ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.54442602
2	cytidine deamination (GO:0009972)	6.44544248
3	cytidine metabolic process (GO:0046087)	6.44544248
4	cytidine catabolic process (GO:0006216)	6.44544248
5	DNA deamination (GO:0045006)	6.18804356
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.90195837
7	ribosomal small subunit assembly (GO:0000028)	5.24493821
8	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.07342738
9	base-excision repair, AP site formation (GO:0006285)	4.74902188
10	immunoglobulin mediated immune response (GO:0016064)	4.70254720
11	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.67789066
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.64121871
13	response to pheromone (GO:0019236)	4.41318360
14	chaperone-mediated protein transport (GO:0072321)	4.40026998
15	T cell migration (GO:0072678)	4.34945913
16	viral transcription (GO:0019083)	4.29454508
17	actin nucleation (GO:0045010)	4.26716684
18	pyrimidine nucleotide catabolic process (GO:0006244)	4.23781678
19	translational termination (GO:0006415)	4.14216053
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.13448498
21	regulation of regulatory T cell differentiation (GO:0045589)	4.07651893
22	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.06564428
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.00461290
24	ATP synthesis coupled proton transport (GO:0015986)	4.00461290
25	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.00070429
26	negative T cell selection (GO:0043383)	3.82589561
27	positive T cell selection (GO:0043368)	3.80310657
28	regulation of T cell tolerance induction (GO:0002664)	3.79336867
29	GPI anchor biosynthetic process (GO:0006506)	3.77602329
30	B cell mediated immunity (GO:0019724)	3.68778181
31	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.67563513
32	translational elongation (GO:0006414)	3.63506047
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.61966049
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.60186722
35	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.58848331
36	GPI anchor metabolic process (GO:0006505)	3.57862424
37	positive thymic T cell selection (GO:0045059)	3.54397664
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.52845356
39	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.52277132
40	cotranslational protein targeting to membrane (GO:0006613)	3.51405002
41	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.50383028
42	pyrimidine nucleoside catabolic process (GO:0046135)	3.50312898
43	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.49539651
44	protein targeting to ER (GO:0045047)	3.47893543
45	negative regulation by host of viral transcription (GO:0043922)	3.45041800
46	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.43276576
47	mitochondrial calcium ion transport (GO:0006851)	3.42965929
48	positive regulation of defense response to virus by host (GO:0002230)	3.37547552
49	behavioral response to nicotine (GO:0035095)	3.37020829
50	male meiosis I (GO:0007141)	3.34670161
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.32273061
52	protein localization to endoplasmic reticulum (GO:0070972)	3.29773683
53	positive regulation of tolerance induction (GO:0002645)	3.28023280
54	viral life cycle (GO:0019058)	3.25504366
55	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.20661227
56	cellular response to interleukin-15 (GO:0071350)	3.19195189
57	protein complex biogenesis (GO:0070271)	3.18801793
58	positive regulation of interleukin-4 production (GO:0032753)	3.16515351
59	regulation of isotype switching to IgG isotypes (GO:0048302)	3.15479978
60	positive regulation of gamma-delta T cell activation (GO:0046645)	3.12747512
61	lymphocyte chemotaxis (GO:0048247)	3.09669914
62	cytolysis (GO:0019835)	3.09442790
63	cellular protein complex disassembly (GO:0043624)	3.08389352
64	ribosomal small subunit biogenesis (GO:0042274)	3.07152821
65	T cell receptor signaling pathway (GO:0050852)	3.06432904
66	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.06389766
67	regulation of natural killer cell mediated immunity (GO:0002715)	3.06389766
68	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.04407191
69	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.03313189
70	electron transport chain (GO:0022900)	3.02864374
71	pyrimidine-containing compound catabolic process (GO:0072529)	3.02239057
