ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	7.79226638
2	viral transcription (GO:0019083)	7.09283430
3	translational termination (GO:0006415)	6.80124294
4	chaperone-mediated protein transport (GO:0072321)	6.69126110
5	ribosomal small subunit biogenesis (GO:0042274)	6.35708608
6	positive regulation of signal transduction by p53 class mediator (GO:1901798)	6.12836804
7	translational elongation (GO:0006414)	5.80744757
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.78666607
9	cotranslational protein targeting to membrane (GO:0006613)	5.72518245
10	protein targeting to ER (GO:0045047)	5.70707162
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.41904173
12	DNA deamination (GO:0045006)	5.40602431
13	ribosomal small subunit assembly (GO:0000028)	5.30393351
14	protein localization to endoplasmic reticulum (GO:0070972)	5.28803580
15	viral life cycle (GO:0019058)	5.14419178
16	ATP synthesis coupled proton transport (GO:0015986)	5.08131220
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.08131220
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.07763086
19	activation of MAPKKK activity (GO:0000185)	5.06333599
20	cellular protein complex disassembly (GO:0043624)	5.01305380
21	leukocyte aggregation (GO:0070486)	4.91068988
22	positive regulation of prostaglandin secretion (GO:0032308)	4.79737696
23	translational initiation (GO:0006413)	4.74109658
24	erythrocyte maturation (GO:0043249)	4.45956183
25	maturation of 5.8S rRNA (GO:0000460)	4.37970584
26	pseudouridine synthesis (GO:0001522)	4.20476777
27	nucleoside transmembrane transport (GO:1901642)	4.20235191
28	regulation of regulatory T cell differentiation (GO:0045589)	4.19481989
29	behavioral response to nicotine (GO:0035095)	4.12860505
30	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.11014076
31	regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)	4.02530028
32	positive regulation of fatty acid transport (GO:2000193)	4.02059167
33	protein complex disassembly (GO:0043241)	4.00310539
34	protein targeting to membrane (GO:0006612)	3.95536925
35	positive regulation of translational initiation (GO:0045948)	3.94564592
36	positive regulation of icosanoid secretion (GO:0032305)	3.90473954
37	translation (GO:0006412)	3.87322472
38	regulation of prostaglandin secretion (GO:0032306)	3.85150765
39	signal complex assembly (GO:0007172)	3.78036530
40	GDP-mannose metabolic process (GO:0019673)	3.77166811
41	macromolecular complex disassembly (GO:0032984)	3.75966170
42	positive regulation of defense response to virus by host (GO:0002230)	3.67226690
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.61411658
44	regulation of immunoglobulin secretion (GO:0051023)	3.61395536
45	protein complex biogenesis (GO:0070271)	3.60787510
46	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.59919092
47	maturation of SSU-rRNA (GO:0030490)	3.55430146
48	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.48906536
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.45774206
50	termination of RNA polymerase I transcription (GO:0006363)	3.44449934
51	induction of positive chemotaxis (GO:0050930)	3.43100632
52	RNA localization (GO:0006403)	3.42721926
53	regulation of activation of Janus kinase activity (GO:0010533)	3.42692040
54	positive regulation of vascular permeability (GO:0043117)	3.40768432
55	regulation of glucocorticoid secretion (GO:2000849)	3.38925869
56	mRNA catabolic process (GO:0006402)	3.38180246
57	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34339422
58	nucleoside transport (GO:0015858)	3.29256930
59	mitochondrion morphogenesis (GO:0070584)	3.24490182
60	regulation of icosanoid secretion (GO:0032303)	3.22633704
61	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.22051801
62	cellular component biogenesis (GO:0044085)	3.21141006
63	transcription from RNA polymerase I promoter (GO:0006360)	3.19015671
64	piRNA metabolic process (GO:0034587)	3.12975825
65	regulation of isotype switching to IgG isotypes (GO:0048302)	3.11056371
66	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.06088700
67	intracellular protein transmembrane import (GO:0044743)	3.05129177
68	rRNA transcription (GO:0009303)	3.04394843
69	interferon-gamma production (GO:0032609)	3.03257367
70	rRNA metabolic process (GO:0016072)	3.03194459
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.00126606
