RPL23AP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.34377192
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.71651622
3cytidine deamination (GO:0009972)5.67494928
4cytidine metabolic process (GO:0046087)5.67494928
5cytidine catabolic process (GO:0006216)5.67494928
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.42174735
7ATP synthesis coupled proton transport (GO:0015986)5.22750212
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22750212
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.93165605
10ribosomal small subunit assembly (GO:0000028)4.73437638
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58145050
12regulation of B cell receptor signaling pathway (GO:0050855)4.38557172
13respiratory electron transport chain (GO:0022904)4.31542360
14electron transport chain (GO:0022900)4.27123929
15viral transcription (GO:0019083)4.15661929
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08639536
17translational termination (GO:0006415)3.96332928
18regulation of activation of Janus kinase activity (GO:0010533)3.91577833
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84484702
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68159237
21protein targeting to ER (GO:0045047)3.63173416
22translational elongation (GO:0006414)3.61692611
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.60824829
24cotranslational protein targeting to membrane (GO:0006613)3.60429884
25positive thymic T cell selection (GO:0045059)3.60189522
26maturation of SSU-rRNA (GO:0030490)3.51999047
27positive T cell selection (GO:0043368)3.50255378
28regulation of regulatory T cell differentiation (GO:0045589)3.49510797
29actin nucleation (GO:0045010)3.46789929
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46049998
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.45017109
32protein localization to endoplasmic reticulum (GO:0070972)3.44690578
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.37427612
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.36189155
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.26977107
36positive regulation of natural killer cell mediated immunity (GO:0002717)3.26893268
37negative T cell selection (GO:0043383)3.25974571
38negative regulation of T cell apoptotic process (GO:0070233)3.25359829
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.22981831
40ribosomal small subunit biogenesis (GO:0042274)3.22934820
41protein neddylation (GO:0045116)3.22645459
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22042366
43regulation of T cell receptor signaling pathway (GO:0050856)3.18656879
44regulation of leukocyte mediated cytotoxicity (GO:0001910)3.17580353
45protein complex biogenesis (GO:0070271)3.17137553
46T cell migration (GO:0072678)3.16282762
47regulation of chronic inflammatory response (GO:0002676)3.13568413
48cellular response to interleukin-15 (GO:0071350)3.11425537
49regulation of T cell mediated cytotoxicity (GO:0001914)3.08786774
50T cell receptor signaling pathway (GO:0050852)3.06542199
51positive regulation of calcium-mediated signaling (GO:0050850)3.05061824
52positive regulation of cell killing (GO:0031343)3.03755688
53T cell costimulation (GO:0031295)3.02979535
54lymphocyte costimulation (GO:0031294)3.02697060
55hydrogen ion transmembrane transport (GO:1902600)3.00426241
56viral life cycle (GO:0019058)2.98574519
57regulation of T cell tolerance induction (GO:0002664)2.96261668
58regulation of natural killer cell mediated immunity (GO:0002715)2.94579482
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94579482
60positive regulation of interleukin-8 secretion (GO:2000484)2.94435253
61chaperone-mediated protein transport (GO:0072321)2.93552352
62mast cell activation (GO:0045576)2.93311320
63cellular protein complex disassembly (GO:0043624)2.92465911
64negative regulation of mast cell activation (GO:0033004)2.91529265
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89398809
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89398809
67ATP biosynthetic process (GO:0006754)2.87906822
68sequestering of actin monomers (GO:0042989)2.86342099
69immunoglobulin mediated immune response (GO:0016064)2.83795932
