ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.02496444
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.02496444
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.91356058
4	ribosomal small subunit assembly (GO:0000028)	4.80860860
5	oxygen transport (GO:0015671)	4.78319064
6	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.69908602
7	viral transcription (GO:0019083)	4.68706996
8	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.66312041
9	regulation of cilium movement (GO:0003352)	4.55837870
10	translational termination (GO:0006415)	4.43622645
11	ATP synthesis coupled proton transport (GO:0015986)	4.37712315
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.37712315
13	mannosylation (GO:0097502)	4.35931739
14	ribosomal large subunit biogenesis (GO:0042273)	4.22613936
15	water-soluble vitamin biosynthetic process (GO:0042364)	4.17965787
16	ribosomal small subunit biogenesis (GO:0042274)	4.09457605
17	gas transport (GO:0015669)	4.04348544
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.00392971
19	protein neddylation (GO:0045116)	3.97796706
20	protein targeting to ER (GO:0045047)	3.95155553
21	cotranslational protein targeting to membrane (GO:0006613)	3.95076130
22	translational elongation (GO:0006414)	3.86803592
23	regulation of mitotic spindle checkpoint (GO:1903504)	3.84143824
24	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.84143824
25	protein localization to endoplasmic reticulum (GO:0070972)	3.78946889
26	DNA deamination (GO:0045006)	3.78481368
27	pyrimidine nucleotide catabolic process (GO:0006244)	3.78279950
28	S-adenosylmethionine metabolic process (GO:0046500)	3.74979266
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.74118696
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.72563534
31	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.68959717
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.67031925
33	positive thymic T cell selection (GO:0045059)	3.59718898
34	GTP biosynthetic process (GO:0006183)	3.50559253
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.49319432
36	positive regulation of T cell chemotaxis (GO:0010820)	3.46974597
37	regulation of T cell chemotaxis (GO:0010819)	3.46974597
38	viral life cycle (GO:0019058)	3.39241733
39	piRNA metabolic process (GO:0034587)	3.35410686
40	regulation of microtubule-based movement (GO:0060632)	3.31839800
41	dopamine transport (GO:0015872)	3.31105441
42	protein deneddylation (GO:0000338)	3.27345630
43	maturation of SSU-rRNA (GO:0030490)	3.25529047
44	DNA methylation involved in gamete generation (GO:0043046)	3.22363331
45	cellular protein complex disassembly (GO:0043624)	3.21543030
46	aldehyde catabolic process (GO:0046185)	3.16819789
47	protein complex biogenesis (GO:0070271)	3.12476985
48	electron transport chain (GO:0022900)	3.09627495
49	nonmotile primary cilium assembly (GO:0035058)	3.07568239
50	chaperone-mediated protein transport (GO:0072321)	3.06796011
51	respiratory electron transport chain (GO:0022904)	3.04766394
52	axonemal dynein complex assembly (GO:0070286)	3.02200205
53	homocysteine metabolic process (GO:0050667)	2.98358326
54	metallo-sulfur cluster assembly (GO:0031163)	2.96980706
55	iron-sulfur cluster assembly (GO:0016226)	2.96980706
56	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.94076192
57	positive T cell selection (GO:0043368)	2.93495194
58	behavioral response to nicotine (GO:0035095)	2.92486171
59	positive regulation of T cell apoptotic process (GO:0070234)	2.91849884
60	proteasome assembly (GO:0043248)	2.88940985
61	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.88483825
62	pantothenate metabolic process (GO:0015939)	2.87489910
63	GPI anchor biosynthetic process (GO:0006506)	2.87310036
64	positive regulation of protein homodimerization activity (GO:0090073)	2.86383529
65	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.84759825
66	positive regulation of fatty acid oxidation (GO:0046321)	2.83327695
67	translation (GO:0006412)	2.81953922
68	somite development (GO:0061053)	2.81763459
69	translational initiation (GO:0006413)	2.80947024
70	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79752713
71	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79752713
72	NADH dehydrogenase complex assembly (GO:0010257)	2.79752713
73	regulation of neurotransmitter uptake (GO:0051580)	2.77668481
