ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline transport (GO:0015824)	7.74123076
2	neurotransmitter-gated ion channel clustering (GO:0072578)	7.58225578
3	positive regulation of vesicle fusion (GO:0031340)	6.91677661
4	heparin metabolic process (GO:0030202)	6.29190488
5	heparin biosynthetic process (GO:0030210)	6.29190488
6	response to pheromone (GO:0019236)	5.75023757
7	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.66984271
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.66984271
9	regulation of translation, ncRNA-mediated (GO:0045974)	5.66984271
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	5.53023643
11	polyol catabolic process (GO:0046174)	4.98856492
12	L-methionine salvage (GO:0071267)	4.83419336
13	L-methionine biosynthetic process (GO:0071265)	4.83419336
14	amino acid salvage (GO:0043102)	4.83419336
15	nucleoside diphosphate catabolic process (GO:0009134)	4.62432646
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.41110664
17	glycerol metabolic process (GO:0006071)	4.39332605
18	methionine biosynthetic process (GO:0009086)	4.11642486
19	prostate gland growth (GO:0060736)	4.07585144
20	vocalization behavior (GO:0071625)	4.07520313
21	phosphatidylethanolamine metabolic process (GO:0046337)	4.02913211
22	lactate metabolic process (GO:0006089)	3.92223474
23	alditol metabolic process (GO:0019400)	3.77190358
24	regulation of neurotransmitter uptake (GO:0051580)	3.77053373
25	negative regulation of hormone biosynthetic process (GO:0032353)	3.76723061
26	regulation of male gonad development (GO:2000018)	3.76048106
27	positive regulation of guanylate cyclase activity (GO:0031284)	3.73086705
28	positive regulation of meiosis (GO:0045836)	3.68449878
29	positive regulation of actin cytoskeleton reorganization (GO:2000251)	3.65886817
30	xenobiotic catabolic process (GO:0042178)	3.64679125
31	regulation of acrosome reaction (GO:0060046)	3.64264398
32	regulation of glucokinase activity (GO:0033131)	3.62961943
33	regulation of hexokinase activity (GO:1903299)	3.62961943
34	negative regulation of astrocyte differentiation (GO:0048712)	3.60440544
35	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.60390491
36	regulation of neuron projection regeneration (GO:0070570)	3.58058777
37	regulation of axon regeneration (GO:0048679)	3.58058777
38	auditory behavior (GO:0031223)	3.57790455
39	negative regulation of dendrite development (GO:2000171)	3.56925452
40	cellular carbohydrate catabolic process (GO:0044275)	3.55070920
41	NAD biosynthetic process (GO:0009435)	3.52044445
42	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.51327350
43	behavioral response to ethanol (GO:0048149)	3.44810163
44	lens fiber cell differentiation (GO:0070306)	3.44104079
45	negative regulation of hormone metabolic process (GO:0032351)	3.41162894
46	positive regulation of meiotic cell cycle (GO:0051446)	3.40148340
47	regulation of heat generation (GO:0031650)	3.39129646
48	mechanosensory behavior (GO:0007638)	3.39001867
49	methionine metabolic process (GO:0006555)	3.36560269
50	positive regulation of mitochondrial fission (GO:0090141)	3.36421499
51	dopamine transport (GO:0015872)	3.35338298
52	presynaptic membrane assembly (GO:0097105)	3.33875115
53	regulation of guanylate cyclase activity (GO:0031282)	3.33134252
54	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.32215136
55	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.26412251
56	regulation of vesicle fusion (GO:0031338)	3.25771309
57	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.25522755
58	peptidyl-glutamic acid carboxylation (GO:0017187)	3.25263436
59	protein carboxylation (GO:0018214)	3.25263436
60	oocyte development (GO:0048599)	3.20386088
61	retinal cone cell development (GO:0046549)	3.18348713
62	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.17305691
63	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.17305691
64	preassembly of GPI anchor in ER membrane (GO:0016254)	3.09861102
65	sulfur amino acid biosynthetic process (GO:0000097)	3.09275183
66	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.05326345
67	respiratory chain complex IV assembly (GO:0008535)	3.05067718
68	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.04824989
69	cochlea development (GO:0090102)	3.04418289
70	negative regulation of protein oligomerization (GO:0032460)	3.02123439
