ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of isotype switching to IgG isotypes (GO:0048302)	7.18603603
2	purine ribonucleotide transport (GO:0015868)	6.82721471
3	adenine nucleotide transport (GO:0051503)	6.78928496
4	nucleotide transmembrane transport (GO:1901679)	6.39130256
5	chaperone-mediated protein transport (GO:0072321)	6.28173751
6	purine nucleotide transport (GO:0015865)	5.97218337
7	otic vesicle formation (GO:0030916)	5.88687451
8	heme transport (GO:0015886)	5.81828610
9	ATP synthesis coupled proton transport (GO:0015986)	5.66783633
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.66783633
11	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	5.60310848
12	cellular response to ATP (GO:0071318)	5.36604611
13	nucleoside transmembrane transport (GO:1901642)	5.33585827
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.31994886
15	phosphatidylcholine acyl-chain remodeling (GO:0036151)	5.24625241
16	protein K63-linked deubiquitination (GO:0070536)	5.20380815
17	surfactant homeostasis (GO:0043129)	5.10723868
18	regulation of phospholipid biosynthetic process (GO:0071071)	5.05626853
19	negative regulation of type 2 immune response (GO:0002829)	4.86018807
20	positive regulation of T-helper 1 type immune response (GO:0002827)	4.62552389
21	cofactor transport (GO:0051181)	4.62123769
22	DNA deamination (GO:0045006)	4.44682557
23	protein neddylation (GO:0045116)	4.39043913
24	maturation of SSU-rRNA (GO:0030490)	4.33078527
25	iron coordination entity transport (GO:1901678)	4.28877066
26	chemical homeostasis within a tissue (GO:0048875)	4.12882082
27	negative regulation of telomerase activity (GO:0051974)	4.09541290
28	negative regulation of telomere maintenance (GO:0032205)	4.05851193
29	folic acid transport (GO:0015884)	4.03301638
30	water-soluble vitamin biosynthetic process (GO:0042364)	4.01490323
31	male meiosis I (GO:0007141)	3.91221412
32	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.91195004
33	organic cation transport (GO:0015695)	3.89230386
34	nucleotide transport (GO:0006862)	3.86055362
35	viral transcription (GO:0019083)	3.85277955
36	limb bud formation (GO:0060174)	3.82941141
37	folic acid-containing compound biosynthetic process (GO:0009396)	3.78176661
38	translational termination (GO:0006415)	3.73047566
39	negative regulation of multicellular organism growth (GO:0040015)	3.72484637
40	nucleoside transport (GO:0015858)	3.67219462
41	telomere maintenance via telomerase (GO:0007004)	3.64692598
42	negative regulation of alcohol biosynthetic process (GO:1902931)	3.62812700
43	maturation of 5.8S rRNA (GO:0000460)	3.57166243
44	positive regulation of translational initiation (GO:0045948)	3.56496089
45	protein K6-linked ubiquitination (GO:0085020)	3.55272101
46	regulation of lipoprotein particle clearance (GO:0010984)	3.49834925
47	regulation of telomerase activity (GO:0051972)	3.41117577
48	regulation of feeding behavior (GO:0060259)	3.38753121
49	lens fiber cell development (GO:0070307)	3.31949470
50	folic acid-containing compound metabolic process (GO:0006760)	3.28942988
51	synapsis (GO:0007129)	3.27954566
52	folic acid metabolic process (GO:0046655)	3.26348896
53	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.25484976
54	regulation of T-helper 1 type immune response (GO:0002825)	3.25280418
55	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.24457944
56	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.21245281
57	ribosomal small subunit assembly (GO:0000028)	3.19240705
58	ATP biosynthetic process (GO:0006754)	3.18124227
59	oxygen transport (GO:0015671)	3.10134443
60	meiosis I (GO:0007127)	3.09503064
61	digestive tract morphogenesis (GO:0048546)	3.09324055
62	neuron remodeling (GO:0016322)	3.08340471
63	positive regulation of vesicle fusion (GO:0031340)	3.02841956
64	autophagic vacuole fusion (GO:0000046)	3.01949400
65	translational elongation (GO:0006414)	3.01133306
66	keratan sulfate biosynthetic process (GO:0018146)	2.98671131
67	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.97251830
68	negative regulation of DNA biosynthetic process (GO:2000279)	2.96811646
69	notochord development (GO:0030903)	2.96434982
70	protein deneddylation (GO:0000338)	2.95132082
71	ribosomal small subunit biogenesis (GO:0042274)	2.94357701
72	cotranslational protein targeting to membrane (GO:0006613)	2.92670191
