ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.53659154
2	neutrophil activation involved in immune response (GO:0002283)	5.78793866
3	ribosomal small subunit assembly (GO:0000028)	5.47936395
4	interkinetic nuclear migration (GO:0022027)	5.47531172
5	preassembly of GPI anchor in ER membrane (GO:0016254)	5.43160866
6	maternal behavior (GO:0042711)	4.97802885
7	parental behavior (GO:0060746)	4.95048110
8	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.62599795
9	aggressive behavior (GO:0002118)	4.47964502
10	cellular ketone body metabolic process (GO:0046950)	4.35063046
11	GPI anchor biosynthetic process (GO:0006506)	4.34597210
12	platelet dense granule organization (GO:0060155)	4.31041029
13	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.24016035
14	forebrain morphogenesis (GO:0048853)	4.13467555
15	tyrosine phosphorylation of STAT protein (GO:0007260)	4.06098476
16	ubiquinone biosynthetic process (GO:0006744)	3.95813209
17	protein complex biogenesis (GO:0070271)	3.91728613
18	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.90940097
19	ketone body metabolic process (GO:1902224)	3.83914584
20	GPI anchor metabolic process (GO:0006505)	3.79070077
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.78293492
22	negative regulation of heart rate (GO:0010459)	3.77928182
23	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.71893261
24	C-terminal protein lipidation (GO:0006501)	3.67003552
25	poly(A)+ mRNA export from nucleus (GO:0016973)	3.66402728
26	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.65614274
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57740084
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57740084
29	NADH dehydrogenase complex assembly (GO:0010257)	3.57740084
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56635068
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.56515713
32	ATP synthesis coupled proton transport (GO:0015986)	3.56515713
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53901637
34	definitive hemopoiesis (GO:0060216)	3.52424409
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.50091246
36	viral transcription (GO:0019083)	3.48787760
37	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.47180043
38	ubiquinone metabolic process (GO:0006743)	3.45390618
39	primitive streak formation (GO:0090009)	3.44671854
40	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.38204299
41	translational termination (GO:0006415)	3.34631043
42	aldehyde catabolic process (GO:0046185)	3.33598131
43	cullin deneddylation (GO:0010388)	3.32261460
44	C-terminal protein amino acid modification (GO:0018410)	3.23823525
45	quinone biosynthetic process (GO:1901663)	3.10916328
46	multicellular organismal reproductive behavior (GO:0033057)	3.08097391
47	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.07333147
48	synapsis (GO:0007129)	3.07173238
49	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.06468504
50	substrate-dependent cell migration (GO:0006929)	3.05151706
51	gonadal mesoderm development (GO:0007506)	3.03442021
52	base-excision repair, AP site formation (GO:0006285)	3.01926834
53	seminiferous tubule development (GO:0072520)	3.00722532
54	protein localization to endoplasmic reticulum (GO:0070972)	3.00260842
55	cotranslational protein targeting to membrane (GO:0006613)	2.99440232
56	metallo-sulfur cluster assembly (GO:0031163)	2.99062855
57	iron-sulfur cluster assembly (GO:0016226)	2.99062855
58	retinal cone cell development (GO:0046549)	2.98361178
59	vesicle targeting (GO:0006903)	2.97314966
60	morphogenesis of embryonic epithelium (GO:0016331)	2.96880345
61	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.96792025
62	protein targeting to ER (GO:0045047)	2.94655623
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.93880986
64	pyrimidine nucleotide catabolic process (GO:0006244)	2.93535330
65	induction of positive chemotaxis (GO:0050930)	2.91378190
66	thrombin receptor signaling pathway (GO:0070493)	2.91357977
67	synaptic vesicle exocytosis (GO:0016079)	2.90860064
68	maturation of SSU-rRNA (GO:0030490)	2.86601072
69	respiratory electron transport chain (GO:0022904)	2.86497105
70	negative regulation of heart contraction (GO:0045822)	2.85857428
71	lipoxygenase pathway (GO:0019372)	2.85188034
72	translational elongation (GO:0006414)	2.83774315
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.83581421
