ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	5.14624675
2	behavioral response to nicotine (GO:0035095)	5.05942675
3	negative regulation of multicellular organism growth (GO:0040015)	4.66059285
4	interkinetic nuclear migration (GO:0022027)	4.34881290
5	cellular ketone body metabolic process (GO:0046950)	4.26701178
6	neural tube formation (GO:0001841)	4.21936943
7	behavioral response to ethanol (GO:0048149)	4.08858915
8	indole-containing compound catabolic process (GO:0042436)	4.05144011
9	indolalkylamine catabolic process (GO:0046218)	4.05144011
10	tryptophan catabolic process (GO:0006569)	4.05144011
11	regulation of MHC class I biosynthetic process (GO:0045343)	4.00532250
12	sex differentiation (GO:0007548)	3.98102069
13	kynurenine metabolic process (GO:0070189)	3.95288936
14	indolalkylamine metabolic process (GO:0006586)	3.81190817
15	ketone body metabolic process (GO:1902224)	3.72899907
16	positive regulation of meiosis (GO:0045836)	3.62601876
17	ADP metabolic process (GO:0046031)	3.60567885
18	DNA deamination (GO:0045006)	3.51898471
19	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.50375733
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.50141606
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.49718043
22	synaptic transmission, cholinergic (GO:0007271)	3.46987858
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43216956
24	rRNA catabolic process (GO:0016075)	3.42667032
25	L-methionine salvage (GO:0071267)	3.42218661
26	L-methionine biosynthetic process (GO:0071265)	3.42218661
27	amino acid salvage (GO:0043102)	3.42218661
28	regulation of female receptivity (GO:0045924)	3.40146829
29	kidney morphogenesis (GO:0060993)	3.38244043
30	positive regulation of meiotic cell cycle (GO:0051446)	3.36269597
31	adaptation of signaling pathway (GO:0023058)	3.35790820
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.33652391
33	detection of light stimulus involved in visual perception (GO:0050908)	3.33652391
34	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.28593449
35	tryptophan metabolic process (GO:0006568)	3.17685218
36	axoneme assembly (GO:0035082)	3.17020299
37	regulation of meiosis I (GO:0060631)	3.17012772
38	fucose catabolic process (GO:0019317)	3.15793901
39	L-fucose metabolic process (GO:0042354)	3.15793901
40	L-fucose catabolic process (GO:0042355)	3.15793901
41	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.13805589
42	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.13805589
43	regulation of translation, ncRNA-mediated (GO:0045974)	3.13805589
44	cornea development in camera-type eye (GO:0061303)	3.13695748
45	ubiquinone biosynthetic process (GO:0006744)	3.12181748
46	auditory receptor cell stereocilium organization (GO:0060088)	3.11304923
47	cholesterol catabolic process (GO:0006707)	3.09264941
48	sterol catabolic process (GO:0016127)	3.09264941
49	somite development (GO:0061053)	3.08400425
50	epithelial cilium movement (GO:0003351)	3.03583372
51	phosphatidylethanolamine metabolic process (GO:0046337)	3.03295622
52	protein polyglutamylation (GO:0018095)	3.02928292
53	regulation of establishment of cell polarity (GO:2000114)	3.02476436
54	photoreceptor cell maintenance (GO:0045494)	3.01773978
55	ubiquinone metabolic process (GO:0006743)	3.01296064
56	negative regulation of mast cell activation (GO:0033004)	2.98186611
57	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.97492412
58	pyrimidine nucleobase catabolic process (GO:0006208)	2.96018246
59	synapsis (GO:0007129)	2.95735075
60	regulation of action potential (GO:0098900)	2.95700791
61	parental behavior (GO:0060746)	2.93744643
62	cytoplasmic mRNA processing body assembly (GO:0033962)	2.89437397
63	reciprocal meiotic recombination (GO:0007131)	2.88785128
64	reciprocal DNA recombination (GO:0035825)	2.88785128
65	cilium morphogenesis (GO:0060271)	2.87827942
66	nucleobase catabolic process (GO:0046113)	2.85258444
67	piRNA metabolic process (GO:0034587)	2.85044558
68	somite rostral/caudal axis specification (GO:0032525)	2.83782439
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.81352709
70	aggressive behavior (GO:0002118)	2.80398635
71	proline transport (GO:0015824)	2.79996262
72	limb bud formation (GO:0060174)	2.79882881
73	GPI anchor metabolic process (GO:0006505)	2.79416828
74	female mating behavior (GO:0060180)	2.79341665