74	base-excision repair, AP site formation (GO:0006285)	2.77392027
75	hydrogen ion transmembrane transport (GO:1902600)	2.76665760
76	UTP biosynthetic process (GO:0006228)	2.76106071
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.74854843
78	negative regulation of execution phase of apoptosis (GO:1900118)	2.74842594
79	epithelial cilium movement (GO:0003351)	2.74517533
80	neural tube formation (GO:0001841)	2.74081512
81	GPI anchor metabolic process (GO:0006505)	2.72427734
82	positive regulation of glomerulus development (GO:0090193)	2.70198148
83	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.70109203
84	regulation of immunoglobulin secretion (GO:0051023)	2.67173605
85	single strand break repair (GO:0000012)	2.66969734
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.64654350
87	positive regulation of T cell migration (GO:2000406)	2.63402015
88	cullin deneddylation (GO:0010388)	2.62650616
89	termination of RNA polymerase III transcription (GO:0006386)	2.62218734
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.62218734
91	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.61893605
92	synaptic transmission, cholinergic (GO:0007271)	2.60756026
93	protein complex disassembly (GO:0043241)	2.58176506
94	ribonucleoprotein complex biogenesis (GO:0022613)	2.56577071
95	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	2.56282595
96	protein targeting to membrane (GO:0006612)	2.55489428
97	regulation of B cell receptor signaling pathway (GO:0050855)	2.54884409
98	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.54839130
99	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.54839130
100	macromolecular complex disassembly (GO:0032984)	2.53691377

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.51852619
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.02759746
3	VDR_22108803_ChIP-Seq_LS180_Human	3.95152621
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42808644
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.35665819
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.98074917
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.85257354
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.72412261
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.68958961
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54392446
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48884933
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27404631
13	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.03743073
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03720167
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01795104
16	TP53_22573176_ChIP-Seq_HFKS_Human	1.97351355
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.87010477
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84298225
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.79733229
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.78492118
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75765794
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.73581168
23	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.70402288
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67583370
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62024829
26	NANOG_20526341_ChIP-Seq_ESCs_Human	1.56294493
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56091695
28	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.55817749
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52063641
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.51031385
31	HTT_18923047_ChIP-ChIP_STHdh_Human	1.48766583
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44772990
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.43057997
34	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.43007334
35	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.38689705
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38514679
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.38062141
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37143834
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.37074921
40	FUS_26573619_Chip-Seq_HEK293_Human	1.33388115
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32711396
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32711396
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32572652
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.31393493
