ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.74857524
2	viral transcription (GO:0019083)	6.04121584
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.96439948
4	ATP synthesis coupled proton transport (GO:0015986)	5.96439948
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.88917908
6	translational termination (GO:0006415)	5.86024676
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.82846828
8	chaperone-mediated protein transport (GO:0072321)	5.77749051
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.17686777
10	cotranslational protein targeting to membrane (GO:0006613)	5.10637472
11	protein targeting to ER (GO:0045047)	5.06758857
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.93631489
13	translational elongation (GO:0006414)	4.88576148
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.85821553
15	protein localization to endoplasmic reticulum (GO:0070972)	4.83723225
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.74404237
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.74404237
18	ribosomal small subunit biogenesis (GO:0042274)	4.68389931
19	respiratory electron transport chain (GO:0022904)	4.53483365
20	electron transport chain (GO:0022900)	4.52582275
21	water-soluble vitamin biosynthetic process (GO:0042364)	4.42864449
22	protein neddylation (GO:0045116)	4.40631232
23	cellular protein complex disassembly (GO:0043624)	4.39625841
24	viral life cycle (GO:0019058)	4.33007509
25	protein complex biogenesis (GO:0070271)	4.32491313
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.19558120
27	NADH dehydrogenase complex assembly (GO:0010257)	4.19558120
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.19558120
29	maturation of SSU-rRNA (GO:0030490)	4.17200363
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.15926901
31	behavioral response to nicotine (GO:0035095)	4.12624302
32	negative regulation of heart rate (GO:0010459)	4.01987426
33	translational initiation (GO:0006413)	4.00854971
34	respiratory chain complex IV assembly (GO:0008535)	3.93765572
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.92711638
36	inner mitochondrial membrane organization (GO:0007007)	3.90863131
37	GTP biosynthetic process (GO:0006183)	3.79996559
38	translation (GO:0006412)	3.73311960
39	ribosomal large subunit biogenesis (GO:0042273)	3.71534309
40	protein complex disassembly (GO:0043241)	3.56790014
41	intracellular protein transmembrane import (GO:0044743)	3.50627317
42	termination of RNA polymerase III transcription (GO:0006386)	3.46131541
43	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.46131541
44	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.42109814
45	macromolecular complex disassembly (GO:0032984)	3.38799841
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.32295555
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31438752
48	cytochrome complex assembly (GO:0017004)	3.30129350
49	piRNA metabolic process (GO:0034587)	3.23468011
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.19740770
51	protein targeting to membrane (GO:0006612)	3.19416698
52	hydrogen ion transmembrane transport (GO:1902600)	3.19240454
53	UTP biosynthetic process (GO:0006228)	3.16281025
54	ATP biosynthetic process (GO:0006754)	3.16104708
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09846864
56	UTP metabolic process (GO:0046051)	3.07906793
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.04223314
58	cellular component biogenesis (GO:0044085)	3.02745741
59	proton transport (GO:0015992)	2.98812090
60	hydrogen transport (GO:0006818)	2.94292525
61	protein-cofactor linkage (GO:0018065)	2.92267192
62	rRNA metabolic process (GO:0016072)	2.86506369
63	L-fucose catabolic process (GO:0042355)	2.85563798
64	fucose catabolic process (GO:0019317)	2.85563798
65	L-fucose metabolic process (GO:0042354)	2.85563798
66	proteasome assembly (GO:0043248)	2.85529038
67	rRNA processing (GO:0006364)	2.85379760
68	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.84295277
69	ribonucleoprotein complex biogenesis (GO:0022613)	2.83683728
70	mRNA catabolic process (GO:0006402)	2.82912905
71	negative regulation of telomere maintenance (GO:0032205)	2.79587598
72	cell proliferation in forebrain (GO:0021846)	2.78218323
73	positive regulation of cell fate commitment (GO:0010455)	2.78143999
74	DNA deamination (GO:0045006)	2.77598261