70proton transport (GO:0015992)2.83611147
71translation (GO:0006412)2.83025986
72regulation of cell killing (GO:0031341)2.82774270
73regulation of cellular amino acid metabolic process (GO:0006521)2.82153538
74mitochondrial respiratory chain complex assembly (GO:0033108)2.79806730
75positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79566599
76regulation of interleukin-8 secretion (GO:2000482)2.78531161
77positive regulation of tolerance induction (GO:0002645)2.78393941
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78282659
79hydrogen transport (GO:0006818)2.78067682
80positive regulation of gamma-delta T cell activation (GO:0046645)2.77686000
81response to interferon-beta (GO:0035456)2.76001588
82ribosomal large subunit biogenesis (GO:0042273)2.75511159
83regulation of isotype switching to IgG isotypes (GO:0048302)2.74730698
84pyrimidine nucleoside catabolic process (GO:0046135)2.73991966
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73969420
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.73969420
87NADH dehydrogenase complex assembly (GO:0010257)2.73969420
88negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72848990
89negative thymic T cell selection (GO:0045060)2.72836123
90platelet dense granule organization (GO:0060155)2.70752418
91cytolysis (GO:0019835)2.69896137
92water-soluble vitamin biosynthetic process (GO:0042364)2.69184000
93regulation of alpha-beta T cell proliferation (GO:0046640)2.68520115
94translational initiation (GO:0006413)2.67005798
95positive regulation of defense response to virus by host (GO:0002230)2.66699967
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66187940
97negative regulation of viral genome replication (GO:0045071)2.65012737
98antigen receptor-mediated signaling pathway (GO:0050851)2.64501020
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63757799
100proteasome assembly (GO:0043248)2.63287962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.95925589
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.49628420
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.21971514
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.12034884
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02511594
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95776816
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92469781
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.74599633
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71432582
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67342458
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52877729
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38315198
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36926473
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32896651
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.27881396
16VDR_22108803_ChIP-Seq_LS180_Human2.17934055
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13402314
18VDR_23849224_ChIP-Seq_CD4+_Human2.11354418
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10334387
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01672352
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.01109834
22MYB_26560356_Chip-Seq_TH2_Human2.00331684
23ZNF274_21170338_ChIP-Seq_K562_Hela1.88255138
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85814765
25EZH2_22144423_ChIP-Seq_EOC_Human1.84578653
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.79547695
27ELK1_19687146_ChIP-ChIP_HELA_Human1.70842486
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67290699
29GATA3_26560356_Chip-Seq_TH2_Human1.67152854
30FOXP3_21729870_ChIP-Seq_TREG_Human1.63743397
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59825124
32RUNX_20019798_ChIP-Seq_JUKART_Human1.58992889
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.58786317
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56247004
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48897078
36GATA3_27048872_Chip-Seq_THYMUS_Human1.43142116
37TP53_22573176_ChIP-Seq_HFKS_Human1.42665531
38AR_20517297_ChIP-Seq_VCAP_Human1.39112891
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38935467