74	deoxyribonucleotide catabolic process (GO:0009264)	2.83425097
75	electron transport chain (GO:0022900)	2.83307272
76	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.82959803
77	ribosomal large subunit biogenesis (GO:0042273)	2.78083587
78	ribosomal small subunit biogenesis (GO:0042274)	2.77425883
79	deoxyribose phosphate biosynthetic process (GO:0046385)	2.76036344
80	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.76036344
81	superoxide anion generation (GO:0042554)	2.75112975
82	respiratory chain complex IV assembly (GO:0008535)	2.74628391
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72287225
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72287225
85	mannosylation (GO:0097502)	2.71498805
86	DNA deamination (GO:0045006)	2.71368848
87	protein deneddylation (GO:0000338)	2.71142479
88	synaptic transmission, dopaminergic (GO:0001963)	2.70159246
89	proteasome assembly (GO:0043248)	2.68511514
90	ATP hydrolysis coupled proton transport (GO:0015991)	2.66288549
91	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.66288549
92	positive regulation of TOR signaling (GO:0032008)	2.65318203
93	regulation of pigment cell differentiation (GO:0050932)	2.65045980
94	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.62372687
95	L-phenylalanine catabolic process (GO:0006559)	2.62372687
96	hepatocyte differentiation (GO:0070365)	2.62147915
97	protein maturation by protein folding (GO:0022417)	2.61454155
98	short-chain fatty acid metabolic process (GO:0046459)	2.59409809
99	cellular protein complex disassembly (GO:0043624)	2.59290236
100	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.58540145

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	3.91197668
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.58955504
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.93544872
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84374942
5	VDR_22108803_ChIP-Seq_LS180_Human	2.58649726
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.51785845
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48448364
8	MYC_18940864_ChIP-ChIP_HL60_Human	2.47541597
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38040393
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32823813
11	EWS_26573619_Chip-Seq_HEK293_Human	2.29254324
12	FUS_26573619_Chip-Seq_HEK293_Human	2.17757453
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.11594100
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98123890
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.97171341
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.96567676
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.95102937
18	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.94141029
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93088224
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92668139
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.89603661
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.88762546
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.77589835
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70855443
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66857087
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61841387
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56900137
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51009032
29	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.50472863
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.48443095
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.48350075
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47364472
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.44356368
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.41354655
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39916682
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38511511
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38203723
38	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38101259
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.36150894
40	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.35925665
41	P300_19829295_ChIP-Seq_ESCs_Human	1.35215298
42	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33584159
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.32770604
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.30330288
