RPL23AP69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)6.28314438
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.28314438
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.24212182
4DNA deamination (GO:0045006)5.50082466
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.14688834
6chaperone-mediated protein transport (GO:0072321)5.04595461
7ribosomal small subunit assembly (GO:0000028)4.90212142
8regulation of isotype switching to IgG isotypes (GO:0048302)4.54000128
9respiratory electron transport chain (GO:0022904)4.50399443
10electron transport chain (GO:0022900)4.46629191
11positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.38550390
12viral transcription (GO:0019083)4.25648742
13cytidine deamination (GO:0009972)4.24448887
14cytidine metabolic process (GO:0046087)4.24448887
15cytidine catabolic process (GO:0006216)4.24448887
16translational termination (GO:0006415)4.07837239
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.06053197
18maturation of SSU-rRNA (GO:0030490)3.88693217
19protein complex biogenesis (GO:0070271)3.87292224
20regulation of immunoglobulin secretion (GO:0051023)3.85983562
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77677893
22regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.74446269
23ATP biosynthetic process (GO:0006754)3.73471007
24protein targeting to ER (GO:0045047)3.73223967
25negative regulation of heart rate (GO:0010459)3.72667718
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.72045695
27NADH dehydrogenase complex assembly (GO:0010257)3.72045695
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72045695
29translational elongation (GO:0006414)3.71600110
30ribosomal large subunit biogenesis (GO:0042273)3.69039993
31cotranslational protein targeting to membrane (GO:0006613)3.67762287
32purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.56736325
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55829130
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.55677509
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.51494421
36protein localization to endoplasmic reticulum (GO:0070972)3.47589231
37mitochondrial respiratory chain complex assembly (GO:0033108)3.40049664
38mast cell activation (GO:0045576)3.39226031
39regulation of regulatory T cell differentiation (GO:0045589)3.39045580
40ribosomal small subunit biogenesis (GO:0042274)3.38606843
41GPI anchor biosynthetic process (GO:0006506)3.33142484
42mast cell degranulation (GO:0043303)3.28820628
43mast cell activation involved in immune response (GO:0002279)3.28820628
44water-soluble vitamin biosynthetic process (GO:0042364)3.27287863
45proteasome assembly (GO:0043248)3.26665412
46preassembly of GPI anchor in ER membrane (GO:0016254)3.26048113
47hydrogen ion transmembrane transport (GO:1902600)3.24087805
48GPI anchor metabolic process (GO:0006505)3.18551832
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.18129550
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17323444
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14439706
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13452164
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13452164
54negative regulation of mast cell activation (GO:0033004)3.10566436
55viral life cycle (GO:0019058)3.09179726
56translation (GO:0006412)3.08705683
57cellular protein complex disassembly (GO:0043624)3.07835875
58proton transport (GO:0015992)3.07398656
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04138958
60GTP biosynthetic process (GO:0006183)3.03743166
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02740416
62hydrogen transport (GO:0006818)3.01776148
63response to pheromone (GO:0019236)2.97810901
64regulation of T cell mediated cytotoxicity (GO:0001914)2.95050471
65translational initiation (GO:0006413)2.92890806
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88792607
67positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85741340
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84782867
69regulation of cellular amino acid metabolic process (GO:0006521)2.83655967
70protein-cofactor linkage (GO:0018065)2.80918829
71gonadal mesoderm development (GO:0007506)2.80444854