75	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.73316263
76	protein targeting to mitochondrion (GO:0006626)	2.72905857
77	RNA catabolic process (GO:0006401)	2.66926186
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66771642
79	regulation of oxidative phosphorylation (GO:0002082)	2.62057652
80	regulation of cellular respiration (GO:0043457)	2.60832443
81	prenylation (GO:0097354)	2.60549686
82	protein prenylation (GO:0018342)	2.60549686
83	establishment of protein localization to mitochondrion (GO:0072655)	2.57639228
84	regulation of immunoglobulin secretion (GO:0051023)	2.56547250
85	pseudouridine synthesis (GO:0001522)	2.56232775
86	protein localization to mitochondrion (GO:0070585)	2.55857963
87	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52802630
88	regulation of meiosis I (GO:0060631)	2.51854775
89	positive regulation of prostaglandin secretion (GO:0032308)	2.51679185
90	nonmotile primary cilium assembly (GO:0035058)	2.48671694
91	intracellular protein transmembrane transport (GO:0065002)	2.46636838
92	chromatin remodeling at centromere (GO:0031055)	2.41609899
93	positive regulation of circadian rhythm (GO:0042753)	2.41104754
94	nucleoside triphosphate biosynthetic process (GO:0009142)	2.40261018
95	tRNA processing (GO:0008033)	2.38549341
96	DNA methylation involved in gamete generation (GO:0043046)	2.37991101
97	DNA damage response, detection of DNA damage (GO:0042769)	2.37830134
98	centriole replication (GO:0007099)	2.37404657
99	tongue development (GO:0043586)	2.37195591
100	platelet dense granule organization (GO:0060155)	2.36464977

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.57804361
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.29620241
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.06029677
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71557965
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52689610
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.14730578
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97466637
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79627971
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.74856378
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.60843963
11	VDR_22108803_ChIP-Seq_LS180_Human	2.48447108
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.47868019
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40583978
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34124711
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.32153473
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.27882892
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.19683031
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02343540
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00309867
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.99557358
21	EWS_26573619_Chip-Seq_HEK293_Human	1.92296837
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88295708
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.79027244
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76880855
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.72045568
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72045090
27	FUS_26573619_Chip-Seq_HEK293_Human	1.67789816
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59705708
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59146732
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.58779223
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.57707550
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57158310
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.53589468
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50240488
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45759832
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44595328
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44131802
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43444841
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42566307
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39341842
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34143652
42	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31155444
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29739163
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29739163