75	water-soluble vitamin biosynthetic process (GO:0042364)	2.77778107
76	regulation of mesoderm development (GO:2000380)	2.77046565
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76682273
78	maternal behavior (GO:0042711)	2.73291382
79	NAD biosynthetic process (GO:0009435)	2.73125419
80	regulation of pigment cell differentiation (GO:0050932)	2.71653607
81	DNA demethylation (GO:0080111)	2.69623512
82	embryonic epithelial tube formation (GO:0001838)	2.69156083
83	negative regulation of leukocyte chemotaxis (GO:0002689)	2.69080350
84	gamma-aminobutyric acid transport (GO:0015812)	2.66451128
85	cilium movement (GO:0003341)	2.65887416
86	DNA methylation involved in gamete generation (GO:0043046)	2.65540521
87	protein localization to cilium (GO:0061512)	2.63971419
88	iron-sulfur cluster assembly (GO:0016226)	2.63455948
89	metallo-sulfur cluster assembly (GO:0031163)	2.63455948
90	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.62893926
91	indole-containing compound metabolic process (GO:0042430)	2.62822824
92	nonmotile primary cilium assembly (GO:0035058)	2.61017310
93	central nervous system projection neuron axonogenesis (GO:0021952)	2.59914263
94	ovulation cycle (GO:0042698)	2.59258565
95	aromatic amino acid family catabolic process (GO:0009074)	2.58892580
96	cell proliferation in forebrain (GO:0021846)	2.58429626
97	head development (GO:0060322)	2.58138731
98	tachykinin receptor signaling pathway (GO:0007217)	2.53557098
99	positive regulation of fatty acid oxidation (GO:0046321)	2.53011811
100	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52259524

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.55178049
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51138650
3	VDR_22108803_ChIP-Seq_LS180_Human	3.46246584
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75834253
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.65370580
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60679058
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.60266567
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57586490
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43451289
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28792625
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.20679603
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14630329
13	FUS_26573619_Chip-Seq_HEK293_Human	1.97716333
14	BCAT_22108803_ChIP-Seq_LS180_Human	1.96840662
15	P300_19829295_ChIP-Seq_ESCs_Human	1.96503325
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91900348
17	EWS_26573619_Chip-Seq_HEK293_Human	1.86609484
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86440428
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73843621
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.72340585
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72196642
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72122915
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71780775
24	STAT3_23295773_ChIP-Seq_U87_Human	1.70351688
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68231202
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66861987
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.66542608
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66539614
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64095192
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.63073182
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62606677
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60610498
33	AR_25329375_ChIP-Seq_VCAP_Human	1.59367325
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56008900
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52518347
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.52381603
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52381603
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49722651
39	TCF4_23295773_ChIP-Seq_U87_Human	1.49339933
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49036550
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.47204606
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.46566461
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44017341
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43046046
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.41927579