73	protein targeting to ER (GO:0045047)	2.90659583
74	tetrahydrofolate metabolic process (GO:0046653)	2.90610613
75	fusion of sperm to egg plasma membrane (GO:0007342)	2.89913700
76	organelle membrane fusion (GO:0090174)	2.89619287
77	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.88404954
78	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.86450215
79	cytidine deamination (GO:0009972)	2.77780433
80	cytidine metabolic process (GO:0046087)	2.77780433
81	cytidine catabolic process (GO:0006216)	2.77780433
82	multicellular organism reproduction (GO:0032504)	2.75995373
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75719341
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75719341
85	NADH dehydrogenase complex assembly (GO:0010257)	2.75719341
86	lateral sprouting from an epithelium (GO:0060601)	2.75393053
87	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.74601329
88	protein localization to endoplasmic reticulum (GO:0070972)	2.74258421
89	middle ear morphogenesis (GO:0042474)	2.72828020
90	establishment of nucleus localization (GO:0040023)	2.71021772
91	response to dietary excess (GO:0002021)	2.68191306
92	cellular protein complex disassembly (GO:0043624)	2.65399571
93	regulation of isotype switching (GO:0045191)	2.64451954
94	pteridine-containing compound metabolic process (GO:0042558)	2.64166288
95	prostate gland growth (GO:0060736)	2.61613472
96	electron transport chain (GO:0022900)	2.61566169
97	positive regulation of fatty acid transport (GO:2000193)	2.61151121
98	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.57464736
99	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.56675692
100	regulation of centriole replication (GO:0046599)	2.56266225

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.17523005
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46516789
3	VDR_22108803_ChIP-Seq_LS180_Human	3.11291798
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.94221127
5	ZNF263_19887448_ChIP-Seq_K562_Human	2.93248369
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.57050071
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46181774
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.31081508
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30179108
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.23962847
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23546854
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22121594
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.15793922
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.13677957
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12677636
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96772869
17	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.91641006
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90008755
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.75935047
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75193762
21	AR_20517297_ChIP-Seq_VCAP_Human	1.73780758
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.69230541
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64796047
24	EWS_26573619_Chip-Seq_HEK293_Human	1.63116184
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.61848933
26	TAF2_19829295_ChIP-Seq_ESCs_Human	1.61688420
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60427138
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60074974
29	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.58980518
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58643778
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55011177
32	GATA1_22025678_ChIP-Seq_K562_Human	1.54136010
33	GATA3_26560356_Chip-Seq_TH2_Human	1.51853761
34	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.51320676
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.50194313
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46937607
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46370087
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46334437
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43636300
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42463791
41	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41353649
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41297616
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38259041
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38086963
