ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.35964779
2	platelet dense granule organization (GO:0060155)	4.35543687
3	regulation of cilium movement (GO:0003352)	3.95668117
4	protein complex biogenesis (GO:0070271)	3.67866851
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53111399
6	NADH dehydrogenase complex assembly (GO:0010257)	3.53111399
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53111399
8	signal peptide processing (GO:0006465)	3.50964495
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.46349088
10	respiratory chain complex IV assembly (GO:0008535)	3.45483095
11	protein localization to cilium (GO:0061512)	3.41979474
12	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.41829615
13	negative regulation of appetite (GO:0032099)	3.34754229
14	negative regulation of response to food (GO:0032096)	3.34754229
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.29947140
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29607760
17	photoreceptor cell maintenance (GO:0045494)	3.27543709
18	epithelial cilium movement (GO:0003351)	3.25804972
19	dopamine transport (GO:0015872)	3.24591576
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23353223
21	DNA double-strand break processing (GO:0000729)	3.21941240
22	anterograde synaptic vesicle transport (GO:0048490)	3.18130006
23	cilium morphogenesis (GO:0060271)	3.15457640
24	axoneme assembly (GO:0035082)	3.14436680
25	cilium movement (GO:0003341)	3.08021395
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.02146467
27	negative regulation of mast cell activation (GO:0033004)	3.01675996
28	intraciliary transport (GO:0042073)	3.00761755
29	nonmotile primary cilium assembly (GO:0035058)	2.97216352
30	proteasome assembly (GO:0043248)	2.95918428
31	neural tube formation (GO:0001841)	2.92712002
32	prenylation (GO:0097354)	2.92515537
33	protein prenylation (GO:0018342)	2.92515537
34	indolalkylamine metabolic process (GO:0006586)	2.89009338
35	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.88999047
36	cytochrome complex assembly (GO:0017004)	2.88475466
37	cullin deneddylation (GO:0010388)	2.88039198
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.86396570
39	relaxation of smooth muscle (GO:0044557)	2.85499657
40	cilium organization (GO:0044782)	2.80206055
41	retinal cone cell development (GO:0046549)	2.77243613
42	amino acid salvage (GO:0043102)	2.76761951
43	L-methionine salvage (GO:0071267)	2.76761951
44	L-methionine biosynthetic process (GO:0071265)	2.76761951
45	cilium assembly (GO:0042384)	2.75722362
46	gamma-aminobutyric acid transport (GO:0015812)	2.75608408
47	negative regulation of protein localization to cell surface (GO:2000009)	2.74467460
48	termination of RNA polymerase III transcription (GO:0006386)	2.73281339
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.73281339
50	negative regulation of heart rate (GO:0010459)	2.72504625
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70902674
52	behavioral response to ethanol (GO:0048149)	2.67567058
53	cellular biogenic amine catabolic process (GO:0042402)	2.66406510
54	amine catabolic process (GO:0009310)	2.66406510
55	positive regulation of protein homodimerization activity (GO:0090073)	2.65840010
56	cilium or flagellum-dependent cell motility (GO:0001539)	2.62238968
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61980230
58	indole-containing compound catabolic process (GO:0042436)	2.61154477
59	indolalkylamine catabolic process (GO:0046218)	2.61154477
60	tryptophan catabolic process (GO:0006569)	2.61154477
61	reciprocal meiotic recombination (GO:0007131)	2.58346869
62	reciprocal DNA recombination (GO:0035825)	2.58346869
63	detection of light stimulus involved in visual perception (GO:0050908)	2.57988811
64	detection of light stimulus involved in sensory perception (GO:0050962)	2.57988811
65	protein deneddylation (GO:0000338)	2.57847521
66	kynurenine metabolic process (GO:0070189)	2.57714029
67	electron transport chain (GO:0022900)	2.57468395
68	respiratory electron transport chain (GO:0022904)	2.57265634
69	pyrimidine nucleobase catabolic process (GO:0006208)	2.56829038
70	behavioral response to nicotine (GO:0035095)	2.54908139
71	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.54046445
72	piRNA metabolic process (GO:0034587)	2.53348016
73	sequestering of actin monomers (GO:0042989)	2.53026118