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29404878
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25319733
47	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24184073
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23303166
49	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22651868
50	AR_20517297_ChIP-Seq_VCAP_Human	1.21761956
51	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.20697397
52	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.20253505
53	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.20253505
54	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.20253505
55	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.19850481
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18120232
57	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15017754
58	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.14797982
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10015519
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10015519
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09485882
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08178578
63	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.07984670
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.07805002
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07565534
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05379815
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04749064
68	P53_21459846_ChIP-Seq_SAOS-2_Human	1.04457918
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04137691
70	NCOR_22424771_ChIP-Seq_293T_Human	1.03653960
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03034995
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.02797067
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01802881
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01552576
75	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01050599
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00979974
77	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.00854606
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.00142849
79	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96800154
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96727197
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96706810
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96706810
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96257031
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96039915
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93360479
86	SMAD4_21799915_ChIP-Seq_A2780_Human	0.92579014
87	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92289342
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91837179
89	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.91694395
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91685932
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90608525
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89846633
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.88802833
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.88767397
95	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.88683596
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86040043
97	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.85975349
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85763306
99	EOMES_21245162_ChIP-Seq_HESCs_Human	0.84450154
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.84290552

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.29472214
2	MP0010368_abnormal_lymphatic_system	6.51066551
3	MP0006292_abnormal_olfactory_placode	4.76307514
4	MP0002163_abnormal_gland_morphology	3.85880627
5	MP0005084_abnormal_gallbladder_morpholo	3.61288200
6	MP0001879_abnormal_lymphatic_vessel	3.52543349
7	MP0005464_abnormal_platelet_physiology	3.32618903
8	MP0001545_abnormal_hematopoietic_system	2.75612286
9	MP0005397_hematopoietic_system_phenotyp	2.75612286
10	MP0005646_abnormal_pituitary_gland	2.59052849
11	MP0005174_abnormal_tail_pigmentation	2.43217591
12	MP0001188_hyperpigmentation	2.14934654
13	MP0005379_endocrine/exocrine_gland_phen	2.01020858
14	MP0000516_abnormal_urinary_system	1.98973852
15	MP0005367_renal/urinary_system_phenotyp	1.98973852
16	MP0005409_darkened_coat_color	1.94315127
17	MP0006036_abnormal_mitochondrial_physio	1.92910614
