RPL23AP74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.15800436
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.84319317
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.82592174
4ATP synthesis coupled proton transport (GO:0015986)5.66264693
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.66264693
6DNA deamination (GO:0045006)5.49716601
7chaperone-mediated protein transport (GO:0072321)5.37399493
8ribosomal small subunit assembly (GO:0000028)5.27186109
9viral transcription (GO:0019083)4.59217099
10antigen processing and presentation via MHC class Ib (GO:0002475)4.45835052
11proteasome assembly (GO:0043248)4.43853126
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34847002
13translational termination (GO:0006415)4.32439699
14DNA strand renaturation (GO:0000733)4.16512914
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.05250143
16ribosomal small subunit biogenesis (GO:0042274)4.03339924
17respiratory electron transport chain (GO:0022904)4.02031885
18electron transport chain (GO:0022900)3.99945090
19cytidine deamination (GO:0009972)3.97967012
20cytidine metabolic process (GO:0046087)3.97967012
21cytidine catabolic process (GO:0006216)3.97967012
22translational elongation (GO:0006414)3.95884053
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.93830095
24cotranslational protein targeting to membrane (GO:0006613)3.86710916
25protein targeting to ER (GO:0045047)3.85735080
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.66189642
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63372958
28protein localization to endoplasmic reticulum (GO:0070972)3.63276559
29platelet dense granule organization (GO:0060155)3.55818625
30maturation of SSU-rRNA (GO:0030490)3.51533552
31protein complex biogenesis (GO:0070271)3.50630452
32ATP biosynthetic process (GO:0006754)3.45930810
33cellular response to interleukin-15 (GO:0071350)3.45443842
34protein-cofactor linkage (GO:0018065)3.34202573
35mast cell activation (GO:0045576)3.29797711
36viral life cycle (GO:0019058)3.27894151
37cellular protein complex disassembly (GO:0043624)3.21477852
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.18036742
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17804977
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17804977
41mitochondrial respiratory chain complex assembly (GO:0033108)3.17556181
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17051218
43termination of RNA polymerase III transcription (GO:0006386)3.14628324
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.14628324
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14561781
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.14561781
47NADH dehydrogenase complex assembly (GO:0010257)3.14561781
48positive regulation of antigen processing and presentation (GO:0002579)3.13236688
49hydrogen ion transmembrane transport (GO:1902600)3.11798894
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07281816
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.05448612
52translation (GO:0006412)3.01994389
53water-soluble vitamin biosynthetic process (GO:0042364)3.00704849
54translational initiation (GO:0006413)3.00396894
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00324636
56protein neddylation (GO:0045116)2.99351617
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98545993
58positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98332024
59intracellular protein transmembrane import (GO:0044743)2.97888382
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96864010
61positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92611070
62negative regulation of telomere maintenance (GO:0032205)2.92490198
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92079078
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91476922
65regulation of natural killer cell mediated immunity (GO:0002715)2.91476922
66regulation of antigen processing and presentation (GO:0002577)2.91283320
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91149683
68proton transport (GO:0015992)2.88025257
69positive regulation of natural killer cell mediated immunity (GO:0002717)2.87638441
70cytochrome complex assembly (GO:0017004)2.84498507
