RPL23AP55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.31168298
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.97043899
3cytidine metabolic process (GO:0046087)5.87916724
4cytidine catabolic process (GO:0006216)5.87916724
5cytidine deamination (GO:0009972)5.87916724
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.06286966
7ATP synthesis coupled proton transport (GO:0015986)4.79024218
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.79024218
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55133580
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23770950
11chaperone-mediated protein transport (GO:0072321)4.17171694
12ribosomal small subunit assembly (GO:0000028)4.10427059
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.89302923
14positive regulation of T cell mediated cytotoxicity (GO:0001916)3.88226737
15positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.84987887
16regulation of regulatory T cell differentiation (GO:0045589)3.68258213
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.67570643
18actin nucleation (GO:0045010)3.67446836
19activated T cell proliferation (GO:0050798)3.65075475
20positive regulation of natural killer cell mediated immunity (GO:0002717)3.64570728
21cellular response to interleukin-15 (GO:0071350)3.63446337
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.61207403
23interferon-gamma production (GO:0032609)3.59669565
24regulation of T cell mediated cytotoxicity (GO:0001914)3.52433033
25regulation of leukocyte mediated cytotoxicity (GO:0001910)3.51379014
26positive T cell selection (GO:0043368)3.50938795
27negative T cell selection (GO:0043383)3.50694371
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49931642
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45308627
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45308627
31regulation of T cell receptor signaling pathway (GO:0050856)3.40568474
32respiratory electron transport chain (GO:0022904)3.38450737
33positive regulation of cell killing (GO:0031343)3.38039842
34electron transport chain (GO:0022900)3.37414443
35mast cell activation (GO:0045576)3.36185116
36positive thymic T cell selection (GO:0045059)3.30916881
37viral transcription (GO:0019083)3.27493621
38regulation of interleukin-8 secretion (GO:2000482)3.24224233
39regulation of natural killer cell mediated immunity (GO:0002715)3.19669306
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.19669306
41sequestering of actin monomers (GO:0042989)3.19116759
42regulation of cell killing (GO:0031341)3.17390573
43translational termination (GO:0006415)3.14686925
44negative regulation of T cell apoptotic process (GO:0070233)3.14553931
45T cell receptor signaling pathway (GO:0050852)3.13825732
46regulation of chronic inflammatory response (GO:0002676)3.12789807
47platelet dense granule organization (GO:0060155)3.11870857
48cytolysis (GO:0019835)3.11725454
49regulation of B cell receptor signaling pathway (GO:0050855)3.10413152
50GDP-mannose metabolic process (GO:0019673)3.09209494
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.08623932
52positive regulation of defense response to virus by host (GO:0002230)3.07548751
53T cell migration (GO:0072678)3.02164700
54positive regulation of interleukin-8 secretion (GO:2000484)3.00732160
55translational elongation (GO:0006414)2.97779901
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96362426
57positive regulation of gamma-delta T cell activation (GO:0046645)2.94970327
58response to pheromone (GO:0019236)2.94727999
59positive regulation of T cell mediated immunity (GO:0002711)2.93795895
60positive regulation of tolerance induction (GO:0002645)2.93421279
61protein targeting to ER (GO:0045047)2.89003115
62cellular defense response (GO:0006968)2.88952352
63cotranslational protein targeting to membrane (GO:0006613)2.88695645
64regulation of gamma-delta T cell differentiation (GO:0045586)2.83696791
65positive regulation of calcium-mediated signaling (GO:0050850)2.83529113
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82220691
67regulation of T cell tolerance induction (GO:0002664)2.81039735
68protein neddylation (GO:0045116)2.80260007