18	MP0000015_abnormal_ear_pigmentation	1.86273016
19	MP0002928_abnormal_bile_duct	1.78778021
20	MP0001968_abnormal_touch/_nociception	1.71369777
21	MP0002822_catalepsy	1.63288275
22	MP0003186_abnormal_redox_activity	1.54480781
23	MP0002095_abnormal_skin_pigmentation	1.53602099
24	MP0009764_decreased_sensitivity_to	1.48190324
25	MP0008004_abnormal_stomach_pH	1.47418904
26	MP0008877_abnormal_DNA_methylation	1.46711733
27	MP0002837_dystrophic_cardiac_calcinosis	1.46003477
28	MP0000372_irregular_coat_pigmentation	1.42260427
29	MP0003011_delayed_dark_adaptation	1.36532251
30	MP0004885_abnormal_endolymph	1.35683614
31	MP0008872_abnormal_physiological_respon	1.34250593
32	MP0002736_abnormal_nociception_after	1.33227341
33	MP0005551_abnormal_eye_electrophysiolog	1.31264095
34	MP0002938_white_spotting	1.28412226
35	MP0005410_abnormal_fertilization	1.27260689
36	MP0006035_abnormal_mitochondrial_morpho	1.25620999
37	MP0006276_abnormal_autonomic_nervous	1.24622065
38	MP0000230_abnormal_systemic_arterial	1.24469020
39	MP0002653_abnormal_ependyma_morphology	1.24345468
40	MP0004215_abnormal_myocardial_fiber	1.23334538
41	MP0001661_extended_life_span	1.20800558
42	MP0005167_abnormal_blood-brain_barrier	1.18594656
43	MP0006072_abnormal_retinal_apoptosis	1.15468386
44	MP0002272_abnormal_nervous_system	1.14992657
45	MP0008058_abnormal_DNA_repair	1.13300600
46	MP0000681_abnormal_thyroid_gland	1.07764401
47	MP0005645_abnormal_hypothalamus_physiol	1.05918220
48	MP0009697_abnormal_copulation	1.00567247
49	MP0002160_abnormal_reproductive_system	0.97701039
50	MP0004484_altered_response_of	0.95484934
51	MP0005670_abnormal_white_adipose	0.95031384
52	MP0008775_abnormal_heart_ventricle	0.93963515
53	MP0009046_muscle_twitch	0.93781026
54	MP0000049_abnormal_middle_ear	0.90078654
55	MP0002102_abnormal_ear_morphology	0.88907873
56	MP0001905_abnormal_dopamine_level	0.88867467
57	MP0005083_abnormal_biliary_tract	0.88358431
58	MP0003315_abnormal_perineum_morphology	0.88200182
59	MP0003718_maternal_effect	0.87063394
60	MP0006138_congestive_heart_failure	0.79778975
61	MP0005075_abnormal_melanosome_morpholog	0.77496326
62	MP0002132_abnormal_respiratory_system	0.76704223
63	MP0008057_abnormal_DNA_replication	0.76320186
64	MP0003693_abnormal_embryo_hatching	0.75515102
65	MP0005389_reproductive_system_phenotype	0.75337952
66	MP0003183_abnormal_peptide_metabolism	0.75321633
67	MP0008995_early_reproductive_senescence	0.73096531
68	MP0003880_abnormal_central_pattern	0.72738783
69	MP0001929_abnormal_gametogenesis	0.69015597
70	MP0002733_abnormal_thermal_nociception	0.67996279
71	MP0003252_abnormal_bile_duct	0.66615146
72	MP0002876_abnormal_thyroid_physiology	0.65517502
73	MP0002148_abnormal_hypersensitivity_rea	0.64881147
74	MP0003698_abnormal_male_reproductive	0.62682881
75	MP0005636_abnormal_mineral_homeostasis	0.62528612
76	MP0004084_abnormal_cardiac_muscle	0.61929334
77	MP0001756_abnormal_urination	0.61603343
78	MP0000631_abnormal_neuroendocrine_gland	0.61416202
79	MP0004142_abnormal_muscle_tone	0.59381283
80	MP0005330_cardiomyopathy	0.59233793
81	MP0008932_abnormal_embryonic_tissue	0.58515656
82	MP0002557_abnormal_social/conspecific_i	0.58281833
83	MP0010386_abnormal_urinary_bladder	0.58179872
84	MP0008789_abnormal_olfactory_epithelium	0.57749928
85	MP0002075_abnormal_coat/hair_pigmentati	0.57249285
86	MP0005332_abnormal_amino_acid	0.57128464
87	MP0005647_abnormal_sex_gland	0.56907236
88	MP0005253_abnormal_eye_physiology	0.56679896
89	MP0003787_abnormal_imprinting	0.56454843
90	MP0004742_abnormal_vestibular_system	0.55904746
91	MP0005085_abnormal_gallbladder_physiolo	0.55744808
92	MP0000465_gastrointestinal_hemorrhage	0.55467424
93	MP0004036_abnormal_muscle_relaxation	0.55058495
94	MP0002177_abnormal_outer_ear	0.54702825
95	MP0004134_abnormal_chest_morphology	0.53617755
96	MP0001293_anophthalmia	0.52583577
97	MP0000343_altered_response_to	0.50298629
98	MP0001784_abnormal_fluid_regulation	0.50151258
99	MP0004808_abnormal_hematopoietic_stem	0.48631070
100	MP0001970_abnormal_pain_threshold	0.48579881

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjunctival telangiectasia (HP:0000524)	4.24573353
2	Abnormality of the anterior horn cell (HP:0006802)	4.16386388
3	Degeneration of anterior horn cells (HP:0002398)	4.16386388
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.06051048
5	Acute necrotizing encephalopathy (HP:0006965)	3.99145902