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.29397292
46	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29290426
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28957940
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.28626782
49	AR_20517297_ChIP-Seq_VCAP_Human	1.28281218
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.27976896
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.27475560
52	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.27339573
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25019661
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23463814
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23407719
56	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22808172
57	ERA_21632823_ChIP-Seq_H3396_Human	1.20646512
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19108656
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19108656
60	OCT4_20526341_ChIP-Seq_ESCs_Human	1.18866494
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18811441
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18112474
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.17571679
64	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17526982
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17112058
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10967111
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10782289
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09409167
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.08285097
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.07295383
71	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06666750
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06141397
73	GATA3_26560356_Chip-Seq_TH2_Human	1.05592356
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03119214
75	NCOR_22424771_ChIP-Seq_293T_Human	1.03048791
76	RXR_22108803_ChIP-Seq_LS180_Human	1.02348153
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.01554278
78	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01140182
79	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00810088
80	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00618763
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00483718
82	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.99706279
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98847418
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.98847418
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97827586
86	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.97182257
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.97144315
88	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96783493
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95825340
90	P300_19829295_ChIP-Seq_ESCs_Human	0.95078247
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94080002
92	E2F1_20622854_ChIP-Seq_HELA_Human	0.92883074
93	SOX2_21211035_ChIP-Seq_LN229_Human	0.92850470
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.92813855
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92783174
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.89897386
97	EWS_26573619_Chip-Seq_HEK293_Human	0.89722089
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89717206
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89197525
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88439115

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.52065508
2	MP0005645_abnormal_hypothalamus_physiol	3.29075226
3	MP0005671_abnormal_response_to	3.24879034
4	MP0004147_increased_porphyrin_level	3.02190667
5	MP0005377_hearing/vestibular/ear_phenot	2.93048337
6	MP0003878_abnormal_ear_physiology	2.93048337
7	MP0002138_abnormal_hepatobiliary_system	2.86405524
8	MP0005646_abnormal_pituitary_gland	2.85735040
9	MP0002736_abnormal_nociception_after	2.64597678
10	MP0002837_dystrophic_cardiac_calcinosis	2.54258096
11	MP0001968_abnormal_touch/_nociception	2.45883949
12	MP0008877_abnormal_DNA_methylation	2.24352850
13	MP0006292_abnormal_olfactory_placode	2.20949899
14	MP0002638_abnormal_pupillary_reflex	2.20005587
15	MP0009379_abnormal_foot_pigmentation	2.06701258
16	MP0008789_abnormal_olfactory_epithelium	2.05014253
17	MP0001986_abnormal_taste_sensitivity	1.99247806
18	MP0003879_abnormal_hair_cell	1.98826590
19	MP0002653_abnormal_ependyma_morphology	1.98524519
