ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	7.35170447
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.17711424
3	ATP synthesis coupled proton transport (GO:0015986)	6.17711424
4	viral transcription (GO:0019083)	6.04792504
5	chaperone-mediated protein transport (GO:0072321)	6.00964260
6	translational termination (GO:0006415)	5.75744628
7	DNA deamination (GO:0045006)	5.58515761
8	translational elongation (GO:0006414)	5.18857172
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.17069033
10	ribosomal small subunit assembly (GO:0000028)	5.15512739
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.10202940
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.05150326
13	cotranslational protein targeting to membrane (GO:0006613)	4.99265930
14	protein targeting to ER (GO:0045047)	4.96964315
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.75955580
16	protein localization to endoplasmic reticulum (GO:0070972)	4.69793317
17	viral life cycle (GO:0019058)	4.40309084
18	cellular protein complex disassembly (GO:0043624)	4.36774904
19	ribosomal large subunit biogenesis (GO:0042273)	4.36349324
20	respiratory electron transport chain (GO:0022904)	4.34555447
21	electron transport chain (GO:0022900)	4.28455595
22	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.20173248
23	ribonucleoprotein complex biogenesis (GO:0022613)	4.02459566
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.98717925
25	GDP-mannose metabolic process (GO:0019673)	3.94873289
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.87991310
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.87991310
28	translational initiation (GO:0006413)	3.82060307
29	cellular component biogenesis (GO:0044085)	3.76508218
30	maturation of SSU-rRNA (GO:0030490)	3.72076732
31	translation (GO:0006412)	3.66849853
32	nucleoside transmembrane transport (GO:1901642)	3.64294569
33	ATP biosynthetic process (GO:0006754)	3.62538067
34	regulation of cellular respiration (GO:0043457)	3.55826959
35	response to pheromone (GO:0019236)	3.54090604
36	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.47487056
37	protein complex disassembly (GO:0043241)	3.45756087
38	protein targeting to membrane (GO:0006612)	3.42066884
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.40919297
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.36365965
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.32796709
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.29070970
43	cytidine deamination (GO:0009972)	3.26697399
44	cytidine metabolic process (GO:0046087)	3.26697399
45	cytidine catabolic process (GO:0006216)	3.26697399
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23808856
47	macromolecular complex disassembly (GO:0032984)	3.21298123
48	hydrogen ion transmembrane transport (GO:1902600)	3.20160638
49	interferon-gamma production (GO:0032609)	3.19426346
50	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.17811114
51	respiratory chain complex IV assembly (GO:0008535)	3.11064931
52	NADH dehydrogenase complex assembly (GO:0010257)	3.08975448
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.08975448
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.08975448
55	protein complex biogenesis (GO:0070271)	3.08271817
56	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.04464829
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.03822604
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.02829278
59	mast cell activation (GO:0045576)	3.02806267
60	proton transport (GO:0015992)	2.98220703
61	protein neddylation (GO:0045116)	2.98210318
62	negative regulation of heart rate (GO:0010459)	2.95715609
63	regulation of immunoglobulin secretion (GO:0051023)	2.93485657
64	hydrogen transport (GO:0006818)	2.92536451
65	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.85450411
66	mRNA catabolic process (GO:0006402)	2.84326784
67	regulation of isotype switching to IgG isotypes (GO:0048302)	2.83194863
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.83073233
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.81917370
70	regulation of hypersensitivity (GO:0002883)	2.81428916
71	tolerance induction (GO:0002507)	2.80920665
72	rRNA modification (GO:0000154)	2.80655732
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79252473
