RPL23AP52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.13860216
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94768203
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.94635201
4ATP synthesis coupled proton transport (GO:0015986)4.94635201
5proteasome assembly (GO:0043248)4.68258303
6protein prenylation (GO:0018342)4.40129953
7prenylation (GO:0097354)4.40129953
8chaperone-mediated protein transport (GO:0072321)4.26479303
9preassembly of GPI anchor in ER membrane (GO:0016254)4.11020428
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07708257
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.05927679
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.05927679
13positive regulation of prostaglandin secretion (GO:0032308)3.71763007
14respiratory electron transport chain (GO:0022904)3.65866975
15electron transport chain (GO:0022900)3.64007400
16cell wall macromolecule metabolic process (GO:0044036)3.63411845
17protein neddylation (GO:0045116)3.54616844
18protein complex biogenesis (GO:0070271)3.48610656
19protein-cofactor linkage (GO:0018065)3.43424464
20peptidyl-histidine modification (GO:0018202)3.39742825
21ribosomal small subunit assembly (GO:0000028)3.39607585
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.38852637
23NADH dehydrogenase complex assembly (GO:0010257)3.38852637
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38852637
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25373214
26respiratory chain complex IV assembly (GO:0008535)3.23254654
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22678878
28mitochondrial respiratory chain complex assembly (GO:0033108)3.18756621
29positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.16765500
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16055110
31positive regulation of immune response to tumor cell (GO:0002839)3.09872438
32regulation of immune response to tumor cell (GO:0002837)3.09872438
33regulation of response to tumor cell (GO:0002834)3.09872438
34positive regulation of response to tumor cell (GO:0002836)3.09872438
35organ formation (GO:0048645)3.09317852
36positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08496587
37ATP biosynthetic process (GO:0006754)3.02986834
38platelet dense granule organization (GO:0060155)3.02551225
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00219714
40response to pheromone (GO:0019236)2.97671245
41neural tube formation (GO:0001841)2.96478749
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93065503
43axoneme assembly (GO:0035082)2.90639512
44regulation of memory T cell differentiation (GO:0043380)2.89719705
45regulation of germinal center formation (GO:0002634)2.88458687
46cytochrome complex assembly (GO:0017004)2.86149087
47regulation of immunoglobulin secretion (GO:0051023)2.84167852
48positive regulation of T cell cytokine production (GO:0002726)2.81581838
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81032742
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.80367457
51regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.79811305
52positive regulation of T cell mediated cytotoxicity (GO:0001916)2.79116472
53regulation of prostaglandin secretion (GO:0032306)2.78025540
54hydrogen ion transmembrane transport (GO:1902600)2.76265072
55water-soluble vitamin biosynthetic process (GO:0042364)2.76222493
56proton transport (GO:0015992)2.71545352
57dopamine transport (GO:0015872)2.71375039
58intracellular protein transmembrane import (GO:0044743)2.71146207
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70232148
60positive regulation of response to biotic stimulus (GO:0002833)2.70092222
61response to redox state (GO:0051775)2.68789354
62pseudouridine synthesis (GO:0001522)2.68456979
63L-fucose catabolic process (GO:0042355)2.66755895
64fucose catabolic process (GO:0019317)2.66755895
65L-fucose metabolic process (GO:0042354)2.66755895
66hydrogen transport (GO:0006818)2.66708032
67termination of RNA polymerase III transcription (GO:0006386)2.66030457
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.66030457
69regulation of T cell mediated cytotoxicity (GO:0001914)2.63866554
70positive regulation of protein homodimerization activity (GO:0090073)2.62249903
