ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	9.21200376
2	thrombin receptor signaling pathway (GO:0070493)	6.95715576
3	neutrophil activation involved in immune response (GO:0002283)	6.55066018
4	regulation of integrin-mediated signaling pathway (GO:2001044)	5.49613408
5	regulation of platelet aggregation (GO:0090330)	5.47711451
6	regulation of platelet activation (GO:0010543)	5.18880628
7	negative regulation of heart rate (GO:0010459)	5.15487873
8	blood coagulation, intrinsic pathway (GO:0007597)	4.94950964
9	platelet aggregation (GO:0070527)	4.89952349
10	adenosine receptor signaling pathway (GO:0001973)	4.77154722
11	leukocyte migration involved in inflammatory response (GO:0002523)	4.75503689
12	negative regulation of norepinephrine secretion (GO:0010700)	4.66117349
13	regulation of Golgi to plasma membrane protein transport (GO:0042996)	4.56849143
14	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.51517387
15	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	4.48553717
16	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.46543617
17	negative regulation of thymocyte apoptotic process (GO:0070244)	4.37369233
18	positive regulation of endothelial cell differentiation (GO:0045603)	4.35946296
19	negative regulation of response to food (GO:0032096)	4.34425730
20	negative regulation of appetite (GO:0032099)	4.34425730
21	microtubule depolymerization (GO:0007019)	4.25483289
22	sequestering of actin monomers (GO:0042989)	4.23286198
23	negative regulation of platelet activation (GO:0010544)	4.21755021
24	positive regulation of mast cell activation (GO:0033005)	4.15141090
25	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	4.10238650
26	lipoxygenase pathway (GO:0019372)	3.97675628
27	positive regulation of protein homodimerization activity (GO:0090073)	3.94565633
28	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.91668664
29	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.90310604
30	regulation of lipoprotein metabolic process (GO:0050746)	3.89915482
31	negative regulation of protein localization to cell surface (GO:2000009)	3.88322577
32	platelet degranulation (GO:0002576)	3.84265994
33	platelet dense granule organization (GO:0060155)	3.72938999
34	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.72052770
35	neutrophil activation (GO:0042119)	3.71889673
36	fusion of sperm to egg plasma membrane (GO:0007342)	3.68805788
37	positive regulation of cAMP-mediated signaling (GO:0043950)	3.66300329
38	polyamine biosynthetic process (GO:0006596)	3.66226113
39	fatty acid elongation (GO:0030497)	3.66100164
40	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.64259669
41	megakaryocyte development (GO:0035855)	3.56561531
42	angiogenesis involved in wound healing (GO:0060055)	3.54510049
43	positive regulation of Rho protein signal transduction (GO:0035025)	3.46366052
44	mitochondrial calcium ion transport (GO:0006851)	3.46044591
45	low-density lipoprotein particle remodeling (GO:0034374)	3.45511303
46	relaxation of smooth muscle (GO:0044557)	3.40882976
47	long-chain fatty acid biosynthetic process (GO:0042759)	3.38553154
48	regulation of homotypic cell-cell adhesion (GO:0034110)	3.36876317
49	autophagic vacuole fusion (GO:0000046)	3.35039637
50	platelet formation (GO:0030220)	3.34138940
51	dopamine transport (GO:0015872)	3.27594308
52	granulocyte activation (GO:0036230)	3.27303620
53	negative regulation of heart contraction (GO:0045822)	3.26421135
54	beta-amyloid metabolic process (GO:0050435)	3.22430929
55	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.21225600
56	platelet activation (GO:0030168)	3.20604908
57	regulation of cilium movement (GO:0003352)	3.20483503
58	homotypic cell-cell adhesion (GO:0034109)	3.19678982
59	organelle membrane fusion (GO:0090174)	3.18810103
60	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.17735335
61	positive regulation of macrophage differentiation (GO:0045651)	3.14274182
62	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.12475810
63	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.12142070
64	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.12142070
65	extracellular fibril organization (GO:0043206)	3.11068305
66	pyrimidine nucleoside catabolic process (GO:0046135)	3.10292148
67	regulation of norepinephrine secretion (GO:0014061)	3.09676284
68	negative regulation of protein localization to plasma membrane (GO:1903077)	3.06970203