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.34409949
46	ERA_21632823_ChIP-Seq_H3396_Human	1.33093267
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30287468
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27424229
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26629524
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26629524
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24242312
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.23408590
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23341493
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.23254689
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21299425
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21299425
57	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18066387
58	FUS_26573619_Chip-Seq_HEK293_Human	1.17317170
59	P300_19829295_ChIP-Seq_ESCs_Human	1.15578488
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15129819
61	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.14948255
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13944014
63	EGR1_19032775_ChIP-ChIP_M12_Human	1.12064882
64	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.11901841
65	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.11436174
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.09023309
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08429533
68	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.08284210
69	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07117684
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07065797
71	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07036818
72	NCOR_22424771_ChIP-Seq_293T_Human	1.06354085
73	PHF8_20622853_ChIP-Seq_HELA_Human	1.04568489
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03090503
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.02371828
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02195631
77	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.01997326
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01627032
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01591667
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01520618
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.01465452
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.00680986
83	BCAT_22108803_ChIP-Seq_LS180_Human	1.00371247
84	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00264370
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00223293
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99801799
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99528830
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99524544
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99259864
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97690496
91	P300_27268052_Chip-Seq_Bcells_Human	0.96765340
92	GATA3_26560356_Chip-Seq_TH1_Human	0.95541909
93	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.94926252
94	TCF4_23295773_ChIP-Seq_U87_Human	0.93396875
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93275138
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92995297
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92937494
98	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91946100
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91735012
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.91427375

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	7.07884445
2	MP0004782_abnormal_surfactant_physiolog	4.69713263
3	MP0004885_abnormal_endolymph	3.84942221
4	MP0002653_abnormal_ependyma_morphology	3.08379006
5	MP0003136_yellow_coat_color	3.06968995
6	MP0003011_delayed_dark_adaptation	2.85483433
7	MP0001873_stomach_inflammation	2.78858906
8	MP0001177_atelectasis	2.67744200
9	MP0008875_abnormal_xenobiotic_pharmacok	2.27014334
10	MP0004142_abnormal_muscle_tone	2.25933185
11	MP0000462_abnormal_digestive_system	2.10234957
12	MP0000372_irregular_coat_pigmentation	2.06465727
13	MP0000579_abnormal_nail_morphology	1.97577357
14	MP0002332_abnormal_exercise_endurance	1.97403799
15	MP0005671_abnormal_response_to	1.89294473
16	MP0001440_abnormal_grooming_behavior	1.79427479
17	MP0000383_abnormal_hair_follicle	1.78801373
18	MP0010030_abnormal_orbit_morphology	1.78396697
19	MP0002295_abnormal_pulmonary_circulatio	1.78279724
20	MP0004043_abnormal_pH_regulation	1.67043395
