RPL23AP73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)6.37596366
2water-soluble vitamin biosynthetic process (GO:0042364)6.19714529
3regulation of regulatory T cell differentiation (GO:0045589)5.96339076
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.56546018
5regulation of isotype switching to IgG isotypes (GO:0048302)5.39136169
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.25190973
7dendritic cell chemotaxis (GO:0002407)5.25032317
8tachykinin receptor signaling pathway (GO:0007217)5.20582001
9positive regulation of isotype switching (GO:0045830)4.46473058
10positive regulation of T-helper 1 type immune response (GO:0002827)4.29767184
11positive regulation of T cell differentiation in thymus (GO:0033089)4.20092903
12ribosome assembly (GO:0042255)4.18438250
13GTP biosynthetic process (GO:0006183)4.09090451
14L-fucose catabolic process (GO:0042355)4.06723251
15fucose catabolic process (GO:0019317)4.06723251
16L-fucose metabolic process (GO:0042354)4.06723251
17dendritic cell migration (GO:0036336)4.04648076
18positive regulation of defense response to virus by host (GO:0002230)4.01504146
19positive regulation of DNA recombination (GO:0045911)3.94714049
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89158512
21ATP synthesis coupled proton transport (GO:0015986)3.89158512
22regulation of T cell receptor signaling pathway (GO:0050856)3.88947087
23negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.85953188
24positive regulation of cell fate commitment (GO:0010455)3.82954979
25DNA deamination (GO:0045006)3.73507942
26neural tube formation (GO:0001841)3.59301968
27positive regulation of T cell migration (GO:2000406)3.56911677
28regulation of T-helper 1 type immune response (GO:0002825)3.56293660
29tolerance induction (GO:0002507)3.54426212
30transcription from mitochondrial promoter (GO:0006390)3.53773586
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48430492
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46793707
33positive regulation of interleukin-17 production (GO:0032740)3.45756569
34chemokine-mediated signaling pathway (GO:0070098)3.44800766
35UTP biosynthetic process (GO:0006228)3.43849747
36auditory receptor cell differentiation (GO:0042491)3.43720008
37regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.43673338
38behavioral response to nicotine (GO:0035095)3.42423970
39negative regulation of B cell apoptotic process (GO:0002903)3.37817657
40nucleoside diphosphate phosphorylation (GO:0006165)3.33444155
41phosphatidylinositol acyl-chain remodeling (GO:0036149)3.33416250
42heme transport (GO:0015886)3.25858941
43response to pheromone (GO:0019236)3.24217328
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.21499006
45piRNA metabolic process (GO:0034587)3.20977395
46tryptophan catabolic process (GO:0006569)3.18614002
47indole-containing compound catabolic process (GO:0042436)3.18614002
48indolalkylamine catabolic process (GO:0046218)3.18614002
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17200302
50mesonephros development (GO:0001823)3.15317356
51UTP metabolic process (GO:0046051)3.10976962
52signal peptide processing (GO:0006465)3.05187459
53regulation of T cell migration (GO:2000404)3.01815863
54positive regulation of T cell cytokine production (GO:0002726)2.99098002
55negative regulation of T cell differentiation in thymus (GO:0033085)2.99029017
56regulation of cytokine production involved in inflammatory response (GO:1900015)2.96835814
57regulation of memory T cell differentiation (GO:0043380)2.94887151
58pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.94548715
59axonemal dynein complex assembly (GO:0070286)2.93758172
60regulation of vitamin D biosynthetic process (GO:0060556)2.92500456
61viral protein processing (GO:0019082)2.92063146
62kynurenine metabolic process (GO:0070189)2.90774458
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90325872
64regulation of action potential (GO:0098900)2.89238307
65cellular biogenic amine catabolic process (GO:0042402)2.88593203
66amine catabolic process (GO:0009310)2.88593203
67negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.88184755
68positive regulation of immunoglobulin production (GO:0002639)2.87414750
