RPL23AP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.73613934
2regulation of immunoglobulin secretion (GO:0051023)5.48136237
3DNA deamination (GO:0045006)5.24382179
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.97979704
5regulation of regulatory T cell differentiation (GO:0045589)4.76617976
6regulation of isotype switching to IgG isotypes (GO:0048302)4.26903129
7interferon-gamma production (GO:0032609)4.20035391
8water-soluble vitamin biosynthetic process (GO:0042364)4.10674707
9regulation of memory T cell differentiation (GO:0043380)4.07638507
10positive regulation of defense response to virus by host (GO:0002230)3.76773745
11positive regulation of interleukin-17 production (GO:0032740)3.70141470
12positive regulation of T-helper 1 type immune response (GO:0002827)3.58324929
13positive regulation of isotype switching (GO:0045830)3.57998131
14regulation of cilium movement (GO:0003352)3.57387640
15somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.56506415
16isotype switching (GO:0045190)3.56506415
17somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.56506415
18mucosal-associated lymphoid tissue development (GO:0048537)3.53873671
19Peyers patch development (GO:0048541)3.53873671
20negative regulation of B cell apoptotic process (GO:0002903)3.52356258
21positive regulation of T cell cytokine production (GO:0002726)3.49490377
22GTP biosynthetic process (GO:0006183)3.46852025
23proteasome assembly (GO:0043248)3.45871157
24fucose catabolic process (GO:0019317)3.44384823
25L-fucose metabolic process (GO:0042354)3.44384823
26L-fucose catabolic process (GO:0042355)3.44384823
27positive regulation of T cell migration (GO:2000406)3.41110958
28positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39003789
29respiratory chain complex IV assembly (GO:0008535)3.37072421
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.36534941
31termination of RNA polymerase III transcription (GO:0006386)3.35174543
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.35174543
33positive regulation of DNA recombination (GO:0045911)3.34281667
34activated T cell proliferation (GO:0050798)3.33359275
35positive regulation of immunoglobulin mediated immune response (GO:0002891)3.29494850
36positive regulation of B cell mediated immunity (GO:0002714)3.29494850
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27397894
38mast cell activation (GO:0045576)3.26069636
39chaperone-mediated protein transport (GO:0072321)3.25989667
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.25793230
41rRNA catabolic process (GO:0016075)3.23625824
42protein-cofactor linkage (GO:0018065)3.21790375
43behavioral response to nicotine (GO:0035095)3.19494358
44positive regulation of immune response to tumor cell (GO:0002839)3.18368435
45regulation of immune response to tumor cell (GO:0002837)3.18368435
46regulation of response to tumor cell (GO:0002834)3.18368435
47positive regulation of response to tumor cell (GO:0002836)3.18368435
48regulation of T cell mediated cytotoxicity (GO:0001914)3.15700832
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14492322
50positive regulation of cell fate commitment (GO:0010455)3.12927110
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.10490324
52ribosome biogenesis (GO:0042254)3.09486724
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06435211
54positive regulation of natural killer cell mediated immunity (GO:0002717)3.04948275
55rRNA modification (GO:0000154)3.03001902
56ATP synthesis coupled proton transport (GO:0015986)3.00849083
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00849083
58regulation of T cell migration (GO:2000404)3.00621836
59positive regulation of activated T cell proliferation (GO:0042104)2.98870387
60metallo-sulfur cluster assembly (GO:0031163)2.98612644
61iron-sulfur cluster assembly (GO:0016226)2.98612644
62positive regulation of immunoglobulin production (GO:0002639)2.97815582
63peptidyl-histidine modification (GO:0018202)2.94127727
64UTP biosynthetic process (GO:0006228)2.93694423
65cytochrome complex assembly (GO:0017004)2.89855563
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87210688
67transcription from mitochondrial promoter (GO:0006390)2.84236841