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37850499
41MYC_18940864_ChIP-ChIP_HL60_Human1.37248032
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37147028
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36420027
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.36420027
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.35569954
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33043943
47NANOG_20526341_ChIP-Seq_ESCs_Human1.31228892
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29713298
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27961609
50IGF1R_20145208_ChIP-Seq_DFB_Human1.22235759
51TAF2_19829295_ChIP-Seq_ESCs_Human1.21841593
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21279591
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20523898
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19377547
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18806298
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18757846
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18587484
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17567663
59SOX2_19829295_ChIP-Seq_ESCs_Human1.16866403
60NANOG_19829295_ChIP-Seq_ESCs_Human1.16866403
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.16333067
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16223426
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14043699
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13522823
65HTT_18923047_ChIP-ChIP_STHdh_Human1.13445294
66MYB_26560356_Chip-Seq_TH1_Human1.13337635
67ERG_20517297_ChIP-Seq_VCAP_Human1.12567146
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.11884555
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10431861
70NCOR_22424771_ChIP-Seq_293T_Human1.09805701
71EWS_26573619_Chip-Seq_HEK293_Human1.09766580
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09714777
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.06654988
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06608287
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04955461
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.04900640
77MYC_19829295_ChIP-Seq_ESCs_Human1.04495809
78ER_23166858_ChIP-Seq_MCF-7_Human1.03772525
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03377938
80BCL6_27268052_Chip-Seq_Bcells_Human1.03227579
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02645538
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01925892
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00866415
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00631484
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98593625
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97544877
87SPI1_23547873_ChIP-Seq_NB4_Human0.97275099
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97136066
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95765451
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94225936
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93946065
92CTCF_20526341_ChIP-Seq_ESCs_Human0.92519931
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.92333744
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92093973
95P300_19829295_ChIP-Seq_ESCs_Human0.91798123
96BCAT_22108803_ChIP-Seq_LS180_Human0.90957084
97TAF15_26573619_Chip-Seq_HEK293_Human0.90771893
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88817417
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88653144
100RBPJ_21746931_ChIP-Seq_IB4_Human0.88018287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.58631331
2MP0001835_abnormal_antigen_presentation3.75344431
3MP0009785_altered_susceptibility_to3.14482713
4MP0009379_abnormal_foot_pigmentation2.89940476
5MP0009333_abnormal_splenocyte_physiolog2.60212277
6MP0001800_abnormal_humoral_immune2.54749463
7MP0003763_abnormal_thymus_physiology2.48217854
8MP0005000_abnormal_immune_tolerance2.46364168
9MP0003646_muscle_fatigue2.39161838
10MP0000685_abnormal_immune_system2.24430064
11MP0001873_stomach_inflammation2.21864239
12MP0002148_abnormal_hypersensitivity_rea2.13988926
13MP0005387_immune_system_phenotype2.10723991
14MP0001790_abnormal_immune_system2.10723991
15MP0002723_abnormal_immune_serum2.10628073