69regulation of activation of Janus kinase activity (GO:0010533)2.79923510
70mast cell degranulation (GO:0043303)2.78439453
71mast cell activation involved in immune response (GO:0002279)2.78439453
72ATP biosynthetic process (GO:0006754)2.77797305
73establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75827650
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75068682
75protein localization to endoplasmic reticulum (GO:0070972)2.74658841
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73982452
77hydrogen ion transmembrane transport (GO:1902600)2.73233277
78negative regulation of mast cell activation (GO:0033004)2.73184367
79antigen receptor-mediated signaling pathway (GO:0050851)2.71131867
80T cell costimulation (GO:0031295)2.70833435
81lymphocyte costimulation (GO:0031294)2.69063420
82negative thymic T cell selection (GO:0045060)2.68445841
83regulation of cellular amino acid metabolic process (GO:0006521)2.68349070
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65387705
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63325284
86response to interleukin-15 (GO:0070672)2.63232015
87positive regulation of uterine smooth muscle contraction (GO:0070474)2.61813844
88proton transport (GO:0015992)2.60954935
89negative regulation of calcium ion transport into cytosol (GO:0010523)2.60509064
90pyrimidine nucleoside catabolic process (GO:0046135)2.58828402
91positive regulation of lymphocyte mediated immunity (GO:0002708)2.58415562
92natural killer cell activation (GO:0030101)2.58075539
93regulation of B cell differentiation (GO:0045577)2.56869779
94hydrogen transport (GO:0006818)2.55635574
95antigen processing and presentation via MHC class Ib (GO:0002475)2.54866681
96regulation of alpha-beta T cell proliferation (GO:0046640)2.54785630
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53835740
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53835740
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53835740
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52358104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.76396402
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92629701
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.40566836
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28400400
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.15520881
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04615468
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.04223702
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99354205
9VDR_22108803_ChIP-Seq_LS180_Human2.97795900
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.86992484
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.57191150
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45519774
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43220962
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.31635264
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.25959549
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25327534
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10329553
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08831618
19RUNX_20019798_ChIP-Seq_JUKART_Human2.08172206
20VDR_23849224_ChIP-Seq_CD4+_Human2.07991063
21MYB_26560356_Chip-Seq_TH2_Human2.03283768
22ZNF274_21170338_ChIP-Seq_K562_Hela2.01244023
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.93154153
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84801725
25GATA3_26560356_Chip-Seq_TH2_Human1.82662871
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71925113
27IGF1R_20145208_ChIP-Seq_DFB_Human1.68139566
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63790503
29EZH2_22144423_ChIP-Seq_EOC_Human1.63146857
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61282402
31ELK1_19687146_ChIP-ChIP_HELA_Human1.60598166
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.57425317
33GATA3_27048872_Chip-Seq_THYMUS_Human1.54856221
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51700948
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51218163
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45361090
37FOXP3_21729870_ChIP-Seq_TREG_Human1.44037506
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42450203
