ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	8.78261478
2	regulation of interleukin-5 production (GO:0032674)	8.71878584
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.47030886
4	regulation of mitochondrial translation (GO:0070129)	6.10167205
5	phosphatidylglycerol biosynthetic process (GO:0006655)	5.19859009
6	nephron epithelium morphogenesis (GO:0072088)	5.14001689
7	nephron tubule morphogenesis (GO:0072078)	5.14001689
8	chaperone-mediated protein transport (GO:0072321)	4.96089180
9	renal tubule morphogenesis (GO:0061333)	4.94331670
10	regulation of centriole replication (GO:0046599)	4.75050968
11	protein complex biogenesis (GO:0070271)	4.69793576
12	ribosomal large subunit biogenesis (GO:0042273)	4.56780027
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.53451247
14	ATP synthesis coupled proton transport (GO:0015986)	4.53451247
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.47803846
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.47803846
17	NADH dehydrogenase complex assembly (GO:0010257)	4.47803846
18	ribosomal small subunit biogenesis (GO:0042274)	4.42950845
19	adaptation of signaling pathway (GO:0023058)	4.37076003
20	centriole replication (GO:0007099)	4.32453817
21	cellular component biogenesis (GO:0044085)	4.28924469
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.28157101
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.28157101
24	preassembly of GPI anchor in ER membrane (GO:0016254)	4.28033294
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.27940474
26	C-terminal protein lipidation (GO:0006501)	4.22410547
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.16560392
28	DNA damage response, detection of DNA damage (GO:0042769)	4.11464396
29	ribonucleoprotein complex biogenesis (GO:0022613)	4.10029457
30	ribosome biogenesis (GO:0042254)	3.91501674
31	respiratory electron transport chain (GO:0022904)	3.83148849
32	microtubule nucleation (GO:0007020)	3.82595856
33	viral transcription (GO:0019083)	3.80469909
34	C-terminal protein amino acid modification (GO:0018410)	3.80419410
35	electron transport chain (GO:0022900)	3.77138600
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.73946697
37	translational termination (GO:0006415)	3.69213171
38	regulation of cellular respiration (GO:0043457)	3.68582374
39	neuron fate determination (GO:0048664)	3.64955017
40	tongue development (GO:0043586)	3.61492084
41	platelet dense granule organization (GO:0060155)	3.60923447
42	intracellular protein transmembrane import (GO:0044743)	3.51178184
43	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.49653143
44	nucleotide transmembrane transport (GO:1901679)	3.49212274
45	protein localization to endoplasmic reticulum (GO:0070972)	3.44814267
46	protein targeting to ER (GO:0045047)	3.44409729
47	positive regulation of action potential (GO:0045760)	3.42375275
48	cotranslational protein targeting to membrane (GO:0006613)	3.42296016
49	peptidyl-threonine dephosphorylation (GO:0035970)	3.39477491
50	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.39381934
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.29129519
52	AMP metabolic process (GO:0046033)	3.27446988
53	protein-cofactor linkage (GO:0018065)	3.27008889
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.19668055
55	rRNA modification (GO:0000154)	3.19342444
56	purine deoxyribonucleotide metabolic process (GO:0009151)	3.17006429
57	respiratory chain complex IV assembly (GO:0008535)	3.16736060
58	translational elongation (GO:0006414)	3.13590277
59	mitotic nuclear envelope reassembly (GO:0007084)	3.13563301
60	nuclear envelope reassembly (GO:0031468)	3.13563301
61	purine deoxyribonucleotide catabolic process (GO:0009155)	3.13346078
62	rRNA methylation (GO:0031167)	3.11650822
63	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.10776256
64	spliceosomal snRNP assembly (GO:0000387)	3.09870381
65	lysine metabolic process (GO:0006553)	3.09161004
66	lysine catabolic process (GO:0006554)	3.09161004
67	piRNA metabolic process (GO:0034587)	3.06998613
68	mannosylation (GO:0097502)	3.05391624
69	intracellular protein transmembrane transport (GO:0065002)	3.04560695
70	protein neddylation (GO:0045116)	3.02028442
71	base-excision repair, AP site formation (GO:0006285)	3.01976587
72	organelle disassembly (GO:1903008)	3.00447608
