ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	granulocyte differentiation (GO:0030851)	7.48733032
2	positive regulation of osteoblast proliferation (GO:0033690)	7.32093426
3	cellular response to thyroid hormone stimulus (GO:0097067)	6.94851002
4	erythrocyte development (GO:0048821)	6.57720158
5	nuclear pore complex assembly (GO:0051292)	6.16822962
6	response to thyroid hormone (GO:0097066)	5.71771979
7	DNA unwinding involved in DNA replication (GO:0006268)	5.61429413
8	nuclear pore organization (GO:0006999)	5.45620352
9	negative regulation of bone mineralization (GO:0030502)	5.15423595
10	platelet formation (GO:0030220)	4.92558614
11	nuclear envelope reassembly (GO:0031468)	4.90360594
12	mitotic nuclear envelope reassembly (GO:0007084)	4.90360594
13	diterpenoid biosynthetic process (GO:0016102)	4.88386366
14	oxidative phosphorylation (GO:0006119)	4.84896147
15	centriole replication (GO:0007099)	4.80956882
16	DNA replication checkpoint (GO:0000076)	4.61756813
17	synapsis (GO:0007129)	4.57942584
18	pore complex assembly (GO:0046931)	4.57207350
19	positive regulation of erythrocyte differentiation (GO:0045648)	4.55537322
20	negative regulation of biomineral tissue development (GO:0070168)	4.45931107
21	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.45819027
22	DNA replication initiation (GO:0006270)	4.44771926
23	adenine nucleotide transport (GO:0051503)	4.39918582
24	regulation of histone H3-K4 methylation (GO:0051569)	4.29083604
25	regulation of RNA export from nucleus (GO:0046831)	4.24287975
26	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	4.16987803
27	regulation of DNA methylation (GO:0044030)	4.06812866
28	protein localization to kinetochore (GO:0034501)	3.99942696
29	DNA topological change (GO:0006265)	3.99632234
30	purine ribonucleotide transport (GO:0015868)	3.99442464
31	meiotic chromosome segregation (GO:0045132)	3.92044553
32	DNA synthesis involved in DNA repair (GO:0000731)	3.90639194
33	DNA strand elongation involved in DNA replication (GO:0006271)	3.90568788
34	terpenoid biosynthetic process (GO:0016114)	3.89820762
35	negative regulation of erythrocyte differentiation (GO:0045647)	3.89393606
36	mitotic nuclear envelope disassembly (GO:0007077)	3.87341668
37	centriole assembly (GO:0098534)	3.83991184
38	mitochondrial calcium ion transport (GO:0006851)	3.83784311
39	regulation of erythrocyte differentiation (GO:0045646)	3.80765967
40	DNA strand elongation (GO:0022616)	3.78305205
41	regulation of histone H3-K27 methylation (GO:0061085)	3.75475989
42	DNA methylation involved in gamete generation (GO:0043046)	3.73115605
43	myeloid cell development (GO:0061515)	3.68455224
44	definitive hemopoiesis (GO:0060216)	3.66041171
45	replication fork processing (GO:0031297)	3.65354552
46	protoporphyrinogen IX metabolic process (GO:0046501)	3.62169062
47	mitotic chromosome condensation (GO:0007076)	3.61286704
48	embryonic hemopoiesis (GO:0035162)	3.57590042
49	membrane disassembly (GO:0030397)	3.55800554
50	nuclear envelope disassembly (GO:0051081)	3.55800554
51	mitotic sister chromatid segregation (GO:0000070)	3.54377816
52	sister chromatid segregation (GO:0000819)	3.54091247
53	creatine metabolic process (GO:0006600)	3.51934175
54	protein localization to chromosome, centromeric region (GO:0071459)	3.47685026
55	chromosome organization involved in meiosis (GO:0070192)	3.47636099
56	intra-S DNA damage checkpoint (GO:0031573)	3.47460953
57	aerobic respiration (GO:0009060)	3.47235379
58	regulation of histone H3-K9 methylation (GO:0051570)	3.45458823
59	regulation of histone methylation (GO:0031060)	3.44346878
60	viral mRNA export from host cell nucleus (GO:0046784)	3.42918383
61	monoubiquitinated protein deubiquitination (GO:0035520)	3.42034135
62	negative regulation of gluconeogenesis (GO:0045721)	3.40928789
63	nuclear envelope organization (GO:0006998)	3.40430992
64	chromosome segregation (GO:0007059)	3.36808383
65	positive regulation of cell cycle checkpoint (GO:1901978)	3.36534017
66	purine nucleotide transport (GO:0015865)	3.35527980
67	regulation of nucleobase-containing compound transport (GO:0032239)	3.33985601
68	resolution of meiotic recombination intermediates (GO:0000712)	3.33312216
69	purine nucleobase biosynthetic process (GO:0009113)	3.32743647
70	negative regulation of histone methylation (GO:0031061)	3.32038143
71	regulation of translational fidelity (GO:0006450)	3.28160881