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.42406633
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40617204
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40617204
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40407941
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39720975
44TP53_22573176_ChIP-Seq_HFKS_Human1.39414170
45AR_20517297_ChIP-Seq_VCAP_Human1.39167938
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35960731
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33082854
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32888713
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29185219
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28406318
51MYB_26560356_Chip-Seq_TH1_Human1.26791527
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25953096
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.25244843
54GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25088388
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.24152928
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20798223
57NANOG_20526341_ChIP-Seq_ESCs_Human1.17948864
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17246945
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16735199
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16111167
61NANOG_19829295_ChIP-Seq_ESCs_Human1.15990798
62SOX2_19829295_ChIP-Seq_ESCs_Human1.15990798
63ER_23166858_ChIP-Seq_MCF-7_Human1.15964808
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14737056
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.14238684
66NCOR_22424771_ChIP-Seq_293T_Human1.13724805
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12391311
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11963649
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11482876
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11163146
71TAF2_19829295_ChIP-Seq_ESCs_Human1.10688597
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10201313
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.08938906
74FUS_26573619_Chip-Seq_HEK293_Human1.08583896
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08228897
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07819420
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05961221
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.05593135
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.02520167
80MYC_19829295_ChIP-Seq_ESCs_Human1.02295610
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.01655969
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01349893
83P300_19829295_ChIP-Seq_ESCs_Human1.01059544
84HTT_18923047_ChIP-ChIP_STHdh_Human1.00632281
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00336763
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99650979
87BCAT_22108803_ChIP-Seq_LS180_Human0.99297108
88MYC_18940864_ChIP-ChIP_HL60_Human0.98703578
89RBPJ_21746931_ChIP-Seq_IB4_Human0.97811554
90SPI1_23547873_ChIP-Seq_NB4_Human0.96609471
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96141959
92GATA3_26560356_Chip-Seq_TH1_Human0.95164179
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95022894
94ERG_20517297_ChIP-Seq_VCAP_Human0.94109378
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93470485
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93153150
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92800131
98TAF15_26573619_Chip-Seq_HEK293_Human0.92715847
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89980134
100IRF1_19129219_ChIP-ChIP_H3396_Human0.89139612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.10676781
2MP0001835_abnormal_antigen_presentation3.49369994
3MP0009785_altered_susceptibility_to2.97066511
4MP0006072_abnormal_retinal_apoptosis2.81275838
5MP0002638_abnormal_pupillary_reflex2.59875532
6MP0005000_abnormal_immune_tolerance2.49443022
7MP0009379_abnormal_foot_pigmentation2.48388996
8MP0002148_abnormal_hypersensitivity_rea2.39875422
9MP0005387_immune_system_phenotype2.38524279
10MP0001790_abnormal_immune_system2.38524279
11MP0009333_abnormal_splenocyte_physiolog2.36330891
12MP0003763_abnormal_thymus_physiology2.34196421
13MP0001800_abnormal_humoral_immune2.30255101