72	positive regulation of cell killing (GO:0031343)	3.01669606
73	inner mitochondrial membrane organization (GO:0007007)	3.00602387
74	thymic T cell selection (GO:0045061)	2.99374601
75	maturation of SSU-rRNA (GO:0030490)	2.97430060
76	respiratory electron transport chain (GO:0022904)	2.96517692
77	regulation of memory T cell differentiation (GO:0043380)	2.96214353
78	positive regulation of calcium-mediated signaling (GO:0050850)	2.95953961
79	regulation of tolerance induction (GO:0002643)	2.95803411
80	deoxyribonucleotide catabolic process (GO:0009264)	2.93605742
81	negative thymic T cell selection (GO:0045060)	2.91818896
82	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.89502579
83	sequestering of actin monomers (GO:0042989)	2.88916721
84	negative regulation of T cell apoptotic process (GO:0070233)	2.88845697
85	negative regulation of telomere maintenance (GO:0032205)	2.88557115
86	leukocyte aggregation (GO:0070486)	2.88106605
87	regulation of alpha-beta T cell proliferation (GO:0046640)	2.87468043
88	positive regulation of interleukin-17 production (GO:0032740)	2.84997575
89	deoxyribose phosphate catabolic process (GO:0046386)	2.82633736
90	lymphocyte migration (GO:0072676)	2.81475516
91	T cell costimulation (GO:0031295)	2.81402990
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.80743890
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.80743890
94	lymphocyte costimulation (GO:0031294)	2.79334522
95	translation (GO:0006412)	2.77904413
96	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.77026368
97	positive regulation of B cell mediated immunity (GO:0002714)	2.76485905
98	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.76485905
99	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76421275
100	translational initiation (GO:0006413)	2.76238697

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.57791761
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.54619597
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54290032
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.40157641
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.29606110
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.24048015
7	VDR_22108803_ChIP-Seq_LS180_Human	3.10638798
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.86404210
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.57831439
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53493756
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53437666
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.45431092
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12793610
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.02320046
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00715257
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.98695855
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91396737
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80762275
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.78991900
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72804908
21	MYB_26560356_Chip-Seq_TH2_Human	1.68490205
22	GATA3_26560356_Chip-Seq_TH2_Human	1.66589678
23	GATA3_27048872_Chip-Seq_THYMUS_Human	1.64663084
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.62917864
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.57736473
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57088203
27	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.53918748
28	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.53740285
29	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.53427748
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50427547
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.48664922
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.47440418
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.46988655
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46937264
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.45618228
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.42741861
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42448113
38	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.42298169
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.40948481
40	RAC3_21632823_ChIP-Seq_H3396_Human	1.39290813
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.37637164