72	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.20246682
73	negative regulation of translational initiation (GO:0045947)	3.18600448
74	mitotic sister chromatid cohesion (GO:0007064)	3.18598381
75	vitamin A metabolic process (GO:0006776)	3.13320261
76	tetrahydrofolate metabolic process (GO:0046653)	3.11396415
77	valine metabolic process (GO:0006573)	3.10672293
78	telomere maintenance via semi-conservative replication (GO:0032201)	3.10233080
79	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.10216691
80	gas transport (GO:0015669)	3.09237013
81	ribosome biogenesis (GO:0042254)	3.07647352
82	positive regulation of insulin receptor signaling pathway (GO:0046628)	3.07435399
83	positive regulation of gene expression, epigenetic (GO:0045815)	3.04395323
84	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.00525281
85	regulation of centriole replication (GO:0046599)	2.99041730
86	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.98886003
87	mitotic recombination (GO:0006312)	2.98523304
88	positive regulation of histone methylation (GO:0031062)	2.97958816
89	histone H3-K9 demethylation (GO:0033169)	2.95842379
90	CENP-A containing nucleosome assembly (GO:0034080)	2.95009292
91	telomere maintenance via recombination (GO:0000722)	2.92636962
92	nucleobase biosynthetic process (GO:0046112)	2.90297913
93	response to vitamin A (GO:0033189)	2.87357875
94	histone phosphorylation (GO:0016572)	2.86091232
95	homocysteine metabolic process (GO:0050667)	2.85590854
96	attachment of spindle microtubules to kinetochore (GO:0008608)	2.85059271
97	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.83771941
98	centrosome duplication (GO:0051298)	2.83549704
99	regulation of spindle organization (GO:0090224)	2.83359394
100	oxygen transport (GO:0015671)	2.82761794

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.44731419
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.53748131
3	GATA1_22025678_ChIP-Seq_K562_Human	4.10957287
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.24848287
5	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.24492041
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.01890810
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94541414
8	GATA1_19941826_ChIP-Seq_K562_Human	2.94001795
9	NCOR1_26117541_ChIP-Seq_K562_Human	2.92428598
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.83788661
11	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.61140608
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.37504321
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.31190377
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.31083029
15	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.22646220
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.15730119
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10247439
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03768012
19	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.02997794
20	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.02073080
21	GATA2_19941826_ChIP-Seq_K562_Human	1.98169919
22	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.97523266
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.96625676
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.93792281
25	SPI1_23127762_ChIP-Seq_K562_Human	1.83185042
26	XRN2_22483619_ChIP-Seq_HELA_Human	1.81438122
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80328650
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.79913613
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72188036
30	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.70866669
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.70390977
32	KDM5A_27292631_Chip-Seq_BREAST_Human	1.69270905
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69244319
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.65710546
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.61458647
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.56748596
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.49892659
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48716640
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45528136
40	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.42615326
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.39685918
42	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.36612367