16MP0005025_abnormal_response_to2.02557504
17MP0006082_CNS_inflammation2.01708262
18MP0002420_abnormal_adaptive_immunity2.00526194
19MP0002166_altered_tumor_susceptibility1.98975205
20MP0001819_abnormal_immune_cell1.97827407
21MP0006072_abnormal_retinal_apoptosis1.96410866
22MP0002452_abnormal_antigen_presenting1.91214319
23MP0003806_abnormal_nucleotide_metabolis1.87551214
24MP0008875_abnormal_xenobiotic_pharmacok1.83649631
25MP0008872_abnormal_physiological_respon1.83384620
26MP0004145_abnormal_muscle_electrophysio1.71268962
27MP0003866_abnormal_defecation1.68962238
28MP0005645_abnormal_hypothalamus_physiol1.67208485
29MP0002006_tumorigenesis1.58172342
30MP0005075_abnormal_melanosome_morpholog1.56736477
31MP0002876_abnormal_thyroid_physiology1.55493824
32MP0002102_abnormal_ear_morphology1.53990115
33MP0010155_abnormal_intestine_physiology1.50947036
34MP0001919_abnormal_reproductive_system1.50140198
35MP0000716_abnormal_immune_system1.48784418
36MP0003436_decreased_susceptibility_to1.43176010
37MP0002277_abnormal_respiratory_mucosa1.42213497
38MP0004147_increased_porphyrin_level1.41429165
39MP0003195_calcinosis1.41225620
40MP0002398_abnormal_bone_marrow1.40571937
41MP0000372_irregular_coat_pigmentation1.40045349
42MP0002138_abnormal_hepatobiliary_system1.39440132
43MP0005389_reproductive_system_phenotype1.36936318
44MP0001905_abnormal_dopamine_level1.36789283
45MP0003011_delayed_dark_adaptation1.35289138
46MP0002837_dystrophic_cardiac_calcinosis1.34288158
47MP0003878_abnormal_ear_physiology1.34238706
48MP0005377_hearing/vestibular/ear_phenot1.34238706
49MP0002933_joint_inflammation1.32902412
50MP0001845_abnormal_inflammatory_respons1.31833411
51MP0001986_abnormal_taste_sensitivity1.31592839
52MP0005551_abnormal_eye_electrophysiolog1.30539662
53MP0002419_abnormal_innate_immunity1.28506298
54MP0002405_respiratory_system_inflammati1.26390214
55MP0003724_increased_susceptibility_to1.25630547
56MP0009764_decreased_sensitivity_to1.23746581
57MP0004885_abnormal_endolymph1.21778774
58MP0001968_abnormal_touch/_nociception1.20092285
59MP0002163_abnormal_gland_morphology1.20069494
60MP0000689_abnormal_spleen_morphology1.18866003
61MP0003786_premature_aging1.17306414
62MP0005646_abnormal_pituitary_gland1.14994720
63MP0006292_abnormal_olfactory_placode1.12938013
64MP0002736_abnormal_nociception_after1.12063191
65MP0002429_abnormal_blood_cell1.11037058
66MP0004142_abnormal_muscle_tone1.09093622
67MP0002722_abnormal_immune_system1.07599673
68MP0005410_abnormal_fertilization1.06572801
69MP0000703_abnormal_thymus_morphology1.02365360
70MP0008469_abnormal_protein_level1.02244084
71MP0008995_early_reproductive_senescence1.01305219
72MP0002095_abnormal_skin_pigmentation1.01050006
73MP0005636_abnormal_mineral_homeostasis1.00120448
74MP0006036_abnormal_mitochondrial_physio0.99187592
75MP0005253_abnormal_eye_physiology0.95577409
76MP0001765_abnormal_ion_homeostasis0.93713524
77MP0008877_abnormal_DNA_methylation0.93556522
78MP0005084_abnormal_gallbladder_morpholo0.91696777
79MP0002160_abnormal_reproductive_system0.87136396
80MP0001533_abnormal_skeleton_physiology0.82679619
81MP0001501_abnormal_sleep_pattern0.81927631
82MP0002693_abnormal_pancreas_physiology0.81168626
83MP0005379_endocrine/exocrine_gland_phen0.80459094
84MP0003638_abnormal_response/metabolism_0.79228488
85MP0005174_abnormal_tail_pigmentation0.77975447
86MP0003137_abnormal_impulse_conducting0.77584624
87MP0009745_abnormal_behavioral_response0.75347507
88MP0001764_abnormal_homeostasis0.75236897
89MP0009763_increased_sensitivity_to0.72959098
90MP0001853_heart_inflammation0.70668712
91MP0005464_abnormal_platelet_physiology0.69843543
92MP0001663_abnormal_digestive_system0.69633524
93MP0004947_skin_inflammation0.69268470
94MP0003448_altered_tumor_morphology0.69114068
95MP0002272_abnormal_nervous_system0.68823605
96MP0009643_abnormal_urine_homeostasis0.67752658
97MP0001542_abnormal_bone_strength0.67546295
98MP0005085_abnormal_gallbladder_physiolo0.67098965
99MP0005166_decreased_susceptibility_to0.67067353
100MP0006276_abnormal_autonomic_nervous0.66764631

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.41131659
2Acute necrotizing encephalopathy (HP:0006965)4.26732541