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37067029
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.35870735
44	P300_27268052_Chip-Seq_Bcells_Human	1.35734009
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33327835
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33303433
47	E2F1_20622854_ChIP-Seq_HELA_Human	1.29760639
48	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28901385
49	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27211201
50	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.26316593
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25426375
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23209757
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22047907
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21951486
55	AR_20517297_ChIP-Seq_VCAP_Human	1.21376402
56	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20461597
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19272668
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19142597
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18987556
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18644778
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18644778
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.17561661
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.16939109
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16665888
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16023185
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.16005944
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15103072
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15103072
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14848547
70	CTCF_20526341_ChIP-Seq_ESCs_Human	1.13610737
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.13523354
72	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13422133
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11877249
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11793611
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09404879
76	STAT1_20625510_ChIP-Seq_HELA_Human	1.09320127
77	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08630981
78	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08346004
79	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07556187
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06917104
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04729714
82	OCT4_20526341_ChIP-Seq_ESCs_Human	1.04720204
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04261452
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02949473
85	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.02716678
86	BCOR_27268052_Chip-Seq_Bcells_Human	1.02652094
87	ERG_20517297_ChIP-Seq_VCAP_Human	1.01527497
88	ERA_21632823_ChIP-Seq_H3396_Human	0.99447800
89	NCOR_22424771_ChIP-Seq_293T_Human	0.98857208
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98538459
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98234088
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97940648
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96848635
94	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.96632880
95	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95733100
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95248051
97	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95082555
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.94908896
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94690331
100	MYB_26560356_Chip-Seq_TH1_Human	0.92967506

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.93659383
2	MP0001835_abnormal_antigen_presentation	3.53516479
3	MP0009379_abnormal_foot_pigmentation	3.48271730
4	MP0003646_muscle_fatigue	3.35145354
5	MP0002163_abnormal_gland_morphology	2.85269677
6	MP0005387_immune_system_phenotype	2.67258596
7	MP0001790_abnormal_immune_system	2.67258596
8	MP0009333_abnormal_splenocyte_physiolog	2.59922221
9	MP0003011_delayed_dark_adaptation	2.59396041
10	MP0002102_abnormal_ear_morphology	2.51574822
11	MP0009785_altered_susceptibility_to	2.49150338
12	MP0003763_abnormal_thymus_physiology	2.44124349
13	MP0006072_abnormal_retinal_apoptosis	2.26415573
14	MP0002166_altered_tumor_susceptibility	2.13213138
15	MP0001800_abnormal_humoral_immune	2.07087626
16	MP0002148_abnormal_hypersensitivity_rea	1.94688355