20	MP0002102_abnormal_ear_morphology	1.93900508
21	MP0002163_abnormal_gland_morphology	1.82228977
22	MP0003045_fibrosis	1.71897576
23	MP0000015_abnormal_ear_pigmentation	1.66371943
24	MP0001835_abnormal_antigen_presentation	1.63917357
25	MP0008875_abnormal_xenobiotic_pharmacok	1.62254066
26	MP0001905_abnormal_dopamine_level	1.61558986
27	MP0000685_abnormal_immune_system	1.56281099
28	MP0002095_abnormal_skin_pigmentation	1.55624821
29	MP0009333_abnormal_splenocyte_physiolog	1.48656842
30	MP0005499_abnormal_olfactory_system	1.47796616
31	MP0005394_taste/olfaction_phenotype	1.47796616
32	MP0008872_abnormal_physiological_respon	1.46317247
33	MP0004885_abnormal_endolymph	1.44955572
34	MP0004145_abnormal_muscle_electrophysio	1.43818149
35	MP0006276_abnormal_autonomic_nervous	1.42716854
36	MP0004142_abnormal_muscle_tone	1.40371841
37	MP0006072_abnormal_retinal_apoptosis	1.38370501
38	MP0002160_abnormal_reproductive_system	1.38151556
39	MP0003786_premature_aging	1.37491410
40	MP0005551_abnormal_eye_electrophysiolog	1.36583154
41	MP0003136_yellow_coat_color	1.35500592
42	MP0005389_reproductive_system_phenotype	1.34043924
43	MP0005379_endocrine/exocrine_gland_phen	1.32463099
44	MP0001764_abnormal_homeostasis	1.32441439
45	MP0003787_abnormal_imprinting	1.31742735
46	MP0001790_abnormal_immune_system	1.30711251
47	MP0005387_immune_system_phenotype	1.30711251
48	MP0008995_early_reproductive_senescence	1.30689580
49	MP0001800_abnormal_humoral_immune	1.30637357
50	MP0005083_abnormal_biliary_tract	1.28829140
51	MP0003806_abnormal_nucleotide_metabolis	1.28682567
52	MP0002733_abnormal_thermal_nociception	1.25537159
53	MP0008058_abnormal_DNA_repair	1.21658042
54	MP0003011_delayed_dark_adaptation	1.19928007
55	MP0001984_abnormal_olfaction	1.14905173
56	MP0002272_abnormal_nervous_system	1.12236581
57	MP0001919_abnormal_reproductive_system	1.10633570
58	MP0005636_abnormal_mineral_homeostasis	1.10501557
59	MP0003718_maternal_effect	1.10392937
60	MP0008775_abnormal_heart_ventricle	1.08402903
61	MP0005084_abnormal_gallbladder_morpholo	1.07432803
62	MP0002723_abnormal_immune_serum	1.05808220
63	MP0003880_abnormal_central_pattern	1.03551431
64	MP0006036_abnormal_mitochondrial_physio	1.03298059
65	MP0000538_abnormal_urinary_bladder	1.01807809
66	MP0005410_abnormal_fertilization	0.99919425
67	MP0004133_heterotaxia	0.96730575
68	MP0001440_abnormal_grooming_behavior	0.96686709
69	MP0001970_abnormal_pain_threshold	0.92139568
70	MP0000372_irregular_coat_pigmentation	0.90783661
71	MP0002277_abnormal_respiratory_mucosa	0.90086508
72	MP0003638_abnormal_response/metabolism_	0.88178622
73	MP0002420_abnormal_adaptive_immunity	0.87742377
74	MP0004043_abnormal_pH_regulation	0.87136743
75	MP0001819_abnormal_immune_cell	0.84503549
76	MP0001348_abnormal_lacrimal_gland	0.84480731
77	MP0002876_abnormal_thyroid_physiology	0.82642932
78	MP0005075_abnormal_melanosome_morpholog	0.81942035
79	MP0002928_abnormal_bile_duct	0.81583079
80	MP0005000_abnormal_immune_tolerance	0.80906274
81	MP0002452_abnormal_antigen_presenting	0.79867534
82	MP0002234_abnormal_pharynx_morphology	0.76309535
83	MP0004808_abnormal_hematopoietic_stem	0.72918036
84	MP0004019_abnormal_vitamin_homeostasis	0.72523262
85	MP0002405_respiratory_system_inflammati	0.70842495
86	MP0005395_other_phenotype	0.70478488
87	MP0002148_abnormal_hypersensitivity_rea	0.70460908
88	MP0005670_abnormal_white_adipose	0.70406814
89	MP0000689_abnormal_spleen_morphology	0.69786421
90	MP0009785_altered_susceptibility_to	0.68768128
91	MP0001529_abnormal_vocalization	0.67590565
92	MP0002752_abnormal_somatic_nervous	0.67341759
93	MP0003195_calcinosis	0.66429171
94	MP0003252_abnormal_bile_duct	0.66427077
95	MP0001501_abnormal_sleep_pattern	0.66223381
96	MP0005174_abnormal_tail_pigmentation	0.65918594
97	MP0005195_abnormal_posterior_eye	0.65106496
98	MP0000716_abnormal_immune_system	0.64849783
99	MP0002168_other_aberrant_phenotype	0.64757463
100	MP0000613_abnormal_salivary_gland	0.64085452

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	5.01615429
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.80111296
3	Muscle fiber atrophy (HP:0100295)	4.22024917
4	Abnormal hemoglobin (HP:0011902)	4.10227265
5	Acute necrotizing encephalopathy (HP:0006965)	4.05860227
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.70580917
7	Acute encephalopathy (HP:0006846)	3.70405990
8	Progressive macrocephaly (HP:0004481)	3.43202497