3Mitochondrial inheritance (HP:0001427)4.21601236
4Aplastic anemia (HP:0001915)4.04568985
5Abnormal mitochondria in muscle tissue (HP:0008316)3.93665437
63-Methylglutaconic aciduria (HP:0003535)3.85398829
7Hypoproteinemia (HP:0003075)3.68517439
8Progressive macrocephaly (HP:0004481)3.58979206
9Hepatocellular necrosis (HP:0001404)3.56044532
10Increased CSF lactate (HP:0002490)3.54292166
11Congenital stationary night blindness (HP:0007642)3.51915187
12Increased hepatocellular lipid droplets (HP:0006565)3.51076927
13Acute encephalopathy (HP:0006846)3.50338055
14Lipid accumulation in hepatocytes (HP:0006561)3.42837263
15T lymphocytopenia (HP:0005403)3.41985047
16Increased intramyocellular lipid droplets (HP:0012240)3.39742714
17Abnormality of T cell number (HP:0011839)3.39541665
18Elevated erythrocyte sedimentation rate (HP:0003565)3.10846504
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08819640
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08819640
21Increased muscle lipid content (HP:0009058)3.06302323
22Hepatic necrosis (HP:0002605)3.01219083
23Severe combined immunodeficiency (HP:0004430)2.98259262
24Congenital, generalized hypertrichosis (HP:0004540)2.96063647
25Renal Fanconi syndrome (HP:0001994)2.94074638
26Stomatitis (HP:0010280)2.91627749
27Increased IgM level (HP:0003496)2.80115998
28Abnormality of B cell number (HP:0010975)2.74828903
29Cerebral edema (HP:0002181)2.74788916
30Abnormality of T cells (HP:0002843)2.73496610
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68170161
32Abnormal number of erythroid precursors (HP:0012131)2.64303116
33Exertional dyspnea (HP:0002875)2.63592478
34Abnormality of the prostate (HP:0008775)2.63318172
35Methylmalonic acidemia (HP:0002912)2.62081512
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58913737
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58844505
38Abnormality of cells of the erythroid lineage (HP:0012130)2.55832272
39Pancreatic cysts (HP:0001737)2.55719991
40Attenuation of retinal blood vessels (HP:0007843)2.55417603
41Optic disc pallor (HP:0000543)2.54769226
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.51832811
43Autoimmune hemolytic anemia (HP:0001890)2.49574027
44Thyroiditis (HP:0100646)2.41390161
45Abnormality of eosinophils (HP:0001879)2.34918624
46B lymphocytopenia (HP:0010976)2.34852043
47Abolished electroretinogram (ERG) (HP:0000550)2.27704353
48Abnormal rod and cone electroretinograms (HP:0008323)2.27335264
49Lactic acidosis (HP:0003128)2.26855829
50Methylmalonic aciduria (HP:0012120)2.26567505
51Constricted visual fields (HP:0001133)2.22910948
52Combined immunodeficiency (HP:0005387)2.22650124
53Increased serum lactate (HP:0002151)2.21109790
54Chronic diarrhea (HP:0002028)2.15823717
55Abnormality of midbrain morphology (HP:0002418)2.14389974
56Molar tooth sign on MRI (HP:0002419)2.14389974
57Macrocytic anemia (HP:0001972)2.14310986
58Respiratory failure (HP:0002878)2.12703914
59Hypoalbuminemia (HP:0003073)2.12375046
60Abnormal albumin level (HP:0012116)2.12375046
61Pulmonary infiltrates (HP:0002113)2.07903534
62Oral leukoplakia (HP:0002745)2.05510486
63Encephalitis (HP:0002383)2.05402263
64Decreased central vision (HP:0007663)2.04216127
65Abnormality of renal resorption (HP:0011038)2.04107507
66IgM deficiency (HP:0002850)2.03277482
67Recurrent bronchitis (HP:0002837)2.02643981
68Pancytopenia (HP:0001876)2.02263508
69Eosinophilia (HP:0001880)2.02000562
70Pancreatic fibrosis (HP:0100732)2.01576326
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.01092320
72Lethargy (HP:0001254)1.98724173
73Leukodystrophy (HP:0002415)1.94858141
74Type 2 muscle fiber atrophy (HP:0003554)1.94115553
75Exercise intolerance (HP:0003546)1.93856580
76True hermaphroditism (HP:0010459)1.92475897
77Meningitis (HP:0001287)1.89851855
78Hemoptysis (HP:0002105)1.88264707
79Panhypogammaglobulinemia (HP:0003139)1.87945464
80Abnormality of T cell physiology (HP:0011840)1.87044480
81Aplasia/hypoplasia of the uterus (HP:0008684)1.84609179
82Vasculitis (HP:0002633)1.83996990
83Abnormality of urine glucose concentration (HP:0011016)1.83648043
84Glycosuria (HP:0003076)1.83648043
85Pallor (HP:0000980)1.82571524