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38998761
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37195507
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35976109
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34653291
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32733279
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30868050
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29514347
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29136006
54	DROSHA_22980978_ChIP-Seq_HELA_Human	1.27287779
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24780468
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24780468
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.23940982
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23721320
59	KDM2B_26808549_Chip-Seq_REH_Human	1.22902285
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22187691
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21262650
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21262650
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19584885
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19368429
65	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17312698
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.16584970
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16470910
68	NCOR_22424771_ChIP-Seq_293T_Human	1.15688046
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14909886
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14702903
71	AR_20517297_ChIP-Seq_VCAP_Human	1.13861889
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12898114
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12898114
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12878042
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11885843
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11280075
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10853447
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10527075
79	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10520773
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10242434
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.09722880
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09259998
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07995689
84	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07277251
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07129600
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07104048
87	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.06706551
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05027144
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03569094
90	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02442106
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02120585
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01918493
93	JUN_21703547_ChIP-Seq_K562_Human	1.01339807
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00878609
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00847986
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00678364
97	RXR_22108803_ChIP-Seq_LS180_Human	0.99859974
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.99645372
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98333008
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.97746511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.58309928
2	MP0002653_abnormal_ependyma_morphology	2.97337044
3	MP0005646_abnormal_pituitary_gland	2.88056243
4	MP0003646_muscle_fatigue	2.79592025
5	MP0001968_abnormal_touch/_nociception	2.75190719
6	MP0003011_delayed_dark_adaptation	2.63360113
7	MP0001501_abnormal_sleep_pattern	2.46141592
8	MP0002234_abnormal_pharynx_morphology	2.38892420
9	MP0005551_abnormal_eye_electrophysiolog	2.34998479
10	MP0002102_abnormal_ear_morphology	2.33851064
11	MP0002876_abnormal_thyroid_physiology	2.28004324
12	MP0003880_abnormal_central_pattern	2.25396258
13	MP0000569_abnormal_digit_pigmentation	2.11937396
14	MP0001986_abnormal_taste_sensitivity	2.08658315
15	MP0003252_abnormal_bile_duct	2.06265017
16	MP0005253_abnormal_eye_physiology	2.05745679
17	MP0006072_abnormal_retinal_apoptosis	2.05457605
18	MP0003787_abnormal_imprinting	2.04192817
19	MP0002736_abnormal_nociception_after	2.02434603
20	MP0000427_abnormal_hair_cycle	1.97687892
