive regulation of T cell migration (GO:2000406)	2.70612601
80	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.70604273
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70404689
82	activated T cell proliferation (GO:0050798)	2.68142532
83	translation (GO:0006412)	2.64702780
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64604196
85	negative regulation by host of viral transcription (GO:0043922)	2.64577098
86	ribosomal small subunit biogenesis (GO:0042274)	2.62742104
87	regulation of defense response to virus by host (GO:0050691)	2.62344509
88	pyrimidine nucleoside catabolic process (GO:0046135)	2.62033978
89	Peyers patch development (GO:0048541)	2.61974999
90	mucosal-associated lymphoid tissue development (GO:0048537)	2.61974999
91	positive regulation of lymphocyte migration (GO:2000403)	2.61376439
92	regulation of cell killing (GO:0031341)	2.58607522
93	regulation of lymphocyte migration (GO:2000401)	2.58241162
94	T cell receptor signaling pathway (GO:0050852)	2.57298918
95	positive regulation of T-helper 1 type immune response (GO:0002827)	2.56761493
96	regulation of cellular amino acid metabolic process (GO:0006521)	2.56687713
97	positive regulation of interleukin-17 production (GO:0032740)	2.54864905
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.53887771
99	adaptation of signaling pathway (GO:0023058)	2.53887423
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.52709025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.27835957
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.00092354
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.66018186
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.44014747
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.38721909
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.24355329
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82713745
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.64809121
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63849469
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.52490542
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45348483
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44953259
13	VDR_22108803_ChIP-Seq_LS180_Human	2.41104078
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37791840
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31137606
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.26453413
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.25710754
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.20972451
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.19112464
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11652205
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06459700
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92074166
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88877566
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.76120335
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69596209
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67896001
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.65028754
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56517262
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56221607
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.52719699
31	MYB_26560356_Chip-Seq_TH2_Human	1.51643556
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51318356
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50662644
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48391650
35	EWS_26573619_Chip-Seq_HEK293_Human	1.47604264
36	AR_20517297_ChIP-Seq_VCAP_Human	1.46311404
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.46082631
38	RUNX_20019798_ChIP-Seq_JUKART_Human	1.41128204
39	GATA3_26560356_Chip-Seq_TH2_Human	1.38742129
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36825569
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36287270
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36210750
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.34385379
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.32451555
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32170923
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32170923
47	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.28520213