43	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.36131400
44	SCL_19346495_ChIP-Seq_HPC-7_Human	1.35421575
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.35056011
46	MYC_22102868_ChIP-Seq_BL_Human	1.34677976
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32159254
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30841737
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29395956
50	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.28690483
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28566628
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27514506
53	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.21893419
54	TFEB_21752829_ChIP-Seq_HELA_Human	1.21142582
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.20348290
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.20325872
57	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.19275046
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.18028545
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17175821
60	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.16446256
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15968766
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15924827
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.14233858
64	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.14187133
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.13449638
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11918051
67	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.11538728
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11200596
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10615188
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08069096
71	SPI1_23547873_ChIP-Seq_NB4_Human	1.06821252
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.04417714
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04260722
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03746961
75	AR_21909140_ChIP-Seq_LNCAP_Human	1.03484457
76	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.02995476
77	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.02372434
78	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.02291166
79	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.02291166
80	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.02291166
81	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.01827430
82	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.01431499
83	ZNF263_19887448_ChIP-Seq_K562_Human	1.00498275
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00291832
85	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.99813852
86	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.99300504
87	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.98774797
88	MAF_26560356_Chip-Seq_TH2_Human	0.95438369
89	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.94337776
90	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92843261
91	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.92438302
92	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.91928238
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.90566784
94	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.89021483
95	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.88704232
96	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.88185154
97	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.87016254
98	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.86024554
99	MYB_26560356_Chip-Seq_TH1_Human	0.84205646
100	VDR_21846776_ChIP-Seq_THP-1_Human	0.80191527

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002132_abnormal_respiratory_system	7.06246901
2	MP0001661_extended_life_span	4.09957344
3	MP0004147_increased_porphyrin_level	3.87572485
4	MP0003111_abnormal_nucleus_morphology	3.81671271
5	MP0001545_abnormal_hematopoietic_system	3.78690643
6	MP0005397_hematopoietic_system_phenotyp	3.78690643
7	MP0000678_abnormal_parathyroid_gland	3.51668356
8	MP0010094_abnormal_chromosome_stability	3.39159014
9	MP0003693_abnormal_embryo_hatching	3.37896758
10	MP0008057_abnormal_DNA_replication	3.05968631
11	MP0008995_early_reproductive_senescence	2.92790372
12	MP0008058_abnormal_DNA_repair	2.79987361
13	MP0004957_abnormal_blastocyst_morpholog	2.74489629
14	MP0003718_maternal_effect	2.51482856
15	MP0003656_abnormal_erythrocyte_physiolo	2.47002199
16	MP0008932_abnormal_embryonic_tissue	2.39247373