21	MP0004885_abnormal_endolymph	1.96137925
22	MP0008877_abnormal_DNA_methylation	1.90456880
23	MP0002837_dystrophic_cardiac_calcinosis	1.89198043
24	MP0009745_abnormal_behavioral_response	1.86836670
25	MP0005084_abnormal_gallbladder_morpholo	1.83754078
26	MP0010386_abnormal_urinary_bladder	1.80547174
27	MP0002282_abnormal_trachea_morphology	1.80497824
28	MP0000631_abnormal_neuroendocrine_gland	1.80307508
29	MP0003195_calcinosis	1.74666972
30	MP0002928_abnormal_bile_duct	1.66756479
31	MP0005174_abnormal_tail_pigmentation	1.60081698
32	MP0005645_abnormal_hypothalamus_physiol	1.57769239
33	MP0000383_abnormal_hair_follicle	1.49799109
34	MP0001764_abnormal_homeostasis	1.47542090
35	MP0002163_abnormal_gland_morphology	1.44135629
36	MP0004133_heterotaxia	1.41845186
37	MP0005085_abnormal_gallbladder_physiolo	1.40370610
38	MP0004043_abnormal_pH_regulation	1.38464521
39	MP0010368_abnormal_lymphatic_system	1.33964512
40	MP0002272_abnormal_nervous_system	1.32626452
41	MP0005167_abnormal_blood-brain_barrier	1.31952991
42	MP0001188_hyperpigmentation	1.30891773
43	MP0009764_decreased_sensitivity_to	1.29514655
44	MP0001486_abnormal_startle_reflex	1.23776154
45	MP0008872_abnormal_physiological_respon	1.22300551
46	MP0004145_abnormal_muscle_electrophysio	1.20900963
47	MP0009697_abnormal_copulation	1.18156011
48	MP0002572_abnormal_emotion/affect_behav	1.15830189
49	MP0006276_abnormal_autonomic_nervous	1.11853413
50	MP0000026_abnormal_inner_ear	1.11243291
51	MP0001970_abnormal_pain_threshold	1.11214918
52	MP0005647_abnormal_sex_gland	1.08564478
53	MP0002254_reproductive_system_inflammat	1.06521237
54	MP0000049_abnormal_middle_ear	1.06470118
55	MP0001984_abnormal_olfaction	1.06436839
56	MP0003119_abnormal_digestive_system	1.06189692
57	MP0003718_maternal_effect	1.05648871
58	MP0002733_abnormal_thermal_nociception	1.05235940
59	MP0004130_abnormal_muscle_cell	1.03208099
60	MP0008875_abnormal_xenobiotic_pharmacok	1.02760557
61	MP0003635_abnormal_synaptic_transmissio	0.98995427
62	MP0008789_abnormal_olfactory_epithelium	0.98553770
63	MP0002160_abnormal_reproductive_system	0.97945109
64	MP0000681_abnormal_thyroid_gland	0.96747295
65	MP0002064_seizures	0.96091917
66	MP0001963_abnormal_hearing_physiology	0.94407255
67	MP0005389_reproductive_system_phenotype	0.91929165
68	MP0000230_abnormal_systemic_arterial	0.91879703
69	MP0002138_abnormal_hepatobiliary_system	0.90154419
70	MP0002938_white_spotting	0.89908643
71	MP0004147_increased_porphyrin_level	0.89137520
72	MP0005195_abnormal_posterior_eye	0.88782508
73	MP0001485_abnormal_pinna_reflex	0.88346266
74	MP0009046_muscle_twitch	0.88307545
75	MP0005310_abnormal_salivary_gland	0.86757160
76	MP0003137_abnormal_impulse_conducting	0.85684693
77	MP0000372_irregular_coat_pigmentation	0.85677570
78	MP0005379_endocrine/exocrine_gland_phen	0.85130106
79	MP0002751_abnormal_autonomic_nervous	0.84569156
80	MP0008058_abnormal_DNA_repair	0.84300988
81	MP0002752_abnormal_somatic_nervous	0.82407736
82	MP0006054_spinal_hemorrhage	0.81645912
83	MP0003938_abnormal_ear_development	0.81173861
84	MP0002063_abnormal_learning/memory/cond	0.80848512
85	MP0003698_abnormal_male_reproductive	0.80841019
86	MP0002735_abnormal_chemical_nociception	0.80759933
87	MP0000470_abnormal_stomach_morphology	0.80331624
88	MP0002557_abnormal_social/conspecific_i	0.79638172
89	MP0000015_abnormal_ear_pigmentation	0.75968507
90	MP0003315_abnormal_perineum_morphology	0.75248805
91	MP0002009_preneoplasia	0.75208447
92	MP0003283_abnormal_digestive_organ	0.74989579
93	MP0005410_abnormal_fertilization	0.74452922
94	MP0002734_abnormal_mechanical_nocicepti	0.74170127
95	MP0001119_abnormal_female_reproductive	0.72865280
96	MP0005423_abnormal_somatic_nervous	0.71099332
97	MP0004215_abnormal_myocardial_fiber	0.70812975
98	MP0002095_abnormal_skin_pigmentation	0.69879828
99	MP0009379_abnormal_foot_pigmentation	0.68585752
100	MP0004134_abnormal_chest_morphology	0.67254770

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.86407200
2	Pancreatic cysts (HP:0001737)	4.37736463
3	Progressive cerebellar ataxia (HP:0002073)	4.15226755
4	True hermaphroditism (HP:0010459)	4.01155877
5	Pancreatic fibrosis (HP:0100732)	4.00896089
6	Nephronophthisis (HP:0000090)	3.63504607
7	Pendular nystagmus (HP:0012043)	3.59805557
8	Type II lissencephaly (HP:0007260)	3.39012497