48	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.27677261
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.26009141
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24844687
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24485741
52	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21135545
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20615356
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19146510
55	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.18924100
56	NCOR_22424771_ChIP-Seq_293T_Human	1.17881950
57	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17217842
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17052660
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15788818
60	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14787778
61	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13667222
62	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13360606
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13069728
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12608712
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12125601
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12070410
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11736670
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.10058986
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.07284927
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.07156553
71	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.04812734
72	ERA_21632823_ChIP-Seq_H3396_Human	1.04175887
73	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.03463154
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03461182
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03060275
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01868637
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00505388
78	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00415980
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99769814
80	MYC_19829295_ChIP-Seq_ESCs_Human	0.98866532
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98270140
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98270140
83	FUS_26573619_Chip-Seq_HEK293_Human	0.97721108
84	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97654645
85	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96306700
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95811340
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94873937
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94742977
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94393308
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94039101
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93534750
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93156264
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.91845045
94	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91184017
95	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90811311
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.89793157
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89068493
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.88433897
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87938094
100	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.87649378

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.30623328
2	MP0001835_abnormal_antigen_presentation	2.83921264
3	MP0008872_abnormal_physiological_respon	2.59626882
4	MP0005623_abnormal_meninges_morphology	2.53963901
5	MP0009785_altered_susceptibility_to	2.36439739
6	MP0005645_abnormal_hypothalamus_physiol	2.27162622
7	MP0006072_abnormal_retinal_apoptosis	2.23428707
8	MP0003786_premature_aging	2.18320418
9	MP0002837_dystrophic_cardiac_calcinosis	2.13470352
10	MP0002102_abnormal_ear_morphology	2.07517309
11	MP0002163_abnormal_gland_morphology	2.07305496
12	MP0003763_abnormal_thymus_physiology	2.06573807
13	MP0004885_abnormal_endolymph	2.05550084
14	MP0002277_abnormal_respiratory_mucosa	2.02150911
15	MP0001800_abnormal_humoral_immune	1.89129272
16	MP0005387_immune_system_phenotype	1.86431323
17	MP0001790_abnormal_immune_system	1.86431323
18	MP0005379_endocrine/exocrine_gland_phen	1.86233389
19	MP0002148_abnormal_hypersensitivity_rea	1.83311669