74	regulation of regulatory T cell differentiation (GO:0045589)	2.78722584
75	regulation of chronic inflammatory response (GO:0002676)	2.77844362
76	ribosome biogenesis (GO:0042254)	2.77215555
77	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.74747004
78	cytochrome complex assembly (GO:0017004)	2.73488237
79	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.69528432
80	rRNA processing (GO:0006364)	2.69475410
81	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.67944308
82	ncRNA 3-end processing (GO:0043628)	2.67444591
83	rRNA metabolic process (GO:0016072)	2.65446273
84	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.64814658
85	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.64156083
86	termination of RNA polymerase III transcription (GO:0006386)	2.64156083
87	RNA catabolic process (GO:0006401)	2.59767657
88	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.58272317
89	positive regulation of B cell mediated immunity (GO:0002714)	2.58272317
90	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.55648376
91	mast cell activation involved in immune response (GO:0002279)	2.51844857
92	mast cell degranulation (GO:0043303)	2.51844857
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.50800070
94	intracellular protein transmembrane import (GO:0044743)	2.50394416
95	GMP metabolic process (GO:0046037)	2.49864368
96	reproduction (GO:0000003)	2.49409468
97	regulation of T cell mediated cytotoxicity (GO:0001914)	2.47570305
98	nucleoside transport (GO:0015858)	2.47500112
99	NADH metabolic process (GO:0006734)	2.41142696
100	regulation of energy homeostasis (GO:2000505)	2.38795655

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	8.66725564
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61524888
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.23685691
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18634555
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.08316073
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89910141
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80773106
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.75395862
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40618183
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38291924
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.31110622
12	VDR_22108803_ChIP-Seq_LS180_Human	2.23682657
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23255058
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.21570013
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.96164929
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.90576719
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84809177
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.74203650
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71023071
20	EZH2_22144423_ChIP-Seq_EOC_Human	1.68698117
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.64929692
22	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.53910739
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.49764844
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48284668
25	GATA3_26560356_Chip-Seq_TH2_Human	1.42857448
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.42605880
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39480201
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39384364
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38332451
30	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37507860
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.34486187
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34105832
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34105832
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33742730
35	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.33709918
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32377092
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31907456
38	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.30604795
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.30518590
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29185513
41	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.26310651
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26229635
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25520131
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25131810