21	MP0003137_abnormal_impulse_conducting	1.59738117
22	MP0003890_abnormal_embryonic-extraembry	1.58715977
23	MP0002006_tumorigenesis	1.55575428
24	MP0000537_abnormal_urethra_morphology	1.53883698
25	MP0005551_abnormal_eye_electrophysiolog	1.52768804
26	MP0001293_anophthalmia	1.51527936
27	MP0002166_altered_tumor_susceptibility	1.51138196
28	MP0003195_calcinosis	1.48458206
29	MP0004145_abnormal_muscle_electrophysio	1.47615102
30	MP0008877_abnormal_DNA_methylation	1.40420233
31	MP0005381_digestive/alimentary_phenotyp	1.39469277
32	MP0000631_abnormal_neuroendocrine_gland	1.34128821
33	MP0001346_abnormal_lacrimal_gland	1.33255569
34	MP0000427_abnormal_hair_cycle	1.28523360
35	MP0005085_abnormal_gallbladder_physiolo	1.27148439
36	MP0005670_abnormal_white_adipose	1.27004725
37	MP0001986_abnormal_taste_sensitivity	1.26913556
38	MP0002095_abnormal_skin_pigmentation	1.25024619
39	MP0002282_abnormal_trachea_morphology	1.24255342
40	MP0002277_abnormal_respiratory_mucosa	1.23769409
41	MP0002133_abnormal_respiratory_system	1.22496487
42	MP0005388_respiratory_system_phenotype	1.22496487
43	MP0002163_abnormal_gland_morphology	1.22486081
44	MP0002938_white_spotting	1.18350740
45	MP0010678_abnormal_skin_adnexa	1.17505476
46	MP0001851_eye_inflammation	1.17040615
47	MP0009764_decreased_sensitivity_to	1.15989566
48	MP0000470_abnormal_stomach_morphology	1.15466861
49	MP0002736_abnormal_nociception_after	1.12059561
50	MP0008872_abnormal_physiological_respon	1.11721641
51	MP0001835_abnormal_antigen_presentation	1.11654677
52	MP0000685_abnormal_immune_system	1.08869310
53	MP0005379_endocrine/exocrine_gland_phen	1.06050183
54	MP0001666_abnormal_nutrient_absorption	1.03600368
55	MP0004147_increased_porphyrin_level	1.02371020
56	MP0001984_abnormal_olfaction	1.00680699
57	MP0002249_abnormal_larynx_morphology	0.97744632
58	MP0001663_abnormal_digestive_system	0.97082406
59	MP0001968_abnormal_touch/_nociception	0.94147294
60	MP0002148_abnormal_hypersensitivity_rea	0.89943400
61	MP0006292_abnormal_olfactory_placode	0.85029712
62	MP0003693_abnormal_embryo_hatching	0.82502173
63	MP0002234_abnormal_pharynx_morphology	0.81129251
64	MP0001800_abnormal_humoral_immune	0.79231908
65	MP0005360_urolithiasis	0.77440922
66	MP0001944_abnormal_pancreas_morphology	0.76836748
67	MP0002233_abnormal_nose_morphology	0.75591174
68	MP0002139_abnormal_hepatobiliary_system	0.75189847
69	MP0005365_abnormal_bile_salt	0.74866585
70	MP0009785_altered_susceptibility_to	0.74721231
71	MP0005075_abnormal_melanosome_morpholog	0.72021420
72	MP0002693_abnormal_pancreas_physiology	0.69332401
73	MP0003646_muscle_fatigue	0.69329164
74	MP0001299_abnormal_eye_distance/	0.69284887
75	MP0000538_abnormal_urinary_bladder	0.68433481
76	MP0002102_abnormal_ear_morphology	0.68183634
77	MP0005389_reproductive_system_phenotype	0.67767265
78	MP0002837_dystrophic_cardiac_calcinosis	0.67677971
79	MP0001790_abnormal_immune_system	0.67361675
80	MP0005387_immune_system_phenotype	0.67361675
81	MP0009379_abnormal_foot_pigmentation	0.67256487
82	MP0002009_preneoplasia	0.66594742
83	MP0001905_abnormal_dopamine_level	0.64963205
84	MP0005253_abnormal_eye_physiology	0.62794588
85	MP0003937_abnormal_limbs/digits/tail_de	0.62774570
86	MP0001502_abnormal_circadian_rhythm	0.62091638
87	MP0002638_abnormal_pupillary_reflex	0.61304263
88	MP0005645_abnormal_hypothalamus_physiol	0.61032970
89	MP0005646_abnormal_pituitary_gland	0.60513779
90	MP0006036_abnormal_mitochondrial_physio	0.59757429
91	MP0002160_abnormal_reproductive_system	0.59245027
92	MP0009333_abnormal_splenocyte_physiolog	0.58743759
93	MP0000049_abnormal_middle_ear	0.58703866
94	MP0008873_increased_physiological_sensi	0.57710553
95	MP0009765_abnormal_xenobiotic_induced	0.57144335
96	MP0006072_abnormal_retinal_apoptosis	0.56755176
97	MP0002723_abnormal_immune_serum	0.55243800
98	MP0003806_abnormal_nucleotide_metabolis	0.55193476
99	MP0003755_abnormal_palate_morphology	0.55185208
100	MP0005000_abnormal_immune_tolerance	0.54121342

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	4.48929467
2	Abnormality of the phalanges of the 2nd finger (HP:0009541)	4.34186138
3	Abnormality of the middle phalanges of the toes (HP:0010183)	4.23412242
4	Conical tooth (HP:0000698)	4.04287755
5	Partial duplication of thumb phalanx (HP:0009944)	3.86259117
6	Megalencephaly (HP:0001355)	3.53538313