14MP0000685_abnormal_immune_system2.24870629
15MP0002723_abnormal_immune_serum2.10458130
16MP0002166_altered_tumor_susceptibility2.01399113
17MP0002420_abnormal_adaptive_immunity1.98197993
18MP0002102_abnormal_ear_morphology1.96193256
19MP0001819_abnormal_immune_cell1.95417910
20MP0003646_muscle_fatigue1.93855979
21MP0008872_abnormal_physiological_respon1.93477053
22MP0005025_abnormal_response_to1.89426580
23MP0002452_abnormal_antigen_presenting1.82377632
24MP0003436_decreased_susceptibility_to1.81600473
25MP0003724_increased_susceptibility_to1.80898094
26MP0006082_CNS_inflammation1.80845268
27MP0001873_stomach_inflammation1.77650489
28MP0004885_abnormal_endolymph1.72588545
29MP0000372_irregular_coat_pigmentation1.66544438
30MP0009764_decreased_sensitivity_to1.66176852
31MP0003195_calcinosis1.63249553
32MP0005645_abnormal_hypothalamus_physiol1.62194024
33MP0001919_abnormal_reproductive_system1.62114953
34MP0003866_abnormal_defecation1.54733222
35MP0002006_tumorigenesis1.52659990
36MP0008875_abnormal_xenobiotic_pharmacok1.50145131
37MP0010155_abnormal_intestine_physiology1.47933148
38MP0002163_abnormal_gland_morphology1.47137745
39MP0002398_abnormal_bone_marrow1.46845703
40MP0005389_reproductive_system_phenotype1.46163170
41MP0000716_abnormal_immune_system1.45870431
42MP0004147_increased_porphyrin_level1.40428671
43MP0005075_abnormal_melanosome_morpholog1.40119070
44MP0005253_abnormal_eye_physiology1.39786546
45MP0001905_abnormal_dopamine_level1.37807581
46MP0005551_abnormal_eye_electrophysiolog1.36406033
47MP0002837_dystrophic_cardiac_calcinosis1.35494073
48MP0005646_abnormal_pituitary_gland1.35084276
49MP0001845_abnormal_inflammatory_respons1.32990958
50MP0003878_abnormal_ear_physiology1.31851779
51MP0005377_hearing/vestibular/ear_phenot1.31851779
52MP0002933_joint_inflammation1.28995357
53MP0002405_respiratory_system_inflammati1.26188887
54MP0001968_abnormal_touch/_nociception1.26080049
55MP0001986_abnormal_taste_sensitivity1.22359469
56MP0002419_abnormal_innate_immunity1.21657398
57MP0000689_abnormal_spleen_morphology1.19868112
58MP0004145_abnormal_muscle_electrophysio1.18808156
59MP0002722_abnormal_immune_system1.16786940
60MP0002736_abnormal_nociception_after1.16142394
61MP0005670_abnormal_white_adipose1.14436966
62MP0001984_abnormal_olfaction1.12492161
63MP0001501_abnormal_sleep_pattern1.12492098
64MP0002876_abnormal_thyroid_physiology1.10160349
65MP0008995_early_reproductive_senescence1.07248893
66MP0002429_abnormal_blood_cell1.05671925
67MP0005410_abnormal_fertilization1.05153125
68MP0000703_abnormal_thymus_morphology1.04919955
69MP0002234_abnormal_pharynx_morphology1.04750848
70MP0005174_abnormal_tail_pigmentation1.01174652
71MP0008877_abnormal_DNA_methylation0.99221880
72MP0008469_abnormal_protein_level0.96469261
73MP0002277_abnormal_respiratory_mucosa0.95306541
74MP0001533_abnormal_skeleton_physiology0.95082049
75MP0005636_abnormal_mineral_homeostasis0.94909110
76MP0003806_abnormal_nucleotide_metabolis0.94687337
77MP0004947_skin_inflammation0.89709815
78MP0005464_abnormal_platelet_physiology0.89153571
79MP0004142_abnormal_muscle_tone0.88161020
80MP0002095_abnormal_skin_pigmentation0.87846802
81MP0002160_abnormal_reproductive_system0.87559837
82MP0006036_abnormal_mitochondrial_physio0.87029329
83MP0005379_endocrine/exocrine_gland_phen0.84205515
84MP0001765_abnormal_ion_homeostasis0.81981256
85MP0009763_increased_sensitivity_to0.81510973
86MP0005503_abnormal_tendon_morphology0.77414803
87MP0002693_abnormal_pancreas_physiology0.76132545
88MP0009745_abnormal_behavioral_response0.75786227
89MP0001542_abnormal_bone_strength0.75740552
90MP0008961_abnormal_basal_metabolism0.75150293
91MP0004043_abnormal_pH_regulation0.74438498
92MP0003786_premature_aging0.73933531
93MP0003011_delayed_dark_adaptation0.73377639
94MP0003137_abnormal_impulse_conducting0.72558757
95MP0003638_abnormal_response/metabolism_0.72232676
96MP0009697_abnormal_copulation0.68604960
97MP0009765_abnormal_xenobiotic_induced0.63693176
98MP0001529_abnormal_vocalization0.63087566
99MP0001963_abnormal_hearing_physiology0.61708274
100MP0001485_abnormal_pinna_reflex0.61630706

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.54082731