72positive regulation of isotype switching (GO:0045830)2.79851268
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.71314619
74termination of RNA polymerase III transcription (GO:0006386)2.71314619
75nucleoside triphosphate biosynthetic process (GO:0009142)2.69362898
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69142236
77positive regulation of prostaglandin secretion (GO:0032308)2.68979225
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65709601
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.64367012
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62737623
81RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.60330378
82negative regulation of B cell apoptotic process (GO:0002903)2.60111307
83positive regulation of T cell mediated immunity (GO:0002711)2.59829303
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55615420
85behavioral response to nicotine (GO:0035095)2.55606741
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54914000
87rRNA modification (GO:0000154)2.54680717
88positive regulation of DNA recombination (GO:0045911)2.54444268
89positive regulation of immunoglobulin mediated immune response (GO:0002891)2.54265681
90positive regulation of B cell mediated immunity (GO:0002714)2.54265681
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54003054
92immunoglobulin mediated immune response (GO:0016064)2.52902288
93cellular component biogenesis (GO:0044085)2.52818205
94pyrimidine nucleotide catabolic process (GO:0006244)2.52813629
95positive regulation of interleukin-17 production (GO:0032740)2.52489612
96protein targeting to membrane (GO:0006612)2.51761972
97positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.51000552
98regulation of hypersensitivity (GO:0002883)2.50827304
99base-excision repair, AP site formation (GO:0006285)2.47617443
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.47589341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.08442648
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.03347901
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98880342
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.60016925
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.21150948
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97793974
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.69155705
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67863116
9VDR_23849224_ChIP-Seq_CD4+_Human2.67670874
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63467392
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55071174
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33377870
13ELK1_19687146_ChIP-ChIP_HELA_Human2.25331323
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.24121464
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14029810
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13430009
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09169413
18ZNF274_21170338_ChIP-Seq_K562_Hela2.04164965
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02744178
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00541955
21FOXP3_21729870_ChIP-Seq_TREG_Human1.99179633
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.99016907
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94676533
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.93306739
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.92286527
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92209432
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84385227
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79674975
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67884377
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.64336456
31GATA3_26560356_Chip-Seq_TH2_Human1.63866910
32TAF15_26573619_Chip-Seq_HEK293_Human1.62079595
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59301536
34IRF1_19129219_ChIP-ChIP_H3396_Human1.52901660
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52036184
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50126948
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47379263
38TP53_22573176_ChIP-Seq_HFKS_Human1.47348103
39MYB_26560356_Chip-Seq_TH2_Human1.47323440
40MYC_18940864_ChIP-ChIP_HL60_Human1.43769078