74	C-terminal protein amino acid modification (GO:0018410)	2.49704788
75	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49096600
76	establishment of protein localization to Golgi (GO:0072600)	2.48684593
77	adenosine metabolic process (GO:0046085)	2.48632247
78	regulation of integrin-mediated signaling pathway (GO:2001044)	2.45000326
79	negative regulation of cation channel activity (GO:2001258)	2.44027913
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.42424486
81	nucleotide transmembrane transport (GO:1901679)	2.39633926
82	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.39052773
83	rRNA modification (GO:0000154)	2.38713306
84	neuronal action potential propagation (GO:0019227)	2.38687642
85	C-terminal protein lipidation (GO:0006501)	2.38054269
86	anterograde axon cargo transport (GO:0008089)	2.36466561
87	cellular ketone body metabolic process (GO:0046950)	2.35972047
88	protein polyglutamylation (GO:0018095)	2.33965999
89	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.33925222
90	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.33925222
91	tonic smooth muscle contraction (GO:0014820)	2.33467553
92	double-strand break repair via homologous recombination (GO:0000724)	2.33011830
93	recombinational repair (GO:0000725)	2.32870162
94	vascular smooth muscle contraction (GO:0014829)	2.31819569
95	cellular response to leptin stimulus (GO:0044320)	2.31164672
96	transmission of nerve impulse (GO:0019226)	2.30206967
97	protein-cofactor linkage (GO:0018065)	2.29663704
98	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.29456436
99	polyamine metabolic process (GO:0006595)	2.28364115
100	regulation of neurotransmitter uptake (GO:0051580)	2.28359721

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.55650604
2	VDR_22108803_ChIP-Seq_LS180_Human	2.85701966
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.85251543
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80332706
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74027043
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.73859809
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73528917
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.58702365
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44842043
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42282421
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39121476
12	EWS_26573619_Chip-Seq_HEK293_Human	2.32360311
13	P300_19829295_ChIP-Seq_ESCs_Human	2.30903749
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25588262
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14525891
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00221878
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96854113
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94928754
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90342280
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.88736069
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.86394036
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82527962
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78336213
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76992396
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74839396
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71758066
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71640938
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70771601
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.68301723
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67992464
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65736976
32	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62850612
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.61127784
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61127784
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58595303
36	AR_25329375_ChIP-Seq_VCAP_Human	1.58102791
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57733489
38	STAT3_23295773_ChIP-Seq_U87_Human	1.57415573
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54107612
40	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53777657
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53708628
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51629421
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.49263840