7	Stenosis of the external auditory canal (HP:0000402)	3.51195218
8	Chronic otitis media (HP:0000389)	3.47571345
9	Stomach cancer (HP:0012126)	3.46145940
10	Aplasia involving bones of the extremities (HP:0009825)	3.45176975
11	Aplasia involving bones of the upper limbs (HP:0009823)	3.45176975
12	Aplasia of the phalanges of the hand (HP:0009802)	3.45176975
13	Synostosis involving the elbow (HP:0003938)	3.33724495
14	Humeroradial synostosis (HP:0003041)	3.33724495
15	Partial duplication of the phalanx of hand (HP:0009999)	3.32817540
16	Chronic hepatic failure (HP:0100626)	3.30295035
17	Methylmalonic acidemia (HP:0002912)	3.21256507
18	Esophageal atresia (HP:0002032)	3.15959990
19	Abnormality of the 2nd finger (HP:0004100)	2.97764472
20	Abnormality of the labia minora (HP:0012880)	2.96777615
21	Stomatitis (HP:0010280)	2.94683868
22	Short phalanx of the thumb (HP:0009660)	2.84714885
23	Abnormality of incisor morphology (HP:0011063)	2.79307114
24	Cheilitis (HP:0100825)	2.73214601
25	Large for gestational age (HP:0001520)	2.72886553
26	Supernumerary bones of the axial skeleton (HP:0009144)	2.69264187
27	Thickened helices (HP:0000391)	2.68117181
28	Abnormality of the parietal bone (HP:0002696)	2.62196665
29	Lipid accumulation in hepatocytes (HP:0006561)	2.61208630
30	Hypoproteinemia (HP:0003075)	2.60313549
31	Abnormality of the renal cortex (HP:0011035)	2.59992589
32	Short 1st metacarpal (HP:0010034)	2.59542045
33	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.59542045
34	Supernumerary ribs (HP:0005815)	2.58992634
35	Abnormal hemoglobin (HP:0011902)	2.57232344
36	Gastrointestinal atresia (HP:0002589)	2.55681914
37	Recurrent corneal erosions (HP:0000495)	2.51131764
38	Increased hepatocellular lipid droplets (HP:0006565)	2.50541849
39	Nonprogressive disorder (HP:0003680)	2.49748872
40	Overriding aorta (HP:0002623)	2.46903887
41	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.43900919
42	Hypochromic anemia (HP:0001931)	2.42622597
43	Hypoplasia of the ulna (HP:0003022)	2.40957082
44	Coronal craniosynostosis (HP:0004440)	2.40815224
45	Megaloblastic anemia (HP:0001889)	2.40560985
46	Renal cortical cysts (HP:0000803)	2.39666937
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35390207
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35390207
49	Abnormality of the 1st metacarpal (HP:0010009)	2.31712041
50	Gonadal dysgenesis (HP:0000133)	2.30011014
51	Exertional dyspnea (HP:0002875)	2.28197218
52	Rib fusion (HP:0000902)	2.27414363
53	Bronchomalacia (HP:0002780)	2.25632842
54	Pallor (HP:0000980)	2.24676155
55	Macrocytic anemia (HP:0001972)	2.22296993
56	Xerostomia (HP:0000217)	2.21842949
57	True hermaphroditism (HP:0010459)	2.20512284
58	Alacrima (HP:0000522)	2.19290275
59	Short middle phalanx of finger (HP:0005819)	2.17930930
60	Poor head control (HP:0002421)	2.16756535
61	Split foot (HP:0001839)	2.15556745
62	Methylmalonic aciduria (HP:0012120)	2.15088524
63	Short hallux (HP:0010109)	2.14705106
64	Molar tooth sign on MRI (HP:0002419)	2.13943472
65	Abnormality of midbrain morphology (HP:0002418)	2.13943472
66	Nasolacrimal duct obstruction (HP:0000579)	2.12876290
67	Renal Fanconi syndrome (HP:0001994)	2.12718780
68	Congenital stationary night blindness (HP:0007642)	2.12468130
69	Bowed forearm bones (HP:0003956)	2.11048826
70	Bowing of the arm (HP:0006488)	2.11048826
71	Synostosis of carpal bones (HP:0005048)	2.09585748
72	Duplication of thumb phalanx (HP:0009942)	2.07286405
73	IgG deficiency (HP:0004315)	2.05799018
74	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.04437899
75	Acute necrotizing encephalopathy (HP:0006965)	1.99524019
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98009841
77	Absent/shortened dynein arms (HP:0200106)	1.98009841
78	Fused cervical vertebrae (HP:0002949)	1.97512836
79	Vertebral fusion (HP:0002948)	1.97122279
80	Neonatal short-limb short stature (HP:0008921)	1.94313372
81	Radial bowing (HP:0002986)	1.94018805
82	Acute encephalopathy (HP:0006846)	1.93362905
83	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.92687755
84	Pancreatic cysts (HP:0001737)	1.91871156
85	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.91776211
86	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91305289
87	Hypoplasia of the pons (HP:0012110)	1.89953274
88	Sleep apnea (HP:0010535)	1.89429588
89	2-3 toe syndactyly (HP:0004691)	1.88501937