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99798173
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99798173
74	NADH dehydrogenase complex assembly (GO:0010257)	2.99798173
75	ribosomal large subunit biogenesis (GO:0042273)	2.99109012
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98598201
77	negative regulation of mast cell activation (GO:0033004)	2.97524149
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97480385
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96725849
80	RNA catabolic process (GO:0006401)	2.95882353
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.95499976
82	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.95422429
83	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	2.92703846
84	electron transport chain (GO:0022900)	2.89136968
85	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	2.88967158
86	glycoprotein catabolic process (GO:0006516)	2.85133188
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84817159
88	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.84599978
89	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.84599978
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.83703831
91	termination of RNA polymerase III transcription (GO:0006386)	2.83703831
92	cytochrome complex assembly (GO:0017004)	2.83386717
93	respiratory electron transport chain (GO:0022904)	2.80224023
94	ATP biosynthetic process (GO:0006754)	2.78969198
95	meiotic chromosome segregation (GO:0045132)	2.78579738
96	rRNA modification (GO:0000154)	2.74639886
97	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.74452709
98	ribonucleoprotein complex biogenesis (GO:0022613)	2.74337639
99	response to pheromone (GO:0019236)	2.73416917
100	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72903194

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.44941701
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.99637813
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.13273747
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10510915
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.08049049
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.77519514
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.73254681
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.48788757
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42071599
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33264450
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.30803366
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25848492
13	VDR_22108803_ChIP-Seq_LS180_Human	2.25349407
14	STAT1_20625510_ChIP-Seq_HELA_Human	2.14026568
15	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.11786763
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.01016532
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00626289
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97429880
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91481325
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89096646
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.88154303
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85313212
23	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.84777804
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.78545663
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.75405735
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.64859165
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63643875
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.57185204
29	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.56934052
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.56613711
31	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.56347839
32	RBPJ_21746931_ChIP-Seq_IB4_Human	1.56273111
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.53653525
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51257576
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51257576
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47543675
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.47223104
38	PHF8_20622853_ChIP-Seq_HELA_Human	1.46964562
39	ETV1_20927104_ChIP-Seq_GIST48_Human	1.46511414
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.45259002
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43941724
42	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.43606364