71GTP biosynthetic process (GO:0006183)2.61647955
72C-terminal protein lipidation (GO:0006501)2.60793606
73positive regulation of fatty acid transport (GO:2000193)2.60606717
74positive regulation of defense response to virus by host (GO:0002230)2.59532074
75gonadal mesoderm development (GO:0007506)2.58736951
76positive regulation of icosanoid secretion (GO:0032305)2.54473427
77detection of light stimulus involved in sensory perception (GO:0050962)2.54137973
78detection of light stimulus involved in visual perception (GO:0050908)2.54137973
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51891488
80isotype switching (GO:0045190)2.51891488
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51891488
82ribonucleoside triphosphate biosynthetic process (GO:0009201)2.50908867
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49241331
84inositol phosphate catabolic process (GO:0071545)2.47992303
85response to interferon-beta (GO:0035456)2.47120295
86tRNA processing (GO:0008033)2.47030597
87auditory receptor cell stereocilium organization (GO:0060088)2.45214669
88GPI anchor metabolic process (GO:0006505)2.44287736
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42046557
90nucleoside diphosphate phosphorylation (GO:0006165)2.41884475
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41567753
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41567753
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41567753
94positive regulation of T cell mediated immunity (GO:0002711)2.40495381
95protein polyglutamylation (GO:0018095)2.39730927
96somite rostral/caudal axis specification (GO:0032525)2.37414819
97rRNA modification (GO:0000154)2.37333374
98positive regulation of interleukin-12 production (GO:0032735)2.37298985
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.37125502
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.37125502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33619825
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.20587646
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94806810
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.83515477
5VDR_22108803_ChIP-Seq_LS180_Human2.76561359
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.62791678
7ZNF274_21170338_ChIP-Seq_K562_Hela2.52683055
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48996238
9ELK1_19687146_ChIP-ChIP_HELA_Human2.37682105
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37586098
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33718553
12EWS_26573619_Chip-Seq_HEK293_Human2.30098165
13GBX2_23144817_ChIP-Seq_PC3_Human2.22735973
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.17985879
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11884100
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08603119
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07228297
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06152682
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01713287
20VDR_23849224_ChIP-Seq_CD4+_Human2.00386863
21FUS_26573619_Chip-Seq_HEK293_Human1.89287422
22IGF1R_20145208_ChIP-Seq_DFB_Human1.85239681
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78924727
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77841225
25P300_19829295_ChIP-Seq_ESCs_Human1.75508542
26TAF15_26573619_Chip-Seq_HEK293_Human1.74141569
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74103331
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.72594286
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72557751
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71563961
31MYC_18940864_ChIP-ChIP_HL60_Human1.69350631
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.65458848
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60266280
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57333405
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.55848104
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.55848104
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49843381
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48772309
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48366545