9	Hyperglycinuria (HP:0003108)	3.33020612
10	Congenital stationary night blindness (HP:0007642)	3.25174928
11	Molar tooth sign on MRI (HP:0002419)	3.23488845
12	Abnormality of midbrain morphology (HP:0002418)	3.23488845
13	Gaze-evoked nystagmus (HP:0000640)	3.22556384
14	Keratoconus (HP:0000563)	3.20730633
15	Increased corneal curvature (HP:0100692)	3.20730633
16	Decreased central vision (HP:0007663)	3.14364086
17	Bilateral microphthalmos (HP:0007633)	3.09471020
18	Cystic liver disease (HP:0006706)	3.01769757
19	Chorioretinal atrophy (HP:0000533)	3.00912787
20	Abnormality of the renal medulla (HP:0100957)	3.00702178
21	Prostate neoplasm (HP:0100787)	2.98326092
22	Hyperventilation (HP:0002883)	2.79399474
23	Abnormal biliary tract physiology (HP:0012439)	2.79273690
24	Bile duct proliferation (HP:0001408)	2.79273690
25	Abnormality of macular pigmentation (HP:0008002)	2.79180021
26	Abolished electroretinogram (ERG) (HP:0000550)	2.73074488
27	Medial flaring of the eyebrow (HP:0010747)	2.70335784
28	Action tremor (HP:0002345)	2.67030154
29	Abnormality of serine family amino acid metabolism (HP:0010894)	2.64825813
30	Abnormality of glycine metabolism (HP:0010895)	2.64825813
31	Hypoplasia of the fovea (HP:0007750)	2.60400074
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.60400074
33	Hypochromic microcytic anemia (HP:0004840)	2.60325786
34	Attenuation of retinal blood vessels (HP:0007843)	2.58839720
35	Febrile seizures (HP:0002373)	2.58441099
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56966829
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.55790178
38	Abnormality of alanine metabolism (HP:0010916)	2.55790178
39	Hyperalaninemia (HP:0003348)	2.55790178
40	Stomach cancer (HP:0012126)	2.51499712
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.46173407
42	Sclerocornea (HP:0000647)	2.43840633
43	Hypoplasia of the uterus (HP:0000013)	2.42076022
44	Abnormality of the renal cortex (HP:0011035)	2.42071975
45	Cerebellar dysplasia (HP:0007033)	2.41899366
46	Tubular atrophy (HP:0000092)	2.32206350
47	Thyroid-stimulating hormone excess (HP:0002925)	2.31746284
48	Male pseudohermaphroditism (HP:0000037)	2.28735543
49	Gait imbalance (HP:0002141)	2.26399751
50	Congenital, generalized hypertrichosis (HP:0004540)	2.24170979
51	Congenital primary aphakia (HP:0007707)	2.21850843
52	Absent speech (HP:0001344)	2.15526629
53	Chronic hepatic failure (HP:0100626)	2.13575685
54	Choroideremia (HP:0001139)	2.13106019
55	Furrowed tongue (HP:0000221)	2.10784121
56	Progressive inability to walk (HP:0002505)	2.10569108
57	Protruding tongue (HP:0010808)	2.10405114
58	Nephrogenic diabetes insipidus (HP:0009806)	2.07365717
59	Abnormality of the fovea (HP:0000493)	2.04787606
60	Genital tract atresia (HP:0001827)	2.04016973
61	Severe visual impairment (HP:0001141)	2.03574020
62	Ketoacidosis (HP:0001993)	2.02850357
63	Absent/shortened dynein arms (HP:0200106)	2.02367137
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.02367137
65	Focal seizures (HP:0007359)	2.02209088
66	Urinary bladder sphincter dysfunction (HP:0002839)	2.01763009
67	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99897598
68	Decreased circulating renin level (HP:0003351)	1.99334395
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99113605
70	Vaginal atresia (HP:0000148)	1.96493520
71	Partial agenesis of the corpus callosum (HP:0001338)	1.95911379
72	Congenital hepatic fibrosis (HP:0002612)	1.95554631
73	Pachygyria (HP:0001302)	1.94779792
74	Absence seizures (HP:0002121)	1.92986822
75	Abnormal finger flexion creases (HP:0006143)	1.91693736
76	Macular degeneration (HP:0000608)	1.91636972
77	Concave nail (HP:0001598)	1.90062695
78	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.89801907
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.89718355
80	Retinitis pigmentosa (HP:0000510)	1.89317478
81	Anencephaly (HP:0002323)	1.88536824
82	Inability to walk (HP:0002540)	1.88280315
83	Hydroxyprolinuria (HP:0003080)	1.86857594
84	Abnormality of proline metabolism (HP:0010907)	1.86857594
85	Clumsiness (HP:0002312)	1.86378370
86	Lissencephaly (HP:0001339)	1.86170913
87	Abnormality of the hepatic vasculature (HP:0006707)	1.85889782
88	Dialeptic seizures (HP:0011146)	1.85202373
89	Abnormal drinking behavior (HP:0030082)	1.84889145
90	Polydipsia (HP:0001959)	1.84889145
