RPL23AP61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.80554852
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.47908334
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45612648
4ATP synthesis coupled proton transport (GO:0015986)5.45612648
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.43021948
6ribosomal small subunit assembly (GO:0000028)4.71603697
7protein complex biogenesis (GO:0070271)4.44949824
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44212784
9viral transcription (GO:0019083)4.43303790
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.27184139
11NADH dehydrogenase complex assembly (GO:0010257)4.27184139
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27184139
13translational termination (GO:0006415)4.23898108
14positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.12477189
15proteasome assembly (GO:0043248)4.09433732
16maturation of SSU-rRNA (GO:0030490)4.09021914
17mitochondrial respiratory chain complex assembly (GO:0033108)4.08762257
18electron transport chain (GO:0022900)4.06818402
19respiratory electron transport chain (GO:0022904)4.04789452
20ribosomal small subunit biogenesis (GO:0042274)3.95631005
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.89568975
22chaperone-mediated protein transport (GO:0072321)3.89306943
23cotranslational protein targeting to membrane (GO:0006613)3.84513821
24respiratory chain complex IV assembly (GO:0008535)3.83693722
25protein targeting to ER (GO:0045047)3.82540356
26regulation of isotype switching to IgG isotypes (GO:0048302)3.80752723
27protein neddylation (GO:0045116)3.72561737
28regulation of immunoglobulin secretion (GO:0051023)3.69763651
29translational elongation (GO:0006414)3.69482119
30regulation of regulatory T cell differentiation (GO:0045589)3.66997263
31water-soluble vitamin biosynthetic process (GO:0042364)3.66987861
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64133342
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63014324
34rRNA modification (GO:0000154)3.61069002
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59400295
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59219443
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59219443
38protein localization to endoplasmic reticulum (GO:0070972)3.58536914
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54313234
40regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.49051735
41cytochrome complex assembly (GO:0017004)3.48574428
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.45245526
43termination of RNA polymerase III transcription (GO:0006386)3.45245526
44behavioral response to nicotine (GO:0035095)3.41142176
45translation (GO:0006412)3.40701365
46cytidine deamination (GO:0009972)3.35970431
47cytidine metabolic process (GO:0046087)3.35970431
48cytidine catabolic process (GO:0006216)3.35970431
49piRNA metabolic process (GO:0034587)3.34291193
50regulation of mitochondrial translation (GO:0070129)3.31671175
51ribosomal large subunit biogenesis (GO:0042273)3.27139919
52positive regulation of defense response to virus by host (GO:0002230)3.25302450
53pseudouridine synthesis (GO:0001522)3.24439610
54ATP biosynthetic process (GO:0006754)3.24032890
55viral life cycle (GO:0019058)3.19576470
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17222506
57regulation of cellular amino acid metabolic process (GO:0006521)3.15391140
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15079858
59hydrogen ion transmembrane transport (GO:1902600)3.14088261
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12766601
61translational initiation (GO:0006413)3.12036538
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07997399
63cellular protein complex disassembly (GO:0043624)3.03548756
64cellular component biogenesis (GO:0044085)3.01816254
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99553658
66positive regulation of protein homodimerization activity (GO:0090073)2.99467556
67cellular response to exogenous dsRNA (GO:0071360)2.93940769
68activated T cell proliferation (GO:0050798)2.93642688
69peptidyl-histidine modification (GO:0018202)2.92957291
70rRNA processing (GO:0006364)2.91787919