9	Mitochondrial inheritance (HP:0001427)	3.38810424
10	Renal Fanconi syndrome (HP:0001994)	3.38562269
11	Hyperglycinemia (HP:0002154)	3.28642712
12	Methylmalonic acidemia (HP:0002912)	3.09642423
13	Lipid accumulation in hepatocytes (HP:0006561)	3.08530274
14	Pancreatic fibrosis (HP:0100732)	3.04002478
15	Increased intramyocellular lipid droplets (HP:0012240)	2.96492514
16	Pancreatic cysts (HP:0001737)	2.95282762
17	Abnormality of homocysteine metabolism (HP:0010919)	2.92628124
18	Homocystinuria (HP:0002156)	2.92628124
19	Increased CSF lactate (HP:0002490)	2.91013760
20	Increased hepatocellular lipid droplets (HP:0006565)	2.87333047
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.80388763
22	Medial flaring of the eyebrow (HP:0010747)	2.77566097
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.76756948
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.76756948
25	Increased muscle lipid content (HP:0009058)	2.74188924
26	IgG deficiency (HP:0004315)	2.63476422
27	Congenital stationary night blindness (HP:0007642)	2.61130517
28	Pallor (HP:0000980)	2.60569512
29	Methylmalonic aciduria (HP:0012120)	2.57611079
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.56525061
31	Cerebral edema (HP:0002181)	2.52843071
32	Abnormality of midbrain morphology (HP:0002418)	2.52815828
33	Molar tooth sign on MRI (HP:0002419)	2.52815828
34	True hermaphroditism (HP:0010459)	2.50531340
35	Abnormality of the neuromuscular junction (HP:0003398)	2.48563443
36	Fatigable weakness (HP:0003473)	2.48563443
37	3-Methylglutaconic aciduria (HP:0003535)	2.46672534
38	Abnormality of cells of the erythroid lineage (HP:0012130)	2.46006874
39	Hypoplasia of the uterus (HP:0000013)	2.45149507
40	Supernumerary spleens (HP:0009799)	2.42331188
41	Increased IgM level (HP:0003496)	2.41910058
42	Exertional dyspnea (HP:0002875)	2.41286578
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40809645
44	Abnormality of alanine metabolism (HP:0010916)	2.40809645
45	Hyperalaninemia (HP:0003348)	2.40809645
46	Hepatocellular necrosis (HP:0001404)	2.37264273
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33484796
48	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33484796
49	Type II lissencephaly (HP:0007260)	2.32606931
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31494964
51	Gait imbalance (HP:0002141)	2.30865578
52	Nephronophthisis (HP:0000090)	2.28579829
53	Agammaglobulinemia (HP:0004432)	2.28066416
54	Generalized aminoaciduria (HP:0002909)	2.27235063
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26964983
56	Absent/shortened dynein arms (HP:0200106)	2.26964983
57	Abnormality of macular pigmentation (HP:0008002)	2.26843661
58	Optic disc pallor (HP:0000543)	2.25803016
59	Aplasia/hypoplasia of the uterus (HP:0008684)	2.24907308
60	Abnormality of renal resorption (HP:0011038)	2.23153831
61	Abnormal respiratory motile cilium physiology (HP:0012261)	2.19913798
62	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.18565162
63	Hepatic necrosis (HP:0002605)	2.18188124
64	Congenital primary aphakia (HP:0007707)	2.18107566
65	Central scotoma (HP:0000603)	2.16802439
66	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.15700905
67	Thrombocytosis (HP:0001894)	2.14887876
68	Asplenia (HP:0001746)	2.11920964
69	Hyperglycinuria (HP:0003108)	2.10556823
70	Lethargy (HP:0001254)	2.09050735
71	Stomatitis (HP:0010280)	2.08737584
72	Macrocytic anemia (HP:0001972)	2.08062458
73	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.07558105
74	Dicarboxylic aciduria (HP:0003215)	2.07558105
75	Abnormality of serine family amino acid metabolism (HP:0010894)	2.06543767
76	Abnormality of glycine metabolism (HP:0010895)	2.06543767
77	Type I transferrin isoform profile (HP:0003642)	2.05519570
78	Absent phalangeal crease (HP:0006109)	2.00058078
79	Attenuation of retinal blood vessels (HP:0007843)	1.99877634
80	Pancytopenia (HP:0001876)	1.99847351
81	Respiratory difficulties (HP:0002880)	1.99060301
82	Anencephaly (HP:0002323)	1.98848325
83	Abnormal drinking behavior (HP:0030082)	1.98711400
84	Polydipsia (HP:0001959)	1.98711400
85	Abnormal number of erythroid precursors (HP:0012131)	1.97898865
86	Nephrogenic diabetes insipidus (HP:0009806)	1.95791994
87	Weak cry (HP:0001612)	1.95146163
88	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.95119261
89	Hypoproteinemia (HP:0003075)	1.95013129