6	Petechiae (HP:0000967)	3.92366710
7	Prolonged bleeding time (HP:0003010)	3.80391965
8	Acute encephalopathy (HP:0006846)	3.72824435
9	Exertional dyspnea (HP:0002875)	3.69421665
10	Hepatic necrosis (HP:0002605)	3.55994510
11	Choroideremia (HP:0001139)	3.55069442
12	Abnormality of the vasculature of the conjunctiva (HP:0008054)	3.52082818
13	Mitochondrial inheritance (HP:0001427)	3.47926140
14	Hepatocellular necrosis (HP:0001404)	3.45921647
15	Febrile seizures (HP:0002373)	3.45921362
16	Atonic seizures (HP:0010819)	3.37726315
17	Progressive macrocephaly (HP:0004481)	3.31849975
18	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.26205598
19	Decreased central vision (HP:0007663)	3.24120126
20	Abnormality of lateral ventricle (HP:0030047)	3.23374564
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.12546796
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.12546796
23	Abnormal protein glycosylation (HP:0012346)	3.10441838
24	Abnormal glycosylation (HP:0012345)	3.10441838
25	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.10441838
26	Abnormal protein N-linked glycosylation (HP:0012347)	3.10441838
27	Spontaneous abortion (HP:0005268)	3.07923667
28	Hyperglycinemia (HP:0002154)	3.01714612
29	Failure to thrive in infancy (HP:0001531)	2.96256910
30	Dyschromatopsia (HP:0007641)	2.95568614
31	Stenosis of the external auditory canal (HP:0000402)	2.91616234
32	Increased CSF lactate (HP:0002490)	2.90909589
33	Facial hemangioma (HP:0000329)	2.89586816
34	Abnormality of cells of the erythroid lineage (HP:0012130)	2.88911384
35	Abnormal number of erythroid precursors (HP:0012131)	2.86345335
36	3-Methylglutaconic aciduria (HP:0003535)	2.85587814
37	Type II lissencephaly (HP:0007260)	2.77145818
38	Hyperlipoproteinemia (HP:0010980)	2.75771909
39	Renal Fanconi syndrome (HP:0001994)	2.67400730
40	Increased mean platelet volume (HP:0011877)	2.66618889
41	Increased intramyocellular lipid droplets (HP:0012240)	2.62423545
42	Epistaxis (HP:0000421)	2.62173245
43	Abolished electroretinogram (ERG) (HP:0000550)	2.52242690
44	Cerebral edema (HP:0002181)	2.44070584
45	Myokymia (HP:0002411)	2.43960119
46	Menorrhagia (HP:0000132)	2.42313764
47	Thrombocytosis (HP:0001894)	2.37031252
48	Ketosis (HP:0001946)	2.35091438
49	Poikilocytosis (HP:0004447)	2.33784424
50	Acute hepatic failure (HP:0006554)	2.31917707
51	Pendular nystagmus (HP:0012043)	2.30541314
52	Hyperglycinuria (HP:0003108)	2.28116866
53	Acanthocytosis (HP:0001927)	2.27048024
54	Increased muscle lipid content (HP:0009058)	2.27023033
55	Abnormality of macular pigmentation (HP:0008002)	2.26893232
56	Abnormal platelet volume (HP:0011876)	2.26033979
57	Type I transferrin isoform profile (HP:0003642)	2.22558137
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21371225
59	Ketoacidosis (HP:0001993)	2.21358104
60	Heterochromia iridis (HP:0001100)	2.19049227
61	Reduced antithrombin III activity (HP:0001976)	2.15148025
62	Abnormal platelet function (HP:0011869)	2.14003410
63	Impaired platelet aggregation (HP:0003540)	2.14003410
64	Stillbirth (HP:0003826)	2.13805150
65	Methylmalonic acidemia (HP:0002912)	2.13199086
66	Abnormal hemoglobin (HP:0011902)	2.13040523
67	Optic disc pallor (HP:0000543)	2.12551367
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10700894
69	Central scotoma (HP:0000603)	2.09403164
70	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.09285945
71	Purpura (HP:0000979)	2.09069041
72	Generalized aminoaciduria (HP:0002909)	2.08299863
73	Lipid accumulation in hepatocytes (HP:0006561)	2.07799344
74	Abnormality of the lower motor neuron (HP:0002366)	2.07501530
75	Abnormality of serine family amino acid metabolism (HP:0010894)	2.07118735
76	Abnormality of glycine metabolism (HP:0010895)	2.07118735
77	True hermaphroditism (HP:0010459)	2.06768983
78	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.06447716
79	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.05954454
80	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.03243663
81	Dicarboxylic aciduria (HP:0003215)	2.03243663
82	Reticulocytopenia (HP:0001896)	2.02959227
83	Short middle phalanx of the 5th finger (HP:0004220)	2.02413372
84	Molar tooth sign on MRI (HP:0002419)	2.02383559
85	Abnormality of midbrain morphology (HP:0002418)	2.02383559
86	Gingival bleeding (HP:0000225)	2.01914392
87	Exercise intolerance (HP:0003546)	2.00678092