68mitochondrial respiratory chain complex assembly (GO:0033108)2.82457081
69rRNA metabolic process (GO:0016072)2.82145548
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81841839
71cellular ketone body metabolic process (GO:0046950)2.80066937
72kynurenine metabolic process (GO:0070189)2.79644504
73positive regulation of lymphocyte mediated immunity (GO:0002708)2.78825143
74natural killer cell differentiation (GO:0001779)2.78486352
75adenosine metabolic process (GO:0046085)2.78318822
76auditory receptor cell stereocilium organization (GO:0060088)2.78190113
77ribosomal large subunit biogenesis (GO:0042273)2.77952191
78positive regulation of lymphocyte migration (GO:2000403)2.77917207
79natural killer cell activation (GO:0030101)2.77812144
80positive regulation of cell killing (GO:0031343)2.77146603
81rRNA processing (GO:0006364)2.76293032
82protein complex biogenesis (GO:0070271)2.74158315
83regulation of natural killer cell mediated immunity (GO:0002715)2.73731822
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73731822
85regulation of immunoglobulin production (GO:0002637)2.73298591
86mast cell activation involved in immune response (GO:0002279)2.73039166
87mast cell degranulation (GO:0043303)2.73039166
88regulation of T-helper 1 type immune response (GO:0002825)2.72475082
89cellular response to exogenous dsRNA (GO:0071360)2.67676902
90glycine transport (GO:0015816)2.67587326
91tolerance induction (GO:0002507)2.67058350
92negative regulation of heart rate (GO:0010459)2.65652513
93regulation of cell killing (GO:0031341)2.65649278
94somatic diversification of immunoglobulins (GO:0016445)2.65499517
95tryptophan catabolic process (GO:0006569)2.65456299
96indole-containing compound catabolic process (GO:0042436)2.65456299
97indolalkylamine catabolic process (GO:0046218)2.65456299
98termination of RNA polymerase I transcription (GO:0006363)2.62999506
99ribonucleoprotein complex biogenesis (GO:0022613)2.62759616
100multicellular organism reproduction (GO:0032504)2.61601179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98830615
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.69415406
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.68778195
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.49958744
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.22756454
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17347566
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84891582
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.84327338
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81178315
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71610890
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68615482
12ZNF274_21170338_ChIP-Seq_K562_Hela2.64318283
13VDR_23849224_ChIP-Seq_CD4+_Human2.64201579
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58032315
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52447751
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44709903
17VDR_22108803_ChIP-Seq_LS180_Human2.41649425
18FOXP3_21729870_ChIP-Seq_TREG_Human2.40810818
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.33928620
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27602580
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23915927
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.19895059
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.09230641
24ELK1_19687146_ChIP-ChIP_HELA_Human2.02773047
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91943940
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.85386121
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81493729
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.79986949
29DCP1A_22483619_ChIP-Seq_HELA_Human1.77154539
30GATA1_22025678_ChIP-Seq_K562_Human1.74159657
31GATA3_26560356_Chip-Seq_TH2_Human1.71754760
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65871390
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63126157
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61842984
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60688956
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.60015502
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59087909