17	MP0005451_abnormal_body_composition	2.37926101
18	MP0003077_abnormal_cell_cycle	2.22310072
19	MP0006036_abnormal_mitochondrial_physio	2.21071716
20	MP0009697_abnormal_copulation	2.13486897
21	MP0005360_urolithiasis	1.92498922
22	MP0001697_abnormal_embryo_size	1.86433977
23	MP0003786_premature_aging	1.62700246
24	MP0000313_abnormal_cell_death	1.61347775
25	MP0005083_abnormal_biliary_tract	1.57468600
26	MP0005636_abnormal_mineral_homeostasis	1.51046940
27	MP0010307_abnormal_tumor_latency	1.47711821
28	MP0001730_embryonic_growth_arrest	1.47400606
29	MP0000350_abnormal_cell_proliferation	1.45407879
30	MP0002210_abnormal_sex_determination	1.42492199
31	MP0008877_abnormal_DNA_methylation	1.41549165
32	MP0003950_abnormal_plasma_membrane	1.41081433
33	MP0008007_abnormal_cellular_replicative	1.40609565
34	MP0001929_abnormal_gametogenesis	1.39826287
35	MP0006035_abnormal_mitochondrial_morpho	1.32349947
36	MP0002080_prenatal_lethality	1.28676273
37	MP0005171_absent_coat_pigmentation	1.26370962
38	MP0008872_abnormal_physiological_respon	1.24550119
39	MP0002396_abnormal_hematopoietic_system	1.21875975
40	MP0002249_abnormal_larynx_morphology	1.17769676
41	MP0000703_abnormal_thymus_morphology	1.14434370
42	MP0002139_abnormal_hepatobiliary_system	1.14152432
43	MP0005380_embryogenesis_phenotype	1.14013664
44	MP0001672_abnormal_embryogenesis/_devel	1.14013664
45	MP0001853_heart_inflammation	1.06952810
46	MP0000372_irregular_coat_pigmentation	1.05722605
47	MP0002086_abnormal_extraembryonic_tissu	1.02936326
48	MP0000747_muscle_weakness	1.02901914
49	MP0001145_abnormal_male_reproductive	1.02384203
50	MP0003699_abnormal_female_reproductive	1.01643560
51	MP0003186_abnormal_redox_activity	1.01336751
52	MP0003984_embryonic_growth_retardation	0.99950507
53	MP0003698_abnormal_male_reproductive	0.97966459
54	MP0002722_abnormal_immune_system	0.97555648
55	MP0008775_abnormal_heart_ventricle	0.96914120
56	MP0006292_abnormal_olfactory_placode	0.95148459
57	MP0009333_abnormal_splenocyte_physiolog	0.95005351
58	MP0009278_abnormal_bone_marrow	0.94945114
59	MP0003890_abnormal_embryonic-extraembry	0.94748826
60	MP0002088_abnormal_embryonic_growth/wei	0.94301038
61	MP0008770_decreased_survivor_rate	0.93910125
62	MP0000653_abnormal_sex_gland	0.93501576
63	MP0009672_abnormal_birth_weight	0.91656953
64	MP0005076_abnormal_cell_differentiation	0.90681426
65	MP0001764_abnormal_homeostasis	0.89589416
66	MP0004145_abnormal_muscle_electrophysio	0.89154248
67	MP0004808_abnormal_hematopoietic_stem	0.89098039
68	MP0002398_abnormal_bone_marrow	0.87357342
69	MP0003959_abnormal_lean_body	0.82613416
70	MP0002084_abnormal_developmental_patter	0.82408525
71	MP0003385_abnormal_body_wall	0.82256027
72	MP0009931_abnormal_skin_appearance	0.80704362
73	MP0003646_muscle_fatigue	0.80628135
74	MP0005464_abnormal_platelet_physiology	0.78668443
75	MP0002161_abnormal_fertility/fecundity	0.78047313
76	MP0002019_abnormal_tumor_incidence	0.76809907
77	MP0002234_abnormal_pharynx_morphology	0.76166878
78	MP0003453_abnormal_keratinocyte_physiol	0.74519019
79	MP0000681_abnormal_thyroid_gland	0.73231333
80	MP0005410_abnormal_fertilization	0.72927343
81	MP0002085_abnormal_embryonic_tissue	0.71241997
82	MP0010630_abnormal_cardiac_muscle	0.70130451
83	MP0004197_abnormal_fetal_growth/weight/	0.70043208
84	MP0004782_abnormal_surfactant_physiolog	0.69819384
85	MP0005395_other_phenotype	0.67776322
86	MP0000358_abnormal_cell_content/	0.66972337
87	MP0000598_abnormal_liver_morphology	0.64578290
88	MP0000689_abnormal_spleen_morphology	0.64313361
89	MP0005647_abnormal_sex_gland	0.63941315
90	MP0009703_decreased_birth_body	0.63774620
91	MP0002269_muscular_atrophy	0.63769400
92	MP0004233_abnormal_muscle_weight	0.62162567
93	MP0002429_abnormal_blood_cell	0.61944909
94	MP0006138_congestive_heart_failure	0.61810128
95	MP0005501_abnormal_skin_physiology	0.61528607
96	MP0003942_abnormal_urinary_system	0.59776027
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.59186577
98	MP0009115_abnormal_fat_cell	0.58159913
99	MP0000266_abnormal_heart_morphology	0.58114036
100	MP0000609_abnormal_liver_physiology	0.57608953

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short middle phalanx of the 5th finger (HP:0004220)	8.72539021
2	Acanthocytosis (HP:0001927)	7.44814281
3	Polycythemia (HP:0001901)	6.70849725
4	Reticulocytosis (HP:0001923)	6.61435646
5	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.24907425
