ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.38296347
2	S-adenosylmethionine metabolic process (GO:0046500)	4.11507261
3	protein complex biogenesis (GO:0070271)	3.90908312
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.75324367
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.66411852
6	cytochrome complex assembly (GO:0017004)	3.65054637
7	protein prenylation (GO:0018342)	3.63576742
8	prenylation (GO:0097354)	3.63576742
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.61231926
10	ATP synthesis coupled proton transport (GO:0015986)	3.61231926
11	respiratory chain complex IV assembly (GO:0008535)	3.55401670
12	indole-containing compound catabolic process (GO:0042436)	3.54266050
13	indolalkylamine catabolic process (GO:0046218)	3.54266050
14	tryptophan catabolic process (GO:0006569)	3.54266050
15	mitochondrial respiratory chain complex assembly (GO:0033108)	3.49912250
16	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.40175432
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.40175432
18	protein K11-linked deubiquitination (GO:0035871)	3.39072302
19	kynurenine metabolic process (GO:0070189)	3.32950711
20	respiratory electron transport chain (GO:0022904)	3.26450072
21	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.26297795
22	termination of RNA polymerase III transcription (GO:0006386)	3.26297795
23	electron transport chain (GO:0022900)	3.25698875
24	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.20969672
25	piRNA metabolic process (GO:0034587)	3.16302103
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.12660683
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.12660683
28	NADH dehydrogenase complex assembly (GO:0010257)	3.12660683
29	mannosylation (GO:0097502)	3.11625312
30	response to pheromone (GO:0019236)	3.09984341
31	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08396779
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06111150
33	indolalkylamine metabolic process (GO:0006586)	3.02935071
34	regulation of cilium movement (GO:0003352)	3.02071770
35	cellular ketone body metabolic process (GO:0046950)	3.00929736
36	inositol phosphate catabolic process (GO:0071545)	2.99212924
37	L-fucose catabolic process (GO:0042355)	2.98522848
38	fucose catabolic process (GO:0019317)	2.98522848
39	L-fucose metabolic process (GO:0042354)	2.98522848
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98456221
41	GPI anchor metabolic process (GO:0006505)	2.97606765
42	mast cell activation (GO:0045576)	2.93753361
43	tryptophan metabolic process (GO:0006568)	2.93692085
44	GPI anchor biosynthetic process (GO:0006506)	2.86947911
45	platelet dense granule organization (GO:0060155)	2.84450105
46	detection of light stimulus involved in sensory perception (GO:0050962)	2.82835585
47	detection of light stimulus involved in visual perception (GO:0050908)	2.82835585
48	resolution of meiotic recombination intermediates (GO:0000712)	2.81561398
49	axoneme assembly (GO:0035082)	2.81298380
50	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.80683766
51	inositol phosphate dephosphorylation (GO:0046855)	2.80683766
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.80095953
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.80095953
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.76942545
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.75158445
56	aggressive behavior (GO:0002118)	2.74907515
57	behavioral response to nicotine (GO:0035095)	2.73390635
58	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.72866841
59	chaperone-mediated protein transport (GO:0072321)	2.70164898
60	ketone body metabolic process (GO:1902224)	2.68874206
61	negative regulation of mast cell activation (GO:0033004)	2.68154164
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.64508789
63	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.61942664
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61529397
65	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.61319635
66	isotype switching (GO:0045190)	2.61319635
67	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.61319635
68	pseudouridine synthesis (GO:0001522)	2.60892274
69	synapsis (GO:0007129)	2.60805922
70	ribosomal small subunit assembly (GO:0000028)	2.60308115
71	positive regulation of defense response to virus by host (GO:0002230)	2.59473806