45	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.24877138
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23571842
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23505112
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22218932
49	NCOR_22424771_ChIP-Seq_293T_Human	1.21565617
50	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21148447
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18966324
52	MYC_19829295_ChIP-Seq_ESCs_Human	1.18044263
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17301016
54	BCL6_27268052_Chip-Seq_Bcells_Human	1.15484969
55	AR_20517297_ChIP-Seq_VCAP_Human	1.14328103
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.14129310
57	FUS_26573619_Chip-Seq_HEK293_Human	1.13884585
58	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13259182
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13213011
60	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12983581
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12013489
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.11749555
63	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.11231024
64	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11006742
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10822736
66	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.10715629
67	SA1_27219007_Chip-Seq_Bcells_Human	1.10639060
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09862085
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.09056189
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08635983
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07403301
72	EGR1_19032775_ChIP-ChIP_M12_Human	1.06942701
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.06879565
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04647951
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04637109
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03436920
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03410951
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03341113
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03341113
80	MYB_26560356_Chip-Seq_TH2_Human	1.02722884
81	STAT1_20625510_ChIP-Seq_HELA_Human	0.99315257
82	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.98293291
83	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97330370
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97121143
85	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96792713
86	ERA_21632823_ChIP-Seq_H3396_Human	0.96496239
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96193719
88	P300_27268052_Chip-Seq_Bcells_Human	0.96120522
89	E2F1_20622854_ChIP-Seq_HELA_Human	0.96016724
90	EWS_26573619_Chip-Seq_HEK293_Human	0.95103490
91	TAF15_26573619_Chip-Seq_HEK293_Human	0.94653044
92	GATA3_27048872_Chip-Seq_THYMUS_Human	0.94204138
93	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93937475
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93781407
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.93591655
96	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.92518280
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91789099
98	TTF2_22483619_ChIP-Seq_HELA_Human	0.91582985
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91460362
100	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91309667

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.07603393
2	MP0005671_abnormal_response_to	3.74897972
3	MP0001835_abnormal_antigen_presentation	3.74344477
4	MP0001873_stomach_inflammation	2.81118720
5	MP0009785_altered_susceptibility_to	2.69237666
6	MP0002837_dystrophic_cardiac_calcinosis	2.38258631
7	MP0002163_abnormal_gland_morphology	2.35463642
8	MP0006082_CNS_inflammation	2.35425295
9	MP0009333_abnormal_splenocyte_physiolog	2.31732351
10	MP0003646_muscle_fatigue	2.26323560
11	MP0005387_immune_system_phenotype	2.24665776
12	MP0001790_abnormal_immune_system	2.24665776
13	MP0001800_abnormal_humoral_immune	2.22196183
14	MP0006072_abnormal_retinal_apoptosis	2.06333989
15	MP0008875_abnormal_xenobiotic_pharmacok	2.05921460
16	MP0000685_abnormal_immune_system	2.05089242
17	MP0002148_abnormal_hypersensitivity_rea	1.99360534
18	MP0003806_abnormal_nucleotide_metabolis	1.93956447
19	MP0001986_abnormal_taste_sensitivity	1.89362664
20	MP0005000_abnormal_immune_tolerance	1.86090112