43	RUNX_20019798_ChIP-Seq_JUKART_Human	1.42205953
44	AR_20517297_ChIP-Seq_VCAP_Human	1.41199989
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40534856
46	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.40129478
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.36365254
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33672617
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33378509
50	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31695405
51	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.31435263
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30798021
53	NCOR_22424771_ChIP-Seq_293T_Human	1.29523066
54	GATA3_26560356_Chip-Seq_TH2_Human	1.29049923
55	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.26295521
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26204264
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24965508
58	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24128899
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23932477
60	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.23036543
61	FUS_26573619_Chip-Seq_HEK293_Human	1.21924732
62	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.20599847
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20142328
64	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.17594360
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15105961
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15105961
67	TAF15_26573619_Chip-Seq_HEK293_Human	1.14969507
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13463597
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.11393042
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10407683
71	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09510408
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07740274
73	P300_19829295_ChIP-Seq_ESCs_Human	1.07625344
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06743583
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.05968004
76	NFYA_21822215_ChIP-Seq_K562_Human	1.05620862
77	XRN2_22483619_ChIP-Seq_HELA_Human	1.05401796
78	TP53_16413492_ChIP-PET_HCT116_Human	1.04608591
79	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04248390
80	EWS_26573619_Chip-Seq_HEK293_Human	1.04089857
81	E2F1_20622854_ChIP-Seq_HELA_Human	1.01974074
82	GBX2_23144817_ChIP-Seq_PC3_Human	1.01291654
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01115092
84	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.00244844
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99922484
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99901401
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99018759
88	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98623041
89	EGR1_19032775_ChIP-ChIP_M12_Human	0.98193219
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97318596
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.96922214
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96693676
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.93445067
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93238756
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.93007561
96	ERA_21632823_ChIP-Seq_H3396_Human	0.92696105
97	SOX2_21211035_ChIP-Seq_LN229_Human	0.91985076
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90997635
99	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.89722308
100	NFYB_21822215_ChIP-Seq_K562_Human	0.89031377

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.17310821
2	MP0005623_abnormal_meninges_morphology	5.10538170
3	MP0002638_abnormal_pupillary_reflex	4.28775261
4	MP0002102_abnormal_ear_morphology	4.09154383
5	MP0003646_muscle_fatigue	3.91748767
6	MP0005671_abnormal_response_to	3.27033472
7	MP0002938_white_spotting	3.08576590
8	MP0009384_cardiac_valve_regurgitation	2.48924841
9	MP0001968_abnormal_touch/_nociception	2.21071397
10	MP0000750_abnormal_muscle_regeneration	2.11244573
11	MP0009333_abnormal_splenocyte_physiolog	2.08752327
12	MP0002277_abnormal_respiratory_mucosa	2.07366603
13	MP0006292_abnormal_olfactory_placode	2.07121911
14	MP0005387_immune_system_phenotype	2.05922979
15	MP0001790_abnormal_immune_system	2.05922979
16	MP0001835_abnormal_antigen_presentation	2.04149137
17	MP0006072_abnormal_retinal_apoptosis	1.81172917
18	MP0000013_abnormal_adipose_tissue	1.74337357