72	proton transport (GO:0015992)	2.52419880
73	hydrogen ion transmembrane transport (GO:1902600)	2.50302691
74	hydrogen transport (GO:0006818)	2.47336512
75	recombinational repair (GO:0000725)	2.47276699
76	adenosine metabolic process (GO:0046085)	2.45437375
77	mast cell degranulation (GO:0043303)	2.43799717
78	mast cell activation involved in immune response (GO:0002279)	2.43799717
79	protein-cofactor linkage (GO:0018065)	2.43798127
80	regulation of cellular amino acid metabolic process (GO:0006521)	2.42552463
81	double-strand break repair via homologous recombination (GO:0000724)	2.42307616
82	proteasome assembly (GO:0043248)	2.42215208
83	immunoglobulin mediated immune response (GO:0016064)	2.42204884
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.41415800
85	protein neddylation (GO:0045116)	2.41228604
86	regulation of germinal center formation (GO:0002634)	2.39934338
87	interferon-gamma production (GO:0032609)	2.39388862
88	neural tube formation (GO:0001841)	2.39146846
89	cytidine metabolic process (GO:0046087)	2.38095832
90	cytidine catabolic process (GO:0006216)	2.38095832
91	cytidine deamination (GO:0009972)	2.38095832
92	leukocyte aggregation (GO:0070486)	2.37942042
93	regulation of regulatory T cell differentiation (GO:0045589)	2.37208696
94	cellular biogenic amine catabolic process (GO:0042402)	2.37126707
95	amine catabolic process (GO:0009310)	2.37126707
96	DNA double-strand break processing (GO:0000729)	2.36422119
97	cilium morphogenesis (GO:0060271)	2.33941686
98	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.33759599
99	aldehyde catabolic process (GO:0046185)	2.33320467
100	C-terminal protein lipidation (GO:0006501)	2.31801233

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.79933191
2	VDR_22108803_ChIP-Seq_LS180_Human	3.34920265
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22083313
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.94740110
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78003905
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.70989957
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.59495902
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.51155508
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.47820864
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41469008
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.16609984
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15540349
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12563140
14	EWS_26573619_Chip-Seq_HEK293_Human	2.08914886
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.04922749
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03816221
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.96026419
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.95613450
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.91748610
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.90963357
21	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.80935513
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80751463
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.80429642
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.79599778
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.78274494
26	FUS_26573619_Chip-Seq_HEK293_Human	1.76511738
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68123071
28	P300_19829295_ChIP-Seq_ESCs_Human	1.67491284
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66850733
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63801558
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.62838826
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55812031
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.53332872
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.52436476
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.52436476
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52325973
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50297035
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.49761178
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49295121
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.48963259
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.48325535
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.47965602
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47965602