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45279760
41NANOG_19829295_ChIP-Seq_ESCs_Human1.44835110
42SOX2_19829295_ChIP-Seq_ESCs_Human1.44835110
43ER_23166858_ChIP-Seq_MCF-7_Human1.44013834
44TP53_22573176_ChIP-Seq_HFKS_Human1.43279645
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42986645
46FOXP3_21729870_ChIP-Seq_TREG_Human1.42895059
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42350951
48AR_20517297_ChIP-Seq_VCAP_Human1.40637873
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.40498963
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.40257501
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39235395
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36923453
53TCF4_22108803_ChIP-Seq_LS180_Human1.35875666
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33899427
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.31456780
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31096805
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30758006
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30168827
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29947434
60CBP_20019798_ChIP-Seq_JUKART_Human1.29863353
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29863353
62GATA3_26560356_Chip-Seq_TH2_Human1.26734264
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26012866
64BCAT_22108803_ChIP-Seq_LS180_Human1.25228307
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24686822
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23802477
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23232969
68PHF8_20622853_ChIP-Seq_HELA_Human1.22881448
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21936873
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21046182
71IRF1_19129219_ChIP-ChIP_H3396_Human1.17416971
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17246235
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.15112404
74NCOR_22424771_ChIP-Seq_293T_Human1.14555235
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14379254
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.14057179
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.11810382
78RBPJ_21746931_ChIP-Seq_IB4_Human1.11350227
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11338044
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09978869
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.09617068
82ETV1_20927104_ChIP-Seq_GIST48_Human1.09449568
83ERG_20517297_ChIP-Seq_VCAP_Human1.07570619
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.07338753
85SMAD4_21799915_ChIP-Seq_A2780_Human1.06783869
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.06634815
87FOXH1_21741376_ChIP-Seq_EPCs_Human1.06377833
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05668723
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05326916
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05143430
91HNFA_21074721_ChIP-Seq_CACO-2_Human1.04999215
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04458721
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03681693
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03523464
95AR_25329375_ChIP-Seq_VCAP_Human1.02909388
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02905159
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02083212
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01716998
99RUNX2_22187159_ChIP-Seq_PCA_Human1.00857480
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.00393041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.09370694
2MP0002163_abnormal_gland_morphology3.81500466
3MP0003195_calcinosis3.79208240
4MP0005379_endocrine/exocrine_gland_phen2.98096365
5MP0002102_abnormal_ear_morphology2.83151338
6MP0000685_abnormal_immune_system2.55415688
7MP0008877_abnormal_DNA_methylation2.48658909
8MP0008875_abnormal_xenobiotic_pharmacok2.32138254
9MP0008872_abnormal_physiological_respon2.23025257
10MP0002876_abnormal_thyroid_physiology2.21297029
11MP0001835_abnormal_antigen_presentation2.18000970
12MP0005084_abnormal_gallbladder_morpholo2.17511738
13MP0003011_delayed_dark_adaptation2.10632519
14MP0000516_abnormal_urinary_system2.09228452
15MP0005367_renal/urinary_system_phenotyp2.09228452