19	MP0002148_abnormal_hypersensitivity_rea	1.61477581
20	MP0004145_abnormal_muscle_electrophysio	1.60942188
21	MP0008872_abnormal_physiological_respon	1.60289526
22	MP0003786_premature_aging	1.58153133
23	MP0008875_abnormal_xenobiotic_pharmacok	1.53696375
24	MP0003136_yellow_coat_color	1.52896866
25	MP0001800_abnormal_humoral_immune	1.41914240
26	MP0001905_abnormal_dopamine_level	1.41825228
27	MP0005410_abnormal_fertilization	1.37144052
28	MP0000343_altered_response_to	1.35863490
29	MP0001873_stomach_inflammation	1.35642338
30	MP0005551_abnormal_eye_electrophysiolog	1.35237437
31	MP0002163_abnormal_gland_morphology	1.34772984
32	MP0004147_increased_porphyrin_level	1.31606122
33	MP0003195_calcinosis	1.31288372
34	MP0005083_abnormal_biliary_tract	1.29955730
35	MP0003879_abnormal_hair_cell	1.29490141
36	MP0006082_CNS_inflammation	1.25251050
37	MP0010307_abnormal_tumor_latency	1.25159229
38	MP0005174_abnormal_tail_pigmentation	1.25003603
39	MP0001986_abnormal_taste_sensitivity	1.23532090
40	MP0002095_abnormal_skin_pigmentation	1.21569580
41	MP0003878_abnormal_ear_physiology	1.18530415
42	MP0005377_hearing/vestibular/ear_phenot	1.18530415
43	MP0009764_decreased_sensitivity_to	1.15746573
44	MP0002837_dystrophic_cardiac_calcinosis	1.14943470
45	MP0000858_altered_metastatic_potential	1.14063443
46	MP0005645_abnormal_hypothalamus_physiol	1.13100863
47	MP0002723_abnormal_immune_serum	1.09085023
48	MP0009785_altered_susceptibility_to	1.08714941
49	MP0002933_joint_inflammation	1.08654971
50	MP0005503_abnormal_tendon_morphology	1.08112073
51	MP0004885_abnormal_endolymph	1.07977561
52	MP0000762_abnormal_tongue_morphology	1.06848099
53	MP0010386_abnormal_urinary_bladder	1.02922416
54	MP0002876_abnormal_thyroid_physiology	0.99880557
55	MP0004142_abnormal_muscle_tone	0.99341392
56	MP0008775_abnormal_heart_ventricle	0.97794694
57	MP0009745_abnormal_behavioral_response	0.97147731
58	MP0005000_abnormal_immune_tolerance	0.95676674
59	MP0005389_reproductive_system_phenotype	0.94962639
60	MP0001485_abnormal_pinna_reflex	0.94584525
61	MP0005332_abnormal_amino_acid	0.92978822
62	MP0002736_abnormal_nociception_after	0.90786944
63	MP0002160_abnormal_reproductive_system	0.90010682
64	MP0000372_irregular_coat_pigmentation	0.89359674
65	MP0001881_abnormal_mammary_gland	0.86331894
66	MP0000015_abnormal_ear_pigmentation	0.86076184
67	MP0002177_abnormal_outer_ear	0.84479239
68	MP0003186_abnormal_redox_activity	0.83489827
69	MP0003436_decreased_susceptibility_to	0.82893514
70	MP0003718_maternal_effect	0.81865949
71	MP0002420_abnormal_adaptive_immunity	0.80619177
72	MP0001819_abnormal_immune_cell	0.80574487
73	MP0004484_altered_response_of	0.80334082
74	MP0009250_abnormal_appendicular_skeleto	0.79113291
75	MP0002067_abnormal_sensory_capabilities	0.78731133
76	MP0002452_abnormal_antigen_presenting	0.76988513
77	MP0003638_abnormal_response/metabolism_	0.75434662
78	MP0002138_abnormal_hepatobiliary_system	0.73512517
79	MP0008873_increased_physiological_sensi	0.71834994
80	MP0004742_abnormal_vestibular_system	0.70372621
81	MP0001853_heart_inflammation	0.69966621
82	MP0005025_abnormal_response_to	0.68274369
83	MP0001502_abnormal_circadian_rhythm	0.67816608
84	MP0005253_abnormal_eye_physiology	0.66813675
85	MP0005085_abnormal_gallbladder_physiolo	0.66502762
86	MP0004133_heterotaxia	0.66050967
87	MP0003137_abnormal_impulse_conducting	0.65704350
88	MP0005084_abnormal_gallbladder_morpholo	0.65104756
89	MP0005379_endocrine/exocrine_gland_phen	0.64989950
90	MP0002909_abnormal_adrenal_gland	0.64839250
91	MP0004381_abnormal_hair_follicle	0.64594981
92	MP0005636_abnormal_mineral_homeostasis	0.64181531
93	MP0004215_abnormal_myocardial_fiber	0.63564290
94	MP0003011_delayed_dark_adaptation	0.62813338
95	MP0004130_abnormal_muscle_cell	0.62662695
96	MP0001348_abnormal_lacrimal_gland	0.62310550
97	MP0000685_abnormal_immune_system	0.61812138
98	MP0002106_abnormal_muscle_physiology	0.61537549
99	MP0010155_abnormal_intestine_physiology	0.61466682
100	MP0001845_abnormal_inflammatory_respons	0.60745493

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal atrophy (HP:0001105)	6.94071142
2	Type II lissencephaly (HP:0007260)	6.87817625
3	Cerebellar dysplasia (HP:0007033)	6.58846088
4	Hypoplasia of the pons (HP:0012110)	6.22295765
5	Abnormality of the pons (HP:0007361)	5.76318853