71hydrogen transport (GO:0006818)2.83347008
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80839515
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77652095
74adaptation of signaling pathway (GO:0023058)2.77462690
75T cell migration (GO:0072678)2.77143374
76regulation of chronic inflammatory response (GO:0002676)2.75211043
77antigen processing and presentation of endogenous antigen (GO:0019883)2.73746275
78regulation of cell killing (GO:0031341)2.73138802
79positive regulation of cell killing (GO:0031343)2.71291196
80regulation of T cell mediated cytotoxicity (GO:0001914)2.70805560
81regulation of isotype switching to IgG isotypes (GO:0048302)2.70756600
82pyrimidine nucleotide catabolic process (GO:0006244)2.68536216
83cellular component biogenesis (GO:0044085)2.68244232
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67149636
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66951718
86mannosylation (GO:0097502)2.66893243
87pseudouridine synthesis (GO:0001522)2.63765570
88positive regulation of prostaglandin secretion (GO:0032308)2.62870440
89regulation of cellular amino acid metabolic process (GO:0006521)2.60309619
90negative regulation of mast cell activation (GO:0033004)2.58402585
91peptidyl-histidine modification (GO:0018202)2.56690651
92protein polyglutamylation (GO:0018095)2.55142660
93respiratory chain complex IV assembly (GO:0008535)2.54047247
94rRNA modification (GO:0000154)2.51404249
95response to interleukin-15 (GO:0070672)2.50779326
96protein complex disassembly (GO:0043241)2.49403635
97ribonucleoprotein complex biogenesis (GO:0022613)2.48948133
98negative T cell selection (GO:0043383)2.47765313
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.47220029
100male meiosis (GO:0007140)2.44751634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.85476294
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69715186
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65843312
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.64705050
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52263615
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.48838719
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32819595
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16496137
9VDR_22108803_ChIP-Seq_LS180_Human2.88517470
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.87654395
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67590943
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62275788
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56663430
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51612702
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49622651
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.37660093
17VDR_23849224_ChIP-Seq_CD4+_Human2.30440967
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30303552
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.17152439
20ZNF274_21170338_ChIP-Seq_K562_Hela2.13729411
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.11098675
22IGF1R_20145208_ChIP-Seq_DFB_Human2.08653736
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91323871
24FOXP3_21729870_ChIP-Seq_TREG_Human1.88518117
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86916104
26ELK1_19687146_ChIP-ChIP_HELA_Human1.84860251
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78864035
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78706632
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.62310329
30TP53_22573176_ChIP-Seq_HFKS_Human1.58683867
31RUNX_20019798_ChIP-Seq_JUKART_Human1.53132969
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52982266
33GATA3_26560356_Chip-Seq_TH2_Human1.47530504
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44321271
35MYC_18940864_ChIP-ChIP_HL60_Human1.42425564
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.41324174
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.37982321
38MYB_26560356_Chip-Seq_TH2_Human1.36731661
39EZH2_22144423_ChIP-Seq_EOC_Human1.32955339
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30488307
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29212918