2Hypoproteinemia (HP:0003075)4.17836693
3Congenital stationary night blindness (HP:0007642)3.99925902
4Elevated erythrocyte sedimentation rate (HP:0003565)3.70687023
5Abnormality of T cell number (HP:0011839)3.67816897
6Mitochondrial inheritance (HP:0001427)3.63705212
7T lymphocytopenia (HP:0005403)3.61027870
8Aplastic anemia (HP:0001915)3.46296098
9Abnormality of B cell number (HP:0010975)3.41223769
103-Methylglutaconic aciduria (HP:0003535)3.40807504
11Stomatitis (HP:0010280)3.40490871
12Hepatocellular necrosis (HP:0001404)3.32461764
13Increased CSF lactate (HP:0002490)3.20137503
14Acute necrotizing encephalopathy (HP:0006965)3.19521801
15Increased hepatocellular lipid droplets (HP:0006565)3.04776604
16Severe combined immunodeficiency (HP:0004430)3.02642124
17Increased IgM level (HP:0003496)3.01321888
18Abnormality of eosinophils (HP:0001879)2.97232405
19Autoimmune hemolytic anemia (HP:0001890)2.95588763
20Congenital, generalized hypertrichosis (HP:0004540)2.93931913
21Abnormal mitochondria in muscle tissue (HP:0008316)2.89923006
22Lipid accumulation in hepatocytes (HP:0006561)2.87495735
23Abnormality of T cells (HP:0002843)2.84230817
24Methylmalonic acidemia (HP:0002912)2.84156074
25B lymphocytopenia (HP:0010976)2.83161330
26Hepatic necrosis (HP:0002605)2.81632565
27Thyroiditis (HP:0100646)2.70808623
28Progressive macrocephaly (HP:0004481)2.68733320
29Global brain atrophy (HP:0002283)2.67459969
30Renal Fanconi syndrome (HP:0001994)2.66884205
31Acute encephalopathy (HP:0006846)2.62404998
32Stenosis of the external auditory canal (HP:0000402)2.61892931
33Eosinophilia (HP:0001880)2.59350907
34Increased intramyocellular lipid droplets (HP:0012240)2.57453332
35Exertional dyspnea (HP:0002875)2.57177854
36Pancreatic cysts (HP:0001737)2.54757282
37Chronic diarrhea (HP:0002028)2.54561738
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54560725
39Abnormality of the prostate (HP:0008775)2.46955842
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43774697
41Attenuation of retinal blood vessels (HP:0007843)2.34973829
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34859412
43Abnormality of the renal cortex (HP:0011035)2.31616960
44Combined immunodeficiency (HP:0005387)2.27999411
45Abnormal rod and cone electroretinograms (HP:0008323)2.26961963
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25475076
47Dyskinesia (HP:0100660)2.23240901
48Increased muscle lipid content (HP:0009058)2.22110598
49Methylmalonic aciduria (HP:0012120)2.18454396
50Increased serum lactate (HP:0002151)2.18258731
51Stomach cancer (HP:0012126)2.16404598
52Leukocytosis (HP:0001974)2.15508987
53Molar tooth sign on MRI (HP:0002419)2.11409333
54Abnormality of midbrain morphology (HP:0002418)2.11409333
55Recurrent bronchitis (HP:0002837)2.10148532
56Optic disc pallor (HP:0000543)2.07933645
57Encephalitis (HP:0002383)2.05297478
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04929468
59Abnormality of cells of the erythroid lineage (HP:0012130)2.04812090
60Abnormality of T cell physiology (HP:0011840)2.04521008
61Papilledema (HP:0001085)2.03108466
62Pancytopenia (HP:0001876)2.02678255
63Macrocytic anemia (HP:0001972)2.02481381
64Myositis (HP:0100614)2.00751964
65IgM deficiency (HP:0002850)2.00636847
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99575961
67Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99575961
68Abnormality of the pons (HP:0007361)1.98574498
69Decreased central vision (HP:0007663)1.97130940
70Pulmonary infiltrates (HP:0002113)1.96464911
71Abolished electroretinogram (ERG) (HP:0000550)1.96282740
72True hermaphroditism (HP:0010459)1.96223621
73Cerebral edema (HP:0002181)1.95934159
74Abnormal albumin level (HP:0012116)1.95209263
75Hypoalbuminemia (HP:0003073)1.95209263
76Renal cortical cysts (HP:0000803)1.94444262
77Pancreatic fibrosis (HP:0100732)1.93631290
78Pustule (HP:0200039)1.93386445
79Lactic acidosis (HP:0003128)1.92833178
80Aplasia/hypoplasia of the uterus (HP:0008684)1.92423535
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92000869
82Abnormality of alanine metabolism (HP:0010916)1.92000869
83Hyperalaninemia (HP:0003348)1.92000869
84Oral leukoplakia (HP:0002745)1.91742701