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29581646
46	P300_19829295_ChIP-Seq_ESCs_Human	1.27775993
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27689733
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23870272
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.20123688
50	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.14460810
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14013683
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12115218
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11054528
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10323562
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10323562
56	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.09961519
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09789380
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09331540
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09116177
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08593037
61	NCOR_22424771_ChIP-Seq_293T_Human	1.07169324
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05112632
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04732285
64	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04551339
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.01970419
66	AR_20517297_ChIP-Seq_VCAP_Human	1.01776917
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.01763402
68	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00998838
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00627924
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.99919579
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99540384
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99050785
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97494434
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97251046
75	CBP_20019798_ChIP-Seq_JUKART_Human	0.97251046
76	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95914974
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93232225
78	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90806313
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.90653082
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.90250840
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.89334352
82	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89171167
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.88095521
84	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.87959328
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.87610127
86	GBX2_23144817_ChIP-Seq_PC3_Human	0.87462336
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.85308324
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.84641445
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84110074
90	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.84049552
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82832059
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.82465130
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.81791108
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.81244348
95	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.81187445
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.80967526
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.80909163
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.80842673
99	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.79715316
100	DCP1A_22483619_ChIP-Seq_HELA_Human	0.79430788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.75832500
2	MP0006292_abnormal_olfactory_placode	3.81835420
3	MP0008877_abnormal_DNA_methylation	3.33179454
4	MP0004142_abnormal_muscle_tone	3.00364699
5	MP0006072_abnormal_retinal_apoptosis	2.62486678
6	MP0003787_abnormal_imprinting	2.48745212
7	MP0001835_abnormal_antigen_presentation	2.42911520
8	MP0001485_abnormal_pinna_reflex	2.38412684
9	MP0002653_abnormal_ependyma_morphology	2.34829959
10	MP0003786_premature_aging	2.24743317
11	MP0008875_abnormal_xenobiotic_pharmacok	2.11410887
12	MP0003806_abnormal_nucleotide_metabolis	1.99572735
13	MP0005551_abnormal_eye_electrophysiolog	1.92939931
14	MP0008872_abnormal_physiological_respon	1.82820245
15	MP0001968_abnormal_touch/_nociception	1.78510560
16	MP0005671_abnormal_response_to	1.78421572
17	MP0003011_delayed_dark_adaptation	1.67250061
18	MP0008789_abnormal_olfactory_epithelium	1.63499816