38TP53_22573176_ChIP-Seq_HFKS_Human1.57354424
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53910771
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51714659
41IGF1R_20145208_ChIP-Seq_DFB_Human1.51397650
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48466614
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47866402
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47011876
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45003301
46MYC_18940864_ChIP-ChIP_HL60_Human1.42239706
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37896510
48EWS_26573619_Chip-Seq_HEK293_Human1.37666798
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36217153
50EZH2_22144423_ChIP-Seq_EOC_Human1.34427734
51TTF2_22483619_ChIP-Seq_HELA_Human1.34278403
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30726377
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30411593
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28896702
55GABP_19822575_ChIP-Seq_HepG2_Human1.28465524
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27328179
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26460759
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.26130942
59MYC_19829295_ChIP-Seq_ESCs_Human1.22195495
60MYB_26560356_Chip-Seq_TH2_Human1.22019804
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19269875
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.19087066
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18260399
64SOX2_19829295_ChIP-Seq_ESCs_Human1.12742799
65NANOG_19829295_ChIP-Seq_ESCs_Human1.12742799
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12154059
67GATA3_27048872_Chip-Seq_THYMUS_Human1.11511504
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10749144
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08842411
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.08788217
71RUNX_20019798_ChIP-Seq_JUKART_Human1.08347343
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07189986
73IRF1_19129219_ChIP-ChIP_H3396_Human1.06748619
74AR_20517297_ChIP-Seq_VCAP_Human1.04642771
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04410374
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04268852
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.04268852
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02546308
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.00939866
80E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99588542
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99537893
82ER_23166858_ChIP-Seq_MCF-7_Human0.99354290
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.98632995
84TAF2_19829295_ChIP-Seq_ESCs_Human0.96868651
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96007354
86ERA_21632823_ChIP-Seq_H3396_Human0.94901391
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93550149
88TAF15_26573619_Chip-Seq_HEK293_Human0.93332798
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92463048
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.91786371
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.89659499
92HOXB7_26014856_ChIP-Seq_BT474_Human0.88429130
93P53_21459846_ChIP-Seq_SAOS-2_Human0.88417762
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88116816
95ELF5_23300383_ChIP-Seq_T47D_Human0.86662831
96FUS_26573619_Chip-Seq_HEK293_Human0.85937352
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84453433
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83738632
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83055863
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82853200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.79023972
2MP0001835_abnormal_antigen_presentation3.81588730
3MP0001984_abnormal_olfaction3.28946543
4MP0003646_muscle_fatigue3.15860599
5MP0000685_abnormal_immune_system2.91357924
6MP0002163_abnormal_gland_morphology2.76075620
7MP0005671_abnormal_response_to2.73992715
8MP0002102_abnormal_ear_morphology2.67136440
9MP0001853_heart_inflammation2.62047051
10MP0003878_abnormal_ear_physiology2.60638623
11MP0005377_hearing/vestibular/ear_phenot2.60638623
12MP0001790_abnormal_immune_system2.46885749
13MP0005387_immune_system_phenotype2.46885749