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43905855
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.43038951
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.42481289
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41468960
48	TCF4_23295773_ChIP-Seq_U87_Human	1.41264577
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40559537
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38596280
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38057773
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.37905180
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37641724
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37641724
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36425222
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33150741
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31876499
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.31078981
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31060900
60	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25030311
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.24057106
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22427369
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.21575095
64	TP53_16413492_ChIP-PET_HCT116_Human	1.20399441
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19429844
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18942486
67	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.18464704
68	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.18464704
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17234607
70	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16325845
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16291198
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15484166
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.15178947
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.15053113
75	JUN_21703547_ChIP-Seq_K562_Human	1.14843789
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14712781
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14712781
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13614741
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12404827
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.12261134
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11633176
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11237740
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09342568
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08942783
85	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07981224
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.07235882
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06280295
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05582667
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04210995
90	TP53_18474530_ChIP-ChIP_U2OS_Human	1.03989531
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.03869436
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03657494
93	VDR_23849224_ChIP-Seq_CD4+_Human	1.03095725
94	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02851109
95	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02743022
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02060511
97	CDX2_22108803_ChIP-Seq_LS180_Human	1.01887829
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01324809
99	P300_18555785_Chip-Seq_ESCs_Mouse	1.01240250
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00740510

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.79127694
2	MP0002736_abnormal_nociception_after	2.75880659
3	MP0008877_abnormal_DNA_methylation	2.66300398
4	MP0003136_yellow_coat_color	2.61566000
5	MP0009046_muscle_twitch	2.60154743
6	MP0001968_abnormal_touch/_nociception	2.57630706
7	MP0006276_abnormal_autonomic_nervous	2.49096580
8	MP0001984_abnormal_olfaction	2.43573947
9	MP0000569_abnormal_digit_pigmentation	2.29811564
10	MP0003195_calcinosis	2.22905995
11	MP0005551_abnormal_eye_electrophysiolog	2.17252863
12	MP0000372_irregular_coat_pigmentation	2.06254165
13	MP0002837_dystrophic_cardiac_calcinosis	2.05821096
14	MP0005171_absent_coat_pigmentation	2.01231768
15	MP0010386_abnormal_urinary_bladder	1.99942261
16	MP0005646_abnormal_pituitary_gland	1.95628752
17	MP0003880_abnormal_central_pattern	1.94364708
18	MP0005084_abnormal_gallbladder_morpholo	1.88876350