86Chronic mucocutaneous candidiasis (HP:0002728)1.82321397
87Recurrent cutaneous fungal infections (HP:0011370)1.82321397
88Severe visual impairment (HP:0001141)1.80417817
89Hyperphosphaturia (HP:0003109)1.78520417
90Abnormality of the renal cortex (HP:0011035)1.76450475
91Retrobulbar optic neuritis (HP:0100654)1.76385942
92Optic neuritis (HP:0100653)1.76385942
93Leukocytosis (HP:0001974)1.76383346
94Chronic obstructive pulmonary disease (HP:0006510)1.75842030
95Obstructive lung disease (HP:0006536)1.75842030
96Reticulocytopenia (HP:0001896)1.74855313
97Agammaglobulinemia (HP:0004432)1.74719393
98Type I transferrin isoform profile (HP:0003642)1.73117820
99Stomach cancer (HP:0012126)1.72453699
100Lymphopenia (HP:0001888)1.72124859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.58786928
2KDR4.25086043
3TESK23.99574109
4TAOK32.78465503
5VRK22.76735410
6TLK12.75049733
7MAP3K122.49008587
8ZAK2.48822975
9MAP4K12.46735134
10BCKDK2.37046613
11ADRBK22.34246084
12GRK12.13784256
13MAP4K22.03828530
14ITK1.94443411
15NUAK11.93627147
16CDK191.93327737
17KIT1.83818086
18TEC1.82581129
19SCYL21.64650894
20SYK1.64311914
21MST41.62978098
22LIMK11.58225044
23FES1.57892656
24MUSK1.53308834
25GRK61.52178545
26STK161.49480596
27VRK11.42865171
28PASK1.40628877
29MYLK1.37555216
30IKBKB1.31340499
31FRK1.30125243
32PINK11.21020331
33BMPR21.18376178
34BTK1.14490392
35TESK11.10629660
36CSF1R1.09146155
37IKBKE1.07817497
38WNK41.07815570
39LCK1.04889066
40LYN1.01314623
41INSRR1.00423047
42GRK70.99676306
43CSK0.98875306
44PRKCQ0.97914773
45ZAP700.88219663
46TIE10.86528197
47PIK3CG0.84289738
48OXSR10.84041414
49DAPK10.83701047
50NME10.80947985
51TNK20.80713986
52BUB10.79003284
53RPS6KA50.74632813
54ADRBK10.70271981
55OBSCN0.69234040
56WNK30.69152961
57MAPKAPK30.68250667
58MAP3K110.67537077
59CAMKK20.65703597
60MAP2K60.65196698
61DYRK20.64713069
62EIF2AK30.58723957
63IGF1R0.55649321
64PIM10.55615021
65RIPK40.54827186
66MATK0.53753601
67JAK30.53619153
68CAMKK10.53542082
69DAPK30.52497749
70ILK0.50228607
71GRK50.48153958
72DAPK20.45836229
73PRKCA0.45653518
74PRKACA0.45548899
75HCK0.45016274
76PIK3CA0.44486265
77FLT30.43707673
78ROCK10.43193158
79ERBB30.42968796
80TRPM70.41987175
81TBK10.40194571
82BMPR1B0.38381660
83CDK80.37530287
84CSNK2A10.37206829
85FYN0.35331893
86CSNK1G30.35272296
87PRKCE0.34278988
88INSR0.34270020
89PRKCH0.34183363
90CSNK2A20.33416990
91PHKG10.31674150
92PHKG20.31674150
93ABL10.31512225
94STK390.28956077
95PLK40.28156540
96CAMK2A0.28047809
97MAP2K20.27944245
98EGFR0.26405534
99MAPK130.26297728
100AURKB0.25814476

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.77090233
2Primary immunodeficiency_Homo sapiens_hsa053403.72703778
3Ribosome_Homo sapiens_hsa030103.62135140
4Proteasome_Homo sapiens_hsa030503.50783446
5Allograft rejection_Homo sapiens_hsa053303.41312532
6Autoimmune thyroid disease_Homo sapiens_hsa053203.36313750
7Graft-versus-host disease_Homo sapiens_hsa053323.35358546
8Asthma_Homo sapiens_hsa053103.22962205
9Parkinsons disease_Homo sapiens_hsa050123.03120738
10Type I diabetes mellitus_Homo sapiens_hsa049402.75568779
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.68821495
12Antigen processing and presentation_Homo sapiens_hsa046122.53253037
13Alzheimers disease_Homo sapiens_hsa050102.10446759
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96330904
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89141710
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87425656
17Huntingtons disease_Homo sapiens_hsa050161.86283766
18Protein export_Homo sapiens_hsa030601.85912662
19Hematopoietic cell lineage_Homo sapiens_hsa046401.83692810
20RNA polymerase_Homo sapiens_hsa030201.82347207
21Cardiac muscle contraction_Homo sapiens_hsa042601.73507050
22Rheumatoid arthritis_Homo sapiens_hsa053231.73198485
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59175844
24Phototransduction_Homo sapiens_hsa047441.51604069
25Viral myocarditis_Homo sapiens_hsa054161.45505862
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37640571
27T cell receptor signaling pathway_Homo sapiens_hsa046601.22158518
28Homologous recombination_Homo sapiens_hsa034401.21822320
29Staphylococcus aureus infection_Homo sapiens_hsa051501.15062798