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.27650903
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27650903
44AR_20517297_ChIP-Seq_VCAP_Human1.27235455
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25780871
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24645021
47NANOG_20526341_ChIP-Seq_ESCs_Human1.23735145
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23370553
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.22613283
50IRF1_19129219_ChIP-ChIP_H3396_Human1.22264706
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20808514
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.20157862
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20069965
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19247978
55NCOR_22424771_ChIP-Seq_293T_Human1.17481349
56EWS_26573619_Chip-Seq_HEK293_Human1.17367570
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17070652
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14029999
59TAF2_19829295_ChIP-Seq_ESCs_Human1.12947370
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07104498
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.06376648
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06305478
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04449104
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04306889
65GATA6_21074721_ChIP-Seq_CACO-2_Human1.04235192
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04091386
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.04053659
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03702467
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03559417
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01436124
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00992818
72SOX2_19829295_ChIP-Seq_ESCs_Human1.00878708
73NANOG_19829295_ChIP-Seq_ESCs_Human1.00878708
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00427062
75CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98302674
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97580300
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96902096
78ERA_21632823_ChIP-Seq_H3396_Human0.96823246
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95599261
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94805277
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94759795
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94719295
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94062881
84RBPJ_21746931_ChIP-Seq_IB4_Human0.93557350
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.92702648
86BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92615542
87GATA3_27048872_Chip-Seq_THYMUS_Human0.91873657
88ERG_20517297_ChIP-Seq_VCAP_Human0.91556159
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.90076002
90TTF2_22483619_ChIP-Seq_HELA_Human0.88031698
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.86753076
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.86194887
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85906651
94CTCF_20526341_ChIP-Seq_ESCs_Human0.85904404
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85455466
96CBP_20019798_ChIP-Seq_JUKART_Human0.85455466
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85064808
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82888437
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82569991
100PHF8_20622853_ChIP-Seq_HELA_Human0.81727105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.92064243
2MP0001835_abnormal_antigen_presentation4.02594687
3MP0002102_abnormal_ear_morphology2.97218008
4MP0005377_hearing/vestibular/ear_phenot2.73604819
5MP0003878_abnormal_ear_physiology2.73604819
6MP0008995_early_reproductive_senescence2.62715525
7MP0000685_abnormal_immune_system2.60221556
8MP0009379_abnormal_foot_pigmentation2.57563427
9MP0002166_altered_tumor_susceptibility2.29944523
10MP0001790_abnormal_immune_system2.15430488
11MP0005387_immune_system_phenotype2.15430488
12MP0002876_abnormal_thyroid_physiology2.12409373
13MP0001800_abnormal_humoral_immune2.10121581
14MP0002163_abnormal_gland_morphology2.09597975
15MP0002148_abnormal_hypersensitivity_rea2.05453250
16MP0008875_abnormal_xenobiotic_pharmacok1.99465191