19	MP0004142_abnormal_muscle_tone	1.87900705
20	MP0002272_abnormal_nervous_system	1.84097217
21	MP0001529_abnormal_vocalization	1.77655513
22	MP0009745_abnormal_behavioral_response	1.71278683
23	MP0005253_abnormal_eye_physiology	1.66448232
24	MP0005187_abnormal_penis_morphology	1.63910836
25	MP0005464_abnormal_platelet_physiology	1.60059072
26	MP0003718_maternal_effect	1.58179523
27	MP0008872_abnormal_physiological_respon	1.57928187
28	MP0004147_increased_porphyrin_level	1.57515776
29	MP0003186_abnormal_redox_activity	1.57484475
30	MP0001486_abnormal_startle_reflex	1.56775156
31	MP0001970_abnormal_pain_threshold	1.56105241
32	MP0001905_abnormal_dopamine_level	1.55420004
33	MP0002733_abnormal_thermal_nociception	1.53729107
34	MP0006072_abnormal_retinal_apoptosis	1.48727869
35	MP0004215_abnormal_myocardial_fiber	1.48116269
36	MP0005174_abnormal_tail_pigmentation	1.45323986
37	MP0002938_white_spotting	1.43918012
38	MP0003011_delayed_dark_adaptation	1.43557144
39	MP0005410_abnormal_fertilization	1.37305454
40	MP0005645_abnormal_hypothalamus_physiol	1.36375900
41	MP0002572_abnormal_emotion/affect_behav	1.36158191
42	MP0002735_abnormal_chemical_nociception	1.35565925
43	MP0004859_abnormal_synaptic_plasticity	1.35469771
44	MP0009697_abnormal_copulation	1.33750422
45	MP0001501_abnormal_sleep_pattern	1.32134386
46	MP0000230_abnormal_systemic_arterial	1.31885350
47	MP0006292_abnormal_olfactory_placode	1.30860738
48	MP0002067_abnormal_sensory_capabilities	1.29195750
49	MP0001986_abnormal_taste_sensitivity	1.27916714
50	MP0006054_spinal_hemorrhage	1.27444095
51	MP0002090_abnormal_vision	1.27230050
52	MP0001485_abnormal_pinna_reflex	1.26484395
53	MP0003635_abnormal_synaptic_transmissio	1.23914431
54	MP0002557_abnormal_social/conspecific_i	1.23282091
55	MP0008058_abnormal_DNA_repair	1.23056946
56	MP0002734_abnormal_mechanical_nocicepti	1.21468676
57	MP0002064_seizures	1.20108926
58	MP0008775_abnormal_heart_ventricle	1.19284946
59	MP0006036_abnormal_mitochondrial_physio	1.14195992
60	MP0008789_abnormal_olfactory_epithelium	1.14129745
61	MP0002638_abnormal_pupillary_reflex	1.13488416
62	MP0004134_abnormal_chest_morphology	1.10695619
63	MP0005386_behavior/neurological_phenoty	1.07090057
64	MP0004924_abnormal_behavior	1.07090057
65	MP0004885_abnormal_endolymph	1.06135606
66	MP0002095_abnormal_skin_pigmentation	1.05982582
67	MP0001879_abnormal_lymphatic_vessel	1.04542247
68	MP0000631_abnormal_neuroendocrine_gland	1.03699563
69	MP0003787_abnormal_imprinting	1.00305474
70	MP0003950_abnormal_plasma_membrane	0.98892364
71	MP0008995_early_reproductive_senescence	0.98492115
72	MP0002063_abnormal_learning/memory/cond	0.98107296
73	MP0002234_abnormal_pharynx_morphology	0.97229372
74	MP0002184_abnormal_innervation	0.96432120
75	MP0004085_abnormal_heartbeat	0.95920750
76	MP0009780_abnormal_chondrocyte_physiolo	0.94761975
77	MP0008004_abnormal_stomach_pH	0.94721066
78	MP0000427_abnormal_hair_cycle	0.93169068
79	MP0003879_abnormal_hair_cell	0.92394176
80	MP0005499_abnormal_olfactory_system	0.91844804
81	MP0005394_taste/olfaction_phenotype	0.91844804
82	MP0005670_abnormal_white_adipose	0.90938690
83	MP0003633_abnormal_nervous_system	0.90512007
84	MP0002751_abnormal_autonomic_nervous	0.89913967
85	MP0002876_abnormal_thyroid_physiology	0.89439776
86	MP0001963_abnormal_hearing_physiology	0.86182312
87	MP0002229_neurodegeneration	0.84936751
88	MP0003137_abnormal_impulse_conducting	0.84477146
89	MP0003698_abnormal_male_reproductive	0.82536491
90	MP0002752_abnormal_somatic_nervous	0.82317390
91	MP0005423_abnormal_somatic_nervous	0.82214210
92	MP0001929_abnormal_gametogenesis	0.81859791
93	MP0002909_abnormal_adrenal_gland	0.80936955
94	MP0000778_abnormal_nervous_system	0.80881621
95	MP0004084_abnormal_cardiac_muscle	0.80772367
96	MP0001188_hyperpigmentation	0.80599593
97	MP0002295_abnormal_pulmonary_circulatio	0.80480539
98	MP0000015_abnormal_ear_pigmentation	0.79993175
99	MP0002332_abnormal_exercise_endurance	0.79592665
100	MP0006035_abnormal_mitochondrial_morpho	0.79217461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08346118
2	Medial flaring of the eyebrow (HP:0010747)	3.87041771
3	True hermaphroditism (HP:0010459)	3.80773885
4	Acute necrotizing encephalopathy (HP:0006965)	3.68561772
5	Pancreatic fibrosis (HP:0100732)	3.64225463
6	Gait imbalance (HP:0002141)	3.43436534