69	negative regulation of cation channel activity (GO:2001258)	3.05104578
70	positive regulation of granulocyte differentiation (GO:0030854)	3.03797882
71	negative regulation of neural precursor cell proliferation (GO:2000178)	3.03739787
72	regulation of integrin activation (GO:0033623)	3.00382315
73	negative regulation of catecholamine secretion (GO:0033604)	2.99126982
74	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.98193314
75	regulation of MHC class II biosynthetic process (GO:0045346)	2.97966462
76	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.97844248
77	positive regulation of hemostasis (GO:1900048)	2.93236127
78	positive regulation of blood coagulation (GO:0030194)	2.93236127
79	purinergic receptor signaling pathway (GO:0035587)	2.91763834
80	termination of signal transduction (GO:0023021)	2.89600880
81	adenosine metabolic process (GO:0046085)	2.88513862
82	positive regulation of muscle hypertrophy (GO:0014742)	2.88242560
83	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.88242560
84	mitochondrial calcium ion homeostasis (GO:0051560)	2.86760441
85	regulation of endothelial cell differentiation (GO:0045601)	2.84824689
86	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.81108483
87	plasma membrane fusion (GO:0045026)	2.80158026
88	xenobiotic catabolic process (GO:0042178)	2.80047633
89	positive regulation of systemic arterial blood pressure (GO:0003084)	2.79713599
90	phospholipid homeostasis (GO:0055091)	2.77093605
91	regulation of mitochondrial depolarization (GO:0051900)	2.75096438
92	regulation of female receptivity (GO:0045924)	2.74867814
93	phagocytosis, engulfment (GO:0006911)	2.72444179
94	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.72320356
95	negative regulation of T-helper cell differentiation (GO:0045623)	2.72320356
96	vesicle targeting (GO:0006903)	2.72028498
97	deoxyribose phosphate biosynthetic process (GO:0046385)	2.71072126
98	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.71072126
99	leukocyte degranulation (GO:0043299)	2.70643443
100	regulation of response to food (GO:0032095)	2.69983088

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	3.48171487
2	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	3.45640378
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.38263774
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.11748469
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10617820
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80984208
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.70145407
8	SCL_19346495_ChIP-Seq_HPC-7_Human	2.68063145
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.44956222
10	EWS_26573619_Chip-Seq_HEK293_Human	2.21466059
11	HTT_18923047_ChIP-ChIP_STHdh_Human	2.17095923
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.16225986
13	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.12940379
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07864627
15	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.07181255
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05047132
17	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.01775232
18	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.98815045
19	GATA1_19941826_ChIP-Seq_K562_Human	1.96339539
20	VDR_22108803_ChIP-Seq_LS180_Human	1.95210911
21	GATA2_19941826_ChIP-Seq_K562_Human	1.89563907
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.84862943
23	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.82175513
24	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.78745561
25	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.68589399
26	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.66378424
27	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.66378424
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.64863436
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.63962466
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58477249
31	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.58267902
32	P300_19829295_ChIP-Seq_ESCs_Human	1.56006978
33	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.55510224
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54639705
35	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.53286524
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51841563
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50346139
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50092819