6	Retinal dysplasia (HP:0007973)	5.49238063
7	Buphthalmos (HP:0000557)	4.77331450
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.58418375
9	Aplasia/Hypoplasia affecting the retina (HP:0008061)	4.51623181
10	Fatigue (HP:0012378)	4.21607038
11	Abolished electroretinogram (ERG) (HP:0000550)	4.01536229
12	Severe muscular hypotonia (HP:0006829)	3.92227182
13	Pallor (HP:0000980)	3.56524420
14	Increased IgM level (HP:0003496)	3.44038477
15	Congenital glaucoma (HP:0001087)	3.30682666
16	Hypoglycemic seizures (HP:0002173)	3.23301736
17	IgG deficiency (HP:0004315)	3.08623208
18	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.91257732
19	Congenital, generalized hypertrichosis (HP:0004540)	2.86361851
20	Acute necrotizing encephalopathy (HP:0006965)	2.75942879
21	3-Methylglutaconic aciduria (HP:0003535)	2.71415242
22	Elevated erythrocyte sedimentation rate (HP:0003565)	2.65072478
23	Difficulty climbing stairs (HP:0003551)	2.64342752
24	Congenital stationary night blindness (HP:0007642)	2.63851720
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.60055507
26	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.59934133
27	Generalized muscle weakness (HP:0003324)	2.57138717
28	Macrocytic anemia (HP:0001972)	2.50695787
29	Polydipsia (HP:0001959)	2.48078179
30	Abnormal drinking behavior (HP:0030082)	2.48078179
31	Acanthocytosis (HP:0001927)	2.40405117
32	Lipid accumulation in hepatocytes (HP:0006561)	2.39509191
33	Acute encephalopathy (HP:0006846)	2.38022669
34	Abnormality of midbrain morphology (HP:0002418)	2.36519715
35	Molar tooth sign on MRI (HP:0002419)	2.36519715
36	Global brain atrophy (HP:0002283)	2.35945165
37	Nephronophthisis (HP:0000090)	2.34382172
38	Increased CSF lactate (HP:0002490)	2.33901457
39	Mitochondrial inheritance (HP:0001427)	2.33552637
40	Progressive macrocephaly (HP:0004481)	2.31941410
41	Increased hepatocellular lipid droplets (HP:0006565)	2.30043639
42	Meningocele (HP:0002435)	2.29631121
43	Lissencephaly (HP:0001339)	2.29119548
44	Symptomatic seizures (HP:0011145)	2.27646238
45	Hypobetalipoproteinemia (HP:0003563)	2.27086979
46	Cerebral hypomyelination (HP:0006808)	2.25637767
47	Methylmalonic acidemia (HP:0002912)	2.25482060
48	Generalized hypotonia (HP:0001290)	2.23661089
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21150660
50	Congenital sensorineural hearing impairment (HP:0008527)	2.19912699
51	Decreased muscle mass (HP:0003199)	2.19060190
52	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.16956491
53	Abnormal number of erythroid precursors (HP:0012131)	2.16008920
54	Pancreatic cysts (HP:0001737)	2.15135012
55	Abnormality of the renal cortex (HP:0011035)	2.12671765
56	Entropion (HP:0000621)	2.09430357
57	Hyperglycinemia (HP:0002154)	2.05461050
58	Decreased circulating renin level (HP:0003351)	2.05394507
59	Megalocornea (HP:0000485)	2.00416013
60	Concave nail (HP:0001598)	1.97019443
61	Asplenia (HP:0001746)	1.96256167
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96107762
63	Diminished movement (HP:0002374)	1.93322559
64	Testicular atrophy (HP:0000029)	1.92991849
65	Abnormality of the renal medulla (HP:0100957)	1.92944503
66	Polyuria (HP:0000103)	1.92012933
67	Patent foramen ovale (HP:0001655)	1.91806065
68	Abnormality of DNA repair (HP:0003254)	1.91521944
69	Abnormality of the vitreous humor (HP:0004327)	1.90683552
70	Mesangial abnormality (HP:0001966)	1.88952478
71	Congenital ichthyosiform erythroderma (HP:0007431)	1.87990945
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87738285
73	Stomatitis (HP:0010280)	1.87188858
74	Renal Fanconi syndrome (HP:0001994)	1.86217398
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.84812992
76	Hypoalbuminemia (HP:0003073)	1.82469859
77	Abnormal albumin level (HP:0012116)	1.82469859
78	Stenosis of the external auditory canal (HP:0000402)	1.81680013
79	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.81107969
80	Fragile nails (HP:0001808)	1.80096360
81	Renal tubular dysfunction (HP:0000124)	1.80030315
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79765873
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79765873
84	Tubular atrophy (HP:0000092)	1.78461323
85	Non-midline cleft lip (HP:0100335)	1.76870773
86	Eosinophilia (HP:0001880)	1.76677060
87	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.75949610
88	Hypoplasia of the brainstem (HP:0002365)	1.75949610