88	Increased hepatocellular lipid droplets (HP:0006565)	1.99573185
89	Lactic acidosis (HP:0003128)	1.99055385
90	Congenital stationary night blindness (HP:0007642)	1.98777582
91	Colon cancer (HP:0003003)	1.98504803
92	Congenital, generalized hypertrichosis (HP:0004540)	1.95617728
93	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.95566027
94	Increased serum lactate (HP:0002151)	1.92168453
95	Absent phalangeal crease (HP:0006109)	1.91986863
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.91385209
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91385209
98	Cerebellar dysplasia (HP:0007033)	1.89337075
99	Lethargy (HP:0001254)	1.87120140
100	Pallor (HP:0000980)	1.86795464

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	6.98861651
2	ZAK	4.09421334
3	MAP4K2	3.70626512
4	MAP3K13	3.61136837
5	MAP3K12	3.59624693
6	STK38L	3.09130398
7	TEC	2.54812970
8	VRK2	2.47967671
9	STK24	2.11525393
10	MYLK	2.07854684
11	BCKDK	1.99832343
12	TAOK3	1.83024285
13	TRIM28	1.63754732
14	GRK5	1.60469950
15	BCR	1.56597031
16	ARAF	1.47606117
17	STK16	1.44724102
18	ADRBK2	1.41927489
19	MST4	1.39202228
20	TNIK	1.30034754
21	STK3	1.28359001
22	MAP2K4	1.26123026
23	FRK	1.24300345
24	PIM2	1.21003963
25	PIK3CG	1.20430956
26	LIMK1	1.18152967
27	CDK19	1.13155978
28	NUAK1	1.12804942
29	ILK	1.10138928
30	BMPR1B	1.08146055
31	DAPK3	1.06793606
32	NME2	1.00444669
33	VRK1	0.97943934
34	MAP3K5	0.96443208
35	GRK1	0.96292366
36	TAF1	0.95865201
37	MAP2K3	0.94101076
38	SRPK1	0.93472401
39	NEK9	0.91064959
40	WNK3	0.81997309
41	DAPK1	0.80263728
42	MAP3K11	0.79864146
43	ATR	0.76399515
44	PINK1	0.73270890
45	CSNK1G3	0.72759276
46	CSF1R	0.70906514
47	KIT	0.69954367
48	CCNB1	0.68467122
49	DAPK2	0.66900608
50	IKBKB	0.66792365
51	TLK1	0.66570822
52	BMX	0.66339775
53	PLK2	0.62330313
54	PKN1	0.61091370
55	PLK3	0.59533936
56	KDR	0.56759317
57	DYRK2	0.53590207
58	JAK3	0.53028365
59	INSRR	0.52927384
60	CSNK1G1	0.52137162
61	ADRBK1	0.52113150
62	PRKCQ	0.51648784
63	TESK1	0.51292117
64	PAK3	0.50014517
65	MATK	0.49937044
66	CSNK1G2	0.49739520
67	TTK	0.48117567
68	OBSCN	0.47695840
69	MAP2K7	0.46355817
70	EPHB2	0.44700027
71	CDK8	0.44447454
72	IGF1R	0.44224630
73	PLK1	0.43477017
74	ACVR1B	0.43083414
75	ABL2	0.40843267
76	PTK2B	0.40708208
77	CLK1	0.39947285
78	MAP2K6	0.39008644
79	FLT3	0.38581859
80	SCYL2	0.37994737
81	PRKCA	0.37849408
82	PAK2	0.37237786
83	BTK	0.35935582
84	TXK	0.34344285
85	TGFBR1	0.34267016
86	CSNK1A1L	0.33947413
87	PLK4	0.33628236
88	AURKA	0.33139137
89	MAPK13	0.33065558
90	PRKACA	0.31907833
91	RPS6KA5	0.31699188
92	PRKCG	0.30807633
93	EPHA4	0.29833014
94	WNK4	0.29450581
95	LMTK2	0.28773963
96	SYK	0.28700644
97	PBK	0.27457332
98	MOS	0.27335727
99	ROCK1	0.26792560
100	CDC7	0.26360426

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.01262367
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.61368872
3	Ribosome_Homo sapiens_hsa03010	3.42772964
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.23012550
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	3.17836159
6	Parkinsons disease_Homo sapiens_hsa05012	2.85833958
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.43268221
8	Huntingtons disease_Homo sapiens_hsa05016	2.05324962
9	Alzheimers disease_Homo sapiens_hsa05010	1.99654731
10	RNA polymerase_Homo sapiens_hsa03020	1.90592562
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89298232
12	Butanoate metabolism_Homo sapiens_hsa00650	1.82100050
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.80637885
14	Homologous recombination_Homo sapiens_hsa03440	1.80262239
15	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.78128416
16	Proteasome_Homo sapiens_hsa03050	1.75589395
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71135937
18	Fatty acid elongation_Homo sapiens_hsa00062	1.69541030
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.67715007
20	Mismatch repair_Homo sapiens_hsa03430	1.60112950
21	Protein export_Homo sapiens_hsa03060	1.52118560
22	Basal transcription factors_Homo sapiens_hsa03022	1.51217982
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.48183946
24	Sulfur metabolism_Homo sapiens_hsa00920	1.46147463
25	Peroxisome_Homo sapiens_hsa04146	1.38051035
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.37065235
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.33606897
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32255392