17MP0005000_abnormal_immune_tolerance1.98156259
18MP0009785_altered_susceptibility_to1.90104226
19MP0003786_premature_aging1.87152829
20MP0003763_abnormal_thymus_physiology1.86710366
21MP0008877_abnormal_DNA_methylation1.86328817
22MP0003866_abnormal_defecation1.86263265
23MP0006072_abnormal_retinal_apoptosis1.85288328
24MP0008872_abnormal_physiological_respon1.85213064
25MP0006292_abnormal_olfactory_placode1.83177583
26MP0002006_tumorigenesis1.82163978
27MP0009333_abnormal_splenocyte_physiolog1.81621632
28MP0002723_abnormal_immune_serum1.80404173
29MP0003646_muscle_fatigue1.75996037
30MP0004885_abnormal_endolymph1.74932116
31MP0000372_irregular_coat_pigmentation1.73358813
32MP0001873_stomach_inflammation1.70819616
33MP0002420_abnormal_adaptive_immunity1.70643112
34MP0001819_abnormal_immune_cell1.69539300
35MP0006082_CNS_inflammation1.59357266
36MP0002452_abnormal_antigen_presenting1.56821024
37MP0002138_abnormal_hepatobiliary_system1.52113710
38MP0005646_abnormal_pituitary_gland1.50820524
39MP0005025_abnormal_response_to1.47599241
40MP0005075_abnormal_melanosome_morpholog1.47280553
41MP0002837_dystrophic_cardiac_calcinosis1.46980198
42MP0005551_abnormal_eye_electrophysiolog1.41758927
43MP0004147_increased_porphyrin_level1.39875867
44MP0002736_abnormal_nociception_after1.38960923
45MP0002277_abnormal_respiratory_mucosa1.38860984
46MP0003195_calcinosis1.38757427
47MP0005645_abnormal_hypothalamus_physiol1.36753336
48MP0001919_abnormal_reproductive_system1.36720644
49MP0002933_joint_inflammation1.34368329
50MP0004142_abnormal_muscle_tone1.34159639
51MP0001968_abnormal_touch/_nociception1.33566898
52MP0001986_abnormal_taste_sensitivity1.31608239
53MP0000716_abnormal_immune_system1.29560488
54MP0003011_delayed_dark_adaptation1.29123986
55MP0005379_endocrine/exocrine_gland_phen1.27838386
56MP0004742_abnormal_vestibular_system1.26375579
57MP0002653_abnormal_ependyma_morphology1.26272930
58MP0002398_abnormal_bone_marrow1.23995081
59MP0010155_abnormal_intestine_physiology1.22952218
60MP0003806_abnormal_nucleotide_metabolis1.20538573
61MP0005389_reproductive_system_phenotype1.15401605
62MP0001845_abnormal_inflammatory_respons1.15332369
63MP0003436_decreased_susceptibility_to1.14936268
64MP0006036_abnormal_mitochondrial_physio1.10699394
65MP0005084_abnormal_gallbladder_morpholo1.06855545
66MP0002429_abnormal_blood_cell1.02147748
67MP0003724_increased_susceptibility_to1.01219888
68MP0004145_abnormal_muscle_electrophysio0.99016997
69MP0005253_abnormal_eye_physiology0.98432355
70MP0000689_abnormal_spleen_morphology0.98338232
71MP0001905_abnormal_dopamine_level0.98228968
72MP0000703_abnormal_thymus_morphology0.96861778
73MP0002722_abnormal_immune_system0.94990261
74MP0001485_abnormal_pinna_reflex0.94533832
75MP0009764_decreased_sensitivity_to0.90329821
76MP0002419_abnormal_innate_immunity0.89702902
77MP0005360_urolithiasis0.88059372
78MP0006276_abnormal_autonomic_nervous0.87316390
79MP0001119_abnormal_female_reproductive0.87235684
80MP0003879_abnormal_hair_cell0.83845129
81MP0003638_abnormal_response/metabolism_0.82805724
82MP0001501_abnormal_sleep_pattern0.82219430
83MP0003186_abnormal_redox_activity0.81421672
84MP0005636_abnormal_mineral_homeostasis0.81268583
85MP0008469_abnormal_protein_level0.79242267
86MP0001764_abnormal_homeostasis0.76765877
87MP0008058_abnormal_DNA_repair0.76601442
88MP0001765_abnormal_ion_homeostasis0.76508479
89MP0004019_abnormal_vitamin_homeostasis0.75339549
90MP0002405_respiratory_system_inflammati0.74516190
91MP0002693_abnormal_pancreas_physiology0.72744700
92MP0002160_abnormal_reproductive_system0.71977784
93MP0005332_abnormal_amino_acid0.71941750
94MP0001348_abnormal_lacrimal_gland0.71125543
95MP0005085_abnormal_gallbladder_physiolo0.69980160
96MP0009745_abnormal_behavioral_response0.68725716
97MP0001440_abnormal_grooming_behavior0.67148317
98MP0004381_abnormal_hair_follicle0.66286697
99MP0003137_abnormal_impulse_conducting0.65753172
100MP0001486_abnormal_startle_reflex0.64813505

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.45258590
2Reticulocytopenia (HP:0001896)4.05755644
3Mitochondrial inheritance (HP:0001427)3.98899636
4Elevated erythrocyte sedimentation rate (HP:0003565)3.96188215