91	Ketosis (HP:0001946)	1.81524144
92	Widely spaced teeth (HP:0000687)	1.81302534
93	Abnormality of the nasal septum (HP:0000419)	1.80638810
94	Abnormality of the pubic bones (HP:0003172)	1.78867400
95	Hypochromic anemia (HP:0001931)	1.77649181
96	Volvulus (HP:0002580)	1.77527906
97	Postaxial foot polydactyly (HP:0001830)	1.76504377
98	Morphological abnormality of the middle ear (HP:0008609)	1.76297910
99	Astigmatism (HP:0000483)	1.74872136
100	Dysdiadochokinesis (HP:0002075)	1.73754827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.24389656
2	CDK19	4.94630871
3	BMPR1B	3.81613744
4	TIE1	3.16621820
5	INSRR	3.15108090
6	OXSR1	2.66895753
7	ADRBK2	2.60124119
8	PINK1	2.45746238
9	GRK1	2.36195012
10	ACVR1B	2.20537804
11	ZAK	2.20072152
12	STK38L	2.18490816
13	TAOK3	2.08857109
14	MAPK13	1.92361908
15	BCR	1.86640379
16	MAP4K2	1.79397970
17	NUAK1	1.58536785
18	TNK2	1.56655989
19	EPHA4	1.56600571
20	MAP3K4	1.51034527
21	LATS1	1.46518626
22	WNK3	1.40489174
23	TNIK	1.39421432
24	PNCK	1.34805265
25	KIT	1.26780885
26	STK3	1.24776054
27	TEC	1.23484532
28	WNK4	1.23227938
29	IRAK1	1.15581476
30	GRK7	1.11432827
31	MAP3K7	1.08302232
32	VRK1	1.04137637
33	DAPK2	0.99364495
34	TRIM28	0.99227534
35	TLK1	0.98816074
36	MAP2K7	0.98267668
37	ADRBK1	0.95469287
38	PTK2B	0.94222603
39	STK11	0.92955403
40	MUSK	0.92544357
41	TXK	0.89543428
42	CASK	0.84084267
43	BMPR2	0.80396694
44	PRKCE	0.79372713
45	TGFBR2	0.77243480
46	MARK1	0.71955034
47	NTRK3	0.69730867
48	MAPK15	0.67494151
49	IKBKB	0.63728927
50	DYRK2	0.62382357
51	PRKCG	0.60225886
52	PDK2	0.59303196
53	ERBB2	0.57923304
54	TAF1	0.57698788
55	MAPKAPK5	0.55530578
56	PLK2	0.54103937
57	GRK5	0.52505599
58	PIK3CA	0.50958017
59	CDK3	0.49325991
60	MATK	0.47794992
61	SIK2	0.47511872
62	MARK3	0.47162304
63	ABL1	0.47053234
64	VRK2	0.46806105
65	PBK	0.45897444
66	TGFBR1	0.45894375
67	ERBB3	0.44182046
68	CSNK1A1	0.43463706
69	MAP3K13	0.42253133
70	SGK2	0.40926020
71	MKNK2	0.40836520
72	RPS6KA4	0.38287345
73	PRKACA	0.37979686
74	IGF1R	0.37068142
75	RPS6KA6	0.36650123
76	EIF2AK2	0.35929289
77	CSNK1G2	0.34872617
78	STK39	0.34775554
79	DYRK3	0.33536961
80	CHUK	0.33331729
81	PRKCQ	0.32597467
82	ATR	0.31932972
83	CAMK2A	0.31583679
84	FER	0.31395393
85	PRKAA2	0.31239798
86	NEK2	0.30333010
87	CSNK1G3	0.28941714
88	MKNK1	0.28931999
89	SYK	0.28916876
90	JAK3	0.28707770
91	MAPKAPK3	0.28603740
92	PRKG1	0.27577976
93	RPS6KA5	0.27082831
94	OBSCN	0.26835857
95	PRKCA	0.26801513
96	FLT3	0.26769004
97	PHKG2	0.26451349
98	PHKG1	0.26451349
99	CSNK1A1L	0.25537281
100	HIPK2	0.25059642

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.23888739
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.22633888
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.17148475
4	Phototransduction_Homo sapiens_hsa04744	2.49925989
5	Butanoate metabolism_Homo sapiens_hsa00650	2.41511614
6	Nicotine addiction_Homo sapiens_hsa05033	2.32577538
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.29780592
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18888516
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14548004
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07150367
11	Olfactory transduction_Homo sapiens_hsa04740	2.04503436
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.90704102
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86292631
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84747304
15	Taste transduction_Homo sapiens_hsa04742	1.82045386
16	Caffeine metabolism_Homo sapiens_hsa00232	1.80187754
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.79008953
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77647148
19	Morphine addiction_Homo sapiens_hsa05032	1.59334334
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.52807603
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.46972622
22	beta-Alanine metabolism_Homo sapiens_hsa00410	1.44780575
23	Glycerolipid metabolism_Homo sapiens_hsa00561	1.43065735
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43025347
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.41109919
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.36954083
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32818094
28	Basal transcription factors_Homo sapiens_hsa03022	1.27187473
29	Retinol metabolism_Homo sapiens_hsa00830	1.26581891
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25081697