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89267756
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89267756
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89267756
74rRNA metabolic process (GO:0016072)2.88654479
75protein-cofactor linkage (GO:0018065)2.88338979
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87623052
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87623052
78GTP biosynthetic process (GO:0006183)2.86728590
79positive regulation of T cell migration (GO:2000406)2.86486473
80termination of RNA polymerase I transcription (GO:0006363)2.84779811
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83769967
82rRNA methylation (GO:0031167)2.83452798
83proton transport (GO:0015992)2.83134177
84response to pheromone (GO:0019236)2.80590318
85positive regulation of isotype switching (GO:0045830)2.80485737
86otic vesicle formation (GO:0030916)2.79452837
87positive regulation of DNA recombination (GO:0045911)2.77981715
88ribonucleoprotein complex biogenesis (GO:0022613)2.76738715
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75689638
90hydrogen transport (GO:0006818)2.75191756
91positive regulation of interleukin-17 production (GO:0032740)2.75078461
92negative regulation of ligase activity (GO:0051352)2.73871193
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73871193
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70992590
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.70992590
96establishment of protein localization to mitochondrion (GO:0072655)2.67787223
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.67237677
98protein targeting to mitochondrion (GO:0006626)2.66239425
99response to interferon-beta (GO:0035456)2.64563374
100inner mitochondrial membrane organization (GO:0007007)2.64279396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.53463053
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.35920803
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32319844
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.12012173
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.88844666
6VDR_22108803_ChIP-Seq_LS180_Human3.35935204
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01855181
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92529723
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90791454
10ZNF274_21170338_ChIP-Seq_K562_Hela2.77827030
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68859188
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.67477503
13VDR_23849224_ChIP-Seq_CD4+_Human2.57307349
14ELK1_19687146_ChIP-ChIP_HELA_Human2.35324589
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22305272
16FOXP3_21729870_ChIP-Seq_TREG_Human2.16210212
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.15849988
18EZH2_22144423_ChIP-Seq_EOC_Human2.08061371
19EWS_26573619_Chip-Seq_HEK293_Human1.93645962
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90313258
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.89689573
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85574047
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85571043
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.78539228
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70891131
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67178060
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.66663431
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.62761979
29MYC_18940864_ChIP-ChIP_HL60_Human1.61259760
30TP53_22573176_ChIP-Seq_HFKS_Human1.51842896
31IGF1R_20145208_ChIP-Seq_DFB_Human1.50813016
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50263311
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.47999211
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47614415
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.45562697
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44259040
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41857134
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.40767767
39GATA3_26560356_Chip-Seq_TH2_Human1.39318667
40AR_20517297_ChIP-Seq_VCAP_Human1.38009051
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37329225