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.45830037
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.44764589
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44515893
47	AR_20517297_ChIP-Seq_VCAP_Human	1.43070379
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43049476
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43049476
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41117363
51	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.40996480
52	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.40748915
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40448805
54	GATA3_26560356_Chip-Seq_TH2_Human	1.36998993
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35859149
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27292650
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25524919
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24982356
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24698233
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.24678782
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24551935
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.22623008
63	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.20295253
64	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.19607810
65	NCOR_22424771_ChIP-Seq_293T_Human	1.19154285
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18833419
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.18365134
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17771000
69	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.16690304
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16673528
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16429733
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.16207185
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13935354
74	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13676230
75	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.13622350
76	AR_25329375_ChIP-Seq_VCAP_Human	1.12681127
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11456576
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09872361
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08562260
80	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07826639
81	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07824556
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07135256
83	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06408271
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06156618
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.04975090
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.04573146
87	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.04144274
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03935251
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03091063
90	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03013933
91	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02981091
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02655121
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02498585
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02276578
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01528743
96	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.01031789
97	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00608983
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00455510
99	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00254264
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.99612082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.47794370
2	MP0004147_increased_porphyrin_level	3.27951453
3	MP0008877_abnormal_DNA_methylation	3.27494660
4	MP0006072_abnormal_retinal_apoptosis	2.95604872
5	MP0001835_abnormal_antigen_presentation	2.80206604
6	MP0005367_renal/urinary_system_phenotyp	2.65793576
7	MP0000516_abnormal_urinary_system	2.65793576
8	MP0003195_calcinosis	2.63205000
9	MP0002102_abnormal_ear_morphology	2.54834561
10	MP0003646_muscle_fatigue	2.53881951
11	MP0005551_abnormal_eye_electrophysiolog	2.39964134
12	MP0008872_abnormal_physiological_respon	2.01363339
13	MP0003787_abnormal_imprinting	1.95331193
14	MP0003724_increased_susceptibility_to	1.90167460
15	MP0005645_abnormal_hypothalamus_physiol	1.88644092
16	MP0005253_abnormal_eye_physiology	1.83971929
17	MP0002638_abnormal_pupillary_reflex	1.80949602