17	MP0003786_premature_aging	1.93861084
18	MP0001986_abnormal_taste_sensitivity	1.92459547
19	MP0005000_abnormal_immune_tolerance	1.92340709
20	MP0002723_abnormal_immune_serum	1.92330421
21	MP0002420_abnormal_adaptive_immunity	1.82201747
22	MP0005025_abnormal_response_to	1.77377199
23	MP0001819_abnormal_immune_cell	1.74539358
24	MP0006292_abnormal_olfactory_placode	1.73156372
25	MP0005253_abnormal_eye_physiology	1.71589875
26	MP0002638_abnormal_pupillary_reflex	1.63906963
27	MP0008995_early_reproductive_senescence	1.63815509
28	MP0005377_hearing/vestibular/ear_phenot	1.57742966
29	MP0003878_abnormal_ear_physiology	1.57742966
30	MP0005551_abnormal_eye_electrophysiolog	1.57095996
31	MP0003195_calcinosis	1.53510695
32	MP0002006_tumorigenesis	1.53367405
33	MP0002277_abnormal_respiratory_mucosa	1.51463995
34	MP0004145_abnormal_muscle_electrophysio	1.50514660
35	MP0005379_endocrine/exocrine_gland_phen	1.49597199
36	MP0005670_abnormal_white_adipose	1.49456320
37	MP0002095_abnormal_skin_pigmentation	1.45898174
38	MP0003866_abnormal_defecation	1.44636646
39	MP0008789_abnormal_olfactory_epithelium	1.42914367
40	MP0002452_abnormal_antigen_presenting	1.40407507
41	MP0002876_abnormal_thyroid_physiology	1.39116394
42	MP0000372_irregular_coat_pigmentation	1.33420040
43	MP0004043_abnormal_pH_regulation	1.32391872
44	MP0009764_decreased_sensitivity_to	1.28183872
45	MP0008872_abnormal_physiological_respon	1.26332072
46	MP0001919_abnormal_reproductive_system	1.25097252
47	MP0002736_abnormal_nociception_after	1.24850103
48	MP0001905_abnormal_dopamine_level	1.24085663
49	MP0000685_abnormal_immune_system	1.23412228
50	MP0002909_abnormal_adrenal_gland	1.18513734
51	MP0001968_abnormal_touch/_nociception	1.17443904
52	MP0000716_abnormal_immune_system	1.16071077
53	MP0005389_reproductive_system_phenotype	1.15666468
54	MP0001845_abnormal_inflammatory_respons	1.15230012
55	MP0002822_catalepsy	1.14755242
56	MP0002398_abnormal_bone_marrow	1.11062243
57	MP0004036_abnormal_muscle_relaxation	1.09170509
58	MP0000689_abnormal_spleen_morphology	1.04626373
59	MP0003567_abnormal_fetal_cardiomyocyte	1.00476798
60	MP0006036_abnormal_mitochondrial_physio	1.00375852
61	MP0010155_abnormal_intestine_physiology	0.98965060
62	MP0001485_abnormal_pinna_reflex	0.98212831
63	MP0009745_abnormal_behavioral_response	0.97890577
64	MP0006082_CNS_inflammation	0.94908199
65	MP0000639_abnormal_adrenal_gland	0.94823542
66	MP0005075_abnormal_melanosome_morpholog	0.93918829
67	MP0008877_abnormal_DNA_methylation	0.93850099
68	MP0002837_dystrophic_cardiac_calcinosis	0.93819049
69	MP0002138_abnormal_hepatobiliary_system	0.93673195
70	MP0000427_abnormal_hair_cycle	0.92770397
71	MP0002272_abnormal_nervous_system	0.90949951
72	MP0005085_abnormal_gallbladder_physiolo	0.90692513
73	MP0005645_abnormal_hypothalamus_physiol	0.89340897
74	MP0000703_abnormal_thymus_morphology	0.89187702
75	MP0002419_abnormal_innate_immunity	0.88808448
76	MP0000604_amyloidosis	0.86683914
77	MP0008469_abnormal_protein_level	0.86591778
78	MP0009046_muscle_twitch	0.86157429
79	MP0002933_joint_inflammation	0.85581976
80	MP0003045_fibrosis	0.84448920
81	MP0002429_abnormal_blood_cell	0.84358287
82	MP0002160_abnormal_reproductive_system	0.84318078
83	MP0005646_abnormal_pituitary_gland	0.82650277
84	MP0002722_abnormal_immune_system	0.81815289
85	MP0003950_abnormal_plasma_membrane	0.80311650
86	MP0004742_abnormal_vestibular_system	0.78436522
87	MP0010329_abnormal_lipoprotein_level	0.77948442
88	MP0004885_abnormal_endolymph	0.75673709
89	MP0004142_abnormal_muscle_tone	0.75493796
90	MP0004947_skin_inflammation	0.74407057
91	MP0005499_abnormal_olfactory_system	0.73659710
92	MP0005394_taste/olfaction_phenotype	0.73659710
93	MP0008875_abnormal_xenobiotic_pharmacok	0.73041411
94	MP0009763_increased_sensitivity_to	0.72497166
95	MP0005166_decreased_susceptibility_to	0.71814716
96	MP0003436_decreased_susceptibility_to	0.71587968
97	MP0004381_abnormal_hair_follicle	0.70985952
98	MP0000631_abnormal_neuroendocrine_gland	0.70016959
99	MP0003137_abnormal_impulse_conducting	0.69507713
100	MP0009765_abnormal_xenobiotic_induced	0.69179458

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgM level (HP:0003496)	4.75366607
2	IgG deficiency (HP:0004315)	4.71848155
3	Aplastic anemia (HP:0001915)	4.07132639
4	Congenital stationary night blindness (HP:0007642)	3.98758963