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36159518
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35514261
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35288767
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31099300
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27820572
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27637839
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26448415
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26265585
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.26265585
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25384005
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24760397
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23794467
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21020853
55ER_23166858_ChIP-Seq_MCF-7_Human1.20818582
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18982379
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18530161
58TTF2_22483619_ChIP-Seq_HELA_Human1.15369539
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14958590
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13806706
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13337622
62IRF1_19129219_ChIP-ChIP_H3396_Human1.12717832
63FUS_26573619_Chip-Seq_HEK293_Human1.12644356
64P300_19829295_ChIP-Seq_ESCs_Human1.11449435
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09855959
66NANOG_19829295_ChIP-Seq_ESCs_Human1.09675350
67SOX2_19829295_ChIP-Seq_ESCs_Human1.09675350
68DCP1A_22483619_ChIP-Seq_HELA_Human1.09002494
69ERG_20517297_ChIP-Seq_VCAP_Human1.05838596
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.02578376
71XRN2_22483619_ChIP-Seq_HELA_Human1.01234653
72TAF2_19829295_ChIP-Seq_ESCs_Human1.01096285
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00124459
74CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99064771
75GATA6_21074721_ChIP-Seq_CACO-2_Human0.98775916
76IRF8_21731497_ChIP-ChIP_J774_Mouse0.97970907
77MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97833590
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97355369
79E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96410768
80GABP_19822575_ChIP-Seq_HepG2_Human0.95581852
81NCOR_22424771_ChIP-Seq_293T_Human0.95286694
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91421152
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90921979
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90843165
85CBP_20019798_ChIP-Seq_JUKART_Human0.90674289
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90674289
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.90337828
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90197668
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90085562
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.89844253
91GBX2_23144817_ChIP-Seq_PC3_Human0.89839434
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89626343
93PHF8_20622853_ChIP-Seq_HELA_Human0.89443184
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88729372
95HOXB7_26014856_ChIP-Seq_BT474_Human0.88662932
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88633319
97NANOG_20526341_ChIP-Seq_ESCs_Human0.87961433
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87741210
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85915066
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84977665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.43194904
2MP0001835_abnormal_antigen_presentation3.24209615
3MP0006292_abnormal_olfactory_placode2.91336743
4MP0008877_abnormal_DNA_methylation2.87134083
5MP0000372_irregular_coat_pigmentation2.80257888
6MP0002102_abnormal_ear_morphology2.63701642
7MP0000566_synostosis2.54280951
8MP0003136_yellow_coat_color2.30772448
9MP0004147_increased_porphyrin_level2.19872283
10MP0003646_muscle_fatigue2.16873584
11MP0002736_abnormal_nociception_after2.09973966
12MP0000685_abnormal_immune_system2.09662850
13MP0001968_abnormal_touch/_nociception2.09244124
14MP0003011_delayed_dark_adaptation2.06874371
15MP0003806_abnormal_nucleotide_metabolis2.02092815
16MP0002277_abnormal_respiratory_mucosa2.02065060
17MP0009379_abnormal_foot_pigmentation1.99664440
18MP0002837_dystrophic_cardiac_calcinosis1.90961123