18	MP0002837_dystrophic_cardiac_calcinosis	1.79449459
19	MP0008875_abnormal_xenobiotic_pharmacok	1.72894897
20	MP0001968_abnormal_touch/_nociception	1.72266668
21	MP0002166_altered_tumor_susceptibility	1.71595787
22	MP0002160_abnormal_reproductive_system	1.69413088
23	MP0005646_abnormal_pituitary_gland	1.67960203
24	MP0009785_altered_susceptibility_to	1.66703535
25	MP0006292_abnormal_olfactory_placode	1.65069434
26	MP0001984_abnormal_olfaction	1.59025393
27	MP0002736_abnormal_nociception_after	1.58091572
28	MP0003786_premature_aging	1.57344071
29	MP0005389_reproductive_system_phenotype	1.56512552
30	MP0001919_abnormal_reproductive_system	1.54156337
31	MP0001800_abnormal_humoral_immune	1.51074278
32	MP0004145_abnormal_muscle_electrophysio	1.47696496
33	MP0005075_abnormal_melanosome_morpholog	1.45750835
34	MP0003011_delayed_dark_adaptation	1.44610084
35	MP0005410_abnormal_fertilization	1.39375171
36	MP0002006_tumorigenesis	1.32906852
37	MP0000372_irregular_coat_pigmentation	1.28651564
38	MP0005000_abnormal_immune_tolerance	1.28589340
39	MP0003880_abnormal_central_pattern	1.28447348
40	MP0009764_decreased_sensitivity_to	1.27010555
41	MP0003718_maternal_effect	1.26705706
42	MP0006036_abnormal_mitochondrial_physio	1.25091072
43	MP0002148_abnormal_hypersensitivity_rea	1.24854934
44	MP0004142_abnormal_muscle_tone	1.24588883
45	MP0001905_abnormal_dopamine_level	1.23919611
46	MP0001986_abnormal_taste_sensitivity	1.23416360
47	MP0000685_abnormal_immune_system	1.22949853
48	MP0005084_abnormal_gallbladder_morpholo	1.20536377
49	MP0003763_abnormal_thymus_physiology	1.19792918
50	MP0002277_abnormal_respiratory_mucosa	1.18841890
51	MP0004885_abnormal_endolymph	1.18730260
52	MP0002138_abnormal_hepatobiliary_system	1.18508321
53	MP0008058_abnormal_DNA_repair	1.17881939
54	MP0003806_abnormal_nucleotide_metabolis	1.17584632
55	MP0009046_muscle_twitch	1.16415317
56	MP0002723_abnormal_immune_serum	1.14674648
57	MP0002452_abnormal_antigen_presenting	1.14136143
58	MP0003137_abnormal_impulse_conducting	1.11759381
59	MP0002876_abnormal_thyroid_physiology	1.10832042
60	MP0009745_abnormal_behavioral_response	1.09984949
61	MP0004043_abnormal_pH_regulation	1.09791138
62	MP0002272_abnormal_nervous_system	1.09416306
63	MP0002163_abnormal_gland_morphology	1.08591450
64	MP0004215_abnormal_myocardial_fiber	1.06422781
65	MP0002751_abnormal_autonomic_nervous	1.02658896
66	MP0002282_abnormal_trachea_morphology	1.02389994
67	MP0001819_abnormal_immune_cell	1.01800785
68	MP0000427_abnormal_hair_cycle	1.01708455
69	MP0003045_fibrosis	1.01372403
70	MP0006276_abnormal_autonomic_nervous	1.00919992
71	MP0003252_abnormal_bile_duct	1.00136192
72	MP0002420_abnormal_adaptive_immunity	0.98368535
73	MP0009333_abnormal_splenocyte_physiolog	0.97970866
74	MP0005636_abnormal_mineral_homeostasis	0.94307773
75	MP0008995_early_reproductive_senescence	0.91146304
76	MP0005085_abnormal_gallbladder_physiolo	0.88484204
77	MP0001485_abnormal_pinna_reflex	0.88157537
78	MP0005623_abnormal_meninges_morphology	0.87775715
79	MP0001529_abnormal_vocalization	0.87241358
80	MP0000013_abnormal_adipose_tissue	0.86238037
81	MP0001486_abnormal_startle_reflex	0.86206614
82	MP0002234_abnormal_pharynx_morphology	0.84482110
83	MP0002938_white_spotting	0.81975171
84	MP0000631_abnormal_neuroendocrine_gland	0.77973411
85	MP0005332_abnormal_amino_acid	0.75885254
86	MP0001119_abnormal_female_reproductive	0.75822625
87	MP0005025_abnormal_response_to	0.73911455
88	MP0010386_abnormal_urinary_bladder	0.73866755
89	MP0008789_abnormal_olfactory_epithelium	0.73629593
90	MP0010094_abnormal_chromosome_stability	0.73074264
91	MP0001929_abnormal_gametogenesis	0.72791676
92	MP0001765_abnormal_ion_homeostasis	0.72604484
93	MP0005379_endocrine/exocrine_gland_phen	0.71729471
94	MP0001970_abnormal_pain_threshold	0.71616653
95	MP0001845_abnormal_inflammatory_respons	0.71460038
96	MP0001501_abnormal_sleep_pattern	0.70209929
97	MP0005387_immune_system_phenotype	0.69121998
98	MP0001790_abnormal_immune_system	0.69121998
99	MP0005195_abnormal_posterior_eye	0.69060649
100	MP0006082_CNS_inflammation	0.68636280

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.94023614
2	Cerebellar dysplasia (HP:0007033)	4.16968611
3	Abolished electroretinogram (ERG) (HP:0000550)	4.02821375
4	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.86003921