5IgG deficiency (HP:0004315)3.93169311
6Abnormal mitochondria in muscle tissue (HP:0008316)3.80555323
7Progressive macrocephaly (HP:0004481)3.74040107
8Acute encephalopathy (HP:0006846)3.69475978
9Increased CSF lactate (HP:0002490)3.63147854
10Increased IgM level (HP:0003496)3.56447442
11Aplastic anemia (HP:0001915)3.53212674
12Increased hepatocellular lipid droplets (HP:0006565)3.44541966
13Lipid accumulation in hepatocytes (HP:0006561)3.39025706
143-Methylglutaconic aciduria (HP:0003535)3.29849220
15Abnormality of B cell number (HP:0010975)3.27243360
16Abnormality of T cell number (HP:0011839)3.23096288
17Chronic otitis media (HP:0000389)3.10337002
18Hepatocellular necrosis (HP:0001404)3.08559004
19Congenital stationary night blindness (HP:0007642)2.97267110
20Cerebral edema (HP:0002181)2.95203251
21Abnormality of the renal collecting system (HP:0004742)2.93752343
22Abnormality of T cells (HP:0002843)2.85231544
23Muscle fiber atrophy (HP:0100295)2.83675234
24Hypoproteinemia (HP:0003075)2.83604963
25T lymphocytopenia (HP:0005403)2.83584910
26Duplicated collecting system (HP:0000081)2.82377579
27Hepatic necrosis (HP:0002605)2.79722842
28Renal Fanconi syndrome (HP:0001994)2.78836092
29Renal cortical cysts (HP:0000803)2.76173475
30Stomatitis (HP:0010280)2.75223245
31Abnormality of DNA repair (HP:0003254)2.73835406
32Exertional dyspnea (HP:0002875)2.73268443
33Absent thumb (HP:0009777)2.70821555
34Chronic sinusitis (HP:0011109)2.69302520
35Oral leukoplakia (HP:0002745)2.69105150
36Congenital, generalized hypertrichosis (HP:0004540)2.66449251
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62983017
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62266840
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62266840
40Increased intramyocellular lipid droplets (HP:0012240)2.61402207
41Eosinophilia (HP:0001880)2.57338920
42Abnormal number of erythroid precursors (HP:0012131)2.53775176
43Abnormality of cells of the erythroid lineage (HP:0012130)2.52268091
44Abnormality of eosinophils (HP:0001879)2.50564517
45Nasal polyposis (HP:0100582)2.46370858
46Pancytopenia (HP:0001876)2.44641932
47Recurrent bronchitis (HP:0002837)2.43286160
48Respiratory difficulties (HP:0002880)2.39801351
49Optic disc pallor (HP:0000543)2.39167709
50Abnormality of the renal cortex (HP:0011035)2.38183614
51Increased muscle lipid content (HP:0009058)2.32924813
52Abolished electroretinogram (ERG) (HP:0000550)2.31984063
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31272926
54Autoimmune hemolytic anemia (HP:0001890)2.30952251
55Clubbing of toes (HP:0100760)2.30866689
56Pancreatic cysts (HP:0001737)2.28044605
57Pallor (HP:0000980)2.27748911
58Lactic acidosis (HP:0003128)2.27719527
59Increased serum lactate (HP:0002151)2.26912334
60Abnormality of T cell physiology (HP:0011840)2.25853787
61B lymphocytopenia (HP:0010976)2.25118704
62Methylmalonic acidemia (HP:0002912)2.16625308
63Abnormality of macular pigmentation (HP:0008002)2.12663009
64Autoimmune thrombocytopenia (HP:0001973)2.10284461
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09527891
66Severe combined immunodeficiency (HP:0004430)2.08591719
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02794906
68Abnormal rod and cone electroretinograms (HP:0008323)2.00060606
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.97663807
70Macrocytic anemia (HP:0001972)1.95987449
71Respiratory failure (HP:0002878)1.95448283
72Neutropenia (HP:0001875)1.95193279
73Type II lissencephaly (HP:0007260)1.94947814
74Lethargy (HP:0001254)1.93996762
75Stomach cancer (HP:0012126)1.93921488
76Bronchitis (HP:0012387)1.93105127
77Meckel diverticulum (HP:0002245)1.91978340
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91425999
79Abnormality of pyrimidine metabolism (HP:0004353)1.91051870
80Attenuation of retinal blood vessels (HP:0007843)1.91031992
81Abnormality of the ileum (HP:0001549)1.90289523
82Abnormality of midbrain morphology (HP:0002418)1.90258298
83Molar tooth sign on MRI (HP:0002419)1.90258298
84Abnormality of the nasal mucosa (HP:0000433)1.90035247
85Glycosuria (HP:0003076)1.89663845
86Abnormality of urine glucose concentration (HP:0011016)1.89663845