71	somite rostral/caudal axis specification (GO:0032525)	3.00609401
72	protein K6-linked ubiquitination (GO:0085020)	2.99754749
73	platelet dense granule organization (GO:0060155)	2.99189897
74	sphingoid metabolic process (GO:0046519)	2.95351716
75	synaptic transmission, glutamatergic (GO:0035249)	2.95289450
76	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.94809107
77	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.89070102
78	aspartate family amino acid biosynthetic process (GO:0009067)	2.88458012
79	glutamate receptor signaling pathway (GO:0007215)	2.87679038
80	S-adenosylmethionine metabolic process (GO:0046500)	2.87528773
81	negative regulation of mast cell activation (GO:0033004)	2.87047076
82	cell differentiation involved in metanephros development (GO:0072202)	2.84925852
83	detection of light stimulus involved in visual perception (GO:0050908)	2.83765312
84	detection of light stimulus involved in sensory perception (GO:0050962)	2.83765312
85	DNA deamination (GO:0045006)	2.83077763
86	protein localization to synapse (GO:0035418)	2.80462620
87	regulation of mitochondrial fission (GO:0090140)	2.78489044
88	peptidyl-glutamic acid modification (GO:0018200)	2.77075456
89	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	2.76829346
90	postsynaptic membrane organization (GO:0001941)	2.76699355
91	reflex (GO:0060004)	2.74714469
92	proline biosynthetic process (GO:0006561)	2.73666872
93	righting reflex (GO:0060013)	2.72837106
94	white fat cell differentiation (GO:0050872)	2.71666726
95	presynaptic membrane organization (GO:0097090)	2.71355803
96	pyridine nucleotide biosynthetic process (GO:0019363)	2.71099995
97	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.71099995
98	purine ribonucleoside diphosphate metabolic process (GO:0009179)	2.70599660
99	purine nucleoside diphosphate metabolic process (GO:0009135)	2.70599660
100	modulation by virus of host process (GO:0019054)	2.68600903

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAF15_26573619_Chip-Seq_HEK293_Human	5.05796519
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.57476222
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.87159721
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.23852614
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.18797003
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.12701816
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.03274330
8	EWS_26573619_Chip-Seq_HEK293_Human	2.74682553
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54231980
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.44016254
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43596266
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36526574
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.17607688
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.15539176
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14026851
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13872445
17	FUS_26573619_Chip-Seq_HEK293_Human	2.07946415
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00838770
19	VDR_22108803_ChIP-Seq_LS180_Human	1.90023329
20	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.88038476
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.86541815
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83852614
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80325974
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78927750
25	AR_25329375_ChIP-Seq_VCAP_Human	1.78894260
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77561020
27	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76605452
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74214704
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.71706946
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69496129
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69496129
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64899535
33	TCF4_23295773_ChIP-Seq_U87_Human	1.62683389
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60943337
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57351408
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56857754
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56028329
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54922393
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.49989862