89	Colon cancer (HP:0003003)	1.74117052
90	Dyskinesia (HP:0100660)	1.74075437
91	Oral leukoplakia (HP:0002745)	1.73968727
92	Methylmalonic aciduria (HP:0012120)	1.72814890
93	Dysphonia (HP:0001618)	1.69998827
94	Cellular immunodeficiency (HP:0005374)	1.65632743
95	Premature ovarian failure (HP:0008209)	1.65626038
96	Aplastic anemia (HP:0001915)	1.65327355
97	Reticulocytopenia (HP:0001896)	1.64131644
98	Abnormality of vision evoked potentials (HP:0000649)	1.63333735
99	Poikiloderma (HP:0001029)	1.62242151
100	Abnormal biliary tract physiology (HP:0012439)	1.61682541

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	4.37845973
2	STK10	4.28114254
3	RIPK1	4.11932567
4	TXK	3.99962851
5	MAP4K1	3.38878827
6	TLK1	3.26551272
7	ADRBK2	3.22685642
8	PDK2	2.30481096
9	MUSK	2.23469587
10	STK39	2.17508209
11	WNK4	2.15262727
12	NEK1	1.90333363
13	GRK1	1.87833606
14	PIM1	1.84599704
15	PTK2B	1.76422590
16	PASK	1.75647395
17	PRKCI	1.73391442
18	CLK1	1.67542204
19	ZAK	1.65794460
20	BMPR2	1.58165307
21	MAP2K6	1.53125318
22	FRK	1.49115749
23	WNK3	1.44363795
24	PRKD2	1.41638128
25	SRPK1	1.39818272
26	BMPR1B	1.27870018
27	OXSR1	1.22267927
28	PAK3	1.17277840
29	STK11	1.14429526
30	MST4	1.13659542
31	CDK8	1.08217630
32	GRK7	1.06161381
33	PRKCH	1.04572327
34	ADRBK1	1.04337880
35	PRKCG	1.04201469
36	TNIK	0.97401463
37	IKBKB	0.94176607
38	TSSK6	0.94166481
39	TEC	0.92691103
40	ABL2	0.92601581
41	VRK2	0.92042109
42	INSRR	0.86611786
43	LCK	0.86135863
44	PDPK1	0.86050834
45	FGFR1	0.85900665
46	DAPK3	0.85262770
47	PRKCE	0.82743009
48	NME1	0.82526047
49	TIE1	0.74097675
50	CAMKK2	0.69856280
51	RPS6KA5	0.68432370
52	PKN1	0.67489086
53	PRKCD	0.67306936
54	PBK	0.66693785
55	OBSCN	0.65731706
56	STK16	0.65265351
57	NLK	0.64902788
58	ERBB2	0.64078785
59	TGFBR1	0.62344087
60	MAP4K2	0.60232804
61	PRKCQ	0.60171085
62	ZAP70	0.59774998
63	CSNK2A2	0.57399486
64	LMTK2	0.53657323
65	VRK1	0.53460947
66	STK4	0.53294910
67	DYRK2	0.51817653
68	LIMK1	0.50300527
69	LYN	0.50128767
70	KDR	0.47126457
71	PHKG1	0.45330074
72	PHKG2	0.45330074
73	CSNK2A1	0.44912041
74	NME2	0.42522370
75	TGFBR2	0.41307316
76	MAPKAPK3	0.39245748
77	CAMK2A	0.38616956
78	TRIM28	0.37993367
79	FYN	0.37729821
80	BUB1	0.37463431
81	PLK3	0.37147685
82	CSK	0.37059520
83	AKT2	0.34872713
84	FGFR2	0.33990962
85	PRKACA	0.33919239
86	SYK	0.33624862
87	EIF2AK3	0.33012960
88	IGF1R	0.32866619
89	STK38L	0.32731642
90	PINK1	0.32492791
91	ITK	0.32127542
92	PRKCA	0.32054575
93	EPHB2	0.31417084
94	PIK3CA	0.30087104
95	WNK1	0.30052297
96	ERN1	0.28037204
97	MAPK13	0.27469810
98	PLK4	0.27347638
99	PRKCZ	0.26389300
100	MATK	0.26019242

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.92541986
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08893229
3	Sulfur relay system_Homo sapiens_hsa04122	2.96813948
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.77145460
5	Proteasome_Homo sapiens_hsa03050	2.69267944
6	Allograft rejection_Homo sapiens_hsa05330	2.50039819
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.44160322
8	Parkinsons disease_Homo sapiens_hsa05012	2.40097490
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.32371467
10	RNA polymerase_Homo sapiens_hsa03020	2.17703502
11	Asthma_Homo sapiens_hsa05310	2.06921280
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94718232
13	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.92865581
14	RNA degradation_Homo sapiens_hsa03018	1.88652689
15	Regulation of autophagy_Homo sapiens_hsa04140	1.85491229
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.80049786
17	Protein export_Homo sapiens_hsa03060	1.79524254
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77037439
19	Huntingtons disease_Homo sapiens_hsa05016	1.71251685
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.68803457
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67466004
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.67178906
23	Sulfur metabolism_Homo sapiens_hsa00920	1.66526028
24	Alzheimers disease_Homo sapiens_hsa05010	1.63775052
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62973572
26	Basal transcription factors_Homo sapiens_hsa03022	1.53282933
27	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.48059465
28	Caffeine metabolism_Homo sapiens_hsa00232	1.47932743
29	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.43401400
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42683651