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42267562
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41997052
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33801891
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.33801891
45VDR_22108803_ChIP-Seq_LS180_Human1.32491599
46EWS_26573619_Chip-Seq_HEK293_Human1.32303505
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31332035
48PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.30920777
49BCL6_27268052_Chip-Seq_Bcells_Human1.30726891
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28754529
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28392662
52AR_20517297_ChIP-Seq_VCAP_Human1.27791320
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24468915
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20985670
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20528279
56NANOG_19829295_ChIP-Seq_ESCs_Human1.20118225
57SOX2_19829295_ChIP-Seq_ESCs_Human1.20118225
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.18693927
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18547609
60TTF2_22483619_ChIP-Seq_HELA_Human1.18309952
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18180989
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16154794
63MYC_19829295_ChIP-Seq_ESCs_Human1.15754535
64EZH2_22144423_ChIP-Seq_EOC_Human1.14053571
65GATA3_27048872_Chip-Seq_THYMUS_Human1.13948170
66ERG_20517297_ChIP-Seq_VCAP_Human1.12525271
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12415546
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.11940439
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10320842
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10122431
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.09922955
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09803465
73DCP1A_22483619_ChIP-Seq_HELA_Human1.09409286
74NANOG_20526341_ChIP-Seq_ESCs_Human1.08186327
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05349048
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04913342
77SPI1_23547873_ChIP-Seq_NB4_Human1.04905673
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04856910
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04450602
80GABP_19822575_ChIP-Seq_HepG2_Human1.04236784
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03745794
82TAF2_19829295_ChIP-Seq_ESCs_Human1.02350809
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02064843
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00325197
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.00130442
86ERA_21632823_ChIP-Seq_H3396_Human1.00129624
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.99926108
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99666891
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.95925891
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95815322
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95745739
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95447584
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95170757
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94817595
95CIITA_25753668_ChIP-Seq_RAJI_Human0.94363319
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94342893
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.94218792
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94054672
99P300_27268052_Chip-Seq_Bcells_Human0.93535988
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93301238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.93759419
2MP0005671_abnormal_response_to4.49760814
3MP0009785_altered_susceptibility_to2.99255797
4MP0009379_abnormal_foot_pigmentation2.97015863
5MP0000685_abnormal_immune_system2.65524168
6MP0002166_altered_tumor_susceptibility2.51706453
7MP0000372_irregular_coat_pigmentation2.49848908
8MP0004147_increased_porphyrin_level2.39634786
9MP0001800_abnormal_humoral_immune2.37633718
10MP0002148_abnormal_hypersensitivity_rea2.33694776
11MP0003724_increased_susceptibility_to2.32955439
12MP0001873_stomach_inflammation2.30101959
13MP0008875_abnormal_xenobiotic_pharmacok2.13625470
14MP0002006_tumorigenesis2.11768848
15MP0008872_abnormal_physiological_respon2.10150242