14MP0003693_abnormal_embryo_hatching2.39838463
15MP0002736_abnormal_nociception_after2.30350158
16MP0006072_abnormal_retinal_apoptosis2.28721849
17MP0000604_amyloidosis2.28541039
18MP0000465_gastrointestinal_hemorrhage2.25039225
19MP0008877_abnormal_DNA_methylation2.08632085
20MP0001968_abnormal_touch/_nociception2.01953567
21MP0005075_abnormal_melanosome_morpholog2.01367535
22MP0002148_abnormal_hypersensitivity_rea1.79752571
23MP0005310_abnormal_salivary_gland1.73411866
24MP0001986_abnormal_taste_sensitivity1.70501461
25MP0004147_increased_porphyrin_level1.66416510
26MP0008872_abnormal_physiological_respon1.63676495
27MP0006036_abnormal_mitochondrial_physio1.62912017
28MP0003763_abnormal_thymus_physiology1.62245049
29MP0003300_gastrointestinal_ulcer1.62045453
30MP0005551_abnormal_eye_electrophysiolog1.61492855
31MP0001800_abnormal_humoral_immune1.53640898
32MP0005379_endocrine/exocrine_gland_phen1.50389769
33MP0008875_abnormal_xenobiotic_pharmacok1.47680830
34MP0004142_abnormal_muscle_tone1.38133527
35MP0008789_abnormal_olfactory_epithelium1.36241464
36MP0004381_abnormal_hair_follicle1.35937643
37MP0009780_abnormal_chondrocyte_physiolo1.35932004
38MP0001485_abnormal_pinna_reflex1.35254851
39MP0005000_abnormal_immune_tolerance1.32744134
40MP0004885_abnormal_endolymph1.32273589
41MP0003786_premature_aging1.31024642
42MP0002723_abnormal_immune_serum1.29386674
43MP0005645_abnormal_hypothalamus_physiol1.28106091
44MP0009333_abnormal_splenocyte_physiolog1.26963246
45MP0002420_abnormal_adaptive_immunity1.25766523
46MP0005670_abnormal_white_adipose1.25097370
47MP0001819_abnormal_immune_cell1.24325378
48MP0001529_abnormal_vocalization1.23120117
49MP0002006_tumorigenesis1.21881532
50MP0006035_abnormal_mitochondrial_morpho1.21772977
51MP0002272_abnormal_nervous_system1.19343426
52MP0000013_abnormal_adipose_tissue1.18323722
53MP0002452_abnormal_antigen_presenting1.12705690
54MP0006292_abnormal_olfactory_placode1.12462587
55MP0000703_abnormal_thymus_morphology1.11473765
56MP0005332_abnormal_amino_acid1.09364683
57MP0005389_reproductive_system_phenotype1.06052197
58MP0003195_calcinosis1.05840813
59MP0001881_abnormal_mammary_gland1.04624523
60MP0002398_abnormal_bone_marrow1.04574989
61MP0005253_abnormal_eye_physiology1.02921414
62MP0000689_abnormal_spleen_morphology0.99883781
63MP0002138_abnormal_hepatobiliary_system0.98606448
64MP0001905_abnormal_dopamine_level0.96304116
65MP0000716_abnormal_immune_system0.95894630
66MP0008058_abnormal_DNA_repair0.94975432
67MP0005410_abnormal_fertilization0.94903012
68MP0001486_abnormal_startle_reflex0.94761113
69MP0002160_abnormal_reproductive_system0.93373570
70MP0001502_abnormal_circadian_rhythm0.92934351
71MP0002722_abnormal_immune_system0.92034836
72MP0005025_abnormal_response_to0.90260840
73MP0001501_abnormal_sleep_pattern0.89955692
74MP0004215_abnormal_myocardial_fiber0.89872194
75MP0000372_irregular_coat_pigmentation0.89387526
76MP0005085_abnormal_gallbladder_physiolo0.89208496
77MP0004043_abnormal_pH_regulation0.85707987
78MP0009785_altered_susceptibility_to0.84684226
79MP0000538_abnormal_urinary_bladder0.84526588
80MP0001440_abnormal_grooming_behavior0.80253414
81MP0001919_abnormal_reproductive_system0.79658334
82MP0002429_abnormal_blood_cell0.79146616
83MP0001845_abnormal_inflammatory_respons0.78625615
84MP0005647_abnormal_sex_gland0.77382501
85MP0009764_decreased_sensitivity_to0.76352790
86MP0005174_abnormal_tail_pigmentation0.74695378
87MP0000569_abnormal_digit_pigmentation0.73869745
88MP0002405_respiratory_system_inflammati0.73641071
89MP0010094_abnormal_chromosome_stability0.73261974
90MP0008057_abnormal_DNA_replication0.73253550
91MP0002693_abnormal_pancreas_physiology0.72512011
92MP0003329_amyloid_beta_deposits0.72319469
93MP0000358_abnormal_cell_content/0.71046811
94MP0003011_delayed_dark_adaptation0.70818281
95MP0001873_stomach_inflammation0.69120460
96MP0009745_abnormal_behavioral_response0.68794783
97MP0002229_neurodegeneration0.68791527
98MP0000427_abnormal_hair_cycle0.68195232
99MP0005636_abnormal_mineral_homeostasis0.65124887
100MP0001963_abnormal_hearing_physiology0.64601090

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.26084455
2IgG deficiency (HP:0004315)4.72849255
