ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.55484860
2	chaperone-mediated protein transport (GO:0072321)	6.01324338
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.01542594
4	ATP synthesis coupled proton transport (GO:0015986)	5.01542594
5	regulation of DNA endoreduplication (GO:0032875)	4.81619844
6	DNA deamination (GO:0045006)	4.78174273
7	response to xenobiotic stimulus (GO:0009410)	4.77754673
8	viral transcription (GO:0019083)	4.61520086
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.54557902
10	translational termination (GO:0006415)	4.45008476
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29268680
12	NADH dehydrogenase complex assembly (GO:0010257)	4.17316632
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.17316632
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.17316632
15	protein complex biogenesis (GO:0070271)	4.15980128
16	ribosomal small subunit biogenesis (GO:0042274)	4.05524286
17	behavioral response to nicotine (GO:0035095)	4.04054051
18	water-soluble vitamin biosynthetic process (GO:0042364)	4.00350245
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.93604379
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.90031511
21	cotranslational protein targeting to membrane (GO:0006613)	3.82040587
22	protein targeting to ER (GO:0045047)	3.79113105
23	ribosomal small subunit assembly (GO:0000028)	3.77708255
24	maturation of SSU-rRNA (GO:0030490)	3.73339196
25	translational elongation (GO:0006414)	3.67697632
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.62148720
27	sulfation (GO:0051923)	3.58428357
28	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.56850517
29	regulation of immunoglobulin secretion (GO:0051023)	3.52930567
30	protein localization to endoplasmic reticulum (GO:0070972)	3.52462464
31	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.51589138
32	protein polyglutamylation (GO:0018095)	3.47817977
33	cardiovascular system development (GO:0072358)	3.47715203
34	activated T cell proliferation (GO:0050798)	3.39124513
35	cell proliferation in forebrain (GO:0021846)	3.37092316
36	GTP biosynthetic process (GO:0006183)	3.34400679
37	piRNA metabolic process (GO:0034587)	3.30836166
38	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.27731355
39	cellular protein complex disassembly (GO:0043624)	3.27286117
40	electron transport chain (GO:0022900)	3.26027018
41	preassembly of GPI anchor in ER membrane (GO:0016254)	3.25741848
42	respiratory electron transport chain (GO:0022904)	3.22044650
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.21863523
44	translation (GO:0006412)	3.18337481
45	ATP biosynthetic process (GO:0006754)	3.17904420
46	translational initiation (GO:0006413)	3.17036462
47	positive regulation of defense response to virus by host (GO:0002230)	3.15562586
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.13804086
49	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.13127427
50	positive regulation of mast cell degranulation (GO:0043306)	3.13127427
51	cellular response to exogenous dsRNA (GO:0071360)	3.12736392
52	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.10501565
53	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.10185171
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.10185171
55	viral life cycle (GO:0019058)	3.09799032
56	intracellular protein transmembrane import (GO:0044743)	3.08595917
57	regulation of isotype switching to IgG isotypes (GO:0048302)	3.08026385
58	inner mitochondrial membrane organization (GO:0007007)	3.02029021
59	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.01006395
60	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.93487807
61	DNA methylation involved in gamete generation (GO:0043046)	2.91953553
62	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.91820461
63	positive regulation of mast cell activation (GO:0033005)	2.84320167
64	dentate gyrus development (GO:0021542)	2.83227954
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.81512537
66	UTP biosynthetic process (GO:0006228)	2.81241731
67	ribosomal large subunit biogenesis (GO:0042273)	2.80827017
68	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.80768333
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.80625022
70	regulation of mesoderm development (GO:2000380)	2.80522387
71	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.79406336
72	regulation of germinal center formation (GO:0002634)	2.78823555
73	cellular component biogenesis (GO:0044085)	2.78078645
74	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.76768986
75	rRNA processing (GO:0006364)	2.75207773
76	regulation of regulatory T cell differentiation (GO:0045589)	2.74080265
77	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.73002982
78	detection of light stimulus involved in visual perception (GO:0050908)	2.71842269
79	detection of light stimulus involved in sensory perception (GO:0050962)	2.71842269
80	respiratory chain complex IV assembly (GO:0008535)	2.70199387
81	rRNA metabolic process (GO:0016072)	2.70001836
82	UTP metabolic process (GO:0046051)	2.65498756
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.65024527