16MP0006292_abnormal_olfactory_placode2.09832544
17MP0006072_abnormal_retinal_apoptosis2.07323753
18MP0003646_muscle_fatigue2.06469255
19MP0005000_abnormal_immune_tolerance2.04296720
20MP0005387_immune_system_phenotype1.89916501
21MP0001790_abnormal_immune_system1.89916501
22MP0005367_renal/urinary_system_phenotyp1.87248244
23MP0000516_abnormal_urinary_system1.87248244
24MP0009333_abnormal_splenocyte_physiolog1.85103651
25MP0003806_abnormal_nucleotide_metabolis1.83626957
26MP0002876_abnormal_thyroid_physiology1.82426180
27MP0002723_abnormal_immune_serum1.78261623
28MP0002102_abnormal_ear_morphology1.69679383
29MP0003878_abnormal_ear_physiology1.66774617
30MP0005377_hearing/vestibular/ear_phenot1.66774617
31MP0003786_premature_aging1.62686458
32MP0003195_calcinosis1.61351639
33MP0002452_abnormal_antigen_presenting1.60985375
34MP0008995_early_reproductive_senescence1.60751373
35MP0005646_abnormal_pituitary_gland1.54777711
36MP0001986_abnormal_taste_sensitivity1.54438106
37MP0001853_heart_inflammation1.51429261
38MP0002420_abnormal_adaptive_immunity1.51153021
39MP0010155_abnormal_intestine_physiology1.46950347
40MP0001919_abnormal_reproductive_system1.46568461
41MP0001819_abnormal_immune_cell1.46317214
42MP0002405_respiratory_system_inflammati1.39752696
43MP0005075_abnormal_melanosome_morpholog1.39509347
44MP0003866_abnormal_defecation1.38868284
45MP0001905_abnormal_dopamine_level1.38074179
46MP0005025_abnormal_response_to1.35687833
47MP0004142_abnormal_muscle_tone1.34716638
48MP0008877_abnormal_DNA_methylation1.32905662
49MP0003252_abnormal_bile_duct1.32674773
50MP0005389_reproductive_system_phenotype1.31865491
51MP0003763_abnormal_thymus_physiology1.26997723
52MP0002837_dystrophic_cardiac_calcinosis1.26958905
53MP0002277_abnormal_respiratory_mucosa1.26605302
54MP0002138_abnormal_hepatobiliary_system1.26337196
55MP0005551_abnormal_eye_electrophysiolog1.24999814
56MP0005410_abnormal_fertilization1.24697985
57MP0009764_decreased_sensitivity_to1.22157428
58MP0008775_abnormal_heart_ventricle1.21743140
59MP0002933_joint_inflammation1.15160582
60MP0006054_spinal_hemorrhage1.12524641
61MP0002398_abnormal_bone_marrow1.12138718
62MP0000716_abnormal_immune_system1.11143020
63MP0002163_abnormal_gland_morphology1.11080210
64MP0002234_abnormal_pharynx_morphology1.06752045
65MP0001845_abnormal_inflammatory_respons1.05683968
66MP0004145_abnormal_muscle_electrophysio1.00128365
67MP0005085_abnormal_gallbladder_physiolo0.99251596
68MP0002419_abnormal_innate_immunity0.98166091
69MP0006036_abnormal_mitochondrial_physio0.97118248
70MP0002160_abnormal_reproductive_system0.95563527
71MP0003183_abnormal_peptide_metabolism0.94961936
72MP0003879_abnormal_hair_cell0.93178423
73MP0000689_abnormal_spleen_morphology0.92760515
74MP0001765_abnormal_ion_homeostasis0.90573469
75MP0008469_abnormal_protein_level0.89931692
76MP0004782_abnormal_surfactant_physiolog0.89195411
77MP0005253_abnormal_eye_physiology0.88015187
78MP0002095_abnormal_skin_pigmentation0.87327647
79MP0000703_abnormal_thymus_morphology0.87315979
80MP0005645_abnormal_hypothalamus_physiol0.87304666
81MP0005636_abnormal_mineral_homeostasis0.85815787
82MP0002736_abnormal_nociception_after0.85774755
83MP0005084_abnormal_gallbladder_morpholo0.84231178
84MP0003011_delayed_dark_adaptation0.83570536
85MP0002429_abnormal_blood_cell0.82160592
86MP0005379_endocrine/exocrine_gland_phen0.78688093
87MP0002722_abnormal_immune_system0.77409364
88MP0005332_abnormal_amino_acid0.75369291
89MP0002132_abnormal_respiratory_system0.71873539
90MP0003186_abnormal_redox_activity0.71527435
91MP0004885_abnormal_endolymph0.70866640
92MP0003436_decreased_susceptibility_to0.70500608
93MP0001968_abnormal_touch/_nociception0.70291025
94MP0005166_decreased_susceptibility_to0.70135046
95MP0006276_abnormal_autonomic_nervous0.69472539
96MP0002693_abnormal_pancreas_physiology0.69470865
97MP0001440_abnormal_grooming_behavior0.68634654
98MP0001984_abnormal_olfaction0.67079115
99MP0004381_abnormal_hair_follicle0.66797760
100MP0009643_abnormal_urine_homeostasis0.66268640

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.17075483
2Hypoproteinemia (HP:0003075)4.83499612
3IgG deficiency (HP:0004315)4.68572411
4Acute necrotizing encephalopathy (HP:0006965)4.43609648