5	Hepatocellular necrosis (HP:0001404)	3.79131139
6	Mitochondrial inheritance (HP:0001427)	3.73188856
7	IgG deficiency (HP:0004315)	3.71660635
8	Acute necrotizing encephalopathy (HP:0006965)	3.62716172
9	Hepatic necrosis (HP:0002605)	3.61168612
10	Progressive macrocephaly (HP:0004481)	3.60076155
11	Increased CSF lactate (HP:0002490)	3.46431863
12	Increased hepatocellular lipid droplets (HP:0006565)	3.44116926
13	Molar tooth sign on MRI (HP:0002419)	3.43745502
14	Abnormality of midbrain morphology (HP:0002418)	3.43745502
15	Lipid accumulation in hepatocytes (HP:0006561)	3.34991510
16	Exertional dyspnea (HP:0002875)	3.29114737
17	Pancreatic cysts (HP:0001737)	3.28932316
18	Congenital, generalized hypertrichosis (HP:0004540)	3.23050606
19	Abnormal mitochondria in muscle tissue (HP:0008316)	3.15566474
20	Fatigue (HP:0012378)	3.13467743
21	Hypoproteinemia (HP:0003075)	3.10935461
22	B lymphocytopenia (HP:0010976)	2.99895979
23	Congenital stationary night blindness (HP:0007642)	2.99477589
24	Retinal dysplasia (HP:0007973)	2.99209602
25	Thyroiditis (HP:0100646)	2.96298792
26	Hypoplasia of the pons (HP:0012110)	2.95194034
27	Abnormality of the pons (HP:0007361)	2.94056817
28	3-Methylglutaconic aciduria (HP:0003535)	2.93829933
29	Acute encephalopathy (HP:0006846)	2.93598793
30	Retinal atrophy (HP:0001105)	2.92799598
31	Nephronophthisis (HP:0000090)	2.90720948
32	Abnormality of B cell number (HP:0010975)	2.88535092
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81119335
34	Renal Fanconi syndrome (HP:0001994)	2.73540224
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.71475532
36	Elevated erythrocyte sedimentation rate (HP:0003565)	2.68678796
37	Abnormality of the renal cortex (HP:0011035)	2.66575071
38	Pancreatic fibrosis (HP:0100732)	2.65472007
39	True hermaphroditism (HP:0010459)	2.63133754
40	Stomatitis (HP:0010280)	2.53047527
41	Severe combined immunodeficiency (HP:0004430)	2.52417233
42	Abnormality of the renal medulla (HP:0100957)	2.51384749
43	Attenuation of retinal blood vessels (HP:0007843)	2.43477023
44	Renal cortical cysts (HP:0000803)	2.38168802
45	Hypothermia (HP:0002045)	2.36937779
46	Increased intramyocellular lipid droplets (HP:0012240)	2.31427892
47	Cerebral edema (HP:0002181)	2.30092050
48	Abnormal drinking behavior (HP:0030082)	2.25268547
49	Polydipsia (HP:0001959)	2.25268547
50	Respiratory failure (HP:0002878)	2.25075125
51	Decreased central vision (HP:0007663)	2.21283326
52	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.19049071
53	Generalized aminoaciduria (HP:0002909)	2.17833394
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13479180
55	Increased serum lactate (HP:0002151)	2.13085381
56	Abnormality of urine glucose concentration (HP:0011016)	2.12242832
57	Glycosuria (HP:0003076)	2.12242832
58	Aplastic anemia (HP:0001915)	2.11121660
59	Erythroderma (HP:0001019)	2.04477430
60	Optic disc pallor (HP:0000543)	2.02677750
61	Medial flaring of the eyebrow (HP:0010747)	2.02072839
62	Lissencephaly (HP:0001339)	1.98398154
63	Increased muscle lipid content (HP:0009058)	1.96073072
64	Absent/shortened dynein arms (HP:0200106)	1.95937362
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.95937362
66	CNS demyelination (HP:0007305)	1.92897930
67	Abnormality of the prostate (HP:0008775)	1.91099477
68	Lactic acidosis (HP:0003128)	1.90807440
69	Papilledema (HP:0001085)	1.90564722
70	Severe muscular hypotonia (HP:0006829)	1.90352780
71	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89584023
72	Progressive microcephaly (HP:0000253)	1.86862313
73	Cystic liver disease (HP:0006706)	1.86462081
74	Hypoalbuminemia (HP:0003073)	1.82518665
75	Abnormal albumin level (HP:0012116)	1.82518665
76	Asplenia (HP:0001746)	1.81718099
77	Polyuria (HP:0000103)	1.77347829
78	Combined immunodeficiency (HP:0005387)	1.77179496
79	Type I transferrin isoform profile (HP:0003642)	1.76607384
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75828868
81	Sclerocornea (HP:0000647)	1.75351490
82	Abnormality of renal resorption (HP:0011038)	1.73449959
83	Abnormality of eosinophils (HP:0001879)	1.72557255
84	Panhypogammaglobulinemia (HP:0003139)	1.72433194
85	Conjunctival hamartoma (HP:0100780)	1.72229077
86	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.71151940
87	Abnormality of alanine metabolism (HP:0010916)	1.70782449
88	Hyperalaninemia (HP:0003348)	1.70782449