69positive regulation of lymphocyte migration (GO:2000403)2.84061978
70dendritic spine morphogenesis (GO:0060997)2.83925249
71positive regulation of T cell chemotaxis (GO:0010820)2.83765544
72regulation of T cell chemotaxis (GO:0010819)2.83765544
73positive regulation of activated T cell proliferation (GO:0042104)2.83603059
74regulation of T cell differentiation in thymus (GO:0033081)2.83450130
75positive regulation of interleukin-12 production (GO:0032735)2.82599490
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.79982103
77ncRNA 3-end processing (GO:0043628)2.76114684
78pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.75753017
79positive regulation of B cell mediated immunity (GO:0002714)2.74124502
80positive regulation of immunoglobulin mediated immune response (GO:0002891)2.74124502
81endoderm formation (GO:0001706)2.74103866
82protein K11-linked deubiquitination (GO:0035871)2.73350903
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73171347
84ribosomal small subunit assembly (GO:0000028)2.72854687
85positive regulation of fatty acid transport (GO:2000193)2.71447943
86purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71234319
87activated T cell proliferation (GO:0050798)2.70930762
88phosphatidylserine acyl-chain remodeling (GO:0036150)2.68818482
89phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.68150288
90detection of light stimulus involved in visual perception (GO:0050908)2.68099838
91detection of light stimulus involved in sensory perception (GO:0050962)2.68099838
92CTP metabolic process (GO:0046036)2.64823768
93CTP biosynthetic process (GO:0006241)2.64823768
94regulation of immunoglobulin production (GO:0002637)2.63220108
95folic acid metabolic process (GO:0046655)2.59843976
96pyrimidine nucleotide biosynthetic process (GO:0006221)2.58862257
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58789583
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58789583
99isotype switching (GO:0045190)2.58789583
100positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.58514640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06698574
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70865570
3ZNF274_21170338_ChIP-Seq_K562_Hela3.10139168
4VDR_22108803_ChIP-Seq_LS180_Human2.91015575
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60698818
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.54762829
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38857496
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35851598
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.15289847
10IGF1R_20145208_ChIP-Seq_DFB_Human2.12127528
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.05649261
12BP1_19119308_ChIP-ChIP_Hs578T_Human1.97375937
13PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94711339
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94484764
15TAF15_26573619_Chip-Seq_HEK293_Human1.90662193
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.90597334
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89979303
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.87451878
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86951497
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84200875
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80027325
22TP53_22573176_ChIP-Seq_HFKS_Human1.78903042
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77342454
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77342454
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61957215
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61031145
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60579623
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60327690
29EWS_26573619_Chip-Seq_HEK293_Human1.58436656
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55193630
31GATA3_26560356_Chip-Seq_TH2_Human1.49877641
32VDR_23849224_ChIP-Seq_CD4+_Human1.49265947
33FUS_26573619_Chip-Seq_HEK293_Human1.48642015
34MYC_18940864_ChIP-ChIP_HL60_Human1.46708936
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44996158
36HOXB7_26014856_ChIP-Seq_BT474_Human1.43882684
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40293986