16MP0006292_abnormal_olfactory_placode2.00465176
17MP0006054_spinal_hemorrhage1.71191467
18MP0002837_dystrophic_cardiac_calcinosis1.66586318
19MP0005075_abnormal_melanosome_morpholog1.66014069
20MP0001790_abnormal_immune_system1.65098546
21MP0005387_immune_system_phenotype1.65098546
22MP0003724_increased_susceptibility_to1.64212191
23MP0000569_abnormal_digit_pigmentation1.64121728
24MP0000372_irregular_coat_pigmentation1.63513390
25MP0005503_abnormal_tendon_morphology1.63118568
26MP0000427_abnormal_hair_cycle1.62395375
27MP0005646_abnormal_pituitary_gland1.62099293
28MP0005671_abnormal_response_to1.61001320
29MP0003786_premature_aging1.57153613
30MP0005551_abnormal_eye_electrophysiolog1.56560436
31MP0001764_abnormal_homeostasis1.50419366
32MP0005253_abnormal_eye_physiology1.47685674
33MP0001501_abnormal_sleep_pattern1.46381428
34MP0003806_abnormal_nucleotide_metabolis1.46126276
35MP0002938_white_spotting1.45292179
36MP0006082_CNS_inflammation1.44858507
37MP0004142_abnormal_muscle_tone1.43762127
38MP0002138_abnormal_hepatobiliary_system1.41170146
39MP0005167_abnormal_blood-brain_barrier1.40860573
40MP0003646_muscle_fatigue1.38624236
41MP0003787_abnormal_imprinting1.38542837
42MP0002148_abnormal_hypersensitivity_rea1.36460282
43MP0002234_abnormal_pharynx_morphology1.34934473
44MP0004381_abnormal_hair_follicle1.34592022
45MP0005645_abnormal_hypothalamus_physiol1.33841687
46MP0009785_altered_susceptibility_to1.29861137
47MP0003252_abnormal_bile_duct1.28023878
48MP0001348_abnormal_lacrimal_gland1.23835224
49MP0001919_abnormal_reproductive_system1.20581573
50MP0005410_abnormal_fertilization1.20444251
51MP0003183_abnormal_peptide_metabolism1.18946969
52MP0004145_abnormal_muscle_electrophysio1.17234599
53MP0002751_abnormal_autonomic_nervous1.15742930
54MP0001800_abnormal_humoral_immune1.13989336
55MP0001529_abnormal_vocalization1.10937455
56MP0006072_abnormal_retinal_apoptosis1.08932254
57MP0000383_abnormal_hair_follicle1.08385901
58MP0003718_maternal_effect1.06677884
59MP0005389_reproductive_system_phenotype1.05511604
60MP0009379_abnormal_foot_pigmentation1.02675964
61MP0003880_abnormal_central_pattern1.01408336
62MP0003763_abnormal_thymus_physiology1.01186106
63MP0002277_abnormal_respiratory_mucosa1.00731792
64MP0002254_reproductive_system_inflammat0.93240079
65MP0000631_abnormal_neuroendocrine_gland0.92424745
66MP0005085_abnormal_gallbladder_physiolo0.92260642
67MP0002736_abnormal_nociception_after0.89812114
68MP0001293_anophthalmia0.88949335
69MP0002928_abnormal_bile_duct0.86884939
70MP0009046_muscle_twitch0.85309793
71MP0001984_abnormal_olfaction0.84371628
72MP0000013_abnormal_adipose_tissue0.81791039
73MP0009250_abnormal_appendicular_skeleto0.80598195
74MP0004147_increased_porphyrin_level0.80147766
75MP0002723_abnormal_immune_serum0.80073274
76MP0008995_early_reproductive_senescence0.79899420
77MP0005220_abnormal_exocrine_pancreas0.79730542
78MP0002132_abnormal_respiratory_system0.79140481
79MP0002452_abnormal_antigen_presenting0.79051488
80MP0005000_abnormal_immune_tolerance0.79001730
81MP0009764_decreased_sensitivity_to0.78463866
82MP0005636_abnormal_mineral_homeostasis0.78337670
83MP0002127_abnormal_cardiovascular_syste0.78225776
84MP0009745_abnormal_behavioral_response0.77614102
85MP0000613_abnormal_salivary_gland0.74071226
86MP0008789_abnormal_olfactory_epithelium0.73929762
87MP0001819_abnormal_immune_cell0.73203595
88MP0002420_abnormal_adaptive_immunity0.73135081
89MP0000538_abnormal_urinary_bladder0.72153452
90MP0002693_abnormal_pancreas_physiology0.70390980
91MP0006036_abnormal_mitochondrial_physio0.69494474
92MP0004885_abnormal_endolymph0.68858481
93MP0000689_abnormal_spleen_morphology0.68817084
94MP0001968_abnormal_touch/_nociception0.68705754
95MP0005174_abnormal_tail_pigmentation0.68402336
96MP0002095_abnormal_skin_pigmentation0.66652116
97MP0004742_abnormal_vestibular_system0.64225804
98MP0001191_abnormal_skin_condition0.63540288
99MP0004215_abnormal_myocardial_fiber0.63307574
100MP0000049_abnormal_middle_ear0.62274355

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.76848212
2Acute necrotizing encephalopathy (HP:0006965)4.25655875
3Increased CSF lactate (HP:0002490)3.79354436
4Progressive macrocephaly (HP:0004481)3.77856170