85Autoimmune thrombocytopenia (HP:0001973)1.91513368
86Bronchitis (HP:0012387)1.86864377
87Panhypogammaglobulinemia (HP:0003139)1.86615968
88Type 2 muscle fiber atrophy (HP:0003554)1.86319736
89Neurodegeneration (HP:0002180)1.85423319
90Constricted visual fields (HP:0001133)1.84663567
91Hypoplasia of the pons (HP:0012110)1.81128301
92Abnormal number of erythroid precursors (HP:0012131)1.80802704
93Abnormal drinking behavior (HP:0030082)1.78218898
94Polydipsia (HP:0001959)1.78218898
95Retrobulbar optic neuritis (HP:0100654)1.76580273
96Optic neuritis (HP:0100653)1.76580273
97Abnormality of the vitamin B12 metabolism (HP:0004341)1.76345201
98CNS demyelination (HP:0007305)1.75916066
99Large eyes (HP:0001090)1.74899538
100Granulocytopenia (HP:0001913)1.74811624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.91409303
2TLK13.99953548
3KDR3.75829429
4ZAK3.24284932
5TAOK32.90241423
6TESK22.61577767
7MAP4K22.40798499
8BMPR22.38722376
9MAP4K12.29484303
10MAP3K122.26535667
11ADRBK22.19617689
12PASK2.18509714
13TEC2.17603560
14ITK2.07221570
15BCKDK2.05902491
16GRK61.94670598
17FRK1.83828050
18GRK11.83030282
19CDK191.81000624
20MAP2K61.72314578
21MST41.69712392
22MUSK1.62822715
23VRK21.50182401
24BTK1.45715911
25SYK1.45673478
26INSRR1.38381632
27WNK41.35223681
28FES1.35033762
29NUAK11.34198418
30VRK11.30806646
31MYLK1.30051579
32IKBKB1.26070005
33OXSR11.23999698
34LCK1.17836183
35GRK71.14511256
36ERBB31.14075165
37LIMK11.11974632
38PINK11.08135361
39KIT1.04881026
40SCYL20.96339177
41NME10.95904426
42PIK3CG0.92917018
43STK390.92067568
44PRKCQ0.87749153
45TESK10.86663265
46ZAP700.84332799
47TNK20.83970152
48TRPM70.81181388
49IKBKE0.80802936
50LYN0.80611505
51SRPK10.74874183
52CAMKK20.74389979
53PIM10.71886452
54CAMKK10.71862418
55BUB10.71490728
56CSF1R0.71282645
57OBSCN0.68530517
58IGF1R0.63635758
59RIPK40.62926348
60DAPK20.62688530
61TIE10.62236165
62BMPR1B0.60641050
63RPS6KA50.59703988
64EIF2AK30.59473197
65ROCK10.57752412
66DAPK10.57691218
67CSK0.55756272
68TBK10.54520721
69PHKG10.53815617
70PHKG20.53815617
71TAOK20.53033735
72WNK30.52570367
73MAP2K20.51108074
74PIK3CA0.50124830
75ADRBK10.49502849
76HCK0.48719469
77PKN10.48109059
78PRKCA0.46636067
79DAPK30.45606088
80PTK2B0.44869751
81CDK80.44746240
82FLT30.43331996
83ABL10.41862351
84PDK20.41290915
85GRK50.40544194
86JAK30.39335781
87EIF2AK20.38650117
88PRKACA0.37965865
89MAP3K110.37173959
90PRKCD0.35740426
91MAPKAPK30.34795703
92CSNK2A10.33738695
93MATK0.33051545
94FYN0.31183471
95INSR0.26310967
96PRKCE0.25869380
97PIM20.25001556
98CAMK2A0.24861035
99PRKG10.24774178
100CSNK2A20.23979249

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.91418607
2Graft-versus-host disease_Homo sapiens_hsa053323.60621348
3Proteasome_Homo sapiens_hsa030503.52369188
4Oxidative phosphorylation_Homo sapiens_hsa001903.30546942
5Ribosome_Homo sapiens_hsa030103.25946255
6Allograft rejection_Homo sapiens_hsa053303.13603338
7Autoimmune thyroid disease_Homo sapiens_hsa053203.11298761
8Asthma_Homo sapiens_hsa053102.73151431
9Parkinsons disease_Homo sapiens_hsa050122.63805233
10Antigen processing and presentation_Homo sapiens_hsa046122.60482733
11Type I diabetes mellitus_Homo sapiens_hsa049402.57368373
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.49906728
13Hematopoietic cell lineage_Homo sapiens_hsa046401.87087429
14RNA polymerase_Homo sapiens_hsa030201.81636007
15Alzheimers disease_Homo sapiens_hsa050101.80166311
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77968771
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72563916
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72556620
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72431687
20Protein export_Homo sapiens_hsa030601.57939328
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57592260
22T cell receptor signaling pathway_Homo sapiens_hsa046601.53870692
23Huntingtons disease_Homo sapiens_hsa050161.52510474
24Cardiac muscle contraction_Homo sapiens_hsa042601.50160141
25Nitrogen metabolism_Homo sapiens_hsa009101.47188813
26Phototransduction_Homo sapiens_hsa047441.46157748
27Rheumatoid arthritis_Homo sapiens_hsa053231.44769749
28Caffeine metabolism_Homo sapiens_hsa002321.43630573