19	MP0002102_abnormal_ear_morphology	1.54537752
20	MP0005389_reproductive_system_phenotype	1.53138613
21	MP0001293_anophthalmia	1.52397023
22	MP0003136_yellow_coat_color	1.49981445
23	MP0005646_abnormal_pituitary_gland	1.49530661
24	MP0008995_early_reproductive_senescence	1.48353644
25	MP0004147_increased_porphyrin_level	1.47761091
26	MP0003880_abnormal_central_pattern	1.46934831
27	MP0002837_dystrophic_cardiac_calcinosis	1.46040570
28	MP0000566_synostosis	1.43571265
29	MP0002272_abnormal_nervous_system	1.42428903
30	MP0003195_calcinosis	1.41742527
31	MP0009745_abnormal_behavioral_response	1.41212563
32	MP0002160_abnormal_reproductive_system	1.39597735
33	MP0005499_abnormal_olfactory_system	1.36833930
34	MP0005394_taste/olfaction_phenotype	1.36833930
35	MP0004885_abnormal_endolymph	1.34581797
36	MP0002736_abnormal_nociception_after	1.33718285
37	MP0004742_abnormal_vestibular_system	1.32936546
38	MP0003121_genomic_imprinting	1.30326254
39	MP0003646_muscle_fatigue	1.29941795
40	MP0002163_abnormal_gland_morphology	1.28126159
41	MP0003718_maternal_effect	1.26627099
42	MP0001529_abnormal_vocalization	1.25396507
43	MP0002277_abnormal_respiratory_mucosa	1.24020539
44	MP0002148_abnormal_hypersensitivity_rea	1.23497043
45	MP0002095_abnormal_skin_pigmentation	1.23454886
46	MP0006276_abnormal_autonomic_nervous	1.22776740
47	MP0001919_abnormal_reproductive_system	1.21565207
48	MP0005253_abnormal_eye_physiology	1.20967455
49	MP0001873_stomach_inflammation	1.20347333
50	MP0005367_renal/urinary_system_phenotyp	1.18818046
51	MP0000516_abnormal_urinary_system	1.18818046
52	MP0002938_white_spotting	1.15662084
53	MP0001790_abnormal_immune_system	1.14146415
54	MP0005387_immune_system_phenotype	1.14146415
55	MP0003186_abnormal_redox_activity	1.13905670
56	MP0000372_irregular_coat_pigmentation	1.11343463
57	MP0002210_abnormal_sex_determination	1.11097141
58	MP0005084_abnormal_gallbladder_morpholo	1.06624256
59	MP0009046_muscle_twitch	1.06115730
60	MP0009785_altered_susceptibility_to	1.05232507
61	MP0001501_abnormal_sleep_pattern	1.04455190
62	MP0003122_maternal_imprinting	1.04131962
63	MP0001984_abnormal_olfaction	1.02639901
64	MP0003936_abnormal_reproductive_system	1.00678717
65	MP0002557_abnormal_social/conspecific_i	1.00571392
66	MP0000049_abnormal_middle_ear	0.99080548
67	MP0001905_abnormal_dopamine_level	0.95635177
68	MP0008058_abnormal_DNA_repair	0.95518032
69	MP0002876_abnormal_thyroid_physiology	0.95450080
70	MP0002822_catalepsy	0.95410548
71	MP0004145_abnormal_muscle_electrophysio	0.94753920
72	MP0001970_abnormal_pain_threshold	0.93843171
73	MP0002138_abnormal_hepatobiliary_system	0.93693669
74	MP0002572_abnormal_emotion/affect_behav	0.93576526
75	MP0006036_abnormal_mitochondrial_physio	0.93507143
76	MP0000653_abnormal_sex_gland	0.93417568
77	MP0000631_abnormal_neuroendocrine_gland	0.90728599
78	MP0001800_abnormal_humoral_immune	0.88969569
79	MP0001486_abnormal_startle_reflex	0.88198544
80	MP0001440_abnormal_grooming_behavior	0.87731275
81	MP0005195_abnormal_posterior_eye	0.87444870
82	MP0005085_abnormal_gallbladder_physiolo	0.87235270
83	MP0001145_abnormal_male_reproductive	0.87105952
84	MP0001929_abnormal_gametogenesis	0.84909088
85	MP0001986_abnormal_taste_sensitivity	0.83287384
86	MP0005167_abnormal_blood-brain_barrier	0.83024128
87	MP0002734_abnormal_mechanical_nocicepti	0.82228057
88	MP0001502_abnormal_circadian_rhythm	0.81208002
89	MP0001119_abnormal_female_reproductive	0.79695985
90	MP0000427_abnormal_hair_cycle	0.79666482
91	MP0010386_abnormal_urinary_bladder	0.79348067
92	MP0002733_abnormal_thermal_nociception	0.79154363
93	MP0003693_abnormal_embryo_hatching	0.78819458
94	MP0005332_abnormal_amino_acid	0.75685650
95	MP0005645_abnormal_hypothalamus_physiol	0.75104077
96	MP0005174_abnormal_tail_pigmentation	0.73267089
97	MP0001963_abnormal_hearing_physiology	0.72188268
98	MP0008007_abnormal_cellular_replicative	0.72042675
99	MP0001764_abnormal_homeostasis	0.71458380
100	MP0003938_abnormal_ear_development	0.69586277

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.01743116
2	Mitochondrial inheritance (HP:0001427)	4.55541757
3	Reticulocytopenia (HP:0001896)	4.45862633
4	Congenital, generalized hypertrichosis (HP:0004540)	4.42868172
5	Acute encephalopathy (HP:0006846)	4.42143874
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.27731665