3Increased IgM level (HP:0003496)3.65565356
4Abnormality of T cell physiology (HP:0011840)3.55456818
5Abnormality of B cell number (HP:0010975)3.49499650
6B lymphocytopenia (HP:0010976)3.47828287
7Congenital, generalized hypertrichosis (HP:0004540)3.43732421
8Papilledema (HP:0001085)3.39928600
9Congenital stationary night blindness (HP:0007642)3.38647933
10Type 2 muscle fiber atrophy (HP:0003554)3.29708114
11Type II lissencephaly (HP:0007260)3.11129666
12Abnormality of the renal cortex (HP:0011035)3.10014032
13Mitochondrial inheritance (HP:0001427)3.01846734
14Lipid accumulation in hepatocytes (HP:0006561)2.92552486
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92181284
16Abnormal rod and cone electroretinograms (HP:0008323)2.91439860
17Oligodactyly (hands) (HP:0001180)2.91125961
18Renal cortical cysts (HP:0000803)2.90302744
19Neutropenia (HP:0001875)2.90192872
20IgA deficiency (HP:0002720)2.89580280
21Acute necrotizing encephalopathy (HP:0006965)2.89411253
22Aplastic anemia (HP:0001915)2.88170693
23Hepatocellular necrosis (HP:0001404)2.87464226
24Acute encephalopathy (HP:0006846)2.85717562
253-Methylglutaconic aciduria (HP:0003535)2.85485647
26Muscle fiber atrophy (HP:0100295)2.84873834
27Pancytopenia (HP:0001876)2.83916783
28Retrobulbar optic neuritis (HP:0100654)2.79184710
29Optic neuritis (HP:0100653)2.79184710
30Increased CSF lactate (HP:0002490)2.77880056
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76452304
32Abnormality of T cells (HP:0002843)2.73669507
33IgM deficiency (HP:0002850)2.69824645
34Hepatic necrosis (HP:0002605)2.68769209
35Increased hepatocellular lipid droplets (HP:0006565)2.67445752
36Methylmalonic acidemia (HP:0002912)2.61118711
37Hyperglycinemia (HP:0002154)2.55543684
38Progressive macrocephaly (HP:0004481)2.50742925
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49641209
40Oligodactyly (HP:0012165)2.47193019
41Methylmalonic aciduria (HP:0012120)2.45337389
42Exertional dyspnea (HP:0002875)2.44585596
43Abnormality of the labia minora (HP:0012880)2.41470854
44Abnormality of midbrain morphology (HP:0002418)2.40765491
45Molar tooth sign on MRI (HP:0002419)2.40765491
46Asplenia (HP:0001746)2.39297119
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38888545
48Abnormality of alanine metabolism (HP:0010916)2.38888545
49Hyperalaninemia (HP:0003348)2.38888545
50Pancreatic cysts (HP:0001737)2.35567153
51Abnormal mitochondria in muscle tissue (HP:0008316)2.35200806
52Severe combined immunodeficiency (HP:0004430)2.33673015
53Optic disc pallor (HP:0000543)2.32593571
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.28222136
55Hypoplasia of the radius (HP:0002984)2.20793104
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.18009510
57Hypoplasia of the fovea (HP:0007750)2.18009510
58Testicular atrophy (HP:0000029)2.17552211
59Increased muscle lipid content (HP:0009058)2.14319552
60Increased serum lactate (HP:0002151)2.11085231
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11047080
62Conical tooth (HP:0000698)2.10679085
63Increased intramyocellular lipid droplets (HP:0012240)2.10658101
64Pigmentary retinal degeneration (HP:0001146)2.09978627
65Myositis (HP:0100614)2.09308085
66Keratoconjunctivitis (HP:0001096)2.07682886
67Hypoproteinemia (HP:0003075)2.06960339
68Panhypogammaglobulinemia (HP:0003139)2.05389063
69Dry hair (HP:0011359)2.05087156
70Abnormality of serine family amino acid metabolism (HP:0010894)2.04135221
71Abnormality of glycine metabolism (HP:0010895)2.04135221
72Orchitis (HP:0100796)2.02936234
73Thyroiditis (HP:0100646)2.02586106
74Abolished electroretinogram (ERG) (HP:0000550)2.01300838
75Abnormality of eosinophils (HP:0001879)1.97845221
76Cerebral edema (HP:0002181)1.97515762
77Sensory axonal neuropathy (HP:0003390)1.97163476
78Mesangial abnormality (HP:0001966)1.96030902
79Nephronophthisis (HP:0000090)1.94792520
80Keratoconjunctivitis sicca (HP:0001097)1.93846401
81Bile duct proliferation (HP:0001408)1.92929427
82Abnormal biliary tract physiology (HP:0012439)1.92929427
83Polydipsia (HP:0001959)1.92688004
84Abnormal drinking behavior (HP:0030082)1.92688004
85Elevated erythrocyte sedimentation rate (HP:0003565)1.92520460