5	Recurrent bronchitis (HP:0002837)	3.89718559
6	T lymphocytopenia (HP:0005403)	3.88844951
7	Agammaglobulinemia (HP:0004432)	3.81012524
8	Abnormality of T cell number (HP:0011839)	3.52902709
9	Lipid accumulation in hepatocytes (HP:0006561)	3.29524523
10	Abnormality of T cells (HP:0002843)	3.23900010
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.22051929
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.22051929
13	Colon cancer (HP:0003003)	3.12549993
14	Hepatocellular necrosis (HP:0001404)	3.05380249
15	Chronic sinusitis (HP:0011109)	2.93910460
16	Stomatitis (HP:0010280)	2.93472224
17	Increased muscle lipid content (HP:0009058)	2.91937284
18	Severe combined immunodeficiency (HP:0004430)	2.91138533
19	Mitochondrial inheritance (HP:0001427)	2.90757213
20	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.84478780
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.78330486
22	Reticulocytopenia (HP:0001896)	2.58199500
23	Polydipsia (HP:0001959)	2.55804476
24	Abnormal drinking behavior (HP:0030082)	2.55804476
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55706667
26	Bronchitis (HP:0012387)	2.54843003
27	Acute necrotizing encephalopathy (HP:0006965)	2.52782464
28	Autoimmune hemolytic anemia (HP:0001890)	2.52298425
29	Increased CSF lactate (HP:0002490)	2.50920181
30	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.49947811
31	Hepatic necrosis (HP:0002605)	2.49117457
32	Methylmalonic acidemia (HP:0002912)	2.49030585
33	Hematochezia (HP:0002573)	2.46927959
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45721092
35	Hypoalbuminemia (HP:0003073)	2.45595505
36	Abnormal albumin level (HP:0012116)	2.45595505
37	Panhypogammaglobulinemia (HP:0003139)	2.42760786
38	Congenital, generalized hypertrichosis (HP:0004540)	2.41225297
39	Abolished electroretinogram (ERG) (HP:0000550)	2.38674704
40	Encephalitis (HP:0002383)	2.34047214
41	Methylmalonic aciduria (HP:0012120)	2.28743448
42	Renal Fanconi syndrome (HP:0001994)	2.26634599
43	Short tibia (HP:0005736)	2.20361496
44	Abnormality of cells of the erythroid lineage (HP:0012130)	2.18864784
45	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.18510182
46	Recurrent cutaneous fungal infections (HP:0011370)	2.16166577
47	Chronic mucocutaneous candidiasis (HP:0002728)	2.16166577
48	Abnormality of eosinophils (HP:0001879)	2.14633149
49	Meningitis (HP:0001287)	2.14284185
50	Abnormality of T cell physiology (HP:0011840)	2.14112915
51	Combined immunodeficiency (HP:0005387)	2.14111723
52	Facial diplegia (HP:0001349)	2.13080836
53	Acute encephalopathy (HP:0006846)	2.08940012
54	Medial flaring of the eyebrow (HP:0010747)	2.08700628
55	Abnormal number of erythroid precursors (HP:0012131)	2.08243514
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07604372
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07451464
58	Hypokalemia (HP:0002900)	2.05263393
59	Thyroiditis (HP:0100646)	2.04614248
60	Hyperlipoproteinemia (HP:0010980)	2.02518667
61	Abnormality of the renal cortex (HP:0011035)	2.01046534
62	Chronic diarrhea (HP:0002028)	2.00972513
63	Macrocytic anemia (HP:0001972)	2.00352021
64	Enlarged kidneys (HP:0000105)	1.99480658
65	IgM deficiency (HP:0002850)	1.97250180
66	Progressive macrocephaly (HP:0004481)	1.97192262
67	Renal cortical cysts (HP:0000803)	1.97081997
68	Abnormality of the prostate (HP:0008775)	1.96523374
69	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.96129170
70	Abnormality of the middle phalanges of the toes (HP:0010183)	1.95975515
71	Pallor (HP:0000980)	1.95569958
72	Hypoproteinemia (HP:0003075)	1.95007268
73	Nephrogenic diabetes insipidus (HP:0009806)	1.94454116
74	Increased intramyocellular lipid droplets (HP:0012240)	1.94179698
75	Recurrent otitis media (HP:0000403)	1.93361509
76	3-Methylglutaconic aciduria (HP:0003535)	1.92943771
77	Polyuria (HP:0000103)	1.92703558
78	Parakeratosis (HP:0001036)	1.90691817
79	IgA deficiency (HP:0002720)	1.89853886
80	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.89448995
81	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89270286
82	Dicarboxylic aciduria (HP:0003215)	1.89270286
83	Abnormal rod and cone electroretinograms (HP:0008323)	1.86880363
84	B lymphocytopenia (HP:0010976)	1.86880350
85	Hypergammaglobulinemia (HP:0010702)	1.86701810
86	Lymphopenia (HP:0001888)	1.85751555
87	Abnormality of B cell number (HP:0010975)	1.84686537