5Mitochondrial inheritance (HP:0001427)4.34156051
6Severe combined immunodeficiency (HP:0004430)4.04703518
7Abnormal mitochondria in muscle tissue (HP:0008316)3.99656871
8Progressive macrocephaly (HP:0004481)3.93426339
9Stomatitis (HP:0010280)3.84036049
10Acute encephalopathy (HP:0006846)3.83929092
11Increased CSF lactate (HP:0002490)3.83533236
12B lymphocytopenia (HP:0010976)3.68760661
13Hepatocellular necrosis (HP:0001404)3.66648884
14Panhypogammaglobulinemia (HP:0003139)3.56533774
15Increased hepatocellular lipid droplets (HP:0006565)3.53592968
16Hypoplasia of the thymus (HP:0000778)3.50620294
17Abnormality of B cell number (HP:0010975)3.42616157
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39004988
19Thyroiditis (HP:0100646)3.28766602
203-Methylglutaconic aciduria (HP:0003535)3.26857394
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25265761
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25265761
23Lipid accumulation in hepatocytes (HP:0006561)3.23950159
24T lymphocytopenia (HP:0005403)3.19431183
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12529368
26Hepatic necrosis (HP:0002605)3.12075068
27Elevated erythrocyte sedimentation rate (HP:0003565)3.05577279
28Combined immunodeficiency (HP:0005387)3.02452678
29Increased intramyocellular lipid droplets (HP:0012240)3.00901712
30Renal Fanconi syndrome (HP:0001994)2.94879465
31Abnormality of cells of the erythroid lineage (HP:0012130)2.89828920
32Exertional dyspnea (HP:0002875)2.88786871
33Cerebral edema (HP:0002181)2.87260854
34Abnormal number of erythroid precursors (HP:0012131)2.86928467
35Abnormality of T cell number (HP:0011839)2.81168981
36Erythroderma (HP:0001019)2.77012542
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63544542
38Lactic acidosis (HP:0003128)2.62655804
39Chronic sinusitis (HP:0011109)2.62627818
40Abnormality of T cells (HP:0002843)2.49112123
41Increased muscle lipid content (HP:0009058)2.48970249
42Optic disc pallor (HP:0000543)2.46528564
43Respiratory failure (HP:0002878)2.40085821
44Increased serum lactate (HP:0002151)2.39983544
45Rib fusion (HP:0000902)2.39475813
46Pancytopenia (HP:0001876)2.39439227
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37823044
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34803183
49Hypomagnesemia (HP:0002917)2.33319560
50Abnormal respiratory motile cilium physiology (HP:0012261)2.32781159
51Agammaglobulinemia (HP:0004432)2.30805562
52Abnormal rod and cone electroretinograms (HP:0008323)2.28446245
53Abnormal respiratory epithelium morphology (HP:0012253)2.27783624
54Abnormal respiratory motile cilium morphology (HP:0005938)2.27783624
55Congenital stationary night blindness (HP:0007642)2.26899591
56Attenuation of retinal blood vessels (HP:0007843)2.24624871
57Type II lissencephaly (HP:0007260)2.22946806
58Absent/shortened dynein arms (HP:0200106)2.21754964
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.21754964
60Congenital, generalized hypertrichosis (HP:0004540)2.15826218
61Abnormal drinking behavior (HP:0030082)2.15197265
62Polydipsia (HP:0001959)2.15197265
63Abnormality of eosinophils (HP:0001879)2.12253956
64Abolished electroretinogram (ERG) (HP:0000550)2.11360133
65Exercise intolerance (HP:0003546)2.10065961
66Leukodystrophy (HP:0002415)2.07278087
67Cleft eyelid (HP:0000625)2.05428263
68Increased IgM level (HP:0003496)2.02944770
69Abnormal spermatogenesis (HP:0008669)2.02795916
70Eosinophilia (HP:0001880)2.01836485
71Macrocytic anemia (HP:0001972)2.01801865
72Abnormality of magnesium homeostasis (HP:0004921)2.00689498
73Hypothermia (HP:0002045)1.96652764
74Pigmentary retinal degeneration (HP:0001146)1.95804519
75Pancreatic cysts (HP:0001737)1.94847226
76Abnormal ciliary motility (HP:0012262)1.91464057
77Large for gestational age (HP:0001520)1.90953984
78Generalized aminoaciduria (HP:0002909)1.90900367
79Congenital ichthyosiform erythroderma (HP:0007431)1.90818928
80Lethargy (HP:0001254)1.90071893
81Abnormality of the prostate (HP:0008775)1.87556833
82Reduced antithrombin III activity (HP:0001976)1.87346652
83Type I transferrin isoform profile (HP:0003642)1.87008311
84Aplasia/hypoplasia of the uterus (HP:0008684)1.86841372