30Linoleic acid metabolism_Homo sapiens_hsa005911.08615521
31Caffeine metabolism_Homo sapiens_hsa002321.05394475
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05103342
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03617187
34Systemic lupus erythematosus_Homo sapiens_hsa053221.00503688
35Nitrogen metabolism_Homo sapiens_hsa009100.98975768
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98095905
37RNA degradation_Homo sapiens_hsa030180.92640795
38One carbon pool by folate_Homo sapiens_hsa006700.86550387
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.83499128
40Olfactory transduction_Homo sapiens_hsa047400.79768267
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78403540
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78036457
43Chemical carcinogenesis_Homo sapiens_hsa052040.76160307
44Pyrimidine metabolism_Homo sapiens_hsa002400.72616472
45Leishmaniasis_Homo sapiens_hsa051400.71828700
46Retinol metabolism_Homo sapiens_hsa008300.70023582
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.68764891
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65241363
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64189326
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.62897218
51Mismatch repair_Homo sapiens_hsa034300.62746690
52Purine metabolism_Homo sapiens_hsa002300.62041964
53Tryptophan metabolism_Homo sapiens_hsa003800.61261688
54DNA replication_Homo sapiens_hsa030300.59354032
55Nucleotide excision repair_Homo sapiens_hsa034200.59261014
56Malaria_Homo sapiens_hsa051440.58888244
57Measles_Homo sapiens_hsa051620.58238676
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57704660
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57075479
60Arachidonic acid metabolism_Homo sapiens_hsa005900.53146630
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.52288529
62Basal transcription factors_Homo sapiens_hsa030220.52158133
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51615303
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51095704
65Peroxisome_Homo sapiens_hsa041460.50942876
66Spliceosome_Homo sapiens_hsa030400.50413028
67Nicotine addiction_Homo sapiens_hsa050330.49755240
68Sulfur metabolism_Homo sapiens_hsa009200.49001410
69Herpes simplex infection_Homo sapiens_hsa051680.48280897
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.47362017
71Fanconi anemia pathway_Homo sapiens_hsa034600.47108268
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44083698
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42700689
74Regulation of autophagy_Homo sapiens_hsa041400.41363404
75Collecting duct acid secretion_Homo sapiens_hsa049660.41324878
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41319316
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40715218
78Metabolic pathways_Homo sapiens_hsa011000.36369749
79Taste transduction_Homo sapiens_hsa047420.36020760
80Propanoate metabolism_Homo sapiens_hsa006400.33738586
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32754480
82Base excision repair_Homo sapiens_hsa034100.32522811
83Vitamin digestion and absorption_Homo sapiens_hsa049770.30692214
84Ether lipid metabolism_Homo sapiens_hsa005650.29295451
85Morphine addiction_Homo sapiens_hsa050320.28265551
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27611134
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26743073
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26296211
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25757915
90Epstein-Barr virus infection_Homo sapiens_hsa051690.24453650
91Fat digestion and absorption_Homo sapiens_hsa049750.24164406
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23838774
93Salmonella infection_Homo sapiens_hsa051320.21911178
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.21021970
95Tyrosine metabolism_Homo sapiens_hsa003500.19174735
96Tuberculosis_Homo sapiens_hsa051520.18896857
97Butanoate metabolism_Homo sapiens_hsa006500.18584130
98RNA transport_Homo sapiens_hsa030130.17213992
99African trypanosomiasis_Homo sapiens_hsa051430.16401684
100Mineral absorption_Homo sapiens_hsa049780.15226482

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