5Mitochondrial inheritance (HP:0001427)3.74697663
6Abnormal mitochondria in muscle tissue (HP:0008316)3.52425270
7Acute encephalopathy (HP:0006846)3.51960726
8Increased IgM level (HP:0003496)3.50787684
9Pancreatic cysts (HP:0001737)3.20144548
10Cerebral edema (HP:0002181)3.19261897
11Attenuation of retinal blood vessels (HP:0007843)3.11735583
12Congenital stationary night blindness (HP:0007642)3.10271276
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03311031
14Abnormality of midbrain morphology (HP:0002418)3.02568717
15Molar tooth sign on MRI (HP:0002419)3.02568717
16Abnormality of the renal cortex (HP:0011035)3.00732913
17Methylmalonic aciduria (HP:0012120)2.88845780
18IgG deficiency (HP:0004315)2.87294949
19Optic disc pallor (HP:0000543)2.87289982
20Lipid accumulation in hepatocytes (HP:0006561)2.85630098
21Hepatocellular necrosis (HP:0001404)2.74377897
22Hypoproteinemia (HP:0003075)2.73056773
23Methylmalonic acidemia (HP:0002912)2.59386676
24Increased hepatocellular lipid droplets (HP:0006565)2.53165397
25Abnormal number of erythroid precursors (HP:0012131)2.51310906
26Metaphyseal dysplasia (HP:0100255)2.49377507
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42763085
28Abnormal rod and cone electroretinograms (HP:0008323)2.40207903
29Dicarboxylic aciduria (HP:0003215)2.36552797
30Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36552797
31Medial flaring of the eyebrow (HP:0010747)2.35456093
32Type II lissencephaly (HP:0007260)2.34133583
33Hepatic necrosis (HP:0002605)2.33453867
34Increased serum lactate (HP:0002151)2.33044049
35Lactic acidosis (HP:0003128)2.33038607
36Absent thumb (HP:0009777)2.27913163
37Congenital, generalized hypertrichosis (HP:0004540)2.27676153
38Abnormality of cells of the erythroid lineage (HP:0012130)2.21546186
39Abnormality of the renal medulla (HP:0100957)2.20099003
40Stomatitis (HP:0010280)2.19055775
41Abnormality of the renal collecting system (HP:0004742)2.18490418
42Large for gestational age (HP:0001520)2.18409203
43Renal cortical cysts (HP:0000803)2.16619735
44Hypomagnesemia (HP:0002917)2.14639932
45Abnormality of DNA repair (HP:0003254)2.14518058
46Nephronophthisis (HP:0000090)2.11725588
47Duplicated collecting system (HP:0000081)2.11509689
48Abnormality of B cell number (HP:0010975)2.10411236
49Retinal dysplasia (HP:0007973)2.10278792
50Respiratory failure (HP:0002878)2.09490276
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08491773
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.08299897
53Pancreatic fibrosis (HP:0100732)2.08119640
54Decreased central vision (HP:0007663)2.07481789
55Metabolic alkalosis (HP:0200114)2.02761393
56Abnormality of T cell physiology (HP:0011840)1.98264729
57Parakeratosis (HP:0001036)1.97155867
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96255667
59Hypokalemic alkalosis (HP:0001949)1.95505732
60Progressive microcephaly (HP:0000253)1.94680255
61Disproportionate short-trunk short stature (HP:0003521)1.93200221
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.92981021
63Abnormality of the phalanges of the 5th finger (HP:0004213)1.92870785
64Tetany (HP:0001281)1.91811977
65Leukodystrophy (HP:0002415)1.91623065
66True hermaphroditism (HP:0010459)1.91331617
67Volvulus (HP:0002580)1.89621591
68Thyroiditis (HP:0100646)1.83837533
69Aplasia/hypoplasia of the uterus (HP:0008684)1.82515481
70Microvesicular hepatic steatosis (HP:0001414)1.82130508
71Constricted visual fields (HP:0001133)1.81149055
72X-linked dominant inheritance (HP:0001423)1.80997673
73B lymphocytopenia (HP:0010976)1.80544462
74Stenosis of the external auditory canal (HP:0000402)1.79060587
75Lethargy (HP:0001254)1.78110434
76Fair hair (HP:0002286)1.77191177
77Bifid tongue (HP:0010297)1.76308964
78Neutropenia (HP:0001875)1.72417118
79Azoospermia (HP:0000027)1.72150437
80Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71858656
81Severe combined immunodeficiency (HP:0004430)1.71144097
82Sclerocornea (HP:0000647)1.70615623
83Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65730776
84Exercise intolerance (HP:0003546)1.65562435
85Renal Fanconi syndrome (HP:0001994)1.65550289
86Anomalous pulmonary venous return (HP:0010772)1.64856794
