RPL23AP64

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of isotype switching (GO:0045830)5.06248711
2negative thymic T cell selection (GO:0045060)5.03692335
3negative T cell selection (GO:0043383)5.02828635
4positive T cell selection (GO:0043368)4.90647489
5positive regulation of granulocyte differentiation (GO:0030854)4.87437695
6positive regulation of DNA recombination (GO:0045911)4.83457531
7regulation of isotype switching to IgG isotypes (GO:0048302)4.76655117
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.67296632
9histone H3-K36 demethylation (GO:0070544)4.51125366
10positive thymic T cell selection (GO:0045059)4.47441328
11thymic T cell selection (GO:0045061)4.36558270
12positive regulation of gamma-delta T cell activation (GO:0046645)4.34424436
13regulation of regulatory T cell differentiation (GO:0045589)4.21200836
14leukocyte aggregation (GO:0070486)4.21194343
15activated T cell proliferation (GO:0050798)4.19819164
16T cell selection (GO:0045058)4.15941755
17negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.11147045
18negative regulation of T-helper cell differentiation (GO:0045623)4.11147045
19ribosomal small subunit biogenesis (GO:0042274)4.02418445
20regulation of immunoglobulin secretion (GO:0051023)3.99586059
21negative regulation of cell killing (GO:0031342)3.82110331
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82110331
23regulation of RNA export from nucleus (GO:0046831)3.74674490
24interferon-gamma production (GO:0032609)3.73951965
25T cell migration (GO:0072678)3.72744013
26response to interleukin-15 (GO:0070672)3.72721619
27negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61826889
28regulation of isotype switching (GO:0045191)3.61822203
29regulation of granulocyte differentiation (GO:0030852)3.61279557
30monoubiquitinated protein deubiquitination (GO:0035520)3.46569030
31positive regulation of immunoglobulin production (GO:0002639)3.45078756
32histone H3-K4 trimethylation (GO:0080182)3.44624048
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44355764
34regulation of histone H3-K27 methylation (GO:0061085)3.36325647
35nuclear pore complex assembly (GO:0051292)3.34550411
36hepatocyte apoptotic process (GO:0097284)3.34106284
37alpha-beta T cell activation (GO:0046631)3.33227997
38cellular response to interleukin-15 (GO:0071350)3.31275542
39protein K11-linked deubiquitination (GO:0035871)3.28016124
40positive regulation of B cell mediated immunity (GO:0002714)3.22948438
41positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22948438
42positive regulation of B cell proliferation (GO:0030890)3.21805386
43peptidyl-lysine trimethylation (GO:0018023)3.19894007
44alpha-beta T cell differentiation (GO:0046632)3.19865505
45production of molecular mediator involved in inflammatory response (GO:0002532)3.17504514
46positive regulation of defense response to virus by host (GO:0002230)3.17358411
47phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15873131
48regulation of immunoglobulin production (GO:0002637)3.10525758
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08681484
50regulation of gamma-delta T cell differentiation (GO:0045586)3.08198467
51regulation of B cell receptor signaling pathway (GO:0050855)3.06422906
52negative regulation of translational initiation (GO:0045947)3.02571570
53CD4-positive, alpha-beta T cell activation (GO:0035710)3.01046493
54viral transcription (GO:0019083)2.99557034
55T-helper cell differentiation (GO:0042093)2.98382077
56CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.98382077
57positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98201604
58regulation of alpha-beta T cell differentiation (GO:0046637)2.97721148
59regulation of memory T cell differentiation (GO:0043380)2.97134113
60tolerance induction (GO:0002507)2.96807086
61mast cell activation (GO:0045576)2.96450246
62CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.96327151
63embryonic hemopoiesis (GO:0035162)2.94982213
64negative regulation of B cell apoptotic process (GO:0002903)2.94307285
65histone deubiquitination (GO:0016578)2.92175973
66regulation of gamma-delta T cell activation (GO:0046643)2.90305848