19MP0005084_abnormal_gallbladder_morpholo1.88501079
20MP0008995_early_reproductive_senescence1.86448952
21MP0006072_abnormal_retinal_apoptosis1.86153780
22MP0001873_stomach_inflammation1.82808540
23MP0002653_abnormal_ependyma_morphology1.79071643
24MP0003786_premature_aging1.75226004
25MP0002638_abnormal_pupillary_reflex1.74628889
26MP0002166_altered_tumor_susceptibility1.72217761
27MP0005167_abnormal_blood-brain_barrier1.71359539
28MP0004142_abnormal_muscle_tone1.70173741
29MP0008872_abnormal_physiological_respon1.68155609
30MP0001790_abnormal_immune_system1.61601169
31MP0005387_immune_system_phenotype1.61601169
32MP0005551_abnormal_eye_electrophysiolog1.56605706
33MP0005379_endocrine/exocrine_gland_phen1.56409226
34MP0009333_abnormal_splenocyte_physiolog1.54217893
35MP0002148_abnormal_hypersensitivity_rea1.53896766
36MP0001986_abnormal_taste_sensitivity1.51597345
37MP0002006_tumorigenesis1.48478840
38MP0001502_abnormal_circadian_rhythm1.41585302
39MP0009785_altered_susceptibility_to1.40744407
40MP0002138_abnormal_hepatobiliary_system1.39659847
41MP0000631_abnormal_neuroendocrine_gland1.34035902
42MP0000049_abnormal_middle_ear1.30862786
43MP0001800_abnormal_humoral_immune1.29867910
44MP0002163_abnormal_gland_morphology1.29803032
45MP0005253_abnormal_eye_physiology1.28906495
46MP0003186_abnormal_redox_activity1.28845384
47MP0009780_abnormal_chondrocyte_physiolo1.25514560
48MP0001905_abnormal_dopamine_level1.23590270
49MP0009745_abnormal_behavioral_response1.22563154
50MP0001293_anophthalmia1.21938404
51MP0005645_abnormal_hypothalamus_physiol1.21488090
52MP0003718_maternal_effect1.21097430
53MP0001485_abnormal_pinna_reflex1.21085738
54MP0002272_abnormal_nervous_system1.19374626
55MP0003866_abnormal_defecation1.18555184
56MP0003878_abnormal_ear_physiology1.09638624
57MP0005377_hearing/vestibular/ear_phenot1.09638624
58MP0004782_abnormal_surfactant_physiolog1.08683188
59MP0008875_abnormal_xenobiotic_pharmacok1.08112359
60MP0005389_reproductive_system_phenotype1.07970645
61MP0004885_abnormal_endolymph1.01095747
62MP0002282_abnormal_trachea_morphology0.99409064
63MP0003936_abnormal_reproductive_system0.98637701
64MP0001919_abnormal_reproductive_system0.97559993
65MP0002723_abnormal_immune_serum0.96032468
66MP0002234_abnormal_pharynx_morphology0.95567576
67MP0001764_abnormal_homeostasis0.95382887
68MP0003763_abnormal_thymus_physiology0.95294544
69MP0005075_abnormal_melanosome_morpholog0.94947320
70MP0002160_abnormal_reproductive_system0.90481312
71MP0005646_abnormal_pituitary_gland0.87386929
72MP0002420_abnormal_adaptive_immunity0.86580888
73MP0005000_abnormal_immune_tolerance0.86454562
74MP0002822_catalepsy0.86452835
75MP0004019_abnormal_vitamin_homeostasis0.85631564
76MP0001819_abnormal_immune_cell0.85512833
77MP0001853_heart_inflammation0.81577678
78MP0002210_abnormal_sex_determination0.81468906
79MP0004145_abnormal_muscle_electrophysio0.81095312
80MP0003195_calcinosis0.80712892
81MP0006035_abnormal_mitochondrial_morpho0.79499676
82MP0005636_abnormal_mineral_homeostasis0.79160089
83MP0002938_white_spotting0.78620639
84MP0001529_abnormal_vocalization0.78433006
85MP0002733_abnormal_thermal_nociception0.77627996
86MP0002452_abnormal_antigen_presenting0.75465807
87MP0000613_abnormal_salivary_gland0.75281303
88MP0005410_abnormal_fertilization0.74901839
89MP0001958_emphysema0.70761639
90MP0006036_abnormal_mitochondrial_physio0.70153181
91MP0005085_abnormal_gallbladder_physiolo0.69465037
92MP0008058_abnormal_DNA_repair0.69373251
93MP0001346_abnormal_lacrimal_gland0.69187732
94MP0001963_abnormal_hearing_physiology0.68833914
95MP0000653_abnormal_sex_gland0.68590496
96MP0006276_abnormal_autonomic_nervous0.67406311
97MP0005332_abnormal_amino_acid0.67326256
98MP0003938_abnormal_ear_development0.66849790
99MP0001984_abnormal_olfaction0.66763699
100MP0004043_abnormal_pH_regulation0.66086114

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.84013621
2Acute necrotizing encephalopathy (HP:0006965)4.82978205
33-Methylglutaconic aciduria (HP:0003535)4.63408293
4Acute encephalopathy (HP:0006846)4.40698825
5Mitochondrial inheritance (HP:0001427)4.29657251
6Lipid accumulation in hepatocytes (HP:0006561)4.23049611