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40139311
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40099235
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.39202050
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39171536
42EGR1_19032775_ChIP-ChIP_M12_Human1.39117621
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36676329
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.33097007
45SOX2_19829295_ChIP-Seq_ESCs_Human1.32305425
46NANOG_19829295_ChIP-Seq_ESCs_Human1.32305425
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31704730
48ELK1_19687146_ChIP-ChIP_HELA_Human1.29457303
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.28067992
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27506494
51ER_23166858_ChIP-Seq_MCF-7_Human1.26849815
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.26322545
53IRF1_19129219_ChIP-ChIP_H3396_Human1.25804842
54RUNX_20019798_ChIP-Seq_JUKART_Human1.24088930
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23046575
56P53_21459846_ChIP-Seq_SAOS-2_Human1.21700544
57P300_19829295_ChIP-Seq_ESCs_Human1.20478804
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19454534
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16082509
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15475613
61AR_20517297_ChIP-Seq_VCAP_Human1.12612467
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.12471035
63FOXP3_21729870_ChIP-Seq_TREG_Human1.12171016
64GATA3_27048872_Chip-Seq_THYMUS_Human1.12014744
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11729888
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.11729888
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11291072
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10525482
69REST_21632747_ChIP-Seq_MESCs_Mouse1.10371452
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.09983340
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06620808
72NCOR_22424771_ChIP-Seq_293T_Human1.06030151
73FOXH1_21741376_ChIP-Seq_ESCs_Human1.05240612
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04873240
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04606341
76CBP_20019798_ChIP-Seq_JUKART_Human1.04606341
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04588781
78ZNF263_19887448_ChIP-Seq_K562_Human1.03950234
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03080346
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02966765
81TCF4_23295773_ChIP-Seq_U87_Human1.02415648
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01240213
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.00556074
84STAT1_20625510_ChIP-Seq_HELA_Human0.96954864
85GBX2_23144817_ChIP-Seq_PC3_Human0.96707741
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96345243
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95488045
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94197264
89DROSHA_22980978_ChIP-Seq_HELA_Human0.93646177
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93478971
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92386493
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90267151
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90170751
94AR_25329375_ChIP-Seq_VCAP_Human0.89058669
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89019713
96CTCF_20526341_ChIP-Seq_ESCs_Human0.85769787
97MYC_19829295_ChIP-Seq_ESCs_Human0.85377248
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85345154
99ERA_21632823_ChIP-Seq_H3396_Human0.84149694
100PHF8_20622853_ChIP-Seq_HELA_Human0.83160800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000604_amyloidosis4.81386454
2MP0001835_abnormal_antigen_presentation4.31228734
3MP0003329_amyloid_beta_deposits3.47147476
4MP0004858_abnormal_nervous_system2.77121108
5MP0003300_gastrointestinal_ulcer2.44095443
6MP0008877_abnormal_DNA_methylation2.40943041
7MP0003646_muscle_fatigue2.39370640
8MP0000685_abnormal_immune_system2.36655068
9MP0002148_abnormal_hypersensitivity_rea2.35810271
10MP0001790_abnormal_immune_system2.04464956
11MP0005387_immune_system_phenotype2.04464956
12MP0000465_gastrointestinal_hemorrhage1.99811277
13MP0004742_abnormal_vestibular_system1.97634642
14MP0002736_abnormal_nociception_after1.95884131