7	Progressive macrocephaly (HP:0004481)	4.26148595
8	Increased hepatocellular lipid droplets (HP:0006565)	4.24521445
9	Lipid accumulation in hepatocytes (HP:0006561)	4.10221875
10	Increased CSF lactate (HP:0002490)	4.06509927
11	3-Methylglutaconic aciduria (HP:0003535)	3.87538947
12	Hepatocellular necrosis (HP:0001404)	3.84944103
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.31529789
14	Renal Fanconi syndrome (HP:0001994)	3.19856970
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.15134765
16	Hepatic necrosis (HP:0002605)	3.09426636
17	Abnormality of the labia minora (HP:0012880)	3.05968840
18	Exertional dyspnea (HP:0002875)	3.04990659
19	Medial flaring of the eyebrow (HP:0010747)	2.90679336
20	Cerebral edema (HP:0002181)	2.89535174
21	Abnormal number of erythroid precursors (HP:0012131)	2.89051619
22	Pancreatic cysts (HP:0001737)	2.87002940
23	Leukodystrophy (HP:0002415)	2.85533520
24	Methylmalonic acidemia (HP:0002912)	2.84568168
25	Hyperglycinemia (HP:0002154)	2.83570851
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.79600593
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.79600593
28	Pancreatic fibrosis (HP:0100732)	2.77209337
29	Optic disc pallor (HP:0000543)	2.75040386
30	Macrocytic anemia (HP:0001972)	2.71570091
31	Increased intramyocellular lipid droplets (HP:0012240)	2.64468366
32	Hypothermia (HP:0002045)	2.63091974
33	Septo-optic dysplasia (HP:0100842)	2.51331174
34	Chromsome breakage (HP:0040012)	2.50789454
35	Methylmalonic aciduria (HP:0012120)	2.39721413
36	Congenital stationary night blindness (HP:0007642)	2.38774350
37	Stomatitis (HP:0010280)	2.35832028
38	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31899158
39	Increased serum lactate (HP:0002151)	2.31482552
40	Meckel diverticulum (HP:0002245)	2.29892475
41	Molar tooth sign on MRI (HP:0002419)	2.28516325
42	Abnormality of midbrain morphology (HP:0002418)	2.28516325
43	Increased muscle lipid content (HP:0009058)	2.28261820
44	Pendular nystagmus (HP:0012043)	2.26901277
45	Lactic acidosis (HP:0003128)	2.26392713
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25124494
47	Respiratory failure (HP:0002878)	2.22948546
48	Gait imbalance (HP:0002141)	2.21768075
49	Delayed CNS myelination (HP:0002188)	2.20448910
50	Stenosis of the external auditory canal (HP:0000402)	2.20117717
51	Congenital primary aphakia (HP:0007707)	2.20094354
52	Nephronophthisis (HP:0000090)	2.17158643
53	Pallor (HP:0000980)	2.15260699
54	True hermaphroditism (HP:0010459)	2.15030610
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.14648232
56	Aplastic anemia (HP:0001915)	2.14239234
57	Abnormality of the ileum (HP:0001549)	2.13865386
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12396946
59	Abnormality of alanine metabolism (HP:0010916)	2.12396946
60	Hyperalaninemia (HP:0003348)	2.12396946
61	Absent thumb (HP:0009777)	2.11356562
62	IgG deficiency (HP:0004315)	2.10145692
63	Pancytopenia (HP:0001876)	2.09572970
64	Woolly hair (HP:0002224)	2.08619802
65	Asplenia (HP:0001746)	2.08425911
66	Abnormal rod and cone electroretinograms (HP:0008323)	2.07790883
67	Lethargy (HP:0001254)	2.06961367
68	Abolished electroretinogram (ERG) (HP:0000550)	2.06290984
69	Abnormality of serine family amino acid metabolism (HP:0010894)	2.05078863
70	Abnormality of glycine metabolism (HP:0010895)	2.05078863
71	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04510391
72	Hypoplasia of the radius (HP:0002984)	2.03343745
73	Abnormality of renal resorption (HP:0011038)	2.02215712
74	Postaxial foot polydactyly (HP:0001830)	2.02068104
75	Respiratory difficulties (HP:0002880)	2.01267923
76	Hyperglycinuria (HP:0003108)	2.00925257
77	Oligodactyly (hands) (HP:0001180)	1.98598989
78	Inability to walk (HP:0002540)	1.97412509
79	Nephrogenic diabetes insipidus (HP:0009806)	1.92857197
80	Exercise intolerance (HP:0003546)	1.92681995
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88237808
82	Cleft eyelid (HP:0000625)	1.87181580
83	Abnormality of the preputium (HP:0100587)	1.86995013
84	Hyperphosphaturia (HP:0003109)	1.83158318
85	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.82122813
86	Colon cancer (HP:0003003)	1.81885373
87	Abnormality of the renal cortex (HP:0011035)	1.81695375
88	Bilateral microphthalmos (HP:0007633)	1.79320634
89	Vaginal atresia (HP:0000148)	1.77857977