73	cytochrome complex assembly (GO:0017004)	2.98189181
74	response to folic acid (GO:0051593)	2.93310865
75	inner mitochondrial membrane organization (GO:0007007)	2.92037274
76	response to misfolded protein (GO:0051788)	2.91011099
77	mismatch repair (GO:0006298)	2.84629375
78	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.82696338
79	protein transmembrane transport (GO:0071806)	2.80933388
80	protein targeting to mitochondrion (GO:0006626)	2.80309305
81	phosphorelay signal transduction system (GO:0000160)	2.79761354
82	tRNA aminoacylation for protein translation (GO:0006418)	2.79037688
83	positive regulation of icosanoid secretion (GO:0032305)	2.78877501
84	regulation of memory T cell differentiation (GO:0043380)	2.78465314
85	regulation of telomerase activity (GO:0051972)	2.75989658
86	centriole assembly (GO:0098534)	2.75508737
87	tRNA aminoacylation (GO:0043039)	2.75373887
88	amino acid activation (GO:0043038)	2.75373887
89	DNA replication initiation (GO:0006270)	2.74331855
90	cellular protein complex disassembly (GO:0043624)	2.73813466
91	glycerophospholipid catabolic process (GO:0046475)	2.73516173
92	translation (GO:0006412)	2.73111108
93	viral life cycle (GO:0019058)	2.72948370
94	oxidative phosphorylation (GO:0006119)	2.71897417
95	ATP biosynthetic process (GO:0006754)	2.70080289
96	tRNA metabolic process (GO:0006399)	2.69811468
97	urinary tract smooth muscle contraction (GO:0014848)	2.69441482
98	cellular biogenic amine catabolic process (GO:0042402)	2.68260483
99	amine catabolic process (GO:0009310)	2.68260483
100	anterograde synaptic vesicle transport (GO:0048490)	2.67117320

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.91191349
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.84813619
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59453232
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.44115239
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41337670
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12933175
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83823023
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.83567248
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.76181973
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.76105522
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74258093
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.70089442
13	TP53_22573176_ChIP-Seq_HFKS_Human	2.69483510
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34851103
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.21599544
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.18763092
17	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.12429700
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.95242657
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93202585
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92871429
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.91025234
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89880989
23	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.88691931
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87629965
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.81037752
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.80533407
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77665694
28	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.68693959
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66858795
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60309673
31	EWS_26573619_Chip-Seq_HEK293_Human	1.59109159
32	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.55050957
33	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.55050957
34	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.55050957
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53909184
36	FUS_26573619_Chip-Seq_HEK293_Human	1.52917660
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.51560826
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51543959
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51124974
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50438281
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.49479369
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.46481102
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45193816
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45132272