6	Poikilocytosis (HP:0004447)	5.19466849
7	Abnormality of reticulocytes (HP:0004312)	5.18174770
8	Petechiae (HP:0000967)	5.15156906
9	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	5.05733748
10	Cholecystitis (HP:0001082)	4.95364071
11	Abnormal gallbladder physiology (HP:0012438)	4.95364071
12	Broad palm (HP:0001169)	4.68389126
13	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	4.54198384
14	Truncus arteriosus (HP:0001660)	4.42277202
15	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	4.19284492
16	Short 5th finger (HP:0009237)	4.09844644
17	Hypoplastic iliac wings (HP:0002866)	3.89088467
18	Hyperthyroidism (HP:0000836)	3.85847242
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.81471344
20	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.81286269
21	Chromsome breakage (HP:0040012)	3.78840081
22	Abnormal platelet function (HP:0011869)	3.77347492
23	Impaired platelet aggregation (HP:0003540)	3.77347492
24	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	3.74186521
25	Complete atrioventricular canal defect (HP:0001674)	3.69497850
26	Prolonged bleeding time (HP:0003010)	3.68729213
27	Protruding tongue (HP:0010808)	3.47000225
28	Brushfield spots (HP:0001088)	3.40731105
29	Small intestinal stenosis (HP:0012848)	3.33928541
30	Duodenal stenosis (HP:0100867)	3.33928541
31	Abnormality of cochlea (HP:0000375)	3.30283419
32	Nonimmune hydrops fetalis (HP:0001790)	3.24691391
33	Birth length less than 3rd percentile (HP:0003561)	3.19075840
34	Abnormality of dental color (HP:0011073)	3.14817266
35	Duplicated collecting system (HP:0000081)	2.92678320
36	Deep palmar crease (HP:0006191)	2.88615975
37	Facial hemangioma (HP:0000329)	2.87671847
38	Atrioventricular canal defect (HP:0006695)	2.86339774
39	Abnormality of homocysteine metabolism (HP:0010919)	2.85030000
40	Homocystinuria (HP:0002156)	2.85030000
41	Seborrheic dermatitis (HP:0001051)	2.80027103
42	Pallor (HP:0000980)	2.79918621
43	Ileus (HP:0002595)	2.78425640
44	Bowel incontinence (HP:0002607)	2.77557179
45	Overlapping toe (HP:0001845)	2.76089035
46	Abnormality of the renal collecting system (HP:0004742)	2.74083518
47	Abnormal large intestine physiology (HP:0012700)	2.68044172
48	Ankyloglossia (HP:0010296)	2.62192004
49	Hypertensive crisis (HP:0100735)	2.58752080
50	Hypoparathyroidism (HP:0000829)	2.56701007
51	Abnormality of the duodenum (HP:0002246)	2.51857085
52	Atelectasis (HP:0100750)	2.44664958
53	Upper limb muscle weakness (HP:0003484)	2.42305286
54	Cholelithiasis (HP:0001081)	2.41836054
55	Morphological abnormality of the inner ear (HP:0011390)	2.37916276
56	Short middle phalanx of finger (HP:0005819)	2.35832789
57	Acute myeloid leukemia (HP:0004808)	2.32384817
58	Hepatocellular necrosis (HP:0001404)	2.27342501
59	Abnormality of the tricuspid valve (HP:0001702)	2.26413649
60	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.24778336
61	Cortical dysplasia (HP:0002539)	2.24772009
62	Macrocytic anemia (HP:0001972)	2.20021927
63	Abnormality of alanine metabolism (HP:0010916)	2.19841550
64	Hyperalaninemia (HP:0003348)	2.19841550
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19841550
66	Reticulocytopenia (HP:0001896)	2.15735144
67	Abnormal gallbladder morphology (HP:0012437)	2.09620880
68	Microtia (HP:0008551)	2.02015808
69	Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)	2.00154034
70	Myelodysplasia (HP:0002863)	1.98605873
71	Hypoplastic ilia (HP:0000946)	1.97638564
72	Abnormality of glycolysis (HP:0004366)	1.97518294
73	Abnormality of DNA repair (HP:0003254)	1.96942285
74	Hepatic necrosis (HP:0002605)	1.96115692
75	Type I transferrin isoform profile (HP:0003642)	1.96088183
76	Acute necrotizing encephalopathy (HP:0006965)	1.94508533
77	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.93677612
78	Abnormally folded helix (HP:0008544)	1.91136231
79	Increased CSF lactate (HP:0002490)	1.85751300
80	Abnormality of the wing of the ilium (HP:0011867)	1.85181449
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.83817322
82	Increased serum pyruvate (HP:0003542)	1.83492674
83	Sandal gap (HP:0001852)	1.82669419
84	Abnormal number of erythroid precursors (HP:0012131)	1.81334293
85	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.78915443
86	Abnormality of the gallbladder (HP:0005264)	1.74625768
87	Cutaneous photosensitivity (HP:0000992)	1.73899957
88	Abnormality of oral frenula (HP:0000190)	1.72652153