90	Absent/shortened dynein arms (HP:0200106)	1.77654262
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.77654262
92	Genital tract atresia (HP:0001827)	1.77316168
93	Horseshoe kidney (HP:0000085)	1.77119089
94	Abnormality of urine glucose concentration (HP:0011016)	1.76728588
95	Glycosuria (HP:0003076)	1.76728588
96	Supernumerary spleens (HP:0009799)	1.76012371
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74837320
98	Sclerocornea (HP:0000647)	1.73450518
99	Abnormal drinking behavior (HP:0030082)	1.73396958
100	Polydipsia (HP:0001959)	1.73396958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.74269009
2	NUAK1	3.48681820
3	TXK	3.30562964
4	TLK1	3.17772535
5	ZAK	2.88288553
6	TAOK3	2.83150083
7	STK16	2.34254311
8	GRK1	2.21798126
9	WNK4	2.18520217
10	BMPR1B	2.17448562
11	MST4	2.07787024
12	MAP4K1	2.02486344
13	ADRBK2	1.99995291
14	CDC7	1.93175710
15	CDK19	1.91174477
16	PINK1	1.81100435
17	OXSR1	1.80529830
18	VRK1	1.68523965
19	NME1	1.64394382
20	BUB1	1.62867744
21	DYRK2	1.58041416
22	FES	1.49081131
23	TSSK6	1.48400162
24	WNK3	1.47171132
25	INSRR	1.46521456
26	TAF1	1.43411657
27	STK39	1.42077498
28	NEK1	1.40392213
29	MAP3K12	1.37649315
30	TNIK	1.31054344
31	FRK	1.30205920
32	PLK3	1.27475129
33	TIE1	1.22168153
34	PHKG2	1.10304819
35	PHKG1	1.10304819
36	PNCK	1.09890434
37	BMPR2	1.09688607
38	PLK4	1.06081402
39	SRPK1	1.05336009
40	TNK2	0.99868226
41	WNK1	0.85792469
42	MKNK1	0.83131745
43	PASK	0.80777347
44	MAPK15	0.79044703
45	KIT	0.75327313
46	CSNK1G2	0.74782984
47	NME2	0.74657542
48	AURKB	0.74070909
49	EPHB2	0.71973798
50	MKNK2	0.71910767
51	DMPK	0.71679089
52	SIK2	0.71230131
53	PLK1	0.68176788
54	WEE1	0.67831282
55	MUSK	0.67311742
56	MAPKAPK5	0.67228427
57	MAP3K11	0.64269248
58	PRKCQ	0.62719777
59	CAMKK2	0.62470630
60	PLK2	0.62334749
61	CSNK1G1	0.61614159
62	PRKCG	0.61310232
63	CSNK2A2	0.59273945
64	MATK	0.57416271
65	ATR	0.56172375
66	FLT3	0.56088038
67	PKN1	0.55952671
68	MAP4K2	0.55892985
69	ERBB3	0.55860612
70	ALK	0.55496339
71	CSF1R	0.54621130
72	CAMK1	0.54176221
73	BTK	0.54067912
74	MAP2K6	0.52208481
75	LYN	0.51789299
76	RPS6KA5	0.51570715
77	IKBKB	0.50838104
78	CSNK1G3	0.50837515
79	CSNK2A1	0.50771308
80	OBSCN	0.49259548
81	STK38L	0.48972237
82	CDK3	0.47947986
83	PAK3	0.47745585
84	BCKDK	0.47382060
85	TGFBR1	0.47272166
86	ACVR1B	0.46862048
87	ADRBK1	0.46594436
88	PRKACA	0.45789758
89	TYRO3	0.43375100
90	CHEK2	0.42287197
91	LCK	0.40193577
92	DAPK3	0.40033767
93	SYK	0.39958163
94	TTK	0.37817517
95	CSNK1E	0.37471758
96	GRK5	0.35878767
97	CSNK1A1	0.35294067
98	MAPKAPK3	0.34375181
99	STK24	0.34313735
100	NLK	0.33712213

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.92717684
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.90313759
3	Parkinsons disease_Homo sapiens_hsa05012	3.40621105
4	Proteasome_Homo sapiens_hsa03050	3.30520245
5	Asthma_Homo sapiens_hsa05310	3.12334804
6	Allograft rejection_Homo sapiens_hsa05330	2.66404721
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.44006185
8	Protein export_Homo sapiens_hsa03060	2.40087198
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31416598
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.24123331
11	Huntingtons disease_Homo sapiens_hsa05016	2.22979887
12	RNA polymerase_Homo sapiens_hsa03020	2.20848835
13	Alzheimers disease_Homo sapiens_hsa05010	2.20448318
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.20039609
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.07950999
16	Cardiac muscle contraction_Homo sapiens_hsa04260	2.03178153
17	Homologous recombination_Homo sapiens_hsa03440	2.01826337
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94251080
19	Caffeine metabolism_Homo sapiens_hsa00232	1.90794928
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76173525
21	One carbon pool by folate_Homo sapiens_hsa00670	1.70246204
22	RNA degradation_Homo sapiens_hsa03018	1.57818691
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57334536
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56963510
25	Mismatch repair_Homo sapiens_hsa03430	1.56019642
26	Basal transcription factors_Homo sapiens_hsa03022	1.38348242
27	Nicotine addiction_Homo sapiens_hsa05033	1.25161466
28	Phototransduction_Homo sapiens_hsa04744	1.25094882
29	DNA replication_Homo sapiens_hsa03030	1.22381129
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.21077358