88	Prostate neoplasm (HP:0100787)	1.84580849
89	Decreased central vision (HP:0007663)	1.84364425
90	Pancreatic cysts (HP:0001737)	1.84035450
91	Hypoplasia of the ulna (HP:0003022)	1.83901977
92	Stenosis of the external auditory canal (HP:0000402)	1.81247115
93	Abnormality of midbrain morphology (HP:0002418)	1.80959391
94	Molar tooth sign on MRI (HP:0002419)	1.80959391
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80337467
96	Pancytopenia (HP:0001876)	1.78791368
97	Eosinophilia (HP:0001880)	1.77830338
98	Increased hepatocellular lipid droplets (HP:0006565)	1.76885852
99	Chorioretinal atrophy (HP:0000533)	1.76199669
100	Respiratory failure (HP:0002878)	1.75431447

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.60005935
2	KDR	3.98731899
3	MAP4K1	3.72141061
4	ADRBK2	3.36164584
5	TXK	3.08355716
6	ERN1	2.95181632
7	GRK1	2.69169836
8	FES	2.60185687
9	ITK	2.22736238
10	MAP2K2	2.22637136
11	WNK4	2.06490127
12	TEC	2.04375836
13	BCKDK	1.67446752
14	NEK1	1.61805845
15	IKBKE	1.57378915
16	NLK	1.56359083
17	MAP3K12	1.55586998
18	TLK1	1.52185213
19	SYK	1.49739358
20	PIK3CA	1.45465048
21	SIK3	1.43929204
22	CDK19	1.36716882
23	MAP3K11	1.24318739
24	IKBKB	1.23856377
25	CSK	1.23774768
26	MAPKAPK3	1.19926366
27	PRKCQ	1.18702949
28	MAPK13	1.18469634
29	BTK	1.11333966
30	BUB1	1.09438360
31	LCK	1.03412185
32	STK10	1.00142071
33	LYN	1.00028067
34	DAPK1	0.96862613
35	GRK6	0.95913849
36	MARK3	0.95405137
37	DAPK2	0.95047196
38	ILK	0.94788635
39	LIMK1	0.93958368
40	MAP4K2	0.93550327
41	ADRBK1	0.92851514
42	PASK	0.90772764
43	DYRK2	0.87294350
44	TBK1	0.85536563
45	INSRR	0.84428387
46	MUSK	0.84024953
47	MST4	0.78181290
48	ACVR1B	0.77257670
49	NEK6	0.76876148
50	ZAP70	0.76151237
51	STK39	0.75616152
52	TAOK3	0.74766774
53	STK16	0.74624188
54	TESK1	0.73739136
55	RPS6KA5	0.72121972
56	LRRK2	0.69674112
57	OBSCN	0.63293228
58	GRK7	0.62883098
59	PRKACA	0.60499120
60	TYRO3	0.58890591
61	FRK	0.57840175
62	CSNK1G3	0.56566257
63	CSF1R	0.55591249
64	SIK2	0.55318955
65	HCK	0.54590057
66	IRAK2	0.52855083
67	ZAK	0.52596633
68	CSNK1G2	0.50439232
69	MAP3K8	0.48898040
70	PRKCA	0.48255600
71	IGF1R	0.48150310
72	FYN	0.47342487
73	PLK4	0.47326009
74	PRKCE	0.47272602
75	MYLK	0.47069903
76	TIE1	0.46644652
77	PINK1	0.45925497
78	ERBB3	0.45135131
79	CSNK1A1L	0.44859812
80	JAK3	0.44766754
81	PLK2	0.44185396
82	CAMKK1	0.43343865
83	CSNK2A2	0.43309857
84	BLK	0.43127992
85	MAP2K6	0.40621999
86	CAMK1	0.40589444
87	BMPR1B	0.40455924
88	MAP2K1	0.39657811
89	CSNK1G1	0.38954571
90	PIM1	0.37750550
91	ABL2	0.37592713
92	STK11	0.37308612
93	DAPK3	0.36939366
94	CAMKK2	0.36502019
95	INSR	0.35693827
96	ABL1	0.33969001
97	MAP2K7	0.33636018
98	EIF2AK3	0.33193055
99	CSNK1A1	0.32758664
100	CSNK2A1	0.32359145

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.78263238
2	Allograft rejection_Homo sapiens_hsa05330	3.91462758
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.77468287
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.65848696
5	Asthma_Homo sapiens_hsa05310	3.62518111
6	Ribosome_Homo sapiens_hsa03010	3.38371046
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.04375753
8	Proteasome_Homo sapiens_hsa03050	2.82248227
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.80109085
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68861380
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63461903
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.62879659
13	Parkinsons disease_Homo sapiens_hsa05012	2.51618729
14	Viral myocarditis_Homo sapiens_hsa05416	1.99128781
15	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.84105960
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.81952331
17	Phototransduction_Homo sapiens_hsa04744	1.77706096
18	Alzheimers disease_Homo sapiens_hsa05010	1.62851706
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60797632
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55067276
21	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.50778354
22	Huntingtons disease_Homo sapiens_hsa05016	1.36832596
23	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.36478808
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.33775715
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.27463734
26	Protein export_Homo sapiens_hsa03060	1.26779373
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23639300
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.20856746