7Progressive macrocephaly (HP:0004481)4.13783327
8Abnormal mitochondria in muscle tissue (HP:0008316)3.99875439
9Stomatitis (HP:0010280)3.84636262
10Increased CSF lactate (HP:0002490)3.82879285
11Congenital, generalized hypertrichosis (HP:0004540)3.70583412
12IgG deficiency (HP:0004315)3.67255094
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29668122
14Renal Fanconi syndrome (HP:0001994)3.29440615
15Pancreatic cysts (HP:0001737)3.27876580
16Exertional dyspnea (HP:0002875)3.18230268
17Abnormality of the labia minora (HP:0012880)3.13573392
18Increased IgM level (HP:0003496)3.11138318
19Increased intramyocellular lipid droplets (HP:0012240)3.07207570
20Fibular aplasia (HP:0002990)2.98492174
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88797533
22True hermaphroditism (HP:0010459)2.88326136
23Hypoplasia of the pons (HP:0012110)2.87835888
24Congenital stationary night blindness (HP:0007642)2.86250925
25Cerebral edema (HP:0002181)2.77314091
26Optic disc pallor (HP:0000543)2.75742004
27Hepatocellular necrosis (HP:0001404)2.75142357
28Aplastic anemia (HP:0001915)2.71921844
29Abnormality of the pons (HP:0007361)2.69483308
30Elevated erythrocyte sedimentation rate (HP:0003565)2.62113414
31Pancreatic fibrosis (HP:0100732)2.59964606
32Aplasia/hypoplasia of the uterus (HP:0008684)2.57066197
33Synostosis involving the elbow (HP:0003938)2.55640666
34Humeroradial synostosis (HP:0003041)2.55640666
35Respiratory difficulties (HP:0002880)2.49146910
36Increased serum lactate (HP:0002151)2.43286272
37Increased muscle lipid content (HP:0009058)2.42059228
38Leukodystrophy (HP:0002415)2.38761761
39Type II lissencephaly (HP:0007260)2.37527772
40Hepatic necrosis (HP:0002605)2.35465878
41Abnormal rod and cone electroretinograms (HP:0008323)2.34367518
42Septo-optic dysplasia (HP:0100842)2.32107182
43Aplasia/Hypoplasia of the ulna (HP:0006495)2.28641784
44Abnormality of T cell physiology (HP:0011840)2.27472476
45Renal cortical cysts (HP:0000803)2.23719732
46Molar tooth sign on MRI (HP:0002419)2.23603911
47Abnormality of midbrain morphology (HP:0002418)2.23603911
48Lactic acidosis (HP:0003128)2.22939753
49Reticulocytopenia (HP:0001896)2.21888938
50Symphalangism affecting the phalanges of the hand (HP:0009773)2.13372583
51Macrocytic anemia (HP:0001972)2.12129486
52Pancytopenia (HP:0001876)2.10887540
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09991158
54Pendular nystagmus (HP:0012043)2.09713192
55Abnormality of the renal cortex (HP:0011035)2.08592657
56Exercise intolerance (HP:0003546)2.07756570
57Testicular atrophy (HP:0000029)2.07070937
58Abnormality of renal resorption (HP:0011038)2.05089998
59Abnormality of T cells (HP:0002843)2.04352239
60Esophageal atresia (HP:0002032)2.04071961
61Bilateral microphthalmos (HP:0007633)2.03993636
62Nephronophthisis (HP:0000090)2.02721789
63Medial flaring of the eyebrow (HP:0010747)2.02459667
64Autoimmune hemolytic anemia (HP:0001890)2.01619066
65Conical tooth (HP:0000698)2.00284075
66Stenosis of the external auditory canal (HP:0000402)1.99631094
67Methylmalonic acidemia (HP:0002912)1.99149995
68Lethargy (HP:0001254)1.98649648
69Oligodactyly (hands) (HP:0001180)1.96870501
70Autoimmune thrombocytopenia (HP:0001973)1.96405843
71Respiratory failure (HP:0002878)1.95302794
72Abnormal ciliary motility (HP:0012262)1.94045064
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93694455
74Hypoplasia of the radius (HP:0002984)1.91973965
75Dyschromatopsia (HP:0007641)1.90807193
76Hypoplasia of the ulna (HP:0003022)1.89995855
77Increased corneal curvature (HP:0100692)1.88579419
78Keratoconus (HP:0000563)1.88579419
79Optic nerve hypoplasia (HP:0000609)1.86917558
80Abnormality of the middle phalanges of the toes (HP:0010183)1.86227227
81IgM deficiency (HP:0002850)1.86000375
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85795774
83Type 2 muscle fiber atrophy (HP:0003554)1.85176621
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85154618
85Attenuation of retinal blood vessels (HP:0007843)1.84737271
86Sclerocornea (HP:0000647)1.84546234
87Hyperglycinemia (HP:0002154)1.82921001
88Cleft eyelid (HP:0000625)1.80195665