21	MP0000372_irregular_coat_pigmentation	1.84520717
22	MP0010155_abnormal_intestine_physiology	1.82562201
23	MP0003724_increased_susceptibility_to	1.71695638
24	MP0006292_abnormal_olfactory_placode	1.71258682
25	MP0003436_decreased_susceptibility_to	1.70092625
26	MP0008872_abnormal_physiological_respon	1.69682852
27	MP0009764_decreased_sensitivity_to	1.67122989
28	MP0002723_abnormal_immune_serum	1.65661804
29	MP0003195_calcinosis	1.64836866
30	MP0005377_hearing/vestibular/ear_phenot	1.63532478
31	MP0003878_abnormal_ear_physiology	1.63532478
32	MP0003879_abnormal_hair_cell	1.59459306
33	MP0005379_endocrine/exocrine_gland_phen	1.57974307
34	MP0002638_abnormal_pupillary_reflex	1.55814964
35	MP0005360_urolithiasis	1.54076120
36	MP0005646_abnormal_pituitary_gland	1.52713505
37	MP0002452_abnormal_antigen_presenting	1.49486992
38	MP0002876_abnormal_thyroid_physiology	1.48496066
39	MP0004145_abnormal_muscle_electrophysio	1.43738606
40	MP0005025_abnormal_response_to	1.42488682
41	MP0001501_abnormal_sleep_pattern	1.41186599
42	MP0002420_abnormal_adaptive_immunity	1.39700247
43	MP0001819_abnormal_immune_cell	1.38409871
44	MP0005645_abnormal_hypothalamus_physiol	1.37842798
45	MP0004147_increased_porphyrin_level	1.36899013
46	MP0002933_joint_inflammation	1.36019342
47	MP0005410_abnormal_fertilization	1.34724303
48	MP0003866_abnormal_defecation	1.33952157
49	MP0005075_abnormal_melanosome_morpholog	1.32613157
50	MP0001727_abnormal_embryo_implantation	1.31021701
51	MP0001905_abnormal_dopamine_level	1.27751430
52	MP0001845_abnormal_inflammatory_respons	1.27188977
53	MP0002138_abnormal_hepatobiliary_system	1.22652187
54	MP0004510_myositis	1.20709417
55	MP0006036_abnormal_mitochondrial_physio	1.19266566
56	MP0001968_abnormal_touch/_nociception	1.18292448
57	MP0002277_abnormal_respiratory_mucosa	1.18192492
58	MP0003763_abnormal_thymus_physiology	1.14932324
59	MP0005636_abnormal_mineral_homeostasis	1.14162919
60	MP0002736_abnormal_nociception_after	1.11746468
61	MP0002405_respiratory_system_inflammati	1.10491613
62	MP0004142_abnormal_muscle_tone	1.10484374
63	MP0002398_abnormal_bone_marrow	1.10338162
64	MP0001765_abnormal_ion_homeostasis	1.07684664
65	MP0001348_abnormal_lacrimal_gland	1.06101515
66	MP0000716_abnormal_immune_system	1.04036508
67	MP0003011_delayed_dark_adaptation	1.03555593
68	MP0002095_abnormal_skin_pigmentation	1.02925093
69	MP0000678_abnormal_parathyroid_gland	1.02445790
70	MP0005389_reproductive_system_phenotype	1.01349909
71	MP0005551_abnormal_eye_electrophysiolog	1.01127343
72	MP0004885_abnormal_endolymph	1.00397069
73	MP0001533_abnormal_skeleton_physiology	1.00067205
74	MP0005332_abnormal_amino_acid	0.99977529
75	MP0005085_abnormal_gallbladder_physiolo	0.99565564
76	MP0001663_abnormal_digestive_system	0.99503314
77	MP0001919_abnormal_reproductive_system	0.98768569
78	MP0002160_abnormal_reproductive_system	0.96484947
79	MP0002419_abnormal_innate_immunity	0.95383439
80	MP0008469_abnormal_protein_level	0.91918067
81	MP0000689_abnormal_spleen_morphology	0.90589815
82	MP0002653_abnormal_ependyma_morphology	0.90371811
83	MP0002166_altered_tumor_susceptibility	0.88737270
84	MP0003718_maternal_effect	0.88595362
85	MP0004019_abnormal_vitamin_homeostasis	0.87700307
86	MP0002429_abnormal_blood_cell	0.83143871
87	MP0001764_abnormal_homeostasis	0.83058694
88	MP0003252_abnormal_bile_duct	0.82949308
89	MP0005253_abnormal_eye_physiology	0.82817301
90	MP0004742_abnormal_vestibular_system	0.82565286
91	MP0005174_abnormal_tail_pigmentation	0.79106415
92	MP0002722_abnormal_immune_system	0.78571560
93	MP0002102_abnormal_ear_morphology	0.78343170
94	MP0009765_abnormal_xenobiotic_induced	0.78219132
95	MP0009745_abnormal_behavioral_response	0.77538343
96	MP0002693_abnormal_pancreas_physiology	0.77387163
97	MP0001881_abnormal_mammary_gland	0.76973744
98	MP0001853_heart_inflammation	0.75209155
99	MP0002272_abnormal_nervous_system	0.71547549
100	MP0003186_abnormal_redox_activity	0.70125488

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.81317866
2	Mitochondrial inheritance (HP:0001427)	4.47651837
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.22302042
4	Increased CSF lactate (HP:0002490)	4.16702778
5	Progressive macrocephaly (HP:0004481)	4.00799418
6	Increased hepatocellular lipid droplets (HP:0006565)	3.97466936
7	Acute encephalopathy (HP:0006846)	3.94389049