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49721986
40	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.49640781
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.49574757
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48551538
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48166329
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44873298
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43467739
46	SPI1_23127762_ChIP-Seq_K562_Human	1.42771388
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42694920
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39546838
49	P53_22387025_ChIP-Seq_ESCs_Mouse	1.35972735
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34948659
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33680999
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33318177
53	GATA1_22025678_ChIP-Seq_K562_Human	1.32711342
54	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.30903653
55	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.28526075
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27876962
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26697854
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.26493782
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26379215
60	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.26295120
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24483221
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24483221
63	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.24313063
64	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.23843710
65	AR_25329375_ChIP-Seq_VCAP_Human	1.22966736
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.21001947
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18154114
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17293535
69	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.15103857
70	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.13939185
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13750640
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13559685
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13419851
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13358995
75	FUS_26573619_Chip-Seq_HEK293_Human	1.12101255
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11843286
77	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.10193915
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.09048611
79	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08421816
80	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.07228703
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06889955
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06693197
83	AR_20517297_ChIP-Seq_VCAP_Human	1.05633239
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05403873
85	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04980275
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04798947
87	STAT3_23295773_ChIP-Seq_U87_Human	1.04504023
88	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.03558320
89	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03215778
90	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.02649245
91	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01871670
92	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.01453185
93	JUN_21703547_ChIP-Seq_K562_Human	1.00544873
94	* TP53_22573176_ChIP-Seq_HFKS_Human	0.99394927
95	TCF4_23295773_ChIP-Seq_U87_Human	0.99056054
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98733383
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98548426
98	NFYA_21822215_ChIP-Seq_K562_Human	0.97754686
99	NFYB_21822215_ChIP-Seq_K562_Human	0.96174032
100	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.96099304

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	9.67943801
2	MP0008004_abnormal_stomach_pH	5.11091793
3	MP0003724_increased_susceptibility_to	3.23716444
4	MP0000465_gastrointestinal_hemorrhage	3.22386839
5	MP0005084_abnormal_gallbladder_morpholo	2.66481163
6	MP0000343_altered_response_to	2.35447299
7	MP0002736_abnormal_nociception_after	2.31232980
8	MP0009697_abnormal_copulation	2.10689679
9	MP0004510_myositis	2.10140636
10	MP0005410_abnormal_fertilization	2.06292787
11	MP0000230_abnormal_systemic_arterial	2.05085549
12	MP0006054_spinal_hemorrhage	2.03604207
13	MP0008872_abnormal_physiological_respon	2.02370306
14	MP0004084_abnormal_cardiac_muscle	1.96276627