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47346206
41	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.47218750
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46727119
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45723050
44	STAT3_23295773_ChIP-Seq_U87_Human	1.45547926
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45427471
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.44356316
47	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.43045385
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41320625
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41080043
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40517937
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38932812
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.37369784
53	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.37071911
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.36872543
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.36413227
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35945761
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.33986209
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31486486
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.30150508
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29757654
61	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.28471263
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.27015625
63	TP53_16413492_ChIP-PET_HCT116_Human	1.22780422
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22738758
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.21439838
66	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20589882
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.20241286
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20241286
69	RXR_22108803_ChIP-Seq_LS180_Human	1.20217469
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19975438
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19419793
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18852903
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17287154
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17287154
75	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16269892
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16179753
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16091040
78	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.13006174
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11062545
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10881805
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10881805
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10758331
83	P300_18555785_Chip-Seq_ESCs_Mouse	1.10372777
84	JUN_21703547_ChIP-Seq_K562_Human	1.09492191
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09049283
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06429237
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06165736
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05961624
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05550347
90	NCOR_22424771_ChIP-Seq_293T_Human	1.04656746
91	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03260360
92	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.03221908
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02271649
94	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00337186
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99523075
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99494559
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97714509
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97284663
99	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96777062
100	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.96466090

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	6.42430492
2	MP0002102_abnormal_ear_morphology	4.63267814
3	MP0002837_dystrophic_cardiac_calcinosis	3.43536979
4	MP0008875_abnormal_xenobiotic_pharmacok	3.23888162
5	MP0002139_abnormal_hepatobiliary_system	3.07769820
6	MP0001501_abnormal_sleep_pattern	2.89833703
7	MP0002876_abnormal_thyroid_physiology	2.43465221
8	MP0008961_abnormal_basal_metabolism	2.30649760
9	MP0004043_abnormal_pH_regulation	2.23289239
10	MP0004133_heterotaxia	2.18835812
11	MP0003123_paternal_imprinting	2.18015214
12	MP0002163_abnormal_gland_morphology	2.02110469
13	MP0002160_abnormal_reproductive_system	2.01763682