90	Broad distal phalanx of finger (HP:0009836)	1.88332337
91	Hypoplasia of the radius (HP:0002984)	1.87731817
92	Oral leukoplakia (HP:0002745)	1.87694171
93	Bifid scrotum (HP:0000048)	1.86693717
94	Abnormality of the lacrimal duct (HP:0011481)	1.86001197
95	Decreased central vision (HP:0007663)	1.85344884
96	Hypoplastic labia majora (HP:0000059)	1.84341582
97	Abnormal number of erythroid precursors (HP:0012131)	1.83601562
98	Abnormality of the pons (HP:0007361)	1.83039539
99	Bell-shaped thorax (HP:0001591)	1.82625766
100	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82143807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR2	5.31566451
2	TLK1	5.09237458
3	TAOK3	4.39926546
4	PINK1	3.69241102
5	AKT3	2.71100439
6	ZAK	2.59986586
7	MAP2K6	2.46679703
8	FGFR1	2.32214698
9	TNK2	2.30014863
10	MST4	2.09557872
11	WNK4	2.09234844
12	ADRBK2	2.02766907
13	GRK1	1.83672318
14	PLK4	1.83126499
15	NUAK1	1.78358642
16	MAP4K2	1.64386226
17	STK39	1.48023039
18	DAPK2	1.45011656
19	FRK	1.41879655
20	LATS1	1.30336292
21	RPS6KA5	1.24690624
22	IKBKB	1.16323457
23	MUSK	1.15349339
24	BMPR2	1.15227104
25	IKBKE	1.13593174
26	NEK1	1.09919649
27	TAOK2	1.08728101
28	PIK3CA	1.06619463
29	PHKG2	1.05496561
30	PHKG1	1.05496561
31	WNK1	1.05300866
32	PIM1	0.97099873
33	SGK2	0.97071006
34	OXSR1	0.96479076
35	BUB1	0.92473089
36	PIK3CG	0.91483620
37	MAPKAPK5	0.91396219
38	JAK3	0.89005036
39	NME1	0.88719192
40	WNK3	0.88583991
41	INSRR	0.88352742
42	IRAK3	0.88008084
43	IRAK4	0.85939079
44	ADRBK1	0.80918941
45	NME2	0.79695634
46	RIPK4	0.78827904
47	TESK1	0.78717049
48	PAK3	0.77631376
49	SGK494	0.76893245
50	SGK223	0.76893245
51	MKNK1	0.76580949
52	CSNK1A1	0.75048218
53	STK38L	0.74480265
54	TSSK6	0.73303312
55	CDK8	0.68068880
56	CSNK1G3	0.66915693
57	BTK	0.64163242
58	TXK	0.62310331
59	TIE1	0.60487267
60	PRKACA	0.59330745
61	FGFR3	0.58858221
62	MAP2K3	0.56441317
63	PRKD2	0.54249408
64	CSNK1G1	0.53806840
65	STK3	0.53494654
66	GRK7	0.51727918
67	KIT	0.49691730
68	TGFBR2	0.49515835
69	CSNK1G2	0.48835666
70	STK4	0.47933878
71	TAF1	0.47814774
72	CAMK2A	0.47279114
73	RPS6KA6	0.46616559
74	PLK1	0.45494664
75	AURKA	0.45130815
76	OBSCN	0.42977586
77	CSNK2A2	0.42091677
78	TEC	0.40517797
79	ROCK1	0.39125173
80	BMPR1B	0.38353043
81	SYK	0.37913903
82	PBK	0.37741314
83	PRKCQ	0.37718821
84	LCK	0.37493382
85	NEK9	0.37456207
86	CSNK2A1	0.37196427
87	STK11	0.36732617
88	ITK	0.36513488
89	PRKCG	0.36068898
90	PKN1	0.34701486
91	PRKCA	0.34144069
92	VRK1	0.32690278
93	WEE1	0.31055948
94	PRPF4B	0.30608126
95	ERBB4	0.30033929
96	STK16	0.30025852
97	CSNK1D	0.29599904
98	PRKCE	0.29425649
99	BCKDK	0.28835538
100	AURKB	0.28606036

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	5.38191567
2	Ribosome_Homo sapiens_hsa03010	3.34703742
3	One carbon pool by folate_Homo sapiens_hsa00670	3.18690307
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.15259474
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.07902852
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.88916560
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.70798417
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.65244544
9	Folate biosynthesis_Homo sapiens_hsa00790	2.63057210
10	Phototransduction_Homo sapiens_hsa04744	2.57031043
11	Caffeine metabolism_Homo sapiens_hsa00232	2.55396245
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.42467706
13	Sulfur relay system_Homo sapiens_hsa04122	2.40977288
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.25162440
15	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.21337101
16	Allograft rejection_Homo sapiens_hsa05330	2.05757087
17	Asthma_Homo sapiens_hsa05310	2.05569148
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.90865745
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.83724118
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.74881572
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.73252531
22	Proteasome_Homo sapiens_hsa03050	1.71780016
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64750189
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.49496049
25	Parkinsons disease_Homo sapiens_hsa05012	1.47269315
26	Homologous recombination_Homo sapiens_hsa03440	1.39417987
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35734153
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.34825561
29	RNA polymerase_Homo sapiens_hsa03020	1.24958582