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.70782449
90	Chronic hepatic failure (HP:0100626)	1.70476046
91	Methylmalonic acidemia (HP:0002912)	1.70354530
92	Furrowed tongue (HP:0000221)	1.69262317
93	Alveolar cell carcinoma (HP:0006519)	1.66206489
94	Bile duct proliferation (HP:0001408)	1.65800567
95	Abnormal biliary tract physiology (HP:0012439)	1.65800567
96	Leukodystrophy (HP:0002415)	1.65533377
97	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.65408887
98	Macular degeneration (HP:0000608)	1.64869482
99	Colon cancer (HP:0003003)	1.64403402
100	Optic nerve hypoplasia (HP:0000609)	1.63757071

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.22211684
2	TXK	3.24322837
3	MAP4K2	2.97111289
4	TLK1	2.51132221
5	MARK3	2.50477513
6	MAP3K12	2.38482091
7	GRK1	2.35391888
8	TAOK3	2.34735057
9	MST4	2.18035312
10	WNK3	1.88247218
11	BMPR2	1.87475330
12	NUAK1	1.74037144
13	STK10	1.62822924
14	ERBB3	1.61864505
15	ADRBK2	1.60107636
16	TNIK	1.56035087
17	EIF2AK3	1.53556106
18	PLK4	1.51937332
19	CDK19	1.46812545
20	NLK	1.44986552
21	ZAK	1.44580937
22	BCKDK	1.40514065
23	BRSK2	1.34921887
24	TEC	1.33602486
25	TRPM7	1.32530430
26	VRK2	1.27573454
27	KDR	1.26847998
28	PINK1	1.21067857
29	PIK3CG	1.20079906
30	FGFR2	1.16393473
31	AKT3	1.14087164
32	ITK	1.13245371
33	PTK2B	1.11987411
34	VRK1	1.10650026
35	IKBKB	1.09037977
36	MYLK	1.08548915
37	MAP3K4	1.08432844
38	MAP4K1	1.07541577
39	OXSR1	1.05228978
40	TIE1	1.00189069
41	KIT	1.00062352
42	CSNK1G3	0.96621734
43	GRK6	0.95997527
44	INSRR	0.95191240
45	PLK3	0.95144053
46	WNK4	0.93666282
47	BUB1	0.84588940
48	FLT3	0.83652489
49	MAPKAPK3	0.82945856
50	CSNK1G1	0.81540603
51	BMPR1B	0.80980899
52	SRPK1	0.80789614
53	MAPK13	0.80222422
54	STK11	0.77778894
55	PLK2	0.77755668
56	EPHA3	0.77276380
57	DYRK2	0.76754414
58	PNCK	0.76585936
59	EIF2AK1	0.76178584
60	STK24	0.75757890
61	MUSK	0.74306315
62	FES	0.72697912
63	PRKCE	0.70125412
64	CSNK1A1L	0.69065440
65	MAP2K7	0.68926411
66	PASK	0.68556115
67	LYN	0.68266038
68	CSNK1G2	0.67631404
69	PRKCQ	0.66538398
70	PHKG2	0.66521619
71	PHKG1	0.66521619
72	NEK1	0.61140457
73	STK38L	0.60926089
74	CAMKK2	0.60398222
75	BTK	0.59936414
76	SYK	0.58757636
77	TRIM28	0.58279633
78	CDK8	0.57697501
79	PIM1	0.57650257
80	LCK	0.57129115
81	ILK	0.56674159
82	WEE1	0.55859076
83	CDK9	0.55637440
84	PKN1	0.54437088
85	CSF1R	0.53724774
86	DAPK1	0.52978692
87	MAPKAPK5	0.51307748
88	MKNK1	0.50160018
89	EPHA4	0.46105271
90	OBSCN	0.45935887
91	IGF1R	0.44900000
92	MAP2K2	0.43461133
93	PRKCG	0.43288535
94	RPS6KA5	0.42683636
95	NME1	0.41456869
96	EIF2AK2	0.41405910
97	TESK2	0.39024222
98	MAP2K6	0.38182376
99	CSNK2A1	0.37965888
100	TNK2	0.37867500

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.10698124
2	Allograft rejection_Homo sapiens_hsa05330	3.37466659
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.34330661
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.26486416
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.09243645
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.02149271
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.99780713
8	Proteasome_Homo sapiens_hsa03050	2.74810476
9	Protein export_Homo sapiens_hsa03060	2.58976941
10	Parkinsons disease_Homo sapiens_hsa05012	2.24684624
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08660962
12	RNA polymerase_Homo sapiens_hsa03020	2.07371313
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.03118033
14	Ribosome_Homo sapiens_hsa03010	1.91099235
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.88921694
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.79946254
17	Homologous recombination_Homo sapiens_hsa03440	1.78682497
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.77317035
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74480635
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.58786051
21	Phototransduction_Homo sapiens_hsa04744	1.57214765
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54772054
23	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.49302995
24	Viral myocarditis_Homo sapiens_hsa05416	1.46623084
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42088476
26	Alzheimers disease_Homo sapiens_hsa05010	1.36470795
27	Huntingtons disease_Homo sapiens_hsa05016	1.35334649
28	RNA degradation_Homo sapiens_hsa03018	1.33522187
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28592201