89	Acute encephalopathy (HP:0006846)	1.71256867
90	Abnormal hemoglobin (HP:0011902)	1.68596181
91	Abnormality of the acetabulum (HP:0003170)	1.66933482
92	Abnormality of chromosome stability (HP:0003220)	1.66067014
93	Abnormality of the fingertips (HP:0001211)	1.64641854
94	Abnormality of cells of the erythroid lineage (HP:0012130)	1.64589992
95	Orthostatic hypotension (HP:0001278)	1.63406434
96	Hyperinsulinemic hypoglycemia (HP:0000825)	1.62531270
97	Ventricular fibrillation (HP:0001663)	1.60878012
98	Mitochondrial inheritance (HP:0001427)	1.59720521
99	Relative macrocephaly (HP:0004482)	1.59089707
100	Abnormality of the preputium (HP:0100587)	1.57267028

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	6.29641148
2	CDK12	5.95860842
3	RIPK4	4.07845136
4	EEF2K	3.32435497
5	ERN1	3.31430705
6	EIF2AK1	3.02800862
7	KSR2	2.73317161
8	TTK	2.65640718
9	CLK1	2.44096227
10	BMPR2	2.21556255
11	CDK8	2.16110336
12	RAF1	2.14155279
13	NTRK3	1.86670456
14	MAP3K2	1.81568850
15	PLK4	1.66699919
16	MAP3K10	1.48681642
17	MST4	1.46564559
18	NEK2	1.43336885
19	CCNB1	1.41812154
20	BMX	1.40295349
21	BRSK2	1.40254498
22	KSR1	1.40143361
23	CDC7	1.39104666
24	BRAF	1.37181324
25	AKT3	1.31930650
26	WEE1	1.30168456
27	EPHA3	1.27581122
28	CHEK2	1.18771906
29	STK4	1.14030160
30	NME1	1.12205225
31	TRPM7	1.09592712
32	DMPK	1.05385420
33	MAP3K8	1.04585907
34	BUB1	1.03972263
35	RET	1.03229352
36	ALK	1.01942654
37	ATR	0.99588733
38	CHEK1	0.95534587
39	TSSK6	0.95169097
40	FGFR4	0.94355719
41	IRAK3	0.93838449
42	NEK1	0.89968336
43	RPS6KB2	0.89227570
44	SRPK1	0.87284729
45	MAPKAPK3	0.85531218
46	SIK2	0.83932230
47	JAK2	0.83487134
48	MAPKAPK5	0.79498790
49	WNK4	0.78390745
50	MAP3K1	0.77525208
51	EPHB1	0.77080166
52	CDK7	0.76521086
53	PNCK	0.75416941
54	MAP3K13	0.68020852
55	CDK1	0.67271894
56	TAOK3	0.65925345
57	MTOR	0.65361078
58	TRIB3	0.63583891
59	STK3	0.62591542
60	CDK2	0.60854738
61	ATM	0.60742877
62	BRD4	0.58360592
63	PDPK1	0.56620455
64	BRSK1	0.55161761
65	PLK1	0.52326612
66	PRKCI	0.52006965
67	IRAK1	0.51211022
68	MAP3K7	0.49888794
69	AURKB	0.49560213
70	ICK	0.48334146
71	FGFR3	0.47906121
72	MARK3	0.47833237
73	MAP2K1	0.46672735
74	CSNK1E	0.45297785
75	JAK3	0.44920475
76	PAK1	0.44708325
77	TEC	0.44703670
78	BTK	0.44295056
79	PLK3	0.44175878
80	CDK4	0.42385723
81	PIM1	0.42283680
82	AKT1	0.40129394
83	MATK	0.39525123
84	MAPK10	0.38540433
85	MAPK3	0.38260204
86	MET	0.37346180
87	EIF2AK3	0.36860361
88	PBK	0.35588660
89	PRKD1	0.33710226
90	CSNK2A2	0.33694575
91	MAP3K4	0.33094639
92	MAPK14	0.29982118
93	PDK1	0.28895041
94	GSK3B	0.28600467
95	PRKG2	0.27724610
96	MAPK1	0.27455700
97	AURKA	0.27274958
98	IRAK4	0.27223571
99	CAMK1G	0.26666334
100	YES1	0.26501326

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.23992401
2	One carbon pool by folate_Homo sapiens_hsa00670	3.82035256
3	DNA replication_Homo sapiens_hsa03030	3.63249044
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.48106773
5	Mismatch repair_Homo sapiens_hsa03430	3.44268289
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.16613872
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.12842513
8	Homologous recombination_Homo sapiens_hsa03440	2.74742822
9	Cell cycle_Homo sapiens_hsa04110	2.73185877
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.59496040
11	RNA transport_Homo sapiens_hsa03013	2.54202252
12	Basal transcription factors_Homo sapiens_hsa03022	2.53037095
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26369883
14	Spliceosome_Homo sapiens_hsa03040	2.21953985
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.08009680
16	Pyruvate metabolism_Homo sapiens_hsa00620	1.94620214
17	RNA degradation_Homo sapiens_hsa03018	1.71978077
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.70301951
19	Base excision repair_Homo sapiens_hsa03410	1.69489719
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.64222156
21	Acute myeloid leukemia_Homo sapiens_hsa05221	1.61826965
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.53001652
23	Carbon metabolism_Homo sapiens_hsa01200	1.50279519
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.42327938
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.37550791
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.35096757
27	mTOR signaling pathway_Homo sapiens_hsa04150	1.27742925
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26703630
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.24992419