14	MP0005187_abnormal_penis_morphology	2.00114075
15	MP0002928_abnormal_bile_duct	1.98344797
16	MP0009745_abnormal_behavioral_response	1.93540272
17	MP0002736_abnormal_nociception_after	1.90134022
18	MP0003172_abnormal_lysosome_physiology	1.88285678
19	MP0008995_early_reproductive_senescence	1.84313463
20	MP0001968_abnormal_touch/_nociception	1.77254436
21	MP0000647_abnormal_sebaceous_gland	1.75483613
22	MP0005551_abnormal_eye_electrophysiolog	1.73778566
23	MP0003283_abnormal_digestive_organ	1.71056956
24	MP0002138_abnormal_hepatobiliary_system	1.69668612
25	MP0008058_abnormal_DNA_repair	1.65129866
26	MP0003195_calcinosis	1.53655459
27	MP0000613_abnormal_salivary_gland	1.50689997
28	MP0001486_abnormal_startle_reflex	1.49508892
29	MP0003119_abnormal_digestive_system	1.40591293
30	MP0000569_abnormal_digit_pigmentation	1.38696000
31	MP0004215_abnormal_myocardial_fiber	1.38173542
32	MP0009046_muscle_twitch	1.38059307
33	MP0006036_abnormal_mitochondrial_physio	1.37634691
34	MP0009780_abnormal_chondrocyte_physiolo	1.36486256
35	MP0000462_abnormal_digestive_system	1.34533571
36	MP0002234_abnormal_pharynx_morphology	1.34100630
37	MP0005310_abnormal_salivary_gland	1.33959566
38	MP0005379_endocrine/exocrine_gland_phen	1.32495538
39	MP0010234_abnormal_vibrissa_follicle	1.31001884
40	MP0003633_abnormal_nervous_system	1.30098281
41	MP0003880_abnormal_central_pattern	1.29808521
42	MP0005084_abnormal_gallbladder_morpholo	1.29115185
43	MP0010352_gastrointestinal_tract_polyps	1.27613208
44	MP0005220_abnormal_exocrine_pancreas	1.23977577
45	MP0003786_premature_aging	1.19052970
46	MP0003718_maternal_effect	1.13154898
47	MP0002272_abnormal_nervous_system	1.12282674
48	MP0002064_seizures	1.10595745
49	MP0003635_abnormal_synaptic_transmissio	1.07035698
50	MP0003137_abnormal_impulse_conducting	1.05931042
51	MP0000015_abnormal_ear_pigmentation	1.04346031
52	MP0005167_abnormal_blood-brain_barrier	1.03728564
53	MP0002909_abnormal_adrenal_gland	1.03526969
54	MP0004145_abnormal_muscle_electrophysio	1.03130394
55	MP0002295_abnormal_pulmonary_circulatio	1.00778440
56	MP0003252_abnormal_bile_duct	0.99216626
57	MP0000372_irregular_coat_pigmentation	0.98065094
58	MP0005253_abnormal_eye_physiology	0.96706387
59	MP0002733_abnormal_thermal_nociception	0.91990017
60	MP0003646_muscle_fatigue	0.91707533
61	MP0001756_abnormal_urination	0.90780868
62	MP0000631_abnormal_neuroendocrine_gland	0.90396719
63	MP0008775_abnormal_heart_ventricle	0.89556020
64	MP0003943_abnormal_hepatobiliary_system	0.89484176
65	MP0008872_abnormal_physiological_respon	0.89391356
66	MP0005389_reproductive_system_phenotype	0.89240482
67	MP0001324_abnormal_eye_pigmentation	0.87245336
68	MP0000427_abnormal_hair_cycle	0.85712635
69	MP0002229_neurodegeneration	0.85191836
70	MP0002693_abnormal_pancreas_physiology	0.84237526
71	MP0003938_abnormal_ear_development	0.83691257
72	MP0002233_abnormal_nose_morphology	0.83332657
73	MP0001944_abnormal_pancreas_morphology	0.82188978
74	MP0003937_abnormal_limbs/digits/tail_de	0.81351402
75	MP0004924_abnormal_behavior	0.79951618
76	MP0005386_behavior/neurological_phenoty	0.79951618
77	MP0005636_abnormal_mineral_homeostasis	0.77787849
78	MP0005332_abnormal_amino_acid	0.77305348
79	MP0003755_abnormal_palate_morphology	0.76703211
80	MP0003950_abnormal_plasma_membrane	0.75886106
81	MP0004270_analgesia	0.74078244
82	MP0005410_abnormal_fertilization	0.73579472
83	MP0001764_abnormal_homeostasis	0.73287633
84	MP0004134_abnormal_chest_morphology	0.72932963
85	MP0003045_fibrosis	0.72148416
86	MP0001970_abnormal_pain_threshold	0.71651751
87	MP0001661_extended_life_span	0.70965411
88	MP0005075_abnormal_melanosome_morpholog	0.69918050
89	MP0003183_abnormal_peptide_metabolism	0.69326601
90	MP0001177_atelectasis	0.65538735
91	MP0009764_decreased_sensitivity_to	0.65454197
92	MP0001905_abnormal_dopamine_level	0.65315476
93	MP0004484_altered_response_of	0.65280446
94	MP0008877_abnormal_DNA_methylation	0.65218320
95	MP0002095_abnormal_skin_pigmentation	0.64365182
96	MP0002069_abnormal_eating/drinking_beha	0.63651147
97	MP0001348_abnormal_lacrimal_gland	0.63097132
98	MP0004142_abnormal_muscle_tone	0.63006169
99	MP0002067_abnormal_sensory_capabilities	0.62664464
100	MP0005647_abnormal_sex_gland	0.61588535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased density of long bones (HP:0006392)	5.54131241