20	MP0003866_abnormal_defecation	1.76853136
21	MP0002638_abnormal_pupillary_reflex	1.74909895
22	MP0009333_abnormal_splenocyte_physiolog	1.74352610
23	MP0005551_abnormal_eye_electrophysiolog	1.73056761
24	MP0000685_abnormal_immune_system	1.72735414
25	MP0009384_cardiac_valve_regurgitation	1.71962671
26	MP0005000_abnormal_immune_tolerance	1.71950039
27	MP0004147_increased_porphyrin_level	1.70328810
28	MP0008877_abnormal_DNA_methylation	1.67230203
29	MP0001984_abnormal_olfaction	1.64067320
30	MP0002723_abnormal_immune_serum	1.61061045
31	MP0001873_stomach_inflammation	1.58733128
32	MP0002420_abnormal_adaptive_immunity	1.58669344
33	MP0003195_calcinosis	1.58624158
34	MP0002736_abnormal_nociception_after	1.57365430
35	MP0003878_abnormal_ear_physiology	1.54553933
36	MP0005377_hearing/vestibular/ear_phenot	1.54553933
37	MP0001968_abnormal_touch/_nociception	1.54019640
38	MP0001819_abnormal_immune_cell	1.52235815
39	MP0009379_abnormal_foot_pigmentation	1.47146912
40	MP0008875_abnormal_xenobiotic_pharmacok	1.46478840
41	MP0005025_abnormal_response_to	1.36909855
42	MP0005389_reproductive_system_phenotype	1.36338888
43	MP0006082_CNS_inflammation	1.34426331
44	MP0001905_abnormal_dopamine_level	1.33644783
45	MP0005410_abnormal_fertilization	1.32686936
46	MP0005646_abnormal_pituitary_gland	1.31869151
47	MP0003011_delayed_dark_adaptation	1.30744660
48	MP0002160_abnormal_reproductive_system	1.26340737
49	MP0002166_altered_tumor_susceptibility	1.26246585
50	MP0002452_abnormal_antigen_presenting	1.25708044
51	MP0004142_abnormal_muscle_tone	1.25038670
52	MP0006036_abnormal_mitochondrial_physio	1.24400919
53	MP0010155_abnormal_intestine_physiology	1.22962685
54	MP0005253_abnormal_eye_physiology	1.22221788
55	MP0001529_abnormal_vocalization	1.21590413
56	MP0002876_abnormal_thyroid_physiology	1.21132882
57	MP0001986_abnormal_taste_sensitivity	1.19483625
58	MP0000013_abnormal_adipose_tissue	1.17041261
59	MP0003137_abnormal_impulse_conducting	1.10770015
60	MP0000716_abnormal_immune_system	1.08322800
61	MP0000750_abnormal_muscle_regeneration	1.07469266
62	MP0001919_abnormal_reproductive_system	1.07276426
63	MP0006292_abnormal_olfactory_placode	1.06551863
64	MP0000703_abnormal_thymus_morphology	1.06222689
65	MP0009764_decreased_sensitivity_to	1.05429103
66	MP0001485_abnormal_pinna_reflex	1.05171420
67	MP0006035_abnormal_mitochondrial_morpho	1.03344416
68	MP0008995_early_reproductive_senescence	1.01532928
69	MP0000689_abnormal_spleen_morphology	1.01371391
70	MP0003646_muscle_fatigue	0.99445396
71	MP0002722_abnormal_immune_system	0.98406647
72	MP0002398_abnormal_bone_marrow	0.98188687
73	MP0002933_joint_inflammation	0.94089576
74	MP0001845_abnormal_inflammatory_respons	0.93216817
75	MP0002938_white_spotting	0.92922224
76	MP0002006_tumorigenesis	0.92410330
77	MP0005636_abnormal_mineral_homeostasis	0.92155412
78	MP0008469_abnormal_protein_level	0.90366990
79	MP0002272_abnormal_nervous_system	0.89963636
80	MP0008058_abnormal_DNA_repair	0.87134455
81	MP0001853_heart_inflammation	0.87125186
82	MP0009745_abnormal_behavioral_response	0.86935713
83	MP0004145_abnormal_muscle_electrophysio	0.86774779
84	MP0006276_abnormal_autonomic_nervous	0.86569575
85	MP0005084_abnormal_gallbladder_morpholo	0.85143338
86	MP0002405_respiratory_system_inflammati	0.78328705
87	MP0001502_abnormal_circadian_rhythm	0.77176239
88	MP0002693_abnormal_pancreas_physiology	0.76243764
89	MP0002429_abnormal_blood_cell	0.76186580
90	MP0000631_abnormal_neuroendocrine_gland	0.75504963
91	MP0002019_abnormal_tumor_incidence	0.73600320
92	MP0002419_abnormal_innate_immunity	0.73378468
93	MP0004947_skin_inflammation	0.71861311
94	MP0003045_fibrosis	0.70265356
95	MP0004215_abnormal_myocardial_fiber	0.70165635
96	MP0001501_abnormal_sleep_pattern	0.68188583
97	MP0000372_irregular_coat_pigmentation	0.68115186
98	MP0009763_increased_sensitivity_to	0.66652894
99	MP0010386_abnormal_urinary_bladder	0.66579720
100	MP0002067_abnormal_sensory_capabilities	0.65991101

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	5.78717104
2	Type II lissencephaly (HP:0007260)	5.50801458
3	Decreased electroretinogram (ERG) amplitude (HP:0000654)	5.01196418
4	Hypoplasia of the pons (HP:0012110)	4.85556930
5	Retinal atrophy (HP:0001105)	4.80426746
6	Abnormality of the pons (HP:0007361)	4.79968954