86Duplicated collecting system (HP:0000081)1.91000614
87Encephalitis (HP:0002383)1.89726046
88Cerebellar dysplasia (HP:0007033)1.88154933
89Pendular nystagmus (HP:0012043)1.87711352
90Ureteral duplication (HP:0000073)1.85522339
91Abnormal protein N-linked glycosylation (HP:0012347)1.85078801
92Abnormal protein glycosylation (HP:0012346)1.85078801
93Abnormal glycosylation (HP:0012345)1.85078801
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85078801
95Cleft eyelid (HP:0000625)1.83324414
96Lactic acidosis (HP:0003128)1.81048691
97Abnormality of the fovea (HP:0000493)1.80303876
98Tubular atrophy (HP:0000092)1.80124390
99Forearm undergrowth (HP:0009821)1.79869345
100Abnormality of the pons (HP:0007361)1.79260868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23651490
2TAOK35.89373309
3MAP4K12.84936284
4MAP4K22.82338137
5ZAK2.60986161
6ADRBK22.58058007
7SRPK12.50384839
8BMPR22.46090481
9TSSK62.16476278
10FRK2.14641331
11GRK11.99897520
12MST41.97978162
13WNK41.96523403
14STK391.75218713
15MAP2K61.71337822
16EIF2AK11.69204958
17TLK11.65526702
18CAMKK21.62952378
19MAP3K111.49915708
20TEC1.48058050
21NEK11.46069235
22PASK1.41182621
23WNK31.34871634
24NEK91.31487480
25SCYL21.23168741
26VRK21.22585349
27TAOK21.21467409
28PLK31.15302705
29JAK31.12651836
30BCKDK1.12526533
31PIK3CG1.11648511
32NUAK11.07678133
33CAMKK11.03801030
34OXSR11.03444431
35FES1.02718522
36ITK1.01115631
37PHKG10.95011814
38PHKG20.95011814
39KIT0.94570393
40MARK30.93790212
41CSNK1A1L0.91895892
42PLK20.91844258
43GRK60.91531275
44MKNK20.89057295
45BUB10.85346091
46IKBKB0.80713256
47CSNK1G30.76847179
48SYK0.76747787
49ZAP700.76532294
50TAF10.73286563
51MATK0.71142549
52TTK0.69142316
53MAP3K90.67895017
54MAPKAPK30.66682298
55VRK10.64388580
56PLK40.63131657
57NME20.60965668
58PLK10.60373786
59TYRO30.59748366
60BMPR1B0.59414485
61MAP3K120.58820522
62LCK0.58019755
63PDK20.57514425
64GRK70.57203118
65CSNK1G20.56436050
66IKBKE0.55659691
67MAPK130.55450720
68MAPK110.54594880
69CSNK1G10.51845999
70ATR0.51391505
71CSK0.50802906
72ALK0.50225705
73BTK0.49089920
74ADRBK10.49074356
75NLK0.47527682
76LYN0.47224955
77EIF2AK20.45607295
78BRD40.44795285
79PINK10.43942947
80FGR0.43470462
81MKNK10.43131571
82INSRR0.42450971
83IGF1R0.40732735
84PRKCQ0.40244781
85PRKD20.40113449
86IRAK40.37895072
87CHEK20.37479695
88CSNK2A10.36477880
89PRKCH0.35431846
90RPS6KA50.34776265
91PAK30.34128915
92GRK50.33033598
93CSNK2A20.32912798
94MAP3K30.32562740
95STK100.30487420
96ERBB30.30337208
97EIF2AK30.29453539
98NME10.26237743
99AURKB0.25138494
100DAPK10.24543745

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.67638388
2Proteasome_Homo sapiens_hsa030503.59529946
3RNA polymerase_Homo sapiens_hsa030203.24145962
4Graft-versus-host disease_Homo sapiens_hsa053322.99168604
5Allograft rejection_Homo sapiens_hsa053302.92862229
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.83592062
7Autoimmune thyroid disease_Homo sapiens_hsa053202.73953842
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69654042
9Asthma_Homo sapiens_hsa053102.66487464
10Ribosome_Homo sapiens_hsa030102.64583590
11Basal transcription factors_Homo sapiens_hsa030222.53417197
12One carbon pool by folate_Homo sapiens_hsa006702.31591748
13Oxidative phosphorylation_Homo sapiens_hsa001902.19681309
14Type I diabetes mellitus_Homo sapiens_hsa049402.01957067
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79780635
16Vitamin B6 metabolism_Homo sapiens_hsa007501.76684850
17Parkinsons disease_Homo sapiens_hsa050121.69802227
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66488169
19Nucleotide excision repair_Homo sapiens_hsa034201.60797682
20Pyrimidine metabolism_Homo sapiens_hsa002401.60120706
21Homologous recombination_Homo sapiens_hsa034401.59459355
22Antigen processing and presentation_Homo sapiens_hsa046121.51706520
23Linoleic acid metabolism_Homo sapiens_hsa005911.49044080
24Protein export_Homo sapiens_hsa030601.45912337
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.43935438
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42477773
27Base excision repair_Homo sapiens_hsa034101.42193041
28RNA degradation_Homo sapiens_hsa030181.42136389
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41210417