2	Calf muscle hypertrophy (HP:0008981)	5.08086161
3	Bile duct proliferation (HP:0001408)	4.66319717
4	Abnormal biliary tract physiology (HP:0012439)	4.66319717
5	Muscle hypertrophy of the lower extremities (HP:0008968)	4.43344730
6	Unilateral renal agenesis (HP:0000122)	4.14407808
7	Increased serum pyruvate (HP:0003542)	4.11922664
8	Slender build (HP:0001533)	4.06457791
9	Pancreatic fibrosis (HP:0100732)	4.02691918
10	Abnormality of glycolysis (HP:0004366)	3.97079470
11	Aplasia/hypoplasia of the uterus (HP:0008684)	3.49739729
12	Pancreatic cysts (HP:0001737)	3.49527045
13	Protruding tongue (HP:0010808)	3.41441861
14	Shoulder girdle muscle weakness (HP:0003547)	3.35524742
15	Hemiparesis (HP:0001269)	3.30347993
16	Difficulty running (HP:0009046)	3.27408605
17	Cerebral hypomyelination (HP:0006808)	3.25941019
18	Prolonged partial thromboplastin time (HP:0003645)	3.24124119
19	Abnormality of the musculature of the pelvis (HP:0001469)	3.22272589
20	Abnormality of the hip-girdle musculature (HP:0001445)	3.22272589
21	True hermaphroditism (HP:0010459)	3.20766954
22	Pelvic girdle muscle weakness (HP:0003749)	3.18468944
23	Progressive inability to walk (HP:0002505)	3.17696181
24	Type II lissencephaly (HP:0007260)	3.12196893
25	Broad-based gait (HP:0002136)	3.03641003
26	Joint hemorrhage (HP:0005261)	3.00003987
27	Hyperventilation (HP:0002883)	2.98337434
28	Prominent metopic ridge (HP:0005487)	2.82544544
29	Sex reversal (HP:0012245)	2.80559226
30	Abnormal sex determination (HP:0012244)	2.80559226
31	CNS hypomyelination (HP:0003429)	2.76995887
32	Absent speech (HP:0001344)	2.73896582
33	3-Methylglutaconic aciduria (HP:0003535)	2.70566377
34	Abnormality of midbrain morphology (HP:0002418)	2.70561676
35	Molar tooth sign on MRI (HP:0002419)	2.70561676
36	Albinism (HP:0001022)	2.70364287
37	Autoamputation (HP:0001218)	2.65474496
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.63057730
39	Neoplasm of the adrenal cortex (HP:0100641)	2.62703073
40	Aqueductal stenosis (HP:0002410)	2.62022652
41	Rib fusion (HP:0000902)	2.59071303
42	Unsteady gait (HP:0002317)	2.58731272
43	Asplenia (HP:0001746)	2.54413248
44	Drooling (HP:0002307)	2.47603077
45	Cerebellar dysplasia (HP:0007033)	2.47355042
46	Hypoglycemic seizures (HP:0002173)	2.41269056
47	Hyperglycinuria (HP:0003108)	2.37349489
48	Abnormality of the calf musculature (HP:0001430)	2.33608737
49	Abnormality of the metopic suture (HP:0005556)	2.33599138
50	Acanthocytosis (HP:0001927)	2.27579724
51	Excessive salivation (HP:0003781)	2.27124942
52	Cystic liver disease (HP:0006706)	2.24838705
53	Poor speech (HP:0002465)	2.23823115
54	Clumsiness (HP:0002312)	2.19420383
55	Widely spaced teeth (HP:0000687)	2.16618081
56	Advanced eruption of teeth (HP:0006288)	2.11181794
57	Sclerocornea (HP:0000647)	2.09921858
58	Enlarged penis (HP:0000040)	2.09508695
59	Hypoglycemic coma (HP:0001325)	2.09425060
60	Abnormality of alanine metabolism (HP:0010916)	2.04218327
61	Hyperalaninemia (HP:0003348)	2.04218327
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04218327
63	Increased hepatocellular lipid droplets (HP:0006565)	2.03389077
64	Nephronophthisis (HP:0000090)	2.01976813
65	Lipid accumulation in hepatocytes (HP:0006561)	2.00606769
66	Furrowed tongue (HP:0000221)	1.97673099
67	Hypothermia (HP:0002045)	1.97622875
68	Barrel-shaped chest (HP:0001552)	1.95311376
69	Chronic hepatic failure (HP:0100626)	1.94541922
70	Postaxial foot polydactyly (HP:0001830)	1.94415782
71	Proximal amyotrophy (HP:0007126)	1.93607230
72	Intrahepatic cholestasis (HP:0001406)	1.89099273
73	Supernumerary spleens (HP:0009799)	1.88951993
74	Fair hair (HP:0002286)	1.88378143
75	Stomach cancer (HP:0012126)	1.87429843
76	Acute encephalopathy (HP:0006846)	1.86727888
77	Lower limb hyperreflexia (HP:0002395)	1.83566322
78	Congenital stationary night blindness (HP:0007642)	1.82997339
79	Enlarged kidneys (HP:0000105)	1.82380700
80	Ketosis (HP:0001946)	1.82307418
81	Occipital encephalocele (HP:0002085)	1.82193607
82	Breast carcinoma (HP:0003002)	1.81922777
83	Glioma (HP:0009733)	1.81507891
84	Inability to walk (HP:0002540)	1.81489476
85	Colon cancer (HP:0003003)	1.80954555
86	Osteomyelitis (HP:0002754)	1.80061784
87	Renal agenesis (HP:0000104)	1.79837665
88	Abnormality of the renal cortex (HP:0011035)	1.79017082
89	Back pain (HP:0003418)	1.78064068
90	Abnormality of lateral ventricle (HP:0030047)	1.78039072