15MP0003866_abnormal_defecation1.94625152
16MP0004885_abnormal_endolymph1.86142504
17MP0005671_abnormal_response_to1.85847965
18MP0003011_delayed_dark_adaptation1.85774919
19MP0001800_abnormal_humoral_immune1.82555236
20MP0005000_abnormal_immune_tolerance1.79465529
21MP0005551_abnormal_eye_electrophysiolog1.72760258
22MP0001968_abnormal_touch/_nociception1.66246558
23MP0005332_abnormal_amino_acid1.62261026
24MP0003880_abnormal_central_pattern1.61198584
25MP0009785_altered_susceptibility_to1.58063749
26MP0004147_increased_porphyrin_level1.56110172
27MP0001501_abnormal_sleep_pattern1.54009337
28MP0009333_abnormal_splenocyte_physiolog1.53670333
29MP0001502_abnormal_circadian_rhythm1.53500360
30MP0002723_abnormal_immune_serum1.51300288
31MP0000372_irregular_coat_pigmentation1.48111200
32MP0009780_abnormal_chondrocyte_physiolo1.47142497
33MP0003724_increased_susceptibility_to1.38060406
34MP0002653_abnormal_ependyma_morphology1.36869719
35MP0008872_abnormal_physiological_respon1.36632467
36MP0003183_abnormal_peptide_metabolism1.36206326
37MP0002272_abnormal_nervous_system1.35249459
38MP0003806_abnormal_nucleotide_metabolis1.35137653
39MP0010155_abnormal_intestine_physiology1.33427445
40MP0001485_abnormal_pinna_reflex1.33283775
41MP0008875_abnormal_xenobiotic_pharmacok1.28086765
42MP0000427_abnormal_hair_cycle1.27848972
43MP0006276_abnormal_autonomic_nervous1.25575000
44MP0005360_urolithiasis1.24501272
45MP0002452_abnormal_antigen_presenting1.19314188
46MP0005025_abnormal_response_to1.19302512
47MP0005310_abnormal_salivary_gland1.19212079
48MP0001984_abnormal_olfaction1.18965179
49MP0003283_abnormal_digestive_organ1.18424887
50MP0004142_abnormal_muscle_tone1.17114556
51MP0003195_calcinosis1.16983784
52MP0005377_hearing/vestibular/ear_phenot1.16332383
53MP0003878_abnormal_ear_physiology1.16332383
54MP0003786_premature_aging1.15878021
55MP0006292_abnormal_olfactory_placode1.14905236
56MP0006054_spinal_hemorrhage1.13486858
57MP0009745_abnormal_behavioral_response1.12816191
58MP0001845_abnormal_inflammatory_respons1.11939268
59MP0002102_abnormal_ear_morphology1.10907904
60MP0003122_maternal_imprinting1.08931877
61MP0002229_neurodegeneration1.08508104
62MP0005084_abnormal_gallbladder_morpholo1.05326474
63MP0002277_abnormal_respiratory_mucosa1.04453664
64MP0002420_abnormal_adaptive_immunity1.03766671
65MP0005379_endocrine/exocrine_gland_phen1.03621935
66MP0001919_abnormal_reproductive_system1.02619736
67MP0001819_abnormal_immune_cell1.02497682
68MP0002184_abnormal_innervation1.00106183
69MP0001986_abnormal_taste_sensitivity0.98438568
70MP0002733_abnormal_thermal_nociception0.98008911
71MP0001853_heart_inflammation0.95540970
72MP0000230_abnormal_systemic_arterial0.94877516
73MP0002138_abnormal_hepatobiliary_system0.93877125
74MP0003252_abnormal_bile_duct0.91818991
75MP0008789_abnormal_olfactory_epithelium0.90773847
76MP0004043_abnormal_pH_regulation0.89904386
77MP0003638_abnormal_response/metabolism_0.87235929
78MP0003567_abnormal_fetal_cardiomyocyte0.87199931
79MP0005645_abnormal_hypothalamus_physiol0.86900124
80MP0005636_abnormal_mineral_homeostasis0.86193893
81MP0002876_abnormal_thyroid_physiology0.86170646
82MP0005389_reproductive_system_phenotype0.84674843
83MP0005167_abnormal_blood-brain_barrier0.84322441
84MP0005075_abnormal_melanosome_morpholog0.81018608
85MP0010329_abnormal_lipoprotein_level0.80441470
86MP0004145_abnormal_muscle_electrophysio0.79739178
87MP0006072_abnormal_retinal_apoptosis0.79428403
88MP0002572_abnormal_emotion/affect_behav0.79093192
89MP0008775_abnormal_heart_ventricle0.78663896
90MP0001765_abnormal_ion_homeostasis0.76391620
91MP0009643_abnormal_urine_homeostasis0.75886787
92MP0001440_abnormal_grooming_behavior0.74654971
93MP0001970_abnormal_pain_threshold0.73152791
94MP0000689_abnormal_spleen_morphology0.73056507
95MP0004264_abnormal_extraembryonic_tissu0.72956525
96MP0003633_abnormal_nervous_system0.71899089
97MP0002557_abnormal_social/conspecific_i0.71505299
98MP0002136_abnormal_kidney_physiology0.70804110
99MP0002398_abnormal_bone_marrow0.70753343
100MP0000534_abnormal_ureter_morphology0.70446365

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.28825577