7	Molar tooth sign on MRI (HP:0002419)	3.38974597
8	Abnormality of midbrain morphology (HP:0002418)	3.38974597
9	Congenital primary aphakia (HP:0007707)	3.37096255
10	3-Methylglutaconic aciduria (HP:0003535)	3.34665507
11	Progressive macrocephaly (HP:0004481)	3.31072092
12	Mitochondrial inheritance (HP:0001427)	3.24853759
13	Increased CSF lactate (HP:0002490)	3.15081216
14	Acute encephalopathy (HP:0006846)	3.11766472
15	Nephrogenic diabetes insipidus (HP:0009806)	3.05691425
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.04784560
17	Nephronophthisis (HP:0000090)	2.90668901
18	Abnormal ciliary motility (HP:0012262)	2.89923187
19	Hypothermia (HP:0002045)	2.81765475
20	Renal Fanconi syndrome (HP:0001994)	2.80224389
21	Febrile seizures (HP:0002373)	2.79643813
22	Hepatic necrosis (HP:0002605)	2.75161608
23	Hepatocellular necrosis (HP:0001404)	2.73718913
24	Gaze-evoked nystagmus (HP:0000640)	2.69600030
25	Genital tract atresia (HP:0001827)	2.64683014
26	Abolished electroretinogram (ERG) (HP:0000550)	2.64490704
27	Abnormality of the renal cortex (HP:0011035)	2.62451504
28	Progressive cerebellar ataxia (HP:0002073)	2.62257989
29	Increased hepatocellular lipid droplets (HP:0006565)	2.59895507
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57672319
31	Vaginal atresia (HP:0000148)	2.56150885
32	Polyphagia (HP:0002591)	2.56117490
33	Renal cortical cysts (HP:0000803)	2.55478383
34	Hyperventilation (HP:0002883)	2.55190342
35	Lipid accumulation in hepatocytes (HP:0006561)	2.53633679
36	Abnormality of the renal medulla (HP:0100957)	2.53056512
37	Chronic hepatic failure (HP:0100626)	2.52687003
38	Type II lissencephaly (HP:0007260)	2.49152855
39	Abnormal respiratory motile cilium physiology (HP:0012261)	2.34646203
40	Methylmalonic acidemia (HP:0002912)	2.34589731
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33961977
42	Attenuation of retinal blood vessels (HP:0007843)	2.27647526
43	Absent speech (HP:0001344)	2.26568313
44	Poor coordination (HP:0002370)	2.26552713
45	Abnormality of alanine metabolism (HP:0010916)	2.24587622
46	Hyperalaninemia (HP:0003348)	2.24587622
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24587622
48	Decreased central vision (HP:0007663)	2.23967552
49	Sclerocornea (HP:0000647)	2.21589043
50	Dialeptic seizures (HP:0011146)	2.20782894
51	Retinal dysplasia (HP:0007973)	2.17146466
52	Absent/shortened dynein arms (HP:0200106)	2.16860506
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.16860506
54	Atonic seizures (HP:0010819)	2.15870412
55	Congenital stationary night blindness (HP:0007642)	2.14501782
56	Degeneration of anterior horn cells (HP:0002398)	2.13694196
57	Abnormality of the anterior horn cell (HP:0006802)	2.13694196
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13512207
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.13512207
60	Cystic liver disease (HP:0006706)	2.12998899
61	Absence seizures (HP:0002121)	2.12370471
62	Intestinal atresia (HP:0011100)	2.06424474
63	Exertional dyspnea (HP:0002875)	2.04099422
64	Abnormality of the labia minora (HP:0012880)	2.02346750
65	Aplasia/Hypoplasia of the lens (HP:0008063)	2.01026878
66	Broad-based gait (HP:0002136)	2.00508293
67	Hypoplasia of the fovea (HP:0007750)	2.00189007
68	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00189007
69	Congenital sensorineural hearing impairment (HP:0008527)	1.99676682
70	Inability to walk (HP:0002540)	1.99670281
71	Genetic anticipation (HP:0003743)	1.99254999
72	Male pseudohermaphroditism (HP:0000037)	1.99000180
73	Methylmalonic aciduria (HP:0012120)	1.98604658
74	Abnormality of renal resorption (HP:0011038)	1.95378760
75	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.94748676
76	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.94748676
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.93220295
78	Cerebral edema (HP:0002181)	1.92174394
79	Optic nerve hypoplasia (HP:0000609)	1.91965264
80	Abnormality of the fovea (HP:0000493)	1.91663507
81	Increased serum lactate (HP:0002151)	1.90625589
82	Specific learning disability (HP:0001328)	1.89174836
83	Generalized aminoaciduria (HP:0002909)	1.88859127
84	Respiratory failure (HP:0002878)	1.88404242
85	Abnormal drinking behavior (HP:0030082)	1.87925934
86	Polydipsia (HP:0001959)	1.87925934
87	Focal motor seizures (HP:0011153)	1.87875279
88	Optic disc pallor (HP:0000543)	1.87100159