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19755657
30	Sulfur relay system_Homo sapiens_hsa04122	1.18545870
31	Olfactory transduction_Homo sapiens_hsa04740	1.11892289
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.08463779
33	Caffeine metabolism_Homo sapiens_hsa00232	1.06485399
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.05796847
35	RNA polymerase_Homo sapiens_hsa03020	1.05432349
36	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.02567483
37	Retinol metabolism_Homo sapiens_hsa00830	0.88252839
38	Selenocompound metabolism_Homo sapiens_hsa00450	0.82044902
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81496616
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80431573
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80143647
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.69388716
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69367719
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68425715
45	Peroxisome_Homo sapiens_hsa04146	0.64098722
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60383553
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59818919
48	Homologous recombination_Homo sapiens_hsa03440	0.59290329
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59281514
50	One carbon pool by folate_Homo sapiens_hsa00670	0.59191119
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56450566
52	Leishmaniasis_Homo sapiens_hsa05140	0.55824803
53	Malaria_Homo sapiens_hsa05144	0.53856208
54	Measles_Homo sapiens_hsa05162	0.53305682
55	Morphine addiction_Homo sapiens_hsa05032	0.52441730
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51495814
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50791642
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49526882
59	Shigellosis_Homo sapiens_hsa05131	0.49063500
60	Legionellosis_Homo sapiens_hsa05134	0.48345008
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.47046861
62	Salmonella infection_Homo sapiens_hsa05132	0.45810526
63	GABAergic synapse_Homo sapiens_hsa04727	0.45580230
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45234607
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43280445
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42700375
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.42159134
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41892676
69	Serotonergic synapse_Homo sapiens_hsa04726	0.40313131
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40297688
71	Chemokine signaling pathway_Homo sapiens_hsa04062	0.40188564
72	Nicotine addiction_Homo sapiens_hsa05033	0.39032249
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38934227
74	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38557919
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37624173
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37282809
77	Herpes simplex infection_Homo sapiens_hsa05168	0.36584048
78	Regulation of autophagy_Homo sapiens_hsa04140	0.36505465
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.35275644
80	Tuberculosis_Homo sapiens_hsa05152	0.33437379
81	Circadian entrainment_Homo sapiens_hsa04713	0.33259955
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32402724
83	Taste transduction_Homo sapiens_hsa04742	0.32371768
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.30168544
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29276383
86	Purine metabolism_Homo sapiens_hsa00230	0.25734451
87	Toxoplasmosis_Homo sapiens_hsa05145	0.22735949
88	Pertussis_Homo sapiens_hsa05133	0.22702741
89	Gastric acid secretion_Homo sapiens_hsa04971	0.21566038
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20770721
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.18790213
92	Propanoate metabolism_Homo sapiens_hsa00640	0.18522526
93	HTLV-I infection_Homo sapiens_hsa05166	0.18165668
94	Alcoholism_Homo sapiens_hsa05034	0.17634743
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.16645544
96	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.16006118
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.15143257
98	Influenza A_Homo sapiens_hsa05164	0.15131122
99	Basal transcription factors_Homo sapiens_hsa03022	0.14027726
100	Metabolic pathways_Homo sapiens_hsa01100	0.13210943

RPL23AP78

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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