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86814653
86Type 2 muscle fiber atrophy (HP:0003554)1.84471931
87Glycosuria (HP:0003076)1.83663148
88Abnormality of urine glucose concentration (HP:0011016)1.83663148
89Spastic paraparesis (HP:0002313)1.81713968
90Hyperglycinemia (HP:0002154)1.81427285
91Polyuria (HP:0000103)1.79715702
92Chronic diarrhea (HP:0002028)1.78818222
93Abnormality of T cell physiology (HP:0011840)1.77295821
94Abnormality of placental membranes (HP:0011409)1.76773318
95Amniotic constriction ring (HP:0009775)1.76773318
96Neonatal respiratory distress (HP:0002643)1.76615993
97Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76596406
98IgM deficiency (HP:0002850)1.76424428
99Tetany (HP:0001281)1.75765719
100Azoospermia (HP:0000027)1.74741903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.89770112
2TXK4.01089333
3BMPR23.68429028
4SCYL23.63118538
5MAP3K123.29182765
6TLK12.71978065
7MAP4K12.48090696
8ADRBK22.32556321
9NUAK12.29390833
10KDR2.16609308
11MST42.02552120
12FRK2.00534690
13GRK11.94174625
14CDK191.93895746
15ZAK1.92847004
16BCKDK1.89592146
17VRK21.79970734
18MYLK1.69934090
19TEC1.60391456
20STK161.47876015
21WNK41.35020827
22NME21.33808123
23ERBB31.32412628
24DAPK21.32290870
25CDK81.32081723
26KIT1.31885242
27FES1.22536548
28IKBKB1.20735997
29CSF1R1.18972972
30ZAP701.15675845
31ITK1.13538167
32SYK1.12963478
33OXSR11.09068214
34BTK1.07558593
35MAP3K111.03432108
36EIF2AK31.01251328
37DAPK10.96613689
38IKBKE0.92905640
39PLK40.92792123
40FLT30.85265269
41LYN0.83163807
42PHKG10.83020458
43PHKG20.83020458
44ILK0.82686285
45NME10.82276087
46TIE10.81397122
47DYRK20.81355250
48MAP4K20.81121206
49PIM20.79574997
50BMPR1B0.78829794
51PASK0.78778230
52LCK0.76749917
53STK390.76315899
54TESK20.75890027
55LRRK20.75236134
56TRPM70.73973057
57WNK30.73972903
58STK38L0.73866977
59INSRR0.70814241
60IGF1R0.67612808
61GRK60.66889840
62SRPK10.66179021
63PBK0.66133434
64RIPK40.64891078
65MAP3K140.63559335
66RPS6KA50.62784994
67OBSCN0.62784486
68VRK10.62422220
69TNK20.62043577
70CAMKK20.57324577
71DAPK30.56499224
72ACVR1B0.55611696
73PRKCQ0.55017331
74ADRBK10.52503676
75HCK0.51524643
76MATK0.50298089
77LIMK10.47964858
78CSK0.47652638
79IRAK40.47052251
80ROCK10.46361273
81PAK40.44658946
82CSNK2A10.43633222
83CSNK1G30.42066198
84ABL10.41935112
85MAP2K60.40488960
86PINK10.37747207
87CHUK0.37686941
88PIK3CG0.37572306
89GRK70.36434593
90MUSK0.35685252
91PIM10.33775447
92CSNK2A20.33754581
93PRKCA0.32891712
94AURKB0.32742820
95ATR0.29227041
96CAMKK10.28011671
97PRKACA0.27455304
98MAP2K70.26829358
99WNK10.26755923
100JAK30.26430857

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.36110584
2Oxidative phosphorylation_Homo sapiens_hsa001903.94212450
3Ribosome_Homo sapiens_hsa030103.70018068
4Allograft rejection_Homo sapiens_hsa053303.66115746
5Proteasome_Homo sapiens_hsa030503.50048602
6Autoimmune thyroid disease_Homo sapiens_hsa053203.37456606
7Parkinsons disease_Homo sapiens_hsa050123.11830521
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.06393421
9Graft-versus-host disease_Homo sapiens_hsa053323.04454785
10Primary immunodeficiency_Homo sapiens_hsa053402.82400924
11Type I diabetes mellitus_Homo sapiens_hsa049402.76455275
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29647775
13Alzheimers disease_Homo sapiens_hsa050102.20238386
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05957032
15RNA polymerase_Homo sapiens_hsa030202.04162734
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98855445
17Huntingtons disease_Homo sapiens_hsa050161.94694811
18Antigen processing and presentation_Homo sapiens_hsa046121.88961809
19Rheumatoid arthritis_Homo sapiens_hsa053231.81081864
20Homologous recombination_Homo sapiens_hsa034401.80427775
21Protein export_Homo sapiens_hsa030601.75118077
22Cardiac muscle contraction_Homo sapiens_hsa042601.66503882
23One carbon pool by folate_Homo sapiens_hsa006701.49138538
24Hematopoietic cell lineage_Homo sapiens_hsa046401.39266700
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30124953
26Viral myocarditis_Homo sapiens_hsa054161.29790542
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25622019
28Nitrogen metabolism_Homo sapiens_hsa009101.21831302