90	Abnormality of the fovea (HP:0000493)	1.94258521
91	Spontaneous abortion (HP:0005268)	1.91043470
92	Pendular nystagmus (HP:0012043)	1.90585328
93	Decreased muscle mass (HP:0003199)	1.90013839
94	Glycosuria (HP:0003076)	1.88420535
95	Abnormality of urine glucose concentration (HP:0011016)	1.88420535
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88303904
97	Abnormal ciliary motility (HP:0012262)	1.86484218
98	Abnormality of serum amino acid levels (HP:0003112)	1.85960642
99	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84315759
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83933776

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.36153298
2	FRK	3.30887332
3	ADRBK2	3.16975927
4	KDR	2.82759101
5	PDK2	2.67849178
6	BCKDK	2.44071506
7	TLK1	2.39544142
8	NUAK1	2.36541623
9	PINK1	2.34398123
10	GRK1	2.22707312
11	NME2	2.18677136
12	MAP4K1	2.13614084
13	TAOK3	2.01873109
14	CAMKK2	1.94137808
15	ZAK	1.93045314
16	PRKCQ	1.89291737
17	RIPK4	1.85358461
18	VRK2	1.84273803
19	PRKD3	1.74500539
20	TEC	1.63736626
21	SYK	1.62910650
22	STK16	1.62696749
23	TXK	1.52155301
24	WNK4	1.38241904
25	EPHA4	1.35085032
26	MAPK13	1.32968197
27	PHKG1	1.32533467
28	PHKG2	1.32533467
29	ITK	1.29986705
30	TRPM7	1.28577407
31	ADRBK1	1.28491689
32	SCYL2	1.27776451
33	RPS6KA5	1.23638700
34	OBSCN	1.21776572
35	IKBKE	1.20454336
36	MAP4K2	1.17157475
37	IKBKB	1.12415929
38	PIK3CA	1.04564567
39	BTK	0.99438464
40	CCNB1	0.98999012
41	LRRK2	0.98047739
42	JAK3	0.97986528
43	TNK2	0.96305451
44	MAPKAPK5	0.95251744
45	MAP3K11	0.90769392
46	VRK1	0.88697090
47	DYRK2	0.88424188
48	MAPKAPK3	0.83401919
49	KIT	0.82103835
50	STK3	0.79606894
51	CAMK1	0.78071636
52	NTRK2	0.76924328
53	CHUK	0.76419965
54	ZAP70	0.75648560
55	ABL2	0.75109367
56	MAP2K1	0.72872533
57	LYN	0.72837212
58	MAP3K13	0.72375535
59	PRKCG	0.72211750
60	DAPK2	0.72050604
61	CAMKK1	0.71850645
62	TIE1	0.66627588
63	INSRR	0.66413746
64	STK39	0.65420595
65	CSNK2A2	0.65039077
66	RPS6KA6	0.64760117
67	RPS6KB1	0.63944675
68	PKN1	0.63673258
69	MATK	0.63081262
70	CAMK2A	0.62435619
71	NEK1	0.61788673
72	CSNK1G3	0.61605473
73	MAP3K9	0.60284787
74	CSF1R	0.60140767
75	PAK3	0.57939298
76	PRKACA	0.57425590
77	WNK3	0.57238855
78	CSNK1A1	0.56200907
79	ILK	0.55747467
80	BRSK2	0.55389273
81	GRK6	0.53562723
82	CSNK2A1	0.53461221
83	MKNK1	0.51895826
84	DMPK	0.49957597
85	RPS6KA2	0.49058220
86	PIK3CG	0.48123421
87	BMPR1B	0.48010190
88	RPS6KC1	0.47925330
89	RPS6KL1	0.47925330
90	LCK	0.46894491
91	PLK4	0.46711321
92	TESK2	0.45074833
93	CHEK2	0.43583656
94	PRKCH	0.43241960
95	IGF1R	0.43121596
96	PRKCD	0.43108194
97	ROCK1	0.43101604
98	NME1	0.42991214
99	PRKCA	0.42864269
100	PRKCZ	0.42310094

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.54508432
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65300476
3	Parkinsons disease_Homo sapiens_hsa05012	3.21916168
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.19253584
5	Proteasome_Homo sapiens_hsa03050	2.94614914
6	Asthma_Homo sapiens_hsa05310	2.67942738
7	One carbon pool by folate_Homo sapiens_hsa00670	2.34960755
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.28387836
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19294650
10	Protein export_Homo sapiens_hsa03060	2.09708494
11	Phototransduction_Homo sapiens_hsa04744	2.09165561
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93776354
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.91580100
14	Allograft rejection_Homo sapiens_hsa05330	1.89511023
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.89080883
16	Huntingtons disease_Homo sapiens_hsa05016	1.82323359
17	Alzheimers disease_Homo sapiens_hsa05010	1.81370854
18	RNA polymerase_Homo sapiens_hsa03020	1.75696253
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.75228359
20	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.66002189
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.63483675
22	Peroxisome_Homo sapiens_hsa04146	1.55186931
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.48754476
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46697301
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.44557691
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41377552
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38186786
28	Basal transcription factors_Homo sapiens_hsa03022	1.37144623
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.30796660