7	IgG deficiency (HP:0004315)	4.22338817
8	Elevated erythrocyte sedimentation rate (HP:0003565)	4.15851125
9	Increased IgM level (HP:0003496)	3.87904984
10	Congenital stationary night blindness (HP:0007642)	3.77732110
11	Acute necrotizing encephalopathy (HP:0006965)	3.73895004
12	Abolished electroretinogram (ERG) (HP:0000550)	3.69558240
13	Stomatitis (HP:0010280)	3.68011747
14	Retinal dysplasia (HP:0007973)	3.62126355
15	Mitochondrial inheritance (HP:0001427)	3.30667705
16	Abnormality of T cell number (HP:0011839)	3.24099616
17	Aplastic anemia (HP:0001915)	3.16463018
18	Abnormal mitochondria in muscle tissue (HP:0008316)	3.15546185
19	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.14275033
20	Progressive macrocephaly (HP:0004481)	3.09930502
21	Hypoproteinemia (HP:0003075)	3.05238098
22	T lymphocytopenia (HP:0005403)	3.02572378
23	Acute encephalopathy (HP:0006846)	2.99043787
24	3-Methylglutaconic aciduria (HP:0003535)	2.88867265
25	Fatigue (HP:0012378)	2.88436512
26	Increased CSF lactate (HP:0002490)	2.86951152
27	Pancreatic cysts (HP:0001737)	2.85438039
28	Severe muscular hypotonia (HP:0006829)	2.74133889
29	Abnormality of the renal cortex (HP:0011035)	2.72045171
30	Colon cancer (HP:0003003)	2.67821202
31	Abnormality of midbrain morphology (HP:0002418)	2.67217884
32	Molar tooth sign on MRI (HP:0002419)	2.67217884
33	Papilledema (HP:0001085)	2.60937165
34	Nephronophthisis (HP:0000090)	2.53608271
35	Asplenia (HP:0001746)	2.53160770
36	Severe combined immunodeficiency (HP:0004430)	2.52389062
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50747173
38	Abnormality of T cells (HP:0002843)	2.47648109
39	Pancreatic fibrosis (HP:0100732)	2.47279890
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44720431
41	Abnormality of eosinophils (HP:0001879)	2.41814058
42	Methylmalonic acidemia (HP:0002912)	2.38996548
43	Autoimmune hemolytic anemia (HP:0001890)	2.37630122
44	Renal cortical cysts (HP:0000803)	2.32551420
45	Cerebral edema (HP:0002181)	2.32525566
46	Hypoalbuminemia (HP:0003073)	2.30563481
47	Abnormal albumin level (HP:0012116)	2.30563481
48	True hermaphroditism (HP:0010459)	2.30397994
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.27565256
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25453802
51	Absent/shortened dynein arms (HP:0200106)	2.25453802
52	Optic disc pallor (HP:0000543)	2.23904823
53	Eosinophilia (HP:0001880)	2.21258288
54	Abnormality of B cell number (HP:0010975)	2.21178489
55	Abnormality of the renal medulla (HP:0100957)	2.16945187
56	Increased hepatocellular lipid droplets (HP:0006565)	2.14254451
57	Lipid accumulation in hepatocytes (HP:0006561)	2.14216289
58	Hepatocellular necrosis (HP:0001404)	2.11739221
59	Abnormal drinking behavior (HP:0030082)	2.11735009
60	Polydipsia (HP:0001959)	2.11735009
61	Hepatic necrosis (HP:0002605)	2.11462116
62	Leukocytosis (HP:0001974)	2.10051291
63	Constricted visual fields (HP:0001133)	2.09865409
64	Pancytopenia (HP:0001876)	2.09266427
65	Exertional dyspnea (HP:0002875)	2.07401533
66	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.04722267
67	Methylmalonic aciduria (HP:0012120)	2.03700367
68	Lissencephaly (HP:0001339)	2.03073364
69	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02868493
70	Stomach cancer (HP:0012126)	2.02470589
71	Buphthalmos (HP:0000557)	2.02157677
72	Chronic hepatic failure (HP:0100626)	2.01707787
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.01334355
74	Abnormality of alanine metabolism (HP:0010916)	2.00883079
75	Hyperalaninemia (HP:0003348)	2.00883079
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00883079
77	Thyroiditis (HP:0100646)	1.99889187
78	Hyperglycinemia (HP:0002154)	1.97866155
79	Attenuation of retinal blood vessels (HP:0007843)	1.92458615
80	Difficulty climbing stairs (HP:0003551)	1.92345538
81	Lactic acidosis (HP:0003128)	1.91948404
82	Intellectual disability, profound (HP:0002187)	1.91645343
83	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.91320012
84	Encephalitis (HP:0002383)	1.89913577
85	Increased serum lactate (HP:0002151)	1.89091780
86	Concave nail (HP:0001598)	1.87362298
87	Fibular aplasia (HP:0002990)	1.86958628
88	Entropion (HP:0000621)	1.85844994
89	Mesangial abnormality (HP:0001966)	1.83860449
90	Pachygyria (HP:0001302)	1.82709638