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40257369
31T cell receptor signaling pathway_Homo sapiens_hsa046601.37963755
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35851107
33Mismatch repair_Homo sapiens_hsa034301.35738005
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22569547
35Non-homologous end-joining_Homo sapiens_hsa034501.20757030
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13772099
37Purine metabolism_Homo sapiens_hsa002301.08067084
38Huntingtons disease_Homo sapiens_hsa050161.05200445
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03540498
40DNA replication_Homo sapiens_hsa030301.02070873
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02065789
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01624808
43Fatty acid elongation_Homo sapiens_hsa000621.01268512
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.00967585
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00778515
46Phototransduction_Homo sapiens_hsa047441.00454487
47Hematopoietic cell lineage_Homo sapiens_hsa046400.99423838
48Regulation of autophagy_Homo sapiens_hsa041400.97863850
49Rheumatoid arthritis_Homo sapiens_hsa053230.97331890
50Tryptophan metabolism_Homo sapiens_hsa003800.96870956
51Alzheimers disease_Homo sapiens_hsa050100.96642158
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95956793
53Caffeine metabolism_Homo sapiens_hsa002320.92493562
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.90290200
55Spliceosome_Homo sapiens_hsa030400.88996328
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86727044
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76746817
58Fanconi anemia pathway_Homo sapiens_hsa034600.76491691
59Arachidonic acid metabolism_Homo sapiens_hsa005900.75049552
60Ether lipid metabolism_Homo sapiens_hsa005650.71651351
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68544550
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66768603
63Viral myocarditis_Homo sapiens_hsa054160.62569311
64Nitrogen metabolism_Homo sapiens_hsa009100.61890569
65Selenocompound metabolism_Homo sapiens_hsa004500.61195677
66RNA transport_Homo sapiens_hsa030130.59926032
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58742321
68Chemical carcinogenesis_Homo sapiens_hsa052040.57525948
69Malaria_Homo sapiens_hsa051440.56965518
70Propanoate metabolism_Homo sapiens_hsa006400.55601895
71Nicotine addiction_Homo sapiens_hsa050330.55029969
72Epstein-Barr virus infection_Homo sapiens_hsa051690.54793362
73Peroxisome_Homo sapiens_hsa041460.54345090
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54024445
75Butanoate metabolism_Homo sapiens_hsa006500.51848274
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.51025099
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.49593751
78Metabolic pathways_Homo sapiens_hsa011000.49543109
79Cardiac muscle contraction_Homo sapiens_hsa042600.48608745
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48089821
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47495035
82Collecting duct acid secretion_Homo sapiens_hsa049660.45261295
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.45172404
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.45016808
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44474118
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43243512
87TNF signaling pathway_Homo sapiens_hsa046680.40067092
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28858592
89Sulfur metabolism_Homo sapiens_hsa009200.28320782
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27733450
91Fatty acid metabolism_Homo sapiens_hsa012120.26575967
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26376305
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25059497
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23698187
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.20944610
96Fat digestion and absorption_Homo sapiens_hsa049750.18895643
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17090490
98HTLV-I infection_Homo sapiens_hsa051660.14707901
99Measles_Homo sapiens_hsa051620.14061334
100Mineral absorption_Homo sapiens_hsa049780.14044139

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