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64876164
85	protein targeting to mitochondrion (GO:0006626)	2.64557132
86	negative regulation of heart rate (GO:0010459)	2.63449594
87	positive regulation of cell fate commitment (GO:0010455)	2.63383778
88	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.63309055
89	grooming behavior (GO:0007625)	2.62188633
90	pseudouridine synthesis (GO:0001522)	2.61867314
91	peptidyl-histidine modification (GO:0018202)	2.61186898
92	cellular potassium ion homeostasis (GO:0030007)	2.56051546
93	GPI anchor metabolic process (GO:0006505)	2.55602775
94	interferon-gamma secretion (GO:0072643)	2.54829849
95	protein complex disassembly (GO:0043241)	2.54226971
96	ribonucleoprotein complex biogenesis (GO:0022613)	2.53113963
97	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.51780087
98	regulation of glomerulus development (GO:0090192)	2.47804207
99	ovulation cycle (GO:0042698)	2.47506589
100	hydrogen ion transmembrane transport (GO:1902600)	2.47106518

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.68809892
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.64611625
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29787098
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.10934516
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03138602
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64063495
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.63836040
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36565180
9	EWS_26573619_Chip-Seq_HEK293_Human	2.32196037
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27759493
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.23959165
12	VDR_22108803_ChIP-Seq_LS180_Human	2.09487917
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.08309985
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05387799
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.04580004
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94299362
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87857126
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84949561
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84516898
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.76235119
21	P300_19829295_ChIP-Seq_ESCs_Human	1.70908745
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70310001
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69552404
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.68401275
25	FUS_26573619_Chip-Seq_HEK293_Human	1.67029079
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.63118009
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60671237
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.57654007
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56756000
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54089894
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53461942
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53195585
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.52566577
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52552093
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52383486
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.47185410
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.41621986
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41173741
39	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36647604
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35265411
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34003491
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34003491
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.32365572
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30255033
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26175991
46	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.25817038
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25783198
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25189459
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24663134
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21777971
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19633720
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19156919
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17107319
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16776282
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15849574
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14419931
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14121606
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14121606
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.13963139
60	NCOR_22424771_ChIP-Seq_293T_Human	1.13754919
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13368308
62	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09190441
63	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.08423914
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06174267
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05984824
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05776964
67	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.04603903