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43882981
46	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.41794937
47	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.41728787
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39974942
49	AR_20517297_ChIP-Seq_VCAP_Human	1.35320105
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33800131
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32183030
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.31885406
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.28293449
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.27882716
55	NCOR_22424771_ChIP-Seq_293T_Human	1.27713550
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27617476
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.27199393
58	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.26856234
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25338690
60	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.24963507
61	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.24390411
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18198759
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.15666031
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14965861
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10420620
66	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09197680
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07774205
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07680778
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06999481
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04626580
71	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.01054841
72	VDR_22108803_ChIP-Seq_LS180_Human	0.97946189
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97221810
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.95559371
75	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95547555
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95029971
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.94983552
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94981850
79	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.94688144
80	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93960838
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93753933
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93692698
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.92905541
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.91778660
85	CIITA_25753668_ChIP-Seq_RAJI_Human	0.91306210
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90231798
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89637925
88	P300_19829295_ChIP-Seq_ESCs_Human	0.89069518
89	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88957295
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87973673
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87633833
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84412881
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83188761
94	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.81806856
95	AR_25329375_ChIP-Seq_VCAP_Human	0.81435267
96	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.81230195
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.79317786
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.77594760
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.77594760
100	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.77168919

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005379_endocrine/exocrine_gland_phen	3.28968934
2	MP0003122_maternal_imprinting	3.12895485
3	MP0008877_abnormal_DNA_methylation	3.06985479
4	MP0002653_abnormal_ependyma_morphology	2.97313405
5	MP0002736_abnormal_nociception_after	2.78600603
6	MP0009379_abnormal_foot_pigmentation	2.66817307
7	MP0004142_abnormal_muscle_tone	2.42570660
8	MP0003195_calcinosis	2.33857868
9	MP0001968_abnormal_touch/_nociception	2.32665535
10	MP0006072_abnormal_retinal_apoptosis	2.31726059
11	MP0004147_increased_porphyrin_level	2.24958363
12	MP0001986_abnormal_taste_sensitivity	2.20494724
13	MP0003136_yellow_coat_color	2.11174022
14	MP0003121_genomic_imprinting	2.02403293
15	MP0002160_abnormal_reproductive_system	1.95853667
16	MP0008058_abnormal_DNA_repair	1.85878389
17	MP0002277_abnormal_respiratory_mucosa	1.82740465