15	MP0008877_abnormal_DNA_methylation	1.87215376
16	MP0008775_abnormal_heart_ventricle	1.79914577
17	MP0003303_peritoneal_inflammation	1.71622835
18	MP0004147_increased_porphyrin_level	1.68472939
19	MP0005083_abnormal_biliary_tract	1.64414318
20	MP0003828_pulmonary_edema	1.58453756
21	MP0001968_abnormal_touch/_nociception	1.58056382
22	MP0006276_abnormal_autonomic_nervous	1.56618208
23	MP0001835_abnormal_antigen_presentation	1.53914995
24	MP0000372_irregular_coat_pigmentation	1.50464450
25	MP0002102_abnormal_ear_morphology	1.49443486
26	MP0003718_maternal_effect	1.48969717
27	MP0001879_abnormal_lymphatic_vessel	1.48913482
28	MP0005671_abnormal_response_to	1.46713697
29	MP0006036_abnormal_mitochondrial_physio	1.44983699
30	MP0004215_abnormal_myocardial_fiber	1.43758823
31	MP0005646_abnormal_pituitary_gland	1.40643144
32	MP0003656_abnormal_erythrocyte_physiolo	1.40523405
33	MP0003638_abnormal_response/metabolism_	1.39555786
34	MP0002733_abnormal_thermal_nociception	1.38834939
35	MP0005397_hematopoietic_system_phenotyp	1.35734764
36	MP0001545_abnormal_hematopoietic_system	1.35734764
37	MP0000015_abnormal_ear_pigmentation	1.32145159
38	MP0005167_abnormal_blood-brain_barrier	1.30457146
39	MP0000358_abnormal_cell_content/	1.29965439
40	MP0004036_abnormal_muscle_relaxation	1.29775872
41	MP0004134_abnormal_chest_morphology	1.25769834
42	MP0003566_abnormal_cell_adhesion	1.25240505
43	MP0004142_abnormal_muscle_tone	1.24724749
44	MP0005058_abnormal_lysosome_morphology	1.23786268
45	MP0006035_abnormal_mitochondrial_morpho	1.22496071
46	MP0002148_abnormal_hypersensitivity_rea	1.20877227
47	MP0003186_abnormal_redox_activity	1.19895077
48	MP0001970_abnormal_pain_threshold	1.12124945
49	MP0001663_abnormal_digestive_system	1.12027774
50	MP0003950_abnormal_plasma_membrane	1.10211998
51	MP0010386_abnormal_urinary_bladder	1.09098032
52	MP0005187_abnormal_penis_morphology	1.08118949
53	MP0009763_increased_sensitivity_to	1.07469529
54	MP0002398_abnormal_bone_marrow	1.07391794
55	MP0003011_delayed_dark_adaptation	1.06023857
56	MP0005174_abnormal_tail_pigmentation	1.02510115
57	MP0004883_abnormal_blood_vessel	1.02102767
58	MP0008058_abnormal_DNA_repair	1.01501120
59	MP0000249_abnormal_blood_vessel	1.00951064
60	MP0002132_abnormal_respiratory_system	0.99443057
61	MP0002972_abnormal_cardiac_muscle	0.97014182
62	MP0003879_abnormal_hair_cell	0.95719889
63	MP0001905_abnormal_dopamine_level	0.95332240
64	MP0002735_abnormal_chemical_nociception	0.92314861
65	MP0005000_abnormal_immune_tolerance	0.90646986
66	MP0010329_abnormal_lipoprotein_level	0.89682774
67	MP0009764_decreased_sensitivity_to	0.89663652
68	MP0000689_abnormal_spleen_morphology	0.89390078
69	MP0005171_absent_coat_pigmentation	0.88574529
70	MP0010155_abnormal_intestine_physiology	0.88535498
71	MP0009765_abnormal_xenobiotic_induced	0.84485671
72	MP0001851_eye_inflammation	0.84446106
73	MP0009642_abnormal_blood_homeostasis	0.81683996
74	MP0004085_abnormal_heartbeat	0.81628826
75	MP0001544_abnormal_cardiovascular_syste	0.80082880
76	MP0005385_cardiovascular_system_phenoty	0.80082880
77	MP0009046_muscle_twitch	0.79555034
78	MP0008874_decreased_physiological_sensi	0.78958405
79	MP0004484_altered_response_of	0.75661752
80	MP0005620_abnormal_muscle_contractility	0.74382249
81	MP0000383_abnormal_hair_follicle	0.73646604
82	MP0002429_abnormal_blood_cell	0.73041243
83	MP0001756_abnormal_urination	0.72966458
84	MP0002295_abnormal_pulmonary_circulatio	0.70342967
85	MP0003136_yellow_coat_color	0.68552160
86	MP0002723_abnormal_immune_serum	0.68040092
87	MP0002128_abnormal_blood_circulation	0.67685578
88	MP0005165_increased_susceptibility_to	0.67658850
89	MP0008932_abnormal_embryonic_tissue	0.67589224
90	MP0005381_digestive/alimentary_phenotyp	0.67490358
91	MP0005535_abnormal_body_temperature	0.67487599
92	MP0001765_abnormal_ion_homeostasis	0.66066955
93	MP0003880_abnormal_central_pattern	0.65452713
94	MP0000858_altered_metastatic_potential	0.65326422
95	MP0002722_abnormal_immune_system	0.65172541
96	MP0002452_abnormal_antigen_presenting	0.63061543
97	MP0003698_abnormal_male_reproductive	0.61309318
98	MP0005551_abnormal_eye_electrophysiolog	0.61211948
99	MP0001845_abnormal_inflammatory_respons	0.58555664
100	MP0009333_abnormal_splenocyte_physiolog	0.56730274

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased mean platelet volume (HP:0011877)	9.53803811
2	Menorrhagia (HP:0000132)	9.41791405