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04244109
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.03526073
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03175640
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02723692
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00751396
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.00712164
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00549681
75	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99923503
76	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99861245
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98835586
78	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97267455
79	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.96959740
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96850836
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96411000
82	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.95717163
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95665775
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95490357
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.95009971
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94917192
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.94194534
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94194534
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.93894744
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.93769618
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93304424
92	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92969337
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92724744
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92614511
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.91389458
96	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90824064
97	TCF4_23295773_ChIP-Seq_U87_Human	0.90350521
98	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.89959092
99	SMRT_27268052_Chip-Seq_Bcells_Human	0.88733025
100	JUN_21703547_ChIP-Seq_K562_Human	0.88489938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.05033254
2	MP0002102_abnormal_ear_morphology	3.28531761
3	MP0009379_abnormal_foot_pigmentation	3.13161402
4	MP0002160_abnormal_reproductive_system	2.87351872
5	MP0004885_abnormal_endolymph	2.81814547
6	MP0003646_muscle_fatigue	2.56213581
7	MP0008877_abnormal_DNA_methylation	2.49909547
8	MP0002163_abnormal_gland_morphology	2.47537611
9	MP0005389_reproductive_system_phenotype	2.44120533
10	MP0006072_abnormal_retinal_apoptosis	2.14736352
11	MP0008875_abnormal_xenobiotic_pharmacok	2.11070815
12	MP0001835_abnormal_antigen_presentation	2.07632342
13	MP0004142_abnormal_muscle_tone	2.00081617
14	MP0005646_abnormal_pituitary_gland	1.98215094
15	MP0005671_abnormal_response_to	1.86402239
16	MP0000049_abnormal_middle_ear	1.86057735
17	MP0000569_abnormal_digit_pigmentation	1.70039683
18	MP0008789_abnormal_olfactory_epithelium	1.69777736
19	MP0005551_abnormal_eye_electrophysiolog	1.68198569
20	MP0001440_abnormal_grooming_behavior	1.67545437
21	MP0000613_abnormal_salivary_gland	1.66047374
22	MP0002138_abnormal_hepatobiliary_system	1.62970655
23	MP0005670_abnormal_white_adipose	1.60129727
24	MP0008872_abnormal_physiological_respon	1.53369836
25	MP0002272_abnormal_nervous_system	1.49053799
26	MP0002277_abnormal_respiratory_mucosa	1.47872945
27	MP0001919_abnormal_reproductive_system	1.45359576
28	MP0005379_endocrine/exocrine_gland_phen	1.43859403
29	MP0003011_delayed_dark_adaptation	1.43424156
30	MP0003786_premature_aging	1.43048017
31	MP0000631_abnormal_neuroendocrine_gland	1.42941098
32	MP0004147_increased_porphyrin_level	1.41972563
33	MP0001790_abnormal_immune_system	1.38831711
34	MP0005387_immune_system_phenotype	1.38831711
35	MP0002095_abnormal_skin_pigmentation	1.37535117
36	MP0004742_abnormal_vestibular_system	1.36497282
37	MP0002653_abnormal_ependyma_morphology	1.34879788
38	MP0004145_abnormal_muscle_electrophysio	1.34819341
39	MP0002184_abnormal_innervation	1.29070826
40	MP0005645_abnormal_hypothalamus_physiol	1.28822939
41	MP0001800_abnormal_humoral_immune	1.27027815
42	MP0002938_white_spotting	1.26771804
43	MP0003880_abnormal_central_pattern	1.25847043
44	MP0002837_dystrophic_cardiac_calcinosis	1.25323380
45	MP0001873_stomach_inflammation	1.22870167
46	MP0005394_taste/olfaction_phenotype	1.17389426
47	MP0005499_abnormal_olfactory_system	1.17389426
48	MP0009745_abnormal_behavioral_response	1.17313025
49	MP0001348_abnormal_lacrimal_gland	1.15814829
50	MP0002148_abnormal_hypersensitivity_rea	1.14584676
51	MP0001486_abnormal_startle_reflex	1.13429947
52	MP0003724_increased_susceptibility_to	1.13058633
53	MP0000372_irregular_coat_pigmentation	1.12482326
54	MP0001663_abnormal_digestive_system	1.12462347
55	MP0003937_abnormal_limbs/digits/tail_de	1.11752760
56	MP0005174_abnormal_tail_pigmentation	1.10760361
57	MP0004133_heterotaxia	1.05540738
58	MP0003878_abnormal_ear_physiology	1.05038359
59	MP0005377_hearing/vestibular/ear_phenot	1.05038359
60	MP0001502_abnormal_circadian_rhythm	1.03583536
61	MP0003567_abnormal_fetal_cardiomyocyte	0.99488902