18	MP0000685_abnormal_immune_system	1.76900382
19	MP0000631_abnormal_neuroendocrine_gland	1.75522510
20	MP0001348_abnormal_lacrimal_gland	1.73889722
21	MP0003880_abnormal_central_pattern	1.71662951
22	MP0000372_irregular_coat_pigmentation	1.71532589
23	MP0001919_abnormal_reproductive_system	1.71455203
24	MP0001485_abnormal_pinna_reflex	1.67581814
25	MP0003123_paternal_imprinting	1.64510673
26	MP0002733_abnormal_thermal_nociception	1.64022989
27	MP0000639_abnormal_adrenal_gland	1.58143503
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.54887216
29	MP0006036_abnormal_mitochondrial_physio	1.53082870
30	MP0003693_abnormal_embryo_hatching	1.50885428
31	MP0008872_abnormal_physiological_respon	1.50234842
32	MP0006276_abnormal_autonomic_nervous	1.49684166
33	MP0002837_dystrophic_cardiac_calcinosis	1.43047550
34	MP0005389_reproductive_system_phenotype	1.41404428
35	MP0000427_abnormal_hair_cycle	1.40880130
36	MP0003786_premature_aging	1.40183200
37	MP0008875_abnormal_xenobiotic_pharmacok	1.39063485
38	MP0004043_abnormal_pH_regulation	1.35838289
39	MP0008260_abnormal_autophagy	1.30533296
40	MP0001984_abnormal_olfaction	1.30137667
41	MP0001970_abnormal_pain_threshold	1.29917638
42	MP0003646_muscle_fatigue	1.29522894
43	MP0001440_abnormal_grooming_behavior	1.25578836
44	MP0005551_abnormal_eye_electrophysiolog	1.25531523
45	MP0001293_anophthalmia	1.24900214
46	MP0005075_abnormal_melanosome_morpholog	1.22571556
47	MP0008789_abnormal_olfactory_epithelium	1.21103137
48	MP0005671_abnormal_response_to	1.14759663
49	MP0005332_abnormal_amino_acid	1.14434226
50	MP0005408_hypopigmentation	1.14165312
51	MP0008004_abnormal_stomach_pH	1.13174436
52	MP0002734_abnormal_mechanical_nocicepti	1.11622770
53	MP0001764_abnormal_homeostasis	1.11405953
54	MP0002254_reproductive_system_inflammat	1.10970973
55	MP0005636_abnormal_mineral_homeostasis	1.10893412
56	MP0003186_abnormal_redox_activity	1.10320049
57	MP0002272_abnormal_nervous_system	1.09284986
58	MP0006035_abnormal_mitochondrial_morpho	1.05397154
59	MP0004215_abnormal_myocardial_fiber	1.05195534
60	MP0006292_abnormal_olfactory_placode	1.04494428
61	MP0000470_abnormal_stomach_morphology	1.02744181
62	MP0002572_abnormal_emotion/affect_behav	1.01575589
63	MP0002938_white_spotting	1.00005600
64	MP0000613_abnormal_salivary_gland	0.99855013
65	MP0002210_abnormal_sex_determination	0.99377861
66	MP0001270_distended_abdomen	0.98834365
67	MP0004885_abnormal_endolymph	0.98444136
68	MP0008995_early_reproductive_senescence	0.97815806
69	MP0003718_maternal_effect	0.95756849
70	MP0005499_abnormal_olfactory_system	0.94070481
71	MP0005394_taste/olfaction_phenotype	0.94070481
72	MP0001905_abnormal_dopamine_level	0.93969603
73	MP0000015_abnormal_ear_pigmentation	0.93011562
74	MP0001529_abnormal_vocalization	0.92161062
75	MP0002102_abnormal_ear_morphology	0.91976034
76	MP0002095_abnormal_skin_pigmentation	0.91253359
77	MP0002909_abnormal_adrenal_gland	0.90356439
78	MP0001188_hyperpigmentation	0.89941203
79	MP0005084_abnormal_gallbladder_morpholo	0.89123652
80	MP0005423_abnormal_somatic_nervous	0.86981091
81	MP0004019_abnormal_vitamin_homeostasis	0.85318441
82	MP0005253_abnormal_eye_physiology	0.84984939
83	MP0002163_abnormal_gland_morphology	0.83057336
84	MP0003938_abnormal_ear_development	0.82873650
85	MP0003252_abnormal_bile_duct	0.82639734
86	MP0002184_abnormal_innervation	0.81240625
87	MP0002138_abnormal_hepatobiliary_system	0.80252942
88	MP0005195_abnormal_posterior_eye	0.80122019
89	MP0003942_abnormal_urinary_system	0.79650666
90	MP0003806_abnormal_nucleotide_metabolis	0.78317266
91	MP0009745_abnormal_behavioral_response	0.77343949
92	MP0010329_abnormal_lipoprotein_level	0.77091865
93	MP0002735_abnormal_chemical_nociception	0.76368268
94	MP0004145_abnormal_muscle_electrophysio	0.76011494
95	MP0003137_abnormal_impulse_conducting	0.75618433
96	MP0005645_abnormal_hypothalamus_physiol	0.75453418
97	MP0001664_abnormal_digestion	0.73069529
98	MP0000026_abnormal_inner_ear	0.72713961
99	MP0002139_abnormal_hepatobiliary_system	0.72115307
100	MP0002229_neurodegeneration	0.70934906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.71281444
2	Lipid accumulation in hepatocytes (HP:0006561)	4.64245409
3	Reticulocytopenia (HP:0001896)	4.59219773
4	Increased hepatocellular lipid droplets (HP:0006565)	4.43455924
5	Retinal atrophy (HP:0001105)	3.94479394