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29374958
30	Propanoate metabolism_Homo sapiens_hsa00640	1.26701424
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16122287
32	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.15258298
33	Regulation of autophagy_Homo sapiens_hsa04140	1.14487555
34	Fatty acid degradation_Homo sapiens_hsa00071	1.12766464
35	Asthma_Homo sapiens_hsa05310	1.12230921
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12048188
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11585233
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10059809
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09641551
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.08976009
41	Phototransduction_Homo sapiens_hsa04744	1.07746339
42	Sulfur relay system_Homo sapiens_hsa04122	1.03888544
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01876897
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.98383143
45	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98204435
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98042241
47	Glutathione metabolism_Homo sapiens_hsa00480	0.97782552
48	Platelet activation_Homo sapiens_hsa04611	0.97097488
49	Purine metabolism_Homo sapiens_hsa00230	0.95389081
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94771990
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86399815
52	Metabolic pathways_Homo sapiens_hsa01100	0.86097017
53	DNA replication_Homo sapiens_hsa03030	0.77115556
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76830049
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76335708
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75842789
57	Pancreatic secretion_Homo sapiens_hsa04972	0.72483310
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72232924
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71845684
60	Olfactory transduction_Homo sapiens_hsa04740	0.69391510
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65541543
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63112426
63	Serotonergic synapse_Homo sapiens_hsa04726	0.62963307
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62808301
65	Circadian entrainment_Homo sapiens_hsa04713	0.61395149
66	Base excision repair_Homo sapiens_hsa03410	0.60851082
67	Salivary secretion_Homo sapiens_hsa04970	0.59942242
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58485726
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55524706
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54909286
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54671043
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53589985
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53513724
74	African trypanosomiasis_Homo sapiens_hsa05143	0.53363306
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52877707
76	Allograft rejection_Homo sapiens_hsa05330	0.52830910
77	Taste transduction_Homo sapiens_hsa04742	0.52268729
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.51496571
79	Retinol metabolism_Homo sapiens_hsa00830	0.51175790
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.50617058
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.49343311
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.46974020
83	Morphine addiction_Homo sapiens_hsa05032	0.46531562
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46432520
85	Renin secretion_Homo sapiens_hsa04924	0.46413406
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46234366
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45613493
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44612996
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44424000
90	Long-term depression_Homo sapiens_hsa04730	0.41699647
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.41386963
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40470872
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39728909
94	RNA degradation_Homo sapiens_hsa03018	0.39261146
95	Spliceosome_Homo sapiens_hsa03040	0.37515536
96	RNA transport_Homo sapiens_hsa03013	0.32723449
97	One carbon pool by folate_Homo sapiens_hsa00670	0.31248543
98	Folate biosynthesis_Homo sapiens_hsa00790	0.30962371
99	Phagosome_Homo sapiens_hsa04145	0.30600899
100	GABAergic synapse_Homo sapiens_hsa04727	0.30196600

RPL23AP49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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