3	Petechiae (HP:0000967)	9.19417873
4	Abnormal platelet volume (HP:0011876)	8.84066683
5	Purpura (HP:0000979)	7.80476629
6	Epistaxis (HP:0000421)	6.65907440
7	Gingival bleeding (HP:0000225)	5.74624100
8	Hyperlipoproteinemia (HP:0010980)	4.98907286
9	Impaired platelet aggregation (HP:0003540)	4.89211894
10	Abnormal platelet function (HP:0011869)	4.89211894
11	Poikilocytosis (HP:0004447)	4.23668699
12	Dyschromatopsia (HP:0007641)	4.19322346
13	Acanthocytosis (HP:0001927)	4.19195415
14	Spontaneous hematomas (HP:0007420)	3.71724091
15	Abnormal pupillary function (HP:0007686)	3.66129431
16	Conjunctival telangiectasia (HP:0000524)	3.36207552
17	Upper limb muscle weakness (HP:0003484)	3.34563506
18	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.34205220
19	Paralysis (HP:0003470)	3.13467888
20	Abnormal auditory evoked potentials (HP:0006958)	3.02418393
21	Abnormality of the vasculature of the conjunctiva (HP:0008054)	3.01384940
22	Abnormality of the common coagulation pathway (HP:0010990)	3.00913380
23	Abnormality of lateral ventricle (HP:0030047)	2.94797309
24	3-Methylglutaconic aciduria (HP:0003535)	2.93517435
25	Bruising susceptibility (HP:0000978)	2.91539044
26	Nausea (HP:0002018)	2.71060900
27	Generalized aminoaciduria (HP:0002909)	2.64356263
28	Renal Fanconi syndrome (HP:0001994)	2.56773728
29	Increased density of long bones (HP:0006392)	2.53320208
30	Papillary thyroid carcinoma (HP:0002895)	2.49659729
31	Renal cortical cysts (HP:0000803)	2.45442814
32	Hepatosplenomegaly (HP:0001433)	2.42080001
33	Tongue fasciculations (HP:0001308)	2.41832532
34	Decreased central vision (HP:0007663)	2.37552337
35	Tinnitus (HP:0000360)	2.21616102
36	Exertional dyspnea (HP:0002875)	2.17924151
37	Hypomagnesemia (HP:0002917)	2.09361073
38	Male infertility (HP:0003251)	2.04566898
39	Muscle fibrillation (HP:0010546)	2.04177338
40	Prolonged bleeding time (HP:0003010)	10.3341823
41	Abnormal ciliary motility (HP:0012262)	1.97503562
42	Joint swelling (HP:0001386)	1.95914261
43	Hypophosphatemic rickets (HP:0004912)	1.94156604
44	Thyroid carcinoma (HP:0002890)	1.92913973
45	Joint hemorrhage (HP:0005261)	1.91916213
46	Biliary tract neoplasm (HP:0100574)	1.89214132
47	Increased IgM level (HP:0003496)	1.85059430
48	Acute necrotizing encephalopathy (HP:0006965)	1.82959597
49	Polyphagia (HP:0002591)	1.81555317
50	Abnormality of iron homeostasis (HP:0011031)	1.78675083
51	Thyroid-stimulating hormone excess (HP:0002925)	1.78582657
52	Abnormality of transition element cation homeostasis (HP:0011030)	1.76400252
53	Abnormality of macrophages (HP:0004311)	1.74881216
54	Abnormality of renal resorption (HP:0011038)	1.72770357
55	Febrile seizures (HP:0002373)	1.71752301
56	Dysautonomia (HP:0002459)	1.71583720
57	Stomatitis (HP:0010280)	1.71349838
58	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.70110353
59	Abnormality of magnesium homeostasis (HP:0004921)	1.68494733
60	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.66901030
61	Hyperthyroidism (HP:0000836)	1.64440154
62	Hypoglycemic coma (HP:0001325)	1.63121681
63	Progressive macrocephaly (HP:0004481)	1.62047100
64	Insidious onset (HP:0003587)	1.61589712
65	Termporal pattern (HP:0011008)	1.61589712
66	Xanthomatosis (HP:0000991)	1.61378658
67	Spontaneous abortion (HP:0005268)	1.59920153
68	Degeneration of anterior horn cells (HP:0002398)	1.56534256
69	Abnormality of the anterior horn cell (HP:0006802)	1.56534256
70	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.56056843
71	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.56056843
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.55562301
73	Abnormality of alanine metabolism (HP:0010916)	1.55562301
74	Hyperalaninemia (HP:0003348)	1.55562301
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.55379110
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.54748772
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.54748772
78	Central scotoma (HP:0000603)	1.54261611
79	Abnormal spermatogenesis (HP:0008669)	1.53026144
80	Pancreatic islet-cell hyperplasia (HP:0004510)	1.52991320
81	Acute encephalopathy (HP:0006846)	1.51730538
82	Medial flaring of the eyebrow (HP:0010747)	1.51417653
83	Hypoplasia of the fovea (HP:0007750)	1.50856562
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.50856562
85	Episodic fever (HP:0001954)	1.47956631
86	Delusions (HP:0000746)	1.46140841
87	Mitochondrial inheritance (HP:0001427)	1.44331589