6	Tubular atrophy (HP:0000092)	3.83474065
7	Acute encephalopathy (HP:0006846)	3.79830537
8	Oligomenorrhea (HP:0000876)	3.74690800
9	Acute necrotizing encephalopathy (HP:0006965)	3.66959143
10	Nephronophthisis (HP:0000090)	3.63034011
11	Renal Fanconi syndrome (HP:0001994)	3.54948953
12	Medial flaring of the eyebrow (HP:0010747)	3.43649075
13	Abnormal drinking behavior (HP:0030082)	3.41659723
14	Polydipsia (HP:0001959)	3.41659723
15	Abnormality of the anterior horn cell (HP:0006802)	3.38204809
16	Degeneration of anterior horn cells (HP:0002398)	3.38204809
17	Abnormality of glycolysis (HP:0004366)	3.35676171
18	Mitochondrial inheritance (HP:0001427)	3.31883188
19	IgM deficiency (HP:0002850)	3.31842048
20	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30071337
21	Progressive macrocephaly (HP:0004481)	3.16902611
22	Abnormality of the renal cortex (HP:0011035)	3.01342127
23	Molar tooth sign on MRI (HP:0002419)	3.00344650
24	Abnormality of midbrain morphology (HP:0002418)	3.00344650
25	Increased serum pyruvate (HP:0003542)	2.99417234
26	Generalized aminoaciduria (HP:0002909)	2.92737035
27	Increased CSF lactate (HP:0002490)	2.92025963
28	Gonadotropin excess (HP:0000837)	2.83312753
29	Hypoglycemic coma (HP:0001325)	2.81810318
30	Increased intramyocellular lipid droplets (HP:0012240)	2.77633706
31	Nausea (HP:0002018)	2.74977929
32	Delayed CNS myelination (HP:0002188)	2.73982988
33	Type 2 muscle fiber atrophy (HP:0003554)	2.70313951
34	Metaphyseal cupping (HP:0003021)	2.69037701
35	Increased muscle lipid content (HP:0009058)	2.64802553
36	Hyperalaninemia (HP:0003348)	2.64666161
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64666161
38	Abnormality of alanine metabolism (HP:0010916)	2.64666161
39	Septo-optic dysplasia (HP:0100842)	2.60644452
40	Abnormal tarsal ossification (HP:0008369)	2.54860538
41	Abnormality of renal resorption (HP:0011038)	2.53007903
42	Posterior subcapsular cataract (HP:0007787)	2.49765267
43	Hepatic necrosis (HP:0002605)	2.48562661
44	Renal cortical cysts (HP:0000803)	2.47026475
45	Conical tooth (HP:0000698)	2.43907381
46	Abnormality of the renal medulla (HP:0100957)	2.43858704
47	Cerebral edema (HP:0002181)	2.36842915
48	Abnormality of urine glucose concentration (HP:0011016)	2.29562375
49	Glycosuria (HP:0003076)	2.29562375
50	Exertional dyspnea (HP:0002875)	2.28253957
51	Muscle fiber atrophy (HP:0100295)	2.27613619
52	Increased serum lactate (HP:0002151)	2.26330776
53	Macrocytic anemia (HP:0001972)	2.23264210
54	Palpitations (HP:0001962)	2.22639716
55	Polyuria (HP:0000103)	2.20560327
56	Small epiphyses (HP:0010585)	2.16894148
57	Abnormality of the vertebral endplates (HP:0005106)	2.14781394
58	Hip dysplasia (HP:0001385)	2.14146123
59	Hyperphosphaturia (HP:0003109)	2.12690339
60	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10531004
61	Abnormality of placental membranes (HP:0011409)	2.10102931
62	Amniotic constriction ring (HP:0009775)	2.10102931
63	Spinal muscular atrophy (HP:0007269)	2.07443127
64	Humeroradial synostosis (HP:0003041)	2.05142281
65	Synostosis involving the elbow (HP:0003938)	2.05142281
66	Hepatocellular necrosis (HP:0001404)	2.00950269
67	Poor suck (HP:0002033)	2.00664560
68	Stenosis of the external auditory canal (HP:0000402)	2.00439395
69	Leukodystrophy (HP:0002415)	1.98925209
70	Tongue fasciculations (HP:0001308)	1.97470297
71	Irregular vertebral endplates (HP:0003301)	1.96768769
72	Abnormal urine phosphate concentration (HP:0012599)	1.96402440
73	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.96151734
74	Lactic acidosis (HP:0003128)	1.94872106
75	Hypogonadotrophic hypogonadism (HP:0000044)	1.93524325
76	Respiratory difficulties (HP:0002880)	1.93501693
77	Renal tubular dysfunction (HP:0000124)	1.87544142
78	X-linked dominant inheritance (HP:0001423)	1.84887933
79	Congenital, generalized hypertrichosis (HP:0004540)	1.83253516
80	Pheochromocytoma (HP:0002666)	1.80955288
81	Absent septum pellucidum (HP:0001331)	1.80396107
82	Exercise intolerance (HP:0003546)	1.79489773
83	Agitation (HP:0000713)	1.79148391
84	Abnormality of DNA repair (HP:0003254)	1.78766004
85	Clumsiness (HP:0002312)	1.78455154
86	Hypoplasia of the radius (HP:0002984)	1.77309337
87	Delayed gross motor development (HP:0002194)	1.76836018
88	Metabolic acidosis (HP:0001942)	1.76285975