89Abnormal respiratory epithelium morphology (HP:0012253)1.79996110
90Abnormal respiratory motile cilium morphology (HP:0005938)1.79996110
91Abolished electroretinogram (ERG) (HP:0000550)1.77734552
92Constricted visual fields (HP:0001133)1.77212583
93Abnormal number of erythroid precursors (HP:0012131)1.75566004
94Absent septum pellucidum (HP:0001331)1.73213100
95Forearm undergrowth (HP:0009821)1.72182378
96Supernumerary bones of the axial skeleton (HP:0009144)1.71762104
97Abnormality of cells of the erythroid lineage (HP:0012130)1.71440449
98Neutropenia (HP:0001875)1.70840318
99Abnormality of urine glucose concentration (HP:0011016)1.69730683
100Glycosuria (HP:0003076)1.69730683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.70307316
2VRK23.47821069
3PINK13.21254025
4ADRBK23.01275369
5NUAK12.88426637
6TLK12.73488437
7EIF2AK12.72462218
8ZAK2.62119504
9VRK12.59483503
10FRK2.58083840
11MAP4K12.42675727
12GRK11.83845586
13MST41.82868493
14EIF2AK31.81723739
15TSSK61.75038969
16STK161.74550230
17FGFR21.73335582
18PNCK1.52814191
19MAPK151.49388999
20NME11.49301997
21MAPKAPK31.48338718
22FES1.46290447
23WNK41.45048974
24TAF11.39999673
25SCYL21.37427514
26TAOK31.33832694
27WNK31.33777219
28BMPR1B1.27526573
29NEK11.19312689
30GRK71.18649138
31PLK31.15189481
32DYRK21.14565020
33BUB11.11685054
34SRPK11.10974360
35ITK1.09381795
36TEC1.06555386
37PASK1.04335001
38MAP2K61.04164515
39PHKG11.03204758
40PHKG21.03204758
41CSNK1G30.95943885
42KDR0.95284550
43AKT30.91304896
44CSNK1G20.87989069
45MAP4K20.86849548
46PLK40.84682351
47TAOK20.84065203
48WNK10.83758396
49PDK20.81134300
50CSNK1G10.79293107
51CSNK1A1L0.77858729
52MYLK0.77045457
53KIT0.73986709
54DAPK30.73970375
55IKBKB0.72731551
56INSRR0.72645242
57NME20.72595287
58ADRBK10.72388555
59TIE10.71675509
60RPS6KA50.68990773
61MAPKAPK50.66201471
62FGFR10.64402681
63BTK0.62592599
64CDK80.61750641
65GRK50.61030703
66TRIM280.60182825
67EIF2AK20.60073675
68DAPK10.58610543
69ERBB20.57476503
70MAP3K120.55987583
71SYK0.55429996
72CAMKK20.54683038
73LCK0.54409898
74CSNK1A10.54199124
75WEE10.53557128
76PRKCE0.52658979
77PRKCQ0.51281513
78DAPK20.50135026
79CSNK2A20.48357997
80MKNK10.48313811
81MAPKAPK20.47253847
82CASK0.45633077
83OXSR10.45369065
84PRKACA0.45033675
85PRKCG0.44880109
86CSNK2A10.44756957
87OBSCN0.41679749
88IKBKE0.40809374
89PKN10.40526210
90IGF1R0.39663343
91MAPK130.38879140
92MKNK20.37511571
93LYN0.36818060
94CSK0.35792644
95TESK20.34562369
96ACVR1B0.34414119
97AURKB0.33923009
98TYRO30.33529575
99ALK0.33190783
100PLK20.31063141

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.52966411
2Proteasome_Homo sapiens_hsa030504.47596939
3Oxidative phosphorylation_Homo sapiens_hsa001903.84681153
4Parkinsons disease_Homo sapiens_hsa050123.20725017
5Asthma_Homo sapiens_hsa053102.69978766
6RNA polymerase_Homo sapiens_hsa030202.62396751
7Primary immunodeficiency_Homo sapiens_hsa053402.52507250
8Allograft rejection_Homo sapiens_hsa053302.44890120
9Protein export_Homo sapiens_hsa030602.42026172
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.28876417
11Autoimmune thyroid disease_Homo sapiens_hsa053202.19425976
12Alzheimers disease_Homo sapiens_hsa050102.10816247
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06689754
14Huntingtons disease_Homo sapiens_hsa050162.06228655
15Graft-versus-host disease_Homo sapiens_hsa053321.99432378
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92777363
17Homologous recombination_Homo sapiens_hsa034401.81502674
18Type I diabetes mellitus_Homo sapiens_hsa049401.77202469
19Basal transcription factors_Homo sapiens_hsa030221.75638074
20RNA degradation_Homo sapiens_hsa030181.74886888
21Cardiac muscle contraction_Homo sapiens_hsa042601.71184416
22Antigen processing and presentation_Homo sapiens_hsa046121.62246095
23One carbon pool by folate_Homo sapiens_hsa006701.49739588
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44401097
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42715166
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41623305
27Spliceosome_Homo sapiens_hsa030401.37492021
28Mismatch repair_Homo sapiens_hsa034301.37233967
29Linoleic acid metabolism_Homo sapiens_hsa005911.32496257
30Phototransduction_Homo sapiens_hsa047441.27735986