30	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.15896058
31	Olfactory transduction_Homo sapiens_hsa04740	1.09487675
32	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.09418594
33	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.08616591
34	Pentose phosphate pathway_Homo sapiens_hsa00030	1.07305437
35	Oocyte meiosis_Homo sapiens_hsa04114	1.06966305
36	Thyroid cancer_Homo sapiens_hsa05216	1.00228628
37	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.96557956
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.94788274
39	VEGF signaling pathway_Homo sapiens_hsa04370	0.92449423
40	ErbB signaling pathway_Homo sapiens_hsa04012	0.92333126
41	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.90333109
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.85043748
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83185005
44	Viral carcinogenesis_Homo sapiens_hsa05203	0.82216575
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80992379
46	Pancreatic cancer_Homo sapiens_hsa05212	0.77883500
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.77443856
48	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.74948268
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.70515603
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68655600
51	p53 signaling pathway_Homo sapiens_hsa04115	0.68629132
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.67443324
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.67176210
54	Other glycan degradation_Homo sapiens_hsa00511	0.63875271
55	Lysine degradation_Homo sapiens_hsa00310	0.60621043
56	Choline metabolism in cancer_Homo sapiens_hsa05231	0.60053172
57	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.59840260
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56346908
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55706321
60	Insulin signaling pathway_Homo sapiens_hsa04910	0.55011976
61	Hepatitis B_Homo sapiens_hsa05161	0.53717186
62	RNA polymerase_Homo sapiens_hsa03020	0.53393286
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51839345
64	Prolactin signaling pathway_Homo sapiens_hsa04917	0.51009992
65	Bladder cancer_Homo sapiens_hsa05219	0.49116045
66	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47749334
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47200556
68	Renal cell carcinoma_Homo sapiens_hsa05211	0.46469336
69	Salmonella infection_Homo sapiens_hsa05132	0.46146882
70	Ribosome_Homo sapiens_hsa03010	0.46071735
71	Prion diseases_Homo sapiens_hsa05020	0.43407713
72	Purine metabolism_Homo sapiens_hsa00230	0.42009613
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.40987370
74	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40057349
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.35007158
76	Glioma_Homo sapiens_hsa05214	0.34513379
77	Apoptosis_Homo sapiens_hsa04210	0.34321472
78	Galactose metabolism_Homo sapiens_hsa00052	0.33759309
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.33232895
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33158238
81	Huntingtons disease_Homo sapiens_hsa05016	0.30835029
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29987892
83	Shigellosis_Homo sapiens_hsa05131	0.28479514
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28435611
85	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26754244
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26469754
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.24863054
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.23979923
89	Glutathione metabolism_Homo sapiens_hsa00480	0.23540244
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.22264178
91	Herpes simplex infection_Homo sapiens_hsa05168	0.19978629
92	Metabolic pathways_Homo sapiens_hsa01100	0.19253665
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.18029603
94	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.16895958
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.16770940
96	Parkinsons disease_Homo sapiens_hsa05012	0.16067924
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.15797528
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.15352040
99	Taste transduction_Homo sapiens_hsa04742	0.15039099
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.15029537

RPL23AP47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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