89	Abnormality of the septum pellucidum (HP:0007375)	1.74338281
90	Hyperglycinemia (HP:0002154)	1.73913799
91	Tubulointerstitial fibrosis (HP:0005576)	1.73542665
92	Myotonia (HP:0002486)	1.73324718
93	Abnormal urine output (HP:0012590)	1.72841780
94	Cupped ribs (HP:0000887)	1.72080633
95	Absent thumb (HP:0009777)	1.71046794
96	Stage 5 chronic kidney disease (HP:0003774)	1.69097237
97	Choanal stenosis (HP:0000452)	1.67695203
98	Abnormality of renal excretion (HP:0011036)	1.65643317
99	Hemiplegia (HP:0002301)	1.65609539
100	Ulnar bowing (HP:0003031)	1.63243350

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	9.89283748
2	NUAK1	5.83435204
3	PLK4	5.00167022
4	TRIM28	3.98725182
5	STK3	2.88505298
6	WNK4	2.54858530
7	MST4	2.49235438
8	TIE1	2.28545381
9	PTK2B	2.24469466
10	VRK2	2.22030143
11	PLK2	1.94967118
12	VRK1	1.89422461
13	STK16	1.84081108
14	FGFR2	1.74582982
15	MAP3K12	1.54993102
16	FRK	1.37189181
17	BRSK1	1.18068571
18	CSNK1G3	1.02613280
19	TNIK	1.00949792
20	ZAK	0.99379380
21	PINK1	0.98355791
22	MAP2K6	0.93955368
23	NME2	0.93371454
24	WNK1	0.91911119
25	TRPM7	0.89618887
26	CSNK1A1L	0.89184163
27	EPHB2	0.87569921
28	NME1	0.87181079
29	PDK2	0.84358434
30	CSNK1G2	0.84356426
31	PBK	0.82113782
32	GRK1	0.80168115
33	DAPK2	0.79929865
34	STK39	0.78212809
35	BUB1	0.77201613
36	MAP2K4	0.74505666
37	ADRBK2	0.71730819
38	PLK3	0.71305205
39	TAOK3	0.69645180
40	CSNK1G1	0.66226288
41	EPHA4	0.65078192
42	FGFR1	0.62747175
43	OXSR1	0.56806295
44	SRPK1	0.54135230
45	CCNB1	0.53090229
46	INSRR	0.52878584
47	FGR	0.51659900
48	PRKCG	0.51392763
49	ITK	0.49687485
50	DAPK1	0.48257010
51	CSNK1E	0.46102732
52	MAPKAPK5	0.45809448
53	PLK1	0.43587363
54	PRKG1	0.41601014
55	PNCK	0.40955915
56	MAP2K3	0.40796481
57	CSNK2A2	0.38992814
58	DAPK3	0.38776865
59	WNK3	0.38505624
60	TSSK6	0.37052370
61	ILK	0.34808724
62	NEK6	0.34788372
63	MAP3K4	0.34082449
64	MAP4K2	0.33909052
65	ATR	0.32461095
66	MAPK12	0.32213977
67	DYRK1B	0.30246137
68	PHKG2	0.29890539
69	PHKG1	0.29890539
70	BCKDK	0.26397627
71	ADRBK1	0.26386488
72	MAPK13	0.26322393
73	MYLK	0.25410434
74	CSNK1A1	0.24331411
75	CSNK2A1	0.23907071
76	PRKACB	0.22598986
77	CAMK2A	0.22231166
78	CDK8	0.21905884
79	BMPR1B	0.20765981
80	PRKACA	0.20608670
81	AKT3	0.19424775
82	CSNK1D	0.19344842
83	IGF1R	0.19133617
84	TTK	0.18536358
85	PRKCE	0.18066246
86	SCYL2	0.17670468
87	GRK7	0.17430799
88	CDC7	0.17017192
89	PIK3CG	0.15869091
90	MAP2K7	0.15264082
91	MAPK15	0.15065619
92	MAPKAPK3	0.14899911
93	DYRK1A	0.14803684
94	TEC	0.14014256
95	EIF2AK1	0.13357566
96	OBSCN	0.13340630
97	TXK	0.12852254
98	CDK3	0.12184350
99	CAMK1	0.11775322
100	CAMK2G	0.10680052

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.52769375
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.80105207
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.57688170
4	Ribosome_Homo sapiens_hsa03010	3.53823191
5	Parkinsons disease_Homo sapiens_hsa05012	3.25039029
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.36980862
7	Alzheimers disease_Homo sapiens_hsa05010	2.29000754
8	Protein export_Homo sapiens_hsa03060	2.21449728
9	Mismatch repair_Homo sapiens_hsa03430	2.19051438
10	Proteasome_Homo sapiens_hsa03050	2.14339841
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.13763465
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.11385899
13	Huntingtons disease_Homo sapiens_hsa05016	2.05441166
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99266135
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84870256
16	Sulfur relay system_Homo sapiens_hsa04122	1.79773158
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.65575246
18	Propanoate metabolism_Homo sapiens_hsa00640	1.64772644
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64310956
20	Homologous recombination_Homo sapiens_hsa03440	1.60759024
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48734227
22	Fatty acid degradation_Homo sapiens_hsa00071	1.48094391
23	RNA polymerase_Homo sapiens_hsa03020	1.37326030
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37099362
25	RNA degradation_Homo sapiens_hsa03018	1.32587901
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.32476860
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30488177
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28996348
29	Sulfur metabolism_Homo sapiens_hsa00920	1.27943654
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.27578305