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16618971
32Nitrogen metabolism_Homo sapiens_hsa009101.12010712
33Rheumatoid arthritis_Homo sapiens_hsa053231.11862465
34Pyrimidine metabolism_Homo sapiens_hsa002401.07893446
35Vitamin B6 metabolism_Homo sapiens_hsa007501.05868383
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05354002
37Caffeine metabolism_Homo sapiens_hsa002321.04644838
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00792894
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00783978
40Folate biosynthesis_Homo sapiens_hsa007901.00173944
41RNA transport_Homo sapiens_hsa030130.99268162
42Nucleotide excision repair_Homo sapiens_hsa034200.97828247
43Purine metabolism_Homo sapiens_hsa002300.97739253
44Hematopoietic cell lineage_Homo sapiens_hsa046400.93326514
45Base excision repair_Homo sapiens_hsa034100.91320338
46Regulation of autophagy_Homo sapiens_hsa041400.90459248
47DNA replication_Homo sapiens_hsa030300.89145824
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88215708
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87913088
50T cell receptor signaling pathway_Homo sapiens_hsa046600.85362224
51Chemical carcinogenesis_Homo sapiens_hsa052040.80833196
52Fanconi anemia pathway_Homo sapiens_hsa034600.79649823
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71651459
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70220553
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69117902
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66567314
57Butanoate metabolism_Homo sapiens_hsa006500.63138463
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.62229706
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61729136
60Propanoate metabolism_Homo sapiens_hsa006400.61706894
61Retinol metabolism_Homo sapiens_hsa008300.59468430
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58847488
63Systemic lupus erythematosus_Homo sapiens_hsa053220.58787892
64Metabolic pathways_Homo sapiens_hsa011000.55490678
65Vitamin digestion and absorption_Homo sapiens_hsa049770.54398885
66Non-homologous end-joining_Homo sapiens_hsa034500.53417559
67Olfactory transduction_Homo sapiens_hsa047400.52903627
68Peroxisome_Homo sapiens_hsa041460.52827258
69Arachidonic acid metabolism_Homo sapiens_hsa005900.52664600
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52246016
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.50663532
72Mineral absorption_Homo sapiens_hsa049780.49373083
73Steroid biosynthesis_Homo sapiens_hsa001000.48890298
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48844899
75Tryptophan metabolism_Homo sapiens_hsa003800.45815840
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.44181756
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.44034861
78Taste transduction_Homo sapiens_hsa047420.43595832
79Nicotine addiction_Homo sapiens_hsa050330.43013642
80Epstein-Barr virus infection_Homo sapiens_hsa051690.42074323
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.41944307
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39655348
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37951837
84Measles_Homo sapiens_hsa051620.35860796
85mRNA surveillance pathway_Homo sapiens_hsa030150.35465928
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34518251
87Collecting duct acid secretion_Homo sapiens_hsa049660.34055241
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32882559
89Ether lipid metabolism_Homo sapiens_hsa005650.32727631
90Viral myocarditis_Homo sapiens_hsa054160.32494425
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32258706
92Glutathione metabolism_Homo sapiens_hsa004800.31936627
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31689507
94Fat digestion and absorption_Homo sapiens_hsa049750.27279563
95Malaria_Homo sapiens_hsa051440.26751625
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.26565418
97Glycerolipid metabolism_Homo sapiens_hsa005610.25960148
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25561919
99Sulfur relay system_Homo sapiens_hsa041220.25528741
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19011045

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