91	Abnormality of the common coagulation pathway (HP:0010990)	1.77292906
92	Progressive cerebellar ataxia (HP:0002073)	1.76483806
93	Abolished electroretinogram (ERG) (HP:0000550)	1.76222865
94	Hyperglycinemia (HP:0002154)	1.75274457
95	Abnormality of the renal medulla (HP:0100957)	1.74885167
96	Medial flaring of the eyebrow (HP:0010747)	1.74723959
97	Premature ovarian failure (HP:0008209)	1.74634894
98	Hyperinsulinemic hypoglycemia (HP:0000825)	1.74350615
99	Renal Fanconi syndrome (HP:0001994)	1.73825005
100	Congenital malformation of the right heart (HP:0011723)	1.73813214

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	7.45290497
2	FRK	5.29315918
3	NTRK3	5.15523090
4	EIF2AK1	3.95579485
5	MAP4K2	2.97753095
6	EIF2AK3	2.92333573
7	TNIK	2.70210098
8	STK38L	2.26668243
9	MAPK13	2.20852400
10	NEK1	2.09828412
11	ERBB3	2.08869629
12	FGFR2	1.95185863
13	TTK	1.85178902
14	MST4	1.83559709
15	PHKG1	1.82653002
16	PHKG2	1.82653002
17	ADRBK2	1.81489599
18	MKNK2	1.78146658
19	TLK1	1.38127506
20	PIK3CA	1.35833202
21	GRK1	1.34159532
22	MAP3K4	1.33211814
23	BRAF	1.32016412
24	INSRR	1.22113453
25	BMPR2	1.17510851
26	NEK6	1.17343214
27	NUAK1	1.16819982
28	ZAK	1.15779713
29	MARK1	1.01440902
30	PINK1	0.98012298
31	LIMK1	0.96285210
32	MAP2K7	0.91005409
33	CSNK1A1L	0.87769079
34	PLK3	0.87137101
35	BCR	0.83163464
36	FGR	0.81970577
37	CSNK1G3	0.74887050
38	EPHA4	0.72688593
39	SIK2	0.69799411
40	VRK1	0.66142466
41	FER	0.64753020
42	TAOK3	0.62765724
43	CSNK1G1	0.58822624
44	IRAK2	0.56790126
45	PRKCH	0.56660699
46	PRKCE	0.55326137
47	TEC	0.55256401
48	TRPM7	0.54901405
49	NLK	0.54884308
50	EIF2AK2	0.53879726
51	ROCK2	0.53324740
52	STK24	0.52495594
53	CSNK1G2	0.52053761
54	MKNK1	0.51299992
55	MET	0.50020140
56	GRK5	0.49347251
57	IRAK1	0.48281970
58	PRKCI	0.46732892
59	CSNK1E	0.45412575
60	CSNK1D	0.45099217
61	PRKCG	0.44824096
62	PRKAA2	0.44163197
63	STK11	0.44147991
64	BMPR1B	0.44132714
65	AKT3	0.42523095
66	PTK2B	0.41606407
67	MAPKAPK3	0.41344112
68	IGF1R	0.40379278
69	PRKCZ	0.39996904
70	PLK2	0.39799312
71	MST1R	0.38078930
72	PRKG1	0.37472093
73	TNK2	0.36907672
74	HIPK2	0.35377391
75	ROCK1	0.34463616
76	LMTK2	0.33914103
77	ATR	0.33377777
78	ATM	0.31114166
79	OXSR1	0.30040046
80	RPS6KB1	0.29513676
81	PLK1	0.29365497
82	CDC42BPA	0.29307424
83	DYRK2	0.28147717
84	SGK2	0.27768814
85	ABL1	0.27701852
86	PAK3	0.27637499
87	IKBKB	0.27512456
88	ILK	0.26158456
89	STK39	0.25000021
90	CDK5	0.23965791
91	BCKDK	0.22318784
92	BMX	0.19866240
93	PRKCA	0.19528724
94	CSF1R	0.18986241
95	PRKACA	0.18961932
96	PRKACB	0.18826653
97	PRKDC	0.18313727
98	WNK4	0.18192703
99	ADRBK1	0.18124735
100	CSNK2A1	0.16507508

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.02669492
2	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	3.70070070
3	Butanoate metabolism_Homo sapiens_hsa00650	3.64505011
4	Phototransduction_Homo sapiens_hsa04744	3.20559622
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.74447583
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70467430
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.59455632
8	Taste transduction_Homo sapiens_hsa04742	2.48355017
9	Nicotine addiction_Homo sapiens_hsa05033	2.22567637
10	Homologous recombination_Homo sapiens_hsa03440	1.97089025
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.89577952
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81618194
13	Sphingolipid metabolism_Homo sapiens_hsa00600	1.80537780
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80342211
15	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.73931556
16	One carbon pool by folate_Homo sapiens_hsa00670	1.69301277
17	Circadian rhythm_Homo sapiens_hsa04710	1.69165837
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68812747
19	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.58620418
20	Fatty acid elongation_Homo sapiens_hsa00062	1.57906005
21	Caffeine metabolism_Homo sapiens_hsa00232	1.56724507
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54126764
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.52301914
24	Propanoate metabolism_Homo sapiens_hsa00640	1.50566749
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.48799855
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.36972540
27	Proteasome_Homo sapiens_hsa03050	1.33212574
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32184186
29	RNA degradation_Homo sapiens_hsa03018	1.31112854