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90295097
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.90295097
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90295097
70cellular extravasation (GO:0045123)2.88872551
71purine nucleotide salvage (GO:0032261)2.83678894
72response to muramyl dipeptide (GO:0032495)2.83204332
73cytoplasmic mRNA processing body assembly (GO:0033962)2.82562762
74nuclear pore organization (GO:0006999)2.81698394
75positive regulation of alpha-beta T cell differentiation (GO:0046638)2.81339305
76translational termination (GO:0006415)2.81194571
77regulation of nucleobase-containing compound transport (GO:0032239)2.80490909
78alpha-beta T cell differentiation involved in immune response (GO:0002293)2.79133430
79alpha-beta T cell activation involved in immune response (GO:0002287)2.79133430
80T cell differentiation involved in immune response (GO:0002292)2.79133430
81T cell differentiation (GO:0030217)2.77639315
82positive regulation of interleukin-17 production (GO:0032740)2.77571972
83positive regulation of T cell differentiation (GO:0045582)2.75486491
84ribosomal small subunit assembly (GO:0000028)2.74576751
85positive regulation of B cell activation (GO:0050871)2.73831852
86mast cell degranulation (GO:0043303)2.72756841
87mast cell activation involved in immune response (GO:0002279)2.72756841
88ribosomal large subunit biogenesis (GO:0042273)2.71360493
89N-terminal protein amino acid acetylation (GO:0006474)2.70580616
90regulation of B cell proliferation (GO:0030888)2.70118536
91V(D)J recombination (GO:0033151)2.68670667
92regulation of alpha-beta T cell activation (GO:0046634)2.68582530
93positive regulation of alpha-beta T cell activation (GO:0046635)2.67889305
94negative regulation of alpha-beta T cell differentiation (GO:0046639)2.66786893
95Peyers patch development (GO:0048541)2.66214225
96mucosal-associated lymphoid tissue development (GO:0048537)2.66214225
97regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.64873223
98regulation of alpha-beta T cell proliferation (GO:0046640)2.64209925
99regulation of fibroblast apoptotic process (GO:2000269)2.62668580
100negative regulation of T cell mediated immunity (GO:0002710)2.61514799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25847801
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49607526
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.88298574
4MYC_22102868_ChIP-Seq_BL_Human3.50041756
5RUNX_20019798_ChIP-Seq_JUKART_Human3.38146388
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.37790853
7MYB_26560356_Chip-Seq_TH2_Human2.96625390
8ZNF263_19887448_ChIP-Seq_K562_Human2.66914601
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60667929
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53229978
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52885020
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41305671
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39008640
14MAF_26560356_Chip-Seq_TH1_Human2.36263806
15MYB_26560356_Chip-Seq_TH1_Human2.33190872
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32418012
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.32362752
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32042316
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20401285
20VDR_23849224_ChIP-Seq_CD4+_Human2.20211185
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.14015630
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13355228
23GATA3_27048872_Chip-Seq_THYMUS_Human2.10596452
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09673262
25CIITA_25753668_ChIP-Seq_RAJI_Human2.08509441
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.07478549
27VDR_21846776_ChIP-Seq_THP-1_Human2.00725733
28MAF_26560356_Chip-Seq_TH2_Human1.96537201
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94253836
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.92451373
31SPI1_23547873_ChIP-Seq_NB4_Human1.91285621
32UTX_26944678_Chip-Seq_JUKART_Human1.77162268
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71430907
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.67550492
35FOXP3_21729870_ChIP-Seq_TREG_Human1.66151965
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64683634
37SCL_19346495_ChIP-Seq_HPC-7_Human1.63650454
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62140900
39KDM5A_27292631_Chip-Seq_BREAST_Human1.59650181
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58621766
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55484939
42DCP1A_22483619_ChIP-Seq_HELA_Human1.55479414
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55117812
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55074387
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53627213
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53565715
47GATA3_26560356_Chip-Seq_TH2_Human1.51332266
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50800346
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.50503309
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49673482
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47203671
52TFEB_21752829_ChIP-Seq_HELA_Human1.47199225
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44756756
54VDR_24763502_ChIP-Seq_THP-1_Human1.44252589
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.43459609
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37405371
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.35909983
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33568996
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33421271
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32643044
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.30536529
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28779417
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28256184
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27963344
65TCF7_22412390_ChIP-Seq_EML_Mouse1.25603770
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24519400
67KDM2B_26808549_Chip-Seq_DND41_Human1.23139158
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22097472
69E2F7_22180533_ChIP-Seq_HELA_Human1.17987195
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17217395
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16933295
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.16380039
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13870122
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13398309
75CHD1_26751641_Chip-Seq_LNCaP_Human1.12545704
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09232833
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08016873
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07456253
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.06244558
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06037183
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.03827987
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02563827
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02352673
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01826326
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01816598
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98747027
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98641664
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95293164
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94067890
90XRN2_22483619_ChIP-Seq_HELA_Human0.93522177
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91102483
92SPI1_23127762_ChIP-Seq_K562_Human0.90593031
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90222352
94GABP_19822575_ChIP-Seq_HepG2_Human0.88716802
95ELK1_19687146_ChIP-ChIP_HELA_Human0.87962131
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87020596
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86173636
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85675096
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85604440
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83756013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.86347850
2MP0008057_abnormal_DNA_replication3.94955741
3MP0001835_abnormal_antigen_presentation3.77214323
4MP0002009_preneoplasia3.33439177
5MP0003646_muscle_fatigue3.21883394
6MP0001348_abnormal_lacrimal_gland3.17205355
7MP0001873_stomach_inflammation2.90188874
8MP0002166_altered_tumor_susceptibility2.83524601
9MP0005671_abnormal_response_to2.67632914
10MP0000685_abnormal_immune_system2.61406091
11MP0003300_gastrointestinal_ulcer2.50429595
12MP0000703_abnormal_thymus_morphology2.43042297
13MP0001800_abnormal_humoral_immune2.41685321
14MP0003436_decreased_susceptibility_to2.37109594
15MP0002006_tumorigenesis2.03127746
16MP0005000_abnormal_immune_tolerance2.02367707
17MP0003724_increased_susceptibility_to2.01710688
18MP0002398_abnormal_bone_marrow1.94693362
19MP0002420_abnormal_adaptive_immunity1.91934098
20MP0001819_abnormal_immune_cell1.87021243
21MP0001853_heart_inflammation1.86724530
22MP0009379_abnormal_foot_pigmentation1.85549054
23MP0005310_abnormal_salivary_gland1.85510973
24MP0009333_abnormal_splenocyte_physiolog1.83476022
25MP0005387_immune_system_phenotype1.82928359
26MP0001790_abnormal_immune_system1.82928359
27MP0002396_abnormal_hematopoietic_system1.82109605
28MP0002723_abnormal_immune_serum1.81314204
29MP0001188_hyperpigmentation1.78490895
30MP0001849_ear_inflammation1.75503272
31MP0004381_abnormal_hair_follicle1.74864404
32MP0004808_abnormal_hematopoietic_stem1.72598652
33MP0002722_abnormal_immune_system1.72367021
34MP0002877_abnormal_melanocyte_morpholog1.66214273
35MP0000689_abnormal_spleen_morphology1.60203479
36MP0000716_abnormal_immune_system1.58959028
37MP0005025_abnormal_response_to1.58826548
38MP0002452_abnormal_antigen_presenting1.57453569
39MP0002405_respiratory_system_inflammati1.56941570
40MP0010094_abnormal_chromosome_stability1.54525331
41MP0002163_abnormal_gland_morphology1.43475825
42MP0002148_abnormal_hypersensitivity_rea1.37478201
43MP0002429_abnormal_blood_cell1.37247447
44MP0000465_gastrointestinal_hemorrhage1.29917768
45MP0010155_abnormal_intestine_physiology1.28927257
46MP0002933_joint_inflammation1.24907895
47MP0008058_abnormal_DNA_repair1.22723163
48MP0005076_abnormal_cell_differentiation1.21188934
49MP0009785_altered_susceptibility_to1.21004479
50MP0000490_abnormal_crypts_of1.20789848
51MP0004264_abnormal_extraembryonic_tissu1.18792546
52MP0005451_abnormal_body_composition1.16348215
53MP0002419_abnormal_innate_immunity1.13612664
54MP0004858_abnormal_nervous_system1.12594387
55MP0005360_urolithiasis1.12264028
56MP0003077_abnormal_cell_cycle1.08051013
57MP0005464_abnormal_platelet_physiology1.07910987
58MP0003866_abnormal_defecation1.07397032
59MP0002132_abnormal_respiratory_system1.06971372
60MP0001661_extended_life_span1.05407213
61MP0003221_abnormal_cardiomyocyte_apopto1.00824192
62MP0008877_abnormal_DNA_methylation1.00712847
63MP0004947_skin_inflammation0.98242608
64MP0003045_fibrosis0.97412451
65MP0002019_abnormal_tumor_incidence0.97290237
66MP0003567_abnormal_fetal_cardiomyocyte0.96925875
67MP0004233_abnormal_muscle_weight0.92314859
68MP0001845_abnormal_inflammatory_respons0.92293769
69MP0002127_abnormal_cardiovascular_syste0.89125280
70MP0000427_abnormal_hair_cycle0.86572081
71MP0001764_abnormal_homeostasis0.85816892
72MP0002837_dystrophic_cardiac_calcinosis0.83621826
73MP0003959_abnormal_lean_body0.79153690
74MP0001533_abnormal_skeleton_physiology0.78839794
75MP0010307_abnormal_tumor_latency0.77403060
76MP0005075_abnormal_melanosome_morpholog0.76964301
77MP0001502_abnormal_circadian_rhythm0.76845571
78MP0000733_abnormal_muscle_development0.76684813
79MP0004484_altered_response_of0.76272976
80MP0000858_altered_metastatic_potential0.75368877
81MP0002693_abnormal_pancreas_physiology0.74175345
82MP0010352_gastrointestinal_tract_polyps0.73952861
83MP0001919_abnormal_reproductive_system0.72318744
84MP0002254_reproductive_system_inflammat0.68628174
85MP0009697_abnormal_copulation0.68353215
86MP0009278_abnormal_bone_marrow0.65269105
87MP0000470_abnormal_stomach_morphology0.64645949
88MP0001851_eye_inflammation0.63641370
89MP0000015_abnormal_ear_pigmentation0.62725003
90MP0003111_abnormal_nucleus_morphology0.61831445
91MP0000477_abnormal_intestine_morphology0.61426825
92MP0004957_abnormal_blastocyst_morpholog0.61167331
93MP0003786_premature_aging0.60360790
94MP0002088_abnormal_embryonic_growth/wei0.59318015
95MP0005379_endocrine/exocrine_gland_phen0.58366943
96MP0003984_embryonic_growth_retardation0.58110054
97MP0000350_abnormal_cell_proliferation0.57115048
98MP0004185_abnormal_adipocyte_glucose0.54237633
99MP0001730_embryonic_growth_arrest0.53945422
100MP0004130_abnormal_muscle_cell0.53137908

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)4.59904240
2Autoimmune hemolytic anemia (HP:0001890)4.18604341
3T lymphocytopenia (HP:0005403)4.18353044
4Methylmalonic acidemia (HP:0002912)4.14329452
5Panhypogammaglobulinemia (HP:0003139)4.12812694
6Autoimmune thrombocytopenia (HP:0001973)4.07440820
7Stomatitis (HP:0010280)3.95694219
8Abnormality of T cells (HP:0002843)3.77409401
9Abnormality of T cell number (HP:0011839)3.68080679
10Recurrent viral infections (HP:0004429)3.54794875
11B lymphocytopenia (HP:0010976)3.50662363
12Abnormality of T cell physiology (HP:0011840)3.49653999
13Combined immunodeficiency (HP:0005387)3.41449349
14Recurrent fungal infections (HP:0002841)3.30438887
15Abnormality of DNA repair (HP:0003254)3.21217336
16IgG deficiency (HP:0004315)3.18035300
17Abnormality of B cell number (HP:0010975)3.16392208
18Eczematoid dermatitis (HP:0000976)3.04658179
19Hyperglycinemia (HP:0002154)3.02268935
20Ketosis (HP:0001946)2.99817835
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91374167
22Abnormality of the vitamin B12 metabolism (HP:0004341)2.90695415
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.88671262
24Deep palmar crease (HP:0006191)2.87049966
25Acute hepatic failure (HP:0006554)2.84388802
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.83222938
27Abnormality of eosinophils (HP:0001879)2.83067878
28Recurrent cutaneous fungal infections (HP:0011370)2.75409625
29Chronic mucocutaneous candidiasis (HP:0002728)2.75409625
30Basal cell carcinoma (HP:0002671)2.68833627
31Ketoacidosis (HP:0001993)2.60831490
32Visual hallucinations (HP:0002367)2.59454288
33Neutropenia (HP:0001875)2.55741866
34Pustule (HP:0200039)2.53149223
35Hypoplasia of the thymus (HP:0000778)2.51772455
36Abnormality of vitamin B metabolism (HP:0004340)2.49150915
37Methylmalonic aciduria (HP:0012120)2.46104807
38Elevated erythrocyte sedimentation rate (HP:0003565)2.45393727
39Thyroiditis (HP:0100646)2.45259028
40Abnormality of the parietal bone (HP:0002696)2.41989991
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38656738
42Lymphoma (HP:0002665)2.37893360
43Papilledema (HP:0001085)2.37645354
44Aplasia/Hypoplasia of the thymus (HP:0010515)2.37573633
45Eosinophilia (HP:0001880)2.30961451
46Granulocytopenia (HP:0001913)2.30084912
47Increased cerebral lipofuscin (HP:0011813)2.26711502
48Lymphopenia (HP:0001888)2.23896889
49Alveolar cell carcinoma (HP:0006519)2.12402235
50Neoplasm of the tracheobronchial system (HP:0100552)2.12221391
51Testicular atrophy (HP:0000029)2.09859260
52Verrucae (HP:0200043)2.09826503
53Papilloma (HP:0012740)2.09826503
54Increased density of long bones (HP:0006392)2.09389266
55Cutaneous melanoma (HP:0012056)2.09202312
56Acute lymphatic leukemia (HP:0006721)2.04877752
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.01026247
58Encephalitis (HP:0002383)2.00766610
59Microvesicular hepatic steatosis (HP:0001414)1.97174450
60Cheilitis (HP:0100825)1.95791792
61Dislocated radial head (HP:0003083)1.93784098
62Cystic hygroma (HP:0000476)1.93454596
63Teleangiectasia of the skin (HP:0100585)1.91809228
64Increased IgM level (HP:0003496)1.91605720
65Subacute progressive viral hepatitis (HP:0006572)1.90554774
66Submucous cleft hard palate (HP:0000176)1.89998414
67Proximal amyotrophy (HP:0007126)1.88592115
68Trigonocephaly (HP:0000243)1.88444871
69IgM deficiency (HP:0002850)1.88233830
70Macrocytic anemia (HP:0001972)1.87034651
71Viral hepatitis (HP:0006562)1.87004302
72Prominent metopic ridge (HP:0005487)1.84306017
73Abnormality of the thymus (HP:0000777)1.82234641
74Leukocytosis (HP:0001974)1.81279285
75Meningitis (HP:0001287)1.79672443
76Asplenia (HP:0001746)1.79242899
77Dyschromatopsia (HP:0007641)1.79102854
78Abnormality of homocysteine metabolism (HP:0010919)1.78752275
79Homocystinuria (HP:0002156)1.78752275
80Melanoma (HP:0002861)1.78535441
81Hamartoma of the eye (HP:0010568)1.78237953
82Agammaglobulinemia (HP:0004432)1.78145086
83Abnormality of cells of the erythroid lineage (HP:0012130)1.77290985
84Abnormality of oral frenula (HP:0000190)1.77097918
85Cubitus valgus (HP:0002967)1.77001606
86Abnormality of the radial head (HP:0003995)1.75998680
87Hepatitis (HP:0012115)1.75135576
88Spontaneous hematomas (HP:0007420)1.73614561
89Curly hair (HP:0002212)1.72629204
90Abnormality of the columella (HP:0009929)1.70586569
91Cafe-au-lait spot (HP:0000957)1.70059167
92Abnormal foot bone ossification (HP:0010675)1.69645647
93Prostate neoplasm (HP:0100787)1.69636863
94Meningioma (HP:0002858)1.69606500
95Parakeratosis (HP:0001036)1.68108253
96Prominent nose (HP:0000448)1.67532925
97IgA deficiency (HP:0002720)1.67500357
98Supernumerary bones of the axial skeleton (HP:0009144)1.67430057
99Vasculitis (HP:0002633)1.66769049
100Abnormality of the fingertips (HP:0001211)1.66354736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.24612056
2TXK3.92810479
3AKT32.93277176
4CAMKK22.81011674
5MAP3K132.63950398
6PRPF4B2.51818304
7BRD42.51377179
8ZAP702.25156744
9BMPR22.11710157
10MAP3K102.06444420
11EPHB11.91768306
12CDK121.84801465
13MAP3K141.84288197
14NLK1.80823199
15MARK31.75568740
16ITK1.68291397
17FES1.67118752
18CAMK1D1.63182115
19GRK61.59939337
20BTK1.58181286
21BRAF1.57236267
22MAP2K31.55156936
23NME21.52563421
24JAK11.38996609
25PASK1.37985262
26SIK31.32932313
27MAP3K91.32570264
28CDK61.26522072
29CDK41.24468285
30CSK1.20018437
31IKBKB1.15978525
32CAMKK11.11910844
33MUSK1.10739784
34TRIM281.10494581
35ZAK1.09268377
36SMG11.09156372
37BLK1.08476747
38TAOK31.07766320
39TEC1.07734700
40NEK11.06078690
41HIPK21.05085688
42MKNK21.04930784
43MELK1.04112940
44CAMK1G1.00633129
45SYK0.95642289
46NEK90.95036181
47RPS6KB10.93014114
48JAK30.92656488
49IRAK40.89429826
50SGK20.89202810
51GRK10.88845924
52IKBKE0.88760632
53OBSCN0.84936770
54LCK0.82798489
55RPS6KL10.78921561
56RPS6KC10.78921561
57HCK0.78410697
58PKN20.78102620
59TESK20.77568313
60RPS6KA60.77334576
61EIF2AK30.76172643
62MAP2K20.75136105
63PRKCQ0.74637254
64RPS6KB20.73162139
65CAMK40.68366610
66FGFR30.67818516
67PIM10.67232148
68TAOK20.66967346
69TLK10.64807509
70TRPM70.62361816
71TTN0.59595200
72STK40.56316518
73MTOR0.56046242
74PIK3CG0.54589138
75ADRBK20.54205982
76MKNK10.53994632
77TRIB30.53646384
78PLK40.52545724
79BRSK20.52506733
80SIK10.50346713
81SGK30.50270362
82LYN0.50201866
83ATR0.48984748
84ICK0.48174693
85MAP3K70.47049407
86TAF10.46679540
87RIPK40.46247776
88MAP3K10.46016507
89RPS6KA40.43750541
90SGK10.43536066
91GRK70.41992122
92SGK2230.41464435
93SGK4940.41464435
94CHUK0.40533240
95CDK90.39724923
96MAPK120.37729728
97CHEK10.37156887
98FGFR40.36729088
99PDGFRB0.36586004
100EEF2K0.31793725

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.60620037
2T cell receptor signaling pathway_Homo sapiens_hsa046603.45866622
3Allograft rejection_Homo sapiens_hsa053302.39078160
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.38401578
5B cell receptor signaling pathway_Homo sapiens_hsa046622.24776228
6Autoimmune thyroid disease_Homo sapiens_hsa053202.19163788
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.10126150
8Measles_Homo sapiens_hsa051622.05930329
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03691400
10Ribosome_Homo sapiens_hsa030102.02081133
11Fanconi anemia pathway_Homo sapiens_hsa034601.89738875
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.88236094
13Acute myeloid leukemia_Homo sapiens_hsa052211.83788566
14Non-small cell lung cancer_Homo sapiens_hsa052231.83527990
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80476876
16Graft-versus-host disease_Homo sapiens_hsa053321.74813711
17Hematopoietic cell lineage_Homo sapiens_hsa046401.74622915
18Asthma_Homo sapiens_hsa053101.71852334
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69471464
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57091541
21FoxO signaling pathway_Homo sapiens_hsa040681.56902696
22RNA degradation_Homo sapiens_hsa030181.56087746
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.51708050
24Thyroid cancer_Homo sapiens_hsa052161.48973432
25Nucleotide excision repair_Homo sapiens_hsa034201.46129821
26Homologous recombination_Homo sapiens_hsa034401.45780272
27Endometrial cancer_Homo sapiens_hsa052131.41253670
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32280035