2Methylmalonic acidemia (HP:0002912)4.92466937
3Congenital stationary night blindness (HP:0007642)4.46110728
4Abnormal ciliary motility (HP:0012262)4.43513414
5IgG deficiency (HP:0004315)4.41995740
6Methylmalonic aciduria (HP:0012120)4.34723482
7Increased IgM level (HP:0003496)4.33719175
8Renal cortical cysts (HP:0000803)4.30537587
9Cheilitis (HP:0100825)3.90127611
10Abnormality of the renal cortex (HP:0011035)3.64373880
11Papilledema (HP:0001085)3.64133695
12Hyperglycinemia (HP:0002154)3.34229491
13Abnormality of B cell number (HP:0010975)3.29853818
14Neutropenia (HP:0001875)3.24187628
15Short tibia (HP:0005736)3.20828632
16B lymphocytopenia (HP:0010976)3.18695790
17Abnormality of the vitamin B12 metabolism (HP:0004341)3.09689205
18Pulmonary infiltrates (HP:0002113)3.05548326
19Supernumerary bones of the axial skeleton (HP:0009144)3.04234405
20Type II lissencephaly (HP:0007260)3.03111230
21Absent thumb (HP:0009777)3.02536169
22Aplasia/Hypoplasia of the tibia (HP:0005772)3.00521258
23Abnormal respiratory motile cilium physiology (HP:0012261)2.97254357
24Xerostomia (HP:0000217)2.92641937
25Hypoplasia of the ulna (HP:0003022)2.92601627
26Abnormality of vitamin B metabolism (HP:0004340)2.89100336
27Conical tooth (HP:0000698)2.84456043
28Abnormality of T cell physiology (HP:0011840)2.70437771
29Nephronophthisis (HP:0000090)2.70366850
30Elevated erythrocyte sedimentation rate (HP:0003565)2.64254806
31Abnormal rod and cone electroretinograms (HP:0008323)2.60464414
32Type 2 muscle fiber atrophy (HP:0003554)2.59276717
33Aplasia/Hypoplasia of the ulna (HP:0006495)2.58538832
34Pancytopenia (HP:0001876)2.51285045
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49641639
36Dicarboxylic aciduria (HP:0003215)2.49641639
37Progressive inability to walk (HP:0002505)2.45828160
38Forearm undergrowth (HP:0009821)2.43386774
39Acute necrotizing encephalopathy (HP:0006965)2.35328036
40Hypoplasia of the fovea (HP:0007750)2.31983672
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.31983672
42Abolished electroretinogram (ERG) (HP:0000550)2.29379503
43Ketosis (HP:0001946)2.27541066
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25267255
45Abnormality of the renal medulla (HP:0100957)2.15225302
46Confusion (HP:0001289)2.14808998
47Abnormality of T cells (HP:0002843)2.14253979
48Inability to walk (HP:0002540)2.13117662
49Gonadotropin excess (HP:0000837)2.10520496
50Cerebellar dysplasia (HP:0007033)2.08358405
51Abnormality of macular pigmentation (HP:0008002)2.07234841
52Recurrent cutaneous fungal infections (HP:0011370)2.07012547
53Chronic mucocutaneous candidiasis (HP:0002728)2.07012547
54Delayed CNS myelination (HP:0002188)2.06468485
55Increased CSF lactate (HP:0002490)2.05396958
56Abnormal mitochondria in muscle tissue (HP:0008316)2.05023173
57Progressive macrocephaly (HP:0004481)2.04798971
58Mitochondrial inheritance (HP:0001427)2.04064242
59Stomach cancer (HP:0012126)2.00900995
60Hypoplasia of the radius (HP:0002984)2.00136156
61Panhypogammaglobulinemia (HP:0003139)1.99452240
62Ketoacidosis (HP:0001993)1.98793312
63Fibular hypoplasia (HP:0003038)1.98585310
64IgA deficiency (HP:0002720)1.98554238
65Abnormality of serine family amino acid metabolism (HP:0010894)1.98350298
66Abnormality of glycine metabolism (HP:0010895)1.98350298
67Lipid accumulation in hepatocytes (HP:0006561)1.98342625
68Muscle fiber atrophy (HP:0100295)1.98037165
69Pancreatic cysts (HP:0001737)1.97072949
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.95924798
71Acute encephalopathy (HP:0006846)1.95779799
72Hypertensive crisis (HP:0100735)1.92644356
73Pulmonary fibrosis (HP:0002206)1.89195353
74Bony spicule pigmentary retinopathy (HP:0007737)1.88795448
75Myokymia (HP:0002411)1.88631946
76Cleft eyelid (HP:0000625)1.88515042
77Abnormality of eosinophils (HP:0001879)1.85794937
78Abnormality of vitamin metabolism (HP:0100508)1.85741347
79Polyphagia (HP:0002591)1.84178846
80Molar tooth sign on MRI (HP:0002419)1.84059711
81Abnormality of midbrain morphology (HP:0002418)1.84059711
82Lethargy (HP:0001254)1.82782881
83Type I transferrin isoform profile (HP:0003642)1.81636184
84Increased serum lactate (HP:0002151)1.80379329
85Tubular atrophy (HP:0000092)1.79857507