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.26801057
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.26115550
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.25596295
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.23431260
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23158961
36	Purine metabolism_Homo sapiens_hsa00230	1.10367157
37	Regulation of autophagy_Homo sapiens_hsa04140	1.07051447
38	Folate biosynthesis_Homo sapiens_hsa00790	1.05910333
39	Basal transcription factors_Homo sapiens_hsa03022	0.99373879
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95409100
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86565199
42	Peroxisome_Homo sapiens_hsa04146	0.85613490
43	Allograft rejection_Homo sapiens_hsa05330	0.84045629
44	Graft-versus-host disease_Homo sapiens_hsa05332	0.83468697
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80881070
46	Caffeine metabolism_Homo sapiens_hsa00232	0.77341506
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.77275264
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77236136
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77154666
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76678465
51	Phototransduction_Homo sapiens_hsa04744	0.74908138
52	DNA replication_Homo sapiens_hsa03030	0.73280280
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.72530097
54	Metabolic pathways_Homo sapiens_hsa01100	0.71950110
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71392490
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.71144591
57	Lysine degradation_Homo sapiens_hsa00310	0.69127515
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68168923
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67834403
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67187124
61	Base excision repair_Homo sapiens_hsa03410	0.64770441
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.63823818
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.63419734
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62505032
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58736165
66	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.58372282
67	Carbon metabolism_Homo sapiens_hsa01200	0.57211687
68	Olfactory transduction_Homo sapiens_hsa04740	0.54791059
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54034552
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53804601
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53611382
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.50579666
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50578827
74	Glutathione metabolism_Homo sapiens_hsa00480	0.50394611
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49520594
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47885766
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.46532150
78	Serotonergic synapse_Homo sapiens_hsa04726	0.46215709
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45868469
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45374664
81	Taste transduction_Homo sapiens_hsa04742	0.45023054
82	RNA transport_Homo sapiens_hsa03013	0.43971713
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43883068
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43474767
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40290919
86	Nicotine addiction_Homo sapiens_hsa05033	0.38661461
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36671788
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.36492691
89	Vibrio cholerae infection_Homo sapiens_hsa05110	0.35012329
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34836901
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33186684
92	Insulin secretion_Homo sapiens_hsa04911	0.32406803
93	Spliceosome_Homo sapiens_hsa03040	0.32121439
94	Galactose metabolism_Homo sapiens_hsa00052	0.31449970
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31319391
96	Retinol metabolism_Homo sapiens_hsa00830	0.30809553
97	One carbon pool by folate_Homo sapiens_hsa00670	0.30522195
98	Oocyte meiosis_Homo sapiens_hsa04114	0.30078106
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29620622
100	Morphine addiction_Homo sapiens_hsa05032	0.28146107

RPL23AP88

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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