89	Menorrhagia (HP:0000132)	1.87020377
90	Congenital hepatic fibrosis (HP:0002612)	1.86287014
91	Prolonged bleeding time (HP:0003010)	1.84831873
92	Constricted visual fields (HP:0001133)	1.83748206
93	Postaxial foot polydactyly (HP:0001830)	1.83464438
94	Furrowed tongue (HP:0000221)	1.81962552
95	Keratoconus (HP:0000563)	1.81899541
96	Increased corneal curvature (HP:0100692)	1.81899541
97	Rhinitis (HP:0012384)	1.81500587
98	Postaxial hand polydactyly (HP:0001162)	1.81348603
99	Cerebellar dysplasia (HP:0007033)	1.81244938
100	Anencephaly (HP:0002323)	1.79870877

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.98541070
2	MST4	3.18281216
3	BMPR1B	3.06692753
4	TRIM28	2.72950372
5	MAP4K2	2.39151697
6	MAP3K4	2.27673048
7	PINK1	2.16658971
8	CASK	2.04424794
9	ADRBK2	2.01987240
10	WNK3	1.86444069
11	ZAK	1.84860090
12	STK38L	1.84812276
13	BCR	1.80877868
14	NUAK1	1.75606013
15	MAP2K7	1.75213098
16	MAPK13	1.73914012
17	MYLK	1.64164936
18	PLK2	1.62154472
19	GRK1	1.56576393
20	ACVR1B	1.53139801
21	STK16	1.49938222
22	EIF2AK3	1.49487060
23	TNIK	1.38252935
24	PAK3	1.32885101
25	MARK1	1.31679996
26	INSRR	1.28035474
27	TAOK3	1.27763265
28	TEC	1.17916347
29	PTK2B	1.17656006
30	CSNK1G2	1.17546363
31	CSNK1G3	1.16261703
32	PIK3CG	1.15649655
33	STK39	1.14230045
34	EIF2AK1	1.11245760
35	CSNK1A1L	1.09256576
36	PKN1	1.04947840
37	TIE1	1.02713454
38	MAP3K12	1.01765246
39	ADRBK1	1.01764354
40	CSNK1G1	1.00993986
41	NTRK3	1.00463108
42	CCNB1	0.99065402
43	ERBB3	0.97634099
44	PRKCG	0.95719360
45	DYRK2	0.92717199
46	PRKCE	0.90331350
47	PLK3	0.88448084
48	SRPK1	0.78179159
49	WNK4	0.77386329
50	VRK1	0.77322143
51	GRK5	0.76914955
52	LIMK1	0.76117223
53	CAMK2A	0.73642997
54	MARK3	0.73478693
55	OXSR1	0.73329114
56	MINK1	0.73071715
57	TLK1	0.71098270
58	DAPK2	0.70246442
59	NEK1	0.68406458
60	EPHA4	0.66247166
61	MKNK2	0.62134925
62	NME1	0.59672455
63	PIM2	0.59623689
64	PHKG1	0.59088093
65	PHKG2	0.59088093
66	GRK7	0.57337008
67	STK3	0.57265364
68	CAMKK2	0.56386724
69	PDK2	0.54612234
70	TGFBR1	0.53665736
71	MKNK1	0.52752476
72	BCKDK	0.51855644
73	KSR1	0.49613991
74	BRSK2	0.49339067
75	FER	0.48073738
76	CDK19	0.47701523
77	PLK4	0.47450077
78	DYRK3	0.44688191
79	PBK	0.44578169
80	ILK	0.43944802
81	MAP3K5	0.43443704
82	PRKG1	0.43025934
83	AKT3	0.41783724
84	PLK1	0.40854768
85	PRKACB	0.40776732
86	PRKACA	0.40467823
87	CDK3	0.38960344
88	DYRK1A	0.38436265
89	PIK3CA	0.38078290
90	PNCK	0.37855448
91	RPS6KA5	0.37463381
92	ERBB2	0.36543051
93	CSNK1D	0.34974283
94	CDK8	0.34726583
95	ROCK1	0.34408380
96	EPHB2	0.33902879
97	SIK3	0.33687636
98	CAMK1	0.32415296
99	MAP2K4	0.31099675
100	STK38	0.30732693

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34036411
2	Protein export_Homo sapiens_hsa03060	3.09638464
3	Parkinsons disease_Homo sapiens_hsa05012	2.74571839
4	RNA polymerase_Homo sapiens_hsa03020	2.47049450
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41513028
6	Phototransduction_Homo sapiens_hsa04744	2.36595171
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14080796
8	Butanoate metabolism_Homo sapiens_hsa00650	2.13399188
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.12388932
10	Huntingtons disease_Homo sapiens_hsa05016	2.10445877
11	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.04843499
12	Basal transcription factors_Homo sapiens_hsa03022	2.03799600
13	Nicotine addiction_Homo sapiens_hsa05033	2.02410859
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02096632
15	Homologous recombination_Homo sapiens_hsa03440	1.91110390
16	Proteasome_Homo sapiens_hsa03050	1.88834973
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.85954033
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.82717593
19	Propanoate metabolism_Homo sapiens_hsa00640	1.80733918
20	Alzheimers disease_Homo sapiens_hsa05010	1.74867614
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54888966
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54304688
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54019785
24	Olfactory transduction_Homo sapiens_hsa04740	1.50545039
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.45692466
26	GABAergic synapse_Homo sapiens_hsa04727	1.44783407
27	Circadian entrainment_Homo sapiens_hsa04713	1.41138527
28	Morphine addiction_Homo sapiens_hsa05032	1.35579472
29	Serotonergic synapse_Homo sapiens_hsa04726	1.33085614