31	Asthma_Homo sapiens_hsa05310	1.19330476
32	Salivary secretion_Homo sapiens_hsa04970	1.19298509
33	Histidine metabolism_Homo sapiens_hsa00340	1.19232543
34	Insulin secretion_Homo sapiens_hsa04911	1.19130445
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18082595
36	Circadian entrainment_Homo sapiens_hsa04713	1.16708290
37	Homologous recombination_Homo sapiens_hsa03440	1.15242545
38	ABC transporters_Homo sapiens_hsa02010	1.14303326
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13078000
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.12451806
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.12209723
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10357511
43	Propanoate metabolism_Homo sapiens_hsa00640	1.08207418
44	GABAergic synapse_Homo sapiens_hsa04727	1.05937182
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.02753582
46	Calcium signaling pathway_Homo sapiens_hsa04020	1.02189136
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00628632
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98233771
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.97624602
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91166631
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86026458
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.84728112
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84479372
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.84271522
55	Serotonergic synapse_Homo sapiens_hsa04726	0.83795622
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81301645
57	Gastric acid secretion_Homo sapiens_hsa04971	0.80872979
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.80455824
59	Peroxisome_Homo sapiens_hsa04146	0.79284072
60	RNA polymerase_Homo sapiens_hsa03020	0.77877994
61	Long-term depression_Homo sapiens_hsa04730	0.77658248
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76748384
63	Cholinergic synapse_Homo sapiens_hsa04725	0.76302351
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76052419
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75633020
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.74082587
67	Allograft rejection_Homo sapiens_hsa05330	0.73993484
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.72690478
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.70519787
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69922825
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.67095698
72	Cocaine addiction_Homo sapiens_hsa05030	0.64615552
73	RNA degradation_Homo sapiens_hsa03018	0.62971386
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61514060
75	African trypanosomiasis_Homo sapiens_hsa05143	0.60352456
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59020846
77	Renin secretion_Homo sapiens_hsa04924	0.58527915
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56453130
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54700653
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51432911
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48043852
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.46877649
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46600704
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.44753705
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.44635366
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43720059
87	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42751042
88	Amphetamine addiction_Homo sapiens_hsa05031	0.40760971
89	Sulfur metabolism_Homo sapiens_hsa00920	0.39184506
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38038679
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37743556
92	Circadian rhythm_Homo sapiens_hsa04710	0.37028121
93	Metabolic pathways_Homo sapiens_hsa01100	0.36616270
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35338707
95	Fatty acid degradation_Homo sapiens_hsa00071	0.35163295
96	Oxidative phosphorylation_Homo sapiens_hsa00190	0.32438569
97	Purine metabolism_Homo sapiens_hsa00230	0.32024308
98	Mineral absorption_Homo sapiens_hsa04978	0.31526180
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30460948
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.30002004

RPL23AP66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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