86Abnormal drinking behavior (HP:0030082)1.78139024
87Polydipsia (HP:0001959)1.78139024
88Increased hepatocellular lipid droplets (HP:0006565)1.77853890
89Hypomagnesemia (HP:0002917)1.77051951
90Congenital, generalized hypertrichosis (HP:0004540)1.76994215
91Hypoproteinemia (HP:0003075)1.76667458
92Abnormality of the fovea (HP:0000493)1.76149392
93Hepatocellular necrosis (HP:0001404)1.72068023
94Rib fusion (HP:0000902)1.70777104
95IgM deficiency (HP:0002850)1.69937336
96Aplastic anemia (HP:0001915)1.69700468
97Respiratory difficulties (HP:0002880)1.67426284
983-Methylglutaconic aciduria (HP:0003535)1.66981989
99Hepatic necrosis (HP:0002605)1.66639918
100Myotonia (HP:0002486)1.65424628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.50541900
2TXK4.48946347
3NUAK13.24084317
4MAP2K23.20253061
5GRK53.03896066
6MAP4K13.01496007
7MAPKAPK32.86541556
8NME22.40496668
9GRK12.18333181
10EPHB12.10139869
11ZAK2.07113928
12ADRBK22.01708084
13NME11.94575433
14TRIM281.76503182
15DMPK1.71746176
16INSRR1.63397124
17DAPK11.59490199
18FRK1.54975586
19GRK61.54596832
20IRAK21.50869834
21MST41.48861058
22TEC1.39997044
23IKBKB1.35432813
24ITK1.33631448
25RPS6KA41.30626622
26FES1.22366553
27PHKG11.18524542
28PHKG21.18524542
29WNK41.15341653
30MAP2K61.13719645
31BMPR21.11089827
32TNIK1.03733053
33SIK31.03033685
34NEK91.01197612
35BRAF0.99974399
36SYK0.95917820
37SCYL20.95481062
38EIF2AK20.89588152
39PINK10.88137779
40PAK30.83747893
41TAF10.80483157
42PRKCG0.78185771
43VRK10.75435892
44BMPR1B0.74719913
45PNCK0.73949253
46WNK30.72826539
47RPS6KB10.72564514
48PIM10.63861373
49RPS6KA50.63249851
50MAPKAPK50.63092781
51VRK20.62558226
52GRK70.61107597
53DYRK20.60858209
54CAMK10.60143412
55ZAP700.57838614
56PRKCQ0.57665039
57BTK0.57147418
58BUB10.54808975
59LYN0.54420270
60KIT0.53932027
61LCK0.53760136
62RPS6KB20.51034021
63LATS10.50780866
64CAMK2D0.50578172
65IKBKE0.50032368
66TLK10.50019431
67IGF1R0.50003463
68OXSR10.48811221
69RPS6KA60.47278096
70STK160.46457837
71MAP2K10.45357135
72MAP3K140.44999550
73NEK10.44141770
74PRKG10.43112965
75IRAK40.42552317
76ADRBK10.41091627
77ATR0.40998687
78PLK30.40142547
79PLK20.39106759
80RPS6KA20.39091107
81PRKACA0.38259834
82MAPKAPK20.38132214
83TGFBR10.34974329
84HCK0.34715346
85EIF2AK30.33925534
86CSK0.33621436
87CHUK0.33440435
88MAP4K20.33314459
89OBSCN0.31604104
90STK38L0.30802326
91CAMK2A0.30052119
92RPS6KC10.29620629
93RPS6KL10.29620629
94CHEK20.29583240
95MAPK130.28453158
96TSSK60.28207510
97ERBB30.27960762
98PRKCA0.27405936
99WNK10.27404918
100TIE10.27189117

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.31019399
2Allograft rejection_Homo sapiens_hsa053303.16904627
3Autoimmune thyroid disease_Homo sapiens_hsa053202.92222181
4Linoleic acid metabolism_Homo sapiens_hsa005912.86590670
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.84385318
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.81706397
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68159999
8RNA polymerase_Homo sapiens_hsa030202.62163646
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.50926583
10Primary immunodeficiency_Homo sapiens_hsa053402.46588588
11Oxidative phosphorylation_Homo sapiens_hsa001902.44237122
12Ribosome_Homo sapiens_hsa030102.15758928
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12464649
14Protein export_Homo sapiens_hsa030602.06790913
15Graft-versus-host disease_Homo sapiens_hsa053322.06134393
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05803353
17T cell receptor signaling pathway_Homo sapiens_hsa046601.95638304
18Proteasome_Homo sapiens_hsa030501.95336663
19Type I diabetes mellitus_Homo sapiens_hsa049401.89083311
20Vitamin B6 metabolism_Homo sapiens_hsa007501.84094484
21Parkinsons disease_Homo sapiens_hsa050121.73492481
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67602619
23RNA degradation_Homo sapiens_hsa030181.63082240
24Cardiac muscle contraction_Homo sapiens_hsa042601.61871519
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53799393
26Olfactory transduction_Homo sapiens_hsa047401.53663536
27Nitrogen metabolism_Homo sapiens_hsa009101.35669237
28Pyrimidine metabolism_Homo sapiens_hsa002401.35549865
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.30117951