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31841087
31	Taste transduction_Homo sapiens_hsa04742	1.30174989
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29630311
33	Regulation of autophagy_Homo sapiens_hsa04140	1.28857265
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26235693
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25702836
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24848041
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.22207678
38	Fatty acid elongation_Homo sapiens_hsa00062	1.20723262
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.14522818
40	Purine metabolism_Homo sapiens_hsa00230	1.13235447
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12400598
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10410286
43	Mismatch repair_Homo sapiens_hsa03430	1.09171010
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.08578226
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.06681913
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03897361
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03300005
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00942195
49	RNA degradation_Homo sapiens_hsa03018	0.96974168
50	Glutathione metabolism_Homo sapiens_hsa00480	0.96843868
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.92139242
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90531577
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.90399458
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89534264
55	Sulfur metabolism_Homo sapiens_hsa00920	0.88974226
56	Peroxisome_Homo sapiens_hsa04146	0.87208010
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.85066055
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.83489367
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82841871
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81203249
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.76680103
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.73669895
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.73218523
64	Salivary secretion_Homo sapiens_hsa04970	0.71596176
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71124090
66	Insulin secretion_Homo sapiens_hsa04911	0.69423814
67	Metabolic pathways_Homo sapiens_hsa01100	0.69402950
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68599726
69	Long-term depression_Homo sapiens_hsa04730	0.67697590
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67279703
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.66953365
72	Platelet activation_Homo sapiens_hsa04611	0.64667501
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64661484
74	ABC transporters_Homo sapiens_hsa02010	0.63122074
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62801443
76	Circadian rhythm_Homo sapiens_hsa04710	0.61892859
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57657176
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57259655
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57101480
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55898996
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.53748535
82	Oocyte meiosis_Homo sapiens_hsa04114	0.52820254
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51018961
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49601293
85	Cocaine addiction_Homo sapiens_hsa05030	0.49184719
86	p53 signaling pathway_Homo sapiens_hsa04115	0.48241647
87	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45527647
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44188959
89	Cholinergic synapse_Homo sapiens_hsa04725	0.43098499
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42706682
91	Amphetamine addiction_Homo sapiens_hsa05031	0.42531641
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41866329
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.40565229
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40528137
95	Alcoholism_Homo sapiens_hsa05034	0.40370690
96	Gap junction_Homo sapiens_hsa04540	0.39585131
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39277869
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37306499
99	Retinol metabolism_Homo sapiens_hsa00830	0.36561140
100	Renin secretion_Homo sapiens_hsa04924	0.35460950

RPL23AP82

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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