29Collecting duct acid secretion_Homo sapiens_hsa049661.15811658
30Staphylococcus aureus infection_Homo sapiens_hsa051501.11891046
31Leishmaniasis_Homo sapiens_hsa051401.08892522
32Phototransduction_Homo sapiens_hsa047441.02533189
33T cell receptor signaling pathway_Homo sapiens_hsa046601.00078051
34Basal transcription factors_Homo sapiens_hsa030220.99732711
35Systemic lupus erythematosus_Homo sapiens_hsa053220.99721683
36Nucleotide excision repair_Homo sapiens_hsa034200.97591471
37Pyrimidine metabolism_Homo sapiens_hsa002400.97174129
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97159969
39Fanconi anemia pathway_Homo sapiens_hsa034600.92243148
40Linoleic acid metabolism_Homo sapiens_hsa005910.88417725
41RNA degradation_Homo sapiens_hsa030180.86585918
42Sulfur metabolism_Homo sapiens_hsa009200.83006349
43Spliceosome_Homo sapiens_hsa030400.82615241
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79187223
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.73015802
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72692218
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70682272
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69519585
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68459597
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.67205596
51Mismatch repair_Homo sapiens_hsa034300.61548688
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60777276
53DNA replication_Homo sapiens_hsa030300.56108237
54Arachidonic acid metabolism_Homo sapiens_hsa005900.55955184
55Purine metabolism_Homo sapiens_hsa002300.55120139
56Regulation of autophagy_Homo sapiens_hsa041400.54088718
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.51022181
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.50433713
59Herpes simplex infection_Homo sapiens_hsa051680.48766313
60Chemical carcinogenesis_Homo sapiens_hsa052040.48165697
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46277144
62Butanoate metabolism_Homo sapiens_hsa006500.46244732
63Propanoate metabolism_Homo sapiens_hsa006400.46132683
64Caffeine metabolism_Homo sapiens_hsa002320.44868922
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.43614609
66Metabolic pathways_Homo sapiens_hsa011000.43047121
67Malaria_Homo sapiens_hsa051440.42796501
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39496152
69Olfactory transduction_Homo sapiens_hsa047400.38260192
70Tuberculosis_Homo sapiens_hsa051520.37626593
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37545057
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.37542244
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36864182
74Measles_Homo sapiens_hsa051620.36644113
75RNA transport_Homo sapiens_hsa030130.35708576
76Base excision repair_Homo sapiens_hsa034100.35686674
77Toxoplasmosis_Homo sapiens_hsa051450.35160081
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34929047
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32740945
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32690454
81Retinol metabolism_Homo sapiens_hsa008300.32409894
82Fatty acid biosynthesis_Homo sapiens_hsa000610.32186629
83Tryptophan metabolism_Homo sapiens_hsa003800.31832126
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30262241
85Peroxisome_Homo sapiens_hsa041460.29734223
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27320142
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25863052
88Phagosome_Homo sapiens_hsa041450.25510023
89Epstein-Barr virus infection_Homo sapiens_hsa051690.24861915
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23738648
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20367628
92Taste transduction_Homo sapiens_hsa047420.19752411
93Ether lipid metabolism_Homo sapiens_hsa005650.18332616
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17621537
95Arginine biosynthesis_Homo sapiens_hsa002200.14264557
96Folate biosynthesis_Homo sapiens_hsa007900.14224736
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13697858
98Fat digestion and absorption_Homo sapiens_hsa049750.13225231
99Influenza A_Homo sapiens_hsa051640.12974938
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.12874748

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