8	Hepatocellular necrosis (HP:0001404)	3.75484480
9	Lipid accumulation in hepatocytes (HP:0006561)	3.71002789
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.57547993
11	Renal Fanconi syndrome (HP:0001994)	3.44410655
12	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.36995975
13	Constricted visual fields (HP:0001133)	3.31246835
14	Hepatic necrosis (HP:0002605)	3.27023919
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.19246146
16	Abnormality of macular pigmentation (HP:0008002)	3.16813592
17	Optic disc pallor (HP:0000543)	3.07103657
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.06517055
19	Increased intramyocellular lipid droplets (HP:0012240)	3.05646574
20	Attenuation of retinal blood vessels (HP:0007843)	3.05490568
21	Exertional dyspnea (HP:0002875)	3.03515266
22	Stomatitis (HP:0010280)	3.02073766
23	IgG deficiency (HP:0004315)	2.99586128
24	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.96107990
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.96107990
26	Macrocytic anemia (HP:0001972)	2.91949853
27	Abnormal number of erythroid precursors (HP:0012131)	2.88265629
28	Methylmalonic acidemia (HP:0002912)	2.88022567
29	Cerebral edema (HP:0002181)	2.87521713
30	3-Methylglutaconic aciduria (HP:0003535)	2.87362413
31	Congenital, generalized hypertrichosis (HP:0004540)	2.85423293
32	Congenital stationary night blindness (HP:0007642)	2.80980204
33	Absent/shortened dynein arms (HP:0200106)	2.80099138
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.80099138
35	Global brain atrophy (HP:0002283)	2.73475863
36	Increased muscle lipid content (HP:0009058)	2.64287138
37	Increased serum lactate (HP:0002151)	2.57898689
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54047198
39	Leukodystrophy (HP:0002415)	2.52044180
40	Lactic acidosis (HP:0003128)	2.41472978
41	Dyskinesia (HP:0100660)	2.38693260
42	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38197861
43	Hypoproteinemia (HP:0003075)	2.36082675
44	Abnormality of urine glucose concentration (HP:0011016)	2.33388355
45	Glycosuria (HP:0003076)	2.33388355
46	Methylmalonic aciduria (HP:0012120)	2.33275766
47	Hyperphosphaturia (HP:0003109)	2.29252122
48	Pallor (HP:0000980)	2.25364064
49	Abnormality of renal resorption (HP:0011038)	2.20514138
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.16893180
51	Hyperglycinemia (HP:0002154)	2.14845939
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.12462930
53	Decreased muscle mass (HP:0003199)	2.11641407
54	Respiratory failure (HP:0002878)	2.10752218
55	Abnormality of vitamin B metabolism (HP:0004340)	2.09148922
56	Respiratory difficulties (HP:0002880)	2.07053330
57	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.06924896
58	Lethargy (HP:0001254)	2.06872694
59	Microretrognathia (HP:0000308)	2.06770312
60	Myositis (HP:0100614)	2.06146714
61	Hypoplasia of the pons (HP:0012110)	2.03337398
62	Reticulocytopenia (HP:0001896)	2.01454501
63	Abnormality of the pons (HP:0007361)	1.99411905
64	Testicular atrophy (HP:0000029)	1.98112694
65	Abnormality of magnesium homeostasis (HP:0004921)	1.94955115
66	Hypobetalipoproteinemia (HP:0003563)	1.93693367
67	Orchitis (HP:0100796)	1.93588056
68	Chronic diarrhea (HP:0002028)	1.91530314
69	B lymphocytopenia (HP:0010976)	1.90659170
70	Akinesia (HP:0002304)	1.89870452
71	Renal tubular dysfunction (HP:0000124)	1.88523742
72	Molar tooth sign on MRI (HP:0002419)	1.86777982
73	Abnormality of midbrain morphology (HP:0002418)	1.86777982
74	Exercise intolerance (HP:0003546)	1.86200271
75	Abnormality of B cell number (HP:0010975)	1.85328916
76	Type II lissencephaly (HP:0007260)	1.85099085
77	Abnormality of T cells (HP:0002843)	1.84474324
78	Hypomagnesemia (HP:0002917)	1.82240822
79	Retrobulbar optic neuritis (HP:0100654)	1.80751998
80	Optic neuritis (HP:0100653)	1.80751998
81	CNS demyelination (HP:0007305)	1.80705579
82	Generalized aminoaciduria (HP:0002909)	1.80520034
83	Type 2 muscle fiber atrophy (HP:0003554)	1.80500100
84	Tetany (HP:0001281)	1.77833719
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77627639
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.77627639
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77260934
88	Decreased central vision (HP:0007663)	1.77002941
89	Patent foramen ovale (HP:0001655)	1.76599855