91	Congenital, generalized hypertrichosis (HP:0004540)	1.82335909
92	Medial flaring of the eyebrow (HP:0010747)	1.79038291
93	Combined immunodeficiency (HP:0005387)	1.78658324
94	Polyuria (HP:0000103)	1.78492737
95	Chronic diarrhea (HP:0002028)	1.77531267
96	Respiratory failure (HP:0002878)	1.76275860
97	Acute hepatic failure (HP:0006554)	1.75866877
98	Abnormality of T cell physiology (HP:0011840)	1.75484487
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.74885308
100	Abnormality of DNA repair (HP:0003254)	1.72179490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.45464569
2	ZAK	3.54397850
3	TLK1	3.25213032
4	KDR	3.25153522
5	STK10	3.20167103
6	MARK3	2.78107044
7	ADRBK2	2.63111262
8	BCKDK	2.32279671
9	PASK	2.17606283
10	WNK4	2.13634484
11	MAP4K1	2.07655196
12	MST4	2.06345997
13	VRK2	2.05366354
14	PINK1	1.97917210
15	GRK7	1.95688237
16	GRK1	1.94512651
17	VRK1	1.86256704
18	TESK2	1.73073462
19	ITK	1.70402493
20	TEC	1.65377013
21	FRK	1.61783209
22	CAMKK2	1.55005322
23	PIM1	1.54367930
24	MAP4K2	1.48728900
25	PTK2B	1.44262597
26	MAP2K6	1.41104188
27	MUSK	1.40055156
28	NME1	1.36011565
29	NUAK1	1.34983709
30	MAP3K11	1.24731430
31	TAOK3	1.23291758
32	DAPK2	1.19511845
33	GRK6	1.18384362
34	BTK	1.11990292
35	SRPK1	1.11739818
36	BUB1	1.10080955
37	CSNK1G3	1.07796197
38	IKBKB	1.07242924
39	CAMKK1	1.03847524
40	INSRR	1.00557465
41	LCK	0.95216009
42	STK11	0.92663212
43	CSNK1A1L	0.88489336
44	FES	0.87301296
45	CLK1	0.82284766
46	CSNK1G2	0.80725929
47	PRKCQ	0.80709973
48	STK39	0.78502430
49	WNK3	0.77965588
50	LMTK2	0.76898980
51	NEK1	0.73654043
52	PRKCH	0.73121399
53	SYK	0.72932948
54	IRAK4	0.71101002
55	CSNK1G1	0.69069377
56	TIE1	0.68346002
57	OXSR1	0.67834723
58	RPS6KA5	0.67500287
59	GRK5	0.66692693
60	CSK	0.63203956
61	ADRBK1	0.62609749
62	EIF2AK1	0.60100041
63	EIF2AK3	0.58093915
64	OBSCN	0.56637568
65	PIK3CG	0.55717425
66	LYN	0.54449285
67	IKBKE	0.53996670
68	KIT	0.52648450
69	MAP3K12	0.51242727
70	CDK19	0.50254036
71	PHKG1	0.49533968
72	PHKG2	0.49533968
73	TNK2	0.47672192
74	PLK4	0.47091298
75	PRKCA	0.47080364
76	IGF1R	0.46211980
77	TAF1	0.45693485
78	TSSK6	0.44609414
79	PIK3CA	0.44058576
80	CASK	0.43490569
81	MAPK13	0.43114900
82	PRKACA	0.43067021
83	TRIM28	0.43045788
84	PRKCE	0.41699952
85	DYRK2	0.41631343
86	JAK3	0.39888061
87	TAOK2	0.39138818
88	HCK	0.37812715
89	ZAP70	0.35068942
90	CSNK2A1	0.34578444
91	MYLK	0.33300908
92	CSNK2A2	0.32325593
93	NME2	0.32112670
94	NLK	0.31983779
95	CSF1R	0.31071480
96	PLK3	0.30145378
97	TNIK	0.30041005
98	AURKA	0.29399625
99	CDK8	0.29297029
100	TESK1	0.28277660

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.85545327
2	Ribosome_Homo sapiens_hsa03010	3.55544974
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.41546971
4	Proteasome_Homo sapiens_hsa03050	3.20087851
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.14456344
6	Allograft rejection_Homo sapiens_hsa05330	2.98109646
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.92142387
8	Parkinsons disease_Homo sapiens_hsa05012	2.82906711
9	RNA polymerase_Homo sapiens_hsa03020	2.57706847
10	Asthma_Homo sapiens_hsa05310	2.46169242
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.35536382
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.26923518
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.12666389
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.11706305
15	Protein export_Homo sapiens_hsa03060	2.07360088
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95060001
17	Alzheimers disease_Homo sapiens_hsa05010	1.81922844
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.76556221
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.75012392
20	Huntingtons disease_Homo sapiens_hsa05016	1.73685759
21	Phototransduction_Homo sapiens_hsa04744	1.61917139
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.57159278
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.52279624
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51324844
25	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.46711488
26	One carbon pool by folate_Homo sapiens_hsa00670	1.45284466
27	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.39000014
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.32425428
29	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.32380087
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.30216589