62	MP0000685_abnormal_immune_system	0.98903356
63	MP0005253_abnormal_eye_physiology	0.98446816
64	MP0001485_abnormal_pinna_reflex	0.97735580
65	MP0001905_abnormal_dopamine_level	0.96036457
66	MP0003718_maternal_effect	0.95764455
67	MP0000026_abnormal_inner_ear	0.95397758
68	MP0003879_abnormal_hair_cell	0.91992539
69	MP0009250_abnormal_appendicular_skeleto	0.91794563
70	MP0003195_calcinosis	0.87502219
71	MP0005410_abnormal_fertilization	0.86319893
72	MP0003183_abnormal_peptide_metabolism	0.84946391
73	MP0002752_abnormal_somatic_nervous	0.84914351
74	MP0003283_abnormal_digestive_organ	0.84451322
75	MP0001986_abnormal_taste_sensitivity	0.83669874
76	MP0006276_abnormal_autonomic_nervous	0.83255668
77	MP0005636_abnormal_mineral_homeostasis	0.82567191
78	MP0004043_abnormal_pH_regulation	0.81735163
79	MP0009333_abnormal_splenocyte_physiolog	0.81714011
80	MP0003936_abnormal_reproductive_system	0.81422391
81	MP0002723_abnormal_immune_serum	0.76269894
82	MP0002572_abnormal_emotion/affect_behav	0.75530456
83	MP0003136_yellow_coat_color	0.74740728
84	MP0003119_abnormal_digestive_system	0.74511903
85	MP0009764_decreased_sensitivity_to	0.74321762
86	MP0003137_abnormal_impulse_conducting	0.74262090
87	MP0001765_abnormal_ion_homeostasis	0.73813658
88	MP0001970_abnormal_pain_threshold	0.73796315
89	MP0009780_abnormal_chondrocyte_physiolo	0.73790996
90	MP0002557_abnormal_social/conspecific_i	0.73687360
91	MP0002210_abnormal_sex_determination	0.73535543
92	MP0009765_abnormal_xenobiotic_induced	0.73074181
93	MP0000427_abnormal_hair_cycle	0.72770414
94	MP0006036_abnormal_mitochondrial_physio	0.72669209
95	MP0004134_abnormal_chest_morphology	0.71371948
96	MP0002876_abnormal_thyroid_physiology	0.71168671
97	MP0000678_abnormal_parathyroid_gland	0.71084595
98	MP0001968_abnormal_touch/_nociception	0.70971915
99	MP0000778_abnormal_nervous_system	0.70642921
100	MP0001963_abnormal_hearing_physiology	0.70389700

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjunctival hamartoma (HP:0100780)	5.52189634
2	Lipid accumulation in hepatocytes (HP:0006561)	4.59809964
3	Increased hepatocellular lipid droplets (HP:0006565)	3.72679574
4	Hamartoma of the eye (HP:0010568)	3.47215392
5	Stomatitis (HP:0010280)	3.46747747
6	Mitochondrial inheritance (HP:0001427)	3.41415096
7	Congenital stationary night blindness (HP:0007642)	3.28309405
8	Acute necrotizing encephalopathy (HP:0006965)	3.26503995
9	Increased CSF lactate (HP:0002490)	3.20474740
10	Pendular nystagmus (HP:0012043)	3.12759532
11	Molar tooth sign on MRI (HP:0002419)	3.06414987
12	Abnormality of midbrain morphology (HP:0002418)	3.06414987
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.03263842
14	Pancreatic cysts (HP:0001737)	2.97579725
15	Increased muscle lipid content (HP:0009058)	2.97291076
16	Reticulocytopenia (HP:0001896)	2.96951894
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.95971962
18	Renal Fanconi syndrome (HP:0001994)	2.95923784
19	Meningioma (HP:0002858)	2.93570420
20	Progressive macrocephaly (HP:0004481)	2.91182398
21	Pancreatic fibrosis (HP:0100732)	2.85803114
22	Colon cancer (HP:0003003)	2.85493488
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79037434
24	Acute encephalopathy (HP:0006846)	2.78884139
25	Furrowed tongue (HP:0000221)	2.72179464
26	Hypoplasia of the uterus (HP:0000013)	2.70646031
27	Abnormal number of erythroid precursors (HP:0012131)	2.68260598
28	IgG deficiency (HP:0004315)	2.68139104
29	Hypoplasia of the ulna (HP:0003022)	2.67102159
30	Abolished electroretinogram (ERG) (HP:0000550)	2.65273282
31	Hepatocellular necrosis (HP:0001404)	2.64835860
32	Methylmalonic acidemia (HP:0002912)	2.60853113
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.60809768
34	Abnormality of renal resorption (HP:0011038)	2.59289947
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.58811224
36	Mesomelia (HP:0003027)	2.56106387
37	Asplenia (HP:0001746)	2.54728463
38	Increased intramyocellular lipid droplets (HP:0012240)	2.52054745
39	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.49619383
40	True hermaphroditism (HP:0010459)	2.46195147
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45478302
42	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.44473012
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.40660046
44	Short femoral neck (HP:0100864)	2.38612341
45	Progressive inability to walk (HP:0002505)	2.35712284
46	Methylmalonic aciduria (HP:0012120)	2.33516492
47	Exertional dyspnea (HP:0002875)	2.33105712
48	Bone cyst (HP:0012062)	2.31913942
49	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.29704510
50	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29572271
51	Cavernous hemangioma (HP:0001048)	2.28559930
52	Nephronophthisis (HP:0000090)	2.23963596
53	Congenital, generalized hypertrichosis (HP:0004540)	2.23897607
54	Adenoma sebaceum (HP:0009720)	2.22566535
55	Angiofibromas (HP:0010615)	2.22566535
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21546256
57	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21546256
58	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.18332023
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17707605