88	Abnormal gallbladder physiology (HP:0012438)	1.44301835
89	Cholecystitis (HP:0001082)	1.44301835
90	Abnormality of the fovea (HP:0000493)	1.44096428
91	Abnormality of the prostate (HP:0008775)	1.43565424
92	Neoplasm of the rectum (HP:0100743)	1.42774738
93	Type 2 muscle fiber atrophy (HP:0003554)	1.41222813
94	Proximal tubulopathy (HP:0000114)	1.39578528
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.39346175
96	Abnormality of the renal cortex (HP:0011035)	1.38627169
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.37863906
98	Absent/shortened dynein arms (HP:0200106)	1.37863906
99	Bladder carcinoma (HP:0002862)	1.37585735
100	Bladder neoplasm (HP:0009725)	1.37585735

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.80824581
2	EIF2AK1	4.07110872
3	RIPK4	3.83666333
4	MYLK	3.41174758
5	BMX	2.78171461
6	TEC	2.67565164
7	PTK2B	2.25726529
8	TRIM28	2.22406725
9	MAP4K2	2.05227641
10	BTK	2.02538719
11	BMPR2	1.98899804
12	TNIK	1.96434399
13	PLK2	1.95856955
14	CCNB1	1.87216063
15	TAOK3	1.86150248
16	STK3	1.82900432
17	ILK	1.80141516
18	ADRBK2	1.75866772
19	PNCK	1.66916738
20	CSF1R	1.63291733
21	SYK	1.61296247
22	BMPR1B	1.51967849
23	GRK5	1.51194280
24	NUAK1	1.49461225
25	PIK3CG	1.49180251
26	MAPK13	1.46443595
27	SIK3	1.36441226
28	FGR	1.21159562
29	MAP3K12	1.19320818
30	BCKDK	1.18104339
31	BCR	1.13711981
32	PAK1	1.11819704
33	FRK	1.10354687
34	ACVR1B	1.08681362
35	MINK1	1.03313613
36	STK24	1.03016070
37	MAPKAPK3	0.99858649
38	ZAK	0.97891130
39	PLK3	0.96917880
40	PAK3	0.95105737
41	GRK6	0.93525606
42	PIM2	0.87609179
43	MAP3K4	0.86440794
44	HCK	0.85138461
45	PKN1	0.84727811
46	MAP2K7	0.83157168
47	LYN	0.80089685
48	MAP3K5	0.77069756
49	ADRBK1	0.76070160
50	DAPK3	0.75354814
51	PINK1	0.74758560
52	GRK1	0.74240765
53	MARK3	0.73802222
54	EPHA3	0.71941103
55	NEK1	0.71397410
56	BRSK2	0.69350730
57	ERBB3	0.65326185
58	EPHB2	0.63170249
59	BLK	0.62966328
60	VRK1	0.60789403
61	STK4	0.60417370
62	NTRK3	0.59197556
63	EIF2AK3	0.58394154
64	ZAP70	0.57822721
65	IRAK1	0.57711727
66	IKBKB	0.57346114
67	PLK4	0.55527255
68	STK16	0.55386301
69	TESK2	0.55370050
70	RAF1	0.54575252
71	DYRK2	0.53957196
72	KSR1	0.52655060
73	PRKG1	0.51985069
74	CSNK1G3	0.51426456
75	FER	0.49173010
76	MATK	0.48313978
77	TXK	0.47276914
78	IRAK2	0.44832453
79	FES	0.44481743
80	PRKD1	0.44214736
81	YES1	0.42393572
82	ITK	0.41729006
83	DAPK1	0.41445049
84	LMTK2	0.41217600
85	PRKCG	0.40911096
86	CDK14	0.40173802
87	MAP2K1	0.39690176
88	TLK1	0.39438531
89	CSNK1G2	0.39349741
90	CAMK2A	0.37978898
91	CSNK1G1	0.37945110
92	PRKCB	0.37610714
93	DYRK3	0.37309646
94	ROCK1	0.36687136
95	PRKCE	0.35446015
96	PRKACG	0.34355591
97	MAP3K2	0.33479165
98	WNK3	0.33127445
99	CDK8	0.32001103
100	TAOK2	0.31300244

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Platelet activation_Homo sapiens_hsa04611	5.12965960
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	4.20555133
3	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	4.16028240
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.85120756
5	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.84107963
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.55531520
7	Mismatch repair_Homo sapiens_hsa03430	2.28356786
8	Fatty acid elongation_Homo sapiens_hsa00062	2.25894685
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02306738
10	Gap junction_Homo sapiens_hsa04540	2.01911843
11	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.97865781
12	Sulfur metabolism_Homo sapiens_hsa00920	1.80811138
13	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.77003117
14	Serotonergic synapse_Homo sapiens_hsa04726	1.74159123
15	ECM-receptor interaction_Homo sapiens_hsa04512	1.71458210
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.68911994
17	Glutathione metabolism_Homo sapiens_hsa00480	1.53587548
18	Alcoholism_Homo sapiens_hsa05034	1.47568872
19	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.46116293
20	Shigellosis_Homo sapiens_hsa05131	1.43881264
21	Chemokine signaling pathway_Homo sapiens_hsa04062	1.42152690
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.38012684
23	Parkinsons disease_Homo sapiens_hsa05012	1.32652012
24	Olfactory transduction_Homo sapiens_hsa04740	1.31593616
25	Phototransduction_Homo sapiens_hsa04744	1.25355234
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19314537
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10634608
28	Regulation of autophagy_Homo sapiens_hsa04140	1.09155066