87Absent/shortened dynein arms (HP:0200106)1.63401702
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.63401702
89CNS demyelination (HP:0007305)1.63342230
90Polyuria (HP:0000103)1.63147074
91Tubular atrophy (HP:0000092)1.61823384
92Aplasia/Hypoplasia involving the musculature (HP:0001460)1.60942606
93Abnormal drinking behavior (HP:0030082)1.59877439
94Polydipsia (HP:0001959)1.59877439
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.59497442
96Short middle phalanx of the 5th finger (HP:0004220)1.59441219
97Pancytopenia (HP:0001876)1.58636996
98Abnormality of pyrimidine metabolism (HP:0004353)1.57843625
99Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.56894795
100Carpal bone hypoplasia (HP:0001498)1.56219077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.39348341
2FRK3.50967963
3NUAK12.98582215
4MAP3K122.88843790
5EIF2AK32.51593733
6TLK12.50244777
7TXK2.37048348
8ZAK2.31725528
9ADRBK22.29259208
10BCR2.21775412
11BMPR1B2.19071313
12LMTK22.07636492
13GRK12.04128830
14WNK31.70274688
15TNIK1.62666285
16BMPR21.57193234
17TIE11.56543030
18CDK191.53668164
19VRK21.49019281
20DAPK21.45521363
21TRIM281.42288617
22BCKDK1.41408816
23MAP4K11.39582805
24IKBKB1.39460397
25MAP3K41.36754805
26ACVR1B1.36263221
27PASK1.29545401
28MYLK1.27435424
29PTK2B1.27394623
30TSSK61.26626799
31INSRR1.24431846
32CASK1.22901718
33MST41.22178612
34CDK81.21646029
35VRK11.19003854
36WNK41.11348322
37CAMKK21.10440919
38TEC1.10224734
39DAPK11.08416161
40PLK41.06818851
41CDC71.06046138
42PINK11.01825389
43PAK30.98481664
44SRPK10.97085501
45OXSR10.96689690
46PLK20.96227516
47MKNK10.96119445
48MKNK20.96048839
49DAPK30.93473907
50EPHA40.93173727
51DYRK20.86145634
52PHKG20.85689918
53PHKG10.85689918
54TNK20.85493537
55ERBB30.83306092
56MAPKAPK50.83146481
57PLK30.80901667
58ADRBK10.78361220
59PDK20.77340608
60TAOK30.76314216
61PIK3CG0.72807210
62CSNK1G10.71747656
63NME10.69490447
64TGFBR10.66743458
65RPS6KA50.65906448
66EIF2AK20.63223612
67CSNK1G30.61200669
68PRKCE0.60774103
69FLT30.57499182
70TAF10.56167014
71SYK0.55469700
72NME20.55013393
73CSNK1A1L0.54818601
74GRK60.53887708
75EIF2AK10.53779435
76KIT0.53698521
77STK390.52222210
78PRKG20.49487177
79CSF1R0.48866558
80STK160.47574343
81AKT30.46621442
82PRKCQ0.45262127
83BUB10.43548987
84PRKCG0.42758097
85PIK3CA0.42495462
86ILK0.42227144
87ITK0.41695564
88LYN0.40376884
89CSNK1G20.40319743
90CAMK2A0.40255873
91AURKB0.38586514
92IGF1R0.38167789
93CSNK1A10.37993194
94PBK0.37776912
95BTK0.37024037
96MAPKAPK30.36713394
97PRKG10.36552285
98OBSCN0.35976926
99ABL10.33184845
100MELK0.32533771

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.77972380
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.04082187
3Protein export_Homo sapiens_hsa030603.00798420
4Parkinsons disease_Homo sapiens_hsa050122.98301187
5Asthma_Homo sapiens_hsa053102.96092204
6Proteasome_Homo sapiens_hsa030502.94037787
7Ribosome_Homo sapiens_hsa030102.63185805
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58770856
9Allograft rejection_Homo sapiens_hsa053302.45087800
10Homologous recombination_Homo sapiens_hsa034402.42217910
11Phototransduction_Homo sapiens_hsa047442.36707160
12Alzheimers disease_Homo sapiens_hsa050102.06180513
13Nitrogen metabolism_Homo sapiens_hsa009102.05258866
14Type I diabetes mellitus_Homo sapiens_hsa049402.01968822
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98901983
16Huntingtons disease_Homo sapiens_hsa050161.96601312
17Autoimmune thyroid disease_Homo sapiens_hsa053201.92726636
18RNA polymerase_Homo sapiens_hsa030201.89332503
19Caffeine metabolism_Homo sapiens_hsa002321.86927408
20Graft-versus-host disease_Homo sapiens_hsa053321.81488190
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66929952
22Sulfur metabolism_Homo sapiens_hsa009201.64763367
23Linoleic acid metabolism_Homo sapiens_hsa005911.64499060
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.53999491
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50464036
26RNA degradation_Homo sapiens_hsa030181.43000169
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42580936
28Cardiac muscle contraction_Homo sapiens_hsa042601.39379478
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38067405