60	Goiter (HP:0000853)	2.16304712
61	Pallor (HP:0000980)	2.15322883
62	Radial bowing (HP:0002986)	2.13455171
63	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.11059978
64	Keratoconus (HP:0000563)	2.10662481
65	Increased corneal curvature (HP:0100692)	2.10662481
66	Forearm undergrowth (HP:0009821)	2.09952899
67	Hepatic necrosis (HP:0002605)	2.09226039
68	Hypoplasia of the radius (HP:0002984)	2.09111687
69	Melanoma (HP:0002861)	2.09054540
70	Optic disc pallor (HP:0000543)	2.07892661
71	Short tibia (HP:0005736)	2.04557426
72	Severe visual impairment (HP:0001141)	2.04307900
73	Abnormality of DNA repair (HP:0003254)	2.00293670
74	Papilledema (HP:0001085)	1.97926898
75	Absent/shortened dynein arms (HP:0200106)	1.97893074
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97893074
77	Macrocytic anemia (HP:0001972)	1.97793386
78	Short 4th metacarpal (HP:0010044)	1.97605380
79	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.97605380
80	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.97575055
81	Stenosis of the external auditory canal (HP:0000402)	1.96530097
82	Septo-optic dysplasia (HP:0100842)	1.94823488
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94612530
84	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.94557611
85	Abnormal drinking behavior (HP:0030082)	1.93245610
86	Polydipsia (HP:0001959)	1.93245610
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92643028
88	Fibular aplasia (HP:0002990)	1.91875920
89	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91631314
90	Abnormality of the nasal septum (HP:0000419)	1.90235402
91	Neoplasm of the adrenal cortex (HP:0100641)	1.89404589
92	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.89310734
93	Elevated erythrocyte sedimentation rate (HP:0003565)	1.89169126
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.88808071
95	Decreased central vision (HP:0007663)	1.87510707
96	Cerebral edema (HP:0002181)	1.87465521
97	Absent thumb (HP:0009777)	1.87142317
98	Bulbous nose (HP:0000414)	1.85263755
99	Increased serum lactate (HP:0002151)	1.82546164
100	Adrenal hypoplasia (HP:0000835)	1.81596207

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	6.01614762
2	NUAK1	3.68461334
3	TLK1	3.31418270
4	WNK4	2.96244925
5	TAF1	2.86323974
6	ADRBK2	2.58901722
7	STK16	2.48591956
8	VRK2	2.41530720
9	TXK	2.37198504
10	DYRK2	2.16272278
11	STK39	1.99515181
12	FRK	1.93008651
13	GRK1	1.91051069
14	CDK19	1.71761628
15	ZAK	1.64779220
16	MAP2K6	1.57116471
17	TAOK3	1.48381398
18	BMPR1B	1.47512421
19	WNK3	1.45451303
20	NLK	1.39678872
21	BCKDK	1.35491942
22	MAP4K2	1.34378568
23	MST4	1.33820929
24	CSNK1A1L	1.27660013
25	BMPR2	1.27139313
26	PINK1	1.22144917
27	CSNK1G3	1.14706110
28	WNK1	1.10010000
29	IKBKB	1.04167690
30	CSNK1G2	1.02230418
31	MAP3K12	1.01826332
32	PHKG2	1.01226975
33	PHKG1	1.01226975
34	TEC	1.01113624
35	MAP4K1	0.99334787
36	MAP2K2	0.98753585
37	MELK	0.97155080
38	OXSR1	0.96971282
39	DAPK3	0.95044410
40	TNIK	0.95043989
41	CASK	0.94468409
42	VRK1	0.93881611
43	NEK1	0.91457103
44	NEK9	0.90889411
45	STK11	0.89782941
46	ADRBK1	0.87571471
47	CSNK1G1	0.85711274
48	GRK7	0.83106270
49	DAPK2	0.80059036
50	IKBKE	0.74035028
51	ERN1	0.73262320
52	SIK2	0.71699784
53	MAPKAPK5	0.70732117
54	MUSK	0.67294009
55	GRK5	0.65730787
56	NEK2	0.63440458
57	TIE1	0.62134631
58	NTRK2	0.62076711
59	EIF2AK1	0.62054992
60	EPHB2	0.60926967
61	DMPK	0.60181762
62	MYLK	0.58028771
63	EIF2AK2	0.56409822
64	PRKCQ	0.55235833
65	PAK3	0.54569990
66	RPS6KB1	0.54506969
67	PRKCG	0.54467684
68	PLK2	0.54364760
69	DAPK1	0.52420976
70	PRKACA	0.52313938
71	PLK3	0.51962120
72	INSRR	0.51923478
73	CSNK1A1	0.50030536
74	EIF2AK3	0.49032156
75	SYK	0.48542431
76	BUB1	0.48265151
77	CSNK2A1	0.47267354
78	PIM1	0.45572098
79	RPS6KA5	0.44479377
80	MAPK13	0.44046610
81	CSNK2A2	0.41087926
82	ITK	0.40572881
83	CSNK1D	0.40436048
84	LATS1	0.39251157
85	PRKCE	0.39013423
86	MARK3	0.38181272
87	PBK	0.36517721
88	PTK2B	0.36075652
89	TSSK6	0.35728743
90	ABL1	0.34849727
91	KIT	0.34605944
92	PRKG1	0.33961329
93	CHUK	0.32638428
94	MKNK1	0.31538508
95	PRKACG	0.30413401
96	CSNK1E	0.29890819
97	BTK	0.29881750
98	RPS6KA6	0.29362119
99	SGK2	0.28891853
100	AKT3	0.28739613

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.70362756
2	Ribosome_Homo sapiens_hsa03010	4.31095129
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49694095
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.30700153
5	Allograft rejection_Homo sapiens_hsa05330	3.03161849
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.89431637
7	Parkinsons disease_Homo sapiens_hsa05012	2.83200990
8	Protein export_Homo sapiens_hsa03060	2.69488620
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.41822252
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19889066
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.12277080
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.09495857
13	Basal transcription factors_Homo sapiens_hsa03022	1.98549728
14	Alzheimers disease_Homo sapiens_hsa05010	1.93790760
15	Phototransduction_Homo sapiens_hsa04744	1.93768252
16	Proteasome_Homo sapiens_hsa03050	1.91079567