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33282787
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.31264861
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.25597714
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.23820409
35	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.23646088
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21509015
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.20885252
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20812140
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.16676356
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.11510627
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07129132
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04272572
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.03720164
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.97285699
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.94932754
46	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.91717235
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.83752879
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.82812462
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82121791
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81139908
51	Mineral absorption_Homo sapiens_hsa04978	0.81131200
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.77980854
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77658745
54	Phototransduction_Homo sapiens_hsa04744	0.77073677
55	Mismatch repair_Homo sapiens_hsa03430	0.75207360
56	Olfactory transduction_Homo sapiens_hsa04740	0.74951257
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73619067
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.70151492
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69860991
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69346398
61	TNF signaling pathway_Homo sapiens_hsa04668	0.67110315
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66974925
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66472343
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65559050
65	Retinol metabolism_Homo sapiens_hsa00830	0.60989199
66	Nicotine addiction_Homo sapiens_hsa05033	0.57696319
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.56303523
68	RNA transport_Homo sapiens_hsa03013	0.55230972
69	Purine metabolism_Homo sapiens_hsa00230	0.53940423
70	Peroxisome_Homo sapiens_hsa04146	0.53641550
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.52233321
72	Metabolic pathways_Homo sapiens_hsa01100	0.47074602
73	Leishmaniasis_Homo sapiens_hsa05140	0.44652872
74	Homologous recombination_Homo sapiens_hsa03440	0.44297622
75	Glutathione metabolism_Homo sapiens_hsa00480	0.43597518
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43210061
77	One carbon pool by folate_Homo sapiens_hsa00670	0.41832344
78	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41735542
79	Spliceosome_Homo sapiens_hsa03040	0.41227309
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41075771
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41036906
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40075115
83	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38660070
84	Malaria_Homo sapiens_hsa05144	0.36844095
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35426784
86	Pancreatic secretion_Homo sapiens_hsa04972	0.32963210
87	Taste transduction_Homo sapiens_hsa04742	0.32666947
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28850048
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.26416901
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.25521397
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.21560646
92	Measles_Homo sapiens_hsa05162	0.20941664
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19413699
94	Propanoate metabolism_Homo sapiens_hsa00640	0.19156288
95	Insulin secretion_Homo sapiens_hsa04911	0.17025506
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.16868963
97	Fanconi anemia pathway_Homo sapiens_hsa03460	0.16641206
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.14310859
99	Folate biosynthesis_Homo sapiens_hsa00790	0.14302610
100	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.13739227

RPL23AP77

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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