87Granulocytopenia (HP:0001913)1.89073335
88Methylmalonic aciduria (HP:0012120)1.88869859
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.88132166
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86757311
91Large eyes (HP:0001090)1.86320616
92Aplasia/hypoplasia of the uterus (HP:0008684)1.86004767
93Leukodystrophy (HP:0002415)1.84630196
94Chromsome breakage (HP:0040012)1.84352569
95Exercise intolerance (HP:0003546)1.82351998
96Joint swelling (HP:0001386)1.80337068
97IgM deficiency (HP:0002850)1.79798235
98Abnormality of renal resorption (HP:0011038)1.77464651
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77129091
100Thyroiditis (HP:0100646)1.75840408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.54111399
2TXK5.81396979
3MAP4K14.10428289
4MAP4K22.84945087
5TLK12.69014232
6BCKDK2.48642923
7ZAK2.41541592
8ADRBK22.19775719
9KDR2.05552533
10NUAK11.99132090
11GRK71.96420903
12VRK21.86770690
13GRK11.83678438
14GRK61.62314177
15WNK41.60056733
16PASK1.52291078
17CDK191.39624240
18PINK11.37007152
19ITK1.35565109
20FRK1.35509800
21MAP3K121.30249028
22IKBKB1.27490844
23NME11.26516956
24TESK21.25680655
25FES1.20941665
26SYK1.20101511
27VRK11.14412540
28MUSK1.12661024
29GRK51.12259531
30KIT1.11666329
31STK161.09190785
32NME21.04490334
33IKBKE1.03180317
34OXSR11.03020293
35BMPR20.99471057
36MST40.98955470
37MOS0.97718185
38LCK0.93007494
39TEC0.92761219
40CAMKK20.90114333
41TIE10.89209002
42LYN0.86016710
43TGFBR20.84069557
44INSRR0.76456666
45MYLK0.76217903
46WNK30.75035961
47ADRBK10.74942928
48PIM10.74072570
49EIF2AK20.73312489
50DAPK20.72207313
51PRKCQ0.71321756
52MAP2K20.69478113
53BTK0.68571898
54RPS6KA50.67291592
55EIF2AK30.67207960
56ZAP700.66884333
57BUB10.66756295
58DYRK20.66127428
59OBSCN0.64108048
60MATK0.62771822
61BMPR1B0.61648619
62HCK0.60959519
63CAMKK10.59121898
64TNK20.55976261
65PDK20.55532417
66IGF1R0.54758325
67CSF1R0.54657438
68DAPK10.53536672
69STK390.53340870
70JAK30.52091309
71CLK10.51235569
72SRPK10.49951778
73ACVR1B0.49294013
74TBK10.48551471
75MARK30.48093469
76STK100.44957899
77PIK3CG0.44166979
78PIK3CA0.42567618
79NEK10.41785076
80LIMK10.41309504
81RIPK40.40087805
82DAPK30.38821816
83PHKG10.38431358
84PHKG20.38431358
85PRKACA0.38309698
86ATR0.37166122
87CSNK2A10.36486510
88NLK0.35229139
89MAPK130.35161061
90CDK40.34378822
91MAP2K60.34286375
92PLK40.34185756
93EIF2AK10.33611389
94PRKCG0.33288494
95PRKCA0.33265452
96MAPKAPK30.32884586
97AURKB0.31781437
98CDK80.30754800
99CSNK2A20.29760097
100PRKCD0.29674843

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.14256543
2Oxidative phosphorylation_Homo sapiens_hsa001903.69628672
3Proteasome_Homo sapiens_hsa030503.33352587
4Primary immunodeficiency_Homo sapiens_hsa053403.28056797
5Parkinsons disease_Homo sapiens_hsa050122.99912553
6Allograft rejection_Homo sapiens_hsa053302.93623544
7Asthma_Homo sapiens_hsa053102.93532263
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.87586072
9Autoimmune thyroid disease_Homo sapiens_hsa053202.76963604
10Graft-versus-host disease_Homo sapiens_hsa053322.58172668
11RNA polymerase_Homo sapiens_hsa030202.28550351
12Type I diabetes mellitus_Homo sapiens_hsa049402.19550272
13Protein export_Homo sapiens_hsa030602.11373176
14Alzheimers disease_Homo sapiens_hsa050101.95095776
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91417702
16Huntingtons disease_Homo sapiens_hsa050161.90984834
17Antigen processing and presentation_Homo sapiens_hsa046121.89456188
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85468261
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73660042
20Cardiac muscle contraction_Homo sapiens_hsa042601.71083940
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68292223
22Phototransduction_Homo sapiens_hsa047441.56755952
23Basal transcription factors_Homo sapiens_hsa030221.46759196
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40559722
25Hematopoietic cell lineage_Homo sapiens_hsa046401.37201239
26Linoleic acid metabolism_Homo sapiens_hsa005911.36071217
27Homologous recombination_Homo sapiens_hsa034401.30543249
28One carbon pool by folate_Homo sapiens_hsa006701.22908049
29RNA degradation_Homo sapiens_hsa030181.20923141