30	Sulfur metabolism_Homo sapiens_hsa00920	1.29860202
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.29402613
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.29214992
33	Circadian entrainment_Homo sapiens_hsa04713	1.21646665
34	Amphetamine addiction_Homo sapiens_hsa05031	1.19517645
35	Insulin secretion_Homo sapiens_hsa04911	1.19344434
36	Basal transcription factors_Homo sapiens_hsa03022	1.16857785
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15361732
38	RNA polymerase_Homo sapiens_hsa03020	1.10868727
39	Salivary secretion_Homo sapiens_hsa04970	1.09906662
40	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07811371
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.05578979
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.04549670
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04223266
44	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.04042287
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01099428
46	Long-term depression_Homo sapiens_hsa04730	1.00522713
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98639757
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.97378187
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96928432
50	Retinol metabolism_Homo sapiens_hsa00830	0.91958634
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89771047
52	Protein export_Homo sapiens_hsa03060	0.83753057
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82713186
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82570117
55	Olfactory transduction_Homo sapiens_hsa04740	0.81456298
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.81220615
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.78604135
58	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.78136488
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76045002
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75188812
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74956238
62	Dopaminergic synapse_Homo sapiens_hsa04728	0.73501024
63	Glucagon signaling pathway_Homo sapiens_hsa04922	0.71181368
64	Metabolic pathways_Homo sapiens_hsa01100	0.68812828
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67271098
66	Peroxisome_Homo sapiens_hsa04146	0.66864180
67	Fatty acid degradation_Homo sapiens_hsa00071	0.66780383
68	Purine metabolism_Homo sapiens_hsa00230	0.66634525
69	p53 signaling pathway_Homo sapiens_hsa04115	0.64368048
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.63131053
71	Parkinsons disease_Homo sapiens_hsa05012	0.59535582
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58865366
73	Sulfur relay system_Homo sapiens_hsa04122	0.55576544
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53716144
75	Mineral absorption_Homo sapiens_hsa04978	0.53071946
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51321714
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51151403
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49821035
79	Folate biosynthesis_Homo sapiens_hsa00790	0.48000691
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47874227
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46732198
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.46429060
83	Alzheimers disease_Homo sapiens_hsa05010	0.45908514
84	Cocaine addiction_Homo sapiens_hsa05030	0.44242634
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42327180
86	Complement and coagulation cascades_Homo sapiens_hsa04610	0.42252247
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41114279
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.40844455
89	Huntingtons disease_Homo sapiens_hsa05016	0.39967894
90	Renin secretion_Homo sapiens_hsa04924	0.36165696
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33640109
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.30230119
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29295084
94	Regulation of autophagy_Homo sapiens_hsa04140	0.24774099
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.24710424
96	mTOR signaling pathway_Homo sapiens_hsa04150	0.24691073
97	RNA transport_Homo sapiens_hsa03013	0.24445958
98	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.23574325
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.23021396
100	African trypanosomiasis_Homo sapiens_hsa05143	0.22427894

RPL23AP63

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »