ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.26595958
2	ATP synthesis coupled proton transport (GO:0015986)	6.26595958
3	viral transcription (GO:0019083)	6.23905230
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.14145064
5	ribosomal small subunit assembly (GO:0000028)	6.08641133
6	translational termination (GO:0006415)	5.96810261
7	maturation of SSU-rRNA (GO:0030490)	5.60235796
8	chaperone-mediated protein transport (GO:0072321)	5.37729111
9	translational elongation (GO:0006414)	5.32953039
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.19770344
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.16362927
12	cotranslational protein targeting to membrane (GO:0006613)	5.11738591
13	ribosomal small subunit biogenesis (GO:0042274)	5.11059236
14	protein targeting to ER (GO:0045047)	5.09530490
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.89660043
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.82959706
17	protein localization to endoplasmic reticulum (GO:0070972)	4.81372419
18	DNA deamination (GO:0045006)	4.75632509
19	respiratory electron transport chain (GO:0022904)	4.55639109
20	viral life cycle (GO:0019058)	4.52565151
21	electron transport chain (GO:0022900)	4.51219704
22	cellular protein complex disassembly (GO:0043624)	4.49393560
23	protein complex biogenesis (GO:0070271)	4.17069324
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.10323152
25	translational initiation (GO:0006413)	4.01937447
26	translation (GO:0006412)	3.95138374
27	protein neddylation (GO:0045116)	3.95121704
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.89443254
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.88544810
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.88544810
31	NADH dehydrogenase complex assembly (GO:0010257)	3.88544810
32	ATP biosynthetic process (GO:0006754)	3.69224415
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63406618
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63406618
35	protein complex disassembly (GO:0043241)	3.60140575
36	nucleotide salvage (GO:0043173)	3.50434298
37	hydrogen ion transmembrane transport (GO:1902600)	3.47764092
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.44181701
39	ribosomal large subunit biogenesis (GO:0042273)	3.41405692
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41330798
41	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.40448649
42	cytidine deamination (GO:0009972)	3.37560922
43	cytidine metabolic process (GO:0046087)	3.37560922
44	cytidine catabolic process (GO:0006216)	3.37560922
45	macromolecular complex disassembly (GO:0032984)	3.36586793
46	protein targeting to membrane (GO:0006612)	3.33901941
47	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.32427125
48	protein-cofactor linkage (GO:0018065)	3.28970131
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.24492248
50	behavioral response to nicotine (GO:0035095)	3.22595925
51	proton transport (GO:0015992)	3.21260770
52	respiratory chain complex IV assembly (GO:0008535)	3.21002070
53	regulation of activation of Janus kinase activity (GO:0010533)	3.19718818
54	hydrogen transport (GO:0006818)	3.14358382
55	cellular component biogenesis (GO:0044085)	3.13306142
56	cytochrome complex assembly (GO:0017004)	3.12059824
57	termination of RNA polymerase III transcription (GO:0006386)	3.07573777
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07573777
59	negative regulation of mast cell activation (GO:0033004)	3.01404468
60	ribonucleoprotein complex biogenesis (GO:0022613)	2.97818948
61	pseudouridine synthesis (GO:0001522)	2.96501644
62	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.95535144
63	CTP biosynthetic process (GO:0006241)	2.94448045
64	CTP metabolic process (GO:0046036)	2.94448045
65	nucleoside triphosphate biosynthetic process (GO:0009142)	2.92189575
66	glyoxylate metabolic process (GO:0046487)	2.91843991
67	neurofilament cytoskeleton organization (GO:0060052)	2.91125184
68	nucleoside salvage (GO:0043174)	2.89945224
69	purine nucleotide salvage (GO:0032261)	2.86363041
70	proteasome assembly (GO:0043248)	2.85946099
71	intracellular protein transmembrane import (GO:0044743)	2.79749817
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79463132
73	protein targeting to mitochondrion (GO:0006626)	2.78624807
74	mRNA catabolic process (GO:0006402)	2.75385885
75	negative regulation of T cell differentiation in thymus (GO:0033085)	2.68009590
76	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.66612725
77	S-adenosylmethionine metabolic process (GO:0046500)	2.66572007
78	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.64754500
79	establishment of protein localization to mitochondrion (GO:0072655)	2.64187083
80	rRNA processing (GO:0006364)	2.61839318
81	regulation of cellular amino acid metabolic process (GO:0006521)	2.60354036
82	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.59269056
83	rRNA metabolic process (GO:0016072)	2.58610392
84	negative regulation of telomere maintenance (GO:0032205)	2.55214280
85	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.54743957
86	GTP biosynthetic process (GO:0006183)	2.53001011
87	regulation of isotype switching to IgG isotypes (GO:0048302)	2.50776868
88	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.50607939
89	dopamine transport (GO:0015872)	2.49964745
90	RNA catabolic process (GO:0006401)	2.49900152
91	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.49691157
92	UMP metabolic process (GO:0046049)	2.49691157
93	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.49691157
94	UMP biosynthetic process (GO:0006222)	2.49691157
95	regulation of cellular respiration (GO:0043457)	2.49619591
96	protein localization to mitochondrion (GO:0070585)	2.48933130
97	tRNA processing (GO:0008033)	2.47415708
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.45129608
99	mast cell activation (GO:0045576)	2.41758491
100	ubiquinone biosynthetic process (GO:0006744)	2.41037186

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.82920156
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.02705782
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.64260337
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.57209872
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.55704339
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.21627522
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09902205
8	VDR_22108803_ChIP-Seq_LS180_Human	2.78994594
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68506752
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64233992
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63006139
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62719050
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.33678679
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16450640
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14266539
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.13108126
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.12584003
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.04498268
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04423574
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.02244295
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95881555
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.90060208
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.85899924
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.76825478
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73454658
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.66080984
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64278497
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58106822
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.56010790
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46750660
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.46231393
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.42546975
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.41451058
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41225937
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38389534
36	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.37211898
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.30260145
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29682078
39	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28033947
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24666474
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24349332
42	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24109815
43	GATA3_26560356_Chip-Seq_TH2_Human	1.23601923
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22884578
45	AR_20517297_ChIP-Seq_VCAP_Human	1.22694289
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21883116
47	EWS_26573619_Chip-Seq_HEK293_Human	1.21406505
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19423578
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18970149
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18786240
51	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16333189
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15688609
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15055371
54	NCOR_22424771_ChIP-Seq_293T_Human	1.14253763
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14209866
56	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13228952
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12594820
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12338124
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11737274
60	ERA_21632823_ChIP-Seq_H3396_Human	1.08855554
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08207159
62	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07573936
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06369587
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05067404
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05067404
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.04195846
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03565935
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02895232
69	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.02671956
70	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02365719
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01547671
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01547650
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.01286588
74	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01276235
75	XRN2_22483619_ChIP-Seq_HELA_Human	1.00355548
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99610921
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99202870
78	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98937552
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94051440
80	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93970132
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93830224
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93256898
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92681351
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92120895
85	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91677232
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90461699
87	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89986807
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89180684
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89180684
90	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.88229327
91	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86502707
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.86494522
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86249222
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.85843146
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85251475
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84767951
97	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.84736166
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.84173224
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.84142372
100	STAT1_20625510_ChIP-Seq_HELA_Human	0.83947108

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.21705780
2	MP0001835_abnormal_antigen_presentation	3.13765280
3	MP0009379_abnormal_foot_pigmentation	2.97137134
4	MP0008875_abnormal_xenobiotic_pharmacok	2.64540667
5	MP0006292_abnormal_olfactory_placode	2.60736802
6	MP0003646_muscle_fatigue	2.56583562
7	MP0008995_early_reproductive_senescence	2.47627416
8	MP0003806_abnormal_nucleotide_metabolis	2.31203456
9	MP0005646_abnormal_pituitary_gland	2.18896702
10	MP0008872_abnormal_physiological_respon	2.18632487
11	MP0009785_altered_susceptibility_to	2.09762771
12	MP0004145_abnormal_muscle_electrophysio	2.09682579
13	MP0002163_abnormal_gland_morphology	2.08275081
14	MP0004885_abnormal_endolymph	1.99268765
15	MP0002837_dystrophic_cardiac_calcinosis	1.98873024
16	MP0004147_increased_porphyrin_level	1.92902533
17	MP0002876_abnormal_thyroid_physiology	1.92160196
18	MP0001905_abnormal_dopamine_level	1.83887289
19	MP0009333_abnormal_splenocyte_physiolog	1.78673727
20	MP0001800_abnormal_humoral_immune	1.70405285
21	MP0006072_abnormal_retinal_apoptosis	1.70011324
22	MP0001986_abnormal_taste_sensitivity	1.66670484
23	MP0003195_calcinosis	1.66616097
24	MP0002638_abnormal_pupillary_reflex	1.65040827
25	MP0006082_CNS_inflammation	1.64095526
26	MP0005000_abnormal_immune_tolerance	1.63043901
27	MP0003786_premature_aging	1.61806897
28	MP0002138_abnormal_hepatobiliary_system	1.59496090
29	MP0002102_abnormal_ear_morphology	1.54109327
30	MP0002277_abnormal_respiratory_mucosa	1.51233639
31	MP0002148_abnormal_hypersensitivity_rea	1.50942918
32	MP0004142_abnormal_muscle_tone	1.50905944
33	MP0001968_abnormal_touch/_nociception	1.46343401
34	MP0002736_abnormal_nociception_after	1.46034092
35	MP0002723_abnormal_immune_serum	1.44193860
36	MP0006036_abnormal_mitochondrial_physio	1.44168297
37	MP0000372_irregular_coat_pigmentation	1.43423898
38	MP0005551_abnormal_eye_electrophysiolog	1.41301850
39	MP0003763_abnormal_thymus_physiology	1.39378623
40	MP0005645_abnormal_hypothalamus_physiol	1.39348448
41	MP0001529_abnormal_vocalization	1.37787930
42	MP0005084_abnormal_gallbladder_morpholo	1.34930740
43	MP0002420_abnormal_adaptive_immunity	1.34474458
44	MP0003878_abnormal_ear_physiology	1.32992412
45	MP0005377_hearing/vestibular/ear_phenot	1.32992412
46	MP0001873_stomach_inflammation	1.32118166
47	MP0001819_abnormal_immune_cell	1.30252593
48	MP0005379_endocrine/exocrine_gland_phen	1.29105812
49	MP0002653_abnormal_ependyma_morphology	1.28145512
50	MP0003186_abnormal_redox_activity	1.28038799
51	MP0001790_abnormal_immune_system	1.27934444
52	MP0005387_immune_system_phenotype	1.27934444
53	MP0000685_abnormal_immune_system	1.25022370
54	MP0005025_abnormal_response_to	1.24602487
55	MP0009745_abnormal_behavioral_response	1.23620421
56	MP0002452_abnormal_antigen_presenting	1.21164306
57	MP0002272_abnormal_nervous_system	1.12905683
58	MP0005389_reproductive_system_phenotype	1.09162818
59	MP0003011_delayed_dark_adaptation	1.08775340
60	MP0001919_abnormal_reproductive_system	1.07036329
61	MP0001485_abnormal_pinna_reflex	1.06590305
62	MP0005360_urolithiasis	1.05924728
63	MP0001764_abnormal_homeostasis	1.05604625
64	MP0000716_abnormal_immune_system	1.02280860
65	MP0010155_abnormal_intestine_physiology	1.01909878
66	MP0002160_abnormal_reproductive_system	1.01807922
67	MP0001348_abnormal_lacrimal_gland	1.01394122
68	MP0006276_abnormal_autonomic_nervous	0.99204362
69	MP0009046_muscle_twitch	0.97856859
70	MP0005075_abnormal_melanosome_morpholog	0.97464538
71	MP0005253_abnormal_eye_physiology	0.96358812
72	MP0003866_abnormal_defecation	0.95996210
73	MP0002398_abnormal_bone_marrow	0.95131323
74	MP0002933_joint_inflammation	0.94245023
75	MP0003724_increased_susceptibility_to	0.94092421
76	MP0008775_abnormal_heart_ventricle	0.93964236
77	MP0004742_abnormal_vestibular_system	0.91868454
78	MP0001845_abnormal_inflammatory_respons	0.90913040
79	MP0005636_abnormal_mineral_homeostasis	0.90904627
80	MP0003567_abnormal_fetal_cardiomyocyte	0.89338688
81	MP0002095_abnormal_skin_pigmentation	0.89244145
82	MP0002234_abnormal_pharynx_morphology	0.83825665
83	MP0003136_yellow_coat_color	0.82380860
84	MP0005410_abnormal_fertilization	0.82220036
85	MP0002429_abnormal_blood_cell	0.81543028
86	MP0000631_abnormal_neuroendocrine_gland	0.81180725
87	MP0001440_abnormal_grooming_behavior	0.79603116
88	MP0002735_abnormal_chemical_nociception	0.78302287
89	MP0001970_abnormal_pain_threshold	0.78285331
90	MP0000049_abnormal_middle_ear	0.78129453
91	MP0005085_abnormal_gallbladder_physiolo	0.76857931
92	MP0001984_abnormal_olfaction	0.76156612
93	MP0002693_abnormal_pancreas_physiology	0.75825061
94	MP0005332_abnormal_amino_acid	0.75567748
95	MP0002733_abnormal_thermal_nociception	0.73937015
96	MP0000689_abnormal_spleen_morphology	0.73857193
97	MP0000703_abnormal_thymus_morphology	0.73538097
98	MP0002132_abnormal_respiratory_system	0.73020678
99	MP0002166_altered_tumor_susceptibility	0.70829880
100	MP0001663_abnormal_digestive_system	0.70031737

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.04806873
2	Mitochondrial inheritance (HP:0001427)	4.60584420
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.50549756
4	Increased hepatocellular lipid droplets (HP:0006565)	4.49463271
5	Progressive macrocephaly (HP:0004481)	4.25800802
6	Increased CSF lactate (HP:0002490)	4.20550885
7	Acute encephalopathy (HP:0006846)	4.17679754
8	Lipid accumulation in hepatocytes (HP:0006561)	4.11947422
9	Renal Fanconi syndrome (HP:0001994)	3.97377221
10	Aplastic anemia (HP:0001915)	3.91541410
11	Reticulocytopenia (HP:0001896)	3.70559919
12	3-Methylglutaconic aciduria (HP:0003535)	3.65452423
13	Exertional dyspnea (HP:0002875)	3.52874986
14	Increased intramyocellular lipid droplets (HP:0012240)	3.52274560
15	Abnormal number of erythroid precursors (HP:0012131)	3.43167523
16	Hepatocellular necrosis (HP:0001404)	3.38158300
17	Congenital stationary night blindness (HP:0007642)	3.35763324
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.32595165
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.26776544
20	Cerebral edema (HP:0002181)	3.13748174
21	Hepatic necrosis (HP:0002605)	3.04761760
22	Increased muscle lipid content (HP:0009058)	2.96510830
23	Congenital, generalized hypertrichosis (HP:0004540)	2.89953970
24	Increased serum lactate (HP:0002151)	2.87467590
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84816807
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84816807
27	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.79583371
28	Abnormality of B cell number (HP:0010975)	2.77631794
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.75633914
30	Pancreatic cysts (HP:0001737)	2.71634514
31	Hypoproteinemia (HP:0003075)	2.69157046
32	Optic disc pallor (HP:0000543)	2.69133376
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.61296746
34	Lactic acidosis (HP:0003128)	2.57731061
35	Macrocytic anemia (HP:0001972)	2.56546388
36	IgG deficiency (HP:0004315)	2.54784718
37	Pallor (HP:0000980)	2.54395802
38	Oral leukoplakia (HP:0002745)	2.52168459
39	Abnormality of T cell number (HP:0011839)	2.47791889
40	Increased IgM level (HP:0003496)	2.41325892
41	Chronic otitis media (HP:0000389)	2.40636082
42	Abnormality of renal resorption (HP:0011038)	2.38716421
43	Abnormality of the renal collecting system (HP:0004742)	2.37376556
44	Chronic sinusitis (HP:0011109)	2.37075937
45	Molar tooth sign on MRI (HP:0002419)	2.36830146
46	Abnormality of midbrain morphology (HP:0002418)	2.36830146
47	Respiratory difficulties (HP:0002880)	2.32880976
48	Respiratory failure (HP:0002878)	2.32457785
49	Pancreatic fibrosis (HP:0100732)	2.30908177
50	Absent thumb (HP:0009777)	2.28586930
51	Eosinophilia (HP:0001880)	2.26863008
52	Glycosuria (HP:0003076)	2.25654973
53	Abnormality of urine glucose concentration (HP:0011016)	2.25654973
54	Pancytopenia (HP:0001876)	2.24025230
55	Autoimmune hemolytic anemia (HP:0001890)	2.23754242
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.23518734
57	Abnormality of eosinophils (HP:0001879)	2.20057215
58	Exercise intolerance (HP:0003546)	2.14824033
59	Attenuation of retinal blood vessels (HP:0007843)	2.14420062
60	Duplicated collecting system (HP:0000081)	2.13925867
61	Abnormality of the renal cortex (HP:0011035)	2.13680813
62	Hypoplasia of the uterus (HP:0000013)	2.13453824
63	Leukodystrophy (HP:0002415)	2.12520741
64	Hyperphosphaturia (HP:0003109)	2.11898186
65	Severe combined immunodeficiency (HP:0004430)	2.09494308
66	Abnormality of T cells (HP:0002843)	2.08842496
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.07578553
68	Absent/shortened dynein arms (HP:0200106)	2.07578553
69	Lethargy (HP:0001254)	2.07541375
70	Autoimmune thrombocytopenia (HP:0001973)	2.05731429
71	True hermaphroditism (HP:0010459)	2.05120825
72	T lymphocytopenia (HP:0005403)	2.04237148
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99172449
74	Hypothermia (HP:0002045)	1.96700279
75	Renal cortical cysts (HP:0000803)	1.94341773
76	Abnormal hemoglobin (HP:0011902)	1.92863485
77	Polydipsia (HP:0001959)	1.92050663
78	Abnormal drinking behavior (HP:0030082)	1.92050663
79	Elevated erythrocyte sedimentation rate (HP:0003565)	1.91249385
80	Thyroiditis (HP:0100646)	1.90414466
81	Stomatitis (HP:0010280)	1.90107188
82	Pendular nystagmus (HP:0012043)	1.89476980
83	Abolished electroretinogram (ERG) (HP:0000550)	1.88878769
84	B lymphocytopenia (HP:0010976)	1.87108630
85	Hypomagnesemia (HP:0002917)	1.82556582
86	Thyroid-stimulating hormone excess (HP:0002925)	1.81479718
87	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.81451341
88	Generalized aminoaciduria (HP:0002909)	1.80371822
89	Constricted visual fields (HP:0001133)	1.79048016
90	Abnormality of DNA repair (HP:0003254)	1.78676923
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.77867261
92	Decreased central vision (HP:0007663)	1.77081740
93	Abnormality of magnesium homeostasis (HP:0004921)	1.76988050
94	Nasal polyposis (HP:0100582)	1.76041378
95	Abnormality of the ileum (HP:0001549)	1.75701184
96	Meckel diverticulum (HP:0002245)	1.73617466
97	Stomach cancer (HP:0012126)	1.73166607
98	Polyuria (HP:0000103)	1.73040673
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69219240
100	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.69037634

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.11109376
2	TXK	5.68550044
3	MAP4K1	4.43837957
4	TLK1	3.17609588
5	ZAK	2.64426506
6	BCKDK	2.51713409
7	KDR	2.28471331
8	MAP4K2	2.25447426
9	ADRBK2	2.21932637
10	GRK1	1.97188067
11	PASK	1.80572681
12	LIMK1	1.69967534
13	PINK1	1.69819540
14	NME2	1.53542571
15	MAP3K13	1.45850902
16	VRK2	1.42468705
17	FRK	1.39481143
18	CDK19	1.31560933
19	OXSR1	1.31067322
20	MAP3K12	1.30509640
21	STK16	1.27956516
22	TAOK2	1.26317705
23	FES	1.25683374
24	NUAK1	1.24209525
25	DYRK2	1.19578825
26	TESK2	1.18543364
27	TIE1	1.15645142
28	BMPR1B	1.13551536
29	ITK	1.12566592
30	WNK4	1.12357210
31	IKBKB	1.08921200
32	BUB1	1.05056536
33	RPS6KA5	1.04738673
34	VRK1	1.02826916
35	TEC	0.99286815
36	TESK1	0.98597602
37	MYLK	0.95735480
38	INSRR	0.94707721
39	SYK	0.94625653
40	PRKCQ	0.92421983
41	WNK3	0.88124587
42	BMPR2	0.88108497
43	MST4	0.87855368
44	BTK	0.86449545
45	CDK8	0.84777423
46	LYN	0.81891019
47	ILK	0.81251239
48	LCK	0.81212395
49	MUSK	0.80000252
50	OBSCN	0.77010102
51	NME1	0.71893428
52	KIT	0.71833590
53	TNK2	0.71566171
54	CAMKK2	0.70740781
55	CAMKK1	0.67789328
56	ADRBK1	0.67704054
57	ZAP70	0.66759825
58	PHKG2	0.66267956
59	PHKG1	0.66267956
60	CSF1R	0.65974967
61	PDK2	0.64183948
62	MAPK13	0.62925771
63	PRKCG	0.62412246
64	IKBKE	0.60006592
65	PRPF4B	0.56781171
66	GRK7	0.56762452
67	GRK6	0.55683984
68	MAP2K6	0.53775951
69	MAPKAPK3	0.53440469
70	CSNK2A2	0.53412814
71	PIK3CG	0.53163535
72	EIF2AK1	0.51780152
73	CSNK2A1	0.51265403
74	DAPK1	0.49400038
75	PRKCH	0.49390456
76	EIF2AK3	0.47707877
77	ABL2	0.47372302
78	IGF1R	0.47221527
79	CSNK1G1	0.45649768
80	TSSK6	0.44519107
81	PKN1	0.44335166
82	PRKCA	0.42593235
83	STK39	0.42292260
84	SRPK1	0.41160752
85	PIK3CA	0.39945388
86	CSNK1A1	0.39193124
87	PRKACA	0.38751864
88	LRRK2	0.38360498
89	DAPK3	0.38351772
90	MAPK15	0.37014694
91	PBK	0.36893916
92	TYRO3	0.33446734
93	ATR	0.33150915
94	PLK4	0.32065828
95	JAK3	0.31888557
96	NLK	0.31220211
97	PIM1	0.30491970
98	HCK	0.27711867
99	MAP3K14	0.27359776
100	PRKCD	0.27041627

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.12504380
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.10621446
3	Parkinsons disease_Homo sapiens_hsa05012	3.47125528
4	Proteasome_Homo sapiens_hsa03050	3.33024129
5	Allograft rejection_Homo sapiens_hsa05330	2.72595708
6	Asthma_Homo sapiens_hsa05310	2.72589599
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.64897171
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.50196814
9	RNA polymerase_Homo sapiens_hsa03020	2.42528962
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.33939415
11	Alzheimers disease_Homo sapiens_hsa05010	2.19789344
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.17499564
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14398846
14	Huntingtons disease_Homo sapiens_hsa05016	2.11773345
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.08760715
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90208706
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.74644652
18	Protein export_Homo sapiens_hsa03060	1.57189838
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54620394
20	Sulfur relay system_Homo sapiens_hsa04122	1.54166322
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42701024
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42051497
23	Phototransduction_Homo sapiens_hsa04744	1.40024172
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.37863598
25	Caffeine metabolism_Homo sapiens_hsa00232	1.35058734
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29515998
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28312494
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.27598072
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24192427
30	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.19884645
31	Homologous recombination_Homo sapiens_hsa03440	1.19563738
32	One carbon pool by folate_Homo sapiens_hsa00670	1.18090183
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17560373
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.17027171
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13438449
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11132530
37	RNA degradation_Homo sapiens_hsa03018	1.03044638
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.97424724
39	Viral myocarditis_Homo sapiens_hsa05416	0.96230580
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96139215
41	DNA replication_Homo sapiens_hsa03030	0.93804662
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93211257
43	Purine metabolism_Homo sapiens_hsa00230	0.90808621
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90744053
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.90732646
46	Basal transcription factors_Homo sapiens_hsa03022	0.87453521
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87371940
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85376034
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84074898
50	Mismatch repair_Homo sapiens_hsa03430	0.83703492
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83109379
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83069282
53	Sulfur metabolism_Homo sapiens_hsa00920	0.76574522
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74910602
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73768343
56	Spliceosome_Homo sapiens_hsa03040	0.73330040
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72956471
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70492446
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.69944522
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69306231
61	Olfactory transduction_Homo sapiens_hsa04740	0.68031331
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66546099
63	Retinol metabolism_Homo sapiens_hsa00830	0.66498733
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64220889
65	Malaria_Homo sapiens_hsa05144	0.63449058
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63356354
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62444358
68	Metabolic pathways_Homo sapiens_hsa01100	0.61472997
69	Leishmaniasis_Homo sapiens_hsa05140	0.61187134
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60732609
71	Butanoate metabolism_Homo sapiens_hsa00650	0.60415659
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59236006
73	Peroxisome_Homo sapiens_hsa04146	0.59211493
74	Nicotine addiction_Homo sapiens_hsa05033	0.57825782
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55558093
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.55452281
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54942778
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51971206
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.50616669
80	Propanoate metabolism_Homo sapiens_hsa00640	0.47462233
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.46610553
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46476353
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45231937
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42533197
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42408667
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.40669207
87	Base excision repair_Homo sapiens_hsa03410	0.40342733
88	Measles_Homo sapiens_hsa05162	0.39053523
89	RNA transport_Homo sapiens_hsa03013	0.38807576
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38320535
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34994081
92	Taste transduction_Homo sapiens_hsa04742	0.33175943
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32637257
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30771651
95	Regulation of autophagy_Homo sapiens_hsa04140	0.26537543
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24560409
97	Morphine addiction_Homo sapiens_hsa05032	0.19206017
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.17809267
99	Herpes simplex infection_Homo sapiens_hsa05168	0.17263746
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.16508351

RPL23AP65

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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