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88827227
18	Huntingtons disease_Homo sapiens_hsa05016	1.88650035
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.79625464
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73353141
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69331521
22	Caffeine metabolism_Homo sapiens_hsa00232	1.62389919
23	RNA polymerase_Homo sapiens_hsa03020	1.58318107
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53220120
25	Homologous recombination_Homo sapiens_hsa03440	1.37064073
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28982392
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28541122
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.27559853
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.25864229
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.23759145
31	One carbon pool by folate_Homo sapiens_hsa00670	1.21696158
32	RNA degradation_Homo sapiens_hsa03018	1.19226968
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14575586
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12839240
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.11264895
36	Viral myocarditis_Homo sapiens_hsa05416	1.07425904
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.06416361
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.05220087
39	Sulfur relay system_Homo sapiens_hsa04122	1.04728560
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04515819
41	Nicotine addiction_Homo sapiens_hsa05033	0.99883986
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99863207
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92079259
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91177316
45	Sulfur metabolism_Homo sapiens_hsa00920	0.81130692
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75217056
47	Olfactory transduction_Homo sapiens_hsa04740	0.75009416
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70844781
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68989741
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67204730
51	Retinol metabolism_Homo sapiens_hsa00830	0.66582211
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65677340
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.63995029
54	Morphine addiction_Homo sapiens_hsa05032	0.62587867
55	RNA transport_Homo sapiens_hsa03013	0.62508692
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61178300
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60360095
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60081787
59	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.59449214
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.58164553
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55029946
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53704536
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.52912775
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48858748
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48530370
66	Propanoate metabolism_Homo sapiens_hsa00640	0.46948702
67	Insulin secretion_Homo sapiens_hsa04911	0.46568467
68	Purine metabolism_Homo sapiens_hsa00230	0.45369924
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.45170085
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42439789
71	Serotonergic synapse_Homo sapiens_hsa04726	0.41563913
72	Melanoma_Homo sapiens_hsa05218	0.40830055
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38926577
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38573540
75	Mismatch repair_Homo sapiens_hsa03430	0.38226663
76	Spliceosome_Homo sapiens_hsa03040	0.38002974
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36110226
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35498990
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34302299
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33488443
81	Taste transduction_Homo sapiens_hsa04742	0.32677290
82	GABAergic synapse_Homo sapiens_hsa04727	0.32377866
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31941906
84	Metabolic pathways_Homo sapiens_hsa01100	0.31626350
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31455072
86	Peroxisome_Homo sapiens_hsa04146	0.30320044
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29889965
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29314878
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29141300
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21866423
91	Herpes simplex infection_Homo sapiens_hsa05168	0.21836154
92	Salivary secretion_Homo sapiens_hsa04970	0.21760818
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.19810665
94	Mineral absorption_Homo sapiens_hsa04978	0.19571705
95	Selenocompound metabolism_Homo sapiens_hsa00450	0.19279312
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.19213401
97	Gastric acid secretion_Homo sapiens_hsa04971	0.19140994
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.18872748
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17939268
100	Leishmaniasis_Homo sapiens_hsa05140	0.17487677

RPL23AP48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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