29Linoleic acid metabolism_Homo sapiens_hsa005911.39917884
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23497235
31Viral myocarditis_Homo sapiens_hsa054161.23309540
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.19790465
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14360520
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14006359
35Homologous recombination_Homo sapiens_hsa034401.13190426
36RNA degradation_Homo sapiens_hsa030181.09294884
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01723816
38Staphylococcus aureus infection_Homo sapiens_hsa051500.94104652
39Malaria_Homo sapiens_hsa051440.93702743
40Chemical carcinogenesis_Homo sapiens_hsa052040.92247934
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90906610
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87801731
43One carbon pool by folate_Homo sapiens_hsa006700.87088886
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86451844
45Systemic lupus erythematosus_Homo sapiens_hsa053220.82572543
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81099246
47Tryptophan metabolism_Homo sapiens_hsa003800.79677719
48Leishmaniasis_Homo sapiens_hsa051400.79570375
49Olfactory transduction_Homo sapiens_hsa047400.78995163
50Sulfur metabolism_Homo sapiens_hsa009200.76193315
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.74505788
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73594305
53Peroxisome_Homo sapiens_hsa041460.70365033
54Regulation of autophagy_Homo sapiens_hsa041400.69336812
55Arachidonic acid metabolism_Homo sapiens_hsa005900.67969972
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.65649511
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63740089
58Purine metabolism_Homo sapiens_hsa002300.63359068
59Basal transcription factors_Homo sapiens_hsa030220.61872737
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61054626
61Retinol metabolism_Homo sapiens_hsa008300.60751103
62Measles_Homo sapiens_hsa051620.59744107
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59587322
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57871060
65Collecting duct acid secretion_Homo sapiens_hsa049660.55500897
66Taste transduction_Homo sapiens_hsa047420.55058758
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.53429875
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.53031209
69Pyrimidine metabolism_Homo sapiens_hsa002400.52486321
70Fanconi anemia pathway_Homo sapiens_hsa034600.45777682
71Ether lipid metabolism_Homo sapiens_hsa005650.44579642
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44146070
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43425837
74Herpes simplex infection_Homo sapiens_hsa051680.43350502
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43158765
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41961655
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41055424
78African trypanosomiasis_Homo sapiens_hsa051430.40313905
79Butanoate metabolism_Homo sapiens_hsa006500.40008618
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38813472
81ABC transporters_Homo sapiens_hsa020100.38268954
82Spliceosome_Homo sapiens_hsa030400.37466709
83Shigellosis_Homo sapiens_hsa051310.37390101
84Morphine addiction_Homo sapiens_hsa050320.36420213
85Metabolic pathways_Homo sapiens_hsa011000.36130642
86Nicotine addiction_Homo sapiens_hsa050330.36098202
87Pertussis_Homo sapiens_hsa051330.35668050
88Base excision repair_Homo sapiens_hsa034100.34708163
89Nucleotide excision repair_Homo sapiens_hsa034200.34563803
90Propanoate metabolism_Homo sapiens_hsa006400.33269367
91Salmonella infection_Homo sapiens_hsa051320.29543903
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28560961
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26780504
94Mismatch repair_Homo sapiens_hsa034300.26606660
95Fat digestion and absorption_Homo sapiens_hsa049750.26153966
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24702343
97DNA replication_Homo sapiens_hsa030300.24665286
98Salivary secretion_Homo sapiens_hsa049700.24525142
99Vitamin digestion and absorption_Homo sapiens_hsa049770.19024932
100Epstein-Barr virus infection_Homo sapiens_hsa051690.18289878

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