90	Abnormality of alanine metabolism (HP:0010916)	1.75647323
91	Hyperalaninemia (HP:0003348)	1.75647323
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75647323
93	Brushfield spots (HP:0001088)	1.74506472
94	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.74431753
95	Round ear (HP:0100830)	1.74302928
96	Emotional lability (HP:0000712)	1.74230032
97	Abnormal ciliary motility (HP:0012262)	1.74098553
98	Severe combined immunodeficiency (HP:0004430)	1.73256949
99	Cleft eyelid (HP:0000625)	1.72601884
100	Abnormality of serum amino acid levels (HP:0003112)	1.72399638

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.90464541
2	TXK	3.67583680
3	PASK	3.39000655
4	KIT	3.14580094
5	MAP4K1	2.87138658
6	ZAK	2.75641437
7	BMPR2	2.66001476
8	TEC	2.35478634
9	MAP4K2	2.20934809
10	RIPK4	2.14919250
11	FES	2.09227691
12	MAP3K12	2.04923252
13	CDK19	2.01757034
14	ADRBK2	1.98433480
15	TAOK3	1.92471896
16	IKBKB	1.83140273
17	NME2	1.81017231
18	MAP2K6	1.70120832
19	WNK4	1.69226731
20	GRK1	1.68880962
21	SYK	1.59552215
22	SCYL2	1.58732229
23	MYLK	1.55487885
24	KDR	1.49092128
25	INSRR	1.46836060
26	GRK6	1.45017857
27	BCKDK	1.34978871
28	PDK2	1.33672453
29	NUAK1	1.29574055
30	OXSR1	1.29126440
31	CAMKK1	1.26215185
32	CAMKK2	1.24386663
33	PLK4	1.22533620
34	FRK	1.19319701
35	ITK	1.19276357
36	BMPR1B	1.18341733
37	LCK	1.12937413
38	CSF1R	1.11110087
39	TESK2	1.09350926
40	BTK	1.02118156
41	STK16	0.98031247
42	MST4	0.95719202
43	LYN	0.94908836
44	MAP3K13	0.93669365
45	TSSK6	0.92214511
46	IKBKE	0.91162800
47	WNK3	0.89314953
48	PIK3CG	0.88469281
49	JAK3	0.88065747
50	ZAP70	0.84325198
51	TIE1	0.84140010
52	MAP3K14	0.83429584
53	OBSCN	0.79769478
54	MUSK	0.76417237
55	GRK7	0.76136260
56	ADRBK1	0.75936502
57	SIK2	0.75721418
58	PINK1	0.75110150
59	PRKCQ	0.71605773
60	STK39	0.68255640
61	RPS6KA5	0.67619611
62	CDK8	0.65400138
63	PIM1	0.62499184
64	TRPM7	0.61493918
65	VRK1	0.61320914
66	ERBB3	0.59259088
67	BUB1	0.56661033
68	DYRK2	0.56540802
69	LRRK2	0.55081540
70	MAP2K2	0.53122294
71	VRK2	0.52850753
72	PRKCA	0.52022039
73	MATK	0.51922587
74	CSK	0.51592182
75	IGF1R	0.51237558
76	ABL2	0.48955374
77	PRKACA	0.48832634
78	ILK	0.48758625
79	NME1	0.47796433
80	PHKG1	0.45634680
81	PHKG2	0.45634680
82	CSNK2A1	0.44082340
83	DAPK1	0.42325097
84	CSNK2A2	0.41951793
85	ABL1	0.39640295
86	PKN1	0.38822074
87	CAMK2A	0.38113637
88	MAPK15	0.37271172
89	PRKCD	0.36355003
90	PRKCG	0.35664052
91	INSR	0.35406550
92	FLT3	0.35174455
93	DAPK3	0.35064224
94	NEK2	0.32801494
95	PRKACG	0.32300908
96	NEK1	0.32289258
97	PRKG1	0.27366620
98	EGFR	0.27125028
99	PRKCE	0.24427106
100	TYRO3	0.23903974

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.63251104
2	Asthma_Homo sapiens_hsa05310	4.20855592
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.75888205
4	Allograft rejection_Homo sapiens_hsa05330	3.60634032
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.45873264
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.25141458
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.05827397
8	Parkinsons disease_Homo sapiens_hsa05012	2.99214302
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.89731521
10	Proteasome_Homo sapiens_hsa03050	2.83530893
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.19854267
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11815154
13	Alzheimers disease_Homo sapiens_hsa05010	2.06977450
14	Sulfur metabolism_Homo sapiens_hsa00920	2.05851035
15	Huntingtons disease_Homo sapiens_hsa05016	1.91024880
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.75983101
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.75332873
18	RNA polymerase_Homo sapiens_hsa03020	1.59628344
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52438873
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48372447
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45342175
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44021016
23	Phototransduction_Homo sapiens_hsa04744	1.42418059
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.36311430
25	Viral myocarditis_Homo sapiens_hsa05416	1.35519979
26	Protein export_Homo sapiens_hsa03060	1.34354649
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32378733
28	One carbon pool by folate_Homo sapiens_hsa00670	1.30850111
29	Caffeine metabolism_Homo sapiens_hsa00232	1.24824408
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.24072157