29Chronic myeloid leukemia_Homo sapiens_hsa052201.31872281
30Spliceosome_Homo sapiens_hsa030401.31806809
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25619783
32Viral carcinogenesis_Homo sapiens_hsa052031.22310448
33Renal cell carcinoma_Homo sapiens_hsa052111.21433712
34Osteoclast differentiation_Homo sapiens_hsa043801.19428227
35Pancreatic cancer_Homo sapiens_hsa052121.18360174
36Prostate cancer_Homo sapiens_hsa052151.16906695
37mTOR signaling pathway_Homo sapiens_hsa041501.15042927
38VEGF signaling pathway_Homo sapiens_hsa043701.13951138
39HTLV-I infection_Homo sapiens_hsa051661.13329883
40Hepatitis B_Homo sapiens_hsa051611.10270872
41Colorectal cancer_Homo sapiens_hsa052101.09903598
42Mismatch repair_Homo sapiens_hsa034301.09670191
43Regulation of autophagy_Homo sapiens_hsa041401.08046993
44Type I diabetes mellitus_Homo sapiens_hsa049401.03405957
45RNA transport_Homo sapiens_hsa030131.01265739
46Apoptosis_Homo sapiens_hsa042101.01189524
47Circadian rhythm_Homo sapiens_hsa047100.97285081
48Herpes simplex infection_Homo sapiens_hsa051680.96268829
49DNA replication_Homo sapiens_hsa030300.95237485
50One carbon pool by folate_Homo sapiens_hsa006700.94015022
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93871631
52TNF signaling pathway_Homo sapiens_hsa046680.92577864
53Antigen processing and presentation_Homo sapiens_hsa046120.90863560
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88771244
55Insulin resistance_Homo sapiens_hsa049310.84096089
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79093549
57Basal transcription factors_Homo sapiens_hsa030220.78325189
58Epstein-Barr virus infection_Homo sapiens_hsa051690.78256417
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78151584
60Prolactin signaling pathway_Homo sapiens_hsa049170.77564969
61Long-term potentiation_Homo sapiens_hsa047200.76958512
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76566310
63MAPK signaling pathway_Homo sapiens_hsa040100.76504526
64Leishmaniasis_Homo sapiens_hsa051400.75989573
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74488935
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73543821
67Choline metabolism in cancer_Homo sapiens_hsa052310.69147745
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.67244568
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65954907
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.61547580
71Influenza A_Homo sapiens_hsa051640.61126090
72Type II diabetes mellitus_Homo sapiens_hsa049300.60344643
73Platelet activation_Homo sapiens_hsa046110.60222315
74Pyrimidine metabolism_Homo sapiens_hsa002400.58275803
75Malaria_Homo sapiens_hsa051440.57823318
76Chemokine signaling pathway_Homo sapiens_hsa040620.56481865
77Hepatitis C_Homo sapiens_hsa051600.56272329
78Viral myocarditis_Homo sapiens_hsa054160.55848206
79Systemic lupus erythematosus_Homo sapiens_hsa053220.54933370
80Basal cell carcinoma_Homo sapiens_hsa052170.54818649
81Non-homologous end-joining_Homo sapiens_hsa034500.54194318
82Toxoplasmosis_Homo sapiens_hsa051450.49814837
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47997517
84Insulin signaling pathway_Homo sapiens_hsa049100.47152189
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46117609
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.45655909
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44064134
88MicroRNAs in cancer_Homo sapiens_hsa052060.42835460
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42640460
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41161409
91mRNA surveillance pathway_Homo sapiens_hsa030150.39448277
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.38261898
93Notch signaling pathway_Homo sapiens_hsa043300.37496387
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37300075
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37070095
96Cell cycle_Homo sapiens_hsa041100.36865703
97Small cell lung cancer_Homo sapiens_hsa052220.35607293
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35365187
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34770385
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.34247525

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