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.22972621
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22271396
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.19205348
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15746498
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.14320845
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.09396882
36	RNA degradation_Homo sapiens_hsa03018	1.09138782
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.06716289
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.05865814
39	Retinol metabolism_Homo sapiens_hsa00830	1.04685130
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04657148
41	Caffeine metabolism_Homo sapiens_hsa00232	1.04253899
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02908507
43	Homologous recombination_Homo sapiens_hsa03440	1.00555918
44	Nicotine addiction_Homo sapiens_hsa05033	0.99979079
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.95489932
46	Malaria_Homo sapiens_hsa05144	0.95125852
47	Sulfur metabolism_Homo sapiens_hsa00920	0.94460347
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93905660
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91687404
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91580740
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.89228638
52	Base excision repair_Homo sapiens_hsa03410	0.89216988
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89209179
54	Olfactory transduction_Homo sapiens_hsa04740	0.84818131
55	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.83684049
56	Propanoate metabolism_Homo sapiens_hsa00640	0.81878903
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.77919454
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76920962
59	Purine metabolism_Homo sapiens_hsa00230	0.76884494
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76220865
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76092496
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75616000
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75129504
64	Butanoate metabolism_Homo sapiens_hsa00650	0.75090658
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74511269
66	Sulfur relay system_Homo sapiens_hsa04122	0.73855413
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70756024
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69999804
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.65373057
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64800910
71	Folate biosynthesis_Homo sapiens_hsa00790	0.62358452
72	Metabolic pathways_Homo sapiens_hsa01100	0.62189180
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.61893567
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61283159
75	Taste transduction_Homo sapiens_hsa04742	0.60032260
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57820035
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56484856
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49836880
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46576623
80	Morphine addiction_Homo sapiens_hsa05032	0.42287313
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42115785
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41677856
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40243499
84	Viral myocarditis_Homo sapiens_hsa05416	0.39358411
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37445139
86	ABC transporters_Homo sapiens_hsa02010	0.35059146
87	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.34606319
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33051621
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30275015
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.28899839
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.28568087
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.28062457
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27987999
94	Salivary secretion_Homo sapiens_hsa04970	0.27607665
95	GABAergic synapse_Homo sapiens_hsa04727	0.26994418
96	Glutathione metabolism_Homo sapiens_hsa00480	0.26338913
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.24283462
98	Serotonergic synapse_Homo sapiens_hsa04726	0.23942269
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22749357
100	Insulin secretion_Homo sapiens_hsa04911	0.22460296

RPL23AP71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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