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.22378941
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12010002
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11136247
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11073157
35	RNA degradation_Homo sapiens_hsa03018	1.10415526
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.08634673
37	Caffeine metabolism_Homo sapiens_hsa00232	1.08450363
38	Basal transcription factors_Homo sapiens_hsa03022	1.07763162
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07380693
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06048070
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.05902895
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05334338
43	Homologous recombination_Homo sapiens_hsa03440	0.97219461
44	Peroxisome_Homo sapiens_hsa04146	0.94993771
45	Regulation of autophagy_Homo sapiens_hsa04140	0.88314912
46	Purine metabolism_Homo sapiens_hsa00230	0.86589907
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83313789
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79446847
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76054479
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75787459
51	Viral myocarditis_Homo sapiens_hsa05416	0.75500668
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73548380
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66737876
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65192791
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64903889
56	Propanoate metabolism_Homo sapiens_hsa00640	0.64721278
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.62579894
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61554347
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60656306
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60047709
61	Sulfur relay system_Homo sapiens_hsa04122	0.59539407
62	Leishmaniasis_Homo sapiens_hsa05140	0.59324946
63	Base excision repair_Homo sapiens_hsa03410	0.59059069
64	DNA replication_Homo sapiens_hsa03030	0.57334883
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56814296
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55787774
67	Measles_Homo sapiens_hsa05162	0.53132191
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52950828
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52470790
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52197629
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51855301
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49089904
73	Metabolic pathways_Homo sapiens_hsa01100	0.48997962
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48899273
75	Retinol metabolism_Homo sapiens_hsa00830	0.48524188
76	Butanoate metabolism_Homo sapiens_hsa00650	0.47388190
77	Olfactory transduction_Homo sapiens_hsa04740	0.46966735
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45652024
79	Mismatch repair_Homo sapiens_hsa03430	0.43387857
80	TNF signaling pathway_Homo sapiens_hsa04668	0.42730462
81	Spliceosome_Homo sapiens_hsa03040	0.41540515
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.40072410
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38945000
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38277179
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38233872
86	Nicotine addiction_Homo sapiens_hsa05033	0.35871266
87	Mineral absorption_Homo sapiens_hsa04978	0.34222255
88	Fanconi anemia pathway_Homo sapiens_hsa03460	0.31524339
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.31381245
90	Taste transduction_Homo sapiens_hsa04742	0.31266127
91	Herpes simplex infection_Homo sapiens_hsa05168	0.30284847
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29081681
93	RNA transport_Homo sapiens_hsa03013	0.28411689
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28317502
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26157582
96	Malaria_Homo sapiens_hsa05144	0.25586626
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.23925727
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.23365342
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.20392014
100	Sulfur metabolism_Homo sapiens_hsa00920	0.19436455

RPL23AP46

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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