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23194945
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18923886
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15907416
33	Butanoate metabolism_Homo sapiens_hsa00650	1.13262423
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09917887
35	Leishmaniasis_Homo sapiens_hsa05140	1.09048695
36	Caffeine metabolism_Homo sapiens_hsa00232	1.08096450
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.07559430
38	One carbon pool by folate_Homo sapiens_hsa00670	1.07473742
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.06265321
40	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.06132666
41	Basal transcription factors_Homo sapiens_hsa03022	1.05813876
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05345602
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01338720
44	Regulation of autophagy_Homo sapiens_hsa04140	0.96572670
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96333328
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.94813617
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89109128
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89092854
49	Mismatch repair_Homo sapiens_hsa03430	0.85859939
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81158725
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80511624
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79792022
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77967713
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75970397
55	Sulfur metabolism_Homo sapiens_hsa00920	0.75342892
56	Olfactory transduction_Homo sapiens_hsa04740	0.72052543
57	Purine metabolism_Homo sapiens_hsa00230	0.72005893
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.71533382
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70752782
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70537495
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69473108
62	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68688241
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68591583
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66607962
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66089698
66	RNA transport_Homo sapiens_hsa03013	0.66074216
67	Peroxisome_Homo sapiens_hsa04146	0.65444252
68	DNA replication_Homo sapiens_hsa03030	0.65284691
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64115511
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64000970
71	Taste transduction_Homo sapiens_hsa04742	0.63939913
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62826283
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.57091455
74	Retinol metabolism_Homo sapiens_hsa00830	0.56748743
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55478522
76	Propanoate metabolism_Homo sapiens_hsa00640	0.52040657
77	Herpes simplex infection_Homo sapiens_hsa05168	0.51779837
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51510271
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49014660
80	Spliceosome_Homo sapiens_hsa03040	0.44833696
81	Toxoplasmosis_Homo sapiens_hsa05145	0.44519233
82	Metabolic pathways_Homo sapiens_hsa01100	0.39740971
83	Fatty acid elongation_Homo sapiens_hsa00062	0.39578118
84	Tuberculosis_Homo sapiens_hsa05152	0.39089381
85	Base excision repair_Homo sapiens_hsa03410	0.37876367
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36625740
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35972407
88	Nicotine addiction_Homo sapiens_hsa05033	0.33123567
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.32631076
90	Phagosome_Homo sapiens_hsa04145	0.31661576
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31569053
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27668613
93	Fatty acid degradation_Homo sapiens_hsa00071	0.24168083
94	Serotonergic synapse_Homo sapiens_hsa04726	0.22905880
95	Salivary secretion_Homo sapiens_hsa04970	0.20028833
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19733327
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.18741380
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.17857641
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.17736488
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.16956326

RPL23AP58

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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