30Ether lipid metabolism_Homo sapiens_hsa005651.29964585
31Peroxisome_Homo sapiens_hsa041461.24597021
32Alzheimers disease_Homo sapiens_hsa050101.18961705
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18703773
34Phototransduction_Homo sapiens_hsa047441.18648586
35Sulfur relay system_Homo sapiens_hsa041221.17704709
36Huntingtons disease_Homo sapiens_hsa050161.17188869
37Basal transcription factors_Homo sapiens_hsa030221.13536906
38Morphine addiction_Homo sapiens_hsa050321.11971524
39Rheumatoid arthritis_Homo sapiens_hsa053231.06714736
40One carbon pool by folate_Homo sapiens_hsa006701.04114568
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03819536
42Nicotine addiction_Homo sapiens_hsa050331.03497943
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.02303459
44Arachidonic acid metabolism_Homo sapiens_hsa005901.01816640
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94169644
46Serotonergic synapse_Homo sapiens_hsa047260.93717541
47Retinol metabolism_Homo sapiens_hsa008300.92654327
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92431442
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91090349
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87873779
51Fat digestion and absorption_Homo sapiens_hsa049750.87748687
52Taste transduction_Homo sapiens_hsa047420.85592330
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.83166189
54Caffeine metabolism_Homo sapiens_hsa002320.80867471
55Tryptophan metabolism_Homo sapiens_hsa003800.79382938
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77539947
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76736144
58Sulfur metabolism_Homo sapiens_hsa009200.73281780
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.71317502
60Hematopoietic cell lineage_Homo sapiens_hsa046400.70855846
61Ovarian steroidogenesis_Homo sapiens_hsa049130.68393211
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65175317
63Chemokine signaling pathway_Homo sapiens_hsa040620.62448857
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61245709
65Collecting duct acid secretion_Homo sapiens_hsa049660.61022704
66Measles_Homo sapiens_hsa051620.60835719
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.59267996
68Vitamin digestion and absorption_Homo sapiens_hsa049770.58992098
69RNA transport_Homo sapiens_hsa030130.58692814
70Homologous recombination_Homo sapiens_hsa034400.57290741
71Purine metabolism_Homo sapiens_hsa002300.56658406
72Chemical carcinogenesis_Homo sapiens_hsa052040.55787305
73Mineral absorption_Homo sapiens_hsa049780.52923211
74Nucleotide excision repair_Homo sapiens_hsa034200.51054435
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49246838
76Selenocompound metabolism_Homo sapiens_hsa004500.49198906
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48711483
78GABAergic synapse_Homo sapiens_hsa047270.48703642
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48496987
80Fanconi anemia pathway_Homo sapiens_hsa034600.47405589
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47251005
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.46505610
83Viral myocarditis_Homo sapiens_hsa054160.45221385
84Metabolic pathways_Homo sapiens_hsa011000.44454109
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.44214989
86Arginine biosynthesis_Homo sapiens_hsa002200.40579162
87Insulin secretion_Homo sapiens_hsa049110.40543528
88Steroid biosynthesis_Homo sapiens_hsa001000.40117090
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39738256
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38970232
91Salivary secretion_Homo sapiens_hsa049700.38307750
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38300197
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37039498
94Butanoate metabolism_Homo sapiens_hsa006500.36679791
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35483241
96TNF signaling pathway_Homo sapiens_hsa046680.32722845
97Glutamatergic synapse_Homo sapiens_hsa047240.30495355
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30035496
99Oxytocin signaling pathway_Homo sapiens_hsa049210.28260647
100Regulation of autophagy_Homo sapiens_hsa041400.27357444

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