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14330275
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14236568
33	RNA degradation_Homo sapiens_hsa03018	1.11942077
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.04648565
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.98300416
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.95548192
37	Leishmaniasis_Homo sapiens_hsa05140	0.94251001
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93580220
39	Homologous recombination_Homo sapiens_hsa03440	0.85414930
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84726566
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83182803
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.82908879
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.82857105
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.79989462
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79386325
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74374469
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73162122
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72634923
49	Mismatch repair_Homo sapiens_hsa03430	0.70918208
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70191873
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68889453
52	Purine metabolism_Homo sapiens_hsa00230	0.66665188
53	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64867244
54	Olfactory transduction_Homo sapiens_hsa04740	0.62784776
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62054820
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60044059
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.58425471
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.58149663
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56939085
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56003637
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54256846
62	Retinol metabolism_Homo sapiens_hsa00830	0.53681235
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.53222925
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52824212
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51189290
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50373173
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49607682
68	Metabolic pathways_Homo sapiens_hsa01100	0.48759485
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45335803
70	Peroxisome_Homo sapiens_hsa04146	0.41216505
71	Regulation of autophagy_Homo sapiens_hsa04140	0.40422678
72	DNA replication_Homo sapiens_hsa03030	0.39598512
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.39247553
74	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36415323
75	Glutathione metabolism_Homo sapiens_hsa00480	0.36275069
76	Nicotine addiction_Homo sapiens_hsa05033	0.36225105
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36183294
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33183685
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.32510963
80	Basal transcription factors_Homo sapiens_hsa03022	0.31438490
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31283447
82	Herpes simplex infection_Homo sapiens_hsa05168	0.29368294
83	Spliceosome_Homo sapiens_hsa03040	0.26790762
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26749698
85	Toxoplasmosis_Homo sapiens_hsa05145	0.25769554
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25589444
87	Measles_Homo sapiens_hsa05162	0.24983292
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.23808938
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.23329037
90	Taste transduction_Homo sapiens_hsa04742	0.23244754
91	Histidine metabolism_Homo sapiens_hsa00340	0.22867506
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22080868
93	Mineral absorption_Homo sapiens_hsa04978	0.21930131
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.21864181
95	Fanconi anemia pathway_Homo sapiens_hsa03460	0.21053087
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.20414602
97	Morphine addiction_Homo sapiens_hsa05032	0.19130640
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.18350003
99	Tuberculosis_Homo sapiens_hsa05152	0.15411633
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.15222735

RPL23AP75

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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