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31839545
31Primary immunodeficiency_Homo sapiens_hsa053401.30926825
32Fanconi anemia pathway_Homo sapiens_hsa034601.30500071
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29930085
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28990279
35Basal transcription factors_Homo sapiens_hsa030221.25792195
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21399014
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18147409
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.15509397
39Rheumatoid arthritis_Homo sapiens_hsa053231.11989809
40Circadian rhythm_Homo sapiens_hsa047101.06326775
41Steroid biosynthesis_Homo sapiens_hsa001001.04503103
42Pyrimidine metabolism_Homo sapiens_hsa002401.02886206
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01275904
44Butanoate metabolism_Homo sapiens_hsa006500.96097386
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93610192
46Tryptophan metabolism_Homo sapiens_hsa003800.91667847
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.91103220
48Propanoate metabolism_Homo sapiens_hsa006400.90852837
49Antigen processing and presentation_Homo sapiens_hsa046120.89469473
50Purine metabolism_Homo sapiens_hsa002300.88476458
51Nucleotide excision repair_Homo sapiens_hsa034200.87814790
52Peroxisome_Homo sapiens_hsa041460.87617717
53Chemical carcinogenesis_Homo sapiens_hsa052040.86430842
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84924997
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84102861
56Ether lipid metabolism_Homo sapiens_hsa005650.82573304
57African trypanosomiasis_Homo sapiens_hsa051430.78944307
58Collecting duct acid secretion_Homo sapiens_hsa049660.77984648
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75370070
60Retinol metabolism_Homo sapiens_hsa008300.75085386
61Systemic lupus erythematosus_Homo sapiens_hsa053220.74731332
62Metabolic pathways_Homo sapiens_hsa011000.66568940
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.65631929
64Arachidonic acid metabolism_Homo sapiens_hsa005900.60996442
65Mismatch repair_Homo sapiens_hsa034300.60610177
66Hematopoietic cell lineage_Homo sapiens_hsa046400.59548381
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.58058456
68Olfactory transduction_Homo sapiens_hsa047400.56852195
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55010452
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54329600
71RNA transport_Homo sapiens_hsa030130.53857526
72Non-homologous end-joining_Homo sapiens_hsa034500.51842539
73Taste transduction_Homo sapiens_hsa047420.49683858
74One carbon pool by folate_Homo sapiens_hsa006700.46121667
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42975453
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42655199
77Herpes simplex infection_Homo sapiens_hsa051680.42610479
78Selenocompound metabolism_Homo sapiens_hsa004500.42386854
79Nicotine addiction_Homo sapiens_hsa050330.40775401
80Fat digestion and absorption_Homo sapiens_hsa049750.40500338
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39409792
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38848312
83ABC transporters_Homo sapiens_hsa020100.38631163
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38560171
85Morphine addiction_Homo sapiens_hsa050320.37495272
86Legionellosis_Homo sapiens_hsa051340.36087567
87Viral myocarditis_Homo sapiens_hsa054160.35177468
88Spliceosome_Homo sapiens_hsa030400.34338224
89Glutathione metabolism_Homo sapiens_hsa004800.33603732
90Measles_Homo sapiens_hsa051620.32274381
91Regulation of autophagy_Homo sapiens_hsa041400.32161085
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.30784567
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30106401
94Base excision repair_Homo sapiens_hsa034100.28557500
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28146007
96Staphylococcus aureus infection_Homo sapiens_hsa051500.26663349
97Vitamin B6 metabolism_Homo sapiens_hsa007500.26536303
98Serotonergic synapse_Homo sapiens_hsa047260.23169912
99Tyrosine metabolism_Homo sapiens_hsa003500.22959150
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21709454

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