29	Circadian entrainment_Homo sapiens_hsa04713	1.05972820
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.05619268
31	Long-term depression_Homo sapiens_hsa04730	1.05293847
32	Endocytosis_Homo sapiens_hsa04144	1.02592897
33	Phagosome_Homo sapiens_hsa04145	1.01952956
34	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99686328
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.99569699
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96301814
37	Purine metabolism_Homo sapiens_hsa00230	0.95260310
38	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.93321649
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.92540197
40	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91319947
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.90463738
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90303633
43	Protein export_Homo sapiens_hsa03060	0.90282105
44	Basal transcription factors_Homo sapiens_hsa03022	0.86911822
45	Morphine addiction_Homo sapiens_hsa05032	0.85192717
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.83396316
47	Homologous recombination_Homo sapiens_hsa03440	0.82427371
48	Pancreatic secretion_Homo sapiens_hsa04972	0.81387455
49	GABAergic synapse_Homo sapiens_hsa04727	0.80153612
50	Legionellosis_Homo sapiens_hsa05134	0.80131039
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79303283
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75876662
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75835050
54	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.74579644
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67548646
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65846896
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64516082
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62683614
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59865281
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59273668
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.57429863
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56938049
63	RNA polymerase_Homo sapiens_hsa03020	0.55422358
64	Ras signaling pathway_Homo sapiens_hsa04014	0.55084025
65	Malaria_Homo sapiens_hsa05144	0.53548463
66	Proteasome_Homo sapiens_hsa03050	0.52374991
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.52371398
68	Huntingtons disease_Homo sapiens_hsa05016	0.50692085
69	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.49547206
70	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.48470235
71	Oocyte meiosis_Homo sapiens_hsa04114	0.47865298
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.46905458
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.46688449
74	Asthma_Homo sapiens_hsa05310	0.44876217
75	Focal adhesion_Homo sapiens_hsa04510	0.42685631
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.42654314
77	Salmonella infection_Homo sapiens_hsa05132	0.42083031
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41864162
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41106639
80	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.40108923
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.38299097
82	Alzheimers disease_Homo sapiens_hsa05010	0.35467940
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.34637630
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34391807
85	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.34163756
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33256822
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33082984
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32697033
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31605327
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.31338252
91	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30552866
92	p53 signaling pathway_Homo sapiens_hsa04115	0.29799293
93	Cholinergic synapse_Homo sapiens_hsa04725	0.28128083
94	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.27464499
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.26707596
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.24321936
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.24200119
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23236828
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23033952
100	Melanoma_Homo sapiens_hsa05218	0.22923914

RPL23AP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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