30Rheumatoid arthritis_Homo sapiens_hsa053231.19233288
31Fanconi anemia pathway_Homo sapiens_hsa034601.14447105
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11715821
33Caffeine metabolism_Homo sapiens_hsa002321.09071867
34Pyrimidine metabolism_Homo sapiens_hsa002401.06503147
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03745353
36Nitrogen metabolism_Homo sapiens_hsa009101.00880482
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00245876
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96554571
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93807595
40Viral myocarditis_Homo sapiens_hsa054160.93276249
41Mismatch repair_Homo sapiens_hsa034300.92947482
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.90745121
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90713934
44Nucleotide excision repair_Homo sapiens_hsa034200.87707480
45Sulfur metabolism_Homo sapiens_hsa009200.86491443
46Purine metabolism_Homo sapiens_hsa002300.86431475
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85578609
48DNA replication_Homo sapiens_hsa030300.85536896
49Chemical carcinogenesis_Homo sapiens_hsa052040.85106188
50Spliceosome_Homo sapiens_hsa030400.82242542
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79455481
52T cell receptor signaling pathway_Homo sapiens_hsa046600.79230301
53Systemic lupus erythematosus_Homo sapiens_hsa053220.76107962
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74955143
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74346126
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72401555
57Propanoate metabolism_Homo sapiens_hsa006400.72170192
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.67490538
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66540170
60Staphylococcus aureus infection_Homo sapiens_hsa051500.66412612
61Retinol metabolism_Homo sapiens_hsa008300.65543385
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64948845
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.63173071
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61158587
65Tryptophan metabolism_Homo sapiens_hsa003800.58854104
66Herpes simplex infection_Homo sapiens_hsa051680.58753204
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58393410
68Olfactory transduction_Homo sapiens_hsa047400.55736053
69Mineral absorption_Homo sapiens_hsa049780.53503949
70Ether lipid metabolism_Homo sapiens_hsa005650.52130872
71Base excision repair_Homo sapiens_hsa034100.50176337
72Metabolic pathways_Homo sapiens_hsa011000.48810069
73Salivary secretion_Homo sapiens_hsa049700.48313887
74Pyruvate metabolism_Homo sapiens_hsa006200.47559749
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47143433
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47062295
77Peroxisome_Homo sapiens_hsa041460.44979631
78Leishmaniasis_Homo sapiens_hsa051400.43298650
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.43072229
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.42617314
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42239614
82Butanoate metabolism_Homo sapiens_hsa006500.41633084
83RNA transport_Homo sapiens_hsa030130.38689473
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38284181
85Collecting duct acid secretion_Homo sapiens_hsa049660.38171249
86ABC transporters_Homo sapiens_hsa020100.38125016
87Measles_Homo sapiens_hsa051620.37739497
88Malaria_Homo sapiens_hsa051440.37045371
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36617137
90Regulation of autophagy_Homo sapiens_hsa041400.35391244
91Fat digestion and absorption_Homo sapiens_hsa049750.34943017
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34880493
93Nicotine addiction_Homo sapiens_hsa050330.33633238
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.32233341
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32088480
96Vitamin digestion and absorption_Homo sapiens_hsa049770.31509137
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31369901
98beta-Alanine metabolism_Homo sapiens_hsa004100.28302643
99Taste transduction_Homo sapiens_hsa047420.27684909
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.24558809

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