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19810746
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14582722
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.13427246
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11701007
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07101645
36	Base excision repair_Homo sapiens_hsa03410	1.06827176
37	Spliceosome_Homo sapiens_hsa03040	1.01583639
38	Purine metabolism_Homo sapiens_hsa00230	0.99555497
39	Antigen processing and presentation_Homo sapiens_hsa04612	0.98253809
40	Viral myocarditis_Homo sapiens_hsa05416	0.92152741
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90721974
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89575835
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88596173
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87685720
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82776053
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82524519
47	Peroxisome_Homo sapiens_hsa04146	0.82320252
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76606339
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.75959176
50	Propanoate metabolism_Homo sapiens_hsa00640	0.74368771
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72562642
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.72283186
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.71342993
54	RNA transport_Homo sapiens_hsa03013	0.69545836
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66193497
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66095103
57	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65313002
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.59194491
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58317941
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57449598
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57370885
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56497566
63	Sulfur metabolism_Homo sapiens_hsa00920	0.55228759
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54850345
65	Metabolic pathways_Homo sapiens_hsa01100	0.53975143
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.52650749
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52083773
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51694938
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51180805
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51137358
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50309293
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47958586
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47518727
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46446295
75	Olfactory transduction_Homo sapiens_hsa04740	0.44145472
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42262839
77	Butanoate metabolism_Homo sapiens_hsa00650	0.41198233
78	Taste transduction_Homo sapiens_hsa04742	0.40018916
79	Folate biosynthesis_Homo sapiens_hsa00790	0.39942351
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39879777
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39740810
82	Retinol metabolism_Homo sapiens_hsa00830	0.39578457
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.39320279
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38847812
85	Mineral absorption_Homo sapiens_hsa04978	0.33257702
86	Regulation of autophagy_Homo sapiens_hsa04140	0.32301817
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32152109
88	Leishmaniasis_Homo sapiens_hsa05140	0.31744051
89	Morphine addiction_Homo sapiens_hsa05032	0.29492742
90	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.28087033
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26931672
92	p53 signaling pathway_Homo sapiens_hsa04115	0.25987406
93	Fatty acid elongation_Homo sapiens_hsa00062	0.25763716
94	Glutathione metabolism_Homo sapiens_hsa00480	0.25611061
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21457058
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21033520
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.19858879
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.19355211
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.18333402
100	Insulin secretion_Homo sapiens_hsa04911	0.17616032

RPL23AP83

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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