30	Mineral absorption_Homo sapiens_hsa04978	1.22611112
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.18899990
32	Protein export_Homo sapiens_hsa03060	1.12925065
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.12516728
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.10205359
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09470484
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06804743
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01072909
38	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96156674
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95849574
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94856043
41	Fat digestion and absorption_Homo sapiens_hsa04975	0.83729423
42	Huntingtons disease_Homo sapiens_hsa05016	0.82997252
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.82041369
44	Butanoate metabolism_Homo sapiens_hsa00650	0.80024491
45	Retinol metabolism_Homo sapiens_hsa00830	0.78165492
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77676187
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76929131
48	Alzheimers disease_Homo sapiens_hsa05010	0.76224739
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74822212
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74165190
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73443682
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.70463000
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.69829470
54	Peroxisome_Homo sapiens_hsa04146	0.69671866
55	Steroid biosynthesis_Homo sapiens_hsa00100	0.68417566
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62614909
57	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59670967
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58300567
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55520264
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53812148
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52189070
62	Basal transcription factors_Homo sapiens_hsa03022	0.51949103
63	Malaria_Homo sapiens_hsa05144	0.50500343
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49575598
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48997794
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47503286
67	Histidine metabolism_Homo sapiens_hsa00340	0.46538299
68	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.46268546
69	Metabolic pathways_Homo sapiens_hsa01100	0.45208404
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.45098852
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44953187
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44867995
73	Olfactory transduction_Homo sapiens_hsa04740	0.43909501
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43200115
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42548598
76	Measles_Homo sapiens_hsa05162	0.41909244
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41029513
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40675394
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.40582169
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.39871835
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.37503685
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37335446
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35228530
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33354481
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31575669
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.30233261
87	RNA transport_Homo sapiens_hsa03013	0.29061914
88	Circadian rhythm_Homo sapiens_hsa04710	0.28511524
89	ABC transporters_Homo sapiens_hsa02010	0.26679064
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26049811
91	RNA degradation_Homo sapiens_hsa03018	0.25741016
92	Nicotine addiction_Homo sapiens_hsa05033	0.25301741
93	Propanoate metabolism_Homo sapiens_hsa00640	0.24791158
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.23898166
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.23578869
96	Regulation of autophagy_Homo sapiens_hsa04140	0.22549025
97	Purine metabolism_Homo sapiens_hsa00230	0.21920756
98	Viral myocarditis_Homo sapiens_hsa05416	0.20772200
99	p53 signaling pathway_Homo sapiens_hsa04115	0.20537941
100	Pancreatic secretion_Homo sapiens_hsa04972	0.18470909

RPL23AP59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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